screen_file
string | organism
string | perturbation
string | gene
string | cell
string | phenotype
string | hit
int64 | benchmark_type
string | prompt
string | gene_context
string |
|---|---|---|---|---|---|---|---|---|---|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Rprd1b
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Rprd1b in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Rprd1b (regulation of nuclear pre-mRNA domain containing 1B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA polymerase II promoter clearance, mRNA 3'-end processing, positive regulation of cell population proliferation, positive regulation of transcription by RNA polymerase II, regulation of cell cycle process; MF: RNA polymerase II C-terminal domain binding, RNA polymerase II complex binding, identical protein binding; CC: nucleoplasm, nucleus, transcription preinitiation complex
Pathways: Gene expression (Transcription), RNA Polymerase II Transcription, RNA polymerase II transcribes snRNA genes
UniProt: Q9CSU0
Entrez ID: 70470
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Cdk4
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Cdk4 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Cdk4 (cyclin dependent kinase 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G1/S transition of mitotic cell cycle, cell division, cellular response to interleukin-4, cellular response to ionomycin, cellular response to lipopolysaccharide, cellular response to phorbol 13-acetate 12-myristate, positive regulation of G2/M transition of mitotic cell cycle, positive regulation of apoptotic process, positive regulation of cell population proliferation, positive regulation of cell size, positive regulation of epithelial cell proliferation, positive regulation of fibroblast proliferation, positive regulation of translation, regulation of G2/M transition of mitotic cell cycle, regulation of cell cycle, regulation of gene expression, regulation of type B pancreatic cell proliferation, response to testosterone, response to xenobiotic stimulus, signal transduction; MF: ATP binding, cyclin binding, cyclin-dependent protein serine/threonine kinase activity, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, protein-containing complex binding, transferase activity; CC: bicellular tight junction, chromatin, cyclin D1-CDK4 complex, cyclin D2-CDK4 complex, cyclin D3-CDK4 complex, cyclin-dependent protein kinase holoenzyme complex, cytoplasm, cytosol, membrane, nuclear membrane, nucleolus, nucleoplasm, nucleus, perinuclear region of cytoplasm, transcription regulator complex
Pathways: AGE-RAGE signaling pathway in diabetic complications - Mus musculus (mouse), Adaptive Immune System, Bladder cancer - Mus musculus (mouse), Breast cancer - Mus musculus (mouse), Cell Cycle, Cell Cycle, Mitotic, Cell cycle - Mus musculus (mouse), Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, Cellular senescence - Mus musculus (mouse), Chromatin modifying enzymes, Chromatin organization, Chronic myeloid leukemia - Mus musculus (mouse), Co-inhibition by PD-1, Cushing syndrome - Mus musculus (mouse), Cyclin A:Cdk2-associated events at S phase entry, Cyclin D associated events in G1, Cyclin E associated events during G1/S transition , Developmental Biology, Drug-mediated inhibition of CDK4/CDK6 activity, Epstein-Barr virus infection - Mus musculus (mouse), G1 Phase, G1/S Transition, Gene expression (Transcription), Generic Transcription Pathway, Glioma - Mus musculus (mouse), Hepatitis C - Mus musculus (mouse), Hepatocellular carcinoma - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Immune System, Influenza A - Mus musculus (mouse), Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Measles - Mus musculus (mouse), Melanoma - Mus musculus (mouse), Mitotic G1 phase and G1/S transition, Non-small cell lung cancer - Mus musculus (mouse), Oncogene Induced Senescence, Oxidative Stress Induced Senescence, PI3K-Akt signaling pathway - Mus musculus (mouse), PTK6 Regulates Cell Cycle, Pancreatic cancer - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), RMTs methylate histone arginines, RNA Polymerase II Transcription, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of T cell activation by CD28 family, S Phase, SCF(Skp2)-mediated degradation of p27/p21, SPOP-mediated proteasomal degradation of PD-L1(CD274), Senescence-Associated Secretory Phenotype (SASP), Signal Transduction, Signaling by Non-Receptor Tyrosine Kinases, Signaling by PTK6, Small cell lung cancer - Mus musculus (mouse), T cell receptor signaling pathway - Mus musculus (mouse), Tight junction - Mus musculus (mouse), Transcriptional regulation by RUNX2, Transcriptional regulation of granulopoiesis, Ubiquitin-dependent degradation of Cyclin D, Viral carcinogenesis - Mus musculus (mouse), p53 signaling pathway - Mus musculus (mouse)
UniProt: P30285
Entrez ID: 12567
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Vmn2r42
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Vmn2r42 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Vmn2r42 (vomeronasal 2, receptor 42)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, signal transduction; MF: G protein-coupled receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: D3YZ97, O35192, D3Z1K8, A0A3B2W896
Entrez ID: 22310
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Kdm2a
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Kdm2a in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Kdm2a (lysine (K)-specific demethylase 2A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, chromatin remodeling, circadian regulation of gene expression, double-strand break repair via nonhomologous end joining, embryonic organ morphogenesis, heart looping, in utero embryonic development, multicellular organism growth, negative regulation of apoptotic process, negative regulation of gene expression, negative regulation of transcription by competitive promoter binding, neural tube closure, neuroepithelial cell differentiation, neuron differentiation, positive regulation of gene expression, regulation of circadian rhythm, regulation of transcription by RNA polymerase II, rhythmic process, transcription initiation-coupled chromatin remodeling; MF: DNA binding, catalytic activity, dioxygenase activity, histone H3K36 demethylase activity, histone H3K36me/H3K36me2 demethylase activity, histone demethylase activity, metal ion binding, oxidoreductase activity, transcription coregulator activity, unmethylated CpG binding, zinc ion binding; CC: chromatin, chromosome, nucleoplasm, nucleus
Pathways: Chromatin modifying enzymes, Chromatin organization, HDMs demethylate histones
UniProt: P59997
Entrez ID: 225876
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Krtap5-4
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Krtap5-4 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Krtap5-4 (keratin associated protein 5-4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, cytosol, intermediate filament, keratin filament
Pathways: Developmental Biology, Keratinization
UniProt: Q62220
Entrez ID: 50775
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Mybl2
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Mybl2 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Mybl2 (myeloblastosis oncogene-like 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to leukemia inhibitory factor, mitotic cell cycle, mitotic spindle assembly, positive regulation of neuron apoptotic process, positive regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: Myb complex, cytosol, nucleoplasm, nucleus
Pathways: Cellular senescence - Mus musculus (mouse)
UniProt: P48972
Entrez ID: 17865
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Lonp1
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Lonp1 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Lonp1 (lon peptidase 1, mitochondrial)
Type: protein-coding
Summary: Enables several functions, including ATP hydrolysis activity; ATP-dependent peptidase activity; and DNA binding activity. Acts upstream of or within negative regulation of insulin receptor signaling pathway; proteolysis; and regulation of peptidyl-tyrosine phosphorylation. Located in mitochondrion. Is expressed in several structures, including adrenal medulla; genitourinary system; gut; lung; and submandibular gland primordium. Human ortholog(s) of this gene implicated in CODAS syndrome. Orthologous to human LONP1 (lon peptidase 1, mitochondrial). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cellular response to oxidative stress, chaperone-mediated protein complex assembly, mitochondrial protein catabolic process, mitochondrion organization, negative regulation of insulin receptor signaling pathway, oxidation-dependent protein catabolic process, protein catabolic process, protein quality control for misfolded or incompletely synthesized proteins, protein-containing complex assembly, proteolysis, proteolysis involved in protein catabolic process, response to aluminum ion, response to hormone, response to hypoxia; MF: ADP binding, ATP binding, ATP hydrolysis activity, ATP-dependent peptidase activity, DNA binding, DNA polymerase binding, G-quadruplex DNA binding, PH domain binding, hydrolase activity, identical protein binding, insulin receptor substrate binding, mitochondrial promoter sequence-specific DNA binding, nucleotide binding, peptidase activity, sequence-specific DNA binding, serine-type endopeptidase activity, serine-type peptidase activity, single-stranded DNA binding, single-stranded RNA binding; CC: cytosol, mitochondrial matrix, mitochondrial nucleoid, mitochondrion, nucleoplasm
Pathways: Metabolism of proteins, Mitochondrial protein degradation
UniProt: Q8CGK3
Entrez ID: 74142
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Mrap
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Mrap in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Mrap (melanocortin 2 receptor accessory protein)
Type: protein-coding
Summary: Predicted to enable identical protein binding activity; melanocortin receptor binding activity; and signaling receptor regulator activity. Acts upstream of or within brown fat cell differentiation. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in endoplasmic reticulum and plasma membrane. Is expressed in several structures, including brain; exocrine system; olfactory epithelium; respiratory system; and urinary system. Used to study adrenal gland disease. Human ortholog(s) of this gene implicated in familial glucocorticoid deficiency. Orthologous to human MRAP (melanocortin 2 receptor accessory protein). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: brown fat cell differentiation, negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway, negative regulation of protein localization to plasma membrane, positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway, protein localization to plasma membrane, regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway; MF: corticotropin hormone receptor binding, identical protein binding, signaling receptor regulator activity, type 1 melanocortin receptor binding, type 3 melanocortin receptor binding, type 4 melanocortin receptor binding, type 5 melanocortin receptor binding; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, plasma membrane
Pathways: Cortisol synthesis and secretion - Mus musculus (mouse), Cushing syndrome - Mus musculus (mouse)
UniProt: Q9D159
Entrez ID: 77037
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Elac2
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Elac2 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Elac2 (elaC ribonuclease Z 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial tRNA 3'-end processing, tRNA processing; MF: 3'-tRNA processing endoribonuclease activity, endonuclease activity, hydrolase activity, metal ion binding, nuclease activity, tRNA-specific ribonuclease activity; CC: mitochondrial nucleoid, mitochondrion, nucleoplasm, nucleus
Pathways:
UniProt: Q80Y81
Entrez ID: 68626
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Ncl
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Ncl in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Ncl (nucleolin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: angiogenesis, cellular response to epidermal growth factor stimulus, cellular response to leukemia inhibitory factor, cellular response to lipopolysaccharide, endocytosis, negative regulation of apoptotic process, negative regulation of insulin receptor signaling pathway, negative regulation of translation, positive regulation of interleukin-6 production, positive regulation of mRNA splicing, via spliceosome, positive regulation of macromolecule biosynthetic process, positive regulation of transcription by RNA polymerase II, positive regulation of transcription of nucleolar large rRNA by RNA polymerase I, positive regulation of tumor necrosis factor production, regulation of RNA metabolic process, regulation of gene expression, regulation of rRNA processing; MF: DNA binding, DNA topoisomerase binding, ErbB-4 class receptor binding, PH domain binding, RNA binding, calcium ion binding, histone binding, identical protein binding, insulin receptor substrate binding, laminin binding, mRNA 5'-UTR binding, nucleic acid binding, protein binding, rRNA primary transcript binding, selenocysteine insertion sequence binding, sequence-specific DNA binding, signaling receptor binding, single-stranded DNA binding, telomeric DNA binding; CC: cell cortex, cell surface, chromosome, cornified envelope, cytoplasm, cytoplasmic ribonucleoprotein granule, dense fibrillar component, fibrillar center, nucleolus, nucleoplasm, nucleus, ribonucleoprotein complex, spliceosomal complex
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P09405
Entrez ID: 17975
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Ep300
