screen_file
string | organism
string | perturbation
string | gene
string | cell
string | phenotype
string | hit
int64 | benchmark_type
string | prompt
string | gene_context
string |
|---|---|---|---|---|---|---|---|---|---|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Lrr1
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Lrr1 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Lrr1 (leucine rich repeat protein 1)
Type: protein-coding
Summary: Predicted to be involved in intracellular signal transduction. Predicted to be located in nucleus. Orthologous to human LRR1 (leucine rich repeat protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: intracellular signal transduction, protein ubiquitination
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System, Metabolism of proteins, Neddylation, Post-translational protein modification
UniProt: D3YY91
Entrez ID: 69706
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Tmem126b
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Tmem126b in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Tmem126b (transmembrane protein 126B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial respiratory chain complex I assembly, mitochondrion organization, response to food; CC: membrane, mitochondrial membrane, mitochondrion
Pathways: Aerobic respiration and respiratory electron transport, Complex I biogenesis, Metabolism, Respiratory electron transport
UniProt: Q9D1R1
Entrez ID: 68472
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Tbca
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Tbca in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Tbca (tubulin cofactor A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: post-chaperonin tubulin folding pathway, protein folding, tubulin complex assembly; MF: beta-tubulin binding, tubulin binding; CC: cytoplasm, cytoskeleton, microtubule, microtubule cytoskeleton, nucleolus
Pathways:
UniProt: P48428
Entrez ID: 21371
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Gm2897
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Gm2897 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Gm2897 (predicted gene 2897)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: K7N6T7
Entrez ID: 100040671
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Chmp2a
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Chmp2a in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Chmp2a (charged multivesicular body protein 2A)
Type: protein-coding
Summary: Predicted to enable phosphatidylcholine binding activity and protein domain specific binding activity. Predicted to be involved in several processes, including mitotic nuclear division; regulation of cell cycle process; and vacuolar transport. Located in cytosol. Is expressed in several structures, including branchial arch; facial prominence; ganglia; gut; and limb bud. Orthologous to human CHMP2A (charged multivesicular body protein 2A). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: autophagosome maturation, autophagy, endosome transport via multivesicular body sorting pathway, establishment of protein localization, exit from mitosis, late endosome to lysosome transport, late endosome to vacuole transport, membrane fission, membrane invagination, midbody abscission, mitotic metaphase chromosome alignment, multivesicular body assembly, multivesicular body sorting pathway, multivesicular body-lysosome fusion, negative regulation of centriole elongation, nuclear membrane reassembly, nucleus organization, plasma membrane repair, positive regulation of exosomal secretion, protein homooligomerization, protein polymerization, protein transport, regulation of centrosome duplication, regulation of mitotic spindle assembly, ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway, vacuolar transport, vesicle fusion with vacuole, viral budding from plasma membrane, viral budding via host ESCRT complex, viral release from host cell; MF: phosphatidylcholine binding, protein binding, protein domain specific binding; CC: ESCRT III complex, amphisome membrane, autophagosome membrane, chromatin, cytoplasm, cytosol, endosome, kinetochore, kinetochore microtubule, late endosome membrane, lysosomal membrane, membrane, membrane coat, midbody, multivesicular body, multivesicular body membrane, nuclear envelope, nuclear pore, nucleus, plasma membrane
Pathways: Autophagy, Cell Cycle, Cell Cycle, Mitotic, Endocytosis - Mus musculus (mouse), Endosomal Sorting Complex Required For Transport (ESCRT), Lysosome Vesicle Biogenesis, M Phase, Macroautophagy, Membrane Trafficking, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Necroptosis - Mus musculus (mouse), Nuclear Envelope (NE) Reassembly, Programmed Cell Death, Pyroptosis, Regulated Necrosis, Sealing of the nuclear envelope (NE) by ESCRT-III, Vesicle-mediated transport, trans-Golgi Network Vesicle Budding
UniProt: Q9DB34
Entrez ID: 68953
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Ckap5
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Ckap5 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Ckap5 (cytoskeleton associated protein 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA transport, cell division, central nervous system myelin formation, centrosome cycle, centrosome duplication, cytoplasmic translation, dendritic spine maintenance, establishment or maintenance of microtubule cytoskeleton polarity, excitatory postsynaptic potential, habituation, locomotory behavior, long-term synaptic potentiation, mRNA localization resulting in post-transcriptional regulation of gene expression, microtubule polymerization, mitotic spindle organization, positive regulation of endocytosis, positive regulation of microtubule nucleation, protein-RNA complex assembly, protein-containing complex organization, spindle organization, visual learning; MF: microtubule binding, microtubule plus end polymerase, microtubule plus-end binding, ribonucleoprotein complex binding, tubulin binding; CC: centrosome, chromosome, chromosome, centromeric region, ciliary basal body, cilium, cytoplasm, cytoskeleton, dendrite, kinetochore, microtubule cytoskeleton, microtubule plus-end, mitotic spindle, neuronal ribonucleoprotein granule, nucleolus, perikaryon, plasma membrane, postsynapse, protein-containing complex, spindle, spindle pole
Pathways: AURKA Activation by TPX2, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Anchoring of the basal body to the plasma membrane, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Centrosome maturation, Cilium Assembly, EML4 and NUDC in mitotic spindle formation, G2/M Transition, Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, Mitotic Anaphase, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, Organelle biogenesis and maintenance, RHO GTPase Effectors, RHO GTPases Activate Formins, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Regulation of PLK1 Activity at G2/M Transition, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: A2AGT5
Entrez ID: 75786
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Sdhaf2
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Sdhaf2 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Sdhaf2 (succinate dehydrogenase complex assembly factor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial electron transport, succinate to ubiquinone, mitochondrial respiratory chain complex II assembly, negative regulation of canonical Wnt signaling pathway, negative regulation of epithelial to mesenchymal transition, protein-FAD linkage, tricarboxylic acid cycle; CC: cytosol, mitochondrial matrix, mitochondrion, nucleolus
Pathways: Aerobic respiration and respiratory electron transport, Citric acid cycle (TCA cycle), Maturation of TCA enzymes and regulation of TCA cycle, Metabolism
UniProt: Q8C6I2
Entrez ID: 66072
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Eif3f
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Eif3f in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Eif3f (eukaryotic translation initiation factor 3, subunit F)
Type: protein-coding
Summary: Enables cysteine-type deubiquitinase activity and translation initiation factor binding activity. Contributes to translation initiation factor activity. Involved in translational initiation. Part of eukaryotic translation initiation factor 3 complex, eIF3m. Is active in synapse. Is expressed in several structures, including central nervous system and genitourinary system. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 67. Orthologous to human EIF3F (eukaryotic translation initiation factor 3 subunit F). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: IRES-dependent viral translational initiation, cytoplasmic translational initiation, formation of cytoplasmic translation initiation complex, proteolysis, translation, translational initiation; MF: cysteine-type deubiquitinase activity, cysteine-type peptidase activity, deubiquitinase activity, hydrolase activity, identical protein binding, metal-dependent deubiquitinase activity, metallopeptidase activity, peptidase activity, protein binding, translation initiation factor activity, translation initiation factor binding; CC: cytoplasm, eukaryotic 43S preinitiation complex, eukaryotic 48S preinitiation complex, eukaryotic translation initiation factor 3 complex, eukaryotic translation initiation factor 3 complex, eIF3m, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Metabolism of proteins, Ribosomal scanning and start codon recognition, Translation, Translation initiation complex formation
UniProt: Q9DCH4
Entrez ID: 66085
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
2700062C07Rik
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of 2700062C07Rik in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: 2700062C07Rik (RIKEN cDNA 2700062C07 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA processing, biological_process; CC: cellular_component, nucleus, ribonuclease MRP complex
Pathways:
UniProt: Q5XFZ0
Entrez ID: 68046
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Slc25a19
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Slc25a19 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Slc25a19 (solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: deoxynucleotide transport, thiamine diphosphate biosynthetic process, thiamine pyrophosphate transmembrane transport, thiamine-containing compound metabolic process, transmembrane transport; MF: antiporter activity, deoxynucleotide transmembrane transporter activity, thiamine pyrophosphate transmembrane transporter activity, thiamine transmembrane transporter activity; CC: membrane, mitochondrial inner membrane, mitochondrial membrane, mitochondrion
Pathways: Metabolism, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, Vitamin B1 (thiamin) metabolism
UniProt: Q9DAM5
Entrez ID: 67283
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Mrpl53
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Mrpl53 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Mrpl53 (mitochondrial ribosomal protein L53)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Translation
UniProt: Q9D1H8
Entrez ID: 68499
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Eif3a
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Eif3a in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Eif3a (eukaryotic translation initiation factor 3, subunit A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: IRES-dependent viral translational initiation, cytoplasmic translational initiation, formation of cytoplasmic translation initiation complex, negative regulation of ERK1 and ERK2 cascade, translation, translation reinitiation, translational initiation, viral translational termination-reinitiation; MF: RNA binding, mRNA binding, protein binding, receptor tyrosine kinase binding, translation initiation factor activity; CC: centrosome, cytoplasm, cytoskeleton, cytosol, eukaryotic 43S preinitiation complex, eukaryotic 48S preinitiation complex, eukaryotic translation initiation factor 3 complex, eukaryotic translation initiation factor 3 complex, eIF3e, eukaryotic translation initiation factor 3 complex, eIF3m, microtubule, multi-eIF complex, nucleolus, nucleoplasm, nucleus, organelle, postsynaptic density
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Metabolism of proteins, Ribosomal scanning and start codon recognition, Translation, Translation initiation complex formation
UniProt: P23116
Entrez ID: 13669
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Mfn2
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Mfn2 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Mfn2 (mitofusin 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: aerobic respiration, apoptotic process, autophagy, blastocyst formation, camera-type eye morphogenesis, intracellular distribution of mitochondria, mitochondrial calcium ion homeostasis, mitochondrial fusion, mitochondrial membrane organization, mitochondrion localization, mitochondrion organization, negative regulation of Ras protein signal transduction, negative regulation of cardiac muscle cell apoptotic process, negative regulation of cell cycle, negative regulation of cell population proliferation, negative regulation of cell size, negative regulation of glial cell proliferation, negative regulation of mitochondrial fission, negative regulation of reactive oxygen species biosynthetic process, negative regulation of release of cytochrome c from mitochondria, negative regulation of sarcomere organization, negative regulation of smooth muscle cell proliferation, negative regulation of vascular associated smooth muscle cell proliferation, positive regulation of D-glucose import, positive regulation of cellular respiration, positive regulation of cold-induced thermogenesis, positive regulation of dendritic spine morphogenesis, positive regulation of estradiol secretion, positive regulation of gene expression, positive regulation of hydrogen peroxide biosynthetic process, positive regulation of insulin receptor signaling pathway, positive regulation of mitochondrial membrane potential, positive regulation of ovarian follicle development, positive regulation of progesterone secretion, positive regulation of reactive oxygen species biosynthetic process, positive regulation of vascular associated smooth muscle cell apoptotic process, positive regulation of vascular associated smooth muscle cell proliferation, protein localization to phagophore assembly site, protein targeting to mitochondrion, response to unfolded protein, type 2 mitophagy; MF: GTP binding, GTPase activity, GTPase binding, hydrolase activity, identical protein binding, nucleotide binding, protein binding, proteoglycan binding, small GTPase binding, ubiquitin protein ligase binding; CC: cytosol, membrane, microtubule cytoskeleton, mitochondrial outer membrane, mitochondrion
Pathways: Autophagy, Factors involved in megakaryocyte development and platelet production, Hemostasis, Macroautophagy, Miro GTPase Cycle, Mitophagy, Mitophagy - animal - Mus musculus (mouse), NOD-like receptor signaling pathway - Mus musculus (mouse), PINK1-PRKN Mediated Mitophagy, Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), RHOT2 GTPase cycle, Selective autophagy, Signal Transduction, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q80U63
Entrez ID: 170731
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Abce1
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Abce1 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Abce1 (ATP-binding cassette, sub-family E member 1)
Type: protein-coding
Summary: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the OABP subfamily. Alternatively referred to as the RNase L inhibitor, this protein functions to block the activity of ribonuclease L. Activation of ribonuclease L leads to inhibition of protein synthesis in the 2-5A/RNase L system, the central pathway for viral interferon action. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: CAT tailing, protein ufmylation, regulation of macromolecule metabolic process, regulation of translation, rescue of stalled ribosome, ribosome disassembly, ribosome-associated ubiquitin-dependent protein catabolic process, translation, translational initiation, translational termination; MF: 4 iron, 4 sulfur cluster binding, ATP binding, ATP hydrolysis activity, CTPase activity, GTPase activity, endoribonuclease inhibitor activity, hydrolase activity, iron ion binding, iron-sulfur cluster binding, metal ion binding, nucleotide binding, ribonucleoside triphosphate phosphatase activity, ribosomal small subunit binding; CC: cytoplasm, cytosol, cytosolic ribosome, mitochondrion
Pathways: Antiviral mechanism by IFN-stimulated genes, Cytokine Signaling in Immune system, Immune System, Interferon Signaling, Interferon alpha/beta signaling, Metabolism of proteins, OAS antiviral response, PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosome-associated quality control, Translation
