screen_file
string | organism
string | perturbation
string | gene
string | cell
string | phenotype
string | hit
int64 | benchmark_type
string | prompt
string | gene_context
string |
|---|---|---|---|---|---|---|---|---|---|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Ctcf
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Ctcf in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Ctcf (CCCTC-binding factor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA methylation-dependent constitutive heterochromatin formation, cardiac muscle cell development, cardiac muscle cell differentiation, chromatin looping, chromatin organization, chromosome segregation, epigenetic regulation of gene expression, gene expression, genomic imprinting, heart development, in utero embryonic development, mitochondrion organization, negative regulation of DNA-templated transcription, negative regulation of cell population proliferation, negative regulation of gene expression, negative regulation of gene expression via chromosomal CpG island methylation, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of gene expression, positive regulation of macromolecule biosynthetic process, positive regulation of miRNA transcription, positive regulation of transcription by RNA polymerase II, protein localization to chromosome, centromeric region, random inactivation of X chromosome, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor binding, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, chromatin binding, chromatin insulator sequence binding, chromatin loop anchoring activity, cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding, transcription coregulator binding, zinc ion binding; CC: chromosome, chromosome, centromeric region, condensed chromosome, dense fibrillar component, granular component, male germ cell nucleus, nucleolus, nucleoplasm, nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription
UniProt: Q61164
Entrez ID: 13018
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Foxk2
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Foxk2 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Foxk2 (forkhead box K2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: canonical glycolysis, intracellular glucose homeostasis, negative regulation of DNA-templated transcription, negative regulation of autophagy, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of glucose metabolic process, regulation of transcription by RNA polymerase II, response to starvation; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, magnesium ion binding, metal ion binding, protein binding, sequence-specific DNA binding, transcription cis-regulatory region binding; CC: cytoplasm, mitochondrion, nucleoplasm, nucleus
Pathways: Deubiquitination, Metabolism of proteins, Post-translational protein modification, UCH proteinases
UniProt: Q3UCQ1
Entrez ID: 68837
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Taf1c
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Taf1c in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Taf1c (TATA-box binding protein associated factor, RNA polymerase I, C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA polymerase I preinitiation complex assembly, transcription by RNA polymerase I; MF: DNA binding, RNA polymerase I core promoter sequence-specific DNA binding, RNA polymerase I general transcription initiation factor activity, protein binding; CC: RNA polymerase I transcription regulator complex, RNA polymerase transcription factor SL1 complex, fibrillar center, nucleolus, nucleoplasm, nucleus
Pathways: B-WICH complex positively regulates rRNA expression, Epigenetic regulation of gene expression, Gene expression (Transcription), Positive epigenetic regulation of rRNA expression, RNA Polymerase I Promoter Clearance, RNA Polymerase I Promoter Escape, RNA Polymerase I Transcription, RNA Polymerase I Transcription Initiation, RNA Polymerase I Transcription Termination
UniProt: Q6PDZ2
Entrez ID: 21341
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Scd2
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Scd2 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Scd2 (stearoyl-Coenzyme A desaturase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: fatty acid biosynthetic process, fatty acid metabolic process, lipid metabolic process, monounsaturated fatty acid biosynthetic process, response to fatty acid, unsaturated fatty acid biosynthetic process; MF: acyl-CoA desaturase activity, iron ion binding, metal ion binding, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water, palmitoyl-CoA 9-desaturase activity, stearoyl-CoA 9-desaturase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, nucleolus
Pathways: AMPK signaling pathway - Mus musculus (mouse), Alcoholic liver disease - Mus musculus (mouse), Biosynthesis of unsaturated fatty acids - Mus musculus (mouse), Fatty acid metabolism, Fatty acyl-CoA biosynthesis, Metabolism, Metabolism of lipids, PPAR signaling pathway - Mus musculus (mouse), oleate biosynthesis II (animals)
UniProt: P13011
Entrez ID: 20250
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Tecr
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Tecr in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Tecr (trans-2,3-enoyl-CoA reductase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: fatty acid biosynthetic process, fatty acid elongation, fatty acid metabolic process, lipid metabolic process, sphingolipid metabolic process, steroid biosynthetic process, very long-chain fatty acid biosynthetic process; MF: oxidoreductase activity, oxidoreductase activity, acting on the CH-CH group of donors, very-long-chain enoyl-CoA reductase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Biosynthesis of unsaturated fatty acids - Mus musculus (mouse), Fatty acid elongation - Mus musculus (mouse), Fatty acid metabolism, Fatty acyl-CoA biosynthesis, Metabolism, Metabolism of lipids, Synthesis of very long-chain fatty acyl-CoAs
UniProt: Q9CY27
Entrez ID: 106529
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Pfn1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Pfn1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Pfn1 (profilin 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin cytoskeleton organization, modification of postsynaptic actin cytoskeleton, modulation of chemical synaptic transmission, negative regulation of actin filament bundle assembly, negative regulation of stress fiber assembly, neural tube closure, positive regulation of DNA metabolic process, positive regulation of actin filament bundle assembly, positive regulation of actin filament polymerization, positive regulation of epithelial cell migration, positive regulation of ruffle assembly, positive regulation of stress fiber assembly, positive regulation of transcription by RNA polymerase II, positive regulation of viral transcription, protein stabilization, regulation of actin filament organization, regulation of actin filament polymerization, regulation of actin polymerization or depolymerization, regulation of transcription by RNA polymerase II, synapse maturation; MF: actin binding, actin monomer binding, actin monomer sequestering activity, adenyl-nucleotide exchange factor activity, phosphatidylinositol-4,5-bisphosphate binding, phosphotyrosine residue binding, proline-rich region binding, protein binding, signaling receptor binding, small GTPase binding; CC: Schaffer collateral - CA1 synapse, cell cortex, cytoplasm, cytoskeleton, cytosol, extracellular region, glutamatergic synapse, nucleus, parallel fiber to Purkinje cell synapse, postsynapse, presynapse
Pathways: Amyotrophic lateral sclerosis - Mus musculus (mouse), Axon guidance, Beta-catenin independent WNT signaling, Developmental Biology, Nervous system development, PCP/CE pathway, RHO GTPase Effectors, RHO GTPases Activate Formins, Rap1 signaling pathway - Mus musculus (mouse), Regulation of actin cytoskeleton - Mus musculus (mouse), Salmonella infection - Mus musculus (mouse), Signal Transduction, Signaling by ROBO receptors, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by WNT
UniProt: P62962
Entrez ID: 18643
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Alg11
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Alg11 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Alg11 (ALG11 alpha-1,2-mannosyltransferase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: dolichol-linked oligosaccharide biosynthetic process, protein N-linked glycosylation; MF: GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity, glycosyltransferase activity, transferase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: N-Glycan biosynthesis - Mus musculus (mouse), Various types of N-glycan biosynthesis - Mus musculus (mouse)
UniProt: Q3TZM9
Entrez ID: 207958
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Cenpu
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Cenpu in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Cenpu (centromere protein U)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chordate embryonic development, chromosome segregation; CC: centriolar satellite, chromosome, chromosome, centromeric region, cytoplasm, inner kinetochore, kinetochore, nucleoplasm, nucleus
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Chromosome Maintenance, Deposition of new CENPA-containing nucleosomes at the centromere, EML4 and NUDC in mitotic spindle formation, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, Nucleosome assembly, RHO GTPase Effectors, RHO GTPases Activate Formins, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q8C4M7
Entrez ID: 71876
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Ermp1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Ermp1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Ermp1 (endoplasmic reticulum metallopeptidase 1)
Type: protein-coding
Summary: Predicted to enable metal ion binding activity and metalloexopeptidase activity. Predicted to be involved in cellular response to oxidative stress; ovarian follicle development; and proteolysis. Predicted to act upstream of or within endoplasmic reticulum unfolded protein response. Predicted to be located in endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; brain; connective tissue; genitourinary system; and sensory organ. Orthologous to human ERMP1 (endoplasmic reticulum metallopeptidase 1). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: cellular response to oxidative stress, endoplasmic reticulum unfolded protein response, ovarian follicle development, proteolysis; MF: hydrolase activity, metal ion binding, metalloexopeptidase activity, metallopeptidase activity, molecular_function, peptidase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways:
UniProt: Q3UVK0
Entrez ID: 226090
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Ncbp1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Ncbp1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Ncbp1 (nuclear cap binding protein subunit 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 7-methylguanosine mRNA capping, RNA catabolic process, RNA metabolic process, RNA splicing, alternative mRNA splicing, via spliceosome, cap-dependent translational initiation, defense response to virus, histone mRNA metabolic process, mRNA 3'-end processing, mRNA export from nucleus, mRNA metabolic process, mRNA processing, mRNA splicing, via spliceosome, mRNA transcription by RNA polymerase II, mRNA transport, miRNA-mediated post-transcriptional gene silencing, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, positive regulation of cell growth, positive regulation of mRNA 3'-end processing, positive regulation of mRNA splicing, via spliceosome, positive regulation of transcription elongation by RNA polymerase II, primary miRNA processing, regulation of mRNA processing, regulation of translation, regulation of translational initiation, regulatory ncRNA-mediated gene silencing, regulatory ncRNA-mediated post-transcriptional gene silencing, snRNA export from nucleus, spliceosomal complex assembly; MF: RNA 7-methylguanosine cap binding, RNA binding, RNA cap binding, mRNA binding, molecular adaptor activity, protein binding; CC: RNA cap binding complex, cytoplasm, cytosol, mitochondrion, nuclear cap binding complex, nucleoplasm, nucleus, ribonucleoprotein complex