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Ep300 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Ep300 (E1A binding protein p300)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell differentiation, DNA repair-dependent chromatin remodeling, N-terminal peptidyl-lysine acetylation, TORC1 signaling, TORC2 signaling, animal organ morphogenesis, apoptotic process, autophagosome assembly, behavioral defense response, canonical NF-kappaB signal transduction, canonical Wnt signaling pathway, cartilage development, cell differentiation, cell surface receptor signaling pathway via JAK-STAT, cellular response to L-leucine, cellular response to UV, cellular response to interleukin-1, cellular response to nutrient levels, chromatin remodeling, circadian rhythm, endodermal cell differentiation, face morphogenesis, fat cell differentiation, gluconeogenesis, glycolytic process, heart development, host-mediated activation of viral transcription, internal protein amino acid acetylation, intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, learning or memory, lipid biosynthetic process, lung development, megakaryocyte development, multicellular organism growth, negative regulation of apoptotic signaling pathway, negative regulation of autophagy, negative regulation of chromosome condensation, negative regulation of gluconeogenesis, negative regulation of miRNA metabolic process, negative regulation of protein oligomerization, negative regulation of protein-containing complex assembly, negative regulation of transcription by RNA polymerase II, peptidyl-lysine butyrylation, peptidyl-lysine crotonylation, peptidyl-lysine propionylation, phosphatidylinositol 3-kinase/protein kinase B signal transduction, platelet formation, positive regulation of DNA-binding transcription factor activity, positive regulation of DNA-templated transcription, positive regulation of T-helper 17 cell lineage commitment, positive regulation of TORC1 signaling, positive regulation of TORC2 signaling, positive regulation of axon extension, positive regulation of cell growth, positive regulation of cell growth involved in cardiac muscle cell development, positive regulation of cell size, positive regulation of cellular response to hypoxia, positive regulation of collagen biosynthetic process, positive regulation of gene expression, positive regulation of glycoprotein biosynthetic process, positive regulation of hydrogen peroxide-mediated programmed cell death, positive regulation of muscle atrophy, positive regulation of neuron projection development, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of protein import into nucleus, positive regulation of protein secretion, positive regulation of proteolysis, positive regulation of receptor signaling pathway via JAK-STAT, positive regulation of sarcomere organization, positive regulation of transcription by RNA polymerase II, positive regulation of transforming growth factor beta receptor signaling pathway, positive regulation of translation, protein acetylation, protein destabilization, protein localization to chromatin, protein stabilization, protein-DNA complex assembly, regulation of DNA-templated transcription, regulation of androgen receptor signaling pathway, regulation of angiotensin metabolic process, regulation of glycolytic process, regulation of mitochondrion organization, regulation of transcription by RNA polymerase II, regulation of tubulin deacetylation, response to calcium ion, response to dexamethasone, response to estrogen, response to glucose, response to hypoxia, response to xenobiotic stimulus, rhythmic process, skeletal muscle tissue development, somitogenesis, swimming, thigmotaxis, transcription initiation-coupled chromatin remodeling, tricarboxylic acid metabolic process; MF: DNA binding, DNA-binding transcription factor binding, L-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor, NF-kappaB binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, SMAD binding, STAT family protein binding, acetylation-dependent protein binding, acetyltransferase activity, acyltransferase activity, antigen binding, bHLH transcription factor binding, beta-catenin binding, chromatin DNA binding, chromatin binding, cis-regulatory region sequence-specific DNA binding, damaged DNA binding, histone H1K75 acetyltransferase activity, histone H2B acetyltransferase activity, histone H3 acetyltransferase activity, histone H3K122 acetyltransferase activity, histone H3K18 acetyltransferase activity, histone H3K27 acetyltransferase activity, histone H4 acetyltransferase activity, histone acetyltransferase activity, histone butyryltransferase activity, histone crotonyltransferase activity, histone lactyltransferase (CoA-dependent) activity, histone reader activity, metal ion binding, mitogen-activated protein kinase binding, nuclear androgen receptor binding, nuclear glucocorticoid receptor binding, nuclear receptor binding, p53 binding, peptide 2-hydroxyisobutyryltransferase activity, peptide butyryltransferase activity, peptide crotonyltransferase activity, peptide lactyltransferase (CoA-dependent) activity, peroxisome proliferator activated receptor binding, pre-mRNA intronic binding, promoter-specific chromatin binding, protein antigen binding, protein binding, protein kinase binding, protein propionyltransferase activity, protein-containing complex binding, protein-lysine-acetyltransferase activity, transcription coactivator activity, transcription coactivator binding, transcription coregulator activity, transcription coregulator binding, transferase activity, zinc ion binding; CC: chromatin, cytoplasm, cytosol, histone acetyltransferase complex, nucleoplasm, nucleus, protein-DNA complex, protein-containing complex, transcription regulator complex
Pathways: Activation of the TFAP2 (AP-2) family of transcription factors, Adherens junction - Mus musculus (mouse), Attenuation phase, B-WICH complex positively regulates rRNA expression, C-type lectin receptors (CLRs), CD209 (DC-SIGN) signaling, Cell cycle - Mus musculus (mouse), Cellular response to chemical stress, Cellular response to heat stress, Cellular response to hypoxia, Cellular responses to stimuli, Cellular responses to stress, Cytosolic sensors of pathogen-associated DNA , DDX58/IFIH1-mediated induction of interferon-alpha/beta, Deubiquitination, Developmental Biology, ESR-mediated signaling, Epigenetic regulation of gene expression, Estrogen-dependent gene expression, FOXO-mediated transcription, Formation of the beta-catenin:TCF transactivating complex, FoxO signaling pathway - Mus musculus (mouse), Gene expression (Transcription), Generic Transcription Pathway, Glucagon signaling pathway - Mus musculus (mouse), Growth hormone synthesis, secretion and action - Mus musculus (mouse), HIF-1 signaling pathway - Mus musculus (mouse), HSF1-dependent transactivation, Hepatitis B - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Immune System, Influenza A - Mus musculus (mouse), Innate Immune System, JAK-STAT signaling pathway - Mus musculus (mouse), KEAP1-NFE2L2 pathway, Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production, Long-term potentiation - Mus musculus (mouse), MITF-M-regulated melanocyte development, Melanogenesis - Mus musculus (mouse), Metabolism of proteins, Metalloprotease DUBs, MicroRNAs in cancer - Mus musculus (mouse), NOTCH1 Intracellular Domain Regulates Transcription, NR1H2 and NR1H3-mediated signaling, NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux, Notch signaling pathway - Mus musculus (mouse), Nuclear events mediated by NFE2L2, PI5P Regulates TP53 Acetylation, Pathways in cancer - Mus musculus (mouse), Positive epigenetic regulation of rRNA expression, Post-translational protein modification, Prostate cancer - Mus musculus (mouse), RNA Polymerase II Transcription, RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function, RUNX3 regulates NOTCH signaling, RUNX3 regulates p14-ARF, Regulation of FOXO transcriptional activity by acetylation, Regulation of RUNX3 expression and activity, Regulation of TP53 Activity, Regulation of TP53 Activity through Acetylation, Regulation of TP53 Activity through Methylation, Regulation of gene expression by Hypoxia-inducible Factor, Renal cell carcinoma - Mus musculus (mouse), STAT3 nuclear events downstream of ALK signaling, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of transcription cofactors, Signal Transduction, Signaling by ALK, Signaling by NOTCH, Signaling by NOTCH1, Signaling by Nuclear Receptors, Signaling by Receptor Tyrosine Kinases, Signaling by WNT, TCF dependent signaling in response to WNT, TGF-beta signaling pathway - Mus musculus (mouse), TRAF6 mediated IRF7 activation, Thyroid hormone signaling pathway - Mus musculus (mouse), Transcriptional Regulation by TP53, Transcriptional and post-translational regulation of MITF-M expression and activity, Transcriptional regulation by RUNX1, Transcriptional regulation by RUNX3, Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors, Tuberculosis - Mus musculus (mouse), Viral carcinogenesis - Mus musculus (mouse), Wnt signaling pathway - Mus musculus (mouse), cAMP signaling pathway - Mus musculus (mouse)
UniProt: B2RWS6
Entrez ID: 328572
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Mrps2
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Mrps2 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Mrps2 (mitochondrial ribosomal protein S2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial ribosome assembly, mitochondrial translation, translation; MF: structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial small ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome, small ribosomal subunit
Pathways: Metabolism of proteins, Mitochondrial protein degradation, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Ribosome - Mus musculus (mouse), Translation
UniProt: Q924T2
Entrez ID: 118451
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Kntc1
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Kntc1 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Kntc1 (kinetochore associated 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, mitotic sister chromatid segregation, mitotic spindle assembly checkpoint signaling, protein localization to kinetochore involved in kinetochore assembly; CC: RZZ complex, actin cytoskeleton, chromosome, chromosome, centromeric region, cytoplasm, cytoskeleton, cytosol, kinetochore, kinetochore microtubule, nucleus, plasma membrane, spindle, spindle pole
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, EML4 and NUDC in mitotic spindle formation, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, RHO GTPase Effectors, RHO GTPases Activate Formins, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q8C3Y4
Entrez ID: 208628
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Exosc5
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Exosc5 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Exosc5 (exosome component 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA deamination, RNA catabolic process, RNA processing, U4 snRNA 3'-end processing, defense response to virus, mRNA catabolic process, nuclear mRNA surveillance, poly(A)-dependent snoRNA 3'-end processing, rRNA catabolic process, rRNA processing; MF: DNA binding, RNA binding, molecular_function; CC: cytoplasm, cytoplasmic exosome (RNase complex), cytosol, euchromatin, exosome (RNase complex), nuclear exosome (RNase complex), nucleolar exosome (RNase complex), nucleolus, nucleoplasm, nucleus
Pathways: Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA, Deadenylation-dependent mRNA decay, KSRP (KHSRP) binds and destabilizes mRNA, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Nuclear RNA decay, RNA degradation - Mus musculus (mouse), Regulation of mRNA stability by proteins that bind AU-rich elements, Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA, mRNA decay by 3' to 5' exoribonuclease, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9CRA8
Entrez ID: 27998
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Gm3488
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Gm3488 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Gm3488 (predicted gene, 3488)
Type: protein-coding
Summary: predicted gene, 3488
Gene Ontology:
Pathways:
UniProt: M0QW81
Entrez ID: 100041735
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Snrpf
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Snrpf in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Snrpf (small nuclear ribonucleoprotein polypeptide F)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, mRNA processing, mRNA splicing, via spliceosome, protein-RNA complex assembly, spliceosomal snRNP assembly; MF: RNA binding; CC: SMN-Sm protein complex, U1 snRNP, U12-type spliceosomal complex, U2-type catalytic step 2 spliceosome, U2-type precatalytic spliceosome, U2-type spliceosomal complex, U4 snRNP, U4/U6 x U5 tri-snRNP complex, U7 snRNP, catalytic step 2 spliceosome, cytoplasm, cytosol, methylosome, nucleus, pICln-Sm protein complex, ribonucleoprotein complex, small nuclear ribonucleoprotein complex, spliceosomal complex
Pathways: Gene expression (Transcription), Metabolism of RNA, Metabolism of non-coding RNA, Processing of Capped Intron-Containing Pre-mRNA, Processing of Capped Intronless Pre-mRNA, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs, SLBP independent Processing of Histone Pre-mRNAs, Spliceosome - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway, mRNA Splicing - Minor Pathway, snRNP Assembly
UniProt: P62307
Entrez ID: 69878
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Ndufb9
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Ndufb9 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Ndufb9 (NADH:ubiquinone oxidoreductase subunit B9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: aerobic respiration, mitochondrial electron transport, NADH to ubiquinone, proton motive force-driven mitochondrial ATP synthesis; CC: membrane, mitochondrial inner membrane, mitochondrion, respiratory chain complex I
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Complex I biogenesis, Diabetic cardiomyopathy - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Metabolism, NADH to cytochrome <i>bd</i> oxidase electron transfer I, NADH to cytochrome <i>bo</i> oxidase electron transfer I, Non-alcoholic fatty liver disease - Mus musculus (mouse), Oxidative phosphorylation - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Respiratory electron transport, Retrograde endocannabinoid signaling - Mus musculus (mouse), Thermogenesis - Mus musculus (mouse), aerobic respiration -- electron donor II
UniProt: Q9CQJ8
Entrez ID: 66218
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Rps23
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Rps23 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Rps23 (ribosomal protein S23)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translation, maintenance of translational fidelity, ribosomal small subunit biogenesis, stress granule assembly, translation; MF: protein binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, endoplasmic reticulum, nucleolus, nucleus, postsynapse, ribonucleoprotein complex, ribosome, rough endoplasmic reticulum, small ribosomal subunit, small-subunit processome, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Post-translational protein modification, Protein hydroxylation, Ribosomal scanning and start codon recognition, Ribosome - Mus musculus (mouse), Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, Translation initiation complex formation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62267
Entrez ID: 66475
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Cryzl1
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Cryzl1 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Cryzl1 (crystallin zeta like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: identical protein binding, oxidoreductase activity; CC: early endosome, endosome
Pathways:
UniProt: Q921W4
Entrez ID: 66609
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Rabggtb
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Rabggtb in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Rabggtb (Rab geranylgeranyl transferase, b subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: endoplasmic reticulum to Golgi vesicle-mediated transport, protein geranylgeranylation; MF: Rab geranylgeranyltransferase activity, catalytic activity, isoprenoid binding, metal ion binding, prenyltransferase activity, protein binding, protein geranylgeranyltransferase activity, protein prenyltransferase activity, small GTPase binding, transferase activity, zinc ion binding; CC: Rab-protein geranylgeranyltransferase complex, cytoplasm
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Metabolism of proteins, Post-translational protein modification, RAB geranylgeranylation, RNA Polymerase II Transcription, TP53 Regulates Transcription of Cell Death Genes, TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain, Transcriptional Regulation by TP53
UniProt: P53612
Entrez ID: 19352
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Nhlrc2
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Nhlrc2 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Nhlrc2 (NHL repeat containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cytoplasm, cytosol
Pathways: Hemostasis, Platelet activation, signaling and aggregation, Platelet degranulation , Response to elevated platelet cytosolic Ca2+, arsenate detoxification I (glutaredoxin)
UniProt: Q8BZW8
Entrez ID: 66866
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Eif4h
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Eif4h in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Eif4h (eukaryotic translation initiation factor 4H)
Type: protein-coding
Summary: This gene encodes eukaryotic translation initiation factor 4H (eIF4H) that plays a critical role in the process of protein synthesis. The encoded protein is an RNA-binding protein that, in concert with other translation initiation factors, helps unwind the 5' cap-proximal region of mRNA to prepare it for ribosomal attachment. Mice lacking the encoded protein displayed growth retardation with a significant reduction of body weight, a smaller brain volume and altered brain morphology. Behaviorally, mice lacking the encoded protein exhibit severe impairments of fear-related associative learning and memory formation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015].