UniProt: P61222
Entrez ID: 24015
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Cdkn2a
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Cdkn2a in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Cdkn2a (cyclin dependent kinase inhibitor 2A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: amyloid fibril formation, apoptotic process, apoptotic signaling pathway, autophagy of mitochondrion, cellular response to gamma radiation, cellular response to hydrogen peroxide, cellular senescence, epidermis development, glucose homeostasis, keratinocyte differentiation, keratinocyte proliferation, mitochondrial depolarization, negative regulation of B cell proliferation, negative regulation of DNA-templated transcription, negative regulation of cell cycle, negative regulation of cell growth, negative regulation of cell population proliferation, negative regulation of cell-matrix adhesion, negative regulation of hepatocyte proliferation, negative regulation of immature T cell proliferation in thymus, negative regulation of mammary gland epithelial cell proliferation, negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, negative regulation of protein localization to nucleolus, negative regulation of protein neddylation, negative regulation of proteolysis involved in protein catabolic process, negative regulation of ribosome biogenesis, negative regulation of transcription by RNA polymerase II, negative regulation of ubiquitin-dependent protein catabolic process, nuclear body organization, oncogene-induced cell senescence, positive regulation of DNA damage response, signal transduction by p53 class mediator, positive regulation of DNA-templated transcription, positive regulation of apoptotic process, positive regulation of apoptotic process involved in mammary gland involution, positive regulation of gene expression, positive regulation of protein localization to nucleus, positive regulation of protein sumoylation, positive regulation of signal transduction by p53 class mediator, positive regulation of transcription by RNA polymerase II, protein K63-linked ubiquitination, protein destabilization, protein localization to nucleolus, protein localization to nucleus, protein polyubiquitination, protein stabilization, rRNA processing, rRNA transcription, regulation of G1/S transition of mitotic cell cycle, regulation of cell cycle, regulation of gene expression, regulation of nucleocytoplasmic transport, regulation of protein export from nucleus, regulation of protein stability, regulation of protein targeting to mitochondrion, replicative senescence, response to xenobiotic stimulus, somatic stem cell division, somatic stem cell population maintenance; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor binding, MDM2/MDM4 family protein binding, NF-kappaB binding, RNA polymerase II-specific DNA-binding transcription factor binding, SUMO transferase activity, cyclin-dependent protein serine/threonine kinase inhibitor activity, disordered domain specific binding, ligase inhibitor activity, p53 binding, protein binding, protein kinase binding, ubiquitin ligase inhibitor activity, ubiquitin-protein transferase inhibitor activity; CC: cytoplasm, granular component, mitochondrion, nuclear body, nucleolus, nucleoplasm, nucleus, protein-containing complex, senescence-associated heterochromatin focus
Pathways: Bladder cancer - Mus musculus (mouse), Cell cycle - Mus musculus (mouse), Cellular senescence - Mus musculus (mouse), Chronic myeloid leukemia - Mus musculus (mouse), Cushing syndrome - Mus musculus (mouse), Glioma - Mus musculus (mouse), Hepatocellular carcinoma - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Melanoma - Mus musculus (mouse), MicroRNAs in cancer - Mus musculus (mouse), Non-small cell lung cancer - Mus musculus (mouse), Pancreatic cancer - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Viral carcinogenesis - Mus musculus (mouse), p53 signaling pathway - Mus musculus (mouse)
UniProt: P51480, Q64364
Entrez ID: 12578
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Cad
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Cad in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Cad (carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 'de novo' UMP biosynthetic process, 'de novo' pyrimidine nucleobase biosynthetic process, UDP biosynthetic process, UTP biosynthetic process, amino acid metabolic process, animal organ regeneration, cellular response to epidermal growth factor stimulus, cellular response to xenobiotic stimulus, citrulline biosynthetic process, female pregnancy, glutamine metabolic process, heart development, lactation, liver development, nucleobase-containing small molecule metabolic process, phosphate-containing compound metabolic process, pyrimidine nucleotide biosynthetic process, pyrimidine-containing compound biosynthetic process, response to amine, response to caffeine, response to cortisol, response to insulin, response to starvation, response to testosterone, xenobiotic metabolic process; MF: ATP binding, UTP binding, amino acid binding, aspartate carbamoyltransferase activity, carbamoyl-phosphate synthase (ammonia) activity, carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity, carboxyl- or carbamoyltransferase activity, catalytic activity, dihydroorotase activity, enzyme binding, glutaminase activity, hydrolase activity, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides, identical protein binding, ligase activity, metal ion binding, nucleotide binding, protein kinase activity, transferase activity, zinc ion binding; CC: cell projection, cytoplasm, cytosol, neuronal cell body, nuclear matrix, nucleus, protein-containing complex, terminal bouton
Pathways: Alanine, aspartate and glutamate metabolism - Mus musculus (mouse), Metabolism, Metabolism of nucleotides, Nucleotide biosynthesis, Pyrimidine biosynthesis, Pyrimidine metabolism - Mus musculus (mouse), pyrimidine ribonucleotides <i>de novo</i> biosynthesis, uridine-5,-phosphate biosynthesis
UniProt: B2RQC6
Entrez ID: 69719
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Psmd13
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Psmd13 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Psmd13 (proteasome (prosome, macropain) 26S subunit, non-ATPase, 13)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: meiosis I, ubiquitin-dependent protein catabolic process; MF: endopeptidase activity, structural molecule activity; CC: cytosol, nucleus, proteasome accessory complex, proteasome complex, proteasome regulatory particle, proteasome regulatory particle, lid subcomplex
Pathways: ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, AUF1 (hnRNP D0) binds and destabilizes mRNA, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Activation of NF-kappaB in B cells, Adaptive Immune System, Adherens junctions interactions, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Antigen processing-Cross presentation, Antigen processing: Ubiquitination & Proteasome degradation, Assembly of the pre-replicative complex, Asymmetric localization of PCP proteins, Autodegradation of Cdh1 by Cdh1:APC/C, Autodegradation of the E3 ubiquitin ligase COP1, Beta-catenin independent WNT signaling, C-type lectin receptors (CLRs), CDK-mediated phosphorylation and removal of Cdc6, CLEC7A (Dectin-1) signaling, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cellular response to chemical stress, Cellular response to hypoxia, Cellular responses to stimuli, Cellular responses to stress, Circadian clock, Class I MHC mediated antigen processing & presentation, Co-inhibition by PD-1, Cross-presentation of soluble exogenous antigens (endosomes), Cyclin A:Cdk2-associated events at S phase entry, Cyclin E associated events during G1/S transition , Cytokine Signaling in Immune system, DNA Replication, DNA Replication Pre-Initiation, Dectin-1 mediated noncanonical NF-kB signaling, Degradation of AXIN, Degradation of CDH1, Degradation of CRY and PER proteins, Degradation of DVL, Degradation of GLI1 by the proteasome, Degradation of beta-catenin by the destruction complex, Deubiquitination, Downstream TCR signaling, Downstream signaling events of B Cell Receptor (BCR), Epstein-Barr virus infection - Mus musculus (mouse), FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, FCERI mediated NF-kB activation, Fc epsilon receptor (FCERI) signaling, G1/S DNA Damage Checkpoints, G1/S Transition, G2/M Checkpoints, G2/M Transition, GLI3 is processed to GLI3R by the proteasome, GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2, GSK3B-mediated proteasomal degradation of PD-L1(CD274), Gene expression (Transcription), Generic Transcription Pathway, Hedgehog 'off' state, Hedgehog 'on' state, Hedgehog ligand biogenesis, Huntington disease - Mus musculus (mouse), Immune System, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, Intracellular signaling by second messengers, KEAP1-NFE2L2 pathway, M Phase, MAPK family signaling cascades, MAPK1/MAPK3 signaling, MAPK6/MAPK4 signaling, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of polyamines, Metabolism of proteins, Mitotic Anaphase, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, NIK-->noncanonical NF-kB signaling, Neddylation, Neutrophil degranulation, Nuclear events mediated by NFE2L2, Orc1 removal from chromatin, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, PCP/CE pathway, PIP3 activates AKT signaling, PTEN Regulation, Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Post-translational protein modification, Prion disease - Mus musculus (mouse), Proteasome - Mus musculus (mouse), Proteasome assembly, RAF/MAP kinase cascade, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of PTEN stability and activity, Regulation of RAS by GAPs, Regulation of RUNX2 expression and activity, Regulation of RUNX3 expression and activity, Regulation of T cell activation by CD28 family, Regulation of mRNA stability by proteins that bind AU-rich elements, Regulation of mitotic cell cycle, Regulation of ornithine decarboxylase (ODC), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, S Phase, SCF(Skp2)-mediated degradation of p27/p21, SPOP-mediated proteasomal degradation of PD-L1(CD274), Separation of Sister Chromatids, Signal Transduction, Signaling by Hedgehog, Signaling by Interleukins, Signaling by WNT, Signaling by the B Cell Receptor (BCR), Spinocerebellar ataxia - Mus musculus (mouse), Stabilization of p53, Switching of origins to a post-replicative state, Synthesis of DNA, TCF dependent signaling in response to WNT, TCR signaling, TNFR2 non-canonical NF-kB pathway, Targeted protein degradation, The role of GTSE1 in G2/M progression after G2 checkpoint, Transcriptional regulation by RUNX1, Transcriptional regulation by RUNX2, Transcriptional regulation by RUNX3, Translation, Transport of small molecules, UCH proteinases, Ub-specific processing proteases, Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, Ubiquitin-dependent degradation of Cyclin D, p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint, p53-Independent G1/S DNA Damage Checkpoint
UniProt: Q9WVJ2
Entrez ID: 23997
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Cep55
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Cep55 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Cep55 (centrosomal protein 55)
Type: protein-coding
Summary: Predicted to enable identical protein binding activity. Predicted to be involved in cranial skeletal system development; establishment of protein localization; and midbody abscission. Located in intercellular bridge and midbody. Is expressed in cerebral cortex ventricular layer; germ cell of testis; and ovary. Used to study Meckel syndrome. Human ortholog(s) of this gene implicated in multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia and hydranencephaly. Orthologous to human CEP55 (centrosomal protein 55). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cell division, cranial skeletal system development, establishment of protein localization, midbody abscission, mitotic cytokinesis, regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; MF: identical protein binding, protein binding; CC: Flemming body, centriole, centrosome, cleavage furrow, cytoplasm, cytoskeleton, intercellular bridge, midbody
Pathways:
UniProt: Q8BT07
Entrez ID: 74107
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Vps18
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Vps18 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Vps18 (VPS18 CORVET/HOPS core subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagy, endosome organization, endosome to lysosome transport, intracellular protein transport, lysosome organization, negative regulation of intracellular estrogen receptor signaling pathway, organelle fusion, protein transport, protein ubiquitination, regulation of synaptic vesicle exocytosis, symbiont entry into host cell, vesicle docking involved in exocytosis, vesicle-mediated transport; MF: actin binding, metal ion binding, protein binding, protein-macromolecule adaptor activity, syntaxin binding, ubiquitin protein ligase activity, zinc ion binding; CC: AP-3 adaptor complex, CORVET complex, HOPS complex, actin filament, autophagosome, clathrin-coated vesicle, cytoplasmic vesicle, early endosome, endomembrane system, endosome, glutamatergic synapse, late endosome, late endosome membrane, lysosomal membrane, lysosome, membrane, presynapse
Pathways: Salmonella infection - Mus musculus (mouse)
UniProt: Q8R307
Entrez ID: 228545
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Ttc14
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Ttc14 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Ttc14 (tetratricopeptide repeat domain 14)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: nucleic acid binding, protein binding
Pathways:
UniProt: Q9CSP9
Entrez ID: 67120
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Ptcd1
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Ptcd1 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Ptcd1 (pentatricopeptide repeat domain 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial translation, tRNA 3'-end processing, tRNA processing; MF: tRNA binding; CC: mitochondrial matrix, mitochondrion
Pathways:
UniProt: Q8C2E4
Entrez ID: 71799
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Snx7
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Snx7 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Snx7 (sorting nexin 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: endocytic recycling, mitophagy, piecemeal microautophagy of the nucleus, positive regulation of autophagosome assembly, protein transport, reticulophagy; MF: lipid binding, phosphatidylinositol binding, protein binding; CC: cytoplasm, early endosome, early endosome membrane, endosome, membrane, phagophore assembly site
Pathways:
UniProt: Q9CY18
Entrez ID: 76561
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Chmp3
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Chmp3 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Chmp3 (charged multivesicular body protein 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagosome maturation, autophagy, cell division, endosome to lysosome transport, endosome transport via multivesicular body sorting pathway, late endosome to lysosome transport, late endosome to vacuole transport, membrane fission, midbody abscission, mitotic metaphase chromosome alignment, multivesicular body assembly, multivesicular body sorting pathway, multivesicular body-lysosome fusion, nuclear membrane reassembly, nucleus organization, plasma membrane repair, positive regulation of cytokinesis, protein polymerization, protein transport, regulation of centrosome duplication, regulation of early endosome to late endosome transport, regulation of endosome size, regulation of mitotic spindle assembly, suppression of viral release by host, ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway, vacuolar transport, vesicle fusion with vacuole, viral budding from plasma membrane, viral budding via host ESCRT complex, viral release from host cell; MF: identical protein binding, molecular function inhibitor activity, phosphatidylcholine binding, phosphatidylinositol-4,5-bisphosphate binding, ubiquitin-specific protease binding; CC: ESCRT III complex, amphisome membrane, autophagosome membrane, cytoplasm, cytoplasmic vesicle, cytosol, early endosome, endosome, kinetochore, kinetochore microtubule, late endosome, late endosome membrane, lysosomal membrane, membrane, midbody, multivesicular body, multivesicular body membrane, nuclear pore, plasma membrane
Pathways: Autophagy, Cell Cycle, Cell Cycle, Mitotic, Endocytosis - Mus musculus (mouse), Endosomal Sorting Complex Required For Transport (ESCRT), M Phase, Macroautophagy, Membrane Trafficking, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Necroptosis - Mus musculus (mouse), Nuclear Envelope (NE) Reassembly, Programmed Cell Death, Pyroptosis, Regulated Necrosis, Sealing of the nuclear envelope (NE) by ESCRT-III, Vesicle-mediated transport
