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values | premise stringlengths 111 17k | NCT_title stringlengths 18 299 | NCT_id stringlengths 11 11 | label stringclasses 2
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1,373 | 8 | A 7-month-old boy is brought to emergency by his parents due to irritability and inability to defecate for the past 3 days. The patient has had constipation and discomfort with bowel movements since birth. His symptoms worsened after eating semi-solid foods. Vital signs are normal. Abdominal examination shows diste... | My baby boy just turned 7 months old but my wife and I cannot get a hold of him! He has not been able to poop for 3 days! My poor little thing has been having constipation and bowel problems since birth. But since he ate some semi-solid food it has just been worse! The doctor said his vitals are normal but his belly is... | Inclusion Criteria:
- Children between 2 and 16 years and referral to our out patient clinic with either
constipation or fecal incontinence.
- Patients must fulfill the Rome III criteria of constipation, which mean they must have
at least 2 of the following characterist... | Outpatient Treatment of Constipation in Children | NCT01582659 | Contradiction |
3,982 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- ambulatory, unilateral knee OA of at leas 3 months confirmed by radiography, pain
requiring NSAIDS for at least 2 months
Exclusion Criteria:
- no trauma to target knee within last 5 years, prior viscosupplementation therapy,
allergy to avi... | The Effectiveness of Hylan GF-20 on Joint Reaction Forces and Kinematic Patterns During Gait in Patients With Knee Osteoarthritis | NCT00147186 | Entailment |
979 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- Aged 18 - 90
- Definite diagnosis of IPJ osteoarthritis (American College of Rheumatology criteria
for OA)
- A previous radiograph of the hands with changes consistent with OA
- Either, Intervention group: At least 2 'affected' IPJs (sym... | Splinting to Treat Hand Osteoarthritis | NCT01249391 | Entailment |
4,207 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
- Age 18-45 years, inclusive, of both genders
- Negative pregnancy test for females who are not s/p hysterectomy with oophorectomy
- No history of episodic wheezing, chest tightness, or shortness of breath consistent
with asthma, or physician-diagnose... | Woodsmoke Particulate + Prednisone | NCT03861390 | Contradiction |
2,879 | 21 | A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year. Over the last few months, he has also noticed weakness in the right upper extremity. BP is 120/75, PR is 80 and temperature is 37 C. Reflex... | I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rat... | Inclusion Criteria:
- diagnosis of amyotrophic lateral sclerosis according to revised El Escorial criteria
- minimum of 18 years
- minimum of 6 months of residency in Rhinelnad-Palatinate
Exclusion Criteria:
- patients below 18 years
- ALS patients ou... | Amyotrophic Lateral Sclerosis Registry Rhineland-Palatinate | NCT01955369 | Entailment |
2,651 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
- >= 18 years of age
- undergoing one of 9 elective outpatient operations: partial mastectomy, partial
mastectomy and sentinel node biopsy, melanoma wide excision and sentinel node
excision, thyroidectomy, parathyroidectomy, open inguinal hernia repa... | A Prospective Study of Post-operative Opioid Use in General Surgery Patients | NCT02782884 | Entailment |
3,657 | 29 | A 57-year-old man comes to the emergency department due to constipation. His last bowel movement was 2 days ago. He complains of spending about 30 minutes once attempting to defecate. He also has lower back pain. There is no history of trauma. The pain is not relieved with over-the-counter pain medications. His vita... | I'm a 57 year-old-man, and I had to go to the ER because I couldn't go defecate. My last trip to the toilet was 2 days ago, and I tried too many times, during 30 min, to get my poop to get out. I also have terrible lower back pain. The doctor did not notice any trauma. I tried to get the pain away using over-the-counte... | Inclusion Criteria
Candidates for this study must meet ALL of the following criteria:
1. Age ≥18 years
2. Leg/buttock pain with or without back pain
3. Failed nonoperative medical management
4. A minimum leg pain score of 4.0 cm on the Visual Analogue Scale (VAS)
... | The iO-Flex® Study: Evaluation of the Baxano iO-Flex® System for Decompressive Lumbar Surgery | NCT01067014 | Contradiction |
5,260 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- Are at least 18 years of age
- Have sustained a painful osteoporotic vertebral compression fracture (VCF) for at
least 4 weeks but no longer than 1 year or have radiographic evidence of at least 5%
worsening vertebral collapse as compared to previo... | A Safety and Efficacy Study for Treatment of Painful Vertebral Compression Fractures Caused by Osteoporosis | NCT00290862 | Entailment |
5,939 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
- all patients with primary hiatus hernia type II-IV who are deemed suitable for surgery
Exclusion Criteria:
- inability to understand the nature of the purpose of the study and/or to give informed
consent.
- American Society of Anesthesiolog... | The Value of Lateral Release in Reconstruction of the Diaphragmatic Hiatus Hernia | NCT04179578 | Contradiction |
1,827 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | - INCLUSION CRITERIA:
- Patients with Cadherin-1 (CDH1) germline mutation known to be pathogenic or likely
pathogenic, which may also be classified as "significant" or "likely significant"
(patients with variants of "uncertain significance " are excluded)
or
-Pat... | Confocal Endoscopic Microscopy for Detection of Early Stage Gastric Cancer in Subjects With Hereditary Diffuse Gastric Cancer Syndrome | NCT03648879 | Entailment |
5,218 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- Postmenopausal Female patients up to 89 years, inclusive;
- BMI ≤ 35 kg/m2, inclusive;
- In good health, determined by medical history and physical examination, as well as
normal 12-lead ECG and vital signs;
- Females will be non-pregnan... | Study to Evaluate Effect of Intranasal Teriparatide on Bone Mineral Density in Postmenopausal Women With Low BMD | NCT00624481 | Entailment |
4,590 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
- Has, in the opinion of the investigator, suitable general and uterine conditions for
inserting the LCS.
- Normal cervical smear (normal cervical smear within the last six months prior to visit
1 presented in writing can be accepted. The cervical sm... | GA Levonorgestrel Intrauterine Contraceptive System (LCS) Phase III Study China | NCT00884260 | Contradiction |
4,173 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
- Participants will have:
1. a diagnosis of COPD which is clinically stable (including medications) for at
least one month;
2. spirometry results showing at least mild obstructive disease defined as post
bronchodilator f... | Dyspnea Self-Management: Internet or Face-to-Face | NCT00461162 | Contradiction |
836 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Patients (men and nonpregnant women) with systemic hypertension and patients with
hypercholesterolema will be included for this study.
Patient with aspirin allergies and those with a platelet count less than 50,000 will be
excluded.
