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2,478 | 17 | A 67-year-old man comes to the clinic with slowly worsening vision in both eyes. He is not able to drive at night, as the symptoms are worse at night. His pupils are normal in diameter both in the light and darkness. Other medical history is unremarkable. Ocular examination shows loss of the red reflex and blurry vis... | I am a 67 years-old man, and I haven't been able to drive at night due to my vision getting worse. My vision is not the best in general, but night makes it even worse. The ophthalmologist told me that my pupils were normal. However, I have slow reflexes and blurry vision. My acuity test came back with 50/100 vision in ... | Inclusion Criteria:
- 10 years or older and healthy
- No eye diseases
Exclusion Criteria:
- Patients with glaucoma, macular degeneration, diabetic retinopathy, corneal disease,
eye movement disorders or any eye disease causing vision loss
- Patients ... | Building a Database of Results From People Without Eye Problems | NCT02627339 | Contradiction |
3,926 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion criteria for OA patients:
1. Kellgren-Lawrence radiological grade of 1-3 in at least one tibio-femoral joint
diagnosed by screening x-ray.
2. 35 to < 75 years of age at the time of signing the informed consent form.
3. Bodyweight > 50 and < 150 kg and a BMI in the... | The Effect of Exercise on Serum Levels of Collagen and Proteoglycan in Patients With Knee Osteoarthritis (EFEX-OA-01) | NCT04542655 | Entailment |
156 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion Criteria:
- Male ages 18-68 years diagnosed as having testosterone deficiency with clinical
symptoms
- A morning (8:00-10:00) serum Total Testosterone concentration of ≤ 300 ng/dL,
confirmed by a second measurement of morning serum Total Testosterone concentra... | Testogel® (Testosterone Gel 50mg/5g) in the Treatment of Male Hypogonadism | NCT01786473 | Entailment |
2,059 | 12 | A 47-year-old man comes to the office for routine checkup. He is complaining of chronic cough and occasional but progressive dyspnea. Other medical conditions include hypertension and osteoarthritis. The patient smokes a pack of cigarettes daily and does not use alcohol or illicit drugs. He used to be a construction... | I'm a 47-year-old former construction worker. I'm a man and I smoke a pack of cigs a day but I don't drink or do drugs. I went to my routine checkup because I've been coughing so much lately. I also had shortness of breath and it got worse over time. I already suffer from hypertension and osteoarthritis. My doctor foun... | Inclusion Criteria:
- Women or men age 50 to 79 years
- history of exposure to asbestos at work and one or more of the following:
- lung cancer risk ≥2% over 3 years or
- asbestosis or pleural plaques on a chest x-ray or
- abnormal auto-antibodi... | Early Detection of Lung Cancer and Mesothelioma in Workers Exposed to Asbestos | NCT01719068 | Contradiction |
6,749 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- Patients diagnosed with hemophilia A and B
- Patients with a medical diagnosis of hemophilic arthropathy and pain
- People over 18 years of age
- Patients on prophylactic or on-demand treatment regimen with FVIII / FIX concentrates
Exclusion... | Movement Visualization in Pain Management in Patients With Hemophilic Arthropathy. | NCT04549402 | Contradiction |
2,513 | 18 | A 2-year-old boy is brought to the office by his parents due to a rash that started 1 week ago. A similar red, itchy rash on the cheeks, trunk, and arms has occurred intermittently since infancy. The patient has had a few upper respiratory infections but no major illnesses. Vaccinations are up to date, and he takes ... | I just brought my two-year-old son to the doctor's office because he had a rash for like one week. His rash was on the cheeks, the trunk, and his arms. He already had this before, and it keeps coming back from time to time to time. In the past, he had some respiratory infections but he has never been this sick. His vac... | Inclusion Criteria:
- ≥13 to 65 years of age (inclusive), male or female
- Able to understand protocol and give consent
- Able to keep clinic/study appointments and comply with study related procedures
- Must be able to read, speak, and understand English
- Ch... | Study of Skin Microbiome in Atopic Dermatitis Patients | NCT04170244 | Contradiction |
4,947 | 38 | A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago. It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amoun... | I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaki... | Inclusion Criteria:
- Patients with medical refractory essential tremor or tremor-dominant Parkinson's
disease that are not candidates for deep brain stimulation (DBS), either by
medical/surgical co-morbidities or by choice.
- Patients must have an ECOG status of 0, 1, ... | RAD 1601: EDGE Radiosurgery for Intractable Essential Tremor and Tremor-Dominant Parkinson's Disease | NCT03305588 | Entailment |
4,375 | 33 | A 20-year-old man comes to the clinic for his routine checkup. The patient wears glasses for myopia and takes no medications. Vital signs are normal. On physical examination, the patient is tall with long upper extremities and fingers. The face appears narrow with down-slanted palpebral fissures, flattened malar bon... | I'm a 20-year-old guy, working as a driver and I went to the clinic for my routine checkup. I have myopia, so I wear glasses and I don't take any other medications. My vitals were normal. I also did a physical exam, and I was told that I have long legs, arms, and fingers. They also told me that my face is quite narrow,... | Inclusion Criteria:
Volunteers may be eligible for this trial if they:
- Are able to and have given informed consent.
- Are able to understand and comply with all study procedures and to complete study
diary.
- Are aged 18 to 49 years.
- Are female, ... | Half-Dose Flu Vaccine Study in Healthy Adults | NCT00006146 | Entailment |
1,009 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- Individuals (and family members) with early onset osteoarthritis according to the
following definition:
- symptomatic OA before 50 years old
- no obvious causes of OA (IMC > 30, dysplasia,joint traumas)
- at least three OA... | Phenotype/Genotype Correlation in a Family With Early Onset Osteoarthritis | NCT01999166 | Entailment |
5,695 | 42 | A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively. On physical examination, the patient's height is in the 5th percentile of her age. Other findings include low-set ears, a high arched palate... | I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a we... | Inclusion Criteria:
- Over weight / obese children
- Normal weight children
Exclusion Criteria:
- Organic disease that cause obesity
- Underweight children (BMI percentiles < 5)
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subjec... | Specially Designed Eating Plates Effects on Food Intake in Normal Weight and Overweight Children | NCT02166892 | Entailment |
1,796 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | INCLUSION CRITERIA:
- Any cachectic patient with weight loss presumed secondary to cancer or cancer related
therapy is eligible. Cachexia is defined as having one or more of the following:
- documented history of weight loss > 5%
- drop in growth rate two or more percent... | Cyproheptadine and Megestrol in Preventing Weight Loss in Children With Cachexia Caused By Cancer or Cancer Treatment | NCT00066248 | Contradiction |
2,823 | 21 | A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year. Over the last few months, he has also noticed weakness in the right upper extremity. BP is 120/75, PR is 80 and temperature is 37 C. Reflex... | I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rat... | Inclusion Criteria:
- All subjects must have a verifiable diagnosis of ALS of 0.5 to 2 years' duration. The
diagnosis must be supported by the Revised Criteria of the World Federation of
Neurology. The grades of diagnosis must be clinically definite ALS or clinically
p... | G-CSF Treatment for Amyotrophic Lateral Sclerosis: A RCT Study Assessing Clinical Response | NCT00397423 | Entailment |
3,603 | 28 | A 23-year-old woman comes to the emergency department with a history of nosebleeds lasting for 1 hour. She has a history of heavy menses as well as occasional gum bleeding following dental procedures. Her mother also has a history of menorrhagia. Laboratory tests reveal increased bleeding time and slightly increased pa... | I had to rush to the ER because of a non-stop nosebleed that had been on for 1 hour. As a 23-year-old, I always had heavy periods, and sometimes, my gums would bleed after going to the dentist or brushing my teeth. I thought that it was not very alarming since my mom also had heavy periods. I did some lab tests that sh... | Inclusion Criteria:
- Are overtly healthy
- Body mass index (BMI) of 18.5 to 35 kilograms per meter squared (kg/m²)
Exclusion Criteria:
- have known allergies to lasmiditan, dabigatran, rosuvastatin-related compounds or any
components of the formulation of lasmi... | A Study of Lasmiditan in Healthy Volunteers | NCT04749914 | Contradiction |