Pathways: Amyotrophic lateral sclerosis - Mus musculus (mouse), FGFR2 alternative splicing, Formation of RNA Pol II elongation complex , Formation of the Early Elongation Complex, Gene expression (Transcription), Metabolism of RNA, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), Nuclear RNA decay, Nucleocytoplasmic transport - Mus musculus (mouse), Processing of Capped Intron-Containing Pre-mRNA, Processing of Capped Intronless Pre-mRNA, Processing of Intronless Pre-mRNAs, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, RNA Polymerase II Transcription Termination, RNA polymerase II transcribes snRNA genes, SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs, SLBP independent Processing of Histone Pre-mRNAs, Signal Transduction, Signaling by FGFR, Signaling by FGFR2, Signaling by Receptor Tyrosine Kinases, Spliceosome - Mus musculus (mouse), Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNA derived from an Intron-Containing Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, Transport of the SLBP Dependant Mature mRNA, Transport of the SLBP independent Mature mRNA, mRNA 3'-end processing, mRNA Capping, mRNA Splicing, mRNA Splicing - Major Pathway, mRNA Splicing - Minor Pathway, mRNA surveillance pathway - Mus musculus (mouse)
UniProt: Q3UYV9
Entrez ID: 433702
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Baz1b
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Baz1b in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Baz1b (bromodomain adjacent to zinc finger domain, 1B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, chromatin organization, chromatin remodeling, negative regulation of mitotic chromosome condensation, positive regulation of transcription by RNA polymerase I, positive regulation of transcription by RNA polymerase II, positive regulation of transcription by RNA polymerase III, post-translational protein modification; MF: ATP binding, histone H2AXY142 kinase activity, histone binding, histone kinase activity, kinase activity, metal ion binding, non-membrane spanning protein tyrosine kinase activity, nucleotide binding, protein binding, protein tyrosine kinase activity, transferase activity, zinc ion binding; CC: B-WICH complex, WICH complex, chromatin, condensed chromosome, nuclear replication fork, nucleolus, nucleoplasm, nucleus, pericentric heterochromatin
Pathways: B-WICH complex positively regulates rRNA expression, DNA Double Strand Break Response, DNA Double-Strand Break Repair, DNA Repair, Epigenetic regulation of gene expression, Gene expression (Transcription), Positive epigenetic regulation of rRNA expression, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
UniProt: Q9Z277
Entrez ID: 22385
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Ppil2
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Ppil2 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Ppil2 (peptidylprolyl isomerase (cyclophilin)-like 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, mRNA processing, protein folding, protein localization to plasma membrane, protein polyubiquitination, protein ubiquitination; MF: peptidyl-prolyl cis-trans isomerase activity, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, ubiquitin-ubiquitin ligase activity; CC: catalytic step 2 spliceosome, cytoplasm, nucleoplasm, nucleus, plasma membrane, spliceosomal complex
Pathways: Basigin interactions, Cell surface interactions at the vascular wall, Hemostasis, Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Ubiquitin mediated proteolysis - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q9D787
Entrez ID: 66053
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Rnaseh1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Rnaseh1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Rnaseh1 (ribonuclease H1)
Type: protein-coding
Summary: This gene encodes an endonuclease that specifically degrades the RNA of RNA-DNA hybrids and is necessary for DNA replication and repair. This enzyme is present in both mitochondria and nuclei, which are resulted from translation of a single mRNA with two in-frame initiation start codons. The use of the first start codon produces the mitochondrial isoform and the use of the second start codon produces the nuclear isoform. The production of the mitochondrial isoform is modulated by an upstream open reading frame (uORF) which encodes 7aa in mouse. An alternately spliced transcript variant has been found which is a candidate for nonsense-mediated mRNA decay (NMD). [provided by RefSeq, Nov 2013].
Gene Ontology: BP: DNA replication, removal of RNA primer, mitochondrial DNA replication; MF: RNA-DNA hybrid ribonuclease activity, endonuclease activity, hydrolase activity, identical protein binding, magnesium ion binding, metal ion binding, nuclease activity, nucleic acid binding; CC: cytoplasm, mitochondrion, nucleus
Pathways: DNA replication - Mus musculus (mouse)
UniProt: A0A1Y7VM77, E9QLN8
Entrez ID: 19819
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Ankrd52
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Ankrd52 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Ankrd52 (ankyrin repeat domain 52)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q8BTI7
Entrez ID: 237615
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Polr3h
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Polr3h in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Polr3h (polymerase (RNA) III (DNA directed) polypeptide H)
Type: protein-coding
Summary: Predicted to enable DNA-directed RNA polymerase activity. Predicted to be involved in transcription initiation at RNA polymerase III promoter. Predicted to be located in centrosome and nucleoplasm. Predicted to be part of RNA polymerase III complex. Is expressed in several structures, including alimentary system; limb; nervous system; respiratory system; and sensory organ. Used to study primary ovarian insufficiency. Orthologous to human POLR3H (RNA polymerase III subunit H). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: DNA-templated transcription, DNA-templated transcription initiation, defense response to virus, immune system process, innate immune response, nucleobase-containing compound metabolic process, transcription by RNA polymerase III, transcription initiation at RNA polymerase III promoter; MF: DNA binding, DNA-directed RNA polymerase activity; CC: DNA-directed RNA polymerase complex, RNA polymerase III complex, centrosome, nucleoplasm, nucleus
Pathways: Cytosolic DNA-sensing pathway - Mus musculus (mouse), Gene expression (Transcription), RNA Polymerase III Transcription, RNA Polymerase III Transcription Initiation, RNA Polymerase III Transcription Initiation From Type 1 Promoter, RNA Polymerase III Transcription Initiation From Type 2 Promoter, RNA Polymerase III Transcription Initiation From Type 3 Promoter, RNA polymerase - Mus musculus (mouse)
UniProt: Q9D2C6
Entrez ID: 78929
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Atp1a1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Atp1a1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Atp1a1 (ATPase, Na+/K+ transporting, alpha 1 polypeptide)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to mechanical stimulus, cellular response to steroid hormone stimulus, establishment or maintenance of transmembrane electrochemical gradient, intracellular potassium ion homeostasis, intracellular sodium ion homeostasis, membrane hyperpolarization, membrane repolarization, monoatomic ion transport, negative regulation of glucocorticoid biosynthetic process, negative regulation of heart contraction, osmosensory signaling pathway, positive regulation of heart contraction, positive regulation of striated muscle contraction, potassium ion import across plasma membrane, potassium ion transmembrane transport, potassium ion transport, proton transmembrane transport, regulation of blood pressure, regulation of cardiac muscle cell contraction, regulation of sodium ion transport, regulation of the force of heart contraction, response to glycoside, response to xenobiotic stimulus, sodium ion export across plasma membrane, sodium ion homeostasis, sodium ion transmembrane transport, sodium ion transport, transmembrane transport; MF: ADP binding, ATP binding, ATP hydrolysis activity, P-type potassium transmembrane transporter activity, P-type sodium:potassium-exchanging transporter activity, ankyrin binding, metal ion binding, nucleotide binding, phosphatase activity, phosphatidylinositol 3-kinase binding, potassium ion binding, protein binding, protein domain specific binding, protein heterodimerization activity, protein kinase binding, protein-folding chaperone binding, sodium ion binding, steroid hormone binding, transmembrane transporter binding; CC: Golgi apparatus, T-tubule, apical plasma membrane, axon, basolateral plasma membrane, caveola, cell projection, endoplasmic reticulum, endosome, intercalated disc, lateral plasma membrane, melanosome, membrane, myelin sheath, organelle membrane, plasma membrane, postsynaptic density, protein-containing complex, sarcolemma, sodium:potassium-exchanging ATPase complex, sperm flagellum
Pathways: Adrenergic signaling in cardiomyocytes - Mus musculus (mouse), Aldosterone synthesis and secretion - Mus musculus (mouse), Aldosterone-regulated sodium reabsorption - Mus musculus (mouse), Bile secretion - Mus musculus (mouse), Carbohydrate digestion and absorption - Mus musculus (mouse), Cardiac conduction, Cardiac muscle contraction - Mus musculus (mouse), Endocrine and other factor-regulated calcium reabsorption - Mus musculus (mouse), Gastric acid secretion - Mus musculus (mouse), Insulin secretion - Mus musculus (mouse), Ion channel transport, Ion homeostasis, Ion transport by P-type ATPases, Mineral absorption - Mus musculus (mouse), Muscle contraction, Pancreatic secretion - Mus musculus (mouse), Protein digestion and absorption - Mus musculus (mouse), Proximal tubule bicarbonate reclamation - Mus musculus (mouse), Salivary secretion - Mus musculus (mouse), Thyroid hormone signaling pathway - Mus musculus (mouse), Thyroid hormone synthesis - Mus musculus (mouse), Transport of small molecules, cAMP signaling pathway - Mus musculus (mouse), cGMP-PKG signaling pathway - Mus musculus (mouse)
UniProt: Q8VDN2
Entrez ID: 11928
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Ddx49
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Ddx49 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Ddx49 (DEAD box helicase 49)
Type: protein-coding
Summary: Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and RNA helicase activity. Predicted to be involved in positive regulation of cell growth; rRNA processing; and regulation of rRNA stability. Predicted to be located in nucleolus and nucleoplasm. Predicted to be active in nucleus. Orthologous to human DDX49 (DEAD-box helicase 49). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: positive regulation of cell growth, rRNA processing, regulation of rRNA stability; MF: ATP binding, ATP hydrolysis activity, RNA binding, RNA helicase activity, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding; CC: nucleolus, nucleoplasm, nucleus
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q4FZF3
Entrez ID: 234374
