id int64 3 7.01k | topic_id int64 1 50 | statement_medical stringclasses 50
values | statement_pol stringclasses 50
values | premise stringlengths 111 17k | NCT_title stringlengths 18 299 | NCT_id stringlengths 11 11 | label stringclasses 2
values |
|---|---|---|---|---|---|---|---|
3,630 | 28 | A 23-year-old woman comes to the emergency department with a history of nosebleeds lasting for 1 hour. She has a history of heavy menses as well as occasional gum bleeding following dental procedures. Her mother also has a history of menorrhagia. Laboratory tests reveal increased bleeding time and slightly increased pa... | I had to rush to the ER because of a non-stop nosebleed that had been on for 1 hour. As a 23-year-old, I always had heavy periods, and sometimes, my gums would bleed after going to the dentist or brushing my teeth. I thought that it was not very alarming since my mom also had heavy periods. I did some lab tests that sh... | Inclusion Criteria:
- Women between the ages of 18-45 (inclusive) not intending to get pregnant during the
next year
- Women complaining of heavy menstrual bleeding over several consecutive cycles
- Women without structural or histological abnormality of the uterus, or w... | Mirena or Conventional Medical Treatment for Menorrhagia | NCT00864136 | Entailment |
2,426 | 15 | An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity m... | I brought my 8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weak... | DMD-Patients
Inclusion Criteria:
- Histologic or genetically proven DMD
- Age 3-10 years
Exclusion Criteria:
-
Healthy controls
Inclusion Criteria:
- Male
- Age 3-10 years
Exclusion Criteria:
- Suspected mu... | Non-invasive Imaging of Muscle Structure in Duchenne Muscular Dystrophy Using Multispectral Optoacoustic Tomography | NCT03490214 | Entailment |
1,617 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | Inclusion Criteria:
- Age between 40-70 years at screening
- Proven hand OA by clinical examination and/or ultrasound
1. Clinical examination criteria: Heberden/Bouchards nodes and/or bony enlargement,
squaring and/or deformity of the thumb base and no clinical ... | The Nor-Hand Study | NCT03083548 | Contradiction |
79 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion Criteria:
- Successful completion of ZA-203
- Ability to understand and provide written informed consent
- Agreement to use a condom, and with a fertile female partner, another form of
contraception
- Agreement to provide semen samples in the clinic... | A One Year Open Label Study for the Treatment of Hypogonadism (Low Testosterone) in Men Who Have Completed ZA-203 | NCT01386567 | Contradiction |
3,933 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- Primary diagnosis of Functional Class I-III OA of the hip or knee
- Chronic user of nonsteroidal anti-inflammatory drugs (NDAIDs) and/or acetaminophen for
OA pain
- Discontinued all analgesic therapy at Screening
- For women of child-bea... | Study of Meloxicam Capsules to Treat Osteoarthritis Pain | NCT01787188 | Entailment |
1,142 | 5 | A 23-year-old man comes to the emergency department following an episode of syncope. He was working out when he felt dizzy and passed out without head injury. He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has ... | I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special me... | Group 1:
HCM patients, aged grater than 20 years of either gender who received DDD pacemakers at the
NIH at least 4 years ago, for relief of LVOT obstruction and drug-refractory symptoms.
Group 2:
HCM patients selected from Group 1 who at the follow-up cardiac catheterization are
... | Long-Term Results of DDD Pacing in Obstructive Hypertrophic Cardiomyopathy | NCT00001530 | Entailment |
5,393 | 40 | A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction. Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration. The patient has heavy menstrual cycles each month. She has no other medical problems and takes no medications... | I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical c... | Inclusion Criteria:
- Diagnosed with VWD
- Desmopressin acetate (DDAVP) treatment is ineffective or contraindicated or not
available
- Evidence of vaccination against hepatitis A and B (or presence of antibodies against
hepatitis A and B) within 10 years pri... | Study of a pd VWF/FVIII Concentrate, Biostate®, in Subjects With Von Willebrand Disease | NCT00941616 | Entailment |
3,832 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Main Inclusion Criteria:
- Diagnosed with knee osteoarthritis based on clinical and radiographic criteria of
American College of Rheumatology
- Grade 2 or 3 according to the criteria of Kellgren & Lawrence knee osteoarthritis
radiographic examination scale.
-... | Cryotherapy Associated With Exercise in Pain Control and Physical Function in Individuals With Knee Osteoarthritis | NCT03360500 | Entailment |
6,196 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- Tests negative for current or previous SARS-CoV-2 infection by RT PCR and serology
(Pre-exposure population only)
- Is at high risk of SARS-CoV-2 infection as assessed by the Investigator:
1. Post-exposure population: including, but not limited,... | Evaluation of ADG20 for the Prevention of COVID-19 | NCT04859517 | Contradiction |
1,744 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
- Dyspeptic adult outpatients
- Characteristic dyspeptic symptoms according to Rome III criteria (bothersome
postprandial fullness, early satiation, epigastric pain, or epigastric burning)
- Upper gastrointestinal endoscopy excluding structural diseas... | Lansoprazole for Subgroups of Functional Dyspepsia | NCT01040455 | Contradiction |
4,897 | 38 | A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago. It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amoun... | I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaki... | Inclusion Criteria:
- Participants must have been implanted with the DBS
- Participants must have been diagnosed with Essential Tremor
- Participants must experience negative side effects from their DBS which limit control
over their tremor
- Participants mus... | Relief From Side Effects: Clinical Use of Electrodes With Direction | NCT03795935 | Contradiction |
2,324 | 15 | An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity m... | I brought my 8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weak... | Inclusion Criteria:
- To be a Duchenne Muscular Dystrophy diagnosis,
- Being in the ambulatory period and climbing four steps independently,
- to be Level 1 and Level 2 according to Brooke Lower Functional Classification Test
- To be able to cooperate
- No any... | Regression of Hamstring Flexibility and Performance in Children With Duchenne Muscular Dystrophy | NCT03589612 | Entailment |
5,502 | 41 | A 61-year-old man comes to the emergency department complaining of an acute vision disturbance. He had an episode of vision disturbance in the right eye that occurred suddenly and resolved spontaneously in 15 minutes. He also has right jaw pain while chewing. He also complains of fatigue and hip muscle aches over the ... | I’m a 61-year-old man and I came to the ER because I had a sudden episode where I couldn’t see out of my right eye. It only lasted about 15 minutes and went away on its own but it really scared me. I’ve also been having pain in my right jaw when I chew. For the past few months I’ve felt really tired and noticed my hips... | Inclusion Criteria:
- Patients admitted to the Fondation Ophtalmologique Adolphe de Rothschild and suspected
to suffer from Horton disease, based on the presence of 3 or more major criteria, or 2
major criteria and at least one minor criteria.