Gene Ontology: BP: developmental growth, eukaryotic translation initiation factor 4F complex assembly, formation of translation preinitiation complex, translation, translational initiation; MF: RNA binding, RNA strand annealing activity, RNA strand-exchange activity, nucleic acid binding, ribosomal small subunit binding, translation initiation factor activity; CC: cytoplasm, perinuclear region of cytoplasm
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Eukaryotic Translation Initiation, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Metabolism of proteins, Ribosomal scanning and start codon recognition, Translation, Translation initiation complex formation
UniProt: Q9WUK2
Entrez ID: 22384
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Nme6
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Nme6 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Nme6 (NME/NM23 nucleoside diphosphate kinase 6)
Type: protein-coding
Summary: Predicted to enable nucleoside diphosphate kinase activity. Predicted to be involved in negative regulation of cell growth and negative regulation of mitotic nuclear division. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system; nervous system; and sensory organ. Orthologous to human NME6 (NME/NM23 nucleoside diphosphate kinase 6). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: CTP biosynthetic process, GTP biosynthetic process, UTP biosynthetic process, negative regulation of cell growth, negative regulation of mitotic nuclear division, nucleotide metabolic process, pyrimidine ribonucleotide salvage; MF: ATP binding, kinase activity, metal ion binding, nucleoside diphosphate kinase activity, nucleotide binding, transferase activity; CC: mitochondrial inner membrane, mitochondrial matrix, mitochondrion
Pathways: Drug metabolism - other enzymes - Mus musculus (mouse), Purine metabolism - Mus musculus (mouse), Pyrimidine metabolism - Mus musculus (mouse), adenosine nucleotides <i>de novo</i> biosynthesis, pyrimidine deoxyribonucleotides <i>de novo</i> biosynthesis I, pyrimidine ribonucleotides <i>de novo</i> biosynthesis, pyrimidine ribonucleotides interconversion, salvage pathways of pyrimidine ribonucleotides
UniProt: O88425
Entrez ID: 54369
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Rhod
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Rhod in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Rhod (ras homolog family member D)
Type: protein-coding
Summary: Enables GTP binding activity and protein kinase binding activity. Involved in regulation of actin cytoskeleton organization and regulation of focal adhesion assembly. Acts upstream of or within several processes, including actin filament polymerization; fibroblast growth factor receptor signaling pathway; and protein targeting. Is active in cell projection. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human RHOD (ras homolog family member D). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: actin filament bundle assembly, actin filament organization, actin filament polymerization, cell migration, cell projection assembly, fibroblast growth factor receptor signaling pathway, focal adhesion assembly, lamellipodium assembly, positive regulation of cell adhesion, positive regulation of cell migration, protein targeting, regulation of actin cytoskeleton organization, regulation of focal adhesion assembly, response to fibroblast growth factor, signal transduction, small GTPase-mediated signal transduction; MF: GTP binding, GTPase activity, nucleotide binding, protein binding, protein kinase binding; CC: cell projection, cytosol, early endosome, endosome, membrane, plasma membrane
Pathways: Axon guidance - Mus musculus (mouse), RHO GTPase Effectors, RHO GTPase cycle, RHO GTPases Activate Formins, RHOD GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: P97348
Entrez ID: 11854
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Nup188
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Nup188 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Nup188 (nucleoporin 188)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA export from nucleus, mRNA transport, nucleocytoplasmic transport, protein import into nucleus, protein transport; MF: structural constituent of nuclear pore; CC: nuclear envelope, nuclear pore, nuclear pore inner ring, nucleus
Pathways: Amyotrophic lateral sclerosis - Mus musculus (mouse), Cell Cycle, Cell Cycle, Mitotic, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Gene Silencing by RNA, Gene expression (Transcription), Glucose metabolism, Glycolysis, IP3 and IP4 transport between cytosol and nucleus, IP6 and IP7 transport between cytosol and nucleus, IPs transport between nucleus and cytosol, Inositol phosphate metabolism, M Phase, Metabolism, Metabolism of RNA, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of non-coding RNA, Metabolism of proteins, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prophase, Nuclear Envelope (NE) Reassembly, Nuclear Envelope Breakdown, Nuclear Pore Complex (NPC) Disassembly, Nucleocytoplasmic transport - Mus musculus (mouse), Post-translational protein modification, Postmitotic nuclear pore complex (NPC) reformation, Processing of Capped Intron-Containing Pre-mRNA, Regulation of Glucokinase by Glucokinase Regulatory Protein, Regulation of HSF1-mediated heat shock response, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, SUMOylation of DNA replication proteins, SUMOylation of RNA binding proteins, SUMOylation of SUMOylation proteins, SUMOylation of chromatin organization proteins, SUMOylation of ubiquitinylation proteins, Transcriptional regulation by small RNAs, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNA derived from an Intron-Containing Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, Transport of the SLBP Dependant Mature mRNA, Transport of the SLBP independent Mature mRNA, snRNP Assembly
UniProt: Q6ZQH8
Entrez ID: 227699
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Fads2
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Fads2 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Fads2 (fatty acid desaturase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: alpha-linolenic acid metabolic process, arachidonate metabolite production involved in inflammatory response, fatty acid biosynthetic process, fatty acid derivative biosynthetic process, fatty acid metabolic process, linoleic acid metabolic process, lipid metabolic process, long-chain fatty acid biosynthetic process, positive regulation of cellular response to oxidative stress, unsaturated fatty acid biosynthetic process; MF: acyl-CoA 6-desaturase activity, acyl-CoA desaturase activity, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water, stearoyl-CoA 9-desaturase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Biosynthesis of unsaturated fatty acids - Mus musculus (mouse), Fatty acid metabolism, Linoleic acid (LA) metabolism, Metabolism, Metabolism of lipids, PPAR signaling pathway - Mus musculus (mouse), alpha-Linolenic acid metabolism - Mus musculus (mouse), alpha-linolenic (omega3) and linoleic (omega6) acid metabolism, alpha-linolenic acid (ALA) metabolism, oleate biosynthesis II (animals)
UniProt: Q9Z0R9
Entrez ID: 56473
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Rpn2
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Rpn2 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Rpn2 (ribophorin II)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein N-linked glycosylation, protein glycosylation; MF: protein binding, ribosome binding; CC: autophagosome membrane, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, nuclear body, oligosaccharyltransferase complex, oligosaccharyltransferase complex A, oligosaccharyltransferase complex B
Pathways: Adaptive Immune System, Adherens junctions interactions, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Co-inhibition by PD-1, Immune System, N-Glycan biosynthesis - Mus musculus (mouse), PD-L1(CD274) glycosylation and translocation to plasma membrane, Protein processing in endoplasmic reticulum - Mus musculus (mouse), Regulation of CDH1 Expression and Function, Regulation of CDH1 posttranslational processing and trafficking to plasma membrane, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of T cell activation by CD28 family, Various types of N-glycan biosynthesis - Mus musculus (mouse)
UniProt: Q9DBG6
Entrez ID: 20014
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Usp16
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Usp16 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Usp16 (ubiquitin specific peptidase 16)
Type: protein-coding
Summary: Enables histone H2A deubiquitinase activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; early embryo; genitourinary system; nervous system; and sensory organ. Orthologous to human USP16 (ubiquitin specific peptidase 16). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: DNA damage response, cell division, chromatin organization, chromatin remodeling, mitotic cell cycle, mitotic nuclear division, monoubiquitinated protein deubiquitination, positive regulation of DNA-templated transcription, positive regulation of ribosome biogenesis, positive regulation of transcription by RNA polymerase II, positive regulation of translational elongation, protein deubiquitination, protein homotetramerization, proteolysis, regulation of cell cycle, regulation of gene expression, regulation of transcription by RNA polymerase II; MF: cysteine-type deubiquitinase activity, cysteine-type endopeptidase activity, cysteine-type peptidase activity, histone H2A deubiquitinase activity, histone binding, hydrolase activity, metal ion binding, peptidase activity, protein binding, ribosomal small subunit binding, transcription coactivator activity, ubiquitin binding, zinc ion binding; CC: cytoplasm, nucleus
Pathways: Deubiquitination, Metabolism of proteins, Post-translational protein modification, Ub-specific processing proteases
UniProt: Q99LG0
Entrez ID: 74112
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Zbtb14
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Zbtb14 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Zbtb14 (zinc finger and BTB domain containing 14)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cardiac septum development, coronary vasculature development, heart valve development, kidney development, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, regulation of cytokine production, regulation of immune system process; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding, zinc ion binding; CC: aggresome, cytosol, nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: Q08376
Entrez ID: 22666
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Lrrc10
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Lrrc10 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Lrrc10 (leucine rich repeat containing 10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cardiac muscle cell development; MF: actin binding, alpha-actinin binding; CC: cytoskeleton, mitochondrion, myofibril, nucleus, sarcomere
Pathways:
UniProt: Q8K3W2
Entrez ID: 237560
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Vmn1r11
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Vmn1r11 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Vmn1r11 (vomeronasal 1 receptor 11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled receptor activity, pheromone binding, pheromone receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: A0A2I3BRK7, Q3SXA2
Entrez ID: 113860
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Sec22b
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Sec22b in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Sec22b (SEC22 homolog B, vesicle trafficking protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: endoplasmic reticulum to Golgi vesicle-mediated transport, negative regulation of autophagosome assembly, positive regulation of protein catabolic process, protein transport, retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum, vesicle fusion with Golgi apparatus, vesicle-mediated transport; MF: SNAP receptor activity, protein binding, syntaxin binding; CC: COPI-coated vesicle, ER to Golgi transport vesicle membrane, Golgi apparatus, Golgi membrane, SNARE complex, cytoplasm, endomembrane system, endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum-Golgi intermediate compartment, endoplasmic reticulum-Golgi intermediate compartment membrane, melanosome, membrane, synaptic vesicle