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Ccnt1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Ccnt1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Ccnt1 (cyclin T1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, host-mediated activation of viral transcription, positive regulation of DNA-templated transcription, elongation, positive regulation of transcription by RNA polymerase II, positive regulation of transcription elongation by RNA polymerase II, regulation of transcription by RNA polymerase II, response to xenobiotic stimulus; MF: 7SK snRNA binding, DNA binding, DNA-binding transcription factor binding, RNA polymerase binding, chromatin binding, cyclin-dependent protein serine/threonine kinase activator activity, cyclin-dependent protein serine/threonine kinase regulator activity, molecular condensate scaffold activity, protein binding, protein kinase binding, snRNA binding, transcription cis-regulatory region binding; CC: P-TEFb complex, cyclin/CDK positive transcription elongation factor complex, cytosol, nucleoplasm, nucleus
Pathways: ESR-mediated signaling, Estrogen-dependent gene expression, Formation of RNA Pol II elongation complex , Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, RNA polymerase II transcribes snRNA genes, SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription, Signal Transduction, Signaling by Nuclear Receptors, Signaling by TGF-beta Receptor Complex, Signaling by TGFB family members, TP53 Regulates Transcription of DNA Repair Genes, Transcriptional Regulation by TP53, Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer, Transcriptional misregulation in cancer - Mus musculus (mouse)
UniProt: Q9QWV9
Entrez ID: 12455
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Hnrnpab
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Hnrnpab in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Hnrnpab (heterogeneous nuclear ribonucleoprotein A/B)
Type: protein-coding
Summary: This gene encodes a protein with consensus RNA binding domains present in a number of other RNA binding proteins and a glycine-rich C-terminus. This gene overlaps in a tail-to-tail orientation the gene encoding alanine-glyoxylate aminotransferase 2-like 2. Some of the exons of this gene are interspersed with exons of alanine-glyoxylate aminotransferase 2-like 2. Two alternatively spliced transcript variants that encode distinct proteins have been described for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: chromosomal 5-methylcytosine DNA demethylation pathway, epithelial to mesenchymal transition, mRNA modification, negative regulation of RNA metabolic process, negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of macromolecule biosynthetic process, regulation of cellular localization, regulation of gene expression, regulation of intracellular mRNA localization; MF: DNA binding, RNA binding, nucleic acid binding, protein binding, protein-containing complex binding, sequence-specific double-stranded DNA binding; CC: RNA polymerase II transcription regulator complex, chromatin, cytoplasm, dendrite, glutamatergic synapse, mRNA editing complex, neuronal ribonucleoprotein granule, nucleoplasm, nucleus, postsynapse, presynaptic cytosol, protein-containing complex, ribonucleoprotein complex
Pathways:
UniProt: Q99020
Entrez ID: 15384
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Rps27a
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Rps27a in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Rps27a (ribosomal protein S27A)
Type: protein-coding
Summary: Predicted to enable protein tag activity and ubiquitin protein ligase binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in modification-dependent protein catabolic process; protein ubiquitination; and ribosomal small subunit biogenesis. Located in myelin sheath. Is active in synapse. Orthologous to human RPS27A (ribosomal protein S27a). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cytoplasmic translation, modification-dependent protein catabolic process, protein ubiquitination, ribosomal small subunit biogenesis, translation, translation at postsynapse, translation at presynapse; MF: metal ion binding, protein tag activity, structural constituent of ribosome, ubiquitin protein ligase binding, zinc ion binding; CC: cytoplasm, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, endoplasmic reticulum, myelin sheath, nucleolus, nucleoplasm, nucleus, postsynapse, presynapse, ribonucleoprotein complex, ribosome, small-subunit processome, synapse
Pathways: ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), APC-Cdc20 mediated degradation of Nek2A, APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Cyclin B, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, AUF1 (hnRNP D0) binds and destabilizes mRNA, Activated NOTCH1 Transmits Signal to the Nucleus, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE), Activation of NF-kappaB in B cells, Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Adaptive Immune System, Adherens junctions interactions, Aerobic respiration and respiratory electron transport, Aggrephagy, Alpha-protein kinase 1 signaling pathway, Antigen processing: Ubiquitination & Proteasome degradation, Asparagine N-linked glycosylation, Assembly of the pre-replicative complex, Asymmetric localization of PCP proteins, Autodegradation of Cdh1 by Cdh1:APC/C, Autodegradation of the E3 ubiquitin ligase COP1, Autophagy, Axon guidance, Beta-catenin independent WNT signaling, C-type lectin receptors (CLRs), CDK-mediated phosphorylation and removal of Cdc6, CLEC7A (Dectin-1) signaling, Calnexin/calreticulin cycle, Cap-dependent Translation Initiation, Cargo recognition for clathrin-mediated endocytosis, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell death signalling via NRAGE, NRIF and NADE, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cellular Senescence, Cellular response to chemical stress, Cellular response to hypoxia, Cellular responses to stimuli, Cellular responses to stress, Circadian clock, Class I MHC mediated antigen processing & presentation, Clathrin-mediated endocytosis, Co-inhibition by PD-1, Coronavirus disease - COVID-19 - Mus musculus (mouse), Cyclin A:Cdk2-associated events at S phase entry, Cyclin D associated events in G1, Cyclin E associated events during G1/S transition , Cytokine Signaling in Immune system, Cytosolic sensors of pathogen-associated DNA , DDX58/IFIH1-mediated induction of interferon-alpha/beta, DNA Damage Bypass, DNA Damage Recognition in GG-NER, DNA Double Strand Break Response, DNA Double-Strand Break Repair, DNA Repair, DNA Replication, DNA Replication Pre-Initiation, Deactivation of the beta-catenin transactivating complex, Death Receptor Signaling, Dectin-1 mediated noncanonical NF-kB signaling, Degradation of AXIN, Degradation of CDH1, Degradation of CRY and PER proteins, Degradation of DVL, Degradation of GLI1 by the proteasome, Degradation of beta-catenin by the destruction complex, Deubiquitination, Developmental Biology, Downregulation of ERBB2 signaling, Downregulation of ERBB2:ERBB3 signaling, Downregulation of ERBB4 signaling, Downregulation of SMAD2/3:SMAD4 transcriptional activity, Downregulation of TGF-beta receptor signaling, Downstream TCR signaling, Downstream signaling events of B Cell Receptor (BCR), Dual Incision in GG-NER, Dual incision in TC-NER, E3 ubiquitin ligases ubiquitinate target proteins, EGFR downregulation, ER Quality Control Compartment (ERQC), Endosomal Sorting Complex Required For Transport (ESCRT), Eukaryotic Translation Initiation, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, FCERI mediated NF-kB activation, FLT3 Signaling, Fanconi Anemia Pathway, Fc epsilon receptor (FCERI) signaling, Formation of Incision Complex in GG-NER, Formation of TC-NER Pre-Incision Complex, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, G1 Phase, G1/S DNA Damage Checkpoints, G1/S Transition, G2/M Checkpoints, G2/M Transition, GLI3 is processed to GLI3R by the proteasome, GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2, GSK3B-mediated proteasomal degradation of PD-L1(CD274), GTP hydrolysis and joining of the 60S ribosomal subunit, Gap-filling DNA repair synthesis and ligation in GG-NER, Gap-filling DNA repair synthesis and ligation in TC-NER, Gene expression (Transcription), Generic Transcription Pathway, Global Genome Nucleotide Excision Repair (GG-NER), HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Hedgehog 'off' state, Hedgehog 'on' state, Hedgehog ligand biogenesis, Homology Directed Repair, IKK complex recruitment mediated by RIP1, IRAK1 recruits IKK complex, IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation, IRAK2 mediated activation of TAK1 complex, IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation, Immune System, Inactivation of CSF3 (G-CSF) signaling, Innate Immune System, Interferon Signaling, Interferon alpha/beta signaling, Interleukin-1 family signaling, Interleukin-1 signaling, Interleukin-17 signaling, Interleukin-3, Interleukin-5 and GM-CSF signaling, Intracellular signaling by second messengers, Ion channel transport, Iron uptake and transport, JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1, Josephin domain DUBs, KEAP1-NFE2L2 pathway, Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), L13a-mediated translational silencing of Ceruloplasmin expression, M Phase, MAP kinase activation, MAP3K8 (TPL2)-dependent MAPK1/3 activation, MAPK family signaling cascades, MAPK1/MAPK3 signaling, MAPK6/MAPK4 signaling, Macroautophagy, Major pathway of rRNA processing in the nucleolus and cytosol, Membrane Trafficking, Metabolism, Metabolism of RNA, Metabolism of proteins, Metalloprotease DUBs, Mitophagy, Mitophagy - animal - Mus musculus (mouse), Mitotic Anaphase, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, MyD88 cascade initiated on plasma membrane, MyD88 dependent cascade initiated on endosome, MyD88-independent TLR4 cascade , MyD88:MAL(TIRAP) cascade initiated on plasma membrane, N-glycan trimming in the ER and Calnexin/Calreticulin cycle, NF-kB is activated and signals survival, NIK-->noncanonical NF-kB signaling, NOD1/2 Signaling Pathway, NOTCH3 Activation and Transmission of Signal to the Nucleus, NRIF signals cell death from the nucleus, Neddylation, Negative regulation of FGFR1 signaling, Negative regulation of FGFR2 signaling, Negative regulation of FGFR3 signaling, Negative regulation of FGFR4 signaling, Negative regulation of FLT3, Negative regulation of MAPK pathway, Negative regulation of MET activity, Negative regulators of DDX58/IFIH1 signaling, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), Nuclear events mediated by NFE2L2, Nucleotide Excision Repair, Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, Oncogene Induced Senescence, Orc1 removal from chromatin, Ovarian tumor domain proteases, Oxidative Stress Induced Senescence, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, PCP/CE pathway, PD-L1(CD274) glycosylation and translocation to plasma membrane, PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, PINK1-PRKN Mediated Mitophagy, PIP3 activates AKT signaling, PTEN Regulation, PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1, Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Peroxisomal protein import, Pexophagy, Plasma lipoprotein assembly, remodeling, and clearance, Plasma lipoprotein clearance, Post-translational protein modification, Processing of DNA double-strand break ends, Programmed Cell Death, Protein localization, Protein ubiquitination, Pyruvate metabolism, RAF/MAP kinase cascade, RAS processing, RIPK1-mediated regulated necrosis, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Recognition of DNA damage by PCNA-containing replication complex, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks, Regulated Necrosis, Regulation of APC/C activators between G1/S and early anaphase, Regulation of BACH1 