UniProt: Q9CQ10
Entrez ID: 66700
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Nudc
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Nudc in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Nudc (nudC nuclear distribution protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, establishment of organelle localization, mitotic metaphase chromosome alignment, mitotic spindle organization, nuclear migration, protein folding, response to peptide hormone; MF: protein binding, unfolded protein binding; CC: cytoplasm, cytoskeleton, cytosol, microtubule, midbody, mitotic spindle, nucleus, spindle
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, EML4 and NUDC in mitotic spindle formation, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, RHO GTPase Effectors, RHO GTPase cycle, RHO GTPases Activate Formins, RND2 GTPase cycle, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: O35685
Entrez ID: 18221
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Igf1r
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Igf1r in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Igf1r (insulin-like growth factor I receptor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adrenal gland development, amyloid-beta clearance, animal organ morphogenesis, axonogenesis, brain development, cell surface receptor protein tyrosine kinase signaling pathway, cellular response to amyloid-beta, cellular response to glucose stimulus, cellular response to insulin stimulus, cellular response to insulin-like growth factor stimulus, cellular response to transforming growth factor beta stimulus, cerebellum development, dendritic spine maintenance, epidermis development, establishment of cell polarity, estrous cycle, exocrine pancreas development, immune response, insulin receptor signaling pathway, insulin-like growth factor receptor signaling pathway, male sex determination, mammary gland development, negative regulation of MAPK cascade, negative regulation of apoptotic process, negative regulation of cholangiocyte apoptotic process, negative regulation of hepatocyte apoptotic process, negative regulation of muscle cell apoptotic process, negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, neuron projection development, positive regulation of DNA metabolic process, positive regulation of DNA-templated transcription, positive regulation of MAPK cascade, positive regulation of axon regeneration, positive regulation of cell cycle process, positive regulation of cell migration, positive regulation of cell population proliferation, positive regulation of cold-induced thermogenesis, positive regulation of cytokinesis, positive regulation of developmental growth, positive regulation of meiotic cell cycle, positive regulation of mitotic nuclear division, positive regulation of osteoblast proliferation, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of protein-containing complex disassembly, positive regulation of smooth muscle cell proliferation, positive regulation of steroid hormone biosynthetic process, postsynaptic modulation of chemical synaptic transmission, prostate gland epithelium morphogenesis, protein autophosphorylation, regulation of JNK cascade, response to L-glutamate, response to ethanol, transcytosis; MF: ATP binding, G-protein alpha-subunit binding, identical protein binding, insulin binding, insulin receptor activity, insulin receptor binding, insulin receptor substrate binding, insulin-like growth factor I binding, insulin-like growth factor binding, insulin-like growth factor receptor activity, kinase activity, nucleotide binding, phosphatidylinositol 3-kinase binding, protein binding, protein kinase activity, protein transporter activity, protein tyrosine kinase activity, protein-containing complex binding, structural molecule activity, transferase activity, transmembrane receptor protein tyrosine kinase activity; CC: T-tubule, alphav-beta3 integrin-IGF-1-IGF1R complex, axon, caveola, cilium, glutamatergic synapse, insulin receptor complex, membrane, neuronal cell body, nucleolus, plasma membrane, postsynapse, protein kinase complex, receptor complex
Pathways: AMPK signaling pathway - Mus musculus (mouse), Adherens junction - Mus musculus (mouse), Autophagy - animal - Mus musculus (mouse), Breast cancer - Mus musculus (mouse), ESR-mediated signaling, Endocytosis - Mus musculus (mouse), Extra-nuclear estrogen signaling, Focal adhesion - Mus musculus (mouse), FoxO signaling pathway - Mus musculus (mouse), Glioma - Mus musculus (mouse), HIF-1 signaling pathway - Mus musculus (mouse), Hepatocellular carcinoma - Mus musculus (mouse), IGF1R signaling cascade, IRS-related events triggered by IGF1R, Long-term depression - Mus musculus (mouse), Longevity regulating pathway - Mus musculus (mouse), Longevity regulating pathway - multiple species - Mus musculus (mouse), MAPK signaling pathway - Mus musculus (mouse), Melanoma - Mus musculus (mouse), Oocyte meiosis - Mus musculus (mouse), Ovarian steroidogenesis - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Progesterone-mediated oocyte maturation - Mus musculus (mouse), Prostate cancer - Mus musculus (mouse), Proteoglycans in cancer - Mus musculus (mouse), Rap1 signaling pathway - Mus musculus (mouse), Ras signaling pathway - Mus musculus (mouse), SHC-related events triggered by IGF1R, Signal Transduction, Signaling by Nuclear Receptors, Signaling by Receptor Tyrosine Kinases, Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), Signaling pathways regulating pluripotency of stem cells - Mus musculus (mouse), Transcriptional misregulation in cancer - Mus musculus (mouse), mTOR signaling pathway - Mus musculus (mouse)
UniProt: Q60751
Entrez ID: 16001
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Exosc3
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Exosc3 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Exosc3 (exosome component 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CUT catabolic process, DNA deamination, DNA metabolic process, RNA catabolic process, RNA processing, TRAMP-dependent tRNA surveillance pathway, U4 snRNA 3'-end processing, exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), gene expression, isotype switching, mRNA catabolic process, nuclear polyadenylation-dependent rRNA catabolic process, nuclear-transcribed mRNA catabolic process, poly(A)-dependent snoRNA 3'-end processing, positive regulation of isotype switching, rRNA processing, regulation of gene expression; MF: RNA binding, exonuclease activity, hydrolase activity, nuclease activity; CC: cytoplasm, cytoplasmic exosome (RNase complex), cytosol, euchromatin, exosome (RNase complex), nuclear exosome (RNase complex), nucleolar exosome (RNase complex), nucleolus, nucleoplasm, nucleus
Pathways: Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA, Deadenylation-dependent mRNA decay, KSRP (KHSRP) binds and destabilizes mRNA, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Nuclear RNA decay, RNA degradation - Mus musculus (mouse), Regulation of mRNA stability by proteins that bind AU-rich elements, Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA, mRNA decay by 3' to 5' exoribonuclease, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q7TQK4
Entrez ID: 66362
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Cenpp
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Cenpp in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Cenpp (centromere protein P)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CENP-A containing chromatin assembly, biological_process, chromosome segregation; CC: chromosome, chromosome, centromeric region, inner kinetochore, nucleolus, nucleoplasm, nucleus
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Chromosome Maintenance, Deposition of new CENPA-containing nucleosomes at the centromere, EML4 and NUDC in mitotic spindle formation, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, Nucleosome assembly, RHO GTPase Effectors, RHO GTPases Activate Formins, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q9CZ92
Entrez ID: 66336
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Rps20
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Rps20 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Rps20 (ribosomal protein S20)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Dec 2015].
Gene Ontology: BP: cytoplasmic translation, positive regulation of signal transduction by p53 class mediator, translation; MF: MDM2/MDM4 family protein binding, RNA binding, structural constituent of ribosome, ubiquitin ligase inhibitor activity; CC: cytoplasm, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, postsynapse, ribonucleoprotein complex, ribosome, small ribosomal subunit, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosomal scanning and start codon recognition, Ribosome - Mus musculus (mouse), Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, Translation initiation complex formation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P60867
Entrez ID: 67427
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Kti12
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Kti12 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Kti12 (KTI12 homolog, chromatin associated)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: ATP binding, molecular_function, nucleotide binding
Pathways:
UniProt: Q9D1R2
Entrez ID: 100087
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Srsf5
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Srsf5 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Srsf5 (serine and arginine-rich splicing factor 5)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. [provided by RefSeq, Nov 2016].
Gene Ontology: BP: RNA splicing, mRNA processing, positive regulation of RNA splicing, regulation of alternative mRNA splicing, via spliceosome, response to insulin, response to wounding; MF: RNA binding, RS domain binding, mRNA binding, nucleic acid binding, protein binding, protein kinase B binding; CC: cytosol, nuclear speck, nucleolus, nucleoplasm, nucleus
Pathways: Gene expression (Transcription), Herpes simplex virus 1 infection - Mus musculus (mouse), Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, Spliceosome - Mus musculus (mouse), Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA derived from an Intron-Containing Transcript, mRNA 3'-end processing, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: O35326
Entrez ID: 20384
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Gigyf1
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Gigyf1 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Gigyf1 (GRB10 interacting GYF protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: insulin-like growth factor receptor signaling pathway; CC: cytosol, protein-containing complex
Pathways:
UniProt: Q99MR1
Entrez ID: 57330
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Rrp36
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Rrp36 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Rrp36 (ribosomal RNA processing 36)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing, ribosomal small subunit biogenesis, ribosome biogenesis; CC: 90S preribosome, nucleolus, nucleoplasm, nucleus
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q3UFY0
Entrez ID: 224823
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Tomm70a
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Tomm70a in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Tomm70a (translocase of outer mitochondrial membrane 70A)
Type: protein-coding
Summary: Predicted to enable mitochondrion targeting sequence binding activity and molecular adaptor activity. Predicted to contribute to protein transmembrane transporter activity. Predicted to be involved in several processes, including cellular response to virus; protein targeting to mitochondrion; and regulation of defense response. Located in mitochondrion. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in congestive heart failure. Orthologous to human TOMM70 (translocase of outer mitochondrial membrane 70). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: activation of innate immune response, antiviral innate immune response, cellular response to virus, mRNA transcription, negative regulation of cell growth involved in cardiac muscle cell development, positive regulation of defense response to virus by host, positive regulation of interferon-beta production, positive regulation of protein targeting to mitochondrion, protein import into mitochondrial matrix, protein insertion into mitochondrial inner membrane, protein targeting to mitochondrion, regulation of apoptotic process, response to thyroxine; MF: mitochondrion targeting sequence binding, molecular adaptor activity, protein binding, protein transmembrane transporter activity, protein-macromolecule adaptor activity; CC: membrane, mitochondrial membrane, mitochondrial outer membrane, mitochondrion
Pathways: Autophagy, DDX58/IFIH1-mediated induction of interferon-alpha/beta, Deubiquitination, Immune System, Innate Immune System, Macroautophagy, Metabolism of proteins, Mitophagy, PINK1-PRKN Mediated Mitophagy, Post-translational protein modification, Selective autophagy, Ub-specific processing proteases
UniProt: Q9CZW5
Entrez ID: 28185
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Pik3c2a
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Pik3c2a in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Pik3c2a (phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagosome organization, cell migration, cellular response to starvation, endocytosis, exocytosis, lipid metabolic process, macroautophagy, negative regulation of zinc ion transmembrane transport, phosphatidylinositol 3-kinase/protein kinase B signal transduction, phosphatidylinositol phosphate biosynthetic process, phosphatidylinositol-3-phosphate biosynthetic process, phosphatidylinositol-mediated signaling, positive regulation of autophagy, positive regulation of cell migration involved in sprouting angiogenesis; MF: 1-phosphatidylinositol-3-kinase activity, 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity, 1-phosphatidylinositol-4-phosphate 3-kinase activity, ATP binding, clathrin binding, kinase activity, nucleotide binding, phosphatidylinositol binding, transferase activity; CC: Golgi apparatus, clathrin-coated vesicle, cytoplasm, cytoplasmic vesicle, cytosol, membrane, nucleoplasm, nucleus, plasma membrane, trans-Golgi network, vesicle
Pathways: 3-phosphoinositide biosynthesis, Clathrin-mediated endocytosis, Golgi Associated Vesicle Biogenesis, Inositol phosphate metabolism - Mus musculus (mouse), Membrane Trafficking, Metabolism, Metabolism of lipids, PI Metabolism, PIP metabolism, Phosphatidylinositol signaling system - Mus musculus (mouse), Phospholipid metabolism, Salmonella infection - Mus musculus (mouse), Synthesis of PIPs at the Golgi membrane, Synthesis of PIPs at the early endosome membrane, Synthesis of PIPs at the late endosome membrane, Synthesis of PIPs at the plasma membrane, Vesicle-mediated transport, trans-Golgi Network Vesicle Budding
UniProt: Q61194
Entrez ID: 18704
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Sdhc
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Sdhc in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Sdhc (succinate dehydrogenase complex, subunit C, integral membrane protein)
Type: protein-coding
Summary: Predicted to enable heme binding activity. Predicted to be involved in mitochondrial electron transport, succinate to ubiquinone. Located in mitochondrion. Part of respiratory chain complex II (succinate dehydrogenase). Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and sensory organ. Used to study Leigh disease. Human ortholog(s) of this gene implicated in Carney-Stratakis syndrome; gastrointestinal stromal tumor; lung non-small cell carcinoma; and paraganglioma. Orthologous to human SDHC (succinate dehydrogenase complex subunit C). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: mitochondrial electron transport, succinate to ubiquinone, proton motive force-driven mitochondrial ATP synthesis, tricarboxylic acid cycle; MF: electron transfer activity, heme binding, metal ion binding; CC: membrane, mitochondrial inner membrane, mitochondrion, respiratory chain complex II (succinate dehydrogenase)
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Citrate cycle (TCA cycle) - Mus musculus (mouse), Citric acid cycle (TCA cycle), Diabetic cardiomyopathy - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Maturation of TCA enzymes and regulation of TCA cycle, Metabolism, Non-alcoholic fatty liver disease - Mus musculus (mouse), Oxidative phosphorylation - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), TCA cycle, TCA cycle variation III (eukaryotic), Thermogenesis - Mus musculus (mouse), aerobic respiration -- electron donor II, aerobic respiration -- electron donors reaction list