Volunteers cannot be in any kind of medication while ... | The Role of Cyclooxygenase Activity in the Endothelial Function of Hypertensive and Hypercholesterolemic Patients | NCT00001742 | Entailment |
4,650 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
- females complaining of pelvic congestion: dysmenorrhea, dyspareunia, chronic pelvic
pain, menorrhagia, metrorrhagia
Exclusion Criteria:
- refusal of the patient to get enrolled in the study
Female
Accepts Healthy Volunteers
Subject must be at least 38 ... | Histopathological Diagnosis of Adenomyosis | NCT02340533 | Entailment |
4,123 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
- All male volunteers aged 18 to 45 years belonging to a couple reporting an involuntary
infertility greater than 12 months
- Conventional spermatic parameters compatible with spontaneous pregnancy
- Sperm Count> 5M / ml and
- Pr... | Evaluation of Personalised Support Program Effectiveness in Sperm Quality Improvement | NCT03475199 | Contradiction |
6,685 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- Subjects living at urban and rural parishes from Cuenca district.
- Subjects referred from professionals of public and private health services, who have
filled the initial hemorrhage survey.
- Must be referred women who sign the informed consent for... | Study on Von Willebrand Disease and Hemophilia in Cuenca, Ecuador | NCT01589848 | Contradiction |
59 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion Criteria:
- Males who meet the criteria of obese, hypogonadotropic hypogonadism defined as:
- Patients with a Body Mass Index (BMI) ≥ 30 kg/m2
- Patients with a morning serum total testosterone level < 300 ng/dL on at least
two separate occasions... | Safety and Efficacy of BGS649 in Obese, Hypogonadotropic Hypogonadal Men | NCT01200862 | Contradiction |
1,916 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
- age >= 18 yrs
- undergoing upper endoscopy procedure under general anesthesia without emergency
- informed written consent
Exclusion Criteria:
- emergency
- might impair gastrointestinal motility (intestinal obstruction, stenosis... | Safety and Efficacy of Carbohydrate Drink Ingested Two Hours Before Upper Endoscopy Under General Anaesthesia | NCT01471600 | Entailment |
2,260 | 15 | An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity m... | I brought my 8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weak... | Inclusion Criteria:
- No signs and symptoms of pulmonary diseases, normal ventilatory muscle strength and
agreement to participate and sign the informed consent form.
Exclusion Criteria:
- Presenting neuromuscular diseases, claustrophobia, ruptured eardrum, history of
... | Ventilatory Muscle Training by Breath-Stacking in Healthy Youngsters | NCT03258944 | Contradiction |
5,294 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- Ambulatory women greater or equal to 55 years, at least 2 years postmenopausal.
- Lumbar spine or total hip or femoral neck bone mineral density measurement must be at
least 2.5 standard deviations (SD) below the average bone mass for young women
(... | 2-Year Therapy With Teriparatide vs 1-yr Therapy Followed by 1-Year of Raloxifene or Calcium/Vit D in Severe Postmenopausal Osteoporosis | NCT00191425 | Entailment |
4,101 | 31 | A 25-year-old woman comes to the clinic with her roommate. The roommate says that the patient has twice fallen asleep while they were talking. The patient has regularly fallen asleep in the afternoon while reading or watching television but typically feels refreshed after a brief nap. She also reveals that she somet... | I brought my roommate to the clinic because she kept falling asleep when we were having a conversation. We're both 25 and usually healthy girls. She usually takes a nap in the afternoon while reading or watching TV, but usually, she is quite energetic afterward. She told me that she sometimes hears a voice before falli... | Inclusion Criteria:
- Signed informed consent
- Diagnosed with narcolepsy (diagnose code G47.4)
- 16 - 60 years of age
- MSLT has shown hypersomnia (sleeping latency < 8 min) & 1 episode REM
- HLA-type associated with increased occurrence of narcolepsy
... | Narcolepsy - New Potential Treatment | NCT02077036 | Entailment |
2,856 | 21 | A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year. Over the last few months, he has also noticed weakness in the right upper extremity. BP is 120/75, PR is 80 and temperature is 37 C. Reflex... | I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rat... | Inclusion Criteria:
1. Clinically definite or probable Amyotrophic Lateral Sclerosis (ALS) or
laboratory-supported probable ALS as defined in the revised El Escorial/Airlie House
diagnostic criteria
2. The site of onset of ALS symptoms is a limb and experiencing symptoms ... | Safety of Engensis in Participants With Amyotrophic Lateral Sclerosis | NCT04632225 | Entailment |
6,409 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- Patients with clinically diagnosed influenza, body temperature ≥ 38 ºС or other acute
respiratory viral infection, body temperature ≥ 37 ºС, with no less than 2 symptoms of
catarrhal and intoxication each:
- Intoxication symptoms: Dizziness, h... | Efficacy and Safety Study of Ingavirin® 90 mg Once Daily to Treat Influenza and Other Acute Viral Infections in Adults | NCT03154515 | Entailment |
5,313 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- Men and postmenopausal women who have a previous vertebral osteoporotic fracture that
was sustained at least 6 weeks prior to joining the study.
- Patients who are free of severe or chronically disabling conditions other than
osteoporosis.
... | Back Pain in Patients With Severe Osteoporosis | NCT00761332 | Entailment |
3,228 | 23 | A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn. The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness. She also reports occasional joint pain. Medical history... | I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to t... | Inclusion Criteria:
- Suspicion of Sjogren's syndrome based on 2016 American College of Rheumatology (ACR)
criteria;
- Age ≥ 18 years
- Being affiliated to health insurance
- Willing to participate
Exclusion Criteria:
- Pregnant or breast... | Involvement of Immune Cells Derived From the Intestine in Sjogren's Syndrome | NCT03841318 | Entailment |
863 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- Self-reported hip or knee osteoarthritis
Exclusion Criteria:
- Persons who do not understand the Norwegian language
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
| Improve Osteoarthritis Care | NCT04670549 | Entailment |
500 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- The inclusion criteria for RIF group were: unexplained repeated implantation failure
(RIF) is defined as the absence of a gestational sac on ultrasound at 5 or more weeks
after embryo transfer (ET) after 3 embryo transfers with high quality embryos or after
... | Transcriptomic Profile of Endometrium in Different Histological Dating of Natural Cycle | NCT03222830 | Contradiction |
2,322 | 15 | An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity m... | I brought my 8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weak... | Inclusion Criteria:
- Known null mutation of the Dystrophin gene
- Male age of 5 years or older
- If taking corticosteroids, must have dose unchanged for the past 3 months
- Serum creatine kinase elevation greater than 10x normal value (established by
Childre... | Safety Study of Mini-dystrophin Gene to Treat Duchenne Muscular Dystrophy | NCT00428935 | Entailment |
2,282 | 15 | An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity m... | I brought my 8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weak... | Inclusion Criteria:
1. Patients 10 - 18 years of age at Baseline.
2. Signed and dated informed consent.
3. Documented diagnosis of DMD or severe dystrophinopathy and clinical features
consistent of typical DMD at diagnosis (i.e. documented delayed motor skills and
... | Phase III Study of Idebenone in Duchenne Muscular Dystrophy (DMD) | NCT01027884 | Contradiction |
214 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion Criteria:
- Male, 18 - 65 years of age;
- Documented testosterone deficiency;
- BMI 18 to 33.
