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Clinical and instrumental evaluation of sensory function before and after percutaneous anterolateral cordotomy at cervical level in man. Sensory perception thresholds were assessed by clinical testing and by quantitative instrumental testing before and after operation in 16 subjects for whom unilateral percutaneous cer...
general pathological conditions
Regulation of fibrillar collagen types I and III and basement membrane type IV collagen gene expression in pressure overloaded rat myocardium. Left ventricular hypertrophy is based on cardiac myocyte growth. The hypertrophic process can be considered heterogeneous based on whether it also includes a remodeling and accu...
cardiovascular diseases
Identification of pre- and postcentral gyri on CT and MR images on the basis of the medullary pattern of cerebral white matter. The authors illustrate a new method to identify the pre- and postcentral gyri on computed tomographic (CT) and magnetic resonance (MR) images of the brain on the basis of the pattern of the me...
neoplasms
Long-term effects of delapril on renal function and urinary excretion of kallikrein, prostaglandin E2, and thromboxane B2 in hypertensive patients. The effects of delapril, an angiotensin converting enzyme (ACE) inhibitor, on renal function and the renin-angiotensin and kallikrein-prostaglandin systems were investigate...
cardiovascular diseases
Emergency surgical treatment for nonvariceal bleeding of the upper part of the gastrointestinal tract. Endoscopic and biochemical data were collected prospectively from 1,530 patients admitted with nonvariceal bleeding of the upper part of the gastrointestinal tract between September 1985 and June 1989. Therapeutic end...
general pathological conditions
Do we need another antihypertensive agent? The factors to be considered in selecting antihypertensive agents have traditionally centered around balancing efficacy against adverse side effects. The former can be achieved by a variety of agents alone or in combination. The latter not only involves safety but is also conc...
cardiovascular diseases
Immunohistologic evaluation of parathyroid hormone-related protein in human lung cancer and normal tissue with newly developed monoclonal antibody. With a newly developed monoclonal anti-PTHrP antibody, 4B3, the immunohistochemical localization of the parathyroid hormone-related protein (PTHrP) was studied on the forma...
neoplasms
Development and prospective application of quantitative 2-day stress-rest Tc-99m methoxy isobutyl isonitrile SPECT for the diagnosis of coronary artery disease. The clinical diagnostic accuracy of 2-day stress/rest quantitative Technetium-99m (Tc-99m) methoxy-isobutyl-isonitrile (Tc-sestamibi) single photon emission co...
cardiovascular diseases
Congestive heart failure, coronary events and atherothrombotic brain infarction in elderly blacks and whites with systemic hypertension and with and without echocardiographic and electrocardiographic evidence of left ventricular hypertrophy. Hypertension was present in 50% of 196 blacks and in 36% of 382 whites (p less...
cardiovascular diseases
Noninvasive detection of occlusive disease of the carotid siphon and middle cerebral artery. Recently, transcranial Doppler sonography has been introduced into clinical practice for noninvasive investigation of the large intracranial arteries. To determine its accuracy for detection of stenosing or occluding lesions, 1...
cardiovascular diseases
Endoscopic ethmoidectomy and maxillary antrostomy in immunodeficient patients. The efficacy of endoscopic sinus surgery was evaluated in 11 patients with diverse types of primary immunodeficiency disease and symptoms of chronic sinusitis. The postoperative symptoms and ability to eliminate antibiotics were used as outc...
general pathological conditions
Reappraisal of surgical treatment of traumatic transection of the thoracic aorta. Since Crawford's report in 1973, repair of traumatic transection of the thoracic aorta without shunt or bypass has emerged as a popular technique which simplifies the operation and avoids use of heparin. Growing evidence, however, indicat...
nervous system diseases
Mental activity, adrenergic modulation, and cardiac arrhythmias in patients with heart disease. All of the electrophysiological mechanisms of arrhythmias are sensitive to the influences of the autonomic nervous system, particularly to its adrenergic limb. Arrhythmogenic areas may also be dependent on the inhomogeneity ...
general pathological conditions
Screening for hypercholesterolemia among Canadians: how much will it cost? [published erratum appears in Can Med Assoc J 1991 Mar 1;144(5):545] OBJECTIVE: To determine the cost of screening all Canadians aged 30 years or more without coronary heart disease (CHD) for hypercholesterolemia. DATA SOURCES: The expected resu...
