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1270 32968282 pubmed Lawson KA (2020) 12-PMID32968282 19466 19466 Yes 2060 BAGEL Score Significance Score.1 (Bayes Factor) > 5.0 High Throughput Negative Selection Pool Timecourse 17 Days - - ~ 0.5 mTKO (mouseTKO) CRISPRn Knockout Cas9 B16-MO4 Melanoma Cell Line cell proliferation 1 Bayes Factor - - - - 10090 M. muscul... |
1271 32968282 pubmed Lawson KA (2020) 13-PMID32968282 18680 18680 Yes 332 DrugZ Score Significance Score.2 (FDR) < 0.05 High Throughput Positive and Negative Selection Pool T cell exposure 15 Days cytotoxic T lymphocytes (CTLs) - ~ 0.5 mTKO (mouseTKO) CRISPRn Knockout Cas9 RenCa Mouse kidney carcinoma cell cell prolife... |
1272 32968282 pubmed Lawson KA (2020) 14-PMID32968282 18983 18983 Yes 471 DrugZ Score Significance Score.2 (FDR) < 0.05 High Throughput Positive and Negative Selection Pool T cell exposure 24 Days cytotoxic T lymphocytes (CTLs) - ~ 0.5 mTKO (mouseTKO) CRISPRn Knockout Cas9 RenCa Mouse kidney carcinoma cell cell prolife... |
1273 32968282 pubmed Lawson KA (2020) 15-PMID32968282 19041 19041 Yes 780 DrugZ Score Significance Score.2 (FDR) < 0.05 High Throughput Positive and Negative Selection Pool T cell exposure 11 Days cytotoxic T lymphocytes (CTLs) - ~ 0.5 mTKO (mouseTKO) CRISPRn Knockout Cas9 EMT6 Mammary Gland Tumor Cell Line cell prolif... |
1274 32968282 pubmed Lawson KA (2020) 16-PMID32968282 18986 18986 Yes 624 DrugZ Score Significance Score.2 (FDR) < 0.05 High Throughput Positive and Negative Selection Pool T cell exposure 19 Days cytotoxic T lymphocytes (CTLs) - ~ 0.5 mTKO (mouseTKO) CRISPRn Knockout Cas9 EMT6 Mammary Gland Tumor Cell Line cell prolif... |
1275 32968282 pubmed Lawson KA (2020) 17-PMID32968282 19060 19060 Yes 493 DrugZ Score Significance Score.2 (FDR) < 0.05 High Throughput Positive and Negative Selection Pool T cell exposure 11 Days cytotoxic T lymphocytes (CTLs) - ~ 0.5 mTKO (mouseTKO) CRISPRn Knockout Cas9 CT26 Colonic Cancer Cell Line cell proliferati... |
1276 32968282 pubmed Lawson KA (2020) 18-PMID32968282 19032 19032 Yes 451 DrugZ Score Significance Score.2 (FDR) < 0.05 High Throughput Positive and Negative Selection Pool T cell exposure 17 Days cytotoxic T lymphocytes (CTLs) - ~ 0.5 mTKO (mouseTKO) CRISPRn Knockout Cas9 CT26 Colonic Cancer Cell Line cell proliferati... |
1277 32968282 pubmed Lawson KA (2020) 19-PMID32968282 19011 19011 Yes 243 DrugZ Score Significance Score.2 (FDR) < 0.05 High Throughput Positive and Negative Selection Pool T cell exposure 14 Days cytotoxic T lymphocytes (CTLs) - ~ 0.5 mTKO (mouseTKO) CRISPRn Knockout Cas9 4T1 Breast Adenocarcinoma Cell Line cell proli... |
1278 32968282 pubmed Lawson KA (2020) 20-PMID32968282 18625 18625 Yes 167 DrugZ Score Significance Score.2 (FDR) < 0.05 High Throughput Positive and Negative Selection Pool T cell exposure 25 Days cytotoxic T lymphocytes (CTLs) - ~ 0.5 mTKO (mouseTKO) CRISPRn Knockout Cas9 4T1 Breast Adenocarcinoma Cell Line cell proli... |
1279 32968282 pubmed Lawson KA (2020) 21-PMID32968282 19046 19046 Yes 125 DrugZ Score Significance Score.2 (FDR) < 0.05 High Throughput Positive and Negative Selection Pool T cell exposure 12 Days cytotoxic T lymphocytes (CTLs) - ~ 0.5 mTKO (mouseTKO) CRISPRn Knockout Cas9 MC38-OVA Colonic Adenocarcinoma Cell Line cell... |
1280 32968282 pubmed Lawson KA (2020) 22-PMID32968282 18638 18638 Yes 44 DrugZ Score Significance Score.2 (FDR) < 0.05 High Throughput Positive and Negative Selection Pool T cell exposure 15 Days cytotoxic T lymphocytes (CTLs) - ~ 0.5 mTKO (mouseTKO) CRISPRn Knockout Cas9 MC38-OVA Colonic Adenocarcinoma Cell Line cell ... |
1281 32968282 pubmed Lawson KA (2020) 23-PMID32968282 19065 19065 Yes 119 DrugZ Score Significance Score.2 (FDR) < 0.05 High Throughput Positive and Negative Selection Pool T cell exposure 13 Days cytotoxic T lymphocytes (CTLs) - ~ 0.5 mTKO (mouseTKO) CRISPRn Knockout Cas9 B16-MO4 Melanoma Cell Line cell proliferation ... |