Exclusion Criteria:
- Evidence of prostate cancer and benign prostate hyperplasia;
- Taking medications that interfere testosterone metabolism;
... | Pharmacokinetics, Metabolism, Efficacy, and Safety Study of Two Testosterone Matrix Transdermal Systems | NCT01323140 | Entailment |
6,352 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- Positive COVID-19 RT-PCR to the subject or his/her household.
- Over 18 years old
- Ability to sign an informed consent
Exclusion Criteria:
- Inability to sign an informed consent
- Pregnancy
No condition on gender to be admitted... | Evaluating the Immune Response for COVID-19 | NCT04348422 | Entailment |
2,599 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
- recurrent inguinal hernia
- willing to participate
Exclusion Criteria:
- unwilling to participate
- bilateral hernia
- preference towards either treatment arm
No condition on gender to be admitted to the trial.
No healthy subject... | Recurrent Inguinal Hernia Treatment - Lichtenstein Versus Laparoscopic Totally Extraperitoneal Preperitoneal Hernioplasty | NCT00642200 | Contradiction |
363 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Patient with thickened endometrium
- Abnormal uterine bleeding
Exclusion Criteria:
- Pregnant
- Active pelvic infection
- Pelvic inflammatory disease
- Blood clotting disorders
- Sexually transmitted disea... | Evaluation of the Goldstein SonoBiopsy™ Catheter for Diagnosing Endometrial Pathology | NCT01969396 | Contradiction |
5,532 | 41 | A 61-year-old man comes to the emergency department complaining of an acute vision disturbance. He had an episode of vision disturbance in the right eye that occurred suddenly and resolved spontaneously in 15 minutes. He also has right jaw pain while chewing. He also complains of fatigue and hip muscle aches over the ... | I’m a 61-year-old man and I came to the ER because I had a sudden episode where I couldn’t see out of my right eye. It only lasted about 15 minutes and went away on its own but it really scared me. I’ve also been having pain in my right jaw when I chew. For the past few months I’ve felt really tired and noticed my hips... | Inclusion Criteria:
- Age ≥ 50 years
- ACR criteria for Giant cell arteritis (HUNDER 1990)
- Positive Temporal artery biopsy
- Plus standard inclusion criteria for Humira protocols
Exclusion Criteria:
- Prednisone treatment for a different disease at ... | HECTHOR: Humira to Spare Steroids in Giant Cell Arteritis | NCT00305539 | Entailment |
5,439 | 40 | A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction. Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration. The patient has heavy menstrual cycles each month. She has no other medical problems and takes no medications... | I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical c... | Inclusion Criteria:
- at least one prescription medicine for a chronic condition for at least six months
- deemed to be suitable for MUR by a pharmacist, certified to provide the MUR service;
- ability to communicate in Slovenian; The inclusion of patients was performed in
... | Evaluation of Medicines Use Review in Slovenia | NCT04417400 | Entailment |
5,104 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- Age 65 - 85 years • BMI 30 - 40 kg/m2 • Stable body weight (±2 kg) during the past 6
months • Sedentary (regular exercise <1 h/wk. or <2 x/wk. for the last 6 months) •
Willing to provide informed consent
Exclusion Criteria:
- Failure to pr... | Lifestyle Intervention to Improve Bone Quality | NCT03329963 | Contradiction |
391 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | - Inclusion criteria
- Patients whose written IC approved by the EC has been obtained, after having been
duly informed of the nature of the study and voluntarily accepted to participate
after being fully aware of the potential risks, benefits and any discomfort
... | RCT to Assess the Impact of Microbiome Status in Infertile IVF Patients at Their First IVF/ICSI Cycle | NCT04686357 | Contradiction |
4,892 | 37 | A 47-year-old man comes to the office due to weight gain and fatigue. He is not able to lift heavy objects or climb stairs. Family history is positive for DM type 2 and HTN in his father. Blood pressure is 165/90 mm Hg and pulse is 85/min. On physical examination, there is symmetric proximal muscle weakness of the u... | I'm a 47-year-old man. I went to the clinic because I had been gaining weight and had increased fatigue over the past few weeks. I was not able to lift heavy objects or even climb the stairs. My dad was diagnosed with type 2 diabetes and high blood pressure. During the exam, they took my blood pressure, which was 165/9... | Inclusion Criteria:
- Clinical diagnosed Cushing's disease
Exclusion Criteria:
- Already received treatment in other hospital
- Ectopic Cushing's syndrome
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
| The Factors Associated With the Recurrence in Patients With Cushing Disease | NCT02233335 | Entailment |
4,974 | 38 | A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago. It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amoun... | I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaki... | No eligibility criteria
Male
No healthy subjects accepted to join the trial.
Subject must be at most 100 Years | Antecedents of Bronchopulmonary Dysplasia | NCT00005293 | Entailment |
3,522 | 26 | A 33-year-old woman comes to clinic complaining of progressive fatigue, decreased appetite, and 11-lb weight loss in the past 2 months. She uses levothyroxine because of the previously diagnosed Hashimoto disease. She has no other medical conditions and does not use tobacco, alcohol, or illicit drugs. Physical examin... | I went to the clinic because I was really suffering from fatigue and decreased appetite and I also lost 11 pounds over the past two months. I'm just 33 years old so that's not normal, especially for a woman. I take levothyroxine because I have been diagnosed with Hashimoto disease. I don't have any other medical condit... | Inclusion Criteria:
- Hashimoto thyroiditis euthyreot thyroid function with levothyroxin therapy written
informed consent
Exclusion Criteria:
- • hypothyroidism of other origin
- pregnancy and lactation
- oral contraception
... | Isolated ACTH Deficiency in Patients With Hashimoto Thyroiditis | NCT00552487 | Contradiction |
6,541 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- Healthy male and female subjects age 18 to 45 years of age included, and in good
health as determined by past medical history, physical examination, vital signs,
electrocardiogram, and laboratory tests at screening.