cardiovascular diseases
Pulmonary disease following intravesical BCG treatment. Bacillus Calmette-Guerin (BCG) is an attenuated strain of Mycobacterium bovis that has been used in the treatment of malignant disease for over 20 years and for the treatment of bladder cancer since 1976. Major complications of this treatment are infrequent. We re...
neoplasms
Cisplatin, continuous-infusion 5-fluorouracil, and intermediate-dose methotrexate in the treatment of unresectable non-small cell carcinoma of the lung. Forty-one patients with unresectable non-small cell carcinoma of the lung (NSCCL) were treated with cisplatin 20 mg/m2/d for 5 days as a daily bolus injection, 5-fluor...
neoplasms
Symptomatic and essential rhythmic palatal myoclonus. Rhythmic palatal myoclonus (RPM) is a rare movement disorder consisting of continuous synchronous jerks of the soft palate, muscles innervated by other cranial nerves and, rarely, trunk and limb muscles. It usually develops secondary to brainstem or cerebellar disea...
general pathological conditions
Plasma fibrinogen and coronary risk factors: the Scottish Heart Health Study. Plasma fibrinogen was measured in a sample of 8824 men and women aged 40-59 years participating in the Scottish Heart Health Study, and related to cardiovascular risk factors. Women had higher fibrinogen levels than men. In both sexes, multiv...
cardiovascular diseases
Protective effect of a novel calcium blocker, S-312-d, on ischemic acute renal failure in rat. The effect of the calcium blocker S-(+)-methyl 4,7-dihydro-3-isobutyl-6-methyl-4-(3-nitro-phenyl)thieno[2,3-b]pyridine- 5-carboxylate (S-312-d) on ischemic acute renal failure (ARF) was studied in rats. Ischemic ARF was induc...
cardiovascular diseases
Non-drug related asystole associated with anaesthetic induction. A patient is presented where routine venepuncture associated with anaesthetic induction resulted in bradycardia and asystole. The case highlights the need for special caution with, and ECG monitoring throughout induction for, patients with a history of sy...
cardiovascular diseases
Psychological characteristics of children with Shwachman syndrome. Twelve children and young adults with Shwachman syndrome were compared with their unaffected siblings and with controls suffering from cystic fibrosis in terms of intellectual ability, motor skills, and behaviour. There were highly significant differenc...
digestive system diseases
The lovastatin-treated rodent: a new model of barrier disruption and epidermal hyperplasia. Recent studies have linked epidermal cholesterol synthesis with maintenance of the permeability barrier. To assess directly the importance of cholesterol synthesis, we applied lovastatin, a potent inhibitor of cholesterol synthe...
general pathological conditions
Progression of native coronary artery disease at 10 years: insights from a randomized study of medical versus surgical therapy for angina. Repeat coronary angiography was performed in 42 patients 10 years after randomization to medical (n = 21) or surgical (n = 21) therapy for chronic angina. The native coronary arteri...
general pathological conditions
Human papillomavirus type 1-associated squamous cell carcinoma in a heart transplant recipient. The occurrence of squamous cell carcinomas in organ transplant recipients with warts represents a good model to study viral carcinogenesis. Most of the cases were reported in renal transplant recipients. We present the case ...
neoplasms
The risk of developing subsequent nonmelanoma skin cancers. Data from the Southeast Arizona Skin Cancer Registry collected during 1985 through June 1988 were used in this study. Patients who had a nonmelanoma skin cancer (basal cell or squamous cell carcinoma) removed in 1985 were observed until subsequent nonmelanoma ...
neoplasms
The distribution of muscle weakness in upper motoneuron lesions affecting the lower limb. To determine the distribution of weakness in the lower limb after upper motoneuron lesions the strength of 8 muscle groups was measured. Four groups of patients were studied: 22 control subjects, 16 patients with unilateral leg pa...
general pathological conditions
Febrile status epilepticus As part of a study of status epilepticus in children (Maytal J, Shinnar S, Moshe SL, Alvarez LA. Pediatrics. 1989; 83:323-331); 44 children with febrile convulsions lasting more than 30 minutes were followed for a mean of 28 months (range 4 to 72). Thirty children were followed prospectively....
nervous system diseases
Drop attacks with Meniere's syndrome. We report the clinical features of 12 patients with drop attacks associated with Meniere's syndrome. Each described a sensation of being pushed, thrown, or knocked to the ground or a sudden illusion of movement of the environment that led to a fall. These episodes were not accompan...