UniProt: Q9CZB0
Entrez ID: 66052
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Fus
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Fus in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Fus (fused in sarcoma)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, amyloid fibril formation, gene expression, mRNA stabilization, membraneless organelle assembly, positive regulation of DNA-templated transcription, positive regulation of double-strand break repair via homologous recombination, protein homooligomerization, regulation of DNA-templated transcription, regulation of RNA splicing, regulation of transcription by RNA polymerase II; MF: DNA binding, RNA binding, chromatin binding, identical protein binding, ionotropic glutamate receptor binding, mRNA 3'-UTR binding, metal ion binding, molecular condensate scaffold activity, myosin V binding, nuclear estrogen receptor binding, nuclear retinoid X receptor binding, nuclear thyroid hormone receptor binding, nucleic acid binding, protein binding, transcription coactivator activity, transcription coregulator activity, zinc ion binding; CC: GABA-ergic synapse, cytoplasm, dendrite, dendritic spine, dendritic spine head, glutamatergic synapse, neuronal cell body, nucleoplasm, nucleus, perikaryon, perinuclear region of cytoplasm, postsynaptic cytosol, presynaptic cytosol
Pathways: Amyotrophic lateral sclerosis - Mus musculus (mouse), Metabolism of RNA, Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Mus musculus (mouse), Transcriptional misregulation in cancer - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway, mRNA surveillance pathway - Mus musculus (mouse)
UniProt: P56959
Entrez ID: 233908
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Acly
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Acly in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Acly (ATP citrate lyase)
Type: protein-coding
Summary: Enables ATP citrate synthase activity. Predicted to be involved in acetyl-CoA biosynthetic process and carboxylic acid metabolic process. Located in mitochondrion. Is active in cytosol. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human ACLY (ATP citrate lyase). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: acetyl-CoA biosynthetic process, acetyl-CoA metabolic process, acyl-CoA biosynthetic process, citrate metabolic process, fatty acid biosynthetic process, lipid biosynthetic process, lipid metabolic process, malonyl-CoA biosynthetic process, negative regulation of ferroptosis, oxaloacetate metabolic process; MF: ATP binding, ATP citrate synthase activity, acyltransferase activity, acyl groups converted into alkyl on transfer, catalytic activity, metal ion binding, nucleotide binding, protein binding, transferase activity; CC: ciliary basal body, cytoplasm, cytosol, mitochondrion, nucleoplasm
Pathways: Citrate cycle (TCA cycle) - Mus musculus (mouse), Fatty acid metabolism, Fatty acyl-CoA biosynthesis, Immune System, Innate Immune System, Metabolism, Metabolism of lipids, Neutrophil degranulation, acetyl-CoA biosynthesis (from citrate), superpathway of acetyl-CoA biosynthesis
UniProt: Q91V92
Entrez ID: 104112
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Rapgef1
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Rapgef1 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Rapgef1 (Rap guanine nucleotide exchange factor (GEF) 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Rap protein signal transduction, Ras protein signal transduction, blood vessel development, cell-cell adhesion, cellular response to cAMP, cellular response to nerve growth factor stimulus, establishment of endothelial barrier, negative regulation of ERK1 and ERK2 cascade, negative regulation of Ras protein signal transduction, negative regulation of canonical Wnt signaling pathway, negative regulation of neural precursor cell proliferation, negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, nerve growth factor signaling pathway, platelet-derived growth factor receptor signaling pathway, positive regulation of ERK1 and ERK2 cascade, positive regulation of Fc receptor mediated stimulatory signaling pathway, positive regulation of neuron projection development, positive regulation of phagocytosis, regulation of JNK cascade, regulation of cell junction assembly, small GTPase-mediated signal transduction; MF: guanyl-nucleotide exchange factor activity, protein binding; CC: cytoplasm, early endosome, perinuclear region of cytoplasm, phagocytic vesicle membrane, plasma membrane, protein-containing complex
Pathways: Cytokine Signaling in Immune system, Downstream signal transduction, Erythropoietin activates RAS, Focal adhesion - Mus musculus (mouse), Frs2-mediated activation, Immune System, Insulin signaling pathway - Mus musculus (mouse), Interleukin-3, Interleukin-5 and GM-CSF signaling, MET activates RAP1 and RAC1, MET promotes cell motility, Neurotrophin signaling pathway - Mus musculus (mouse), Prolonged ERK activation events, RAC3 GTPase cycle, RHO GTPase cycle, Rap1 signaling pathway - Mus musculus (mouse), Regulation of signaling by CBL, Renal cell carcinoma - Mus musculus (mouse), Signal Transduction, Signaling by Erythropoietin, Signaling by Interleukins, Signaling by MET, Signaling by NTRK1 (TRKA), Signaling by NTRKs, Signaling by PDGF, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signalling to ERKs
UniProt: A1L338, Q91ZZ2, Q3UHC1, Q3UGX8, A0A5F8MPI9, Q8C5V7, F6ZDE5
Entrez ID: 107746
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Pnpt1
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Pnpt1 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Pnpt1 (polyribonucleotide nucleotidyltransferase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA catabolic process, RNA import into mitochondrion, RNA processing, cellular response to interferon-beta, cellular response to oxidative stress, liver regeneration, mRNA catabolic process, mRNA processing, mitochondrial RNA 3'-end processing, mitochondrial RNA 5'-end processing, mitochondrial RNA catabolic process, mitochondrial mRNA catabolic process, mitochondrial mRNA polyadenylation, mitochondrion organization, nuclear polyadenylation-dependent mRNA catabolic process, positive regulation of mRNA catabolic process, positive regulation of miRNA catabolic process, positive regulation of mitochondrial RNA catabolic process, protein homooligomerization, protein homotrimerization, rRNA import into mitochondrion, regulation of cellular respiration, regulation of cellular senescence, response to cAMP, response to growth hormone; MF: 3'-5'-RNA exonuclease activity, RNA binding, exonuclease activity, hydrolase activity, identical protein binding, miRNA binding, nuclease activity, nucleic acid binding, nucleotidyltransferase activity, poly(G) binding, poly(U) RNA binding, polyribonucleotide nucleotidyltransferase activity, transferase activity; CC: cytoplasm, cytosol, endoplasmic reticulum membrane, membrane, mitochondrial degradosome, mitochondrial intermembrane space, mitochondrial matrix, mitochondrion, ribosome
Pathways: RNA degradation - Mus musculus (mouse)
UniProt: Q8K1R3
Entrez ID: 71701
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Bri3
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Bri3 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Bri3 (brain protein I3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: identical protein binding; CC: cytoplasm, lysosomal membrane, lysosome, membrane, perinuclear region of cytoplasm
Pathways: Immune System, Innate Immune System, Neutrophil degranulation
UniProt: P28662
Entrez ID: 55950
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Nsun4
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Nsun4 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Nsun4 (NOL1/NOP2/Sun domain family, member 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial RNA catabolic process, mitochondrial RNA modification, rRNA methylation, tRNA methylation; MF: RNA methyltransferase activity, mRNA (cytidine-5-)-methyltransferase activity, rRNA (cytosine-C5-)-methyltransferase activity, rRNA methyltransferase activity, tRNA (cytidine-5-)-methyltransferase activity, tRNA binding; CC: cytoplasm, mitochondrial matrix, mitochondrion, nucleus
Pathways:
UniProt: C4P6S0, Q9CZ57
Entrez ID: 72181
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Bcl7a
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Bcl7a in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Bcl7a (B cell CLL/lymphoma 7A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin remodeling, motor behavior, negative regulation of cell differentiation, neuron projection arborization, positive regulation of cell population proliferation, positive regulation of double-strand break repair, positive regulation of stem cell population maintenance, regulation of G0 to G1 transition, regulation of G1/S transition of mitotic cell cycle, regulation of mitotic metaphase/anaphase transition, regulation of nucleotide-excision repair, regulation of transcription by RNA polymerase II; CC: GBAF complex, SWI/SNF complex, chromatin, nucleoplasm
Pathways: ATP-dependent chromatin remodelers, Chromatin organization, Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF), Formation of the canonical BAF (cBAF) complex, Formation of the embryonic stem cell BAF (esBAF) complex, Formation of the non-canonical BAF (ncBAF) complex, Formation of the polybromo-BAF (pBAF) complex, SWI/SNF chromatin remodelers
UniProt: Q9CXE2
Entrez ID: 77045
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Gm15127
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Gm15127 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Gm15127 (predicted gene 15127)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: E9Q1L3, B1AVZ5
Entrez ID: 434866
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Med13
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Med13 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Med13 (mediator complex subunit 13)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cholesterol homeostasis, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, positive regulation of transcription initiation by RNA polymerase II, regulation of transcription by RNA polymerase II, triglyceride homeostasis; MF: nuclear thyroid hormone receptor binding, transcription coactivator activity, transcription coregulator activity; CC: CKM complex, mediator complex, nucleoplasm, nucleus
Pathways: Thyroid hormone signaling pathway - Mus musculus (mouse)
UniProt: Q5SWW4
Entrez ID: 327987
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Mbip
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Mbip in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Mbip (MAP3K12 binding inhibitory protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of transcription by RNA polymerase II, positive regulation of JNK cascade, positive regulation of gene expression, regulation of DNA-templated transcription, regulation of cell cycle, regulation of cell division, regulation of embryonic development, regulation of transcription by RNA polymerase II; MF: identical protein binding, protein binding, protein kinase inhibitor activity; CC: ATAC complex, cytoplasm, cytosol, mitotic spindle, nucleolus, nucleoplasm, nucleus
Pathways: Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of gene expression, Formation of WDR5-containing histone-modifying complexes, Gene expression (Transcription)
UniProt: Q99LQ1
Entrez ID: 217588
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Sptlc1
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Sptlc1 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Sptlc1 (serine palmitoyltransferase, long chain base subunit 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ceramide biosynthetic process, lipid metabolic process, positive regulation of lipophagy, regulation of fat cell apoptotic process, sphinganine biosynthetic process, sphingolipid biosynthetic process, sphingolipid metabolic process, sphingomyelin biosynthetic process, sphingosine biosynthetic process; MF: acyltransferase activity, protein binding, pyridoxal phosphate binding, serine C-palmitoyltransferase activity, transferase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, serine palmitoyltransferase complex
Pathways: Metabolism, Metabolism of lipids, Sphingolipid de novo biosynthesis, Sphingolipid metabolism, Sphingolipid metabolism - Mus musculus (mouse), Sphingolipid signaling pathway - Mus musculus (mouse), ceramide biosynthesis
UniProt: O35704
Entrez ID: 268656
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Tmprss4
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Tmprss4 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Tmprss4 (transmembrane protease, serine 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of growth rate, positive regulation of viral entry into host cell, protein processing, proteolysis, regulation of gene expression, response to wounding; MF: hydrolase activity, peptidase activity, serine-type endopeptidase activity, serine-type peptidase activity; CC: extracellular region, extracellular space, membrane, plasma membrane, secretory granule
Pathways: Influenza A - Mus musculus (mouse)
UniProt: Q8VCA5
Entrez ID: 214523
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Lig3
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Lig3 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Lig3 (ligase III, DNA, ATP-dependent)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA biosynthetic process, DNA damage response, DNA recombination, DNA repair, DNA replication, base-excision repair, cell division, double-strand break repair, double-strand break repair via alternative nonhomologous end joining, double-strand break repair via nonhomologous end joining, lagging strand elongation, mitochondrial DNA repair, mitochondrion organization, negative regulation of DNA metabolic process, negative regulation of DNA recombination, negative regulation of mitochondrial DNA replication; MF: ATP binding, DNA binding, DNA ligase (ATP) activity, DNA ligase activity, ligase activity, metal ion binding, nucleotide binding, protein binding, zinc ion binding; CC: DNA ligase III-XRCC1 complex, condensed nuclear chromosome, mitochondrion, nuclear lumen, nucleoplasm, nucleus, synaptonemal complex
Pathways: Base excision repair - Mus musculus (mouse)
UniProt: Q80ZH7, Q3UC82, B1AT03, Q3TJN5, G3UYI8
Entrez ID: 16882
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Scd3
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Scd3 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Scd3 (stearoyl-coenzyme A desaturase 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: fatty acid biosynthetic process, fatty acid metabolic process, lipid metabolic process, monounsaturated fatty acid biosynthetic process, response to fatty acid, unsaturated fatty acid biosynthetic process; MF: acyl-CoA desaturase activity, iron ion binding, metal ion binding, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water, palmitoyl-CoA 9-desaturase activity, stearoyl-CoA 9-desaturase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, nucleolus
Pathways: AMPK signaling pathway - Mus musculus (mouse), Alcoholic liver disease - Mus musculus (mouse), Biosynthesis of unsaturated fatty acids - Mus musculus (mouse), PPAR signaling pathway - Mus musculus (mouse)
UniProt: Q99PL7
Entrez ID: 30049
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Atp1b3
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Atp1b3 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Atp1b3 (ATPase, Na+/K+ transporting, beta 3 polypeptide)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intracellular potassium ion homeostasis, intracellular sodium ion homeostasis, membrane repolarization, metal ion transport, monoatomic ion transport, positive regulation of potassium ion import across plasma membrane, positive regulation of sodium ion export across plasma membrane, potassium ion import across plasma membrane, potassium ion transmembrane transport, potassium ion transport, protein localization to plasma membrane, protein stabilization, sodium ion export across plasma membrane, sodium ion transmembrane transport, sodium ion transport; MF: ATPase activator activity, ATPase binding, P-type sodium:potassium-exchanging transporter activity, protein binding, protein-macromolecule adaptor activity, transporter activator activity; CC: apical plasma membrane, basolateral plasma membrane, caveola, cytoplasm, melanosome, membrane, plasma membrane, sodium:potassium-exchanging ATPase complex, sperm flagellum