activity, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of FZD by ubiquitination, Regulation of Homotypic Cell-Cell Adhesion, Regulation of NF-kappa B signaling, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of PLK1 Activity at G2/M Transition, Regulation of PTEN localization, Regulation of PTEN stability and activity, Regulation of RAS by GAPs, Regulation of RUNX2 expression and activity, Regulation of RUNX3 expression and activity, Regulation of T cell activation by CD28 family, Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 , Regulation of TNFR1 signaling, Regulation of TP53 Activity, Regulation of TP53 Activity through Methylation, Regulation of TP53 Activity through Phosphorylation, Regulation of TP53 Degradation, Regulation of TP53 Expression and Degradation, Regulation of expression of SLITs and ROBOs, Regulation of innate immune responses to cytosolic DNA, Regulation of mRNA stability by proteins that bind AU-rich elements, Regulation of mitotic cell cycle, Regulation of necroptotic cell death, Regulation of pyruvate metabolism, Regulation of signaling by CBL, Ribosomal scanning and start codon recognition, Ribosome - Mus musculus (mouse), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, S Phase, SCF(Skp2)-mediated degradation of p27/p21, SCF-beta-TrCP mediated degradation of Emi1, SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription, SPOP-mediated proteasomal degradation of PD-L1(CD274), SRP-dependent cotranslational protein targeting to membrane, Selective autophagy, Senescence-Associated Secretory Phenotype (SASP), Separation of Sister Chromatids, Signal Transduction, Signaling by CSF3 (G-CSF), Signaling by EGFR, Signaling by ERBB2, Signaling by ERBB4, Signaling by FGFR, Signaling by FGFR1, Signaling by FGFR2, Signaling by FGFR3, Signaling by FGFR4, Signaling by Hedgehog, Signaling by Interleukins, Signaling by MET, Signaling by NOTCH, Signaling by NOTCH1, Signaling by NOTCH3, Signaling by Non-Receptor Tyrosine Kinases, Signaling by PTK6, Signaling by ROBO receptors, Signaling by Receptor Tyrosine Kinases, Signaling by TGF-beta Receptor Complex, Signaling by TGFB family members, Signaling by WNT, Signaling by the B Cell Receptor (BCR), Spry regulation of FGF signaling, Stabilization of p53, Stimuli-sensing channels, Switching of origins to a post-replicative state, Synthesis of DNA, Synthesis of active ubiquitin: roles of E1 and E2 enzymes, TAK1-dependent IKK and NF-kappa-B activation , TCF dependent signaling in response to WNT, TCR signaling, TGF-beta receptor signaling activates SMADs, TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition), TNF signaling, TNFR1-induced NF-kappa-B signaling pathway, TNFR2 non-canonical NF-kB pathway, TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, TRAF6-mediated induction of TAK1 complex within TLR4 complex, TRIF (TICAM1)-mediated TLR4 signaling , Termination of translesion DNA synthesis, The role of GTSE1 in G2/M progression after G2 checkpoint, Toll Like Receptor 10 (TLR10) Cascade, Toll Like Receptor 2 (TLR2) Cascade, Toll Like Receptor 3 (TLR3) Cascade, Toll Like Receptor 4 (TLR4) Cascade, Toll Like Receptor 5 (TLR5) Cascade, Toll Like Receptor 7/8 (TLR7/8) Cascade, Toll Like Receptor 9 (TLR9) Cascade, Toll Like Receptor TLR1:TLR2 Cascade, Toll Like Receptor TLR6:TLR2 Cascade, Toll-like Receptor Cascades, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Transcriptional Regulation by TP53, Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer, Transcriptional regulation by RUNX1, Transcriptional regulation by RUNX2, Transcriptional regulation by RUNX3, Translation, Translation initiation complex formation, Translesion Synthesis by POLH, Translesion synthesis by POLI, Translesion synthesis by POLK, Translesion synthesis by REV1, Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template, Transport of small molecules, UCH proteinases, Ub-specific processing proteases, Ubiquitin mediated proteolysis - Mus musculus (mouse), Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, Ubiquitin-dependent degradation of Cyclin D, VLDLR internalisation and degradation, Vesicle-mediated transport, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, activated TAK1 mediates p38 MAPK activation, p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint, p53-Independent G1/S DNA Damage Checkpoint, p75 NTR receptor-mediated signalling, p75NTR recruits signalling complexes, p75NTR signals via NF-kB, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62983
Entrez ID: 78294
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Syncrip
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Syncrip in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Syncrip (synaptotagmin binding, cytoplasmic RNA interacting protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CRD-mediated mRNA stabilization, RNA splicing, cellular response to type II interferon, chromosomal 5-methylcytosine DNA demethylation pathway, mRNA modification, mRNA processing, negative regulation of mRNA modification, negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay, negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, negative regulation of translation, positive regulation of cytoplasmic translation, positive regulation of translation; MF: RNA binding, mRNA 3'-UTR binding, mRNA 5'-UTR binding, nucleic acid binding, poly(A) binding; CC: CRD-mediated mRNA stability complex, GAIT complex, catalytic step 2 spliceosome, cytoplasm, cytosol, endoplasmic reticulum, glutamatergic synapse, histone pre-mRNA 3'end processing complex, mCRD-mediated mRNA stability complex, mRNA editing complex, neuronal cell body, nucleoplasm, nucleus, organelle, postsynaptic density, proximal dendrite, ribonucleoprotein complex, spliceosomal complex
Pathways:
UniProt: Q7TMK9
Entrez ID: 56403
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Tufm
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Tufm in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Tufm (Tu translation elongation factor, mitochondrial)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial translational elongation, translation, translational elongation; MF: GTP binding, GTPase activity, hydrolase activity, magnesium ion binding, metal ion binding, nucleotide binding, translation elongation factor activity; CC: mitochondrial inner membrane, mitochondrial nucleoid, mitochondrion, myelin sheath, synapse
Pathways:
UniProt: Q8BFR5
Entrez ID: 233870
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Gnl2
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Gnl2 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Gnl2 (guanine nucleotide binding protein nucleolar 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: GTP binding, nucleotide binding; CC: nucleolus, nucleus
Pathways: Ribosome biogenesis in eukaryotes - Mus musculus (mouse)
UniProt: Q99LH1
Entrez ID: 230737
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Trrap
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Trrap in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Trrap (transformation/transcription domain-associated protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, positive regulation of DNA-templated transcription, positive regulation of biosynthetic process, positive regulation of double-strand break repair via homologous recombination, regulation of DNA repair, regulation of DNA-templated transcription, regulation of RNA splicing, regulation of apoptotic process, regulation of cell cycle, regulation of double-strand break repair, regulation of transcription by RNA polymerase II; MF: chromatin binding, protein binding, transcription coactivator activity, transcription coregulator activity; CC: Golgi apparatus, NuA4 histone acetyltransferase complex, SAGA complex, Swr1 complex, histone acetyltransferase complex, nucleoplasm, nucleosome, nucleus, transcription factor TFTC complex, transcription regulator complex
Pathways: Human T-cell leukemia virus 1 infection - Mus musculus (mouse)
UniProt: A0A1D5RLL4, E9QLK7, E9PWT1, F7CGG2, D3YY11, E9PZA7
Entrez ID: 100683
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Rps19bp1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Rps19bp1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Rps19bp1 (ribosomal protein S19 binding protein 1)
Type: protein-coding
Summary: Predicted to enable enzyme binding activity. Predicted to be involved in ribosomal small subunit biogenesis. Located in nucleolus and nucleoplasm. Is expressed in brain; male reproductive gland or organ; and metanephros. Orthologous to human RPS19BP1 (ribosomal protein S19 binding protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: biological_process, ribosomal small subunit biogenesis; MF: enzyme binding, protein binding; CC: cytosol, nucleolus, nucleoplasm, nucleus, small-subunit processome
Pathways: Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Regulation of HSF1-mediated heat shock response
UniProt: Q8C6B9
Entrez ID: 66538
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Ddx18
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Ddx18 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Ddx18 (DEAD box helicase 18)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to estradiol stimulus, maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); MF: ATP binding, ATP hydrolysis activity, RNA binding, RNA helicase activity, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding; CC: chromosome, nucleolus, nucleus
Pathways:
UniProt: Q8K363
Entrez ID: 66942
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Cuta
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Cuta in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Cuta (cutA divalent cation tolerance homolog)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intracellular protein localization, response to metal ion; MF: copper ion binding, enzyme binding; CC: membrane, mitochondrion
Pathways:
UniProt: Q9CQ89
Entrez ID: 67675
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Hsd17b12
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Hsd17b12 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Hsd17b12 (hydroxysteroid (17-beta) dehydrogenase 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: estrogen biosynthetic process, extracellular matrix organization, fatty acid biosynthetic process, fatty acid elongation, saturated fatty acid, lipid metabolic process, positive regulation of cell-substrate adhesion, steroid biosynthetic process; MF: collagen binding, estradiol 17-beta-dehydrogenase [NAD(P)+] activity, fibronectin binding, heparin binding, oxidoreductase activity, very-long-chain 3-oxoacyl-CoA reductase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, extracellular matrix, fatty acid elongase complex, membrane
Pathways: Androgen biosynthesis, Biosynthesis of unsaturated fatty acids - Mus musculus (mouse), Fatty acid elongation - Mus musculus (mouse), Fatty acid metabolism, Fatty acyl-CoA biosynthesis, Metabolism, Metabolism of lipids, Metabolism of steroid hormones, Metabolism of steroids, Steroid hormone biosynthesis - Mus musculus (mouse), Synthesis of very long-chain fatty acyl-CoAs, biosynthesis of estrogens
UniProt: O70503
Entrez ID: 56348
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Txn2
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Txn2 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Txn2 (thioredoxin 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: peptide-methionine (R)-S-oxide reductase activity, peptide-methionine (S)-S-oxide reductase activity, protein-containing complex binding, protein-disulfide reductase activity; CC: dendrite, mitochondrion, neuronal cell body, nucleolus