1282 32968282 pubmed Lawson KA (2020) 24-PMID32968282 19060 19060 Yes 116 DrugZ Score Significance Score.2 (FDR) < 0.05 High Throughput Positive and Negative Selection Pool T cell exposure 17 Days cytotoxic T lymphocytes (CTLs) - ~ 0.5 mTKO (mouseTKO) CRISPRn Knockout Cas9 B16-MO4 Melanoma Cell Line cell proliferation ... |
1283 32968282 pubmed Lawson KA (2020) 25-PMID32968282 19063 19063 Yes 139 DrugZ Score Significance Score.3 (FDR) < 0.05 OR Score.5 (FDR) < 0.05 High Throughput Positive and Negative Selection Pool Cytokine exposure 15 Days Interferon gamma 10.0 ng/mL ~ 0.5 mTKO (mouseTKO) CRISPRn Knockout Cas9 RenCa Mouse kidney carcin... |
1284 32968282 pubmed Lawson KA (2020) 26-PMID32968282 19045 19045 Yes 236 DrugZ Score Significance Score.3 (FDR) < 0.05 OR Score.5 (FDR) < 0.05 High Throughput Positive and Negative Selection Pool Cytokine exposure 24 Days Interferon gamma 10.0 ng/mL ~ 0.5 mTKO (mouseTKO) CRISPRn Knockout Cas9 RenCa Mouse kidney carcin... |
1285 32968282 pubmed Lawson KA (2020) 27-PMID32968282 19059 19059 Yes 931 DrugZ Score Significance Score.3 (FDR) < 0.05 OR Score.5 (FDR) < 0.05 High Throughput Positive and Negative Selection Pool Cytokine exposure 15 Days Mutation: FITM2 (ETG228859) KO|IFNgamma 10.0 ng/mL ~ 0.5 mTKO (mouseTKO) CRISPRn Knockout Cas9 Re... |
1286 32968282 pubmed Lawson KA (2020) 28-PMID32968282 18972 18972 Yes 513 DrugZ Score Significance Score.3 (FDR) < 0.05 OR Score.5 (FDR) < 0.05 High Throughput Positive and Negative Selection Pool Cytokine exposure 24 Days Mutation: FITM2 (ETG228859) KO|IFNgamma 10.0 ng/mL ~ 0.5 mTKO (mouseTKO) CRISPRn Knockout Cas9 Re... |
1287 32968282 pubmed Lawson KA (2020) 29-PMID32968282 19064 19064 Yes 259 DrugZ Score Significance Score.3 (FDR) < 0.05 OR Score.5 (FDR) < 0.05 High Throughput Positive and Negative Selection Pool Cytokine exposure 15 Days TNF‐α 10.0 ng/mL ~ 0.5 mTKO (mouseTKO) CRISPRn Knockout Cas9 RenCa Mouse kidney carcinoma cell ce... |
1288 32968282 pubmed Lawson KA (2020) 30-PMID32968282 19050 19050 Yes 214 DrugZ Score Significance Score.3 (FDR) < 0.05 OR Score.5 (FDR) < 0.05 High Throughput Positive and Negative Selection Pool Cytokine exposure 24 Days TNF‐α 10.0 ng/mL ~ 0.5 mTKO (mouseTKO) CRISPRn Knockout Cas9 RenCa Mouse kidney carcinoma cell ce... |
1289 32968282 pubmed Lawson KA (2020) 31-PMID32968282 19058 19058 Yes 904 DrugZ Score Significance Score.3 (FDR) < 0.05 OR Score.5 (FDR) < 0.05 High Throughput Positive and Negative Selection Pool Cytokine exposure 15 Days Mutation: ATG12 (ETG67526) KO | TNF 10.0 ng/mL ~ 0.5 mTKO (mouseTKO) CRISPRn Knockout Cas9 RenCa ... |
1290 32968282 pubmed Lawson KA (2020) 32-PMID32968282 19032 19032 Yes 924 DrugZ Score Significance Score.3 (FDR) < 0.05 OR Score.5 (FDR) < 0.05 High Throughput Positive and Negative Selection Pool Cytokine exposure 24 Days Mutation: ATG12 (ETG67526) KO | TNF 10.0 ng/mL ~ 0.5 mTKO (mouseTKO) CRISPRn Knockout Cas9 RenCa ... |
1358 31346084 pubmed Orvedahl A (2019) 1-PMID31346084 1536 20147 No 14 STARS Score Significance Score.1 (STARS Score) > 0.0 AND Score.2 (FDR) < 0.1 High Throughput Positive Selection Pool Ligand Exposure 7 Days Interferon gamma 10.0 units/mL - Brie (mouse) CRISPRn Knockout Cas9 BV-2 Microglial Cell Line cell proliferat... |
1359 31346084 pubmed Orvedahl A (2019) 2-PMID31346084 1700 20147 No 9 STARS Score Significance Score.1 (STARS Score) > 0.0 AND Score.2 (FDR) < 0.1 High Throughput Positive Selection Pool Ligand Exposure 7 Days Interferon gamma 10.0 units/mL - Brie (mouse) CRISPRn Knockout Cas9 BV-2 Microglial Cell Line cell proliferati... |
1398 31038839 pubmed Kim B (2019) 1-PMID31038839 19672 19672 Yes 10 MaGeCK Score Significance Score.2 (p-Value) < 0.0005 High Throughput Phenotype Screen Pool Timecourse 8 Doublings - - - Brie (mouse) CRISPRn Knockout Cas9 BV-2 Microglial Cell Line protein/peptide accumulation 4 MaGeCK Score p-Value FDR Log2FC - 10090 ... |
1399 31038839 pubmed Kim B (2019) 2-PMID31038839 19672 19672 Yes 10 MaGeCK Score Significance Score.2 (p-Value) < 0.0005 High Throughput Phenotype Screen Pool Timecourse 9 Doublings - - - Brie (mouse) CRISPRn Knockout Cas9 BV-2 Microglial Cell Line protein/peptide accumulation 4 MaGeCK Score p-Value FDR Log2FC - 10090 ... |