Pathways: Adrenergic signaling in cardiomyocytes - Mus musculus (mouse), Aldosterone synthesis and secretion - Mus musculus (mouse), Aldosterone-regulated sodium reabsorption - Mus musculus (mouse), Basigin interactions, Bile secretion - Mus musculus (mouse), Carbohydrate digestion and absorption - Mus musculus (mouse), Cardiac conduction, Cardiac muscle contraction - Mus musculus (mouse), Cell surface interactions at the vascular wall, Endocrine and other factor-regulated calcium reabsorption - Mus musculus (mouse), Gastric acid secretion - Mus musculus (mouse), Hemostasis, Insulin secretion - Mus musculus (mouse), Ion channel transport, Ion homeostasis, Ion transport by P-type ATPases, Mineral absorption - Mus musculus (mouse), Muscle contraction, Pancreatic secretion - Mus musculus (mouse), Protein digestion and absorption - Mus musculus (mouse), Proximal tubule bicarbonate reclamation - Mus musculus (mouse), Salivary secretion - Mus musculus (mouse), Thyroid hormone signaling pathway - Mus musculus (mouse), Thyroid hormone synthesis - Mus musculus (mouse), Transport of small molecules, cAMP signaling pathway - Mus musculus (mouse), cGMP-PKG signaling pathway - Mus musculus (mouse)
UniProt: P97370
Entrez ID: 11933
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Dhx16
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Dhx16 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Dhx16 (DEAH-box helicase 16)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, antiviral innate immune response, immune system process, innate immune response, mRNA processing, mRNA splicing, via spliceosome; MF: ATP binding, ATP-dependent activity, acting on RNA, RNA binding, RNA helicase activity, helicase activity, hydrolase activity, molecular adaptor activity, nucleic acid binding, nucleotide binding, pattern recognition receptor activity, ubiquitin binding; CC: U2-type precatalytic spliceosome, cytoplasm, nucleoplasm, nucleus, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q9CRI3, Q921Y1, G3X8X0, Q05BH3, G3UXT5
Entrez ID: 69192
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Plrg1
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Plrg1 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Plrg1 (pleiotropic regulator 1)
Type: protein-coding
Summary: Acts upstream of or within positive regulation of G1/S transition of mitotic cell cycle and protein localization to nucleus. Predicted to be located in fibrillar center; nuclear membrane; and nuclear speck. Predicted to be part of DNA replication factor A complex; Prp19 complex; and U2-type catalytic step 2 spliceosome. Is expressed in several structures, including alimentary system; branchial arch; genitourinary system; hemolymphoid system; and sensory organ. Orthologous to human PLRG1 (pleiotropic regulator 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: RNA splicing, mRNA processing, mRNA splicing, via spliceosome, positive regulation of G1/S transition of mitotic cell cycle, protein localization to nucleus; CC: DNA replication factor A complex, Prp19 complex, U2-type catalytic step 2 spliceosome, catalytic step 2 spliceosome, fibrillar center, nuclear membrane, nuclear speck, nucleoplasm, nucleus, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q922V4
Entrez ID: 53317
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Ifna12
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Ifna12 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Ifna12 (interferon alpha 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell activation involved in immune response, T cell activation involved in immune response, adaptive immune response, defense response, defense response to virus, humoral immune response, natural killer cell activation involved in immune response, response to exogenous dsRNA, type I interferon-mediated signaling pathway; MF: cytokine activity, cytokine receptor binding, type I interferon receptor binding; CC: extracellular region, extracellular space
Pathways: Alcoholic liver disease - Mus musculus (mouse), Autoimmune thyroid disease - Mus musculus (mouse), Coronavirus disease - COVID-19 - Mus musculus (mouse), Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Mus musculus (mouse), Cytosolic DNA-sensing pathway - Mus musculus (mouse), Epstein-Barr virus infection - Mus musculus (mouse), Hepatitis B - Mus musculus (mouse), Hepatitis C - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Immune System, Influenza A - Mus musculus (mouse), Interferon Signaling, Interferon alpha/beta signaling, JAK-STAT signaling pathway - Mus musculus (mouse), Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), Measles - Mus musculus (mouse), NOD-like receptor signaling pathway - Mus musculus (mouse), Natural killer cell mediated cytotoxicity - Mus musculus (mouse), Necroptosis - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), RIG-I-like receptor signaling pathway - Mus musculus (mouse), Regulation of IFNA/IFNB signaling, Toll-like receptor signaling pathway - Mus musculus (mouse), Tuberculosis - Mus musculus (mouse)
UniProt: Q80SS5
Entrez ID: 242519
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Edc3
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Edc3 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Edc3 (enhancer of mRNA decapping 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: P-body assembly, deadenylation-independent decapping of nuclear-transcribed mRNA; MF: RNA binding, identical protein binding, mRNA binding; CC: P-body, cytoplasm, cytoplasmic ribonucleoprotein granule
Pathways: Deadenylation-dependent mRNA decay, Metabolism of RNA, RNA degradation - Mus musculus (mouse), mRNA decay by 5' to 3' exoribonuclease
UniProt: Q8K2D3
Entrez ID: 353190
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Cmpk1
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Cmpk1 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Cmpk1 (cytidine/uridine monophosphate kinase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 'de novo' pyrimidine nucleobase biosynthetic process, CDP biosynthetic process, UDP biosynthetic process, dCDP biosynthetic process, dUDP biosynthetic process, nucleobase-containing compound metabolic process, nucleoside monophosphate phosphorylation, pyrimidine nucleotide biosynthetic process, pyrimidine-containing compound biosynthetic process; MF: ATP binding, CMP kinase activity, UMP kinase activity, dCMP kinase activity, dUMP kinase activity, kinase activity, nucleobase-containing compound kinase activity, nucleoside diphosphate kinase activity, nucleoside monophosphate kinase activity, nucleotide binding, phosphotransferase activity, phosphate group as acceptor, transferase activity; CC: cytoplasm, nucleolus, nucleoplasm, nucleus
Pathways: Drug metabolism - other enzymes - Mus musculus (mouse), Interconversion of nucleotide di- and triphosphates, Metabolism, Metabolism of nucleotides, Pyrimidine metabolism - Mus musculus (mouse)
UniProt: Q9DBP5
Entrez ID: 66588
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Cdh2
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Cdh2 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Cdh2 (cadherin 2)
Type: protein-coding
Summary: This gene encodes a member of the cadherin family of calcium-dependent glycoproteins that mediate cell adhesion. The encoded preproprotein undergoes proteolytic processing to generate a mature protein. Mice lacking the encoded protein exhibit severe developmental defects resulting in embryonic death. [provided by RefSeq, Oct 2015].
Gene Ontology: BP: adherens junction organization, blood vessel morphogenesis, brain morphogenesis, calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules, cell adhesion, cell migration, cell morphogenesis, cell-cell adhesion, cell-cell adhesion mediated by cadherin, cell-cell junction assembly, cerebral cortex development, glial cell differentiation, heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules, homeostasis of number of cells, homophilic cell adhesion via plasma membrane adhesion molecules, mesenchymal cell migration, modulation of chemical synaptic transmission, negative regulation of canonical Wnt signaling pathway, neural crest cell development, neuroepithelial cell differentiation, neuroligin clustering involved in postsynaptic membrane assembly, neuronal stem cell population maintenance, positive regulation of MAPK cascade, positive regulation of synaptic vesicle clustering, radial glial cell differentiation, regulation of Rho protein signal transduction, regulation of axonogenesis, regulation of myelination, regulation of oligodendrocyte progenitor proliferation, regulation of postsynaptic density protein 95 clustering, regulation of protein localization, striated muscle cell differentiation, synapse assembly, synaptic vesicle clustering, telencephalon development, type B pancreatic cell development; MF: RNA binding, alpha-catenin binding, beta-catenin binding, cadherin binding, calcium ion binding, enzyme binding, gamma-catenin binding, identical protein binding, metal ion binding, nitric-oxide synthase binding, protein binding, protein kinase binding, protein phosphatase binding, protein tyrosine kinase binding, protein-containing complex binding; CC: T-tubule, adherens junction, anchoring junction, apical part of cell, apical plasma membrane, apicolateral plasma membrane, basolateral plasma membrane, catenin complex, cell junction, cell surface, cell-cell junction, cortical actin cytoskeleton, cytoplasm, desmosome, fascia adherens, glutamatergic synapse, intercalated disc, lamellipodium, membrane, neuron projection, plasma membrane, plasma membrane raft, presynapse, protein-containing complex, sarcolemma, synapse
Pathways: Adherens junctions interactions, Arrhythmogenic right ventricular cardiomyopathy - Mus musculus (mouse), Cell adhesion molecules - Mus musculus (mouse), Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Developmental Biology, Metabolism of proteins, Myogenesis, Post-translational protein modification, Post-translational protein phosphorylation, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
UniProt: P15116
Entrez ID: 12558
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Mrpl45
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Mrpl45 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Mrpl45 (mitochondrial ribosomal protein L45)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial translation; MF: structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Translation
UniProt: Q9D0Q7
Entrez ID: 67036
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Gstcd
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Gstcd in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Gstcd (glutathione S-transferase, C-terminal domain containing)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, respiratory system development, response to lipopolysaccharide; MF: molecular_function, protein binding; CC: cytoplasm
Pathways:
UniProt: Q5RL51
Entrez ID: 67553
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Actr10
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Actr10 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Actr10 (ARP10 actin-related protein 10)
Type: protein-coding
Summary: Acts upstream of or within microtubule-based movement. Part of dynactin complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human ACTR10 (actin related protein 10). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: microtubule-based movement, retrograde axonal transport of mitochondrion; CC: axon cytoplasm, cytoplasm, cytoskeleton, dynactin complex
Pathways: Adaptive Immune System, Amyotrophic lateral sclerosis - Mus musculus (mouse), Asparagine N-linked glycosylation, COPI-independent Golgi-to-ER retrograde traffic, COPI-mediated anterograde transport, Cellular responses to stimuli, Cellular responses to stress, ER to Golgi Anterograde Transport, Golgi-to-ER retrograde transport, HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand, Huntington disease - Mus musculus (mouse), Immune System, Innate Immune System, Intra-Golgi and retrograde Golgi-to-ER traffic, MHC class II antigen presentation, Membrane Trafficking, Metabolism of proteins, Neutrophil degranulation, Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Post-translational protein modification, Salmonella infection - Mus musculus (mouse), Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: Q9QZB7
Entrez ID: 56444
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Prpf18
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Prpf18 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Prpf18 (pre-mRNA processing factor 18)
Type: protein-coding
Summary: Predicted to be involved in generation of catalytic spliceosome for second transesterification step and negative regulation of protein metabolic process. Predicted to be located in nuclear speck. Predicted to be part of U2-type post-spliceosomal complex; U4/U6 x U5 tri-snRNP complex; and U5 snRNP. Is expressed in several structures, including adipose tissue; alimentary system; central nervous system; genitourinary system; and sensory organ. Orthologous to human PRPF18 (pre-mRNA processing factor 18). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: RNA splicing, generation of catalytic spliceosome for second transesterification step, mRNA processing, negative regulation of protein metabolic process; CC: U2-type post-spliceosomal complex, U4/U6 x U5 tri-snRNP complex, U5 snRNP, nuclear speck, nucleus, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q8BM39
Entrez ID: 67229
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Pkm
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Pkm in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Pkm (pyruvate kinase, muscle)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: canonical glycolysis, cellular response to insulin stimulus, chromatin remodeling, glucose metabolic process, glycolytic process, positive regulation of cytoplasmic translation, positive regulation of sprouting angiogenesis, positive regulation of transcription by RNA polymerase II, programmed cell death, regulation of translation; MF: ADP binding, ATP binding, catalytic activity, histone H3T11 kinase activity, identical protein binding, kinase activity, mRNA binding, magnesium ion binding, metal ion binding, nucleotide binding, potassium ion binding, protein binding, protein dimerization activity, protein homodimerization activity, protein tyrosine kinase activity, pyruvate kinase activity, thyroid hormone binding, transcription coactivator activity, transferase activity; CC: cilium, cytoplasm, cytosol, mitochondrion, myelin sheath, nucleus, photoreceptor inner segment, pyruvate kinase complex, rough endoplasmic reticulum
Pathways: Aerobic respiration and respiratory electron transport, Central carbon metabolism in cancer - Mus musculus (mouse), Glucagon signaling pathway - Mus musculus (mouse), Glucose metabolism, Glycolysis, Glycolysis / Gluconeogenesis - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Immune System, Innate Immune System, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Neutrophil degranulation, Purine metabolism - Mus musculus (mouse), Pyruvate metabolism, Pyruvate metabolism - Mus musculus (mouse), Regulation of pyruvate metabolism, Type II diabetes mellitus - Mus musculus (mouse), Viral carcinogenesis - Mus musculus (mouse), glycolysis I, glycolysis III, glycolysis V (Pyrococcus)
UniProt: P52480
Entrez ID: 18746
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Tbcc
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Tbcc in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Tbcc (tubulin-specific chaperone C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: post-chaperonin tubulin folding pathway, protein folding, tubulin complex assembly; MF: GTPase activity, tubulin binding; CC: cytoplasm, cytosol, endoplasmic reticulum, photoreceptor connecting cilium
Pathways:
UniProt: Q8VCN9
Entrez ID: 72726
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Usp8
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Usp8 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Usp8 (ubiquitin specific peptidase 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Ras protein signal transduction, cellular response to dexamethasone stimulus, cellular response to nerve growth factor stimulus, endosome organization, mitotic cytokinesis, negative regulation of lysosomal protein catabolic process, positive regulation of amyloid fibril formation, positive regulation of canonical Wnt signaling pathway, protein K48-linked deubiquitination, protein K63-linked deubiquitination, protein deubiquitination, proteolysis, regulation of protein catabolic process at postsynapse, modulating synaptic transmission, regulation of protein localization, regulation of protein stability; MF: K48-linked deubiquitinase activity, K63-linked deubiquitinase activity, SH3 domain binding, cysteine-type deubiquitinase activity, cysteine-type peptidase activity, hydrolase activity, peptidase activity, protein binding; CC: acrosomal membrane, cytoplasm, cytosol, early endosome, endosome, endosome membrane, glutamatergic synapse, membrane, midbody, nucleus, plasma membrane, postsynaptic density