Major criteria : Age > 50 ans... | Interest of Medical Imaging in the Diagnostic Strategy Vis a Vis a Suspected Horton Disease | NCT02473029 | Entailment |
2,941 | 21 | A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year. Over the last few months, he has also noticed weakness in the right upper extremity. BP is 120/75, PR is 80 and temperature is 37 C. Reflex... | I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rat... | Inclusion Criteria:
- Clinical diagnosis of ALS
- Taiwanese and used traditional Chinese(Mandarin).
- If they were older than age 20 years.
Exclusion Criteria:
- Frontotemporal dementia, severe depression, or schizophrenia.
- If they cannot complete t... | Development and Needs Assessment and Efficiency of Smart Communication System for Patients With ALS (Part 1) | NCT03806647 | Entailment |
3,750 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- 18-70 years
- Radiographic evidence of OA in the tibiofemoral compartment (minute or definite
osteophytes and a measurable joint space)
- Pain on walking (Visual Analogue Scale 0-10). Minimum of 4 and maximum of 9.
- Oxford knee score (O... | The Efficacy of Viscosupplementation for Early Knee Osteoarthritis | NCT01210742 | Contradiction |
5,465 | 40 | A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction. Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration. The patient has heavy menstrual cycles each month. She has no other medical problems and takes no medications... | I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical c... | Inclusion Criteria:
- Signed informed consent by the patient or next of kin or legally acceptable
representative to collect data on treatment of a given bleeding episode, surgical
event or prophylactic regimen as specified in the protocol.
- If informed consent is provi... | Treatment of Inherited Factor VII Deficiency | NCT01269138 | Entailment |
2,307 | 15 | An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity m... | I brought my 8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weak... | Inclusion Criteria:
- Molecular diagnosis of DMD
- Patients 7 - 10 years of age at time of screening
- Ambulant
Exclusion Criteria:
- Previous (3 months or less) or concomitant participation in another therapeutic trial
- Use of L-arginine, L-citrulli... | Improved Muscle Function in Duchenne Muscular Dystrophy Through L-Arginine and Metformin | NCT02516085 | Entailment |
256 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Age: ≥18 and <35 years old
- AFC: ≥5 and <20
- AMH: ≥1.1 ng/mL and <2.5 ng/mL
- BMI: ≥18.5 Kg/m2 and <29 Kg/m
- First or second ART cycle
- Regular menstrual cycles (between 22 and 35 days)
- Two ovaries present
... | Trigger Timing in Ovarian Stimulations | NCT04163133 | Contradiction |
70 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion Criteria:
healthy males
Exclusion Criteria:
use of anabolic steroids, use of narcotics,
Male
Accepts Healthy Volunteers
Subject must be at least 20 Years old.
Subject must be at most 30 Years | Testosterone-Dependent Effects on Protein Biomarkers From Healthy Males | NCT03541395 | Contradiction |
4,208 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | No eligibility criteria
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 21 Years | Effects of Chronic Ozone Exposure on Lung Function | NCT00006306 | Contradiction |
6,866 | 50 | A 70-year-old man comes to the office accompanied by his wife. The patient has experienced progressive memory loss over the last years. He needs help with some of his routine activities, such as paying bills. The patient's wife says, "He used to be such an independent person, but now he needs help with many things, ... | I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. M... | Inclusion Criteria:
- Male or female subjects aged 50-80 years.
- Lives with a significant other.
- Has subjective memory complaints. Verbal verification of this subjective memory
complaint will be obtained from the significant other.
- Has no severe, uncontr... | A Safety and Efficacy Study of Ispronicline (TC-1734-112) in Subjects With Age Associated Memory Impairment (AAMI) | NCT00109564 | Contradiction |
6,640 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria for Part 1:
1. Be male and ≥18 years of age;
2. Have clinically severe hemophilia A, defined as:
1. <1% (<1 IU/dL) endogenous FVIII activity levels as historically documented by a
certified laboratory or screening data results; OR
... | Dose-finding Study of SPK-8016 Gene Therapy in Patients With Hemophilia A to Support Evaluation in Individuals With FVIII Inhibitors | NCT03734588 | Contradiction |
5,924 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
- Danish adult patient with GERD-diagnosis verified by upper endoscopy 1997-2014
Exclusion Criteria:
- Any diagnosis of cancer in the gastrointestinal tract during follow-up
- Patients with GERD-diagnosis within previous four years or with concomitant dia... | Treatment of Newly Diagnosed Gastroesophageal Reflux Disease in a National Population-based Cohort | NCT03524781 | Contradiction |
1,100 | 5 | A 23-year-old man comes to the emergency department following an episode of syncope. He was working out when he felt dizzy and passed out without head injury. He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has ... | I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special me... | Patients of either gender, aged 18-80 years.
NYHA functional class III/IV, or syncope, or greater than or equal to 2 presyncope despite
verapamil and/or Beta-blocker therapy.