- Vital signs must be within the... | Study to Explore the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Oral AHT956 in Healthy Subjects | NCT00410228 | Contradiction |
2,125 | 13 | A 24-year-old man comes to the office complaining of infertility. He and his wife have been trying to conceive for the last 18 months. Medical records of his wife showed no abnormalities. The patient doesn't smoke and takes no medications. Height is 185 cm and weight is 77 kg. Heart and lung sounds are normal. Th... | I'm only a 24 year old man but I’m already struggling with infertility. I went to a clinic with my wife the other day because we've been trying to have a baby for at least 18 months. The medical records of my wife are totally normal. For me I don't smoke or take any medication. I'm 185 cm and 77 kg. Everything was norm... | - INCLUSION CRITERIA:
1. Patients previously identified through outside research or diagnostic labs as
having sex-chromosome variants causing deletion/duplication of sex-linked genes
or entire sex chromosomes, male and female.
2. In the event that a p... | The Clinical Study of Sex Chromosome Variants | NCT01661010 | Entailment |
1,675 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | Inclusion Criteria:
- American Indian ethnicity
- Membership in the White Mountain Apache community. (Although the investigators
anticipate the vast majority of participants will be White Mountain Apache tribal
members, study participation is open to all American Indian... | Evaluation of Respecting the Circle of Life on Pregnancy Prevention Outcomes Among American Indian Adolescents | NCT02904629 | Entailment |
292 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Singleton Pregnancy.
- Age20-35years.
- Gestational age between6 to 8weeks.
- Threatened miscarriage is diagnosed by vaginal bleeding, closed cervix and positive
fetal life.
- Patients who are sure of their dates (three regul... | Biochemical Versus Ultrasound Findings as Predictors of Fetal Loss in Cases of First Trimester Threatened Miscarriage | NCT03797508 | Contradiction |
3,061 | 22 | A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination. The boy is going to a school for students with learning disabilities. The patient was adopted, and his immunizations are up to date. Review of the patient's medical records is notable for c... | My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it co... | Inclusion Criteria:
- Patients with Fragile X Syndrome, who are at least moderately ill based on a Clinical
Global Impression Severity score of at least 4 and have qualifying scores on the ABC-C
and IQ test at Visit 1
Exclusion Criteria:
- Advanced, severe or u... | Safety and Efficacy of AFQ056 in Adolescent Patients With Fragile X Syndrome | NCT01357239 | Entailment |
5,511 | 41 | A 61-year-old man comes to the emergency department complaining of an acute vision disturbance. He had an episode of vision disturbance in the right eye that occurred suddenly and resolved spontaneously in 15 minutes. He also has right jaw pain while chewing. He also complains of fatigue and hip muscle aches over the ... | I’m a 61-year-old man and I came to the ER because I had a sudden episode where I couldn’t see out of my right eye. It only lasted about 15 minutes and went away on its own but it really scared me. I’ve also been having pain in my right jaw when I chew. For the past few months I’ve felt really tired and noticed my hips... | Inclusion Criteria:
Cases:
- 1) age ≥50 years, 2) CRP>15mg/l or ESR>40mm/h, 3) either a) cranial symptoms, b)
new-onset extremity claudication or c) weight loss >5 kilograms or fever>38oC for >3
weeks and a clinical diagnosis of giant cell arteritis judged by expert
... | Diagnostic Accuracy of FDG PET/CT of Cranial Arteries in GCA | NCT03409913 | Entailment |
2,281 | 15 | An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity m... | I brought my 8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weak... | Inclusion Criteria:
- All patients with the diagnosis of muscular dystrophy.
Exclusion Criteria:
- Patients that do not carry the diagnosis of muscular dystrophy.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least... | The Cardiovascular Genetic and Therapeutic Implications of Muscular Dystrophy | NCT00518817 | Contradiction |
3,680 | 29 | A 57-year-old man comes to the emergency department due to constipation. His last bowel movement was 2 days ago. He complains of spending about 30 minutes once attempting to defecate. He also has lower back pain. There is no history of trauma. The pain is not relieved with over-the-counter pain medications. His vita... | I'm a 57 year-old-man, and I had to go to the ER because I couldn't go defecate. My last trip to the toilet was 2 days ago, and I tried too many times, during 30 min, to get my poop to get out. I also have terrible lower back pain. The doctor did not notice any trauma. I tried to get the pain away using over-the-counte... | Inclusion Criteria:
- Patients who have attended Darlington Memorial Hospital between 01-08-2016 and
31-07-2017
- Aged 16 or over
Exclusion Criteria:
- Below the age of 16
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject mus... | Characteristics of Back Pain Attendances at ED | NCT03762174 | Entailment |
2,008 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
- Stomach pain, swelling or dispeptic complaints.
- Men and women between the ages of 18-60.
- Patients with VAS> 5.
Exclusion Criteria:
- Pregnancy and lactation.
- Sucralfate, alginate, hydrotalcite allergy.
- Emergen... | A Comparison of Effectiveness of Oral Sucrolfate, Alginate and Hydrotalcide in Dispeptic Pain Treatment | NCT03635372 | Entailment |
6,645 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- Females of reproductive age who experience monthly menstrual bleedings
- Female Hemophilia A or B carrier (heterozygote, lyonized or Turner's Syndrome)
- FVIII or FIX activity ≤60% at time of the study
- Baseline Pictorial Bleeding Assessment Chart >... | Extended Half Life Factor (EHF) Products For Heavy Menstrual Bleeding in Hemophilia Carriers | NCT03272568 | Contradiction |
3,390 | 25 | A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear. Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus. Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy s... | I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. ... | Inclusion Criteria:
- Healthy subjects at the time of enrollment.
- Each subject will give informed consent to participate in this study and agrees to the
treatment protocol.
- Each subject will be interviewed regarding hearing and health to reveal any history of
... | Otoprotection With SPI-1005 for Prevention of Temporary Auditory Threshold Shift | NCT01444846 | Contradiction |
184 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion Criteria:
1. Male research participant, aged 18 years or older, with BMI between 18.50 and 32.00
kg/m2;
2. To present symptomatic or asymptomatic hypogonadism and serum total morning
testosterone levels ≤ 300 ng / dL;
3. Laboratory evaluation of prost... | Efficacy and Safety of Testosterone Nasal Gel for Treating Hypogonadism in Men. | NCT03281187 | Entailment |
5,774 | 43 | A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers. The rashes are mildly itchy. The patient has no other medical conditions and takes no medications. Vital signs are normal. On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and a... | I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been ... | Inclusion Criteria:
- Ability to understand and consent to participate in this clinical research, expressed
by signing the Informed Consent Form (ICF);
- Participants with moderate or severe clinical diagnosis of superficial mycoses caused
by Candida ssp or following fu... | Effectiveness Study of Ketoconazole and Betamethasone to Treat Fungal Infection and Dermatophytosis | NCT02582177 | Contradiction |
1,962 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion criteria:
-) subjects with small gastric subepithelial tumors who underwent endoscopic unroofing
Exclusion criteria:
-) none
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at ... | Endoscopic Unroofing for Small Gastric SETs | NCT02587923 | Entailment |
2,507 | 18 | A 2-year-old boy is brought to the office by his parents due to a rash that started 1 week ago. A similar red, itchy rash on the cheeks, trunk, and arms has occurred intermittently since infancy. The patient has had a few upper respiratory infections but no major illnesses. Vaccinations are up to date, and he takes ... | I just brought my two-year-old son to the doctor's office because he had a rash for like one week. His rash was on the cheeks, the trunk, and his arms. He already had this before, and it keeps coming back from time to time to time. In the past, he had some respiratory infections but he has never been this sick. His vac... | Inclusion Criteria:
1. Between 6 and 65 years old, female or male.
2. Atopic dermatitis fulfilling the diagnostic criteria of Williams et al.
3. Atopic dermatitis involving <40% of BSA. (Base on the BSA result of Screening)
4. An Investigator's Global Assessment (IGA) score o... | Indigo Naturalis in Treating Atopic Dermatitis Topically | NCT02669888 | Contradiction |
4,056 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | 1. Inclusion criteria:
1. Age between 18 to 50
2. Ant. Knee pain
3. Resistant cases to medical and physiotherapy after 6 months.
4. Intact tibiofemoral joints or early O.A , and intact meniscus, cruciate
ligaments, and Collateral ligament... | Arthroscopic Treatment of Resistant Cases of Patellofemoral Pain | NCT03615976 | Entailment |
2,274 | 15 | An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity m... | I brought my 8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weak... | Inclusion Criteria:
1. Male patients with a 35% ≤ FVC ≤ 80% of predicted value at Screening and at Baseline
and who, in the opinion of the investigator are in the respiratory function decline
phase.
2. Minimum 10 years old at Screening.
3. Signed and dated Info... | A Phase III Double-blind Study With Idebenone in Patients With Duchenne Muscular Dystrophy (DMD) Taking Glucocorticoid Steroids | NCT02814019 | Contradiction |
3,594 | 28 | A 23-year-old woman comes to the emergency department with a history of nosebleeds lasting for 1 hour. She has a history of heavy menses as well as occasional gum bleeding following dental procedures. Her mother also has a history of menorrhagia. Laboratory tests reveal increased bleeding time and slightly increased pa... | I had to rush to the ER because of a non-stop nosebleed that had been on for 1 hour. As a 23-year-old, I always had heavy periods, and sometimes, my gums would bleed after going to the dentist or brushing my teeth. I thought that it was not very alarming since my mom also had heavy periods. I did some lab tests that sh... | Inclusion Criteria:
1. 18-45 years of age at the time of screening
Exclusion Criteria:
2. Participants unable to tolerate the scanning procedures or would be unfit for scanning
purposes (e.g. metal implants, claustrophobic, unable to lie still for the duration of
... | Deciphering the Role of Oxytocin in Motivation: an fMRI Study. Part II | NCT02652195 | Contradiction |
2,942 | 21 | A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year. Over the last few months, he has also noticed weakness in the right upper extremity. BP is 120/75, PR is 80 and temperature is 37 C. Reflex... | I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rat... | To be eligible for enrollment in this study, subjects must meet the following eligibility
criteria within fourteen days prior to randomization:
Inclusion criteria:
- A clinical diagnosis of laboratory-supported probable, probable or definite ALS,
according to modified EL Escori... | Minocycline to Treat Amyotrophic Lateral Sclerosis | NCT00047723 | Entailment |
3,298 | 24 | A 4-year-old boy comes to the office for the follow up of his confirmed oculocutaneous albinism. The patient was born at 38 weeks gestation with no complications. Vital signs are normal. Weight and height are at the 50th percentile. On examination, iris transillumination is present, and there are no apparent foveae... | I brought my four-year-old son to his follow-up consultation for his albinism. All his hair is white, even lashes and eyebrows. My baby was born at 38 weeks pregnant with no complications whatsoever. During the consultations his vitals were normal and now his weight and height are at the 50th percentile. The doctor did... | - INCLUSION CRITERIA:
To be eligible, the following inclusion criteria must be met, when applicable.
1. Participant must be 18 years of age or older.
2. Participant must understand and sign the protocol s informed consent document.
3. Participant must have normal renal functio... | Nitisinone for Type 1B Oculocutaneous Albinism | NCT01838655 | Contradiction |
4,072 | 31 | A 25-year-old woman comes to the clinic with her roommate. The roommate says that the patient has twice fallen asleep while they were talking. The patient has regularly fallen asleep in the afternoon while reading or watching television but typically feels refreshed after a brief nap. She also reveals that she somet... | I brought my roommate to the clinic because she kept falling asleep when we were having a conversation. We're both 25 and usually healthy girls. She usually takes a nap in the afternoon while reading or watching TV, but usually, she is quite energetic afterward. She told me that she sometimes hears a voice before falli... | Inclusion Criteria:
- Veteran Enrolled in the Minneapolis/St. Cloud VAHCS.
- Diagnosis of PTSD via American Psychiatric Association PTSD diagnostic criteria in the
fifth edition of its Diagnostic and Statistical Manual of Mental Disorders (DSM-5).
- Equal to or older tha... | Traumatic Nightmares Treated by NightWare (To Arouse Not Awaken) | NCT03795987 | Contradiction |
3,773 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
1. Males or Females 40 years and older
2. According to the clinical diagnosis standard of the American College of Rheumatology
(ACR), someone, diagnosed as a single/both sides of osteoarthritis, who corresponds to
over 3 conditions of followings.
... | Clinical Trial of YYD302 for Treatment of Osteoarthritis of the Knee | NCT02965495 | Entailment |
5,380 | 40 | A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction. Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration. The patient has heavy menstrual cycles each month. She has no other medical problems and takes no medications... | I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical c... | Patients of either sex requiring removal of two impacted mandibular third molars (partial
bony or soft tissue impaction).
16 years of age of older.
Indicates willingness to undergo oral surgery with local anesthesia and intravenous
midazolam only.
Willing to return for the rem... | Local Flurbiprofen to Treat Pain Following Wisdom Tooth Extraction | NCT00001724 | Entailment |
6,162 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- healthy Caucasian origin
- age between 18 and 55 years
- accepting not to participate in another COVID-19 vaccine study until the end of the
study
- volunteers who do not plan to get a child in the next one year; the volunteer and the
... | Safety and Immunogenicity of Two Different Strengths of the Inactivated COVID-19 Vaccine ERUCOV-VAC | NCT04691947 | Contradiction |
3,711 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | - INCLUSION CRITERIA:
Subjects must be 21-45 years of age.