6,039 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
1. Patients of either sex aged 18-80 years.
2. Diagnosis of functional dyspepsia according to Rome III criteria:
- Pain or burning localized to the epigastrium of at least moderate severity at
least once per week with a total duration of at le... | Study in Patients Suffering From Heartburn and Backward Flow of Stomach Liquid Into the Esophagus | NCT04059900 | Entailment |
6,813 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
1. Children (≥ 13 years old) and adult male and female subjects who provide written
informed consent and assent.
2. Subjects must be willing to use the mobile device and answer questions regarding their
experience.
Exclusion Criteria:
... | Mobile Biosensor for Measuring Vital Signs in Healthcare and Home Settings | NCT04233827 | Entailment |
2,356 | 15 | An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity m... | I brought my 8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weak... | Inclusion Criteria:
1. Has provided written informed assent (as required by EC) and parents/guardians have
provided written informed consent.
2. Has an out-of-frame deletion(s) that could be corrected by skipping exon 51 based on
DNA sequencing data from the candidate.
... | Dose-Ranging Study of AVI-4658 to Induce Dystrophin Expression in Selected Duchenne Muscular Dystrophy (DMD) Patients | NCT00844597 | Entailment |
4,891 | 37 | A 47-year-old man comes to the office due to weight gain and fatigue. He is not able to lift heavy objects or climb stairs. Family history is positive for DM type 2 and HTN in his father. Blood pressure is 165/90 mm Hg and pulse is 85/min. On physical examination, there is symmetric proximal muscle weakness of the u... | I'm a 47-year-old man. I went to the clinic because I had been gaining weight and had increased fatigue over the past few weeks. I was not able to lift heavy objects or even climb the stairs. My dad was diagnosed with type 2 diabetes and high blood pressure. During the exam, they took my blood pressure, which was 165/9... | Inclusion Criteria:
- Written consent
- Age between 18 and 70
- Diagnosed with Cushing's syndrome
Exclusion Criteria:
- Suspected malignancy
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at lea... | Insulin Sensitivity and Substrate Metabolism in Patients With Cushing's Syndrome | NCT00682084 | Entailment |
3,684 | 29 | A 57-year-old man comes to the emergency department due to constipation. His last bowel movement was 2 days ago. He complains of spending about 30 minutes once attempting to defecate. He also has lower back pain. There is no history of trauma. The pain is not relieved with over-the-counter pain medications. His vita... | I'm a 57 year-old-man, and I had to go to the ER because I couldn't go defecate. My last trip to the toilet was 2 days ago, and I tried too many times, during 30 min, to get my poop to get out. I also have terrible lower back pain. The doctor did not notice any trauma. I tried to get the pain away using over-the-counte... | Inclusion Criteria:
- healthy volunteers
- patients with spinal lesion
- patients with cauda equina syndrome
Exclusion Criteria:
- pregnant women
- pacemaker or other metallic material implanted
- epileptic patients
- organic c... | Study of the Nervous Control of the Anal Sphincter | NCT00213356 | Entailment |
3,396 | 25 | A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear. Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus. Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy s... | I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. ... | Inclusion Criteria:
- 18 years to 75 years of age;
- Stabilized on atorvastatin 10 mg daily and by subject reported history had taken at
least 80% of daily doses for the 4 weeks preceding Visit 1;
- LDL-C concentration greater than or equal to 2.5 mmol/L to less than or ... | Switching to Rosuvastatin Versus Adding Ezetimibe to Atorvastatin Versus Doubling the Dose of Atorvastatin in Patients With Hypercholesterolemia and Risk Factors (P03708) | NCT00651378 | Contradiction |
1,949 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria - Phase 2 Part
1. Subjects of respective country's legal age or older at the time of written informed
consent.
2. Subjects with histologically confirmed inoperable locally advanced, recurrent, or
metastatic adenocarcinoma of the stomach or GEJ cancers m... | Varlitinib in Combination With mFOLFOX6 for Advanced or Metastatic Gastric Cancer (First Line) | NCT03130790 | Entailment |
5,290 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- prior fracture
- osteoporosis diagnosis
- received home health care
Exclusion Criteria:
- hospice
- active cancer treatment
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subje... | Improving Osteoporosis Care in a Home Health Setting | NCT01109472 | Entailment |
4,240 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
1. Provision of signed and dated written informed consent prior to any study specific
procedures.
2. Healthy male or female subjects aged 18 to 50 years (inclusive) at screening with
suitable veins for cannulation or repeated venepuncture.
3... | Single + Multiple Ascending Dose and Food Effect Study of AZD7986 in Healthy Volunteers, PK, PD and Safety Study | NCT02303574 | Contradiction |
2,899 | 21 | A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year. Over the last few months, he has also noticed weakness in the right upper extremity. BP is 120/75, PR is 80 and temperature is 37 C. Reflex... | I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rat... | Inclusion Criteria:
- ALS patients
- > 18 years
- Participation in the cohort study
Exclusion Criteria:
- Refusal of participating in the cohort study
- Presence of PEG
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Sub... | Chewing Efficiency Measured by a Two Colour Chewing Gum Test in Amyotrophic Lateral Sclerosis (ALS) Patients? | NCT01772888 | Entailment |
2,656 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
- men between 30-75 years of age
- ASA class I-II
- primary unilateral inguinal hernia
Exclusion Criteria:
- lower midline incision below linea arcuate
- large scrotal hernia
- previously or current abuse,mental disease... | Study Comparing Total Extraperitoneal Patch "TEP" Versus Lichtenstein According Chronic Pain | NCT00803985 | Entailment |
808 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- Cases of knee joint degeneration diagnosed by orthopedics, rheumatology and immunology
physicians.