LV outflow tract gradient greater than or equal to 30 mm Hg at rest or greater than or
equal to 50 mm Hg follow... | A Comparison of Two Treatments: Pacemaker and Percutaneous Transluminal Septal Ablation for Hypertrophic Cardiomyopathy | NCT00001894 | Entailment |
3,455 | 25 | A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear. Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus. Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy s... | I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. ... | Inclusion Criteria:
- Adult Taiwanese outpatients with type 2 diabetes mellitus and high cholesterol
- Hemoglobin A1c levels of ≤10%, LDL-C levels of ≥130 mg/dL, and serum triglyceride
levels of <400 mg/dL
Exclusion Criteria:
- Type I diabetes mellitus
... | A Study To Evaluate The Safety And Efficacy Of Atorvastatin In Patients With Diabetes And High Cholesterol | NCT00645424 | Entailment |
5,341 | 40 | A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction. Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration. The patient has heavy menstrual cycles each month. She has no other medical problems and takes no medications... | I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical c... | - INCLUSION CRITERIA:
- Female gender - to evaluate effects in the target population for clinical trials
- History of abnormal uterine bleeding documented by menorrhagia impact questionnaire
(MIQ) and menstrual calendar
- Anovulatory and ovulatory women will be included... | CDB-2914 for Abnormal Uterine Bleeding in Premenopausal Women | NCT01493791 | Contradiction |
6,601 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- Male ≥18 years of age
- Severe hemophilia A (past evidence of circulating FVIII activity of < 1% normal)
- Treated or exposed to FVIII concentrates or cryoprecipitate for at least 150 exposure
days
- ≥12 bleeding episodes if receiving on... | A Study of Recombinant AAV2/6 Human Factor 8 Gene Therapy SB-525 (PF-07055480) in Subjects With Severe Hemophilia A | NCT03061201 | Contradiction |
3,150 | 23 | A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn. The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness. She also reports occasional joint pain. Medical history... | I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to t... | Inclusion Criteria:
1. 18 years old
2. Both sexes
3. Patients that diagnosis in sjogren in treated in Meir Medical center in the years
2003-2014 And treated in Hydroxychloroquine at least a month.
Exclusion Criteria:
1. Minors and special populations
... | the Effect of HCG Treatment as a Cardiovascular Disease Morbidity Factor in Sjogren Syndrome Patients | NCT02381587 | Contradiction |
2,749 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
- Male patients over 18 years of age who applied for inguinal hernia surgery
Exclusion Criteria:
- Patients under the age of 18
- Complicated hernias
- Recurrent hernias
- Those undergoing laparoscopic hernia repair
Male
Accepts He... | Can Ideal Mesh Size be Standardized in Open Inguinal Hernia Repair | NCT04280094 | Entailment |
2,452 | 16 | A 39-year-old woman comes to the clinic complaining of arthralgias and nodules on her legs. She has no fever or other skin rashes. The prior medical condition is unremarkable, and she takes no medications. On physical examination, there is moderate hepatomegaly. The lesions on her legs are tender and present predomin... | I'm just a 39-year-old young woman but lately I have noticed some underlying cysts on my legs and my joints were hurting so much. I don't have a fever. I don't have rashes. My medical history is totally clean and I don't take any medication. When I went to the clinic they did a physical examination where they found tha... | Inclusion Criteria:
- I1. Sufficiently conversant in the English language to satisfy I3.
- I2. Able and willing to comply with all study requirements.
- I3. Able and willing to provide written informed consent to participate (including by
parent or legal guardian if unde... | Vital Sign Comparison Between Lifelight and Standard of Care - Development | NCT04003662 | Entailment |
1,610 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | Inclusion Criteria:
- Chronic periodontitis (AAP 1999);
- ≥35 years of age;
- Presence of at least 15 teeth;
- Minimum of 6 teeth with at least one site each with PD and clinical attachment level
(CAL) ≥5 mm;
- At least 30% of the sites with PD an... | MTZ Plus AMX in the Treatment of Smokers and Non-smokers | NCT01837199 | Contradiction |
6,346 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | - INCLUSION CRITERIA:
For Phase A:
1200 persons who are recovering from an acute COVID-19 infection will participate.
Inclusion criteria for Phase A:
Post-COVID-19 Convalescence (n=1000)
1. Participants 18 and older
2. Ability to provide informed consent
... | Natural History of Post-Coronavirus Disease 19 Convalescence at the National Institutes of Health | NCT04573062 | Entailment |
4,291 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
- Men with Obstructive/Non-Obstructive Azoospermia who turned to sperm cell aspiration
for IVF and were found suitable for TEFNA and signed consent form.
Exclusion Criteria:
- healthy, non-azoospermic men
- men who are unsuitable for the TEFN... | Testis Needle Aspiration of Sperm in Men With Azoospermia | NCT02418832 | Entailment |
5,875 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
1. Age 18-80 years;
2. GERD for > 1 year;
3. History of daily PPIs for > 6 months;
4. At least daily bothersome medically refractory GERD symptom(s) other than heartburn on
PPIs;
5. Hill grade I and II at gastroesophageal junction;
... | The EndoGastric Solutions TEMPO Trial | NCT01647958 | Contradiction |
375 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Aged 18 years or more
- Menstruating women with regular menstrual cycle between 24 and 35 days and
intra-individual variations less than or equal to 5 days
- Request emergency contraception between 48 hours and 120 hours after unprotected
... | Safety and Efficacy of CDB-2914 for Emergency Contraception | NCT00411684 | Contradiction |
6,170 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
1. Adults ≥18 years of age.
2. COVID-19 positive by PCR and hospitalized for respiratory infection with a range of
respiratory severity as follows.
Moderate ● Diagnosed with SARS-CoV-2 infection by standard RT-PCR assay or equivalent
test... | Trial of Open Label Dipyridamole- In Hospitalized Patients With COVID-19 | NCT04424901 | Contradiction |
5,756 | 43 | A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers. The rashes are mildly itchy. The patient has no other medical conditions and takes no medications. Vital signs are normal. On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and a... | I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been ... | Inclusion Criteria:
- Clinically and Histologically proven painful Bullous/erosive or atrophic forms of OLP
Exclusion Criteria:
- lichenoid lesions
- Presence of systemic conditions
- Smoking
- Known hypersensitivity or severe adverse effects to the t... | Glucosamine as a Novel Adjunctive Therapy in Oral Lichen Planus | NCT02858297 | Contradiction |
2,214 | 14 | A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain. The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medicat... | I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopuri... | Inclusion Criteria:
- Male or female subjects aged 18 to 75 years (time of get informed consent)
- Meet the American College of Rheumatology/The European League Against Rheumatism
criteria (2015) for the classification of acute arthritis of primary gout
- Pain Visual Ana... | Efficacy and Safety of Simiaowan in Prevention of Acute Flares in Chronic Gout Patients Initiating Febuxostat Therapy | NCT04069325 | Contradiction |
81 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion Criteria:
- Adult male aged 20 to 40 years.
- Fluent in English.
Exclusion Criteria:
- Currently receiving hormonal therapy or testosterone boosting supplement.