Pathways: Cushing syndrome - Mus musculus (mouse), Deubiquitination, Downregulation of ERBB2 signaling, Downregulation of ERBB2:ERBB3 signaling, Endocytosis - Mus musculus (mouse), Metabolism of proteins, Mitophagy - animal - Mus musculus (mouse), Negative regulation of MET activity, Post-translational protein modification, Regulation of FZD by ubiquitination, Signal Transduction, Signaling by ERBB2, Signaling by MET, Signaling by Receptor Tyrosine Kinases, Signaling by WNT, TCF dependent signaling in response to WNT, Ub-specific processing proteases
UniProt: Q80U87
Entrez ID: 84092
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Ssbp1
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Ssbp1 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Ssbp1 (single-stranded DNA binding protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA replication, DNA-templated DNA replication, mitochondrion organization, positive regulation of mitochondrial DNA replication, protein homotetramerization; MF: DNA binding, chromatin binding, enzyme activator activity, identical protein binding, protein homodimerization activity, single-stranded DNA binding; CC: mitochondrial nucleoid, mitochondrion
Pathways: DNA Replication, DNA replication - Mus musculus (mouse), Homologous recombination - Mus musculus (mouse), Metabolism of proteins, Mismatch repair - Mus musculus (mouse), Mitochondrial protein degradation, Strand-asynchronous mitochondrial DNA replication
UniProt: Q9CYR0
Entrez ID: 381760
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Chchd3
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Chchd3 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Chchd3 (coiled-coil-helix-coiled-coil-helix domain containing 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cristae formation, inner mitochondrial membrane organization, mitochondrial fusion; MF: molecular adaptor activity, phosphatase binding, protein binding; CC: MICOS complex, cytoplasm, membrane, mitochondrial inner membrane, mitochondrion, nucleus
Pathways:
UniProt: Q9CRB9
Entrez ID: 66075
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Tectb
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Tectb in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Tectb (tectorin beta)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: extracellular matrix structural constituent, protein binding; CC: cell periphery, cell surface, extracellular matrix, extracellular region, extracellular space, membrane, plasma membrane, side of membrane
Pathways: Metabolism of proteins, Post-translational modification: synthesis of GPI-anchored proteins, Post-translational protein modification
UniProt: O08524
Entrez ID: 21684
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Ccl19
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Ccl19 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Ccl19 (C-C motif chemokine ligand 19)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CCL19-activated CCR7 signaling pathway, T cell costimulation, antimicrobial humoral immune response mediated by antimicrobial peptide, cell maturation, cell migration, cellular response to prostaglandin E stimulus, cellular response to virus, chemokine-mediated signaling pathway, chemotaxis, dendritic cell chemotaxis, eosinophil chemotaxis, establishment of T cell polarity, immune response, immunological synapse formation, inflammatory response, killing of cells of another organism, mature conventional dendritic cell differentiation, myeloid dendritic cell chemotaxis, negative regulation of dendritic cell apoptotic process, positive regulation of ERK1 and ERK2 cascade, positive regulation of JNK cascade, positive regulation of Rac protein signal transduction, positive regulation of T cell proliferation, positive regulation of T-helper 1 cell differentiation, positive regulation of canonical NF-kappaB signal transduction, positive regulation of cell migration, positive regulation of cell motility, positive regulation of chemotaxis, positive regulation of dendritic cell antigen processing and presentation, positive regulation of dendritic cell dendrite assembly, positive regulation of endocytosis, positive regulation of glycoprotein biosynthetic process, positive regulation of interleukin-1 beta production, positive regulation of interleukin-12 production, positive regulation of neutrophil chemotaxis, positive regulation of non-canonical NF-kappaB signal transduction, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of phospholipase C/protein kinase C signal transduction, positive regulation of receptor-mediated endocytosis, positive regulation of tumor necrosis factor production, regulation of Cdc42 protein signal transduction, regulation of cell projection assembly, release of sequestered calcium ion into cytosol, response to nitric oxide; MF: CCR chemokine receptor binding, CCR10 chemokine receptor binding, CCR7 chemokine receptor binding, chemokine activity, chemokine receptor binding, cytokine activity; CC: external side of plasma membrane, extracellular region, extracellular space
Pathways: Chemokine receptors bind chemokines, Chemokine signaling pathway - Mus musculus (mouse), Class A/1 (Rhodopsin-like receptors), Cytokine-cytokine receptor interaction - Mus musculus (mouse), G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, NF-kappa B signaling pathway - Mus musculus (mouse), Peptide ligand-binding receptors, Signal Transduction, Signaling by GPCR, Viral protein interaction with cytokine and cytokine receptor - Mus musculus (mouse)
UniProt: O70460
Entrez ID: 24047
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Sp2
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Sp2 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Sp2 (Sp2 transcription factor)
Type: protein-coding
Summary: This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein contains the least conserved DNA-binding domain within the Sp subfamily of proteins, and its DNA sequence specificity differs from the other Sp proteins. The protein can act as a transcriptional activator or repressor, depending on the promoter and cell type. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: circulatory system development, embryonic organ development, fibroblast proliferation, in utero embryonic development, multicellular organism growth, negative regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, histone deacetylase binding, metal ion binding, sequence-specific double-stranded DNA binding, zinc ion binding; CC: nucleoplasm, nucleus
Pathways:
UniProt: Q9D2H6
Entrez ID: 78912
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Dcaf13
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Dcaf13 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Dcaf13 (DDB1 and CUL4 associated factor 13)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: decidualization, epigenetic programming in the zygotic pronuclei, female gamete generation, maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, oocyte growth, proteasome-mediated ubiquitin-dependent protein catabolic process, protein ubiquitination, rRNA processing, ribosome biogenesis, spindle assembly involved in female meiosis; MF: nuclear estrogen receptor binding, protein binding, ubiquitin-like ligase-substrate adaptor activity; CC: Cul4-RING E3 ubiquitin ligase complex, cell junction, centrosome, cytosol, nucleolus, nucleoplasm, nucleus, ribonucleoprotein complex, small-subunit processome
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Neddylation, Post-translational protein modification, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q6PAC3
Entrez ID: 223499
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Gm17019
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Gm17019 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Gm17019 (predicted gene 17019)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: K7N6W5
Entrez ID: 66773
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Serpine1
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Serpine1 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Serpine1 (serine (or cysteine) peptidase inhibitor, clade E, member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to interleukin-1, cellular response to lipopolysaccharide, cellular response to transforming growth factor beta stimulus, cellular response to xenobiotic stimulus, defense response to Gram-negative bacterium, dentinogenesis, female gonad development, negative regulation of blood coagulation, negative regulation of cell adhesion mediated by integrin, negative regulation of cell migration, negative regulation of endothelial cell apoptotic process, negative regulation of extrinsic apoptotic signaling pathway via death domain receptors, negative regulation of fibrinolysis, negative regulation of gene expression, negative regulation of integrin-mediated signaling pathway, negative regulation of plasminogen activation, negative regulation of proteolysis, negative regulation of smooth muscle cell migration, negative regulation of smooth muscle cell-matrix adhesion, negative regulation of thrombin-activated receptor signaling pathway, negative regulation of vascular wound healing, negative regulation of wound healing, placenta development, positive regulation of angiogenesis, positive regulation of blood coagulation, positive regulation of calcium ion import, positive regulation of coagulation, positive regulation of collagen biosynthetic process, positive regulation of epithelium regeneration, positive regulation of fibroblast proliferation, positive regulation of gene expression, positive regulation of inflammatory response, positive regulation of interleukin-8 production, positive regulation of keratinocyte migration, positive regulation of leukotriene production involved in inflammatory response, positive regulation of monocyte chemotaxis, positive regulation of odontoblast differentiation, positive regulation of receptor-mediated endocytosis, regulation of angiogenesis, regulation of cell population proliferation, replicative senescence, response to bacterium; MF: endopeptidase inhibitor activity, peptidase inhibitor activity, protease binding, protein binding, serine-type endopeptidase inhibitor activity, signaling receptor binding; CC: chromaffin granule, extracellular exosome, extracellular matrix, extracellular region, extracellular space, peptidase inhibitor complex, serine protease inhibitor complex
Pathways: AGE-RAGE signaling pathway in diabetic complications - Mus musculus (mouse), Apelin signaling pathway - Mus musculus (mouse), Cellular senescence - Mus musculus (mouse), Chagas disease - Mus musculus (mouse), Complement and coagulation cascades - Mus musculus (mouse), HIF-1 signaling pathway - Mus musculus (mouse), Hippo signaling pathway - Mus musculus (mouse), p53 signaling pathway - Mus musculus (mouse)
UniProt: G5E899
Entrez ID: 18787
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Yae1d1
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Yae1d1 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Yae1d1 (Yae1 domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein maturation; CC: cellular_component, cytoplasm, nucleus
Pathways:
UniProt: A0A1Y7VLX4, Q9DAY6
Entrez ID: 67008
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Paqr5
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Paqr5 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Paqr5 (progestin and adipoQ receptor family member V)
Type: protein-coding
Summary: Predicted to enable signaling receptor activity. Predicted to be involved in oogenesis. Predicted to be located in plasma membrane. Is expressed in bladder; late tubule; urinary system; and urothelium of bladder. Orthologous to human PAQR5 (progestin and adipoQ receptor family member 5). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cell differentiation, oogenesis; MF: lipid binding, signaling receptor activity, steroid binding; CC: membrane, plasma membrane
Pathways: Chemical carcinogenesis - receptor activation - Mus musculus (mouse)
UniProt: Q9DCU0
Entrez ID: 74090
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Tmem186
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Tmem186 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Tmem186 (transmembrane protein 186)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial respiratory chain complex I assembly; CC: membrane, mitochondrial inner membrane, mitochondrion
Pathways: Aerobic respiration and respiratory electron transport, Complex I biogenesis, Metabolism, Respiratory electron transport
UniProt: Q9CR76
Entrez ID: 66690
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Dna2
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Dna2 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Dna2 (DNA replication helicase/nuclease 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA double-strand break processing, DNA repair, DNA replication, DNA replication checkpoint signaling, DNA replication, Okazaki fragment processing, DNA replication, removal of RNA primer, base-excision repair, mitochondrial DNA repair, mitochondrial DNA replication, mitotic telomere maintenance via semi-conservative replication, positive regulation of DNA replication, replication fork reversal, telomere maintenance, telomere maintenance via semi-conservative replication; MF: 4 iron, 4 sulfur cluster binding, 5'-3' DNA helicase activity, 5'-flap endonuclease activity, ATP binding, ATP hydrolysis activity, DNA binding, DNA helicase activity, RNA binding, catalytic activity, deoxyribonuclease (pyrimidine dimer) activity, endonuclease activity, helicase activity, hydrolase activity, iron-sulfur cluster binding, metal ion binding, nuclease activity, nucleotide binding, protein binding, single-stranded DNA helicase activity; CC: chromosome, telomeric region, cytoplasm, gamma DNA polymerase complex, mitochondrial nucleoid, mitochondrion, nucleoplasm, nucleus
Pathways: Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Chromosome Maintenance, DNA Double-Strand Break Repair, DNA Repair, DNA Replication, DNA replication - Mus musculus (mouse), DNA strand elongation, Extension of Telomeres, G2/M Checkpoints, G2/M DNA damage checkpoint, Gene expression (Transcription), Generic Transcription Pathway, HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), HDR through Single Strand Annealing (SSA), Homologous DNA Pairing and Strand Exchange, Homology Directed Repair, Lagging Strand Synthesis, Presynaptic phase of homologous DNA pairing and strand exchange, Processing of DNA double-strand break ends, Processive synthesis on the C-strand of the telomere, Processive synthesis on the lagging strand, RNA Polymerase II Transcription, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Removal of the Flap Intermediate, Removal of the Flap Intermediate from the C-strand, Resolution of D-Loop Structures, Resolution of D-loop Structures through Holliday Junction Intermediates, S Phase, Synthesis of DNA, Telomere C-strand (Lagging Strand) Synthesis, Telomere Maintenance, Transcriptional Regulation by TP53
UniProt: Q6ZQJ5
Entrez ID: 327762
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Jun
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Jun in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Jun (jun proto-oncogene)
Type: protein-coding