- X-ray interpretation (kellgren & Lawrence grade) grades 1 to 3 or mild to moderate
patients.
- Willing to sign written consent form.
... | Effects of Diet Control and Resistance Exercise Training on Obesity Adults With Knee Osteoarthritis | NCT03973463 | Entailment |
23 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion Criteria:
- Adult male patients (above 18 years old and below 60 years old)
- Receiving greater than 20 IV morphine equivalents/day with <20% change in dosage in
the last month.
- AM total testosterone <300 ng/dL
- Report "worst pain during the past... | Analgesic Efficacy of Testosterone Replacement in Hypogonadal Opioid-Treated Chronic Pain Patients: A Pilot Study. | NCT00398034 | Contradiction |
5,282 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- DXA (dual energy X-ray absorptiometry) T-score known clinically to be = or < -2.5 OR
presence of low-energy osteoporotic fractures (i.e. excluding those of the skull,
fingers and toes) [for osteoporosis and calcium malabsorption patients]
Exclusion Cr... | Study of the Diagnostic Value of Stable Calcium Isotope Profiling in Bone and Calcium Disorders | NCT02252679 | Entailment |
1,890 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
- Histologically confirmed adenocarcinoma of the stomach, the esophagus or the
gastroesophageal junction
- Inoperable locally advanced disease, resections with R0, R1 or R2 outcome or
metastatic disease.
- CLDN18.2 expression confirmed by... | Safety and Activity of IMAB362 in Combination With Zoledronic Acid and Interleukin-2 in CLDN18.2-positive Gastric Cancer | NCT01671774 | Entailment |
4,923 | 38 | A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago. It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amoun... | I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaki... | Inclusion Criteria:
- clinical diagnosis of parkinsonism and/or dystonia and/or tremor due to:
1. idiopatic parkinson's disease
2. atypical parkinsonism
3. sporadic or inherited/genetic dystonia
4. young-onset Parkinson's disease
... | Technology-based Analysis of Movement Disorders | NCT04591132 | Entailment |
3,031 | 22 | A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination. The boy is going to a school for students with learning disabilities. The patient was adopted, and his immunizations are up to date. Review of the patient's medical records is notable for c... | My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it co... | Inclusion Criteria:
- Molecular genetics diagnosis of the syndrome (number of CGG repeats in the FMR1 gene
over 200).
- Presenting characteristic symptoms of fragile X syndrome.
- Patients older than 6 years and younger that 19 years.
- Signed informed consen... | Safety and Efficacy Study of Antioxidants for the Treatment of the Fragile X Syndrome | NCT01329770 | Entailment |
5,777 | 43 | A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers. The rashes are mildly itchy. The patient has no other medical conditions and takes no medications. Vital signs are normal. On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and a... | I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been ... | Inclusion Criteria:
- 1. Histopathologically proven patients of OLP of all age groups complaining of symptoms
such as pain, burning sensitivity to hot and spicy food.
2. Who have signed informed consent.
Exclusion Criteria:
- 1. Patients who have taken any medication for OLP ... | Treatment Modalities of Oral Lichen Planus | NCT03237533 | Contradiction |
6,416 | 47 | A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks... | I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun.... | Inclusion Criteria:
1. Male or non-pregnant, non-lactating female, 18 years of age or older.
2. Signed informed consent form, which meets all criteria of current FDA regulations.
3. Females of child bearing potential must not be pregnant or lactating at Screening and
Random... | Randomized, Double-blind, Multiple-site, Placebo-controlled, Parallel-design Study in Patients With Moderate to Severe Facial Erythema Associated With Rosacea | NCT02289352 | Contradiction |
3,616 | 28 | A 23-year-old woman comes to the emergency department with a history of nosebleeds lasting for 1 hour. She has a history of heavy menses as well as occasional gum bleeding following dental procedures. Her mother also has a history of menorrhagia. Laboratory tests reveal increased bleeding time and slightly increased pa... | I had to rush to the ER because of a non-stop nosebleed that had been on for 1 hour. As a 23-year-old, I always had heavy periods, and sometimes, my gums would bleed after going to the dentist or brushing my teeth. I thought that it was not very alarming since my mom also had heavy periods. I did some lab tests that sh... | Inclusion Criteria:
- All patients above 18 years
- who are having blood taken for biochemical analysis when attending the ED
Exclusion Criteria:
- Acute medical patients that do not have blood drawn for routine biochemical testing.
- Pregnant
- Under... | Use of suPAR Algorithm for the ED Decision Making | NCT04402281 | Entailment |
5,815 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
- Episodes of heartburn (described as a burning feeling, rising from the stomach or
lower part of the chest up towards the neck) for 2 days or more during the last 7 days
prior to baseline.
- Confirmed Erosive Esophagitis within 1 week prior to start... | A Multicenter, Randomized, Double Blind, Double Dummy, Parallel-Group Efficacy Study Comparing 8 Weeks of Treatment With Esomeprazole Magnesium (40mg qd) to Lansoprazole (30mg qd) for the Healing of Erosive Esophagitis in Patients With Moderate or Severe Erosive Esophagitis | NCT00641602 | Contradiction |
1,225 | 6 | A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea. The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease. He smokes 2 packs of cigarettes daily for the past 30 years. On examination, there are decreased breath sounds and percussive d... | I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my ... | Inclusion Criteria:
1. Subject is at least 18 years of age.
2. Subject is cooperative and capable of following instructions.
3. Healthy subjects:
1. Never smokers.
2. No known history of respiratory, cardiovascular, hepatic, renal or metabolic
... | Measurement and Evaluation of Total Lung Capacity (TLC) in the Field of Pulmonary Functional Testing (PFT) | NCT01952431 | Entailment |
2,615 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
- hernia repair between 2006 and 2011
- laparoscopic hernia repair using intraperitoneal onlay-mesh (IPOM)
- patient agrees to be surveyed by phone
Exclusion Criteria:
- Patient rejects participation in survey
- patient already rej... | Recurrence and Patient Satisfaction After Laparoscopic Hernia Repair With Intraperitoneal Onlay-mesh (IPOM) | NCT01839942 | Contradiction |
466 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Women with poor response to ovarian stimulation. The definition of poor response was
based on the presence of at least one of the following criteria: Age > 40 years old,
day 2 FSH >9.5 mIU/ml, AMH < 2ng/ml ,at least one previous COH with less than 3
... | Administration of DHEA in Patients With Poor Response to Ovarian Stimulation for IVF | NCT02099916 | Contradiction |
2,242 | 14 | A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain. The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medicat... | I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopuri... | Inclusion Criteria:
1. Be at least 18 years of age;
2. Be able to provide informed consent
3. Be able to read and speak English
4. Have reliable Internet access and e-mail
5. Have a self-reported doctor diagnosis of arthritis, limited to the following
... | Web-based Support to Manage Arthritis Pain | NCT01463189 | Entailment |
3,881 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- Clinical diagnosis and radiological evidence of symptomatic osteoarthritis of the knee
- Moderate to severe pain
Exclusion Criteria:
- Other conditions in the knee, e.g., crystal arthropathies, septic necrosis, joint
replacement, major inju... | AP-007 Study to Evaluate Safety and Exploratory Efficacy of Three Intra-articular Injections of Ampion in the Knee of Adults With Pain Due to Osteoarthritis | NCT02184156 | Entailment |
1,318 | 7 | A 3-year-old girl is brought to the clinic by her parents for assessment of her short stature. Physical examination reveals short limbs and a relatively large head. She has a flat nasal bridge and a small midface. The girl's father exhibits similar physical features; however, her mother looks normal. The genetic testin... | I just brought my little 3-year-old girl to the clinic to have her checked up by the doctor. I was worried sick because she was smaller than her classmates. The lovely doctor performed a physical exam and she told me that she has short limbs and a larger head. My girl also has a flat nasal bridge and a small midface. M... | DISEASE CHARACTERISTICS:
- Histologically confirmed advanced, metastatic, recurrent, or unresectable soft tissue
sarcoma or gastrointestinal stromal tumor
- Measurable disease defined as lesions that can be measured in at least one dimension
as at least 20 mm with conve... | SU5416 in Treating Patients With Advanced, Metastatic, or Recurrent Soft Tissue Sarcomas | NCT00005862 | Contradiction |
6,087 | 45 | A 15-week-old infant brought to the clinic for the follow up. The infant has flat facies, small ears, a single palmar crease, and upward slanting eyes. He was born on 39th week to a 39-year-old woman who didn't have prenatal care. The medical record confirms the trisomy of chromosome 21 (Down syndrome). The infant is o... | My newborn, who is only 15 weeks old, had one of his follow-up appointments. The doctor pointed out that my baby had a flat face, small ears, only one palm line, and small eyes. He was born on his 39th week, while I was 39. What a coincidence! To be honest, I did not go to the doctor during my pregnancy. The doctor dia... | Inclusion Criteria:
1. Diagnosis of DS. This is the diagnosis that is being investigated
2. Speak English. This is the language spoken by the PI.
3. Medically stable, without physician- ordered restrictions. Some children with DS have
cardiac surgery or other complications ... | Investigating Trunk Control in Young Children With Down Syndrome | NCT03544840 | Contradiction |
1,840 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
1. Age from 18 to 80 years
2. Histology confirmed gastric adenocarcinoma (papillary, tubular, mucinous, signet ring
cell, or poorly differentiated) confirmed pathologically by endoscopic biopsy.
3. Clinical stage: cTNM: stage I or above at preoperative e... | The Effect of Immunological Heterogeneity of Tumor Microenvironment in the Prognosis of Gastric Cancer | NCT04819958 | Entailment |
515 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Histologically proven low-risk gestational trophoblastic neoplasia (persistent
hydatidiform mole or choriocarcinoma), defined as 1 of the following:
- Less than 10% decrease in the beta human chorionic gonadotropin (HCG) titer over
3 week... | Methotrexate Compared With Dactinomycin in Treating Patients With Gestational Trophoblastic Neoplasia | NCT00003702 | Contradiction |
1,822 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
- Any kind of malignancy
- Gastrointestinal bleeding in the last 48 hours
- Referred to emergency endoscopy
Exclusion Criteria:
- under 18 years old
- bleeding from non malignant lesions
- previous endoscopic treatment ... | Hemostatic Powder Versus Clinical Management for the Treatment of Upper Gastrointestinal Bleeding From Tumor Lesions | NCT02820077 | Entailment |
5,505 | 41 | A 61-year-old man comes to the emergency department complaining of an acute vision disturbance. He had an episode of vision disturbance in the right eye that occurred suddenly and resolved spontaneously in 15 minutes. He also has right jaw pain while chewing. He also complains of fatigue and hip muscle aches over the ... | I’m a 61-year-old man and I came to the ER because I had a sudden episode where I couldn’t see out of my right eye. It only lasted about 15 minutes and went away on its own but it really scared me. I’ve also been having pain in my right jaw when I chew. For the past few months I’ve felt really tired and noticed my hips... | Inclusion Criteria:
- Enrolled in the VCRC Contact Registry
- Patient reported diagnosis of Behçets disease, Churg-Strauss Syndrome, CNS Vasculitis,
Giant Cell Arteritis, granulomatosis with polyangiitis (Wegener's granulomatosis),
Henoch-Schöenlein Purpura, Microscopic... | Educational Needs of Patients With Systemic Vasculitis | NCT02190929 | Entailment |
3,658 | 29 | A 57-year-old man comes to the emergency department due to constipation. His last bowel movement was 2 days ago. He complains of spending about 30 minutes once attempting to defecate. He also has lower back pain. There is no history of trauma. The pain is not relieved with over-the-counter pain medications. His vita... | I'm a 57 year-old-man, and I had to go to the ER because I couldn't go defecate. My last trip to the toilet was 2 days ago, and I tried too many times, during 30 min, to get my poop to get out. I also have terrible lower back pain. The doctor did not notice any trauma. I tried to get the pain away using over-the-counte... | Inclusion Criteria:
- Adults more than 18 years of age and less than 65 years of age..
- Degenerative or isthmic spondylolithesis Grade 1,2 and 3.
- Recurrent Symptomatic recurrent lumbar disc prolapsed with or without evident neural
compression.
- Single lev... | Minimally Invasive Versus Open Transforaminal Lumbar Interbody Fusion | NCT03692845 | Contradiction |
5,172 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- Female: 50 years of age or older
- >5 years since last menses natural or surgical
- have lumbar spine BMD (bone mineral density) more that 2.5 standard deviations (SD)
below the young adult mean, or have 1-spine BMD more than 2.0 SD below the young ... | A Study of Monthly Risedronate for Osteoporosis | NCT00247273 | Entailment |
2,388 | 15 | An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity m... | I brought my 8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weak... | Inclusion Criteria:
- Dystophinopathy (Duchenne or severe Becker)
- >8yo
- with social insurance
- informed consent
Exclusion Criteria:
- arythmia
- impossibility to undergo an MRI (pacemaker, ....)