Pathways: Adaptive Immune System, Antigen processing-Cross presentation, Asparagine N-linked glycosylation, COPI-dependent Golgi-to-ER retrograde traffic, COPII-mediated vesicle transport, Cargo concentration in the ER, Class I MHC mediated antigen processing & presentation, ER to Golgi Anterograde Transport, ER-Phagosome pathway, Golgi-to-ER retrograde transport, Immune System, Intra-Golgi and retrograde Golgi-to-ER traffic, Legionellosis - Mus musculus (mouse), Membrane Trafficking, Metabolism of proteins, Phagosome - Mus musculus (mouse), Post-translational protein modification, SNARE interactions in vesicular transport - Mus musculus (mouse), Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: O08547
Entrez ID: 20333
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Pgam1
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Pgam1 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Pgam1 (phosphoglycerate mutase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: canonical glycolysis, gluconeogenesis, glyceraldehyde-3-phosphate biosynthetic process, glycolytic process; MF: bisphosphoglycerate mutase activity, catalytic activity, hydrolase activity, intramolecular phosphotransferase activity, isomerase activity, phosphoglycerate mutase activity, protein kinase binding; CC: cytoplasm, cytosol, myelin sheath, sperm principal piece
Pathways: Central carbon metabolism in cancer - Mus musculus (mouse), Glucagon signaling pathway - Mus musculus (mouse), Gluconeogenesis, Glucose metabolism, Glycine, serine and threonine metabolism - Mus musculus (mouse), Glycolysis, Glycolysis / Gluconeogenesis - Mus musculus (mouse), Immune System, Innate Immune System, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Neutrophil degranulation, Rapoport-Luebering glycolytic shunt, gluconeogenesis I, glycolysis I, glycolysis III, glycolysis V (Pyrococcus)
UniProt: Q9DBJ1
Entrez ID: 18648
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Pa2g4
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Pa2g4 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Pa2g4 (proliferation-associated 2G4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of DNA-templated transcription, negative regulation of apoptotic process, positive regulation of cell differentiation, rRNA processing, regulation of translation; MF: RNA binding, nucleic acid binding, transcription corepressor activity, ubiquitin protein ligase binding; CC: cytoplasm, nucleolus, nucleus, ribonucleoprotein complex
Pathways: Immune System, Innate Immune System, Neutrophil degranulation
UniProt: P50580
Entrez ID: 18813
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Sel1l
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Sel1l in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Sel1l (sel-1 suppressor of lin-12-like (C. elegans))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ERAD pathway, Notch signaling pathway, protein secretion, protein transport, response to endoplasmic reticulum stress, retrograde protein transport, ER to cytosol, triglyceride metabolic process; CC: Derlin-1 retrotranslocation complex, Hrd1p ubiquitin ligase ERAD-L complex, Hrd1p ubiquitin ligase complex, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), Adaptive Immune System, Co-inhibition by PD-1, Hedgehog ligand biogenesis, Immune System, Protein processing in endoplasmic reticulum - Mus musculus (mouse), Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of T cell activation by CD28 family, Signal Transduction, Signaling by Hedgehog, Transport of small molecules
UniProt: Q9Z2G6
Entrez ID: 20338
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Mrpl12
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Mrpl12 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Mrpl12 (mitochondrial ribosomal protein L12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial transcription, mitochondrial translation, positive regulation of DNA-templated transcription, translation; MF: mRNA binding, structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrial matrix, mitochondrial ribosome, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial protein degradation, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Ribosome - Mus musculus (mouse), Translation
UniProt: Q9DB15
Entrez ID: 56282
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
C4b
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of C4b in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: C4b (complement C4B (Chido blood group))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: complement activation, complement activation, GZMK pathway, complement activation, classical pathway, complement activation, lectin pathway, immune system process, immunoglobulin mediated immune response, inflammatory response, innate immune response; MF: antigen binding, carbohydrate binding, complement binding, complement component C1q complex binding, endopeptidase inhibitor activity; CC: axon, cell surface, classical-complement-pathway C3/C5 convertase complex, dendrite, extracellular region, extracellular space, neuronal cell body, symbiont cell surface, synapse
Pathways: Activation of C3 and C5, Alcoholic liver disease - Mus musculus (mouse), Complement and coagulation cascades - Mus musculus (mouse), Complement cascade, Coronavirus disease - COVID-19 - Mus musculus (mouse), Immune System, Initial triggering of complement, Innate Immune System, Metabolism of proteins, Pertussis - Mus musculus (mouse), Post-translational protein modification, Post-translational protein phosphorylation, Regulation of Complement cascade, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Staphylococcus aureus infection - Mus musculus (mouse), Systemic lupus erythematosus - Mus musculus (mouse)
UniProt: P01029
Entrez ID: 12268
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Nfx1
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Nfx1 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Nfx1 (nuclear transcription factor, X-box binding 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of MHC class II biosynthetic process, negative regulation of transcription by RNA polymerase II, protein autoubiquitination; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, metal ion binding, nucleic acid binding, protein binding, transferase activity, ubiquitin protein ligase activity, zinc ion binding; CC: cytosol, nucleolus, nucleoplasm, nucleus, plasma membrane
Pathways: Human papillomavirus infection - Mus musculus (mouse)
UniProt: B1AY10
Entrez ID: 74164
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Pacsin1
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Pacsin1 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Pacsin1 (protein kinase C and casein kinase substrate in neurons 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin filament organization, cytoskeleton organization, endocytosis, negative regulation of endocytosis, neuron development, neuron projection morphogenesis, plasma membrane tubulation, positive regulation of dendrite development, protein localization to membrane, protein localization to plasma membrane, regulation of endocytosis, regulation of postsynaptic neurotransmitter receptor internalization, signal transduction, synaptic vesicle endocytosis; MF: cytoskeletal protein binding, identical protein binding, lipid binding, phospholipid binding, protein binding; CC: COPI-coated vesicle, axon terminus, cell projection, cytoplasm, cytoplasmic vesicle, cytoplasmic vesicle membrane, cytosol, endosome, glutamatergic synapse, membrane, myelin sheath, neuron projection, perinuclear region of cytoplasm, photoreceptor ribbon synapse, plasma membrane, postsynaptic density membrane, presynaptic endocytic zone, ruffle membrane, synapse
Pathways: Clathrin-mediated endocytosis, Membrane Trafficking, Vesicle-mediated transport
UniProt: Q61644
Entrez ID: 23969
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Pofut2
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Pofut2 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Pofut2 (protein O-fucosyltransferase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: fucose metabolic process, mesoderm formation, positive regulation of protein folding, protein O-linked glycosylation via fucose, protein glycosylation, regulation of epithelial to mesenchymal transition, regulation of gene expression, regulation of secretion; MF: fucosyltransferase activity, glycosyltransferase activity, peptide-O-fucosyltransferase activity, transferase activity; CC: Golgi apparatus, endoplasmic reticulum, endoplasmic reticulum membrane
Pathways: Metabolism of proteins, O-glycosylation of TSR domain-containing proteins, O-linked glycosylation, Other types of O-glycan biosynthesis - Mus musculus (mouse), Post-translational protein modification
UniProt: Q8VHI3
Entrez ID: 80294
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Trim34b
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Trim34b in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Trim34b (tripartite motif-containing 34B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: defense response to virus, innate immune response, protein ubiquitination, regulation of gene expression; MF: identical protein binding, metal ion binding, transferase activity, ubiquitin protein ligase activity, zinc ion binding; CC: cytoplasm, mitochondrion
Pathways:
UniProt: K7N6K2
Entrez ID: 434218
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Timmdc1
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Timmdc1 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Timmdc1 (translocase of inner mitochondrial membrane domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, mitochondrial respiratory chain complex I assembly; CC: membrane, mitochondrial membrane, mitochondrion, nucleoplasm
Pathways: Aerobic respiration and respiratory electron transport, Complex I biogenesis, Metabolism, Respiratory electron transport
UniProt: Q8BUY5
Entrez ID: 76916
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
H2-T3
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of H2-T3 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: H2-T3 (histocompatibility 2, T region locus 3)
Type: protein-coding
Summary: Predicted to enable several functions, including beta-2-microglobulin binding activity; peptide antigen binding activity; and signaling receptor binding activity. Predicted to be involved in several processes, including antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent; antigen processing and presentation of endogenous peptide antigen via MHC class Ib; and positive regulation of T cell mediated cytotoxicity. Predicted to be located in several cellular components, including Golgi apparatus; cell surface; and endoplasmic reticulum. Predicted to be part of MHC class I protein complex and MHC class Ib protein complex. Predicted to be active in external side of plasma membrane and extracellular space. Is expressed in small intestine and thymus. [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent, antigen processing and presentation of endogenous peptide antigen via MHC class Ib, antigen processing and presentation of peptide antigen via MHC class I, immune response, immune system process, positive regulation of T cell mediated cytotoxicity; MF: peptide antigen binding, signaling receptor binding; CC: MHC class I protein complex, external side of plasma membrane, extracellular space, lumenal side of endoplasmic reticulum membrane, membrane, phagocytic vesicle membrane
Pathways: Allograft rejection - Mus musculus (mouse), Antigen processing and presentation - Mus musculus (mouse), Autoimmune thyroid disease - Mus musculus (mouse), Cell adhesion molecules - Mus musculus (mouse), Cellular senescence - Mus musculus (mouse), Endocytosis - Mus musculus (mouse), Epstein-Barr virus infection - Mus musculus (mouse), Graft-versus-host disease - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Phagosome - Mus musculus (mouse), Type I diabetes mellitus - Mus musculus (mouse), Viral carcinogenesis - Mus musculus (mouse), Viral myocarditis - Mus musculus (mouse)
UniProt: Q8HWB4, Q05A75, G3UZR8, F6TIX5, S4R2A2, G3UZL7, S4R1D6, S4R2B8
Entrez ID: 15043
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Yeats4
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Yeats4 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Yeats4 (YEATS domain containing 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, chromatin remodeling, positive regulation of DNA-templated transcription, positive regulation of double-strand break repair via homologous recombination, regulation of DNA-templated transcription, regulation of apoptotic process, regulation of cell cycle, regulation of double-strand break repair, regulation of transcription by RNA polymerase II; MF: histone H3K18ac reader activity, histone H3K27ac reader activity, histone binding, protein binding; CC: NuA4 histone acetyltransferase complex, nuclear membrane, nucleoplasm, nucleosome, nucleus
Pathways: Activation of the TFAP2 (AP-2) family of transcription factors, Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription, Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