1422 33208938 pubmed Ma H (2020) 1-PMID33208938 22468 22468 Yes 56 MaGeCK Score Significance Score.2 (p-Value) < 0.01 High Throughput Phenotype Screen Pool Virus Exposure 54 Hours Virus: Venezuelan equine encephalitis virus (VEEV) based chimera (SINV–VEEV–GFP) 1 MOI ~ 0.1 GECKO v2 (mouse) CRISPRn Knockout Cas9 Neuro-2... |
1438 33087464 pubmed Urbanek K (2020) 1-PMID33087464 5382 20077 No 895 STARS Score Significance Score.3 (FDR) < 0.25 High Throughput Positive Selection Pool Virus Exposure 9 Days Virus: Reovirus (strain T3SA+) 100.0 MOI = 0.2 Asagio (mouse) CRISPRn Knockout Cas9 BV-2 Microglial Cell Line response to virus 3 STARS Score... |
1439 33087464 pubmed Urbanek K (2020) 2-PMID33087464 6736 20077 No 52 STARS Score Significance Score.3 (FDR) < 0.25 High Throughput Positive Selection Pool Virus Exposure 9 Days Virus: Reovirus (strain T3SA-) 100.0 MOI = 0.2 Asagio (mouse) CRISPRn Knockout Cas9 BV-2 Microglial Cell Line response to virus 3 STARS Score ... |
1440 31209294 pubmed Fu X (2019) 2-PMID31209294 20646 20646 Yes 477 MaGeCK Score Significance Score.2 (neg score p-value) < 0.01 OR Score.4 (pos score p-value) < 0.01 High Throughput Phenotype Screen Pool Other 1 Days Dux gene induction - - Brie (mouse) CRISPRn Knockout Cas9 Mouse Embryonic Stem Cell Embryonic Cell Lin... |
1460 33157015 pubmed Bieging-Rolett KT (2020) 1-PMID33157015 89 89 Yes 11 CasTLE Score Significance Score.1 (CasTLE Effect) > 0.0 AND Score.2 (p-Value) < 0.05 High Throughput Positive Selection in vivo Implantation to Mouse Model 3 Weeks Mutation: HrasG12V (ETG15461) - = 0.2 TSAG library CRISPRn Knockout Cas9 MEF Embry... |
1468 33185187 pubmed Fomicheva M (2020) 1-PMID33185187 22619 22619 Yes 6 MaGeCK Score Significance Score.3 (FDR) < 0.25 High Throughput Phenotype Screen Pool Timecourse 14 Days - - = 0.3 GECKO v2 (mouse) CRISPRn Knockout Cas9 EpH4 breast epithelium cell cycle progression 3 MaGeCK Score p-Value FDR - - 10090 M. musculus... |
1469 33185187 pubmed Fomicheva M (2020) 2-PMID33185187 22619 22619 Yes 4 MaGeCK Score Significance Score.3 (FDR) < 0.25 High Throughput Phenotype Screen Pool Timecourse 28 Days - - = 0.3 GECKO v2 (mouse) CRISPRn Knockout Cas9 EpH4 breast epithelium cell cycle progression 3 MaGeCK Score p-Value FDR - - 10090 M. musculus... |
1470 33185187 pubmed Fomicheva M (2020) 3-PMID33185187 22619 22619 Yes 6 MaGeCK Score Significance Score.3 (FDR) < 0.25 High Throughput Positive Selection Pool Timecourse 42 Days - - = 0.3 GECKO v2 (mouse) CRISPRn Knockout Cas9 EpH4 breast epithelium cell cycle progression 3 MaGeCK Score p-Value FDR - - 10090 M. muscul... |
1481 32640256 pubmed Loo CS (2020) 1-PMID32640256 19668 19668 Yes 490 MaGeCK Score Significance Score.2 (p-Value) < 0.01 AND Score.3 (Log2FC) < -0.5 High Throughput Phenotype Screen Pool Timecourse 6 Days - - < 0.2 Brie (mouse) CRISPRn Knockout Cas9 primary Treg Regulatory T cell protein/peptide accumulation 3 MAGeCK n... |
1482 32640256 pubmed Loo CS (2020) 2-PMID32640256 19668 19668 Yes 254 MaGeCK Score Significance Score.2 (p-Value) < 0.01 AND Score.3 (Log2FC) > 0.5 High Throughput Phenotype Screen Pool Timecourse 6 Days - - < 0.2 Brie (mouse) CRISPRn Knockout Cas9 primary Treg Regulatory T cell protein/peptide accumulation 3 MAGeCK po... |
1483 32640256 pubmed Loo CS (2020) 3-PMID32640256 19674 19674 Yes 1497 MaGeCK Score Significance Score.2 (p-Value) < 0.002 AND Score.3 (Log2FC) < -1.0 High Throughput Negative Selection Pool Timecourse 6 Days - - < 0.2 Brie (mouse) CRISPRn Knockout Cas9 primary Treg Regulatory T cell cell proliferation 3 MaGeCK Score p... |
1484 32640256 pubmed Loo CS (2020) 4-PMID32640256 19674 19674 Yes 22 MaGeCK Score Significance Score.2 (p-Value) < 0.002 AND Score.3 (Log2FC) >= 0.65567 High Throughput Positive Selection Pool Timecourse 6 Days - - < 0.2 Brie (mouse) CRISPRn Knockout Cas9 primary Treg Regulatory T cell cell proliferation 3 MaGeCK Score... |