No condition on gender to be admitted to... | IRM Cardiaque en Respiration Libre Pour Des Patients Atteints de Dystrophinopathie sévère | NCT02078076 | Entailment |
6,447 | 47 | A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks... | I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun.... | Inclusion Criteria:
- Male or females at least 18 years of age;
- Women of childbearing potential must agree to use adequate contraception when sexually
active. Acceptable methods of contraception include, but are not limited to, (i)
condoms (male or female) with or wit... | 4 Week In-Use Study Evaluating How Well-Tolerated a Skin Care Product Is on Adults With Facial Redness | NCT03841032 | Entailment |
711 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
1. Subject is able to understand and sign the informed consent.
2. Subject is willing and able to comply with the protocol.
3. Male or female subjects of any race, aged 40 to 64 years
4. Subject has a BMI of 24 to 40 kg/m2
5. Subject has had pai... | Nutramax Joint Health Formulation Biochemical Response Study | NCT02614274 | Contradiction |
5,167 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
1. older than 50 years of age
2. high risk as defined from one of the following criteria: score≥1 on one minute
osteoporosis risk questionnaire; 10 year predicted fracture risk≥20% for major
osteoporotic fracture or ≥3% for hip fracture from FRAX; fall... | Osteoporosis and Fall Prevention and Posture Correction Interventions in the Metropolitan Area | NCT02803190 | Contradiction |
91 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion criteria:
bioavailable testosterone less than 103 nanogram/dl and DHEA-S level less than 157
microgram/dl for men; DHEA-S less than 95 microgram/dl for women;
Exclusion criteria:
significant ischemic heart disease, renal disease, uncontrolled hypertension, diabetes
m... | DHEA and Testosterone Replacement in Elderly | NCT00254371 | Contradiction |
1,430 | 9 | A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough. Her other medical problems include hypertension, dyslipidemia, and osteoarthritis. She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary ... | I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pr... | Inclusion Criteria:
1. Adult Tibetan, who have been living in the Tibetan Plateau since he/she was born.
2. Consistent with diagnosed hypertension, blood pressure, for 1-3 grade.
3. Aged 18-80 years old.
4. To sign informed consent.
Exclusion Criteria:
1. ... | Treatment of Hypertension in Tibetan Adult Population | NCT02217852 | Contradiction |
1,374 | 8 | A 7-month-old boy is brought to emergency by his parents due to irritability and inability to defecate for the past 3 days. The patient has had constipation and discomfort with bowel movements since birth. His symptoms worsened after eating semi-solid foods. Vital signs are normal. Abdominal examination shows diste... | My baby boy just turned 7 months old but my wife and I cannot get a hold of him! He has not been able to poop for 3 days! My poor little thing has been having constipation and bowel problems since birth. But since he ate some semi-solid food it has just been worse! The doctor said his vitals are normal but his belly is... | Inclusion Criteria:
- Confirmed histopathological diagnosis of Hirschsprung disease from January 1, 1990 to
August 31, 2019
- Long-segment Hirschsprung disease (type A and B)
- Total colonic aganglionosis (TCA)
- Surgery at CHUSJ
- Tissue blocks o... | The Association Between Calretinin and the Function of Ganglion Cells in Hirschsprung Disease | NCT04149093 | Contradiction |
2,667 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
- 18 years older
Exclusion Criteria:
- recurrent inguinal hernia
- previous low abdominal operation
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
| Preperitoneal Versus Pre-trasversalis Hernia Repair | NCT01350830 | Entailment |
6,305 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- Man above 18 years of age, of reproductive age, needing oncofertility preservation
through spermatozoa cryopreservation prior to a putative gonadotoxic treatment during
the COVID-19 pandemic.
- Symptomatic and asymptomatic COVID-19 patients. A pati... | Presence of SARS-CoV-2 in Semen: Impact on Fertility Preservation in Male Oncological Patients ? | NCT04487639 | Entailment |
2,372 | 15 | An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity m... | I brought my 8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weak... | Inclusion Criteria:
1. Diagnosis of DMD resulting from a nonsense mutation by whole genome sequencing of the
dystrophin gene
2. To have intact right or left biceps muscles, or an alternative muscle group that is
able to be underwent for appropriate evaluation of efficacy
... | Phase II Study of NPC-14 (Arbekacin Sulfate) to Explore Safety, Tolerability, and Efficacy in Duchenne Muscular Dystrophy | NCT01918384 | Entailment |
1,238 | 6 | A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea. The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease. He smokes 2 packs of cigarettes daily for the past 30 years. On examination, there are decreased breath sounds and percussive d... | I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my ... | Inclusion Criteria:
- age over 18 years
- presence of pleural effusion
- have undergone chest drain for fewer than 24 hours
Exclusion Criteria:
- contraindication to the use of non-invasive equipment that generates positive airway
pressure (such as: ... | Positive Airway Pressure on Pleural Effusion After Drainage | NCT02246946 | Entailment |
286 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- patients with history of three or more unsuccessful IVF-ET cycles with at least two
good quality embryos transferred and candidates for fresh embryo transfer
Exclusion Criteria:
Age less than 18 years or more than 35years and body mass index more than 30 ... | A RCT on the Effect of Platelets Rich Plasma in ICSI Patients With Recurrent Implantation Failure | NCT04434547 | Contradiction |
2,489 | 17 | A 67-year-old man comes to the clinic with slowly worsening vision in both eyes. He is not able to drive at night, as the symptoms are worse at night. His pupils are normal in diameter both in the light and darkness. Other medical history is unremarkable. Ocular examination shows loss of the red reflex and blurry vis... | I am a 67 years-old man, and I haven't been able to drive at night due to my vision getting worse. My vision is not the best in general, but night makes it even worse. The ophthalmologist told me that my pupils were normal. However, I have slow reflexes and blurry vision. My acuity test came back with 50/100 vision in ... | Inclusion Criteria:
- Snellen VA or equivalent ≤ 6/60 in both eyes
- Patient has capacity to give consent and to undertake vision tests
Exclusion Criteria:
- Diagnosis of functional vision loss
- Unwilling and/or unable to sign informed consent and complete the v... | Visual and Functional Assessment in Low Vision Patients | NCT01876147 | Entailment |
1,843 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
1. Consecutive patients with preoperative pathologically con-firmed gastric cancer by
endoscopy and preoperative imaging data (esophagography\CT\EUS\MRI) were included.
2. No contraindications for MRI examination. No contraindications contrast.
3. The pa... | Study of CT and MR in the Gastric Cancer | NCT04028375 | Entailment |
1,316 | 7 | A 3-year-old girl is brought to the clinic by her parents for assessment of her short stature. Physical examination reveals short limbs and a relatively large head. She has a flat nasal bridge and a small midface. The girl's father exhibits similar physical features; however, her mother looks normal. The genetic testin... | I just brought my little 3-year-old girl to the clinic to have her checked up by the doctor. I was worried sick because she was smaller than her classmates. The lovely doctor performed a physical exam and she told me that she has short limbs and a larger head. My girl also has a flat nasal bridge and a small midface. M... | DISEASE CHARACTERISTICS:
- Histologically confirmed squamous cell carcinoma of the head and neck
- Stage III, IVA, or IVB
- Must have completed cisplatin- or carboplatin-based chemoradiotherapy within the past
4-12 weeks
- Prior radiotherapy must ha... | Adjuvant Erlotinib After Completing Chemoradiotherapy in Locally Advanced Squamous Cell Carcinoma of the Head and Neck | NCT00079053 | Contradiction |
3,230 | 23 | A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn. The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness. She also reports occasional joint pain. Medical history... | I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to t... | Inclusion Criteria:
- diagnosis of pSS according to ACR/EULAR classification criteria
Exclusion Criteria:
- patient does not possess a smartphone with web connection
- patient unable to sign an informed consent
No condition on gender to be admitted to the trial.