Pathways: Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Degradation of cysteine and homocysteine, Detoxification of Reactive Oxygen Species, Fluid shear stress and atherosclerosis - Mus musculus (mouse), Metabolism, Metabolism of amino acids and derivatives, NOD-like receptor signaling pathway - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Salmonella infection - Mus musculus (mouse), Sulfur amino acid metabolism
UniProt: P97493
Entrez ID: 56551
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Dynlrb1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Dynlrb1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Dynlrb1 (dynein light chain roadblock-type 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: microtubule-based movement, visual behavior; MF: dynein intermediate chain binding, identical protein binding, protein binding; CC: centrosome, cytoplasm, cytoplasmic dynein complex, cytoskeleton, dynein complex, microtubule
Pathways: Cilium Assembly, Intraflagellar transport, Organelle biogenesis and maintenance, Salmonella infection - Mus musculus (mouse)
UniProt: P62627
Entrez ID: 67068
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Ciapin1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Ciapin1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Ciapin1 (cytokine induced apoptosis inhibitor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, hemopoiesis, iron-sulfur cluster assembly, negative regulation of apoptotic process; MF: 2 iron, 2 sulfur cluster binding, 4 iron, 4 sulfur cluster binding, electron transfer activity, iron ion binding, iron-sulfur cluster binding, metal ion binding, protein binding; CC: cytoplasm, mitochondrial intermembrane space, mitochondrion, nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: Q8WTY4
Entrez ID: 109006
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Sap18
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Sap18 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Sap18 (Sin3-associated polypeptide 18)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, mRNA processing, negative regulation of DNA-templated transcription, negative regulation of mRNA splicing, via spliceosome, positive regulation of apoptotic process, regulation of DNA-templated transcription, regulation of alternative mRNA splicing, via spliceosome; MF: protein binding, transcription corepressor activity; CC: ASAP complex, cytoplasm, cytosol, exon-exon junction complex, histone deacetylase complex, nuclear body, nuclear speck, nucleoplasm, nucleus, transcription regulator complex
Pathways: Chromatin modifying enzymes, Chromatin organization, HDACs deacetylate histones, Metabolism of RNA, Nucleocytoplasmic transport - Mus musculus (mouse), Processing of Capped Intron-Containing Pre-mRNA, mRNA Splicing, mRNA Splicing - Major Pathway, mRNA surveillance pathway - Mus musculus (mouse)
UniProt: O55128
Entrez ID: 20220
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Nrbp2
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Nrbp2 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Nrbp2 (nuclear receptor binding protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intracellular signal transduction, negative regulation of macroautophagy, negative regulation of neuron apoptotic process, nervous system development, neuron differentiation; MF: ATP binding, protein kinase activity, protein serine/threonine kinase activity; CC: cytoplasm, endomembrane system
Pathways:
UniProt: Q91V36
Entrez ID: 223649
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Nsd1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Nsd1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Nsd1 (nuclear receptor-binding SET-domain protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, chromatin remodeling, gastrulation with mouth forming second, methylation, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, regulation of DNA-templated transcription; MF: RNA polymerase II cis-regulatory region sequence-specific DNA binding, chromatin binding, histone H3K36 dimethyltransferase activity, histone H3K36 methyltransferase activity, histone H4K20 methyltransferase activity, histone methyltransferase activity, metal ion binding, methyltransferase activity, nuclear androgen receptor binding, nuclear estrogen receptor binding, nuclear receptor binding, nuclear retinoic acid receptor binding, nuclear retinoid X receptor binding, nuclear thyroid hormone receptor binding, protein binding, transcription coregulator activity, transcription corepressor activity, transferase activity, zinc ion binding; CC: chromatin, chromosome, histone methyltransferase complex, nucleoplasm, nucleus
Pathways: Lysine degradation - Mus musculus (mouse)
UniProt: E9QAE4, A0A286YDS9, Q3UL03, A0A286YDN7, A0A286YE36
Entrez ID: 18193
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Map2k7
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Map2k7 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Map2k7 (mitogen-activated protein kinase kinase 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: JNK cascade, apoptotic process, cellular response to interleukin-1, cellular response to lipopolysaccharide, cellular response to osmotic stress, positive regulation of DNA-templated transcription, positive regulation of ERK1 and ERK2 cascade, positive regulation of JNK cascade, positive regulation of neuron apoptotic process, positive regulation of telomere maintenance, regulation of motor neuron apoptotic process, regulation of neuron apoptotic process, response to UV, response to heat, response to osmotic stress, response to stress, response to tumor necrosis factor, response to wounding, stress-activated MAPK cascade; MF: ATP binding, JUN kinase kinase activity, MAP kinase activity, MAP kinase kinase activity, enzyme binding, kinase activity, magnesium ion binding, metal ion binding, mitogen-activated protein kinase kinase kinase binding, molecular function activator activity, nucleotide binding, protein binding, protein kinase activity, protein kinase binding, protein phosphatase binding, protein serine kinase activity, protein serine/threonine kinase activity, protein tyrosine kinase activity, transferase activity; CC: cytoplasm, nucleus
Pathways: Alcoholic liver disease - Mus musculus (mouse), Alzheimer disease - Mus musculus (mouse), Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Cytokine Signaling in Immune system, Epstein-Barr virus infection - Mus musculus (mouse), ErbB signaling pathway - Mus musculus (mouse), FCERI mediated MAPK activation, Fc epsilon RI signaling pathway - Mus musculus (mouse), Fc epsilon receptor (FCERI) signaling, Fluid shear stress and atherosclerosis - Mus musculus (mouse), GnRH signaling pathway - Mus musculus (mouse), Hepatitis B - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Immune System, Innate Immune System, Interleukin-17 signaling, JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1, Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), MAP kinase activation, MAPK signaling pathway - Mus musculus (mouse), MyD88 cascade initiated on plasma membrane, MyD88 dependent cascade initiated on endosome, MyD88-independent TLR4 cascade , MyD88:MAL(TIRAP) cascade initiated on plasma membrane, Neurotrophin signaling pathway - Mus musculus (mouse), Osteoclast differentiation - Mus musculus (mouse), Oxidative Stress Induced Senescence, Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Protein processing in endoplasmic reticulum - Mus musculus (mouse), Relaxin signaling pathway - Mus musculus (mouse), Salmonella infection - Mus musculus (mouse), Signaling by Interleukins, T cell receptor signaling pathway - Mus musculus (mouse), TNF signaling pathway - Mus musculus (mouse), TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, TRIF (TICAM1)-mediated TLR4 signaling , Tight junction - Mus musculus (mouse), Toll Like Receptor 10 (TLR10) Cascade, Toll Like Receptor 2 (TLR2) Cascade, Toll Like Receptor 3 (TLR3) Cascade, Toll Like Receptor 4 (TLR4) Cascade, Toll Like Receptor 5 (TLR5) Cascade, Toll Like Receptor 7/8 (TLR7/8) Cascade, Toll Like Receptor 9 (TLR9) Cascade, Toll Like Receptor TLR1:TLR2 Cascade, Toll Like Receptor TLR6:TLR2 Cascade, Toll-like Receptor Cascades, Toll-like receptor signaling pathway - Mus musculus (mouse), Yersinia infection - Mus musculus (mouse)
UniProt: Q8CE90
Entrez ID: 26400
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Dennd6a
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Dennd6a in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Dennd6a (DENN domain containing 6A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of cell-cell adhesion mediated by cadherin; MF: guanyl-nucleotide exchange factor activity; CC: cytoplasm, endosome, recycling endosome
Pathways: Membrane Trafficking, RAB GEFs exchange GTP for GDP on RABs, Rab regulation of trafficking, Vesicle-mediated transport
UniProt: Q8BH65
Entrez ID: 211922
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Pet117
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Pet117 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Pet117 (PET117 homolog)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: mitochondrion
Pathways:
UniProt: P0DJF2
Entrez ID: 100048644
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Sco1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Sco1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Sco1 (SCO1 cytochrome c oxidase assembly protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: copper ion homeostasis, cyclooxygenase pathway, gene expression, homeostasis of number of cells, immune response, intracellular copper ion homeostasis, intracellular iron ion homeostasis, intracellular zinc ion homeostasis, leukocyte differentiation, lipid catabolic process, liver development, mitochondrial cytochrome c oxidase assembly, mitochondrion organization, multicellular organism growth, negative regulation of cellular response to insulin stimulus, negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, negative regulation of proteasomal protein catabolic process, positive regulation of CAMKK-AMPK signaling cascade, post-transcriptional regulation of gene expression, protein localization to plasma membrane, protein secretion, respiratory chain complex IV assembly, spleen development, thymus development; MF: metal ion binding, molecular_function, protein binding; CC: membrane, mitochondrial inner membrane, mitochondrion, myofibril
Pathways: Aerobic respiration and respiratory electron transport, Complex IV assembly, Metabolism, Respiratory electron transport
UniProt: Q5SUC9
Entrez ID: 52892
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Mrps28
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Mrps28 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Mrps28 (mitochondrial ribosomal protein S28)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial translation; CC: mitochondrial inner membrane, mitochondrial small ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Translation
UniProt: Q9CY16
Entrez ID: 66230
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Trit1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Trit1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Trit1 (tRNA isopentenyltransferase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial tRNA modification, tRNA modification, tRNA processing; MF: ATP binding, metal ion binding, nucleotide binding, tRNA dimethylallyltransferase activity, transferase activity, zinc ion binding; CC: cytoplasm, mitochondrion, nucleus
Pathways:
UniProt: Q80UN9
Entrez ID: 66966
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Dlst
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Dlst in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Dlst (dihydrolipoamide S-succinyltransferase)
Type: protein-coding