Subject must be in good health and able to perform cycle ergometry for the length of the
study.
Subjects must provide informed, written consent for participation in this study.
Female subjects of childbearing age mus... | Effect of Nitrite on Exercise Physiology and Metabolism | NCT00105222 | Contradiction |
6,380 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
1. The patient is attending for triage presenting with symptoms of an infection.
2. Subject has provided informed consent
3. Age ≥18 years
4. Fluent in Swedish (reading, writing, conversational)
5. Mental state is such that he or she is able to ... | Covid-19 Triage Using Camera-based AI | NCT04383457 | Entailment |
2,168 | 14 | A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain. The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medicat... | I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopuri... | Inclusion Criteria:
- Japanese HU patients (Outpatient)
- Patients who meet the following criteria concerning serum uric acid levels at the
screening [1) Gout: > 7.0 mg/dL, 2) HU with complications: ≥ 8.0 mg/dL, 3) HU without
complications: ≥ 9.0 mg/dL]
Exclusi... | Phase II Exploratory Clinical Study of KUX-1151 | NCT02190786 | Contradiction |
6,717 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- Subjects with severe hemophilia A (< 2% FVIII:C)
- Subjects with no history of FVIII inhibitor antibody formation
- Subjects with no measurable inhibitor activity
- Subjects with at least 200 EDs with FVIII concentrate in total, including 20 EDs in
... | Assessment of the Risk of Inhibitor Formation in Previously Treated Patients With Severe Hemophilia A | NCT00621673 | Contradiction |
879 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- • Subjects with hand OA having suffered from transient inflammatory attacks of the
interphalangeal finger joints characteristic for what has been termed 'inflammatory'
or 'erosive' hand OA.
- Subjects with hand OA showing inflammatory signs, e... | RANKL-blockade for the Treatment of Erosive Osteoarthritis (OA) of Interphalangeal Finger Joints | NCT02771860 | Entailment |
6,227 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- Healthy on the basis of physical examination, medical history, vital signs, and
12-lead electrocardiogram (ECG) performed at screening. If there are abnormalities,
they must be consistent with the underlying illness in the study population. This
d... | A Study of the Newly Formulated Tylenol Tablet (Acetaminophen) to the Tylenol 8 Hour (H) Extended Release (ER) Tablet (Acetaminophen) in Healthy Participants | NCT04230252 | Contradiction |
2,121 | 13 | A 24-year-old man comes to the office complaining of infertility. He and his wife have been trying to conceive for the last 18 months. Medical records of his wife showed no abnormalities. The patient doesn't smoke and takes no medications. Height is 185 cm and weight is 77 kg. Heart and lung sounds are normal. Th... | I'm only a 24 year old man but I’m already struggling with infertility. I went to a clinic with my wife the other day because we've been trying to have a baby for at least 18 months. The medical records of my wife are totally normal. For me I don't smoke or take any medication. I'm 185 cm and 77 kg. Everything was norm... | Inclusion Criteria:
- Couple whose man is from 18 to 60 years old
- Couple whose man presents an infertility indicating a care in VITRO fertilization with
or without intracytoplasmic sperm injection (IVF +/- ICSI)
- Couple whose spouse is from 18 to 38 years old
... | Impact of Folates in the Care of the Male Infertility | NCT01407432 | Entailment |
5,601 | 42 | A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively. On physical examination, the patient's height is in the 5th percentile of her age. Other findings include low-set ears, a high arched palate... | I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a we... | Inclusion Criteria:
- male or female children with ISS
- age greater than or equal to 8 years and less than or equal to 12 years and 3 months
for girls and greater than or equal to 9 years and less than or equal to 14 years and
3 months for boys
- bone age l... | Somatropin + Leuprorelin vs Somatropin Alone in Pubertal Children With Idiopathic Short Stature | NCT00355030 | Contradiction |
5,583 | 42 | A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively. On physical examination, the patient's height is in the 5th percentile of her age. Other findings include low-set ears, a high arched palate... | I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a we... | Inclusion Criteria:
- Adolescent girls 13-21 years old with bone age ≥ 14 years
- Overweight girls: Body Mass Index (BMI) greater than the 95th percentile for age
- Waist/Hip ratio ≥ 0.85
- Insulin Like Growth Factor -1 (IGF-1) below -0.5 standard deviations (SD) for pube... | Effect of Recombinant Human Growth Hormone (rhGH) on Abdominal Fat and Cardiovascular Risk in Obese Girls | NCT01169103 | Contradiction |
3,153 | 23 | A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn. The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness. She also reports occasional joint pain. Medical history... | I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to t... | Inclusion Criteria:
- Male or female, aged 18 to 80 years (inclusive), and capable of providing their
written informed consent.
- Male subjects must be either not sexually active, surgically sterilized, or agree to
use an appropriate "double-barrier" method during study... | A Safety and Efficacy Study of 552-02 in Subjects With Dry Mouth Associated With Sjogren's Syndrome | NCT00852839 | Contradiction |
6,441 | 47 | A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks... | I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun.... | Key Inclusion Criteria:
1. Male or female who is at least 18 years of age or older.
2. A clinical diagnosis of facial rosacea.
3. A Clinician Erythema Assessment (CEA) score of greater than or equal to 3 at Screening
and at Baseline/Day 1 (prior to the study drug applicatio... | Phase 3 Efficacy and Safety Study of CD07805/47 Topical Gel in Subjects With Facial Erythema Associated With Rosacea | NCT01355458 | Entailment |
4,048 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Key Inclusion Criteria (additional criteria may apply at screening):
1. A clinical diagnosis of osteoarthritis (OA) of the knee or hip based on the American
College of Rheumatology criteria with radiologic evidence of OA (K-L score ≥2 for the
index joint) at the screening visit.