Summary: Enables chromatin binding activity and transcription cis-regulatory region binding activity. Involved in cellular response to anisomycin and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including circulatory system development; eyelid development in camera-type eye; and positive regulation of cell population proliferation. Located in nucleus. Part of transcription factor AP-1 complex and transcription repressor complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; long bone; and sensory organ. Used to study psoriasis and pulmonary emphysema. Human ortholog(s) of this gene implicated in pulmonary tuberculosis. Orthologous to human JUN (Jun proto-oncogene, AP-1 transcription factor subunit). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: DNA-templated transcription, JNK cascade, SMAD protein signal transduction, angiogenesis, axon regeneration, cellular response to anisomycin, cellular response to calcium ion, cellular response to hypoxia, cellular response to potassium ion starvation, cellular response to prolactin, cellular response to zinc ion starvation, circadian rhythm, eyelid development in camera-type eye, host-mediated activation of viral transcription, host-mediated suppression of viral transcription, leading edge cell differentiation, learning, liver development, membrane depolarization, microglial cell activation, monocyte differentiation, negative regulation of DNA-templated transcription, negative regulation of apoptotic process, negative regulation of cell population proliferation, negative regulation of neuron apoptotic process, negative regulation of transcription by RNA polymerase II, outflow tract morphogenesis, positive regulation of DNA replication, positive regulation of DNA-templated transcription, positive regulation of DNA-templated transcription initiation, positive regulation of ERK1 and ERK2 cascade, positive regulation of apoptotic process, positive regulation of apoptotic signaling pathway, positive regulation of cell population proliferation, positive regulation of endothelial cell proliferation, positive regulation of epithelial cell migration, positive regulation of fibroblast proliferation, positive regulation of miRNA transcription, positive regulation of monocyte differentiation, positive regulation of neuron apoptotic process, positive regulation of smooth muscle cell proliferation, positive regulation of transcription by RNA polymerase II, positive regulation of vascular associated smooth muscle cell proliferation, regulation of DNA-templated transcription, regulation of cell cycle, regulation of cell population proliferation, regulation of transcription by RNA polymerase II, release from viral latency, release of cytochrome c from mitochondria, response to cAMP, response to cytokine, response to endoplasmic reticulum stress, response to ethanol, response to forskolin, response to hydrogen peroxide, response to insulin, response to lipopolysaccharide, response to mechanical stimulus, response to muscle stretch, response to steroid hormone, response to xenobiotic stimulus, transcription by RNA polymerase II, transforming growth factor beta receptor signaling pathway; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, GTPase activator activity, HMG box domain binding, R-SMAD binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, cAMP response element binding, chromatin binding, double-stranded DNA binding, enzyme binding, general transcription initiation factor binding, identical protein binding, protein binding, protein-containing complex binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding, ubiquitin protein ligase binding, ubiquitin-like protein ligase binding; CC: RNA polymerase II transcription regulator complex, chromatin, cytosol, euchromatin, nucleoplasm, nucleus, protein-containing complex, transcription factor AP-1 complex, transcription regulator complex, transcription repressor complex
Pathways: AGE-RAGE signaling pathway in diabetic complications - Mus musculus (mouse), Activation of the AP-1 family of transcription factors, Amphetamine addiction - Mus musculus (mouse), Apoptosis - Mus musculus (mouse), B cell receptor signaling pathway - Mus musculus (mouse), Breast cancer - Mus musculus (mouse), C-type lectin receptor signaling pathway - Mus musculus (mouse), Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, Chagas disease - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Choline metabolism in cancer - Mus musculus (mouse), Cocaine addiction - Mus musculus (mouse), Colorectal cancer - Mus musculus (mouse), Coronavirus disease - COVID-19 - Mus musculus (mouse), Cytokine Signaling in Immune system, Epstein-Barr virus infection - Mus musculus (mouse), ErbB signaling pathway - Mus musculus (mouse), Estrogen signaling pathway - Mus musculus (mouse), FCERI mediated MAPK activation, Fc epsilon receptor (FCERI) signaling, Fluid shear stress and atherosclerosis - Mus musculus (mouse), Focal adhesion - Mus musculus (mouse), GnRH signaling pathway - Mus musculus (mouse), Hepatitis B - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), IL-17 signaling pathway - Mus musculus (mouse), Immune System, Inflammatory bowel disease - Mus musculus (mouse), Innate Immune System, Interleukin-17 signaling, Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Leishmaniasis - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), MAP kinase activation, MAPK signaling pathway - Mus musculus (mouse), MAPK targets/ Nuclear events mediated by MAP kinases, Measles - Mus musculus (mouse), Mitophagy - animal - Mus musculus (mouse), MyD88 cascade initiated on plasma membrane, MyD88 dependent cascade initiated on endosome, MyD88-independent TLR4 cascade , MyD88:MAL(TIRAP) cascade initiated on plasma membrane, NOD-like receptor signaling pathway - Mus musculus (mouse), Neurotrophin signaling pathway - Mus musculus (mouse), Non-alcoholic fatty liver disease - Mus musculus (mouse), Osteoclast differentiation - Mus musculus (mouse), Oxidative Stress Induced Senescence, Oxytocin signaling pathway - Mus musculus (mouse), PD-L1 expression and PD-1 checkpoint pathway in cancer - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Pertussis - Mus musculus (mouse), Relaxin signaling pathway - Mus musculus (mouse), Renal cell carcinoma - Mus musculus (mouse), Rheumatoid arthritis - Mus musculus (mouse), Salmonella infection - Mus musculus (mouse), Signaling by Interleukins, T cell receptor signaling pathway - Mus musculus (mouse), TNF signaling pathway - Mus musculus (mouse), TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, TRIF (TICAM1)-mediated TLR4 signaling , Th1 and Th2 cell differentiation - Mus musculus (mouse), Th17 cell differentiation - Mus musculus (mouse), Tight junction - Mus musculus (mouse), Toll Like Receptor 10 (TLR10) Cascade, Toll Like Receptor 2 (TLR2) Cascade, Toll Like Receptor 3 (TLR3) Cascade, Toll Like Receptor 4 (TLR4) Cascade, Toll Like Receptor 5 (TLR5) Cascade, Toll Like Receptor 7/8 (TLR7/8) Cascade, Toll Like Receptor 9 (TLR9) Cascade, Toll Like Receptor TLR1:TLR2 Cascade, Toll Like Receptor TLR6:TLR2 Cascade, Toll-like Receptor Cascades, Toll-like receptor signaling pathway - Mus musculus (mouse), Viral carcinogenesis - Mus musculus (mouse), Wnt signaling pathway - Mus musculus (mouse), Yersinia infection - Mus musculus (mouse), cAMP signaling pathway - Mus musculus (mouse)
UniProt: P05627
Entrez ID: 16476
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Smu1
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Smu1 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Smu1 (smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, mRNA processing, mRNA splicing, via spliceosome, regulation of alternative mRNA splicing, via spliceosome; CC: U2-type precatalytic spliceosome, cytoplasm, nuclear speck, nucleoplasm, nucleus, precatalytic spliceosome, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q3UKJ7
Entrez ID: 74255
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Cherp
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Cherp in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Cherp (calcium homeostasis endoplasmic reticulum protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA processing, intracellular calcium ion homeostasis, negative regulation of cell population proliferation, positive regulation of calcineurin-NFAT signaling cascade, release of sequestered calcium ion into cytosol; MF: RNA binding, nucleic acid binding, protein binding, transmembrane transporter binding; CC: cytoplasm, endoplasmic reticulum, perinuclear region of cytoplasm, sarcoplasmic reticulum membrane
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q8CGZ0
Entrez ID: 27967
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Gtpbp4
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Gtpbp4 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Gtpbp4 (GTP binding protein 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), negative regulation of DNA replication, negative regulation of G2/M transition of mitotic cell cycle, negative regulation of cell migration, negative regulation of cell population proliferation, negative regulation of cell-cell adhesion, negative regulation of protein ubiquitination, protein stabilization, ribosomal large subunit biogenesis, ribosome biogenesis; MF: GTP binding, GTPase activity, RNA binding, nucleotide binding, preribosome binding; CC: cytoplasm, cytosol, nuclear membrane, nucleolus, nucleoplasm, nucleus, perinuclear region of cytoplasm
Pathways: Ribosome biogenesis in eukaryotes - Mus musculus (mouse)
UniProt: Q99ME9
Entrez ID: 69237
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Abcf2
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Abcf2 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Abcf2 (ATP-binding cassette, sub-family F member 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: ATP binding, ATP hydrolysis activity, nucleotide binding, protein binding
Pathways:
UniProt: Q99LE6
Entrez ID: 27407
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Sptlc2
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Sptlc2 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Sptlc2 (serine palmitoyltransferase, long chain base subunit 2)
Type: protein-coding
Summary: This gene encodes a long chain base subunit of serine palmitoyltransferase. The enzyme, serine palmitoyltransferase, consists of two different subunits, and is the key enzyme in sphingolipid biosynthesis. It catalyzes the pyridoxal-5-prime-phosphate-dependent condensation of L-serine and palmitoyl-CoA to 3-oxosphinganine. A mutant allele of this gene in mice is used as a model for the human disease 'Susceptibilty to Psoriasis 1'. Mutations in the human gene are associated with hereditary sensory neuropathy type I. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: adipose tissue development, ceramide biosynthetic process, lipid metabolic process, positive regulation of lipophagy, sphinganine biosynthetic process, sphingolipid biosynthetic process, sphingolipid metabolic process, sphingomyelin biosynthetic process, sphingosine biosynthetic process; MF: acyltransferase activity, pyridoxal phosphate binding, serine C-palmitoyltransferase activity, transferase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, mitochondrion, serine palmitoyltransferase complex
Pathways: Metabolism, Metabolism of lipids, Sphingolipid de novo biosynthesis, Sphingolipid metabolism, Sphingolipid metabolism - Mus musculus (mouse), Sphingolipid signaling pathway - Mus musculus (mouse), ceramide biosynthesis
UniProt: P97363
Entrez ID: 20773
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Irf9
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Irf9 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Irf9 (interferon regulatory factor 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: defense response to protozoan, dendritic cell differentiation, immune system process, lymphocyte activation involved in immune response, lymphocyte differentiation, myeloid cell differentiation, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, protein binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding; CC: ISGF3 complex, cytosol, nucleus
Pathways: C-type lectin receptor signaling pathway - Mus musculus (mouse), Coronavirus disease - COVID-19 - Mus musculus (mouse), Cytokine Signaling in Immune system, Epstein-Barr virus infection - Mus musculus (mouse), Hepatitis C - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Immune System, Influenza A - Mus musculus (mouse), Interferon Signaling, Interferon alpha/beta signaling, JAK-STAT signaling pathway - Mus musculus (mouse), Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Measles - Mus musculus (mouse), NOD-like receptor signaling pathway - Mus musculus (mouse), Necroptosis - Mus musculus (mouse), Osteoclast differentiation - Mus musculus (mouse), Viral carcinogenesis - Mus musculus (mouse)
UniProt: Q61179
Entrez ID: 16391
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Sdhd
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Sdhd in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Sdhd (succinate dehydrogenase complex, subunit D, integral membrane protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to hypoxia, mitochondrial electron transport, succinate to ubiquinone, proton motive force-driven mitochondrial ATP synthesis, regulation of catecholamine secretion, tricarboxylic acid cycle; MF: heme binding, metal ion binding, succinate dehydrogenase (quinone) activity, ubiquinone binding; CC: membrane, mitochondrial envelope, mitochondrial inner membrane, mitochondrion, respiratory chain complex II (succinate dehydrogenase)
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Citrate cycle (TCA cycle) - Mus musculus (mouse), Citric acid cycle (TCA cycle), Diabetic cardiomyopathy - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Maturation of TCA enzymes and regulation of TCA cycle, Metabolism, Non-alcoholic fatty liver disease - Mus musculus (mouse), Oxidative phosphorylation - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), TCA cycle, TCA cycle variation III (eukaryotic), Thermogenesis - Mus musculus (mouse), aerobic respiration -- electron donor II, aerobic respiration -- electron donors reaction list
UniProt: Q9CXV1
Entrez ID: 66925
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Ten1
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Ten1 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Ten1 (TEN1 telomerase capping complex subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of telomere maintenance via telomerase; MF: DNA binding, single-stranded DNA binding, telomerase inhibitor activity, telomeric DNA binding; CC: CST complex, chromosome, chromosome, telomeric region, nucleoplasm, nucleus
Pathways: Cell Cycle, Chromosome Maintenance, Extension of Telomeres, Polymerase switching on the C-strand of the telomere, Telomere C-strand (Lagging Strand) Synthesis, Telomere C-strand synthesis initiation, Telomere Maintenance
UniProt: Q9D7K2
Entrez ID: 69535
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Tprkb
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Tprkb in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Tprkb (Tp53rk binding protein)
Type: protein-coding
Summary: Predicted to enable protein kinase binding activity. Predicted to be involved in tRNA threonylcarbamoyladenosine modification. Predicted to be located in cytoplasm. Predicted to be part of EKC/KEOPS complex. Predicted to be active in cytosol and nucleus. Human ortholog(s) of this gene implicated in Galloway-Mowat syndrome 5. Orthologous to human TPRKB (TP53RK binding protein). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: tRNA processing, tRNA threonylcarbamoyladenosine modification; MF: protein kinase binding; CC: EKC/KEOPS complex, cytoplasm, cytosol, nucleus
Pathways:
UniProt: Q8QZZ7
Entrez ID: 69786
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Sirt6
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Sirt6 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Sirt6 (sirtuin 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, DNA repair-dependent chromatin remodeling, Ras protein signal transduction, base-excision repair, cardiac muscle cell differentiation, cellular response to angiotensin, cellular response to endothelin, cellular response to hydrogen peroxide, chromatin organization, chromatin remodeling, circadian regulation of gene expression, determination of adult lifespan, double-strand break repair, gluconeogenesis, glucose homeostasis, glycolytic process, inflammatory response, ketone biosynthetic process, negative regulation of D-glucose import, negative regulation of DNA-templated transcription, negative regulation of cell population proliferation, negative regulation of cellular senescence, negative regulation of gene expression, epigenetic, negative regulation of gluconeogenesis, negative regulation of glycolytic process, negative regulation of protein import into nucleus, negative regulation of protein localization to chromatin, negative regulation of transcription by RNA polymerase II, negative regulation of transcription elongation by RNA polymerase II, pericentric heterochromatin formation, positive regulation of blood vessel branching, positive regulation of cellular senescence, positive regulation of chondrocyte proliferation, positive regulation of cold-induced thermogenesis, positive regulation of double-strand break repair, positive regulation of fat cell differentiation, positive regulation of fibroblast proliferation, positive regulation of gluconeogenesis, positive regulation of insulin secretion, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of protein export from nucleus, positive regulation of protein localization to chromatin, positive regulation of stem cell differentiation, positive regulation of stem cell population maintenance, positive regulation of stem cell proliferation, positive regulation of telomere maintenance, positive regulation of transcription by RNA polymerase II, positive regulation of vascular endothelial cell proliferation, post-embryonic cardiac muscle cell growth involved in heart morphogenesis, protein deacetylation, protein delipidation, protein destabilization, protein import into nucleus, protein localization to site of double-strand break, protein poly-ADP-ribosylation, regulation of circadian rhythm, regulation of double-strand break repair via homologous recombination, regulation of lipid catabolic process, regulation of lipid metabolic process, regulation of protein export from nucleus, regulation of protein localization to plasma membrane, regulation of protein secretion, response to UV, response to nutrient levels, subtelomeric heterochromatin formation, transcription pausing by RNA polymerase II, transposable element silencing; MF: DNA binding, DNA damage sensor activity, NAD+ binding, NAD+-protein mono-ADP-ribosyltransferase activity, NAD+-protein-arginine ADP-ribosyltransferase activity, NAD+-protein-lysine ADP-ribosyltransferase activity, NAD-dependent protein demyristoylase activity, NAD-dependent protein depalmitoylase activity, NAD-dependent protein lysine deacetylase activity, RNA binding, TORC2 complex binding, acyltransferase activity, chromatin DNA binding, chromatin binding, damaged DNA binding, enzyme regulator activity, glycosyltransferase activity, histone H3K18 deacetylase activity, NAD-dependent, histone H3K56 deacetylase activity, NAD-dependent, histone H3K9 deacetylase activity, NAD-dependent, histone H3K9 deacetylase activity, hydrolytic mechanism, histone deacetylase activity, NAD-dependent, histone deacetylase regulator activity, lncRNA binding, metal ion binding, nucleosome binding, nucleotidyltransferase activity, protein homodimerization activity, protein lysine deacetylase activity, transcription corepressor activity, transferase activity, zinc ion binding; CC: chromatin, chromosome, chromosome, subtelomeric region, chromosome, telomeric region, endoplasmic reticulum, nucleolus, nucleoplasm, nucleus, pericentric heterochromatin, site of DNA damage, site of double-strand break