1489 32156810 pubmed Ma H (2020) 1-PMID32156810 200 20077 No 200 MaGeCK All Significant - High Throughput Phenotype Screen Pool Cytokine exposure 16 Hours IFN-β (Interferon beta) 40.0 IU/ml - Asagio (mouse) CRISPRn Knockout Cas9 BV-2 Microglial Cell Line protein/peptide accumulation 3 MaGeCK Score p-Value FDR - - 10090... |
1490 32156810 pubmed Ma H (2020) 2-PMID32156810 200 20077 No 200 MaGeCK All Significant - High Throughput Phenotype Screen Pool Cytokine exposure 16 Hours IFN-β (Interferon beta) 40.0 IU/ml - Asagio (mouse) CRISPRn Knockout Cas9 BV-2 Microglial Cell Line protein/peptide accumulation 3 MaGeCK Score p-Value FDR - - 10090... |
1521 31657721 pubmed Kinnebrew M (2019) 1-PMID31657721 1239 1239 Yes 253 MaGeCK Score Significance Score.1 (p-Value) < 0.1 High Throughput Phenotype Screen Pool Ligand Exposure 24 Hours Sonic hedgehog protein (mouse) 3.2 nM - Targeted lipid-related genes library (Rohatgi, 2019) CRISPRn Knockout Cas9 NIH 3T3 Embryonic F... |
1522 31657721 pubmed Kinnebrew M (2019) 2-PMID31657721 1239 1239 Yes 190 MaGeCK Score Significance Score.1 (p-Value) < 0.1 High Throughput Phenotype Screen Pool Ligand Exposure 24 Hours Sonic hedgehog protein (mouse) 25 nM - Targeted lipid-related genes library (Rohatgi, 2019) CRISPRn Knockout Cas9 NIH 3T3 Embryonic Fi... |
1523 32355287 pubmed Liu X (2020) 1-PMID32355287 566 566 Yes 27 MaGeCK Score Significance Score.1 (p-Value) < 0.05 AND Score.2 (FDR) < 0.05 Low Throughput Negative Selection Pool Drug Exposure 12 Days 6-Mercaptopurine 0.5 µM - CRISPRn targeted mouse library (Liu, 2020) CRISPRn Knockout Cas9 CH12F3 Lymphoma Cell Line re... |
1525 32355287 pubmed Liu X (2020) 2-PMID32355287 566 566 Yes 51 MaGeCK Score Significance Score.1 (p-Value) < 0.05 AND Score.2 (FDR) < 0.05 Low Throughput Negative Selection Pool Drug Exposure 12 Days A-966492 2.5 µM - CRISPRn targeted mouse library (Liu, 2020) CRISPRn Knockout Cas9 CH12F3 Lymphoma Cell Line response t... |
1526 32355287 pubmed Liu X (2020) 3-PMID32355287 566 566 Yes 43 MaGeCK Score Significance Score.1 (p-Value) < 0.05 AND Score.2 (FDR) < 0.05 Low Throughput Negative Selection Pool Drug Exposure 12 Days ABT-888 5 µM - CRISPRn targeted mouse library (Liu, 2020) CRISPRn Knockout Cas9 CH12F3 Lymphoma Cell Line response to c... |
1527 32355287 pubmed Liu X (2020) 4-PMID32355287 566 566 Yes 26 MaGeCK Score Significance Score.1 (p-Value) < 0.05 AND Score.2 (FDR) < 0.05 Low Throughput Negative Selection Pool Drug Exposure 12 Days Amonafide 0.25 µM - CRISPRn targeted mouse library (Liu, 2020) CRISPRn Knockout Cas9 CH12F3 Lymphoma Cell Line response... |
1528 32355287 pubmed Liu X (2020) 5-PMID32355287 566 566 Yes 32 MaGeCK Score Significance Score.1 (p-Value) < 0.05 AND Score.2 (FDR) < 0.05 Low Throughput Negative Selection Pool Drug Exposure 12 Days Amsacrine 25.84 nM - CRISPRn targeted mouse library (Liu, 2020) CRISPRn Knockout Cas9 CH12F3 Lymphoma Cell Line respons... |
1529 32355287 pubmed Liu X (2020) 6-PMID32355287 566 566 Yes 30 MaGeCK Score Significance Score.1 (p-Value) < 0.05 AND Score.2 (FDR) < 0.05 Low Throughput Negative Selection Pool Drug Exposure 12 Days 5-Azacytidine 0.125 µM - CRISPRn targeted mouse library (Liu, 2020) CRISPRn Knockout Cas9 CH12F3 Lymphoma Cell Line res... |
1530 32355287 pubmed Liu X (2020) 7-PMID32355287 566 566 Yes 56 MaGeCK Score Significance Score.1 (p-Value) < 0.05 AND Score.2 (FDR) < 0.05 Low Throughput Negative Selection Pool Drug Exposure 12 Days AZD-2461 2.5 µM - CRISPRn targeted mouse library (Liu, 2020) CRISPRn Knockout Cas9 CH12F3 Lymphoma Cell Line response t... |
1531 32355287 pubmed Liu X (2020) 8-PMID32355287 566 566 Yes 29 MaGeCK Score Significance Score.1 (p-Value) < 0.05 AND Score.2 (FDR) < 0.05 Low Throughput Negative Selection Pool Drug Exposure 12 Days BMH-21 100 nM - CRISPRn targeted mouse library (Liu, 2020) CRISPRn Knockout Cas9 CH12F3 Lymphoma Cell Line response to ... |
1532 32355287 pubmed Liu X (2020) 9-PMID32355287 566 566 Yes 21 MaGeCK Score Significance Score.1 (p-Value) < 0.05 AND Score.2 (FDR) < 0.05 Low Throughput Negative Selection Pool Drug Exposure 12 Days Cytarabine 100 nM - CRISPRn targeted mouse library (Liu, 2020) CRISPRn Knockout Cas9 CH12F3 Lymphoma Cell Line response... |