UniProt: Q9CR11
Entrez ID: 64050
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Zfp534
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Zfp534 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Zfp534 (zinc finger protein 534)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: nucleus
Pathways: Herpes simplex virus 1 infection - Mus musculus (mouse)
UniProt: A2A7A1
Entrez ID: 100503584
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Spc24
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Spc24 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Spc24 (SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: attachment of spindle microtubules to kinetochore, cell division, chromosome segregation, mitotic spindle assembly checkpoint signaling; CC: Ndc80 complex, chromosome, chromosome, centromeric region, kinetochore, nucleolus, nucleoplasm, nucleus, outer kinetochore
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, EML4 and NUDC in mitotic spindle formation, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, RHO GTPase Effectors, RHO GTPases Activate Formins, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q9D083
Entrez ID: 67629
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Axin1
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Axin1 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Axin1 (axin 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Wnt signaling pathway, apoptotic process, axial mesoderm development, axial mesoderm formation, beta-catenin destruction complex assembly, canonical Wnt signaling pathway, cell development, cytoplasmic microtubule organization, dorsal/ventral axis specification, dorsal/ventral pattern formation, epigenetic programming in the zygotic pronuclei, head development, in utero embryonic development, negative regulation of Wnt signaling pathway, negative regulation of canonical Wnt signaling pathway, negative regulation of fat cell differentiation, negative regulation of gene expression, negative regulation of protein metabolic process, negative regulation of transcription elongation by RNA polymerase II, nucleocytoplasmic transport, positive regulation of JNK cascade, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of protein catabolic process, positive regulation of protein kinase activity, positive regulation of protein ubiquitination, positive regulation of transforming growth factor beta receptor signaling pathway, positive regulation of ubiquitin-dependent protein catabolic process, post-anal tail morphogenesis, proteasome-mediated ubiquitin-dependent protein catabolic process, protein catabolic process, protein polyubiquitination, protein-containing complex assembly, regulation of canonical Wnt signaling pathway, sensory perception of sound; MF: I-SMAD binding, R-SMAD binding, SMAD binding, armadillo repeat domain binding, beta-catenin binding, enzyme binding, identical protein binding, molecular adaptor activity, p53 binding, protein binding, protein domain specific binding, protein homodimerization activity, protein kinase binding, protein serine/threonine kinase activator activity, protein serine/threonine kinase binding, signaling adaptor activity, signaling receptor binding, ubiquitin protein ligase binding, ubiquitin-like ligase-substrate adaptor activity; CC: Golgi apparatus, Wnt signalosome, beta-catenin destruction complex, cell cortex, cell periphery, cytoplasm, cytoplasmic vesicle, cytosol, lateral plasma membrane, membrane, microtubule cytoskeleton, nucleolus, nucleus, perinuclear region of cytoplasm, plasma membrane, protein-containing complex, synapse
Pathways: Alzheimer disease - Mus musculus (mouse), Basal cell carcinoma - Mus musculus (mouse), Beta-catenin phosphorylation cascade, Breast cancer - Mus musculus (mouse), Colorectal cancer - Mus musculus (mouse), Cushing syndrome - Mus musculus (mouse), Degradation of AXIN, Degradation of beta-catenin by the destruction complex, Deubiquitination, Disassembly of the destruction complex and recruitment of AXIN to the membrane, Endometrial cancer - Mus musculus (mouse), Gastric cancer - Mus musculus (mouse), Hepatocellular carcinoma - Mus musculus (mouse), Hippo signaling pathway - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Metabolism of proteins, Pathways in cancer - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Post-translational protein modification, Signal Transduction, Signaling by WNT, Signaling pathways regulating pluripotency of stem cells - Mus musculus (mouse), TCF dependent signaling in response to WNT, Ub-specific processing proteases, Wnt signaling pathway - Mus musculus (mouse)
UniProt: O35625
Entrez ID: 12005
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Donson
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Donson in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Donson (downstream neighbor of SON)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage checkpoint signaling, DNA replication, mitotic DNA replication checkpoint signaling, mitotic G2 DNA damage checkpoint signaling, nuclear DNA replication, replication fork processing; CC: nucleus, replication fork, replisome
Pathways:
UniProt: Q9QXP4
Entrez ID: 60364
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Rps28
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Rps28 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Rps28 (ribosomal protein S28)
Type: protein-coding
Summary: A structural constituent of ribosome. Predicted to be involved in cytoplasmic translation; maturation of SSU-rRNA; and ribosomal small subunit assembly. Part of cytosolic small ribosomal subunit. Is active in synapse. Is expressed in several structures, including cardiovascular system; extraembryonic component; genitourinary system; hemolymphoid system; and vitelline vein. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 15 with mandibulofacial dysostosis. Orthologous to human RPS28 (ribosomal protein S28). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cytoplasmic translation, maturation of SSU-rRNA, rRNA processing, ribosomal small subunit assembly, ribosomal small subunit biogenesis, ribosome biogenesis, translation, translation at postsynapse, translation at presynapse; MF: structural constituent of ribosome; CC: cytoplasm, cytoplasmic side of rough endoplasmic reticulum membrane, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, endoplasmic reticulum, nucleolus, nucleus, postsynapse, presynapse, ribonucleoprotein complex, ribosome, rough endoplasmic reticulum, small-subunit processome, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosomal scanning and start codon recognition, Ribosome - Mus musculus (mouse), Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, Translation initiation complex formation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62858
Entrez ID: 54127
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Ssrp1
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Ssrp1 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Ssrp1 (structure specific recognition protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, DNA replication, nucleosome assembly, nucleosome disassembly, regulation of chromatin organization; MF: DNA binding, chromatin binding, histone binding, nucleosome binding; CC: FACT complex, chromosome, nucleolus, nucleus
Pathways: Formation of RNA Pol II elongation complex , Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, TP53 Regulates Transcription of DNA Repair Genes, Transcriptional Regulation by TP53
UniProt: Q08943
Entrez ID: 20833
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Rhox3e
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Rhox3e in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Rhox3e (reproductive homeobox 3E)
Type: protein-coding
Summary: Orthologous to human RHOXF2B (Rhox homeobox family member 2B). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology:
Pathways:
UniProt: V9GX94, Q4TU90, V9GXY5, V9GXK5, V9GWU0, V9GXD0, V9GXQ1
Entrez ID: 100135657
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Gnl3
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Gnl3 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Gnl3 (guanine nucleotide binding protein nucleolar 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of miRNA transcription, positive regulation of protein localization to chromosome, telomeric region, positive regulation of protein sumoylation, positive regulation of telomere maintenance, regulation of cell population proliferation, stem cell division, stem cell population maintenance; MF: GTP binding, mRNA 5'-UTR binding, nucleotide binding, protein binding; CC: chromosome, midbody, nuclear body, nucleolus, nucleoplasm, nucleus
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Ribosome biogenesis in eukaryotes - Mus musculus (mouse), rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q8CI11
Entrez ID: 30877
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Tmem201
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Tmem201 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Tmem201 (transmembrane protein 201)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: angiogenesis, centrosome localization, fibroblast migration, nuclear envelope organization, nuclear migration, nuclear migration along microtubule, positive regulation of endothelial cell migration, protein localization to nuclear envelope; MF: actin filament binding, lamin binding, protein binding; CC: cortical endoplasmic reticulum, membrane, nuclear envelope, nuclear inner membrane, nuclear membrane, nucleus, spindle pole centrosome
Pathways:
UniProt: A2A8U2
Entrez ID: 230917
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Pwp2
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Pwp2 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Pwp2 (PWP2 periodic tryptophan protein homolog (yeast))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), ribosomal small subunit assembly, ribosomal small subunit biogenesis; CC: Pwp2p-containing subcomplex of 90S preribosome, nucleolus, nucleus, small-subunit processome
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Ribosome biogenesis in eukaryotes - Mus musculus (mouse), rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q8BU03
Entrez ID: 110816
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Ddx52
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Ddx52 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Ddx52 (DExD box helicase 52)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: maturation of SSU-rRNA; MF: ATP binding, ATP hydrolysis activity, RNA binding, RNA helicase activity, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding; CC: nucleolus, nucleus
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q8K301
Entrez ID: 78394
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Eif2s2
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Eif2s2 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Eif2s2 (eukaryotic translation initiation factor 2 subunit 2 beta)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translational initiation, formation of translation preinitiation complex, in utero embryonic development, male germ cell proliferation, male gonad development, translation, translational initiation; MF: mRNA binding, metal ion binding, protein binding, translation initiation factor activity, translation initiation factor binding, zinc ion binding; CC: cytoplasm, cytosol, eukaryotic translation initiation factor 2 complex, synapse
Pathways: ABC-family proteins mediated transport, Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Cellular response to mitochondrial stress, Cellular responses to stimuli, Cellular responses to stress, Eukaryotic Translation Initiation, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Metabolism of proteins, PERK regulates gene expression, Recycling of eIF2:GDP, Ribosomal scanning and start codon recognition, Translation, Translation initiation complex formation, Transport of small molecules, Unfolded Protein Response (UPR)
UniProt: Q99L45
Entrez ID: 67204
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Mbd3
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Mbd3 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Mbd3 (methyl-CpG binding domain protein 3)
Type: protein-coding
Summary: This gene encodes a member of the MBD family of nuclear proteins that contain a methyl-CpG binding domain (MBD). The encoded protein is a component of the nucleosome remodeling and histone deacetylation (NuRD) complex. Deletion of this gene causes embryonic lethality in mice. Embryonic stem cells lacking the encoded protein are severely compromised in their ability to differentiate and fail to commit to developmental lineages in the absence of leukemia inhibitory factor. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015].