- Has received hormonal therapy or testosterone boosting supplement within 3 months
... | EndogenousTestosterone Response to a Testosterone Boosting Supplement | NCT02600650 | Contradiction |
2,506 | 18 | A 2-year-old boy is brought to the office by his parents due to a rash that started 1 week ago. A similar red, itchy rash on the cheeks, trunk, and arms has occurred intermittently since infancy. The patient has had a few upper respiratory infections but no major illnesses. Vaccinations are up to date, and he takes ... | I just brought my two-year-old son to the doctor's office because he had a rash for like one week. His rash was on the cheeks, the trunk, and his arms. He already had this before, and it keeps coming back from time to time to time. In the past, he had some respiratory infections but he has never been this sick. His vac... | Inclusion Criteria:
- Patient oral and written informed consent
- Adult Caucasian patients (male and female) aged 18-69 years (both included);
- Patients smoking ≤ 10 cigarettes/day
- Patient has confirmed diagnosis of atopic dermatitis using the diagnostic features as
... | Efficacy, Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Study of the Topical Formulation SB011 Applied to Lesional Skin in Patients With Atopic Eczema | NCT02079688 | Contradiction |
2,850 | 21 | A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year. Over the last few months, he has also noticed weakness in the right upper extremity. BP is 120/75, PR is 80 and temperature is 37 C. Reflex... | I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rat... | Inclusion Criteria:
- Age: 25 to 80 years, inclusive
- Male or female subjects with probable or confirmed ALS (revised international El
Escorial criteria, Forbes et al., 2001).
- Patients presenting first motor deficits due to ALS for a maximum of three years at
... | Effect of MD1003 in Amyotrophic Lateral Sclerosis | NCT03114215 | Entailment |
4,410 | 34 | A 17-year-old male comes to the office due to several months of right elbow pain. The pain is worse with activity and limits his workouts and activities. He has tried over-the-counter medications with limited relief. Medical history is notable for eczema, and current medications include a topical hydrocortisone oint... | I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that... | Inclusion Criteria:
- spontaneous local pain over lateral epicondyle of the affected elbow for more than six
months and failure to respond to previous physical therapy or oral medications,
- local tenderness around the lateral epicondyle, and
- pain elicited or aggravate... | Comparison Between Steroid and Different Sites of Botulinum Toxin Injection in the Treatment of Lateral Epicondylalgia | NCT02767635 | Contradiction |
1,794 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
1. Age over or equal to 75 years
2. Primary gastric adenocarcinoma (papillary, tubular, mucinous, signet ring cell, or
poorly differentiated) confirmed pathologically by endoscopic biopsy, including
gastric multiple primary carcinoma
3. cT2-... | Clinical Outcomes of Laparoscopic D1 Versus D2 Lymphadenectomy for Elderly Patients With Advanced Gastric Cancer | NCT03290209 | Contradiction |
1,697 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | Inclusion Criteria:
- HV aged between 18 - 60 years
Exclusion Criteria:
- history of psychiatric disease or a positive first degree psychiatric family history
- pregnancy or lactation
- concomitant administration of any centrally activating medication (anti-depre... | Effects of Serotonin Agonist Citalopram on Multimodal Esophageal Stimulation in Healthy Volunteers | NCT04355455 | Entailment |
4,262 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
- Azoospermia
Exclusion Criteria:
- Absent or surgical removed testes
Male
No healthy subjects accepted to join the trial.
| Intra Testicular Artery Injection of Bone Marrow Stem Cell in Management of Azoospermia | NCT02008799 | Entailment |
1,028 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
1. Patients referred to the Leeds Community Healthcare Musculoskeletal service aged 45
years or over with primary symptoms suggestive of degenerative intraarticular knee
pain with a dominant mechanical presentation (i.e. activity related pain, functional
... | Joint Loading vs Normal Physiotherapy Care in Degenerative Knees (V1) | NCT02454374 | Entailment |
4,852 | 37 | A 47-year-old man comes to the office due to weight gain and fatigue. He is not able to lift heavy objects or climb stairs. Family history is positive for DM type 2 and HTN in his father. Blood pressure is 165/90 mm Hg and pulse is 85/min. On physical examination, there is symmetric proximal muscle weakness of the u... | I'm a 47-year-old man. I went to the clinic because I had been gaining weight and had increased fatigue over the past few weeks. I was not able to lift heavy objects or even climb the stairs. My dad was diagnosed with type 2 diabetes and high blood pressure. During the exam, they took my blood pressure, which was 165/9... | Inclusion Criteria:
- Major Inclusion Criteria:
- Have completed a Corcept-sponsored study of relacorilant in endogenous Cushing
syndrome with at least 80% compliance with the dosing schedule.
- According to the Investigator's opinion will benefit from con... | Extension Study to Evaluate the Safety of Long-Term Use of Relacorilant in Patients With Cushing Syndrome | NCT03604198 | Contradiction |
5,281 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Osteoporosis suspicion
Inclusion Criteria:
- Age: 50 - 59 years (n = 500) and 60-79 years (n = 500).
- Post-menopausal status.
- At least one of the clinical risk factors for fracture:
- Low body mass index (< 19kg/m2)
- Previous fragility f... | Point-of-care Osteoporosis Diagnostics With Bindex® Pocket Size Instrument and FRAX | NCT01998737 | Entailment |
4,215 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
- Adult patients with intractable dyspnea and PaO2>55mmHg in the setting of terminal
illness where the underlying cause has been maximally treated; a medical specialist
must document that all identified reversible causes of the dyspnea have been treated;
... | Palliative Oxygen for the Relief of Breathlessness | NCT00327873 | Contradiction |
490 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | IVF
Inclusion criteria:
- Women aged <43 years at the time of IVF treatment
Exclusion criteria:
- Preimplantation genetic diagnosis treatment
- Use of donor oocytes or donor embryos
- Hydrosalpinx shown on pelvic scanning and not surgically treated
... | GnRH Agonist for Dual Trigger in IVF and for Luteal Phase Support in FET | NCT04064840 | Contradiction |
268 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Women of good general health aged 18 - 35 years
- Not at risk of pregnancy
- Regular menstrual cycles of 24-35 days duration
- Not pregnant
- Intact uterus and ovaries
- Haemoglobin ≥ 11 g/dl
- Normal laboratory te... | Comparison of CDB-2914 Versus Placebo in the Prevention of Follicular Rupture Post-luteinizing Hormone (LH) Surge | NCT01107093 | Contradiction |
2,779 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
1. 21 years or older
2. No prior open abdominal surgery at or below the umbilicus
3. Primary or recurrent unilateral inguinal hernia repair
4. No previous preperitoneal mesh placement
5. BMI less than or equal to 40kg/m2
Exclusion Crite... | The Role of the Robotic Platform in Inguinal Hernia Repair Surgery | NCT02816658 | Entailment |
4,038 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- Patients diagnosed with knee osteoarthritis. The patients should have most problem
with their knees, but are allowed to have osteoarthritis in other lower extremity
joints.