No healthy s... | Eye Dryness Evaluation in Primary Sjögren's Syndrome | NCT03614299 | Entailment |
838 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- Adults over 18 years, there is no upper age limit.
- Osteoarthritis of the knee (defined as joint space narrowing and osteophytes in 1 or
more compartment) and moderate to severe knee pain (defined as 40-80mm on a 100mm
visual analogue scale).
... | Mindfulness for Osteoarthritis-related Knee Pain | NCT02595099 | Entailment |
4,418 | 34 | A 17-year-old male comes to the office due to several months of right elbow pain. The pain is worse with activity and limits his workouts and activities. He has tried over-the-counter medications with limited relief. Medical history is notable for eczema, and current medications include a topical hydrocortisone oint... | I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that... | Inclusion Criteria:
- Adult > 18 years of age
- Closed fracture
- Isolated injury
- No prior injury to ipsilateral forearm
- Less than or equal to two attempts at reduction
Exclusion Criteria:
- Ipsilateral upper extremity injury
... | Short Forearm Casting Versus Below-elbow Splinting for Acute Immobilization of Distal Radius Fractures | NCT02679066 | Contradiction |
569 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Symptomatic patients that were suspected as having intrauterine pathology such as
submucosal myoma, endometrial polyps or other endometrial pathological findings based
on the transvaginal ultrasound were enrolled.
- women who are more than 20 years... | Cervical Priming With Misoprostol Prior to Operative Hysteroscopy | NCT01024270 | Entailment |
4,557 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
- Patients diagnosed pathologically of Endometriosis or Adenomyosis among those who had
undergone laparoscopic surgery due to pelvic pain
- Patients who have been on GnRH agonist treatment for 6 months after being diagnosed
Endometriosis or Adenomyos... | Efficacy of Acupuncture on Chronic Pelvic Pain in Women With Endometriosis or Adenomyosis | NCT01259180 | Contradiction |
1,104 | 5 | A 23-year-old man comes to the emergency department following an episode of syncope. He was working out when he felt dizzy and passed out without head injury. He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has ... | I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special me... | Inclusion Criteria:
- Patients admitted to the emergency department for syncope as defined by European
Society of Cardiology (ESC) recommendations.
Exclusion Criteria:
- Patient under guardianship or safeguard of justice
- Refusal to participate
- In... | Hypersensitive Troponin Performance to Identify Syncope at Risk of Serious Adverse Events in the Short Term | NCT03528161 | Entailment |
3,163 | 23 | A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn. The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness. She also reports occasional joint pain. Medical history... | I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to t... | Inclusion Criteria:
1. Men or women aged 18 - 60 yrs old in generally good health.
2. Healthy oral cavity with no pre-existing oral diseases including cancer,
periodontitis, or mucositis.
3. No chewing or swallowing disorders.
4. No known clotting disorders.
... | Vitamin Gum Pharmacokinetics | NCT03230396 | Contradiction |
6,139 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- Diagnosis of COVID-19 based on either ground glass appearance in chest CT scan or
positive RT-PCR test for COVID-19
- Oxygen saturation drop below 93%
- Systolic blood pressure drop below 100 or blood pressure drop of 30 mm Hg from the
... | Evaluation of Therapeutic Effects of Melatonin by Inhibition of NLRP3 Inflammasome in COVID19 Patients | NCT04409522 | Contradiction |
3,479 | 25 | A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear. Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus. Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy s... | I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. ... | Inclusion criteria:
Male and female patients, 18-70 years of age.
Diagnosis of Type 2 diabetes treated with metformin and obesity (body mass index [BMI] >30
kg/m^2) and the following other abnormalities:
- Abdominal obesity (waist circumference >102 cm in men and >88 cm in women). ... | Effect of Lixisenatide on Postprandial Lipid Profile in Obese Type 2 Diabetic Patients | NCT02274740 | Entailment |
5,114 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- Older adults living independently;
- medical approval.
Exclusion Criteria:
- Non-smokers;
- Non-morbidly obese;
- No history of severe hypertension;
- No history of falls;
- No orthopaedic, neurological, p... | Study of the Long-term Effects of Exercise on Heath Indicators in Older People | NCT01874132 | Contradiction |
2,060 | 12 | A 47-year-old man comes to the office for routine checkup. He is complaining of chronic cough and occasional but progressive dyspnea. Other medical conditions include hypertension and osteoarthritis. The patient smokes a pack of cigarettes daily and does not use alcohol or illicit drugs. He used to be a construction... | I'm a 47-year-old former construction worker. I'm a man and I smoke a pack of cigs a day but I don't drink or do drugs. I went to my routine checkup because I've been coughing so much lately. I also had shortness of breath and it got worse over time. I already suffer from hypertension and osteoarthritis. My doctor foun... | Inclusion Criteria:
- IPF as diagnosed by chest CT or lung biopsy, and documented by a pulmonologist in the
patient's medical record
- Capacity to provide informed consent
Exclusion Criteria:
- Documented malignancy that would impact mortality within the study e... | Palliative Care and Quality of Life in Idiopathic Pulmonary Fibrosis | NCT03981406 | Contradiction |
4,471 | 34 | A 17-year-old male comes to the office due to several months of right elbow pain. The pain is worse with activity and limits his workouts and activities. He has tried over-the-counter medications with limited relief. Medical history is notable for eczema, and current medications include a topical hydrocortisone oint... | I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that... | Inclusion Criteria:
1. Clinical diagnosis of elbow pain not related by trauma.
2. Cases with self-reported history of overuse, infection, autoimmune disease, bleeding
tendency and neoplasm of bone, joint, soft tissue at elbow.
Exclusion Criteria:
1. Recent acute tr... | Role of MRI in Evaluation of Non-traumatic Causes of Painful Elbow | NCT03182127 | Entailment |
4,408 | 34 | A 17-year-old male comes to the office due to several months of right elbow pain. The pain is worse with activity and limits his workouts and activities. He has tried over-the-counter medications with limited relief. Medical history is notable for eczema, and current medications include a topical hydrocortisone oint... | I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that... | Inclusion Criteria:
- clinical diagnosis defined as pain over the lateral epicondyle provoked by palpation;
- A visual analogue scale (VAS) score for pain greater than 40mm;
- symptoms duration for more than 1 month.