1533 32355287 pubmed Liu X (2020) 10-PMID32355287 566 566 Yes 41 MaGeCK Score Significance Score.1 (p-Value) < 0.05 AND Score.2 (FDR) < 0.05 Low Throughput Negative Selection Pool Drug Exposure 12 Days Dacarbazine 0.5 µM - CRISPRn targeted mouse library (Liu, 2020) CRISPRn Knockout Cas9 CH12F3 Lymphoma Cell Line respon... |
1534 32355287 pubmed Liu X (2020) 11-PMID32355287 566 566 Yes 52 MaGeCK Score Significance Score.1 (p-Value) < 0.05 AND Score.2 (FDR) < 0.05 Low Throughput Negative Selection Pool Drug Exposure 12 Days Daunorubicin 31.6 nM - CRISPRn targeted mouse library (Liu, 2020) CRISPRn Knockout Cas9 CH12F3 Lymphoma Cell Line resp... |
1535 32355287 pubmed Liu X (2020) 12-PMID32355287 566 566 Yes 36 MaGeCK Score Significance Score.1 (p-Value) < 0.05 AND Score.2 (FDR) < 0.05 Low Throughput Negative Selection Pool Drug Exposure 12 Days DR 2313 9.146 µM - CRISPRn targeted mouse library (Liu, 2020) CRISPRn Knockout Cas9 CH12F3 Lymphoma Cell Line response... |
1536 32355287 pubmed Liu X (2020) 13-PMID32355287 566 566 Yes 48 MaGeCK Score Significance Score.1 (p-Value) < 0.05 AND Score.2 (FDR) < 0.05 Low Throughput Negative Selection Pool Drug Exposure 12 Days Ellipticine 0.147 µM - CRISPRn targeted mouse library (Liu, 2020) CRISPRn Knockout Cas9 CH12F3 Lymphoma Cell Line resp... |
1537 32355287 pubmed Liu X (2020) 14-PMID32355287 566 566 Yes 55 MaGeCK Score Significance Score.1 (p-Value) < 0.05 AND Score.2 (FDR) < 0.05 Low Throughput Negative Selection Pool Drug Exposure 12 Days Epirubicin 0.192 µM - CRISPRn targeted mouse library (Liu, 2020) CRISPRn Knockout Cas9 CH12F3 Lymphoma Cell Line respo... |
1538 32355287 pubmed Liu X (2020) 15-PMID32355287 566 566 Yes 43 MaGeCK Score Significance Score.1 (p-Value) < 0.05 AND Score.2 (FDR) < 0.05 Low Throughput Negative Selection Pool Drug Exposure 12 Days Etoposide 25 nM - CRISPRn targeted mouse library (Liu, 2020) CRISPRn Knockout Cas9 CH12F3 Lymphoma Cell Line response ... |
1539 32355287 pubmed Liu X (2020) 16-PMID32355287 566 566 Yes 17 MaGeCK Score Significance Score.1 (p-Value) < 0.05 AND Score.2 (FDR) < 0.05 Low Throughput Negative Selection Pool Drug Exposure 12 Days EX-527 2.5 µM - CRISPRn targeted mouse library (Liu, 2020) CRISPRn Knockout Cas9 CH12F3 Lymphoma Cell Line response to... |
1540 32355287 pubmed Liu X (2020) 17-PMID32355287 566 566 Yes 57 MaGeCK Score Significance Score.1 (p-Value) < 0.05 AND Score.2 (FDR) < 0.05 Low Throughput Negative Selection Pool Drug Exposure 12 Days Hydroxycamptothecin 13.06 nM - CRISPRn targeted mouse library (Liu, 2020) CRISPRn Knockout Cas9 CH12F3 Lymphoma Cell L... |
1541 32355287 pubmed Liu X (2020) 18-PMID32355287 566 566 Yes 1 MaGeCK Score Significance Score.1 (p-Value) < 0.05 AND Score.2 (FDR) < 0.05 Low Throughput Negative Selection Pool Drug Exposure 12 Days Hydroxyurea 25 µM - CRISPRn targeted mouse library (Liu, 2020) CRISPRn Knockout Cas9 CH12F3 Lymphoma Cell Line response... |
1542 32355287 pubmed Liu X (2020) 19-PMID32355287 566 566 Yes 66 MaGeCK Score Significance Score.1 (p-Value) < 0.05 AND Score.2 (FDR) < 0.05 Low Throughput Negative Selection Pool Drug Exposure 12 Days Irinotecan 1.25 µM - CRISPRn targeted mouse library (Liu, 2020) CRISPRn Knockout Cas9 CH12F3 Lymphoma Cell Line respon... |
1543 32355287 pubmed Liu X (2020) 20-PMID32355287 566 566 Yes 52 MaGeCK Score Significance Score.1 (p-Value) < 0.05 AND Score.2 (FDR) < 0.05 Low Throughput Negative Selection Pool Drug Exposure 12 Days KU-57788 0.5 µM - CRISPRn targeted mouse library (Liu, 2020) CRISPRn Knockout Cas9 CH12F3 Lymphoma Cell Line response ... |
1544 32355287 pubmed Liu X (2020) 21-PMID32355287 566 566 Yes 39 MaGeCK Score Significance Score.1 (p-Value) < 0.05 AND Score.2 (FDR) < 0.05 Low Throughput Negative Selection Pool Drug Exposure 12 Days KU-60019 1 µM - CRISPRn targeted mouse library (Liu, 2020) CRISPRn Knockout Cas9 CH12F3 Lymphoma Cell Line response to... |
1545 32355287 pubmed Liu X (2020) 22-PMID32355287 566 566 Yes 55 MaGeCK Score Significance Score.1 (p-Value) < 0.05 AND Score.2 (FDR) < 0.05 Low Throughput Negative Selection Pool Drug Exposure 12 Days Melphalan 1 µM - CRISPRn targeted mouse library (Liu, 2020) CRISPRn Knockout Cas9 CH12F3 Lymphoma Cell Line response t... |