general pathological conditions
The addition of doxazosin to the treatment regimen of patients with hypertension not adequately controlled by beta-blockers. When doxazosin was given to patients with hypertension not adequately controlled by beta-blockade, blood pressure was normalized in 94% of the 34 patients (blood pressure less than or equal to 14...
cardiovascular diseases
trans-Activation of genes encoding activation-associated human T lymphocyte surface proteins by murine retroviral sequences. The mechanisms whereby RNA leukemia viruses cause T lymphocyte leukemias or lymphomas after a long latent period are not understood. We report here that infection of human T lymphocyte lines with...
neoplasms
Persistent hepatitis B virus following interferon alfa therapy and liver transplantation. A 44-year-old man with chronic hepatitis B virus infection and cirrhosis was treated with recombinant human interferon alfa for 67 days immediately before orthotopic liver transplantation and immunoprophylaxis with hyperimmune glo...
general pathological conditions
Outpatient management of schizophrenia. As effective antipsychotic pharmacotherapy has become available, patients with schizophrenia are increasingly managed in an outpatient setting by primary care physicians. Pharmacotherapy is generally effective in treating "positive," or psychotic, symptoms and lessening the risks...
cardiovascular diseases
Prognostic factors in acute renal failure following aortic aneurysm surgery. This study analyses the prognostic factors associated with survival in 70 patients who developed acute renal failure following surgery for an aortic aneurysm. Forty-nine patients (70 per cent) had surgery for a ruptured aortic aneurysm and 21 ...
general pathological conditions
Pinch modification used to repair a large surgical defect on the scalp: other proposed uses. Dr Peng's "pinch modification" of the linear advancement flap, a reconstructive technique used to correct surgical wounds on the nose and suggested as a surgical alternative in other non-hair-bearing skin, was used successfully...
neoplasms
Impact of maternal HIV infection on obstetrical and early neonatal outcome. In a case-control study of 177 HIV-seropositive and 326 seronegative women and their newborns in Nairobi, Kenya, maternal HIV infection at term was independently associated with travel to other African countries [odds ratio (OR) 4.9, P less tha...
general pathological conditions
Interventricular coronary steal induced by stenosis of left anterior descending coronary artery in exercising pigs. BACKGROUND. In pigs and humans, the left anterior descending coronary artery (LAD) supplies the left ventricular anterior wall (LVAW), anterior septum, and paraseptal band of the right ventricular anterio...
cardiovascular diseases
Reoperation versus alternatives in retained biliary calculi. Retained common bile duct stones can be treated by operation, dissolution, extraction, fragmentation, papillotomy, and reoperation. Each approach requires some expertise, and the likelihood of success of most depends on the composition and size of the stones....
digestive system diseases
Combined gadolinium-enhanced and fat-saturation MR imaging of renal masses. Combined gadopentetate dimeglumine enhancement and fat-saturation (FS) spin-echo (SE) magnetic resonance (MR) imaging for the detection and characterization of renal masses was evaluated in 43 patients with a total of 71 lesions (28 solid masse...
neoplasms
Oral labetalol in hypertensive urgencies. The response to incremental doses of oral labetalol in 16 patients with hypertensive urgencies is presented. After inadequate blood pressure control with 20 mg of intravenous furosemide, each patient received a 300 mg oral dose of labetalol. Subsequent oral doses of labetalol, ...
cardiovascular diseases
Epidemiology of heart failure. Analysis of 34 years of follow-up of Framingham Study data provides clinically relevant insights into the prevalence, incidence, secular trends, prognosis, and modifiable risk factors for the occurrence of heart failure in a general population sample. Heart failure was found to be highly ...
cardiovascular diseases
Protective effect of increased glycolytic substrate against systolic and diastolic dysfunction and increased coronary resistance from prolonged global underperfusion and reperfusion in isolated rabbit hearts perfused with erythrocyte suspensions. Current therapy of myocardial infarction may include early reperfusion. W...
cardiovascular diseases
Traumatic rupture of the thoracic aorta presenting as transient paraplegia. A patient involved in a high-speed motor vehicle accident presented paraplegic to the emergency department. He was noted to have an abnormal chest x-ray and, subsequently, underwent aortography which revealed aortic transection. The patient's p...
cardiovascular diseases
Prognostic determinants in extracorporeal membrane oxygenation for respiratory failure in newborns. Extracorporeal membrane oxygenation (ECMO) is becoming an accepted therapeutic modality for newborn respiratory failure, but there is little information available regarding the prognostic determinants with this technique...