Exclusion Criteria:
- other diseases that can ... | Mesotherapy In Lateral Epicondylitis | NCT04201249 | Contradiction |
2,234 | 14 | A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain. The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medicat... | I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopuri... | Inclusion Criteria:
1. Male or female 18 - 70 years of age
2. Previously met the preliminary criteria of ARA for the classification of the acute
arthritis of primary gout
3. Presenting with an acute attack (flare) of gout within 48 hours of pain onset and pain
... | Study Utilizing Rilonacept in Gout Exacerbations | NCT00855920 | Entailment |
5,405 | 40 | A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction. Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration. The patient has heavy menstrual cycles each month. She has no other medical problems and takes no medications... | I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical c... | Inclusion Criteria:
- Healthy female volunteers
- Age: 18 - 35 years (inclusive), smokers must not be older than 30 years at inclusion
- History of regular cyclic menstrual periods (with a cycle length between 25 and 35
days)
- Willingness to use barrier meth... | Cycle Control and Safety of E2-DRSP | NCT00653614 | Entailment |
5,449 | 40 | A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction. Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration. The patient has heavy menstrual cycles each month. She has no other medical problems and takes no medications... | I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical c... | Inclusion Criteria - Part A:
- Moderately severe (≤2% FVIII) hemophilia A
- <3 Years of age at the time of informed consent
- Caregiver (parent or legal guardian) has provided written informed consent
- ≤2 EDs to pdFVIII, rFVIII, or a single dose of FFP, Cryoprecipitate o... | Emicizumab PUPs and Nuwiq ITI Study | NCT04030052 | Entailment |
5,302 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria: patients who are postmenopausal women or men who aged older than 50
years and meet the indications for osteoporosis treatment according to the Thai
Osteoporosis Foundation's 2010 treatment guidelines.
- History of spinal or hip fractures with low energy trauma.
... | Efficacy and Safety of Brand Versus Generic Alendronate for Osteoporosis Treatment | NCT02371252 | Entailment |
1,560 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | Inclusion Criteria:
- Have a body mass index between 19.0 and 30.0 kilogram square meter (kg/m²), inclusive,
weight less than 125.0 kilogram (kg), and physical dimensions which appear small
enough to fit into the magnetic resonance imaging (MRI) and positron emission
t... | A Study of Nociceptin/Orphanin FQ Peptide Receptor Occupancy in Healthy Subjects | NCT01404091 | Contradiction |
4,018 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- 18 to 45 years.
- Unilateral symptomatic KOA.
- Patient in waitlist at the Schulthess Clinic for knee arthroplasty.
- Patient has mild to average pain levels
- Living place: Canton of Zurich or neighbouring Cantons.
- Signed w... | Somatosensory Stimulation in Knee Osteoarthritis | NCT02854176 | Entailment |
5,457 | 40 | A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction. Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration. The patient has heavy menstrual cycles each month. She has no other medical problems and takes no medications... | I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical c... | Inclusion Criteria:
- Systemically free as reported by the patients
- Minimum of 20 teeth present in the dentition (excluding wisdom teeth);
- Clinically healthy gingiva (on intact periodontium)
- Dental biofilm-induced gingivitis (plaque induced gingivitis) according to ... | Anticariogenic Effect of Moringa Oleifera Mouthwash Compared to Chlorhexidine Mouthwash | NCT04575948 | Entailment |
4,925 | 38 | A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago. It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amoun... | I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaki... | Inclusion Criteria:
- Age 18-45 years, inclusive, of both genders
- Negative pregnancy test for females who are not s/p hysterectomy with oophorectomy
- No history of episodic wheezing, chest tightness, or shortness of breath consistent
with asthma, or physician-diagnose... | Woodsmoke Particulate + Hypertonic Saline | NCT03851406 | Entailment |
3,810 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- Ages between 40 and 70 years, both gender
- Kellgren and Lawrence grades of I to III;
- The subjects volunteered participate in the study and complied with the regulations
and signed the written consent voluntarily.
- Meet the following ... | Multi-center Clinical Study of Guli Capsules in the Treatment of Knee Osteoarthritis | NCT02484508 | Entailment |
2,089 | 12 | A 47-year-old man comes to the office for routine checkup. He is complaining of chronic cough and occasional but progressive dyspnea. Other medical conditions include hypertension and osteoarthritis. The patient smokes a pack of cigarettes daily and does not use alcohol or illicit drugs. He used to be a construction... | I'm a 47-year-old former construction worker. I'm a man and I smoke a pack of cigs a day but I don't drink or do drugs. I went to my routine checkup because I've been coughing so much lately. I also had shortness of breath and it got worse over time. I already suffer from hypertension and osteoarthritis. My doctor foun... | Inclusion Criteria:
- All subjects/patients:
- Willing and able to complete the requirements of this study including the
signature of the written informed consent,
- Able to complete the study in 5 working days or less,
- Able to perform p... | Trial Comparing Effect of He/O2 to Medical Air on Pulmonary Function Disease | NCT00801307 | Entailment |
6,428 | 47 | A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks... | I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun.... | Inclusion Criteria:
- Healthy male or non-pregnant female ≥ 18 years-of-age with a clinical diagnosis of
moderate facial rosacea;
- Subjects had to have a definite clinical diagnosis of facial rosacea severity Grade 3
as per the IGE
Exclusion Criteria:
... | To Evaluate the Therapeutic Equivalence and Safety of Azelaic Acid 15% Topical Gel | NCT03094403 | Entailment |
4,267 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Key Inclusion Criteria:
- Written informed consent or assent
- Subject has completed study TR02-108, and has been compliant with the study protocol
- Women of childbearing potential must agree to use reliable methods of contraception
for the duration of the study
... | Extension Study of Liposomal Amikacin for Inhalation in Cystic Fibrosis (CF) Patients With Chronic Pseudomonas Aeruginosa (Pa) Infection | NCT01316276 | Entailment |
937 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- Presence of osteoarthritis of the knee. Traditional American College of Rheumatology
criteria, which are based on the presence of pain (gonalgia) plus at least three of
the following characteristics, will be used for the diagnosis of osteoarthritis of the
... | Effectiveness of Curcumin-based Food Supplement in Reducing Pain and Inflammatory Component in Osteoarthritis | NCT04207021 | Entailment |
5,351 | 40 | A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction. Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration. The patient has heavy menstrual cycles each month. She has no other medical problems and takes no medications... | I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical c... | Inclusion Criteria:
1. Menstruating females with menorrhagia or menometrorrhagia referred to hematology or
gynecology clinics at Texas Childrens Hospital. Menorrhagia is defined as regular
periods with heavy menstrual bleeding with a PBAC score greater than 100;
menomet... | Tranexamic Acid (TA) vs Combined Oral Contraceptive (COCP) Pilot Study | NCT01428713 | Contradiction |
2,796 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
- primary or recurrent inguinal hernia
Exclusion Criteria:
- previous major lower abdominal surgery, patient refusal of randomization, or unable to
accept general anesthesia
No condition on gender to be admitted to the trial.