... | Study to Determine the Safety and the Efficacy of Fasinumab Compared to Placebo and Nonsteroidal Anti-inflammatory Drugs (NSAIDs) for Treatment of Adults With Pain From Osteoarthritis of the Knee or Hip | NCT03304379 | Entailment |
5,524 | 41 | A 61-year-old man comes to the emergency department complaining of an acute vision disturbance. He had an episode of vision disturbance in the right eye that occurred suddenly and resolved spontaneously in 15 minutes. He also has right jaw pain while chewing. He also complains of fatigue and hip muscle aches over the ... | I’m a 61-year-old man and I came to the ER because I had a sudden episode where I couldn’t see out of my right eye. It only lasted about 15 minutes and went away on its own but it really scared me. I’ve also been having pain in my right jaw when I chew. For the past few months I’ve felt really tired and noticed my hips... | Inclusion Criteria:
Participants must:
1. Meet the revised GCA diagnosis criteria (modified from ref 1)
2. Have either newly-diagnosed or relapsing disease
3. Have active disease (modified from ref 1, to remove ESR/CRP requirements)
4. Have been empirically started o... | Use of Gallium-68 HA-DOTATATE PET/CT in Giant Cell Arteritis (GCA) | NCT03812302 | Entailment |
1,248 | 6 | A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea. The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease. He smokes 2 packs of cigarettes daily for the past 30 years. On examination, there are decreased breath sounds and percussive d... | I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my ... | DISEASE CHARACTERISTICS:
- Radiologic evidence of a unilateral malignant pleural effusion requiring sclerosis or
ongoing drainage because it is symptomatic (dyspnea and/or progressive fatigue)
- An asymptomatic patient is eligible if the patient underwent a prior
... | Standard Chest Tube Compared With a Small Catheter in Treating Malignant Pleural Effusion in Patients With Cancer | NCT00042770 | Entailment |
5,798 | 43 | A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers. The rashes are mildly itchy. The patient has no other medical conditions and takes no medications. Vital signs are normal. On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and a... | I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been ... | Inclusion Criteria:
- Patients with Oral ulcers due to Benin mucous membrane pemphioid, Pemphius vulgaris
and Steven Johnson's Syndrome with mucositis score 4 and pain score 10
Exclusion Criteria:
- patients with any systemic other systemic condition
No condition on gender ... | PRF in Management of Chronic Multiple Oral Ulcers | NCT03878771 | Contradiction |
2,061 | 12 | A 47-year-old man comes to the office for routine checkup. He is complaining of chronic cough and occasional but progressive dyspnea. Other medical conditions include hypertension and osteoarthritis. The patient smokes a pack of cigarettes daily and does not use alcohol or illicit drugs. He used to be a construction... | I'm a 47-year-old former construction worker. I'm a man and I smoke a pack of cigs a day but I don't drink or do drugs. I went to my routine checkup because I've been coughing so much lately. I also had shortness of breath and it got worse over time. I already suffer from hypertension and osteoarthritis. My doctor foun... | Inclusion Criteria:
- diagnosis of asbestosis
Exclusion Criteria:
- other diseases
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
| Oscillation Mechanics of the Respiratory System Asbestos Exposed: Early Diagnosis | NCT02280343 | Contradiction |
1,453 | 9 | A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough. Her other medical problems include hypertension, dyslipidemia, and osteoarthritis. She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary ... | I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pr... | Inclusion Criteria:
- age > 18
- complaint of dysphagia
Exclusion Criteria:
- pregnancy
- age <18
- on inhaled steroids within the last 30 days
- on systemic steroids in the last 30 days
- known diagnosis of Eosinophilic Esopha... | Routine Screening for Eosinophilic Esophagitis in Patients Presenting With Dysphagia | NCT01028235 | Entailment |
4,525 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
To enroll into the clinical trial, potential subjects must:
1. Be in good general overall health with no chronic medical conditions that result in
periodic exacerbations that require significant medical care.
2. Be women between 18 and 35 years inclusive a... | Study of the Safety and Efficacy of Ulipristal Acetate (UPA) Used Daily as a Contraceptive | NCT03296098 | Contradiction |
1,463 | 9 | A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough. Her other medical problems include hypertension, dyslipidemia, and osteoarthritis. She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary ... | I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pr... | Inclusion Criteria:
1. Dyslipidemia: Total cholesterol (TC) >200 mg/dL; LDL-C > 130 mg/dL ; TG > 200 mg/dL;
male HDL-C < 40 mg/dL, female HDL-C < 50 mg/dL, or under lipid lowering therapy
2. Atherosclerotic vascular disease:
1. Coronary atherosclerosis as evidenced by ... | Circulating Non-coding RNAs and Cardiovascular Outcomes in Patients With Dyslipidemia and Atherosclerosis | NCT03279770 | Entailment |
4,335 | 33 | A 20-year-old man comes to the clinic for his routine checkup. The patient wears glasses for myopia and takes no medications. Vital signs are normal. On physical examination, the patient is tall with long upper extremities and fingers. The face appears narrow with down-slanted palpebral fissures, flattened malar bon... | I'm a 20-year-old guy, working as a driver and I went to the clinic for my routine checkup. I have myopia, so I wear glasses and I don't take any other medications. My vitals were normal. I also did a physical exam, and I was told that I have long legs, arms, and fingers. They also told me that my face is quite narrow,... | Inclusion Criteria:
1. Male and female subjects in the range of 18 - 45 years of age.
2. Body weight within ± 15% of ideal weight as related to height and body frame according
to Life Insurance Corporation (LIC) Chart. (Appendix A)
3. Subjects with normal findings as determ... | Bioequivalence Study of Torrent Pharmaceutical Ltd.'s Zolpidem Tartrate Tablets Under Fasted Conditions | NCT00939536 | Contradiction |
1,578 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | Inclusion Criteria:
1. Male subjects between the ages of 40 and 55 years with a body weight between 60 and 90
kg and a body mass index calculated using Quetelet's Index - weight (kg)/height2 (m2)
between 18.5 - 30.0
2. Signed and dated a written informed consent form (ICF... | Human Mass Balance Study of Pyronaridine | NCT01383109 | Contradiction |
4,409 | 34 | A 17-year-old male comes to the office due to several months of right elbow pain. The pain is worse with activity and limits his workouts and activities. He has tried over-the-counter medications with limited relief. Medical history is notable for eczema, and current medications include a topical hydrocortisone oint... | I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that... | Inclusion Criteria:
1. Subject has signed the Institutional Review Board (IRB) approved Informed Consent Form
specific to this study prior to enrollment
2. Subject has a clinical diagnosis of lateral epicondylitis
3. Subject's symptoms can be reproduced with resisted supina... | Phase II Study of the Effects of rhPDGF-BB Injection on Lateral Epicondylitis | NCT01746420 | Contradiction |
4,460 | 34 | A 17-year-old male comes to the office due to several months of right elbow pain. The pain is worse with activity and limits his workouts and activities. He has tried over-the-counter medications with limited relief. Medical history is notable for eczema, and current medications include a topical hydrocortisone oint... | I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that... | Inclusion Criteria:
- written informed consent
- age 18-65
- employed
- chronic lateral epicondylitis (duration >3 months)
- pain in lateral epicondyle
- pain in resisted wrist extension in elbow extension (Cozen test)
- X-ray or Magnet... | Levobupivacaine Versus Liposomal Bupivacaine (Exparel®) for Treatment of Pain and Disability in Lateral Epicondylitis | NCT04382144 | Contradiction |
4,421 | 34 | A 17-year-old male comes to the office due to several months of right elbow pain. The pain is worse with activity and limits his workouts and activities. He has tried over-the-counter medications with limited relief. Medical history is notable for eczema, and current medications include a topical hydrocortisone oint... | I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that... | Inclusion Criteria:
1. Clinically diagnosed tennis elbow defined as: Pain on the lateral side of the elbow,
made worse by pressure applied on the lateral epicondyle of the humerus and during
resisted extension of the wrist or when making a fist with the elbow joint straight.