Summary: Predicted to enable dihydrolipoyllysine-residue succinyltransferase activity; heat shock protein binding activity; and protein-folding chaperone binding activity. Predicted to be involved in 2-oxoglutarate metabolic process; nucleoside phosphate metabolic process; and tricarboxylic acid cycle. Located in mitochondrion and myelin sheath. Part of oxoglutarate dehydrogenase complex. Is expressed in several structures, including alimentary system; metanephros; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in Alzheimer's disease and paraganglioma. Orthologous to human DLST (dihydrolipoamide S-succinyltransferase). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: 2-oxoglutarate decarboxylation to succinyl-CoA, 2-oxoglutarate metabolic process, L-lysine catabolic process to acetyl-CoA via saccharopine, succinyl-CoA metabolic process, tricarboxylic acid cycle; MF: acyltransferase activity, dihydrolipoyllysine-residue succinyltransferase activity, heat shock protein binding, protein binding, protein-folding chaperone binding, transferase activity; CC: cytosol, mitochondrial matrix, mitochondrion, myelin sheath, nucleoplasm, nucleus, oxoadipate dehydrogenase complex, oxoglutarate dehydrogenase complex, sarcolemma
Pathways: 2-ketoglutarate dehydrogenase complex, Aerobic respiration and respiratory electron transport, Citrate cycle (TCA cycle) - Mus musculus (mouse), Citric acid cycle (TCA cycle), Glycine degradation, Glyoxylate metabolism and glycine degradation, Lysine catabolism, Lysine degradation - Mus musculus (mouse), Metabolism, Metabolism of amino acids and derivatives, Metabolism of proteins, OADH complex synthesizes glutaryl-CoA from 2-OA, OGDH complex synthesizes succinyl-CoA from 2-OG, Post-translational protein modification, Protein lipoylation, Tryptophan metabolism - Mus musculus (mouse)
UniProt: Q9D2G2
Entrez ID: 78920
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Sod2
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Sod2 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Sod2 (superoxide dismutase 2, mitochondrial)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure, apoptotic mitochondrial changes, cellular response to ethanol, cellular response to oxidative stress, detection of oxygen, erythrophore differentiation, glutathione metabolic process, heart development, hemopoiesis, hydrogen peroxide biosynthetic process, hydrogen peroxide metabolic process, intracellular oxygen homeostasis, intrinsic apoptotic signaling pathway in response to DNA damage, intrinsic apoptotic signaling pathway in response to oxidative stress, liver development, locomotory behavior, mitochondrion organization, multicellular organismal-level iron ion homeostasis, negative regulation of apoptotic process, negative regulation of cell population proliferation, negative regulation of fat cell differentiation, negative regulation of fibroblast proliferation, negative regulation of membrane hyperpolarization, negative regulation of neuron apoptotic process, negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway, negative regulation of vascular associated smooth muscle cell proliferation, neuron development, positive regulation of cell migration, positive regulation of hydrogen peroxide biosynthetic process, positive regulation of nitric oxide biosynthetic process, positive regulation of vascular associated smooth muscle cell apoptotic process, positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching, post-embryonic development, protein homotetramerization, regulation of blood pressure, regulation of mitochondrial membrane potential, regulation of transcription by RNA polymerase II, release of cytochrome c from mitochondria, removal of superoxide radicals, respiratory electron transport chain, response to L-ascorbic acid, response to activity, response to axon injury, response to cadmium ion, response to electrical stimulus, response to gamma radiation, response to hydrogen peroxide, response to hyperoxia, response to hypoxia, response to immobilization stress, response to isolation stress, response to lipopolysaccharide, response to magnetism, response to manganese ion, response to nutrient levels, response to oxidative stress, response to oxygen levels, response to reactive oxygen species, response to selenium ion, response to silicon dioxide, response to superoxide, response to xenobiotic stimulus, response to zinc ion, superoxide anion generation, superoxide metabolic process, vasodilation; MF: DNA binding, enzyme binding, identical protein binding, manganese ion binding, metal ion binding, oxidoreductase activity, oxygen binding, protein binding, superoxide dismutase activity; CC: cytoplasm, mitochondrial inner membrane, mitochondrial matrix, mitochondrial nucleoid, mitochondrion, myelin sheath
Pathways: Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Detoxification of Reactive Oxygen Species, FoxO signaling pathway - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), Longevity regulating pathway - Mus musculus (mouse), Longevity regulating pathway - multiple species - Mus musculus (mouse), Mitochondrial biogenesis, Organelle biogenesis and maintenance, Peroxisome - Mus musculus (mouse), Transcriptional activation of mitochondrial biogenesis, superoxide radicals degradation
UniProt: P09671
Entrez ID: 20656
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Tra2b
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Tra2b in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Tra2b (transformer 2 beta)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, cellular response to glucose stimulus, cerebral cortex regionalization, embryonic brain development, mRNA processing, mRNA splicing, via spliceosome, positive regulation of mRNA splicing, via spliceosome, regulation of RNA splicing, regulation of alternative mRNA splicing, via spliceosome; MF: RNA binding, identical protein binding, mRNA binding, nucleic acid binding, poly-purine tract binding, pre-mRNA binding, protein binding, protein domain specific binding; CC: male germ cell nucleus, nuclear inner membrane, nucleoplasm, nucleus, perinuclear region of cytoplasm, protein-containing complex, spliceosomal complex
Pathways: Alcoholic liver disease - Mus musculus (mouse), Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, RHO GTPase cycle, RHOBTB GTPase Cycle, RHOBTB1 GTPase cycle, RHOBTB2 GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Spliceosome - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: P62996
Entrez ID: 20462
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Dnajc11
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Dnajc11 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Dnajc11 (DnaJ heat shock protein family (Hsp40) member C11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cristae formation; CC: MICOS complex, SAM complex, membrane, mitochondrial inner membrane, mitochondrial outer membrane, mitochondrion, nuclear speck, nucleoplasm
Pathways:
UniProt: Q5U458
Entrez ID: 230935
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Rpl7
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Rpl7 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Rpl7 (ribosomal protein L7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translation, maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing, ribosomal large subunit biogenesis, translation, translation at postsynapse, translation at presynapse; MF: 5S rRNA binding, DNA binding, RNA binding, identical protein binding, mRNA binding, structural constituent of ribosome; CC: A band, cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, endoplasmic reticulum, nucleolus, postsynapse, postsynaptic density, presynapse, ribonucleoprotein complex, ribosome, synapse
Pathways: Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosome - Mus musculus (mouse), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P14148
Entrez ID: 19989
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Gm4836
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Gm4836 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Gm4836 (predicted gene 4836)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: nucleus
Pathways:
UniProt: Q62478
Entrez ID: 22526
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Leo1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Leo1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Leo1 (Leo1, Paf1/RNA polymerase II complex component)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Wnt signaling pathway, endodermal cell fate commitment, mRNA 3'-end processing, negative regulation of myeloid cell differentiation, positive regulation of transcription by RNA polymerase II, positive regulation of transcription elongation by RNA polymerase II, stem cell population maintenance, transcription elongation by RNA polymerase II; MF: RNA polymerase II C-terminal domain phosphoserine binding, protein binding; CC: Cdc73/Paf1 complex, centrosome, fibrillar center, nucleoplasm, nucleus
Pathways: E3 ubiquitin ligases ubiquitinate target proteins, Formation of RNA Pol II elongation complex , Formation of the beta-catenin:TCF transactivating complex, Gene expression (Transcription), Metabolism of proteins, Post-translational protein modification, Protein ubiquitination, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, Signal Transduction, Signaling by WNT, TCF dependent signaling in response to WNT
UniProt: Q5XJE5
Entrez ID: 235497
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Zfp65
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Zfp65 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Zfp65 (zinc finger protein 65)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in central nervous system; early conceptus; head; and inner cell mass. [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Mus musculus (mouse), RNA Polymerase II Transcription
UniProt: Q8BY64, Q91W94, B8JJX9, A0A286YD24, B8JJY0
Entrez ID: 235907
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Rps14
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Rps14 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Rps14 (ribosomal protein S14)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translation, erythrocyte differentiation, maturation of SSU-rRNA, negative regulation of transcription by RNA polymerase II, ribosomal small subunit assembly, ribosomal small subunit biogenesis, translation, translation at postsynapse, translation at presynapse; MF: RNA binding, mRNA 5'-UTR binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, mitochondrion, nucleolus, nucleus, postsynapse, postsynaptic density, presynapse, ribonucleoprotein complex, ribosome, small-subunit processome, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosomal scanning and start codon recognition, Ribosome - Mus musculus (mouse), Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, Translation initiation complex formation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62264
Entrez ID: 20044
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Fam118a
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Fam118a in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Fam118a (family with sequence similarity 118, member A)
Type: protein-coding
Summary: Predicted to enable identical protein binding activity. Predicted to be located in membrane. Is expressed in cerebral cortex and cerebral cortex marginal layer. Orthologous to human FAM118A (family with sequence similarity 118 member A). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: MF: identical protein binding, molecular_function; CC: cellular_component, membrane
Pathways:
UniProt: Q91YN1
Entrez ID: 73225
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Ap2s1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Ap2s1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Ap2s1 (adaptor-related protein complex 2, sigma 1 subunit)
Type: protein-coding