- Independent in walking, with or without walking aids.
- Under... | Intra and Inter Reliability of 30 Seconds Chair Stand Test as Self-test for Patients With Knee Osteoarthritis. | NCT03855813 | Entailment |
4,528 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
1. Healthy sexually active women who have ever used an FC and using condoms (male or
female) as their current method of contraception.
2. Be 18 to 40 years at enrolment (inclusive).
3. Have a negative urine pregnancy test at enrolment visit.
4... | Randomized Comparative Study of the Contraceptive Efficacy of the Cupid, Cupid 2 and FC2 Female Condom | NCT04233632 | Contradiction |
5,650 | 42 | A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively. On physical examination, the patient's height is in the 5th percentile of her age. Other findings include low-set ears, a high arched palate... | I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a we... | Inclusion Criteria:
- Children ages 4 to 14 years with a height less than the 5th percentile for age and sex
or having a decelerated across two major percentiles (5th, 10th, 25th, 50th, 90th, and
95th) on standard pediatric growth curves, poor growth velocity (less than 5
... | rhGH Therapy on Hepatic Drug Metabolism | NCT00458991 | Contradiction |
6,265 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- Institutionalized people in nurswing homes since the beginning of the COVID19 epidemic
who do not have the infection present at the time of entering into the study.
- Healthcare professionals who provide direct care (nursing assistants and registered
... | Prevention of COVID19 Infection in Nursing Homes by Chemoprophylaxis With Hydroxychloroquine (PREVICHARM) | NCT04400019 | Contradiction |
576 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Singleton pregnancy.
- Primigravida or multigravida.
- Gestational age ≤ 20 weeks.
- Missed abortion.
Exclusion Criteria:
- Maternal age < 18 years.
- Twin pregnancy.
- Previous cesarean section.
... | Effectiveness of Pretreatment Letrozole Versus Misoprostol Alone in Missed Abortion | NCT04194658 | Entailment |
4,049 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- age between 45 and 65.
- Participants having Knee osteoarthritis grade 2 or higher "Kellgren and Lawrence
scale"
- Participants had an average pain intensity of grade 4 or more on a 10-point visual
analog for at least one year.
... | Knee Osteoarthritis Treatment With Adipose-derived Stem Cells: Phase II Clinical Trial | NCT03308006 | Entailment |
5,947 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
- Symptoms suggestive of GERD, with heartburn as their predominant symptom (described as
a burning feeling, rising from the stomach or lower part of the chest up towards the
neck), for longer than 6 months.
- Heartburn occurring for 4 days or more du... | Open, Randomised, Multi-center Study of on Demand Versus Continuous Esomeprazole Treatment in Patient With GERD | NCT02670642 | Contradiction |
4,533 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
- Aged 18 years or more
- Menstruating women with regular menstrual cycle between 24 and 35 days and
intra-individual variations less than or equal to 5 days
- Request emergency contraception between 48 hours and 120 hours after unprotected
... | Safety and Efficacy of CDB-2914 for Emergency Contraception | NCT00411684 | Contradiction |
2,456 | 16 | A 39-year-old woman comes to the clinic complaining of arthralgias and nodules on her legs. She has no fever or other skin rashes. The prior medical condition is unremarkable, and she takes no medications. On physical examination, there is moderate hepatomegaly. The lesions on her legs are tender and present predomin... | I'm just a 39-year-old young woman but lately I have noticed some underlying cysts on my legs and my joints were hurting so much. I don't have a fever. I don't have rashes. My medical history is totally clean and I don't take any medication. When I went to the clinic they did a physical examination where they found tha... | Inclusion Criteria:
1. Histologically proven sarcoidosis from any site (noncaseating granulomas without other
causes).
2. Diagnosis of active sarcoidosis (Sec. 5.5.4.t) clinical stage II by Chest X-ray (CXR).
3. Forced Vital Capacity (FVC) >45% and Diffusing Capacity for Ca... | Impact of Chemokine Receptor 5 (CCR5) Inhibition on Sarcoidosis Immunophenotypes | NCT02134717 | Entailment |
3,689 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- 60 years or older
- Having difficulty sleeping over the past three months (Insomnia Severity Index ≥ 8)
- Having osteoarthritis pain (Brief Pain Inventory Worst pain ≥ 4)
Exclusion Criteria:
- Working night shift
- Previously dia... | Audio-visual Stimulation for Sleep Promotion in Older Adults With Osteoarthritis Pain | NCT03441191 | Contradiction |
5,060 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
for the application with Dynaflex®:
- central or foraminal lumbar stenosis, Claudicatio spinalis pathology
- degenerative lumbar instability (e.g. Spondylolisthesis) with lumboischialgia or
Claudicatio spinalis pathology
- herniated vertebral... | "Examination of the Impact of a Dynamic Flexion Orthosis (Dynaflex®Ottobock) or of a Back Bandage (Lumbo Sensa®Ottobock) on the Voluntary Activation of the Back Muscles in Patients With Specific Back Pain" | NCT02536274 | Contradiction |
2,887 | 21 | A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year. Over the last few months, he has also noticed weakness in the right upper extremity. BP is 120/75, PR is 80 and temperature is 37 C. Reflex... | I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rat... | Inclusion Criteria:
- definite and/or probable diagnosis of ALS
- early stages of the disease
Exclusion Criteria:
- history of neuromuscular dysfunction not related to ALS
- active, confounding medical conditions
- unwillingness or inability to comply... | Study of the Effects Strengthening Exercises in Individuals With ALS | NCT00204464 | Entailment |
3,494 | 25 | A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear. Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus. Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy s... | I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. ... | Inclusion Criteria:
1. Subject is willing to give consent and comply with evaluation and treatment schedule;
2. 18 to 65 years of age (inclusive);
3. Have a BMI > 27 with one or more significant co-morbid medical conditions which are
generally expected to be improved, rever... | Resolution of Comorbidities, Safety and Efficacy of Greater Curvature Plication in Obese Patients. | NCT01512940 | Entailment |
164 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion Criteria:
1. Patients with ED over 3 months (specify using IIEF score)
2. Age >= 18 years.
3. Stable sexual relationship
4. With low or low normal serum testosterone level (either total or bioavailable
testosterone) TT <= 4 ng/ml and/or BT <= 1 ng/ml
... | The Therapy of Nebido as Mono or in Combination With PDE-5 Inhibitors in Hypogonadal Patients With Erectile Dysfunction | NCT00421460 | Entailment |
3,415 | 25 | A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear. Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus. Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy s... | I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. ... | Inclusion Criteria:
- 18 - 60 years old
- ASA (I and II)
- Hb level > 10 mg/dl
- elective ear exploratory tympanotomy surgery under general anesthesia.
Exclusion Criteria:
- Allergy to TXA
- bleeding/coagulation disorders
- psy... | Tranexamic Acid Versus Epinephrine During Exploratory Tympanotomy | NCT04188184 | Entailment |
1,714 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | Inclusion Criteria:
- ≥18 years of age
- Own an iOS or Android device
Exclusion Criteria:
- Inability to give informed consent
- <18 years of age
- Inability to understand written English language
- Hypertensive urgency or emergency as an ... | Role of Wrist Based Blood Pressure Monitoring in Clinical Practice | NCT03862742 | Entailment |
1,283 | 6 | A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea. The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease. He smokes 2 packs of cigarettes daily for the past 30 years. On examination, there are decreased breath sounds and percussive d... | I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my ... | Inclusion Criteria:
- Diagnosis of pleural effusion based on the presence of a consistent radiological
finding on simple posteroanterior and lateral chest X-rays, and decubitus lateral in
cases of small PE.
Exclusion Criteria:
- Non diagnosis of pleural effusio... | Effects of Respiratory Physiotherapy on Pleural Effusion | NCT01756742 | Entailment |
2,360 | 15 | An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity m... | I brought my 8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weak... | Inclusion Criteria:
- Diagnosed with Duchenne Muscular Dystrophy by a pediatric neurologist,
- Being volunteer,
- Being between 6 and 15 years old,
- Being between levels 1-5 according to the Brooke Lower Extremity Functional
Classification developed to class... | Effects of Fear of Falling on Physical Performance and Quality of Life in Children With Duchenne Muscular Dystrophy | NCT03507530 | Entailment |
1,713 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | Inclusion Criteria:
- Is the individual a healthy, normal adult man or woman who volunteers to participate?
- Is s/he within 18 to 45 years of age, inclusive?
- Is his/her BMI between 19 and 30 inclusive?
- Is she willing to avoid pregnancy by abstaining from sexual inter... | Bioequivalence Study of Desloratadine and Pseudoephedrine Extended-release Tablets Under Fed Conditions | NCT01506791 | Entailment |
5,645 | 42 | A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively. On physical examination, the patient's height is in the 5th percentile of her age. Other findings include low-set ears, a high arched palate... | I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a we... | Inclusion Criteria:
- Females with BMI >25 kg/m2.
- Females not engaged in routine exercise programs in last 6 months
Exclusion Criteria:
- Females who are using weight loss products.
- Females having uncontrolled diabetes, thyroid disease, arthritis, cardiac dis... | Effect of HICT and LIIT on Functional Strength and Weight Efficacy in Overweight and Obese Females | NCT04812340 | Contradiction |
822 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- Presence of osteophytes or sclerosis at the carpometacarpal (CMC) joint
- Complaint of unacceptable pain despite modification of activity and a therapeutic dose
of nonsteroidal anti-inflammatory drugs (NSAIDS), if tolerated
- If bilateral disease, o... | A Study of Hyaluronan for the Treatment of Osteoarthritis in the Thumb | NCT00398866 | Entailment |
4,024 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- Able to provide written informed consent to participate in the study;
- Willing and able to comply with all study requirements and instructions of the site
study staff;
- Male or female, 40 years to 85 years old (inclusive);
- Must be am... | AP-003-B Study to Evaluate the Efficacy And Safety Of An Intra-Articular Injection Of Ampion™ In Adults With Pain With Osteoarthritis Of The Knee | NCT02556710 | Entailment |
4,888 | 37 | A 47-year-old man comes to the office due to weight gain and fatigue. He is not able to lift heavy objects or climb stairs. Family history is positive for DM type 2 and HTN in his father. Blood pressure is 165/90 mm Hg and pulse is 85/min. On physical examination, there is symmetric proximal muscle weakness of the u... | I'm a 47-year-old man. I went to the clinic because I had been gaining weight and had increased fatigue over the past few weeks. I was not able to lift heavy objects or even climb the stairs. My dad was diagnosed with type 2 diabetes and high blood pressure. During the exam, they took my blood pressure, which was 165/9... | PROTOCOL ENTRY CRITERIA:
- Patients aged 20 to 60 with spontaneous active Cushing's syndrome
- At least 2 weeks since medication with psychoactive effects or influence on cortisol
metabolism by hepatic hydroxylating enzyme induction
- Antihypertensives allowed for severe... | Study of Depression, Peptides, and Steroids in Cushing's Syndrome | NCT00004334 | Entailment |
1,575 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | Inclusion Criteria:
1. Age ≥ 21 years and ≤ 85 years
2. Able to understand and give informed consent.
3. Subject is presenting for the following planned procedures:
3.1 Group A (25 subjects): Subjects presenting for catheter ablation for cardiac
arrhythmias (e.g. atrial... | iBeat Wristwatch Validation Study | NCT03711695 | Contradiction |
4,351 | 33 | A 20-year-old man comes to the clinic for his routine checkup. The patient wears glasses for myopia and takes no medications. Vital signs are normal. On physical examination, the patient is tall with long upper extremities and fingers. The face appears narrow with down-slanted palpebral fissures, flattened malar bon... | I'm a 20-year-old guy, working as a driver and I went to the clinic for my routine checkup. I have myopia, so I wear glasses and I don't take any other medications. My vitals were normal. I also did a physical exam, and I was told that I have long legs, arms, and fingers. They also told me that my face is quite narrow,... | Inclusion Criteria:
- 18 to 39 years of age
- Best corrected visual acuity of at least 20/30
- Spherical equivalent refractive error in each eye of between -0.75 and -6.00 diopters
sphere after vertexing to the corneal plane
Exclusion Criteria:
- Gre... | Evaluation of Visual Performance With Contact Lenses | NCT03705130 | Entailment |
3,491 | 25 | A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear. Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus. Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy s... | I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. ... | Inclusion Criteria:
- Sudden hearing loss, ototoxic hearing loss, noise-induced hearing loss, meniere's
disease patients with 25dB HL in pure tone audiometry
- Patients whose hearing has not been restored after standard treatment
- Patients do not participate in clinical... | Verification of the Efficacy/Safety of the Dual Drug Delivery for Hearing Loss | NCT04766853 | Entailment |
3,284 | 23 | A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn. The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness. She also reports occasional joint pain. Medical history... | I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to t... | Inclusion Criteria:
- Patients: cross sectionally patients will be included for clinical suspicion of
primary SS or with the diagnosis already established in Rheumatology unit.
The following inclusion criteria will be applied to the study:
- Age > 18 years
- Inf... | Biomarkers in Primary Sjögren's Syndrome | NCT03765593 | Entailment |
6,852 | 49 | A 50-year-old woman comes to the clinic complaining of difficulty swallowing both liquids and solid foods, as well as occasional cough while eating. She also has difficulty lifting her arms above her head and getting up from a chair. The weakness seems to get worse gradually. The patient has no prior medical problems ... | I had to go to the clinic because of difficulty swallowing all kinds of food, liquid and solid. I also sometimes cough when I eat my dinner. At only 50 year old, I had some difficulties lifting up my arms and getting up from a chair! And it's only getting worse! I never had any medical issues in the past and I'm not un... | Inclusion Criteria:
- referral by a physician for swallowing evaluation because of suspected dysphagia
- complaint of difficulty swallowing
- aspiration or penetration of the laryngeal vestibule with liquids or semisolids OR
post-swallow residue visible in the oral cavit... | Study of Tongue Strengthening for Swallowing Problems | NCT01570023 | Entailment |
3,571 | 27 | A 31-year-old woman comes to the office due to 3 days of rash on her left arm. The lesion is mildly pruritic but not painful. She is otherwise healthy and occasionally takes ibuprofen during the first few days of her menstrual period. Temperature is 37 C, blood pressure is 110/75 mm Hg, and pulse is 95/min. The lesi... | I went to the clinic because I had a rash on my left arm for three days, and the lesion started to be putrid, but it was not painful. I'm a 31-year-old healthy woman and the only medication I use is ibuprofen when I get my periods. They took my temperature, which turned out to be 37°C and took my blood pressure which w... | Inclusion Criteria:
- erythema migrans in patients > 18 years
Exclusion Criteria:
- pregnancy or immunocompromising conditions
- taking antibiotic with antiborrelial activity within 10 days
No condition on gender to be admitted to the trial.
No healthy subjects accepted to j... | Inflammatory Mediators in Erythema Migrans | NCT03956212 | Entailment |
2,531 | 18 | A 2-year-old boy is brought to the office by his parents due to a rash that started 1 week ago. A similar red, itchy rash on the cheeks, trunk, and arms has occurred intermittently since infancy. The patient has had a few upper respiratory infections but no major illnesses. Vaccinations are up to date, and he takes ... | I just brought my two-year-old son to the doctor's office because he had a rash for like one week. His rash was on the cheeks, the trunk, and his arms. He already had this before, and it keeps coming back from time to time to time. In the past, he had some respiratory infections but he has never been this sick. His vac... | - INCLUSION CRITERIA:
1. Subject or unaffected relatives must:
1. Be at least 2 years of age and less than or equal to 21 years of age at the
time of enrollment and have documented history of AD, by modified Hanifin
and Rajka criteria, ... | Natural History of Diseases Associated With Allergic Inflammation: Atopic Dermatitis and Genetic and Congenital Diseases Associated With Atopic Pathways | NCT01164241 | Entailment |
1,621 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | - INCLUSION CRITERIA:
- Participation in the NLM / NAO Teen Health Information Literacy Project
EXCLUSION CRITERIA:
-NA
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 13 Years old.
Subject must be at most 18 Years | Educational Impact of the NLM/National Area Health Education Center Organization (NAO) Project-SHARE Based Teen Health Information Literacy Curriculum | NCT02769988 | Contradiction |
2,829 | 21 | A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year. Over the last few months, he has also noticed weakness in the right upper extremity. BP is 120/75, PR is 80 and temperature is 37 C. Reflex... | I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rat... | Inclusion Criteria:
- ALS patients diagnosed according to El Escorial / Awaji criteria for ALS
- patients should have the ability to comprehend the full nature and purpose of the
study, to cooperate with the investigator, to understand verbal and written
instructions, a... | Evaluating the Potential of the Diet as Disease Modifier in Amyotrophic Lateral Sclerosis (JERN_ALS) | NCT02572479 | Entailment |
6,375 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- Male or female, aged ≥18 years of age;
- Laboratory confirmed infection with COVID-19 virus by an FDA-authorized SARS-Cov-2
RT-PCR;
- Able and willing to give written informed consent.