... | Finnish Tennis Elbow Trial Pilot Study | NCT02425982 | Contradiction |
5,364 | 40 | A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction. Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration. The patient has heavy menstrual cycles each month. She has no other medical problems and takes no medications... | I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical c... | Inclusion Criteria:
- Generally healthy non-smoking (for at least 3 months) adolescent females 12-16 years
of age with a history of at least 1 year of cyclic heavy menstrual bleeding (HMB)
- Subjects must report regularly occurring menstrual periods ≤10 days in duration, with
... | Lysteda Pediatric Research Equity Act (PREA) Pharmacokinetic Study in Adolescent Females With Heavy Menstrual Bleeding | NCT01190150 | Contradiction |
2,159 | 14 | A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain. The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medicat... | I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopuri... | Inclusion Criteria:
- Male or post-menopausal or surgically sterile female.
- 18 - 75 years of age.
- Hyperuricemic (i.e., screening sUA ≥8 mg/dL).
- Meets criteria for the diagnosis of gout as per the American Rheumatism Association
(ARA) Criteria for the Cl... | Gout Dose Response Study | NCT00955981 | Contradiction |
1,114 | 5 | A 23-year-old man comes to the emergency department following an episode of syncope. He was working out when he felt dizzy and passed out without head injury. He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has ... | I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special me... | Inclusion Criteria:
- Patients with primary cardiac hypertrophy, non-dilated LV cavity and preserved LV
systolic function, hence, the diagnosis of HCM, who have at least an LV end diastolic
(LVSD) wall thickness of at least 15 mm on a 2D echocardiogram and
- Known to ha... | Hypertrophic Regression With N-Acetylcysteine in HCM | NCT01537926 | Entailment |
592 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Request for elective abortion
- Ability to understand the consent form
- A pregnancy of 7 weeks gestation or less on Day 1
- Documented by endovaginal ultrasound
- Willingness to comply with visit schedules
Exclusion Criteria:
... | Comparing Methotrexate Followed by Misoprostol to Misoprostol Alone for Early Abortion | NCT00129506 | Entailment |
1,934 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
- Clinically diagnosed as early gastric cancer
- Willing to undergo endoscopic submucosal dissection or surgery for the treatment of
early gastric cancer
Exclusion Criteria:
- Advanced stage gastric cancer
- Not willing to undergo... | Endoscopic Submucosal Dissection Versus Surgery in the Treatment of Early Gastric Cancer | NCT03857737 | Entailment |
4,826 | 37 | A 47-year-old man comes to the office due to weight gain and fatigue. He is not able to lift heavy objects or climb stairs. Family history is positive for DM type 2 and HTN in his father. Blood pressure is 165/90 mm Hg and pulse is 85/min. On physical examination, there is symmetric proximal muscle weakness of the u... | I'm a 47-year-old man. I went to the clinic because I had been gaining weight and had increased fatigue over the past few weeks. I was not able to lift heavy objects or even climb the stairs. My dad was diagnosed with type 2 diabetes and high blood pressure. During the exam, they took my blood pressure, which was 165/9... | Inclusion Criteria:
- patients with both unilateral adrenal incidentaloma and hypercortisolism
- definition of hypercortisolism
- overnight dexamethasone suppression test, serum cortisol>1.8ug/dL
- 24hr urine cortisol > upper reference limit
Exclusion C... | Long-term Beneficial Metabolic Effects of Adrenalectomy in Subclinical Cushing's Syndrome of Adrenal Incidentaloma | NCT01382420 | Contradiction |
440 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
1. Menstruating females with menorrhagia or menometrorrhagia referred to hematology or
gynecology clinics at Texas Childrens Hospital. Menorrhagia is defined as regular
periods with heavy menstrual bleeding with a PBAC score greater than 100;
menomet... | Tranexamic Acid (TA) vs Combined Oral Contraceptive (COCP) Pilot Study | NCT01428713 | Contradiction |
1,848 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
- Endoscopically proven gastric adenocarcinoma
- Standard gastrectomy and a D2 lymph node dissection;
- Desire to attend the study protocol
Exclusion Criteria:
- Metastatic or overt peritoneal disseminated cancer
- Undesired reacti... | Serum and Peritoneal CEA and CA 19-9 for Gastric Adenocarcinoma | NCT02801955 | Entailment |
3,045 | 22 | A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination. The boy is going to a school for students with learning disabilities. The patient was adopted, and his immunizations are up to date. Review of the patient's medical records is notable for c... | My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it co... | Inclusion Criteria:
- aged between 12 and 18 years
- overweight and obesity
- mild or moderate intellectual disability
Exclusion Criteria:
- physical disability
- medical predispositions towards obesity (genetic syndrome or drug treatment)
... | School-based Physical Activity Intervention for Obesity Among Adolescents With Intellectual Disability in Hong Kong | NCT04463069 | Entailment |
3,999 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- At least one knee with osteoarthritis with Kellgren-Lawrence grade 3
- Significant osteoarthritis pain in the knee
- Presence of at least one of the risk factors: obesity (BMI > 28), osteoarthritis at
other sites, knee effusion, family history of to... | Safety/Efficacy of Balicatib (AAE581) in Adults With Osteoarthritis of the Knee | NCT00371670 | Entailment |
4,797 | 36 | A 47-year-old woman comes to the clinic complaining of dizziness. She also has occasional nausea and ringing in her right ear. The patient also has difficulty hearing while holding her phone to the left ear, although hearing in her right ear is normal. The dizziness improves spontaneously, and she feels fine between... | The other day, I had to go to the clinic due to severe dizziness. I'm 47 years old, and I've been suffering from nausea and ringing in my right ear. I also have difficulty hearing in my left ear while I hold my phone, even if my hearing in my right ear is normal. The dizziness just gets me all of a sudden but I don't h... | Inclusion Criteria:
1. 18-30 years old, male or female;
2. PTA (0.5,1,2kHz) ≤25dB HL;
3. Tinnitus is a major problem faced by patients (except healthy volunteers);
4. tinnitus course > for 3 months;
5. Healthy, no history of other ear diseases, no history of hearin... | Mechanism Research of Tinnitus Based on Electroencephalogram and Acoustic Therapy Intervention | NCT04449237 | Entailment |
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