digestive system diseases
Spirochetal infection of the central nervous system. Four spirochetal diseases frequently involve the central nervous system: syphilis, leptospirosis, relapsing fever, and Lyme borreliosis. In particular, syphilis and Lyme borreliosis are increasing problems. During the spirochetemic phase there is seeding of the nervo...
nervous system diseases
Induction, blockade and restoration of a persistent hypersensitive state. A new model of chronic hypersensitivity was developed in the rat by daily intraplantar administration of either prostaglandin E2 dopamine or isoprenaline, for a period of 2 weeks. Like other hyperalgesic mediators, dibutyryl-cAMP, when applied to...
general pathological conditions
Abdominal wall considerations and complications in reoperative surgery. The abdominal wall is the source of significant problems for patients undergoing multiple abdominal operations. The orientation of sequential incisions must be carefully considered to avoid compromise of the abdominal wall blood supply, which may r...
general pathological conditions
A case of lisinopril-induced lithium toxicity We describe a patient who developed lithium toxicity when lisinopril was substituted for clonidine. Possible mechanisms of angiotensin-converting enzyme (ACE) inhibitor-induced lithium toxicity are discussed. Aggressive serum lithium concentration monitoring and a reduction...
cardiovascular diseases
Non-ossicle homograft bone prostheses in the middle ear. This thesis proposes the use of human cadaver non-ossicle temporal homograft bone as middle ear reconstructive material. Bone obtained from the otic capsule histologically resembles that of the ossicles more so than any other bone in the body. The otic capsule, d...
general pathological conditions
Cyclosporine enhances the growth of carcinogen-induced enzyme-altered foci in rat liver. Cyclosporine, a powerful immunosuppressant, has been used successfully for organ transplantation. Its efficacy on liver transplants of patients with primary hepatic tumors remains controversial because of a high rate of recurrence ...
neoplasms
CT diagnosis of acquired small bowel volvulus. Small-bowel volvulus is an uncommon but important cause of small-bowel obstruction and often results in ischemia or infarction. Clinical examination and plain film radiography may be nondiagnostic, leading to delay in surgical intervention with subsequent increase in morbi...
digestive system diseases
Alternation of gastric mucosal glycoprotein (lectin-binding pattern) in gastric mucosa in stress. A light and electron microscopic study. Gastric mucosal cells of the rat glandular stomach were studied by light and electron microscopic procedures by use of lectins in the development of acute gastric mucosal lesions. Ef...
general pathological conditions
Synthesis of IL-1 alpha and IL-1 beta by arterial cells in atherosclerosis. Interleukin-1 (IL-1) has been implicated as a regulatory protein in the development and clinical sequelae of atherosclerosis. To determine which cells in the atherosclerotic plaque synthesize IL-1 in situ, the authors evaluated histologic secti...
cardiovascular diseases
Early gastric cancer. Twenty-eight-year experience. A retrospective study of early gastric cancer (60 patients) was performed to evaluate its diagnosis and treatment. Ninety-five per cent of patients presented with nonspecific gastrointestinal symptoms and 53.3% had been treated for presumed benign disease for up to 48...
general pathological conditions
Enteroliths causing intermittent obstruction in a patient with Crohn's disease. Calcified enteroliths as a cause of intermittent small bowel obstruction is an uncommon clinical entity. The pathophysiological mechanism involves stasis of intestinal contents and has been associated with Meckel's diverticulum, tuberculosi...
digestive system diseases
Pulmonary malignant angioendotheliomatosis. Presentation with fever and syndrome of inappropriate antidiuretic hormone. A 64-year-old man presented with protracted fever, hyponatremia, and mononeuritis multiplex. Inappropriate antidiuretic hormone secretion was established. The absence of pulmonary infiltrates preclude...
neoplasms
Significance of fill-in after thallium-201 reinjection following delayed imaging: comparison with regional wall motion and angiographic findings To identify reversible defects, reinjection of a small amount of thallium-201 (201Tl) following 3-hr delayed imaging was performed in 60 patients with coronary artery disease ...
cardiovascular diseases
Attributes and survival patterns of multiple primary cutaneous malignant melanoma. From a series of 1495 patients with primary cutaneous malignant melanoma (PCMM), 26 patients (1.73%) had multiple primary cutaneous malignant melanoma (MPCMM). This report describes the attributes and survival patterns in this small, but...