No healthy subjects accepted... | Prospective Randomized Trial Comparing Three-port and Single-port TEP Repair in Adults | NCT01591395 | Entailment |
2,784 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
- Diagnosed primary or recurrence unilateral or bilateral inguinal hernia
- Age between 18 and 90;
Exclusion Criteria:
- Patients who prefer other surgical approach than TEP
No condition on gender to be admitted to the trial.
No healthy subjects accepted ... | Corona Mortis in Patients Undergoing TEP for Inguinal Hernia | NCT04303442 | Entailment |
3,060 | 22 | A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination. The boy is going to a school for students with learning disabilities. The patient was adopted, and his immunizations are up to date. Review of the patient's medical records is notable for c... | My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it co... | Inclusion Criteria:
- Age limit: 5 -50
- Primary diagnosis of mental retardation (IQ < 70)
- willingness to undergo Autologous Bone Marrow derived Mono Nuclear Stem Cell (BMMNCs)
transplantation.
- To give an informed consent as well as sign the required Info... | Safety and Efficacy of BMMNCin Patients With Mental Retardation | NCT01908400 | Entailment |
6,009 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
Patients aged > 18 years with severe GERD symptoms and esophagitis associated with short
esophagus
Exclusion Criteria:
Patients aged < 18 years Patients aged > 18 years with sliding hiatal hernia
No condition on gender to be admitted to the trial.
No healthy subjec... | Minimally Invasive Collis-Nissen for the Treatment of Short Esophagus | NCT02288988 | Entailment |
4,769 | 36 | A 47-year-old woman comes to the clinic complaining of dizziness. She also has occasional nausea and ringing in her right ear. The patient also has difficulty hearing while holding her phone to the left ear, although hearing in her right ear is normal. The dizziness improves spontaneously, and she feels fine between... | The other day, I had to go to the clinic due to severe dizziness. I'm 47 years old, and I've been suffering from nausea and ringing in my right ear. I also have difficulty hearing in my left ear while I hold my phone, even if my hearing in my right ear is normal. The dizziness just gets me all of a sudden but I don't h... | Inclusion Criteria:
- Patients with unilateral Ménière's disease (definite or probable, according to
Committee on Hearing and Equilibrium guidelines, 1995) with hearing loss and
presenting with recurrent vertigo, not responding to medical treatment for at least 6
month... | Transtympanic Gentamicin vs. Steroids in Refractory Meniere's Disease | NCT00802529 | Entailment |
398 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Women with clomiphene citrate failure (defined as at least previous 3 ovulatory cycles
with clomiphene citrate, with no pregnancy),
- persistently thin endometrium (less than 7 millimeters in at least 3 cycles).
- normal baseline Follicle Stimulatin... | Autologous Platelet-rich Plasma for Clomiphene Citrate-induced Thin Endometrium | NCT03770026 | Contradiction |
5,497 | 41 | A 61-year-old man comes to the emergency department complaining of an acute vision disturbance. He had an episode of vision disturbance in the right eye that occurred suddenly and resolved spontaneously in 15 minutes. He also has right jaw pain while chewing. He also complains of fatigue and hip muscle aches over the ... | I’m a 61-year-old man and I came to the ER because I had a sudden episode where I couldn’t see out of my right eye. It only lasted about 15 minutes and went away on its own but it really scared me. I’ve also been having pain in my right jaw when I chew. For the past few months I’ve felt really tired and noticed my hips... | Inclusion Criteria:
- Written consent
- Affiliation to a social security system
- Diagnosis of GCA, as defined by the revised GCA diagnosis criteria:44
- Age ≥50 years at disease onset
- AND History of erythrocyte sedimentation rate (ESR) ≥50 mm/h OR... | MEthotrexate Versus TOcilizumab for Treatment of GIant Cell Arteritis: a Multicenter, Randomized, Controlled Trial | NCT03892785 | Entailment |
669 | 3 | A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug. Blood pressure is 120/80 mm Hg and pulse is 70/min. Oxygen saturation is 99% on room air. BMI is 24 kg/m2. Skin examination shows increased pigmentation.... | I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI i... | Inclusion Criteria:
- Willing and able to give informed consent for participation in the study
- Men and women aged 18 years or older and generally in good health
- For iron-deficient volunteers: ferritin ≤ 15 microg/L and transferrin saturation < 16%
- For iron-replete v... | Iron Status and Human Metabolism | NCT02308449 | Contradiction |
5,508 | 41 | A 61-year-old man comes to the emergency department complaining of an acute vision disturbance. He had an episode of vision disturbance in the right eye that occurred suddenly and resolved spontaneously in 15 minutes. He also has right jaw pain while chewing. He also complains of fatigue and hip muscle aches over the ... | I’m a 61-year-old man and I came to the ER because I had a sudden episode where I couldn’t see out of my right eye. It only lasted about 15 minutes and went away on its own but it really scared me. I’ve also been having pain in my right jaw when I chew. For the past few months I’ve felt really tired and noticed my hips... | Inclusion Criteria:
1. 18 years of age or over
2. A clinical suspicion of a new diagnosis of GCA e.g. patients with a new onset of
headache, scalp tenderness, with or without elevated CRP or ESR, jaw or tongue
claudication with or without visual loss
3. Partici... | Aetiology of TemporaL Arteritis Study | NCT02584517 | Entailment |
1,313 | 7 | A 3-year-old girl is brought to the clinic by her parents for assessment of her short stature. Physical examination reveals short limbs and a relatively large head. She has a flat nasal bridge and a small midface. The girl's father exhibits similar physical features; however, her mother looks normal. The genetic testin... | I just brought my little 3-year-old girl to the clinic to have her checked up by the doctor. I was worried sick because she was smaller than her classmates. The lovely doctor performed a physical exam and she told me that she has short limbs and a larger head. My girl also has a flat nasal bridge and a small midface. M... | Inclusion Criteria:
1. Individuals with a documented diagnosis of achondroplasia based on:
1. Genetic confirmation of achondroplasia and/or
2. Clinical diagnosis of achondroplasia (clinical examination or radiological
assessment)
2. ≥ five years of... | Lifetime Impact of Achondroplasia Study in Europe-LIAISE | NCT03449368 | Contradiction |
4,566 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
- Healthy women, inclusive of ages 18-35* years at the enrollment visit
- Intact uterus and both ovaries
- Prior history of regular menstrual cycles that usually occur every 28 ± 7 days when
not using hormonal contraception; if postpartum or post-abor... | An Open-label Study to Evaluate the Effects of Concurrent Administration of Vaginal Antimycotic Medication Miconazole Nitrate on the Pharmacokinetics of Nestorone and Ethinyl Estradiol Delivered by a Contraceptive Vaginal Ring in Normal Ovulating Women | NCT02215395 | Contradiction |
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