Gene Ontology: BP: DNA methylation-dependent constitutive heterochromatin formation, chromatin remodeling, embryonic organ development, epigenetic regulation of gene expression, in utero embryonic development, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, regulation of cell fate specification, regulation of stem cell differentiation, response to bisphenol A, response to estradiol, response to nutrient levels, tissue development, ventricular cardiac muscle tissue development; MF: DNA binding, methyl-CpG binding, protein binding; CC: NuRD complex, chromatin, chromosome, cytoplasm, heterochromatin, histone deacetylase complex, nucleoplasm, nucleus, protein-containing complex
Pathways:
UniProt: Q9Z2D8
Entrez ID: 17192
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Ubl5
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Ubl5 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Ubl5 (ubiquitin-like 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mRNA splicing, via spliceosome, protein modification process; CC: cytoplasm, nucleus
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q9EPV8
Entrez ID: 66177
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Rps25
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Rps25 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Rps25 (ribosomal protein S25)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translation, rRNA processing, ribosomal small subunit biogenesis; MF: structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, nucleolus, nucleus, postsynaptic density, ribonucleoprotein complex, ribosome, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosomal scanning and start codon recognition, Ribosome - Mus musculus (mouse), Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, Translation initiation complex formation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62852
Entrez ID: 75617
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Yrdc
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Yrdc in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Yrdc (yrdC domain containing (E.coli))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of transport, regulation of translational fidelity, tRNA threonylcarbamoyladenosine modification; MF: L-threonylcarbamoyladenylate synthase, double-stranded RNA binding, nucleotidyltransferase activity, protein binding, tRNA binding, transferase activity; CC: cytoplasm, membrane, mitochondrion, plasma membrane
Pathways: Metabolism of RNA, tRNA modification in the mitochondrion, tRNA processing
UniProt: Q3U5F4
Entrez ID: 230734
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Asns
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Asns in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Asns (asparagine synthetase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: L-asparagine biosynthetic process, amino acid biosynthetic process, asparagine biosynthetic process, cellular response to glucose starvation, negative regulation of apoptotic process, positive regulation of mitotic cell cycle; MF: ATP binding, asparagine synthase (glutamine-hydrolyzing) activity, identical protein binding, ligase activity, nucleotide binding; CC: cytosol
Pathways: Alanine, aspartate and glutamate metabolism - Mus musculus (mouse), Aspartate and asparagine metabolism, Metabolism, Metabolism of amino acids and derivatives, asparagine biosynthesis I
UniProt: Q61024
Entrez ID: 27053
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Pdcd10
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Pdcd10 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Pdcd10 (programmed cell death 10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi reassembly, angiogenesis, apoptotic process, cellular response to anoxia, cellular response to leukemia inhibitory factor, endothelium development, establishment of Golgi localization, intracellular signal transduction, intrinsic apoptotic signaling pathway in response to hydrogen peroxide, negative regulation of apoptotic process, negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis, negative regulation of cell migration involved in sprouting angiogenesis, negative regulation of gene expression, negative regulation of inflammatory response, positive regulation of MAP kinase activity, positive regulation of Notch signaling pathway, positive regulation of cell migration, positive regulation of cell population proliferation, positive regulation of gene expression, positive regulation of intracellular protein transport, positive regulation of mesenchymal cell apoptotic process, positive regulation of stress-activated MAPK cascade, protein stabilization, regulation of angiogenesis, short-term memory, wound healing, spreading of cells; MF: protein binding, protein homodimerization activity, protein kinase binding; CC: FAR/SIN/STRIPAK complex, Golgi apparatus, Golgi membrane, cell periphery, cytoplasm, cytosol, membrane, plasma membrane
Pathways:
UniProt: Q8VE70
Entrez ID: 56426
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Pfdn5
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Pfdn5 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Pfdn5 (prefoldin 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA polymerase I assembly, RNA polymerase II core complex assembly, RNA polymerase III assembly, negative regulation of DNA-templated transcription, negative regulation of amyloid fibril formation, negative regulation of canonical Wnt signaling pathway, protein folding, retina development in camera-type eye; MF: amyloid-beta binding, unfolded protein binding; CC: cytoplasm, cytosol, intermediate filament cytoskeleton, nucleus, prefoldin complex
Pathways:
UniProt: Q9WU28
Entrez ID: 56612
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Mrpl4
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Mrpl4 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Mrpl4 (mitochondrial ribosomal protein L4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial translation, translation; MF: structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Ribosome - Mus musculus (mouse), Translation
UniProt: Q9DCU6
Entrez ID: 66163
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Sds
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Sds in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Sds (serine dehydratase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: L-serine catabolic process, amino acid metabolic process, gluconeogenesis, lipid metabolic process, protein-containing complex assembly, pyruvate biosynthetic process, small molecule biosynthetic process; MF: L-serine ammonia-lyase activity, lyase activity, protein homodimerization activity, pyridoxal phosphate binding, threonine deaminase activity; CC: cytoplasm, cytosol, mitochondrion
Pathways: Cysteine and methionine metabolism - Mus musculus (mouse), Glycine, serine and threonine metabolism - Mus musculus (mouse), L-serine degradation, Metabolism, Metabolism of amino acids and derivatives, Serine metabolism, Threonine catabolism, Valine, leucine and isoleucine biosynthesis - Mus musculus (mouse), glycine betaine degradation
UniProt: Q8VBT2
Entrez ID: 231691
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Mrps33
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Mrps33 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Mrps33 (mitochondrial ribosomal protein S33)
Type: protein-coding
Summary: Predicted to be involved in mitochondrial translation. Located in mitochondrion. Is expressed in several structures, including early conceptus; gonad; liver; salivary gland; and spleen. Orthologous to human MRPS33 (mitochondrial ribosomal protein S33). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: CC: mitochondrial inner membrane, mitochondrial small ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Translation
UniProt: Q9D2R8
Entrez ID: 14548
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Frs2
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Frs2 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Frs2 (fibroblast growth factor receptor substrate 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: anterior/posterior axis specification, embryo, cell surface receptor protein tyrosine kinase signaling pathway, cellular response to fibroblast growth factor stimulus, fibroblast growth factor receptor signaling pathway, forebrain development, gastrulation with mouth forming second, lens development in camera-type eye, lens fiber cell development, lens placode formation involved in camera-type eye formation, negative regulation of cardiac muscle cell differentiation, neuroblast proliferation, organ induction, positive regulation of MAPK cascade, positive regulation of vascular associated smooth muscle cell proliferation, prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis, regulation of ERK1 and ERK2 cascade, regulation of apoptotic process, regulation of epithelial cell proliferation, ventricular septum development; MF: fibroblast growth factor receptor binding, neurotrophin TRKA receptor binding, protein binding, transmembrane receptor protein tyrosine kinase adaptor activity; CC: adherens junction, cell-cell junction, cytoplasm, cytosol, membrane, plasma membrane
Pathways: Activated NTRK2 signals through FRS2 and FRS3, Axon guidance, Developmental Biology, Downstream signaling of activated FGFR1, Downstream signaling of activated FGFR2, Downstream signaling of activated FGFR3, Downstream signaling of activated FGFR4, FRS-mediated FGFR1 signaling, FRS-mediated FGFR2 signaling, FRS-mediated FGFR3 signaling, FRS-mediated FGFR4 signaling, Frs2-mediated activation, IGF1R signaling cascade, IRS-mediated signalling, IRS-related events triggered by IGF1R, Insulin receptor signalling cascade, Intracellular signaling by second messengers, MAPK family signaling cascades, MAPK1/MAPK3 signaling, Negative regulation of FGFR1 signaling, Negative regulation of FGFR2 signaling, Negative regulation of FGFR3 signaling, Negative regulation of FGFR4 signaling, Negative regulation of the PI3K/AKT network, Nervous system development, Neurotrophin signaling pathway - Mus musculus (mouse), PI-3K cascade:FGFR1, PI-3K cascade:FGFR2, PI-3K cascade:FGFR3, PI-3K cascade:FGFR4, PI3K Cascade, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, PIP3 activates AKT signaling, Prolonged ERK activation events, Proteoglycans in cancer - Mus musculus (mouse), RAF/MAP kinase cascade, RET signaling, RHO GTPase cycle, RND1 GTPase cycle, RND2 GTPase cycle, Signal Transduction, Signaling by FGFR, Signaling by FGFR1, Signaling by FGFR2, Signaling by FGFR3, Signaling by FGFR4, Signaling by Insulin receptor, Signaling by NTRK1 (TRKA), Signaling by NTRK2 (TRKB), Signaling by NTRKs, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), Signalling to ERKs, Thermogenesis - Mus musculus (mouse)
UniProt: Q8C180
Entrez ID: 327826
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Krtap10-4
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Krtap10-4 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Krtap10-4 (keratin associated protein 10-4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: identical protein binding, molecular_function; CC: cellular_component, cytosol, intermediate filament, keratin filament
Pathways: Developmental Biology, Keratinization
UniProt: Q08EG8
Entrez ID: 100191037
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Vmn1r79
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Vmn1r79 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Vmn1r79 (vomeronasal 1 receptor 79)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, biological_process, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled receptor activity, molecular_function, pheromone binding, pheromone receptor activity; CC: cellular_component, membrane, plasma membrane
Pathways:
UniProt: Q8R285
Entrez ID: 100042437
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Isca1
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Isca1 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Isca1 (iron-sulfur cluster assembly 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: iron-sulfur cluster assembly, protein maturation; MF: 2 iron, 2 sulfur cluster binding, iron-sulfur cluster binding, metal ion binding; CC: cytoplasm, mitochondrial [4Fe-4S] assembly complex, mitochondrion
Pathways: Aerobic respiration and respiratory electron transport, Citric acid cycle (TCA cycle), Maturation of TCA enzymes and regulation of TCA cycle, Metabolism, Mitochondrial iron-sulfur cluster biogenesis
UniProt: Q9D924
Entrez ID: 69046
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Zfp652
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Zfp652 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Zfp652 (zinc finger protein 652)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding
Pathways:
UniProt: Q5DU09
Entrez ID: 268469
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Atxn2
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Atxn2 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Atxn2 (ataxin 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: P-body assembly, cerebellar Purkinje cell differentiation, homeostasis of number of cells, negative regulation of multicellular organism growth, negative regulation of receptor internalization, neuromuscular process, neuron projection morphogenesis, stress granule assembly; MF: RNA binding, epidermal growth factor receptor binding, mRNA binding; CC: Golgi apparatus, cytoplasm, cytoplasmic stress granule, cytosol, perinuclear region of cytoplasm, ribonucleoprotein complex, trans-Golgi network
Pathways: Amyotrophic lateral sclerosis - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Spinocerebellar ataxia - Mus musculus (mouse)
UniProt: O70305
Entrez ID: 20239
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Psma1
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Psma1 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Psma1 (proteasome subunit alpha 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: immune system process, negative regulation of inflammatory response to antigenic stimulus, proteasome-mediated ubiquitin-dependent protein catabolic process, proteolysis involved in protein catabolic process, ubiquitin-dependent protein catabolic process; MF: lipopolysaccharide binding, protein binding; CC: centrosome, cytoplasm, cytosol, nucleoplasm, nucleus, proteasome complex, proteasome core complex, proteasome core complex, alpha-subunit complex