neoplasms
Tongue ischemia from a soft-drink can: report of case. A young girl was brought to the emergency department because her tongue became entrapped while she was drinking from an aluminum soft-drink can. A dental drill was used to remove the can. The tongue was observed for 48 hours, during which an ischemic area recovered...
general pathological conditions
Acute bronchitis: general practitioners' views regarding diagnosis and treatment. A survey was conducted among 800 Dutch general practitioners to establish their views on the diagnosis and treatment of bronchitis and related disorders with reference to 12 theoretical patients. The answers of the 467 respondents (respon...
general pathological conditions
Bronchodilator responses to anticholinergic and beta-adrenergic agents in acute and stable COPD Patients with COPD may respond differently to anticholinergic and beta-agonist bronchodilators. Previously, in acutely ill COPD patients, we showed similar improvements in pulmonary function after each drug (study 1). The re...
general pathological conditions
Growth hormone inhibits tumor metastasis. The effect of growth hormone on tumor growth and metabolism in the tumor-bearing host is unknown. This study was done to determine the effect of recombinant growth hormone on primary tumor growth, tumor metastasis, and carcass weight in tumor-bearing animals. Twenty-seven femal...
general pathological conditions
Endoscopic retrograde cholangiopancreatography in infantile cholestasis. The difficulty of distinguishing surgically correctable causes of conjugated hyperbilirubinaemia in infants from other causes means that some infants may undergo laparotomy and intraoperative cholangiography unnecessarily, and others may be referr...
general pathological conditions
Approach to the patient with genital ulcer disease. The three major diseases characterized by genital ulcers--genital herpes, syphilis, and chancroid--are common, with genital herpes being most common in industrialized countries and chancroid being most common in developing countries. One fourth to one half of patients...
general pathological conditions
Intracranial pressure in African children with cerebral malaria Opening lumbar cerebrospinal fluid (CSF) pressure was measured with a paediatric spinal fluid manometer in 26 of 61 Kenyan children (mean age 39 months) with cerebral malaria. In all cases pressure was above normal (mean [SD]22.6 [7.4] cm CSF, range 10.5-3...
general pathological conditions
Pulmonary hypertension five years after left pneumonectomy for adenoid cystic carcinoma. We report the findings in a patient with shortness of breath due to pulmonary hypertension five years after left pneumonectomy. Mediastinal recurrence of an incompletely resected and slowly growing adenoid cystic carcinoma of the l...
cardiovascular diseases
Prostate cancer: transrectal ultrasound and pathology comparison. A preliminary study of outer gland (peripheral and central zones) and inner gland (transition zone) cancer. A study was conducted to compare results of transrectal ultrasound with pathologic findings on 116 patients who underwent radical prostatectomy fo...
general pathological conditions
Studies of myocardial protection in the immature heart. I. Enhanced tolerance of immature versus adult myocardium to global ischemia with reference to metabolic differences. This study compares the metabolism and functional responses of adult and immature hearts to a standard ischemic insult. Ten adult dogs (25 to 27 k...
cardiovascular diseases
Kupffer cell activation and endothelial cell damage after storage of rat livers: effects of reperfusion. Reperfusion injury characterized by loss of endothelial cell viability occurs after cold ischemic storage of livers for transplantation surgery. Here, ultrastructural changes in stored rat livers were examined by sc...
general pathological conditions
Role of angioplasty in myocardial infarction management strategies: a review. The role of angioplasty in acute myocardial infarction has been extensively studied in the past few years. Although angioplasty in some circumstances can be the primary reperfusion intervention, logistic problems and the excellent results of ...
cardiovascular diseases
Late volume changes in retrosternal colon bypass. Esophageal obstruction by malignancy, chemical burns, or other less common entities presents a challenge for the surgeon. Either for esophageal substitution after esophageal resection or as a bypass for the obstructed esophagus, colon interposition is often the best ava...
digestive system diseases
Insulin-like growth factor II-mediated proliferation of human neuroblastoma. Neuroblastoma is an embryonal tumor that typically arises in cells of the developing adrenal medulla. IGF-II mRNA is expressed at high levels in the adrenal cortex before birth but it is not detectable until after birth in the adrenal medulla....
neoplasms
The role of cellular maturation in neutrophil heterogeneity. Previous studies have shown that many neutrophil (PMN) characteristics are heterogeneous but the origin of PMN heterogeneity is unknown. It is unclear if PMN functional heterogeneity is secondary to maturational differences or due to distinct subpopulations o...