- Willing to keep an electronic diary from Study Day... | Tafenoquine in Patients With Mild to Moderate COVID-19 | NCT04533347 | Entailment |
313 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Regular menstrual cycles
- Age 18-50
- Normal Baseline ultrasound
- No intra-uterine procedures in prior 90 days
Exclusion Criteria:
- Any contraindications to undergoing estrogen stimulation of the endometrium
- Age ... | Effects of Varied Estrogen Doses on Endometrial Receptivity | NCT02458404 | Contradiction |
5,156 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion criteria:
Caucasian
BMI of 18.5 kg/m2 or above
Ages 25 to 40 years (and premenopausal if female) or 55 to 75 years (and postmenopausal (at
least 5 years since last menstrual period) if female)
Sufficiently mobile to undergo scanning
Able to remain motionles... | The Effects of Obesity on Bone Structure and Strength | NCT02629185 | Contradiction |
6,533 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- Willingness to adhere to the clinical protocol and 15-year long-term follow-up as
evidenced by written informed consent
- Adult males at least 18 years of age
- A. Severe FIX deficiency (<1% normal circulating FIX) or B. Moderately severe FIX
... | Hemophilia B Gene Therapy With AAV8 Vector | NCT01620801 | Contradiction |
3,559 | 27 | A 31-year-old woman comes to the office due to 3 days of rash on her left arm. The lesion is mildly pruritic but not painful. She is otherwise healthy and occasionally takes ibuprofen during the first few days of her menstrual period. Temperature is 37 C, blood pressure is 110/75 mm Hg, and pulse is 95/min. The lesi... | I went to the clinic because I had a rash on my left arm for three days, and the lesion started to be putrid, but it was not painful. I'm a 31-year-old healthy woman and the only medication I use is ibuprofen when I get my periods. They took my temperature, which turned out to be 37°C and took my blood pressure which w... | Inclusion Criteria:
- age 18-35 years
- female
- Informed Consent as documented by signature (Appendix Informed Consent Form)
Exclusion Criteria:
- itchy skin diseases
- hay fever
- asthma
- chronic venous insufficiency
... | The Mysterious on/Off Itch and Erythema During Whole Body Vibration Exercise | NCT03455036 | Contradiction |
3,216 | 23 | A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn. The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness. She also reports occasional joint pain. Medical history... | I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to t... | - INCLUSION CRITERIA:
Male and female subjects.
All subjects will have first participated in screening protocol 84-D-0056 to confirm their
diagnosis and assess salivary function.
Subjects must have dry mouth symptoms (xerostomia) and a diagnosis of primary or secondary
SS, in... | Natural History of Salivary Gland Dysfunction and Sjogren's Syndrome | NCT00001852 | Entailment |
411 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- healthy, non-pregnant, pre-menopausal female who is not using NuvaRing.
- must meet one of the two following criteria: 1) has not taken a combined hormonal
contraceptives for at least 3 months prior to screening and has normal predictable
menstrual... | Performance and Safety of Vaginal Ring Applicator in Healthy Females (MK-8342A-063) | NCT02275546 | Contradiction |
855 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- Patient suffering with Osteoarthritis knee for three months at least
- Age ranges from 40-70
- knee OA as per the American College of Rheumatology clinical and radiographic
diagnostic criteria will participate
- 1-3 radiographic grades o... | Retro-walking in Knee Osteoarthritis | NCT04546659 | Entailment |
927 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- Hand OA diagnosis according to the criteria of the American College of Rheumatology
(ACR )
- Be properly registered in the rheumatology clinic of Hospital das Clínicas
Exclusion Criteria:
- Surgical treatment or infiltration in the hands, i... | Assistive Device for Hand Osteoarthritis | NCT02667145 | Entailment |
6,292 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- Are currently not hospitalized. (Not applicable to participants in treatment arm 22.)
- Have one or more mild or moderate COVID-19 symptoms: Fever, cough, sore throat,
malaise, headache, muscle pain, gastrointestinal symptoms, or shortness of breath with
... | A Study of LY3819253 (LY-CoV555) and LY3832479 (LY-CoV016) in Participants With Mild to Moderate COVID-19 Illness | NCT04427501 | Entailment |
2,691 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
- ages must be upper 18
Exclusion Criteria:
- Morbit obesity (BMI>40)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years | Normal and Small Size Mesh in Open Inguinal Herni Repair | NCT04269330 | Entailment |
6,960 | 50 | A 70-year-old man comes to the office accompanied by his wife. The patient has experienced progressive memory loss over the last years. He needs help with some of his routine activities, such as paying bills. The patient's wife says, "He used to be such an independent person, but now he needs help with many things, ... | I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. M... | Inclusion Criteria:
- Outpatients with a diagnosis of Alzheimer's disease.
- Exhibiting an onset and progression of cognitive dysfunction during at least 3 months
prior to the screening period.
Exclusion Criteria:
- Patients with neurodegenerative diseases other... | Effects of Chromium on Insulin Resistance in Alzheimer Disease Patients | NCT03038282 | Entailment |
1,002 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- patients with grade I or grade II knee OA (based on the Kellgren-Lawrence
classification;
- which was diagnosed by a medical traumatologist;
- radiographic changes that demonstrated a reduced joint space in at least one of the
compartme... | Exercise and Muscle Stimulation in Patients With Knee Osteoarthritis | NCT01320904 | Entailment |
5,079 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
Ambulatory, postmenopausal Japanese women with osteoporosis (defined as bone mineral
density T-score of ≤ -4.00 at the lumbar spine or BMD T-score of ≤ -3.50 at the total hip,
or femoral neck)
Exclusion Criteria:
- Severe osteoporosis
- Use o... | Efficacy, Safety and Tolerability of Romosozumab in the Treatment of Japanese Women With Postmenopausal Osteoporosis | NCT01992159 | Contradiction |
1,935 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
1. Age from over 18 to under 75 years
2. Primary gastric adenocarcinoma (papillary, tubular, mucinous, signet ring cell, or
poorly differentiated) confirmed pathologically by endoscopic biopsy
3. cT1-4a(clinical stage tumor), N-/+, M0 at preoperative eva... | Clinical Outcomes of Robotic Versus Laparoscopic Distal Gastrectomy for Gastric Cancer | NCT03313700 | Entailment |
2,935 | 21 | A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year. Over the last few months, he has also noticed weakness in the right upper extremity. BP is 120/75, PR is 80 and temperature is 37 C. Reflex... | I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rat... | [Inclusion Criteria]
1. Subjects who show both upper motor neuron signs and lower motor neuron signs at the
same time in neurological tests.
2. Among subjects diagnosed with familial or sporadic ALS, subjects falling into
clinically definite ALS, probable ALS and probable... | Evaluatiton the Efficacy and Safety of Mutiple Lenzumestrocel (Neuronata-R® Inj.) Treatment in Patients With ALS | NCT04745299 | Entailment |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.