Pathways: ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, AUF1 (hnRNP D0) binds and destabilizes mRNA, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Activation of NF-kappaB in B cells, Adaptive Immune System, Adherens junctions interactions, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Antigen processing-Cross presentation, Antigen processing: Ub, ATP-independent proteasomal degradation, Antigen processing: Ubiquitination & Proteasome degradation, Assembly of the pre-replicative complex, Asymmetric localization of PCP proteins, Autodegradation of Cdh1 by Cdh1:APC/C, Autodegradation of the E3 ubiquitin ligase COP1, Beta-catenin independent WNT signaling, C-type lectin receptors (CLRs), CDK-mediated phosphorylation and removal of Cdc6, CLEC7A (Dectin-1) signaling, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cellular response to chemical stress, Cellular response to hypoxia, Cellular responses to stimuli, Cellular responses to stress, Circadian clock, Class I MHC mediated antigen processing & presentation, Co-inhibition by PD-1, Cross-presentation of soluble exogenous antigens (endosomes), Cyclin A:Cdk2-associated events at S phase entry, Cyclin E associated events during G1/S transition , Cytokine Signaling in Immune system, DNA Replication, DNA Replication Pre-Initiation, Dectin-1 mediated noncanonical NF-kB signaling, Degradation of AXIN, Degradation of CDH1, Degradation of CRY and PER proteins, Degradation of DVL, Degradation of GLI1 by the proteasome, Degradation of beta-catenin by the destruction complex, Deubiquitination, Downstream TCR signaling, Downstream signaling events of B Cell Receptor (BCR), ER-Phagosome pathway, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, FCERI mediated NF-kB activation, Fc epsilon receptor (FCERI) signaling, G1/S DNA Damage Checkpoints, G1/S Transition, G2/M Checkpoints, G2/M Transition, GLI3 is processed to GLI3R by the proteasome, GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2, GSK3B-mediated proteasomal degradation of PD-L1(CD274), Gene expression (Transcription), Generic Transcription Pathway, Hedgehog 'off' state, Hedgehog 'on' state, Hedgehog ligand biogenesis, Huntington disease - Mus musculus (mouse), Immune System, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, Intracellular signaling by second messengers, KEAP1-NFE2L2 pathway, M Phase, MAPK family signaling cascades, MAPK1/MAPK3 signaling, MAPK6/MAPK4 signaling, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of polyamines, Metabolism of proteins, Mitotic Anaphase, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, NIK-->noncanonical NF-kB signaling, Neddylation, Nuclear events mediated by NFE2L2, Orc1 removal from chromatin, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, PCP/CE pathway, PIP3 activates AKT signaling, PTEN Regulation, Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Post-translational protein modification, Prion disease - Mus musculus (mouse), Proteasome - Mus musculus (mouse), Proteasome assembly, RAF/MAP kinase cascade, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of PTEN stability and activity, Regulation of RAS by GAPs, Regulation of RUNX2 expression and activity, Regulation of RUNX3 expression and activity, Regulation of T cell activation by CD28 family, Regulation of mRNA stability by proteins that bind AU-rich elements, Regulation of mitotic cell cycle, Regulation of ornithine decarboxylase (ODC), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, S Phase, SCF(Skp2)-mediated degradation of p27/p21, SPOP-mediated proteasomal degradation of PD-L1(CD274), Separation of Sister Chromatids, Signal Transduction, Signaling by Hedgehog, Signaling by Interleukins, Signaling by WNT, Signaling by the B Cell Receptor (BCR), Spinocerebellar ataxia - Mus musculus (mouse), Stabilization of p53, Switching of origins to a post-replicative state, Synthesis of DNA, TCF dependent signaling in response to WNT, TCR signaling, TNFR2 non-canonical NF-kB pathway, Targeted protein degradation, The role of GTSE1 in G2/M progression after G2 checkpoint, Transcriptional regulation by RUNX1, Transcriptional regulation by RUNX2, Transcriptional regulation by RUNX3, Translation, Transport of small molecules, UCH proteinases, Ub-specific processing proteases, Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, Ubiquitin-dependent degradation of Cyclin D, p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint, p53-Independent G1/S DNA Damage Checkpoint
UniProt: Q9R1P4
Entrez ID: 26440
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Slc25a32
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Slc25a32 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Slc25a32 (solute carrier family 25, member 32)
Type: protein-coding
Summary: Enables FAD transmembrane transporter activity. Involved in mitochondrial FAD transmembrane transport. Located in mitochondrion. Is expressed in embryo; metencephalon floor plate; and skeletal muscle. Orthologous to human SLC25A32 (solute carrier family 25 member 32). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: folate import into mitochondrion, mitochondrial FAD transmembrane transport, mitochondrial transmembrane transport, nucleotide transport, organic anion transport, transmembrane transport; MF: FAD transmembrane transporter activity, folic acid transmembrane transporter activity; CC: membrane, mitochondrial inner membrane, mitochondrion
Pathways: Metabolism, Metabolism of folate and pterines, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors
UniProt: Q8BMG8
Entrez ID: 69906
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Dhrs7b
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Dhrs7b in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Dhrs7b (dehydrogenase/reductase 7B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adipose tissue development, brown fat cell differentiation, ether lipid biosynthetic process, fat cell differentiation, inflammatory response, negative regulation of DNA-templated transcription, neutrophil differentiation, phosphatidylcholine biosynthetic process, regulation of DNA-templated transcription, regulation of cold-induced thermogenesis, regulation of gene expression; MF: DNA-binding transcription factor binding, acylglycerone-phosphate reductase (NADP+) activity, oxidoreductase activity, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, protein binding, transcription corepressor activity; CC: cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, nucleus, peroxisomal membrane, peroxisome, transcription regulator complex
Pathways: Metabolism, Metabolism of lipids, Plasmalogen biosynthesis, Wax and plasmalogen biosynthesis
UniProt: Q99J47
Entrez ID: 216820
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Rpl32
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Rpl32 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Rpl32 (ribosomal protein L32)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to dexamethasone stimulus, cytoplasmic translation, liver regeneration, translation, translation at postsynapse, translation at presynapse; MF: structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, postsynapse, presynapse, ribonucleoprotein complex, ribosome, synapse
Pathways: Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosome - Mus musculus (mouse), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62911
Entrez ID: 19951
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Trmu
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Trmu in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Trmu (tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: tRNA processing, tRNA wobble position uridine thiolation; MF: ATP binding, RNA binding, nucleotide binding, sulfurtransferase activity, tRNA binding, tRNA-5-taurinomethyluridine 2-sulfurtransferase, transferase activity; CC: mitochondrion
Pathways:
UniProt: Q9DAT5
Entrez ID: 72026
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Zbtb26
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Zbtb26 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Zbtb26 (zinc finger and BTB domain containing 26)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of transcription by RNA polymerase II, regulation of cytokine production, regulation of immune system process; MF: DNA binding, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, identical protein binding, metal ion binding, sequence-specific double-stranded DNA binding, zinc ion binding; CC: nucleoplasm, nucleus
Pathways:
UniProt: Q8C8S0, Q6P9Q3
Entrez ID: 320633
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Kctd4
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Kctd4 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Kctd4 (potassium channel tetramerisation domain containing 4)
Type: protein-coding
Summary: Predicted to be involved in protein homooligomerization. Is expressed in cerebral cortex subventricular zone; cortical plate; midbrain; and periaqueductal grey. Orthologous to human KCTD4 (potassium channel tetramerization domain containing 4). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: biological_process, protein homooligomerization
Pathways:
UniProt: Q9D7X1
Entrez ID: 67516
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Gramd4
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Gramd4 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Gramd4 (GRAM domain containing 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, negative regulation of toll-like receptor 9 signaling pathway, positive regulation of apoptotic process; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, mitochondrial membrane, mitochondrion
Pathways:
UniProt: Q8CB44
Entrez ID: 223752
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Rrp15
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Rrp15 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Rrp15 (ribosomal RNA processing 15 homolog)
Type: protein-coding
Summary: This gene encodes a protein similar to budding yeast Rrp15p. Rrp15p is a component of pre-60S ribosomal particles in budding yeast, and is required for the early maturation steps of the 60S subunit. The mouse genome contains at least one pseudogene on the X chromosome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: maturation of 5.8S rRNA, maturation of LSU-rRNA, rRNA processing
Pathways:
UniProt: Q9CYX7
Entrez ID: 67223
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Foxn2
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Foxn2 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Foxn2 (forkhead box N2)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity and cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within skeletal muscle cell differentiation. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including branchial arch; genitourinary system; jaw; limb bud; and nervous system. Orthologous to human FOXN2 (forkhead box N2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: regulation of DNA-templated transcription, skeletal muscle cell differentiation; MF: DNA binding, DNA-binding transcription factor activity, cis-regulatory region sequence-specific DNA binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: nucleoplasm, nucleus
Pathways:
UniProt: E9Q7L6, Q8BSS2, D3Z6Z3, E9PYQ6
Entrez ID: 14236
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Fanca
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Fanca in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Fanca (Fanconi anemia, complementation group A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, female gonad development, interstrand cross-link repair, male gonad development, male meiotic nuclear division, regulation of CD40 signaling pathway, regulation of germ cell proliferation, regulation of inflammatory response, regulation of regulatory T cell differentiation; CC: Fanconi anaemia nuclear complex, chromatin, cytoplasm, nucleoplasm, nucleus
Pathways: Antiviral mechanism by IFN-stimulated genes, Cytokine Signaling in Immune system, DNA Repair, Fanconi Anemia Pathway, Fanconi anemia pathway - Mus musculus (mouse), Immune System, Interferon Signaling, PKR-mediated signaling
UniProt: Q9JL70
Entrez ID: 14087
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Mrps18b
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Mrps18b in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Mrps18b (mitochondrial ribosomal protein S18B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial translation, translation; MF: structural constituent of ribosome; CC: cell junction, mitochondrial inner membrane, mitochondrial small ribosomal subunit, mitochondrion, nucleoplasm, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Translation, Viral carcinogenesis - Mus musculus (mouse)
UniProt: Q99N84
Entrez ID: 66973
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Mis12
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Mis12 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Mis12 (MIS12 kinetochore complex component)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: attachment of mitotic spindle microtubules to kinetochore, attachment of spindle microtubules to kinetochore, cell division, chromosome segregation, kinetochore assembly, mitotic cell cycle, mitotic sister chromatid segregation; CC: MIS12/MIND type complex, chromosome, chromosome, centromeric region, kinetochore, nucleus, outer kinetochore, spindle pole
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, EML4 and NUDC in mitotic spindle formation, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, RHO GTPase Effectors, RHO GTPases Activate Formins, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q9CY25
Entrez ID: 67139
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Mycbp
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Mycbp in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Mycbp (MYC binding protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of DNA-templated transcription, regulation of DNA-templated transcription; MF: transcription coactivator activity; CC: cytoplasm, mitochondrion, nucleoplasm, nucleus
Pathways:
UniProt: Q9EQS3
Entrez ID: 56309
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Rbm27
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Rbm27 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Rbm27 (RNA binding motif protein 27)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: RNA binding, metal ion binding, nucleic acid binding, zinc ion binding; CC: cytoplasm, nuclear speck, nucleus
Pathways: Metabolism of RNA, Nuclear RNA decay
UniProt: Q5SFM8
Entrez ID: 225432
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Ufm1
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Ufm1 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Ufm1 (ubiquitin-fold modifier 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: brain development, negative regulation of apoptotic process, negative regulation of protein import into nucleus, protein K69-linked ufmylation, protein ufmylation, regulation of intracellular estrogen receptor signaling pathway, response to endoplasmic reticulum stress, reticulophagy; CC: cytoplasm, endoplasmic reticulum, nucleus
Pathways:
UniProt: P61961
Entrez ID: 67890
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Tex19.1
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Tex19.1 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Tex19.1 (testis expressed gene 19.1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, cell proliferation involved in embryonic placenta development, homologous chromosome pairing at meiosis, in utero embryonic development, male gonad development, male meiotic nuclear division, meiotic cell cycle, placenta development, post-transcriptional regulation of gene expression, reciprocal meiotic recombination, spermatogenesis, spongiotrophoblast cell proliferation, transposable element silencing; MF: RNA binding, piRNA binding, protein binding; CC: cytoplasm, nucleus
Pathways:
UniProt: Q99MV2
Entrez ID: 73679
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Mical2
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Mical2 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Mical2 (microtubule associated monooxygenase, calponin and LIM domain containing 2)
Type: protein-coding