neoplasms
Radiculomegaly of canines and congenital cataracts--a syndrome? Radiculomegaly of single teeth is very uncommon. Our survey indicates that the canine tooth is most frequently affected. Although illustrated in a number of texts of dental anatomy, there is a lack of detailed case reports.
general pathological conditions
Vascular responsiveness in obstructed gut. Multiorgan system failure due to hypotension and sepsis is an important cause of death in patients with bowel obstruction. We have investigated the pathophysiology of this entity in an animal model. After 5 days of bowel obstruction, blood flow in the superior mesenteric arter...
digestive system diseases
Plasticity in the aging brain. Reversibility of anatomic, metabolic, and cognitive deficits in normal-pressure hydrocephalus following shunt surgery. The course of idiopathic normal-pressure hydrocephalus was studied in a 78-year-old woman with a 4-year history of progressive dementia who underwent neuropsychologic tes...
nervous system diseases
Pseudospasticity in Guillain-Barre syndrome. We report a woman with Guillain-Barre syndrome who developed a flexion posture of the right arm and hand resembling upper motor neuron dysfunction. EMG demonstrated that involuntary peripherally generated continuous motor unit discharges caused the posture.
nervous system diseases
Prevalence and association of asteroid hyalosis with systemic diseases. We performed a cross-sectional study of 12,205 patients, which identified 101 patients (0.83%) with asteroid hyalosis. These patients were examined for associated systemic and ocular conditions. Diabetes mellitus was found in 29 of the patients wit...
cardiovascular diseases
The long-term effects of radiation therapy on patients with ovarian dysgerminoma. A retrospective chart review and questionnaire study was undertaken to look at the long-term effects of radiation therapy in ovarian dysgerminoma patients. Forty-three patients and 55 controls responded to a questionnaire that detailed bo...
digestive system diseases
Immunolocation of TNF-alpha/cachectin in human melanoma cells: studies on co-cultivated malignant melanoma. We have investigated the ability of metastatic cells to produce the macrophage cytokine, TNF-alpha/cachectin, as these cells have macrophage-like properties such as infiltration and migration. We looked for TNF-a...
neoplasms
AAEM minimonograph #35: Clinical experience with transcranial magnetic stimulation. We elicited motor evoked potentials (MEPs) using transcortical magnetic stimulation in 150 control subjects aged 14 to 85 years and 275 patients with a variety of diseases. There were no significant side effects. Cortex-to-target muscle...
nervous system diseases
Contributions of the Zollinger-Ellison syndrome. The salient contributions of the Zollinger-Ellison syndrome have made it unique. No pancreatic endocrine tumor described before (insulinoma) or subsequently (glucagonoma, somatostatinoma, vipoma, pancreatic-polypeptidoma) has been the topic of such a variety of studies, ...
neoplasms
Vitamin E in gastric mucosal injury induced by ischemia-reperfusion. To clarify the relationship among vitamin E, oxygen radicals, and lipid peroxidation in ischemia-reperfusion, we produced an experimental model of gastric mucosal injury in rats by ischemia-reperfusion with clamping of the celiac artery and measuremen...
general pathological conditions
Prostate specific antigen for assessing response to ketoconazole and prednisone in patients with hormone refractory metastatic prostate cancer. Serial prostate specific antigen levels were assessed in 15 patients with hormone refractory metastatic prostate cancer treated with ketoconazole and prednisone. Of the men 12 ...
neoplasms
Assessment of fibrin(ogen) degradation products in preeclampsia using immunoblot, enzyme-linked immunosorbent assay, and latex-based agglutination. Plasma and serum from pregnant women with preeclampsia (N = 35) and normotensive pregnant (N = 71) and nonpregnant (N = 10) controls were screened for fibrin(ogen) degradat...
general pathological conditions
Antibodies in anti-HBe-positive patient sera bind to an HBe protein expressed on the cell surface of human hepatoma cells: implications for virus clearance. The relevance of the recently described membrane-bound form of the HBe protein for the antiviral immune response was examined. The data show that antibodies in ant...
digestive system diseases
Congenital tracheoesophageal fistula associated with carcinoma of the lung in an adult. A rare case of adult congenital H-type tracheoesophageal fistula was diagnosed. Subsequently, at operation, large cell, undifferentiated carcinoma of the right middle lobe with extension to the right lobe and adherence to the diaphr...