Summary: Predicted to enable clathrin adaptor activity. Predicted to be involved in postsynaptic neurotransmitter receptor internalization and synaptic vesicle endocytosis. Part of AP-2 adaptor complex. Is active in synapse. Is expressed in 2-cell stage embryo and 4-cell stage embryo. Human ortholog(s) of this gene implicated in familial hypocalciuric hypercalcemia 3. Orthologous to human AP2S1 (adaptor related protein complex 2 subunit sigma 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: clathrin-dependent endocytosis, endocytosis, intracellular protein transport, postsynaptic neurotransmitter receptor internalization, protein transport, synaptic vesicle endocytosis, vesicle-mediated transport; MF: clathrin adaptor activity, protein binding; CC: AP-2 adaptor complex, clathrin-coated pit, cytoplasmic side of plasma membrane, extrinsic component of presynaptic endocytic zone membrane, glutamatergic synapse, intracellular membrane-bounded organelle, membrane, membrane coat, plasma membrane, postsynapse, presynapse, synapse, synaptic vesicle
Pathways: Adaptive Immune System, Axon guidance, Beta-catenin independent WNT signaling, Cargo recognition for clathrin-mediated endocytosis, Clathrin-mediated endocytosis, Developmental Biology, Endocrine and other factor-regulated calcium reabsorption - Mus musculus (mouse), Endocytosis - Mus musculus (mouse), Glutamate binding, activation of AMPA receptors and synaptic plasticity, Huntington disease - Mus musculus (mouse), Immune System, L1CAM interactions, LDL clearance, MHC class II antigen presentation, Membrane Trafficking, Nervous system development, Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, PCP/CE pathway, Plasma lipoprotein assembly, remodeling, and clearance, Plasma lipoprotein clearance, Recycling pathway of L1, Retrograde neurotrophin signalling, Signal Transduction, Signaling by NTRK1 (TRKA), Signaling by NTRKs, Signaling by Receptor Tyrosine Kinases, Signaling by WNT, Synaptic vesicle cycle - Mus musculus (mouse), Trafficking of AMPA receptors, Trafficking of GluR2-containing AMPA receptors, Transmission across Chemical Synapses, Transport of small molecules, VLDLR internalisation and degradation, Vesicle-mediated transport, WNT5A-dependent internalization of FZD2, FZD5 and ROR2, WNT5A-dependent internalization of FZD4
UniProt: P62743
Entrez ID: 232910
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Phb2
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Phb2 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Phb2 (prohibitin 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell activation, RIG-I signaling pathway, antiviral innate immune response, cell migration, mammary gland alveolus development, mammary gland branching involved in thelarche, mitochondrion organization, mitophagy, negative regulation of DNA-templated transcription, negative regulation of apoptotic process, negative regulation of intracellular estrogen receptor signaling pathway, negative regulation of mammary gland epithelial cell proliferation, positive regulation of ERK1 and ERK2 cascade, positive regulation of MAPK cascade, positive regulation of immunoglobulin production, positive regulation of non-canonical NF-kappaB signal transduction, protein import into nucleus, protein stabilization, regulation of branching involved in mammary gland duct morphogenesis, regulation of cardiolipin metabolic process, regulation of cytochrome-c oxidase activity, sister chromatid cohesion; MF: amide binding, identical protein binding, protein binding, protein heterodimerization activity, protein homodimerization activity, sphingolipid binding; CC: GABA-ergic synapse, axon, cell periphery, cell surface, cytoplasm, glutamatergic synapse, inner mitochondrial membrane protein complex, membrane, mitochondrial inner membrane, mitochondrial outer membrane, mitochondrial prohibitin complex, mitochondrion, nuclear matrix, nucleus, plasma membrane, postsynaptic density, presynaptic active zone, protein-containing complex
Pathways: Cellular response to mitochondrial stress, Cellular responses to stimuli, Cellular responses to stress, Mitochondrial calcium ion transport, Processing of SMDT1, Transport of small molecules
UniProt: O35129
Entrez ID: 12034
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Gatb
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Gatb in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Gatb (glutamyl-tRNA amidotransferase subunit B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: glutaminyl-tRNAGln biosynthesis via transamidation, mitochondrial translation, translation; MF: ATP binding, carbon-nitrogen ligase activity, with glutamine as amido-N-donor, catalytic activity, glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity, ligase activity, nucleotide binding; CC: glutamyl-tRNA(Gln) amidotransferase complex, mitochondrion
Pathways: Aminoacyl-tRNA biosynthesis - Mus musculus (mouse)
UniProt: Q99JT1
Entrez ID: 229487
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Uqcc2
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Uqcc2 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Uqcc2 (ubiquinol-cytochrome c reductase complex assembly factor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial respiratory chain complex III assembly, positive regulation of mitochondrial translation, regulation of insulin secretion, regulation of oxidative phosphorylation, regulation of skeletal muscle cell differentiation; CC: membrane, mitochondrial inner membrane, mitochondrial intermembrane space, mitochondrial matrix, mitochondrial nucleoid, mitochondrion, nuclear body
Pathways:
UniProt: Q9CQY6
Entrez ID: 67267
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Ndufs2
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Ndufs2 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Ndufs2 (NADH:ubiquinone oxidoreductase core subunit S2)
Type: protein-coding
Summary: Enables NADH dehydrogenase (ubiquinone) activity and oxygen sensor activity. Involved in several processes, including cellular response to oxygen levels; gliogenesis; and mitochondrial respiratory chain complex I assembly. Located in mitochondrion. Part of respiratory chain complex I. Is active in mitochondrial inner membrane. Is expressed in several structures, including alimentary system; integumental system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in Leigh disease; hypertrophic cardiomyopathy; inherited metabolic disorder; multiple sclerosis; and nuclear type mitochondrial complex I deficiency 6. Orthologous to human NDUFS2 (NADH:ubiquinone oxidoreductase core subunit S2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: aerobic respiration, cellular response to oxygen levels, gliogenesis, mitochondrial ATP synthesis coupled electron transport, mitochondrial electron transport, NADH to ubiquinone, mitochondrial respiratory chain complex I assembly, neural precursor cell proliferation, neurogenesis, proton motive force-driven mitochondrial ATP synthesis, proton transmembrane transport; MF: 4 iron, 4 sulfur cluster binding, NAD binding, NADH dehydrogenase (ubiquinone) activity, NADH dehydrogenase activity, iron-sulfur cluster binding, metal ion binding, oxidoreductase activity, oxidoreductase activity, acting on NAD(P)H, oxygen sensor activity, protein binding, quinone binding, ubiquitin protein ligase binding; CC: membrane, mitochondrial inner membrane, mitochondrion, respiratory chain complex I
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Complex I biogenesis, Diabetic cardiomyopathy - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Metabolism, NADH to cytochrome <i>bd</i> oxidase electron transfer I, NADH to cytochrome <i>bo</i> oxidase electron transfer I, Non-alcoholic fatty liver disease - Mus musculus (mouse), Oxidative phosphorylation - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Respiratory electron transport, Retrograde endocannabinoid signaling - Mus musculus (mouse), Thermogenesis - Mus musculus (mouse), aerobic respiration -- electron donor II
UniProt: Q91WD5
Entrez ID: 226646
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Bend3
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Bend3 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Bend3 (BEN domain containing 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA methylation-dependent constitutive heterochromatin formation, chromatin organization, negative regulation of transcription by RNA polymerase II, positive regulation of ATP metabolic process, protein homooligomerization, rDNA heterochromatin formation; MF: DNA binding, rDNA binding; CC: heterochromatin, nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: Q6PAL0
Entrez ID: 331623
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Ranbp2
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Ranbp2 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Ranbp2 (RAN binding protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: NLS-bearing protein import into nucleus, centrosome localization, cytoplasmic pattern recognition receptor signaling pathway, intracellular glucose homeostasis, mRNA transport, negative regulation of RNA export from nucleus, negative regulation of innate immune response, nuclear export, nucleocytoplasmic transport, protein folding, protein sumoylation, protein transport, regulation of gluconeogenesis, response to amphetamine, toll-like receptor signaling pathway; MF: GTPase activator activity, RNA binding, SUMO ligase activity, SUMO transferase activity, kinase activator activity, metal ion binding, peptidyl-prolyl cis-trans isomerase activity, protein binding, protein-containing complex binding, small GTPase binding, transferase activity, zinc ion binding; CC: SUMO ligase complex, annulate lamellae, cytoplasm, cytoplasmic periphery of the nuclear pore complex, cytosol, membrane, nuclear envelope, nuclear inclusion body, nuclear membrane, nuclear pore, nuclear pore cytoplasmic filaments, nuclear pore nuclear basket, nucleoplasm, nucleus
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Amyotrophic lateral sclerosis - Mus musculus (mouse), Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, EML4 and NUDC in mitotic spindle formation, Gene Silencing by RNA, Gene expression (Transcription), Glucose metabolism, Glycolysis, IP3 and IP4 transport between cytosol and nucleus, IP6 and IP7 transport between cytosol and nucleus, IPs transport between nucleus and cytosol, Inositol phosphate metabolism, M Phase, Metabolism, Metabolism of RNA, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of non-coding RNA, Metabolism of proteins, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Prophase, Mitotic Spindle Checkpoint, Nuclear Envelope Breakdown, Nuclear Pore Complex (NPC) Disassembly, Nucleocytoplasmic transport - Mus musculus (mouse), Post-translational protein modification, Processing of Capped Intron-Containing Pre-mRNA, RHO GTPase Effectors, RHO GTPases Activate Formins, Regulation of Glucokinase by Glucokinase Regulatory Protein, Regulation of HSF1-mediated heat shock response, Resolution of Sister Chromatid Cohesion, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, SUMOylation of DNA replication proteins, SUMOylation of RNA binding proteins, SUMOylation of SUMOylation proteins, SUMOylation of chromatin organization proteins, SUMOylation of ubiquitinylation proteins, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Transcriptional regulation by small RNAs, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNA derived from an Intron-Containing Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, Transport of the SLBP Dependant Mature mRNA, Transport of the SLBP independent Mature mRNA, snRNP Assembly
UniProt: Q9ERU9
Entrez ID: 19386