1546 32355287 pubmed Liu X (2020) 23-PMID32355287 566 566 Yes 63 MaGeCK Score Significance Score.1 (p-Value) < 0.05 AND Score.2 (FDR) < 0.05 Low Throughput Negative Selection Pool Drug Exposure 12 Days Mitomycin C 25 nM - CRISPRn targeted mouse library (Liu, 2020) CRISPRn Knockout Cas9 CH12F3 Lymphoma Cell Line respons... |
1547 32355287 pubmed Liu X (2020) 24-PMID32355287 566 566 Yes 50 MaGeCK Score Significance Score.1 (p-Value) < 0.05 AND Score.2 (FDR) < 0.05 Low Throughput Negative Selection Pool Drug Exposure 12 Days MK-4827 0.5 µM - CRISPRn targeted mouse library (Liu, 2020) CRISPRn Knockout Cas9 CH12F3 Lymphoma Cell Line response t... |
1548 32355287 pubmed Liu X (2020) 25-PMID32355287 566 566 Yes 59 MaGeCK Score Significance Score.1 (p-Value) < 0.05 AND Score.2 (FDR) < 0.05 Low Throughput Negative Selection Pool Drug Exposure 12 Days Methyl methanesulfonate (MMS) 50 µM - CRISPRn targeted mouse library (Liu, 2020) CRISPRn Knockout Cas9 CH12F3 Lymphoma... |
1549 32355287 pubmed Liu X (2020) 26-PMID32355287 566 566 Yes 58 MaGeCK Score Significance Score.1 (p-Value) < 0.05 AND Score.2 (FDR) < 0.05 Low Throughput Negative Selection Pool Drug Exposure 12 Days Olaparib 1.25 µM - CRISPRn targeted mouse library (Liu, 2020) CRISPRn Knockout Cas9 CH12F3 Lymphoma Cell Line response... |
1550 32355287 pubmed Liu X (2020) 27-PMID32355287 566 566 Yes 48 MaGeCK Score Significance Score.1 (p-Value) < 0.05 AND Score.2 (FDR) < 0.05 Low Throughput Negative Selection Pool Drug Exposure 12 Days Oxaliplatin 0.25 µM - CRISPRn targeted mouse library (Liu, 2020) CRISPRn Knockout Cas9 CH12F3 Lymphoma Cell Line respo... |
1551 32355287 pubmed Liu X (2020) 28-PMID32355287 566 566 Yes 64 MaGeCK Score Significance Score.1 (p-Value) < 0.05 AND Score.2 (FDR) < 0.05 Low Throughput Negative Selection Pool Drug Exposure 12 Days Pirarubicin 50 nM - CRISPRn targeted mouse library (Liu, 2020) CRISPRn Knockout Cas9 CH12F3 Lymphoma Cell Line respons... |
1552 32355287 pubmed Liu X (2020) 29-PMID32355287 566 566 Yes 36 MaGeCK Score Significance Score.1 (p-Value) < 0.05 AND Score.2 (FDR) < 0.05 Low Throughput Negative Selection Pool Drug Exposure 12 Days Pyridostatin 0.5 µM - CRISPRn targeted mouse library (Liu, 2020) CRISPRn Knockout Cas9 CH12F3 Lymphoma Cell Line respo... |
1553 32355287 pubmed Liu X (2020) 30-PMID32355287 566 566 Yes 49 MaGeCK Score Significance Score.1 (p-Value) < 0.05 AND Score.2 (FDR) < 0.05 Low Throughput Negative Selection Pool Drug Exposure 12 Days Rucaparib 1.25 µM - CRISPRn targeted mouse library (Liu, 2020) CRISPRn Knockout Cas9 CH12F3 Lymphoma Cell Line respons... |
1554 32355287 pubmed Liu X (2020) 31-PMID32355287 566 566 Yes 60 MaGeCK Score Significance Score.1 (p-Value) < 0.05 AND Score.2 (FDR) < 0.05 Low Throughput Negative Selection Pool Drug Exposure 12 Days SN-38 10 nM - CRISPRn targeted mouse library (Liu, 2020) CRISPRn Knockout Cas9 CH12F3 Lymphoma Cell Line response to c... |
1555 32355287 pubmed Liu X (2020) 32-PMID32355287 566 566 Yes 22 MaGeCK Score Significance Score.1 (p-Value) < 0.05 AND Score.2 (FDR) < 0.05 Low Throughput Negative Selection Pool Drug Exposure 12 Days SRT 1720 2.5 µM - CRISPRn targeted mouse library (Liu, 2020) CRISPRn Knockout Cas9 CH12F3 Lymphoma Cell Line response ... |
1556 32355287 pubmed Liu X (2020) 33-PMID32355287 566 566 Yes 49 MaGeCK Score Significance Score.1 (p-Value) < 0.05 AND Score.2 (FDR) < 0.05 Low Throughput Negative Selection Pool Drug Exposure 12 Days Thio-TEPA 1 µM - CRISPRn targeted mouse library (Liu, 2020) CRISPRn Knockout Cas9 CH12F3 Lymphoma Cell Line response t... |
1557 32355287 pubmed Liu X (2020) 34-PMID32355287 566 566 Yes 56 MaGeCK Score Significance Score.1 (p-Value) < 0.05 AND Score.2 (FDR) < 0.05 Low Throughput Negative Selection Pool Drug Exposure 12 Days Topotecan 25 nM - CRISPRn targeted mouse library (Liu, 2020) CRISPRn Knockout Cas9 CH12F3 Lymphoma Cell Line response ... |