Pathways: Central carbon metabolism in cancer - Mus musculus (mouse), DNA Double-Strand Break Repair, DNA Repair, HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homology Directed Repair, Nicotinate and nicotinamide metabolism - Mus musculus (mouse), Processing of DNA double-strand break ends, Thermogenesis - Mus musculus (mouse)
UniProt: P59941
Entrez ID: 50721
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Med4
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Med4 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Med4 (mediator complex subunit 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA polymerase II preinitiation complex assembly, positive regulation of DNA-templated transcription, positive regulation of transcription elongation by RNA polymerase II, positive regulation of transcription initiation by RNA polymerase II, regulation of transcription by RNA polymerase II, transcription by RNA polymerase II; MF: nuclear thyroid hormone receptor binding, protein binding, transcription coactivator activity, transcription coregulator activity; CC: core mediator complex, mediator complex, nucleoplasm, nucleus
Pathways: Thyroid hormone signaling pathway - Mus musculus (mouse)
UniProt: Q9CQA5
Entrez ID: 67381
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Ipo11
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Ipo11 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Ipo11 (importin 11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intracellular protein transport, nucleocytoplasmic transport, protein import into nucleus, protein transport, ribosomal protein import into nucleus; MF: nuclear import signal receptor activity, protein binding, small GTPase binding; CC: cytoplasm, cytosol, nuclear envelope, nucleoplasm, nucleus
Pathways: Nucleocytoplasmic transport - Mus musculus (mouse)
UniProt: Q8K2V6
Entrez ID: 76582
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Mrpl19
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Mrpl19 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Mrpl19 (mitochondrial ribosomal protein L19)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial translation, translation; MF: structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrial ribosome, mitochondrion, nucleus, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Ribosome - Mus musculus (mouse), Translation
UniProt: Q9D338
Entrez ID: 56284
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Rabggta
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Rabggta in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Rabggta (Rab geranylgeranyl transferase, a subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: Rab geranylgeranyltransferase activity, prenyltransferase activity, protein geranylgeranyltransferase activity, protein prenyltransferase activity, small GTPase binding, transferase activity, zinc ion binding; CC: Rab-protein geranylgeranyltransferase complex, cytoplasm
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Metabolism of proteins, Post-translational protein modification, RAB geranylgeranylation, RNA Polymerase II Transcription, TP53 Regulates Transcription of Cell Death Genes, TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain, Transcriptional Regulation by TP53
UniProt: Q9JHK4
Entrez ID: 56187
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Rpl7l1
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Rpl7l1 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Rpl7l1 (ribosomal protein L7-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: blastocyst formation, maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); MF: RNA binding, structural constituent of ribosome; CC: cytosol, cytosolic large ribosomal subunit, nucleolus, ribonucleoprotein complex, ribosome
Pathways:
UniProt: Q9D8M4
Entrez ID: 66229
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Coq4
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Coq4 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Coq4 (coenzyme Q4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ubiquinone biosynthetic process; MF: 4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase activity, carboxy-lyase activity, lyase activity, metal ion binding, molecular_function; CC: extrinsic component of mitochondrial inner membrane, membrane, mitochondrial inner membrane, mitochondrial matrix, mitochondrion, protein-containing complex, ubiquinone biosynthesis complex
Pathways: Metabolism, Metabolism of cofactors, Metabolism of vitamins and cofactors, Ubiquinol biosynthesis
UniProt: Q8BGB8
Entrez ID: 227683
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Camk1d
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Camk1d in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Camk1d (calcium/calmodulin-dependent protein kinase ID)
Type: protein-coding
Summary: Predicted to enable calcium/calmodulin-dependent protein kinase activity and calmodulin binding activity. Involved in positive regulation of neuron projection development and positive regulation of neutrophil chemotaxis. Acts upstream of or within negative regulation of apoptotic process and positive regulation of apoptotic process. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Is expressed in central nervous system; liver; and retina. Orthologous to human CAMK1D (calcium/calmodulin dependent protein kinase ID). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: inflammatory response, negative regulation of apoptotic process, nervous system development, positive regulation of CREB transcription factor activity, positive regulation of apoptotic process, positive regulation of neuron projection development, positive regulation of neutrophil chemotaxis, positive regulation of phagocytosis, positive regulation of respiratory burst, regulation of dendrite development, regulation of granulocyte chemotaxis, regulation of neuron projection development, signal transduction; MF: ATP binding, calcium/calmodulin-dependent protein kinase activity, calmodulin binding, catalytic activity, kinase activity, nucleotide binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cytoplasm, nucleus
Pathways:
UniProt: Q8BW96
Entrez ID: 227541
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Ints5
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Ints5 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Ints5 (integrator complex subunit 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA polymerase II transcription initiation surveillance, snRNA 3'-end processing, snRNA processing; CC: INTAC complex, cytoplasm, cytosol, integrator complex, membrane, nuclear membrane, nucleoplasm, nucleus
Pathways: Gene expression (Transcription), RNA Polymerase II Transcription, RNA polymerase II transcribes snRNA genes
UniProt: Q8CHT3
Entrez ID: 109077
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Lsm12
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Lsm12 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Lsm12 (LSM12 homolog)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: RNA binding, molecular_function; CC: cellular_component, cytoplasm
Pathways:
UniProt: Q9D0R8
Entrez ID: 268490
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Dctn5
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Dctn5 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Dctn5 (dynactin 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: aorta development, coronary vasculature development, ventricular septum development; CC: centrosome, chromosome, chromosome, centromeric region, cytoplasm, cytoskeleton, dynactin complex, kinetochore, nuclear membrane, nucleoplasm
Pathways: Adaptive Immune System, Amyotrophic lateral sclerosis - Mus musculus (mouse), Asparagine N-linked glycosylation, COPI-independent Golgi-to-ER retrograde traffic, COPI-mediated anterograde transport, Cellular responses to stimuli, Cellular responses to stress, ER to Golgi Anterograde Transport, Golgi-to-ER retrograde transport, HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand, Huntington disease - Mus musculus (mouse), Immune System, Intra-Golgi and retrograde Golgi-to-ER traffic, MHC class II antigen presentation, Membrane Trafficking, Metabolism of proteins, Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Post-translational protein modification, Salmonella infection - Mus musculus (mouse), Transport to the Golgi and subsequent modification, Vasopressin-regulated water reabsorption - Mus musculus (mouse), Vesicle-mediated transport
UniProt: Q9QZB9
Entrez ID: 59288
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Rpa2
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Rpa2 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Rpa2 (replication protein A2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, DNA replication, base-excision repair, double-strand break repair via homologous recombination, mismatch repair, mitotic G1 DNA damage checkpoint signaling, nucleotide-excision repair, protein localization to chromosome, regulation of DNA damage checkpoint, regulation of double-strand break repair via homologous recombination, telomere maintenance; MF: DNA binding, G-rich strand telomeric DNA binding, damaged DNA binding, enzyme binding, protein binding, protein phosphatase binding, single-stranded DNA binding, telomeric DNA binding, ubiquitin protein ligase binding; CC: DNA replication factor A complex, PML body, chromatin, chromosome, telomeric region, nuclear body, nucleoplasm, nucleus, site of double-strand break
Pathways: Activation of ATR in response to replication stress, Activation of the pre-replicative complex, Base Excision Repair, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Chromosome Maintenance, DNA Damage Bypass, DNA Double-Strand Break Repair, DNA Repair, DNA Replication, DNA Replication Pre-Initiation, DNA replication - Mus musculus (mouse), DNA strand elongation, Dual Incision in GG-NER, Dual incision in TC-NER, Extension of Telomeres, Fanconi Anemia Pathway, Fanconi anemia pathway - Mus musculus (mouse), Formation of Incision Complex in GG-NER, G1/S Transition, G2/M Checkpoints, G2/M DNA damage checkpoint, Gap-filling DNA repair synthesis and ligation in GG-NER, Gap-filling DNA repair synthesis and ligation in TC-NER, Gene expression (Transcription), Generic Transcription Pathway, Global Genome Nucleotide Excision Repair (GG-NER), HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), HDR through Single Strand Annealing (SSA), Homologous recombination - Mus musculus (mouse), Homology Directed Repair, Lagging Strand Synthesis, Mismatch Repair, Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta), Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha), Mismatch repair - Mus musculus (mouse), Mitotic G1 phase and G1/S transition, Nucleotide Excision Repair, Nucleotide excision repair - Mus musculus (mouse), PCNA-Dependent Long Patch Base Excision Repair, Processing of DNA double-strand break ends, Processive synthesis on the C-strand of the telomere, Processive synthesis on the lagging strand, RNA Polymerase II Transcription, Recognition of DNA damage by PCNA-containing replication complex, Regulation of HSF1-mediated heat shock response, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Removal of the Flap Intermediate, Removal of the Flap Intermediate from the C-strand, Resolution of AP sites via the multiple-nucleotide patch replacement pathway, Resolution of Abasic Sites (AP sites), S Phase, Synthesis of DNA, Telomere C-strand (Lagging Strand) Synthesis, Telomere Maintenance, Termination of translesion DNA synthesis, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Transcriptional Regulation by TP53, Translesion Synthesis by POLH, Translesion synthesis by POLI, Translesion synthesis by POLK, Translesion synthesis by REV1, Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
UniProt: Q62193
Entrez ID: 19891
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Pbrm1
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Pbrm1 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Pbrm1 (polybromo 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: blastocyst formation, blood vessel remodeling, cardiac vascular smooth muscle cell development, chromatin organization, chromatin remodeling, epicardium-derived cardiac endothelial cell differentiation, heart development, heart morphogenesis, negative regulation of cell population proliferation, placenta development, positive regulation of DNA-templated transcription, positive regulation of T cell differentiation, positive regulation of cell differentiation, positive regulation of dendritic spine development, positive regulation of double-strand break repair, positive regulation of myoblast differentiation, regulation of G0 to G1 transition, regulation of G1/S transition of mitotic cell cycle, regulation of mitotic metaphase/anaphase transition, regulation of nucleotide-excision repair, regulation of transcription by RNA polymerase II, transcription elongation by RNA polymerase II, vasculogenesis involved in coronary vascular morphogenesis; MF: DNA binding, chromatin binding, protein binding; CC: RSC-type complex, SWI/SNF complex, chromatin, chromosome, kinetochore, nuclear matrix, nucleoplasm, nucleus
Pathways: Hepatocellular carcinoma - Mus musculus (mouse)
UniProt: Q8BSQ9
Entrez ID: 66923
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Dhx38
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Dhx38 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Dhx38 (DEAH-box helicase 38)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, mRNA processing, mRNA splicing, via spliceosome; MF: 3'-5' RNA helicase activity, ATP binding, ATP-dependent activity, acting on RNA, RNA binding, RNA helicase activity, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding; CC: catalytic step 2 spliceosome, nucleus, spliceosomal complex
Pathways: Gene expression (Transcription), Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, Spliceosome - Mus musculus (mouse), Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA derived from an Intron-Containing Transcript, mRNA 3'-end processing, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q80X98
Entrez ID: 64340
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Riok1
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Riok1 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Riok1 (RIO kinase 1)
Type: protein-coding
Summary: This gene encodes a member of the RIO family of atypical serine protein kinases. A similar protein in humans is a component of the protein arginine methyltransferase 5 complex that specifically recruits the RNA-binding protein nucleolin as a methylation substrate. [provided by RefSeq, Feb 2011].
Gene Ontology: BP: maturation of SSU-rRNA, positive regulation of rRNA processing, ribosomal small subunit biogenesis, ribosome biogenesis; MF: ATP binding, ATP hydrolysis activity, catalytic activity, hydrolase activity, kinase activity, metal ion binding, nucleotide binding, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cytoplasm, cytosol, methyltransferase complex, preribosome, small subunit precursor
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Ribosome biogenesis in eukaryotes - Mus musculus (mouse), rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q922Q2
Entrez ID: 71340
|
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