neoplasms
Doppler echocardiographic evaluation of pulmonary artery flow after modified Fontan operation: importance of atrial contraction. Doppler echocardiography was used to evaluate blood flow in the pulmonary artery in 14 patients 2 to 42 months (mean (SD) 17 (12) months) after a modified Fontan operation incorporating a dir...
cardiovascular diseases
Inotropic response to norepinephrine is augmented early and maintained late in conscious dogs with perinephritic hypertension. We studied the inotropic responses to intravenous infusions of norepinephrine in nine conscious chronically instrumented dogs before and early (2-4 weeks) in the development of perinephritic hy...
cardiovascular diseases
Clinical features and treatment of obstructive sleep apnea. OBJECTIVE: To review the clinical features and treatment of obstructive sleep apnea (OSA). DATA SOURCE AND SELECTION: All articles on OSA published in French and English between 1970 and 1990 and indexed in Index Medicus were reviewed. Studies addressing the e...
general pathological conditions
Evidence for motor neuropathy and reduced filling of the rectum in chronic intractable constipation. Subtotal colectomy with ileorectal anastomosis is now frequently offered to patients with slow transit constipation who have severe symptoms and no response to more conventional medical treatment. If this operation is t...
nervous system diseases
The oncologic risks of skin preservation at mastectomy when combined with immediate reconstruction of the breast. Most oncologic surgeons agree that removal of the nipple, the areola and any recent scar at the site of the biopsy is necessary during a mastectomy for treatment of carcinoma of the breast. There is less ag...
neoplasms
Short-term chemoprophylaxis with ceftizoxime vs. five-day aminoglycoside with metronidazole in 'contaminated' lower gastrointestinal surgery. In a prospective, open, randomized controlled trial, 173 patients requiring surgery for potentially "contaminated" lower gastrointestinal surgery were allocated to receive either...
general pathological conditions
Percutaneous valvuloplasty in a patient with mitral stenosis following surgical annuloplasty. A case is described in which a patient with a Carpentier-Edwards annuloplasty ring developed mitral stenosis and was treated with percutaneous mitral valvuloplasty. Possible mechanisms for the development of mitral stenosis ar...
cardiovascular diseases
Nifedipine gastrointestinal therapeutic system in the treatment of hypertension. Results of a multicenter trial. The Modern Approach to the Treatment of Hypertension (MATH) Study Group. Nifedipine, in the gastrointestinal therapeutic system (GITS) formulation, a controlled-release formulation for once-a-day administrat...
cardiovascular diseases
Urinary tract dilatation in pregnancy. Right-sided ureteral and renal pelvis dilatation was observed during routine uterine ultrasonographic examination at 30 weeks' gestation. This continued to progress with the renal pelvis measuring 8.9 cm in diameter at 35 weeks, leading to early delivery. Renal function remained n...
general pathological conditions
Coronary artery bypass grafting in a patient with cryoglobulinemia. Coronary artery bypass grafting (CABG) was performed in a patient with cryoglobulinemia. In order to decrease the concentration of cryoglobulin, the patient underwent double filtration plasmapheresis (DFPP) pre- and postoperatively as well as during ca...
cardiovascular diseases
Dermatology and the human gene map. Chromosomal localization has been established for many genetic traits. Gene mapping may lead to the identification of disease genes, an understanding of pathogenesis, and the development of rational therapy, as well as facilitating antenatal diagnosis and genetic counselling. 'The ne...
general pathological conditions
Natural history of congestive gastropathy in cirrhosis. The Liver Study Group of V. Cervello Hospital. In a prospective study of the natural history of congestive gastropathy, 212 consecutive cirrhotic patients (75 treated with sclerotherapy) were included. Mean follow-up was 46 months. Mild gastropathy (mosaiclike pat...
general pathological conditions
How bad are the symptoms and bowel dysfunction of patients with the irritable bowel syndrome? A prospective, controlled study with emphasis on stool form. Since it is not known whether the symptoms and bowel function of patients with the irritable bowel syndrome are truly abnormal we used diaries and frequent telephone...
digestive system diseases
Referral of patients with primary biliary cirrhosis for liver transplantation. All patients with primary biliary cirrhosis referred to this unit for consideration for transplantation between April 1981 and January 1989 were analysed retrospectively to assess whether disease stage at referral affects the outcome after g...
general pathological conditions