1558 32355287 pubmed Liu X (2020) 35-PMID32355287 566 566 Yes 65 MaGeCK Score Significance Score.1 (p-Value) < 0.05 AND Score.2 (FDR) < 0.05 Low Throughput Negative Selection Pool Drug Exposure 12 Days Treosulfan 2.5 µM - CRISPRn targeted mouse library (Liu, 2020) CRISPRn Knockout Cas9 CH12F3 Lymphoma Cell Line respons... |
1559 32355287 pubmed Liu X (2020) 36-PMID32355287 566 566 Yes 74 MaGeCK Score Significance Score.1 (p-Value) < 0.05 AND Score.2 (FDR) < 0.05 Low Throughput Negative Selection Pool Drug Exposure 12 Days Zeocin 2.5 µg/mL - CRISPRn targeted mouse library (Liu, 2020) CRISPRn Knockout Cas9 CH12F3 Lymphoma Cell Line response... |
1565 33676427 pubmed Du R (2021) 1-PMID33676427 19674 19674 Yes 1943 MaGeCK Score Significance Score.3 (FDR) < 0.05 High Throughput Negative Selection Pool Drug Exposure 12 Days salirasib (Farnesyl Thiosalicylic Acid) 100.0 µM - Brie (mouse) CRISPRn Knockout Cas9 4292 KRASG12D/p53R172H Pancreatic Ductal Adenocarcinoma... |
1570 32499641 pubmed Cortez JT (2020) 1-PMID32499641 493 493 Yes 41 MaGeCK Score Significance Score.2 (FDR) < 0.5 OR Score.4 (FDR) < 0.5 High Throughput Phenotype Screen Pool Timecourse 8 Days - - - CRISPRn Nuclear Factor Targeted Library based on Brie sgRNAs CRISPRn Knockout Cas9 primary Treg Regulatory T cell protein... |
1585 33372156 pubmed Balce DR (2021) 1-PMID33372156 17448 17448 Yes 229 Log2 Fold Change (L2FC) Score Significance Score.1 (Log2FC) > 0.0 AND Score.2 (p-Value) > 1.3 High Throughput Phenotype Screen Pool Cytokine exposure 20 Hours Interferon gamma 2.0 units/mL - Asagio (mouse) CRISPRn Knockout Cas9 BV-2 Microglial Cell... |
1587 30944478 pubmed Pluvinage JV (2019) 1-PMID30944478 2967 2967 Yes 286 CasTLE Score Significance Score.2 (p-Value) < 0.05 High Throughput Phenotype Screen Pool Drug Exposure 7 Days - - < 1 Bassik Mouse CRISPR Knockout Library: Drug targets, kinases, phosphatases and Membrane Proteins sub-libraries CRISPRn Knockout ... |
1662 34290256 pubmed VanDusen NJ (2021) 1-PMID34290256 2444 2444 Yes 262 MaGeCK Score Significance Score.2 (p-Value) < 0.05 OR Score.4 (p-Value) < 0.05 High Throughput Phenotype Screen in vivo Timecourse 4 Weeks - - - Murine Transcriptional Regulator Library (Pu, 2021) CRISPRn Knockout Cas9 cardiomyocyte cell line card... |
1663 34582788 pubmed Wang X (2021) 1-PMID34582788 4721 4721 Yes 265 MaGeCK Score Significance Score.2 (p-Value) < 0.001 OR Score.4 (p-Value) < 0.001 High Throughput Positive and Negative Selection Pool Timecourse 10 Passages - - ~ 0.3 MusCK CRISPRn Knockout Cas9 4T1 Breast Adenocarcinoma Cell Line cell proliferation 5 ... |
1664 34582788 pubmed Wang X (2021) 2-PMID34582788 4776 4776 Yes 12 MaGeCK Score Significance Score.2 (p-Value) < 0.001 OR Score.4 (p-Value) < 0.001 High Throughput Positive and Negative Selection in vivo Implantation to Mouse Model 16 Days BALB/c VS. BALB/c Foxn1nu/nu hosts - ~ 0.3 MusCK CRISPRn Knockout Cas9 4T1 Breas... |
1666 34582788 pubmed Wang X (2021) 3-PMID34582788 83 83 Yes 6 MaGeCK Score Significance Score.2 (p-Value) < 0.001 OR Score.4 (p-Value) < 0.001 High Throughput Positive and Negative Selection in vivo Implantation to Mouse Model 16 Days BALB/c VS. BALB/c Foxn1nu/nu hosts - ~ 0.3 MusCK 2.0 CRISPRn Knockout Cas9 4T1 Breast... |
1667 34582788 pubmed Wang X (2021) 4-PMID34582788 83 83 Yes 9 MaGeCK Score Significance Score.2 (p-Value) < 0.001 OR Score.4 (p-Value) < 0.001 High Throughput Positive and Negative Selection in vivo Implantation to Mouse Model 16 Days BALB/c +OVA VS. BALB/c Foxn1nu/nu hosts - ~ 0.3 MusCK 2.0 CRISPRn Knockout Cas9 4T1 B... |
1668 34582788 pubmed Wang X (2021) 5-PMID34582788 83 83 Yes 6 MaGeCK Score Significance Score.2 (p-Value) < 0.001 OR Score.4 (p-Value) < 0.001 High Throughput Positive and Negative Selection in vivo Implantation to Mouse Model 16 Days BALB/c +OVA+anti-PD-1 antibody VS. BALB/c Foxn1nu/nu hosts - ~ 0.3 MusCK 2.0 CRISPRn ... |
1678 31959936 pubmed Marschallinger J (2020) 1-PMID31959936 2807 2807 Yes 219 CasTLE Score Significance Score.3 (p-Value) < 0.05 High Throughput Phenotype Screen Pool Timecourse 90 Hours 5 μg/ml LPS in DMEM with 5% FBS - < 1.0 CRISPRn targeted library (Wyss-Coray, 2020) CRISPRn Knockout Cas9 BV-2 Microglial Cell Line r... |