Summary: Enables several functions, including NAD(P)H oxidase H2O2-forming activity; actin binding activity; and mitogen-activated protein kinase binding activity. Involved in actin filament depolymerization and sulfur oxidation. Located in cytoplasm. Is expressed in cortical plate; lower jaw molar; and upper jaw molar. Orthologous to human MICAL2 (microtubule associated monooxygenase, calponin and LIM domain containing 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: actin filament depolymerization, cytoskeleton organization, heart development, heart looping, positive regulation of transcription by RNA polymerase II, sulfur oxidation; MF: F-actin monooxygenase activity, FAD binding, NAD(P)H oxidase H2O2-forming activity, actin binding, metal ion binding, mitogen-activated protein kinase binding, monooxygenase activity, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen; CC: actin filament, cytoplasm, nucleus
Pathways:
UniProt: Q8BML1
Entrez ID: 320878
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Kdm1a
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Kdm1a in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Kdm1a (lysine (K)-specific demethylase 1A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA repair-dependent chromatin remodeling, cell differentiation, cellular response to UV, cellular response to gamma radiation, chromatin organization, epigenetic regulation of gene expression, epithelial to mesenchymal transition, granulocyte differentiation, guanine metabolic process, muscle cell development, negative regulation of DNA damage response, signal transduction by p53 class mediator, negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator, negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, negative regulation of neurogenesis, negative regulation of transcription by RNA polymerase II, negative regulation of transcription initiation-coupled chromatin remodeling, neuron projection extension, neuron projection morphogenesis, pituitary gland development, positive regulation of cell differentiation, positive regulation of cold-induced thermogenesis, positive regulation of epithelial to mesenchymal transition, positive regulation of erythrocyte differentiation, positive regulation of megakaryocyte differentiation, positive regulation of multicellular organismal process, positive regulation of neural precursor cell proliferation, positive regulation of neuroblast proliferation, positive regulation of protein ubiquitination, positive regulation of stem cell proliferation, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of double-strand break repair via homologous recombination, regulation of neurogenesis, regulation of primitive erythrocyte differentiation, regulation of protein localization, regulation of transcription by RNA polymerase II; MF: DNA-binding transcription factor binding, FAD-dependent H3K4me/H3K4me3 demethylase activity, MRF binding, RNA binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, chromatin binding, enzyme binding, flavin adenine dinucleotide binding, histone H3K4 demethylase activity, histone H3K9 demethylase activity, histone H3K9me2/H3K9me3 demethylase activity, histone demethylase activity, identical protein binding, lncRNA binding, nuclear androgen receptor binding, oxidoreductase activity, p53 binding, promoter-specific chromatin binding, protein binding, protein demethylase activity, telomeric repeat-containing RNA binding, transcription coactivator activity, transcription corepressor activity; CC: DNA repair complex, chromatin, chromosome, chromosome, telomeric region, histone methyltransferase complex, nucleoplasm, nucleus, protein-containing complex
Pathways: Adherens junctions interactions, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Chromatin modifying enzymes, Chromatin organization, ESR-mediated signaling, Estrogen-dependent gene expression, Factors involved in megakaryocyte development and platelet production, HDACs deacetylate histones, HDMs demethylate histones, Hemostasis, Negative Regulation of CDH1 Gene Transcription, Regulation of CDH1 Expression and Function, Regulation of CDH1 Gene Transcription, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Signal Transduction, Signaling by Nuclear Receptors, Thermogenesis - Mus musculus (mouse)
UniProt: Q6ZQ88
Entrez ID: 99982
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Mecr
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Mecr in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Mecr (mitochondrial trans-2-enoyl-CoA reductase)
Type: protein-coding
Summary: Predicted to enable enoyl-[acyl-carrier-protein] reductase (NADPH) activity; nuclear receptor binding activity; and signaling receptor binding activity. Predicted to be involved in fatty acid metabolic process. Located in mitochondrion. Is expressed in submandibular gland primordium. Human ortholog(s) of this gene implicated in childhood-onset dystonia with optic atrophy and basal ganglia abnormalities and optic atrophy. Orthologous to human MECR (mitochondrial trans-2-enoyl-CoA reductase). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: ceramide biosynthetic process, fatty acid biosynthetic process, fatty acid metabolic process, intracellular iron ion homeostasis, lipid metabolic process; MF: enoyl-[acyl-carrier-protein] reductase (NADPH) activity, nuclear receptor binding, oxidoreductase activity, signaling receptor binding; CC: cytosol, membrane, mitochondrion, nucleus
Pathways: Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA, Fatty acid biosynthesis - Mus musculus (mouse), Fatty acid elongation - Mus musculus (mouse), Fatty acid metabolism, Metabolism, Metabolism of lipids, Mitochondrial Fatty Acid Beta-Oxidation, mitochondrial fatty acid beta-oxidation of saturated fatty acids, very long chain fatty acid biosynthesis
UniProt: Q9DCS3
Entrez ID: 26922
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Psma5
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Psma5 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Psma5 (proteasome subunit alpha 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: proteasome-mediated ubiquitin-dependent protein catabolic process, proteolysis involved in protein catabolic process, ubiquitin-dependent protein catabolic process; CC: cytoplasm, cytosol, nucleoplasm, nucleus, proteasome complex, proteasome core complex, proteasome core complex, alpha-subunit complex
Pathways: ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, AUF1 (hnRNP D0) binds and destabilizes mRNA, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Activation of NF-kappaB in B cells, Adaptive Immune System, Adherens junctions interactions, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Antigen processing-Cross presentation, Antigen processing: Ub, ATP-independent proteasomal degradation, Antigen processing: Ubiquitination & Proteasome degradation, Assembly of the pre-replicative complex, Asymmetric localization of PCP proteins, Autodegradation of Cdh1 by Cdh1:APC/C, Autodegradation of the E3 ubiquitin ligase COP1, Beta-catenin independent WNT signaling, C-type lectin receptors (CLRs), CDK-mediated phosphorylation and removal of Cdc6, CLEC7A (Dectin-1) signaling, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cellular response to chemical stress, Cellular response to hypoxia, Cellular responses to stimuli, Cellular responses to stress, Circadian clock, Class I MHC mediated antigen processing & presentation, Co-inhibition by PD-1, Cross-presentation of soluble exogenous antigens (endosomes), Cyclin A:Cdk2-associated events at S phase entry, Cyclin E associated events during G1/S transition , Cytokine Signaling in Immune system, DNA Replication, DNA Replication Pre-Initiation, Dectin-1 mediated noncanonical NF-kB signaling, Degradation of AXIN, Degradation of CDH1, Degradation of CRY and PER proteins, Degradation of DVL, Degradation of GLI1 by the proteasome, Degradation of beta-catenin by the destruction complex, Deubiquitination, Downstream TCR signaling, Downstream signaling events of B Cell Receptor (BCR), ER-Phagosome pathway, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, FCERI mediated NF-kB activation, Fc epsilon receptor (FCERI) signaling, G1/S DNA Damage Checkpoints, G1/S Transition, G2/M Checkpoints, G2/M Transition, GLI3 is processed to GLI3R by the proteasome, GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2, GSK3B-mediated proteasomal degradation of PD-L1(CD274), Gene expression (Transcription), Generic Transcription Pathway, Hedgehog 'off' state, Hedgehog 'on' state, Hedgehog ligand biogenesis, Huntington disease - Mus musculus (mouse), Immune System, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, Intracellular signaling by second messengers, KEAP1-NFE2L2 pathway, M Phase, MAPK family signaling cascades, MAPK1/MAPK3 signaling, MAPK6/MAPK4 signaling, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of polyamines, Metabolism of proteins, Mitotic Anaphase, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, NIK-->noncanonical NF-kB signaling, Neddylation, Neutrophil degranulation, Nuclear events mediated by NFE2L2, Orc1 removal from chromatin, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, PCP/CE pathway, PIP3 activates AKT signaling, PTEN Regulation, Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Post-translational protein modification, Prion disease - Mus musculus (mouse), Proteasome - Mus musculus (mouse), Proteasome assembly, RAF/MAP kinase cascade, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of PTEN stability and activity, Regulation of RAS by GAPs, Regulation of RUNX2 expression and activity, Regulation of RUNX3 expression and activity, Regulation of T cell activation by CD28 family, Regulation of mRNA stability by proteins that bind AU-rich elements, Regulation of mitotic cell cycle, Regulation of ornithine decarboxylase (ODC), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, S Phase, SCF(Skp2)-mediated degradation of p27/p21, SPOP-mediated proteasomal degradation of PD-L1(CD274), Separation of Sister Chromatids, Signal Transduction, Signaling by Hedgehog, Signaling by Interleukins, Signaling by WNT, Signaling by the B Cell Receptor (BCR), Spinocerebellar ataxia - Mus musculus (mouse), Stabilization of p53, Switching of origins to a post-replicative state, Synthesis of DNA, TCF dependent signaling in response to WNT, TCR signaling, TNFR2 non-canonical NF-kB pathway, Targeted protein degradation, The role of GTSE1 in G2/M progression after G2 checkpoint, Transcriptional regulation by RUNX1, Transcriptional regulation by RUNX2, Transcriptional regulation by RUNX3, Translation, Transport of small molecules, UCH proteinases, Ub-specific processing proteases, Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, Ubiquitin-dependent degradation of Cyclin D, p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint, p53-Independent G1/S DNA Damage Checkpoint
UniProt: Q9Z2U1
Entrez ID: 26442
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Farsb
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Farsb in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Farsb (phenylalanyl-tRNA synthetase, beta subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: phenylalanyl-tRNA aminoacylation, protein heterotetramerization, translation; MF: ATP binding, RNA binding, aminoacyl-tRNA ligase activity, ligase activity, magnesium ion binding, metal ion binding, nucleotide binding, phenylalanine-tRNA ligase activity; CC: cytoplasm, phenylalanine-tRNA ligase complex
Pathways: Aminoacyl-tRNA biosynthesis - Mus musculus (mouse), tRNA charging pathway
UniProt: Q9WUA2
Entrez ID: 23874
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Slbp
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Slbp in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Slbp (stem-loop binding protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cap-dependent translational initiation, mRNA 3'-end processing by stem-loop binding and cleavage, mRNA processing, mRNA transport; MF: RNA binding, histone pre-mRNA stem-loop binding, identical protein binding, mRNA binding, protein binding; CC: cytoplasm, cytosol, histone mRNA stem-loop binding complex, histone pre-mRNA 3'end processing complex, nucleolus, nucleoplasm, nucleus, ribonucleoprotein complex
Pathways: Gene expression (Transcription), Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Processing of Capped Intronless Pre-mRNA, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNAs Derived from Intronless Transcripts, Transport of the SLBP Dependant Mature mRNA
UniProt: P97440
Entrez ID: 20492
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Asb3
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Asb3 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Asb3 (ankyrin repeat and SOCS box-containing 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, establishment or maintenance of cell polarity, intracellular signal transduction, protein ubiquitination, regulation of Wnt signaling pathway
Pathways:
UniProt: Q9WV72
Entrez ID: 65257
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Aco2
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Aco2 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Aco2 (aconitase 2, mitochondrial)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: citrate metabolic process, isocitrate metabolic process, tricarboxylic acid cycle; MF: 3 iron, 4 sulfur cluster binding, 4 iron, 4 sulfur cluster binding, aconitate hydratase activity, iron ion binding, iron-sulfur cluster binding, lyase activity, metal ion binding; CC: cytosol, mitochondrial matrix, mitochondrion, myelin sheath
Pathways: Aerobic respiration and respiratory electron transport, Citrate cycle (TCA cycle) - Mus musculus (mouse), Citric acid cycle (TCA cycle), Glyoxylate and dicarboxylate metabolism - Mus musculus (mouse), Maturation of TCA enzymes and regulation of TCA cycle, Metabolism, Metabolism of proteins, Mitochondrial protein degradation, TCA cycle, TCA cycle variation III (eukaryotic)
UniProt: Q99KI0
Entrez ID: 11429
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Mup9
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Mup9 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Mup9 (major urinary protein 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: P02762
Entrez ID: 100038948
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Nop2
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Nop2 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Nop2 (NOP2 nucleolar protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA methylation, RNA processing, blastocyst formation, maturation of LSU-rRNA, methylation, rRNA base methylation, rRNA processing, regulation of signal transduction by p53 class mediator, ribosomal large subunit assembly, ribosomal large subunit biogenesis, ribosome biogenesis; MF: RNA binding, RNA methyltransferase activity, S-adenosylmethionine-dependent methyltransferase activity, methyltransferase activity, rRNA (cytosine-C5-)-methyltransferase activity, transferase activity; CC: nucleolus, nucleus
Pathways:
UniProt: A0A0N4SW16, E9QN31
Entrez ID: 110109
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Mdn1
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Mdn1 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Mdn1 (midasin AAA ATPase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ribosomal large subunit assembly, ribosome biogenesis; MF: ATP binding, ATP hydrolysis activity, molecular_function, nucleotide binding; CC: cytosol, intermediate filament cytoskeleton, nucleolus, nucleoplasm, nucleus
Pathways: Ribosome biogenesis in eukaryotes - Mus musculus (mouse)
UniProt: A2ANY6, J3QMC5
Entrez ID: 100019
|
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