1679 31618756 pubmed Hoshino A (2019) 1-PMID31618756 19983 19983 Yes 3198 Delta Z scores Column Significance - High Throughput Phenotype Screen Pool Drug Exposure 10 Days CCCP 13.0 µM ~ 0.5 GECKO v2 (mouse) CRISPRn Knockout Cas9 C2C12 myoblast cell line protein/peptide distribution 2 Z-score Z-score - - - 10090 M. musc... |
1680 31618756 pubmed Hoshino A (2019) 2-PMID31618756 19983 19983 Yes 3165 Delta Z scores Column Significance - High Throughput Phenotype Screen Pool Drug Exposure 10 Days OAR (1.0 μg/mL Oligomycin, 1.0 μg/mL Antimycin A and 100 nM Rotenone) - ~ 0.5 GECKO v2 (mouse) CRISPRn Knockout Cas9 C2C12 myoblast cell line protein... |
1681 31618756 pubmed Hoshino A (2019) 3-PMID31618756 19983 19983 Yes 2968 Delta Z scores Column Significance - High Throughput Phenotype Screen Pool Timecourse 10 Days - - ~ 0.5 GECKO v2 (mouse) CRISPRn Knockout Cas9 C2C12 myoblast cell line protein/peptide distribution 2 pos Z-score neg Z-score - - - 10090 M. musculus... |
1682 31618756 pubmed Hoshino A (2019) 4-PMID31618756 19983 19983 Yes 2684 Delta Z scores Column Significance - High Throughput Phenotype Screen Pool Drug Exposure 10 Days CCCP 13.0 µM ~ 0.5 GECKO v2 (mouse) CRISPRn Knockout Cas9 C2C12 myoblast cell line protein/peptide distribution 2 pos Z-score neg Z-score - - - 10090... |
1683 31618756 pubmed Hoshino A (2019) 5-PMID31618756 19983 19983 Yes 3008 Delta Z scores Column Significance - High Throughput Phenotype Screen Pool Drug Exposure 10 Days OAR (1.0 μg/mL Oligomycin, 1.0 μg/mL Antimycin A and 100 nM Rotenone) - ~ 0.5 GECKO v2 (mouse) CRISPRn Knockout Cas9 C2C12 myoblast cell line protein... |
1684 31618756 pubmed Hoshino A (2019) 6-PMID31618756 19983 19983 Yes 2902 Delta Z scores Column Significance - High Throughput Phenotype Screen Pool Drug Exposure 10 Days CCCP 13.0 µM ~ 0.5 GECKO v2 (mouse) CRISPRn Knockout Cas9 C2C12 myoblast cell line protein/peptide distribution 2 pos Z-score neg Z-score - - - 10090... |
1685 31618756 pubmed Hoshino A (2019) 7-PMID31618756 19983 19983 Yes 2943 Delta Z scores Column Significance - High Throughput Phenotype Screen Pool Drug Exposure 10 Days OAR (1.0 μg/mL Oligomycin, 1.0 μg/mL Antimycin A and 100 nM Rotenone) - ~ 0.5 GECKO v2 (mouse) CRISPRn Knockout Cas9 C2C12 myoblast cell line protein... |
1714 34016692 pubmed Norton JP (2021) 1-PMID34016692 764 20611 No 764 MaGeCK All Significant - High Throughput Negative Selection Pool Timecourse 12 Doublings - - < 1.0 GECKO v2 (mouse) CRISPRn Knockout Cas9 Rb1/Trp53-deleted SCLC mouse small cell lung cancer cell proliferation 3 MaGeCK Score FDR Log2FC - - 10090 M. mu... |
1716 34016692 pubmed Norton JP (2021) 3-PMID34016692 293 20611 No 293 MaGeCK All Significant - High Throughput Negative Selection Pool Timecourse 12 Doublings - - < 1.0 GECKO v2 (mouse) CRISPRn Knockout Cas9 MEF Embryonic Fibroblast Cell Line cell proliferation 3 MaGeCK Score FDR Log2FC - - 10090 M. musculus Authors sc... |
1717 34016692 pubmed Norton JP (2021) 4-PMID34016692 23 20611 No 23 MaGeCK All Significant - High Throughput Positive Selection Pool Timecourse 12 Doublings - - < 1.0 GECKO v2 (mouse) CRISPRn Knockout Cas9 MEF Embryonic Fibroblast Cell Line cell proliferation 3 MaGeCK Score FDR Log2FC - - 10090 M. musculus KO of the hi... |
1720 33562682 pubmed Sanghvi VR (2021) 1-PMID33562682 15829 15829 Yes 17 DESeq Score Significance Score.2 (p-Value) < 0.05 High Throughput Positive Selection Pool Drug Exposure - silvestrol 10.0 nM - mouse CRISPRn library (Yusa, 2013) CRISPRn Knockout Cas9 FL5.12 pro-B-lymphocyte response to chemicals 2 Log2FC p-Value ... |
1781 33953401 pubmed Griffin GK (2021) 1-PMID33953401 1057 1057 Yes 155 STARS Score Significance Score.2 (p-Value) < 0.05 High Throughput Negative Selection in vivo Implantation to Mouse Model 15 Days PD-1/CTLA-4 blockade - - CRISPRn Targeted Chromatin Regulator Library (Bernstein, 2021) CRISPRn Knockout Cas9 LL/2 (LLC... |
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