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Thap1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Thap1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Thap1 (THAP domain containing, apoptosis associated protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA-templated transcription, endothelial cell proliferation, negative regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of mitotic cell cycle, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, identical protein binding, metal ion binding, protein homodimerization activity, sequence-specific DNA binding, zinc ion binding; CC: PML body, fibrillar center, nucleoplasm, nucleus
Pathways:
UniProt: Q8CHW1
Entrez ID: 73754
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Ncbp2
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Ncbp2 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Ncbp2 (nuclear cap binding protein subunit 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, alternative mRNA splicing, via spliceosome, cap-dependent translational initiation, histone mRNA metabolic process, mRNA 3'-end processing, mRNA cis splicing, via spliceosome, mRNA export from nucleus, mRNA metabolic process, mRNA processing, mRNA splicing, via spliceosome, mRNA transcription by RNA polymerase II, mRNA transport, miRNA-mediated post-transcriptional gene silencing, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, positive regulation of RNA export from nucleus, positive regulation of mRNA 3'-end processing, positive regulation of transcription elongation by RNA polymerase II, primary miRNA processing, regulation of translation, regulation of translational initiation, regulatory ncRNA-mediated gene silencing, snRNA export from nucleus; MF: DNA binding, RNA 7-methylguanosine cap binding, RNA binding, RNA cap binding, mRNA binding, nucleic acid binding, snRNA binding; CC: RNA cap binding complex, ciliary basal body, cytoplasm, cytosol, nuclear cap binding complex, nucleoplasm, nucleus
Pathways: FGFR2 alternative splicing, Formation of RNA Pol II elongation complex , Formation of the Early Elongation Complex, Gene expression (Transcription), Metabolism of RNA, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), Nuclear RNA decay, Nucleocytoplasmic transport - Mus musculus (mouse), Processing of Capped Intron-Containing Pre-mRNA, Processing of Capped Intronless Pre-mRNA, Processing of Intronless Pre-mRNAs, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, RNA Polymerase II Transcription Termination, RNA polymerase II transcribes snRNA genes, SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs, SLBP independent Processing of Histone Pre-mRNAs, Signal Transduction, Signaling by FGFR, Signaling by FGFR2, Signaling by Receptor Tyrosine Kinases, Spliceosome - Mus musculus (mouse), Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNA derived from an Intron-Containing Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, Transport of the SLBP Dependant Mature mRNA, Transport of the SLBP independent Mature mRNA, mRNA 3'-end processing, mRNA Capping, mRNA Splicing, mRNA Splicing - Major Pathway, mRNA Splicing - Minor Pathway, mRNA surveillance pathway - Mus musculus (mouse)
UniProt: Q9CQ49
Entrez ID: 68092
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Gins3
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Gins3 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Gins3 (GINS complex subunit 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA replication, cellular senescence, multicellular organism growth; CC: CMG complex, GINS complex, chromosome, nucleoplasm, nucleus
Pathways: Cell Cycle, Cell Cycle, Mitotic, DNA Replication, DNA strand elongation, S Phase, Synthesis of DNA, Unwinding of DNA
UniProt: Q9CY94
Entrez ID: 78833
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Tmem208
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Tmem208 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Tmem208 (transmembrane protein 208)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagy, vacuolar protein processing; CC: endoplasmic reticulum, endoplasmic reticulum membrane, intracellular membrane-bounded organelle, membrane, vacuole
Pathways:
UniProt: Q9CR96
Entrez ID: 66320
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Sox10
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Sox10 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Sox10 (SRY (sex determining region Y)-box 10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, cell maturation, cellular response to progesterone stimulus, cellular response to xenobiotic stimulus, central nervous system myelination, developmental growth, digestive tract morphogenesis, enteric nervous system development, in utero embryonic development, lacrimal gland development, melanocyte differentiation, morphogenesis of a branching epithelium, morphogenesis of an epithelium, negative regulation of DNA-templated transcription, negative regulation of Schwann cell proliferation, negative regulation of apoptotic process, negative regulation of canonical Wnt signaling pathway, negative regulation of transcription by RNA polymerase II, neural crest cell development, neural crest cell migration, oligodendrocyte development, oligodendrocyte differentiation, peripheral nervous system development, positive regulation of DNA-templated transcription, positive regulation of gene expression, positive regulation of gliogenesis, positive regulation of myelination, positive regulation of neuroblast proliferation, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, stem cell differentiation, transcription elongation by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription factor binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, chromatin binding, identical protein binding, promoter-specific chromatin binding, protein binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding; CC: chromatin, cytoplasm, membrane, mitochondrial outer membrane, mitochondrion, nucleoplasm, nucleus
Pathways: Developmental Biology, MITF-M-regulated melanocyte development, Transcriptional and post-translational regulation of MITF-M expression and activity
UniProt: Q04888
Entrez ID: 20665
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Mrps11
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Mrps11 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Mrps11 (mitochondrial ribosomal protein S11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial translation, translation; MF: structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial small ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Ribosome - Mus musculus (mouse)
UniProt: A0A0U1RPK7, Q3U8Y1
Entrez ID: 67994
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Zbtb17
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Zbtb17 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Zbtb17 (zinc finger and BTB domain containing 17)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G1 to G0 transition, ectoderm development, gastrulation with mouth forming second, negative regulation of cell population proliferation, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription factor binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, core promoter sequence-specific DNA binding, metal ion binding, protein binding, transcription coactivator binding, zinc ion binding; CC: nucleus, protein-DNA complex, protein-containing complex
Pathways: Cell cycle - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Small cell lung cancer - Mus musculus (mouse), Transcriptional misregulation in cancer - Mus musculus (mouse)
UniProt: Q60821
Entrez ID: 22642
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Bop1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Bop1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Bop1 (block of proliferation 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell population proliferation, cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), maturation of 5.8S rRNA, maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing, regulation of cell cycle, regulation of signal transduction by p53 class mediator, ribosomal large subunit assembly, ribosomal large subunit biogenesis, ribosome biogenesis; MF: protein binding, ribonucleoprotein complex binding; CC: PeBoW complex, chromosome, nucleolus, nucleoplasm, nucleus, preribosome, large subunit precursor, ribonucleoprotein complex
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P97452
Entrez ID: 12181
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Kras
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Kras in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Kras (Kirsten rat sarcoma viral oncogene homolog)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Ras protein signal transduction, actin cytoskeleton organization, cardiac muscle cell proliferation, cytokine-mediated signaling pathway, epithelial tube branching involved in lung morphogenesis, female pregnancy, forebrain astrocyte development, gene expression, homeostasis of number of cells within a tissue, insulin-like growth factor receptor signaling pathway, liver development, myoblast proliferation, negative regulation of epithelial cell differentiation, negative regulation of neuron apoptotic process, positive regulation of Rac protein signal transduction, positive regulation of cellular senescence, positive regulation of gene expression, positive regulation of glial cell proliferation, regulation of long-term neuronal synaptic plasticity, regulation of synaptic transmission, GABAergic, response to glucocorticoid, response to gravity, response to isolation stress, response to mineralocorticoid, signal transduction, skeletal muscle cell differentiation, striated muscle cell differentiation, type I pneumocyte differentiation, visual learning; MF: G protein activity, GDP binding, GMP binding, GTP binding, GTPase activity, LRR domain binding, hydrolase activity, identical protein binding, nucleotide binding, protein binding, protein-containing complex binding, protein-membrane adaptor activity; CC: cytoplasm, cytoplasmic side of plasma membrane, endomembrane system, membrane, plasma membrane
Pathways: AGE-RAGE signaling pathway in diabetic complications - Mus musculus (mouse), Activation of RAS in B cells, Acute myeloid leukemia - Mus musculus (mouse), Adaptive Immune System, Alcoholism - Mus musculus (mouse), Aldosterone-regulated sodium reabsorption - Mus musculus (mouse), Alzheimer disease - Mus musculus (mouse), Apelin signaling pathway - Mus musculus (mouse), Apoptosis - Mus musculus (mouse), Autophagy - animal - Mus musculus (mouse), Axon guidance, Axon guidance - Mus musculus (mouse), B cell receptor signaling pathway - Mus musculus (mouse), Beta-catenin independent WNT signaling, Bladder cancer - Mus musculus (mouse), Breast cancer - Mus musculus (mouse), C-type lectin receptor signaling pathway - Mus musculus (mouse), C-type lectin receptors (CLRs), CD209 (DC-SIGN) signaling, Ca2+ pathway, Cell surface interactions at the vascular wall, Cellular senescence - Mus musculus (mouse), Central carbon metabolism in cancer - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Chemokine signaling pathway - Mus musculus (mouse), Choline metabolism in cancer - Mus musculus (mouse), Cholinergic synapse - Mus musculus (mouse), Chronic myeloid leukemia - Mus musculus (mouse), Colorectal cancer - Mus musculus (mouse), Cytokine Signaling in Immune system, DAP12 interactions, DAP12 signaling, Developmental Biology, Downstream signal transduction, Downstream signaling events of B Cell Receptor (BCR), Downstream signaling of activated FGFR1, Downstream signaling of activated FGFR2, Downstream signaling of activated FGFR3, Downstream signaling of activated FGFR4, EGFR Transactivation by Gastrin, ESR-mediated signaling, Endometrial cancer - Mus musculus (mouse), ErbB signaling pathway - Mus musculus (mouse), Estrogen signaling pathway - Mus musculus (mouse), Estrogen-stimulated signaling through PRKCZ, Extra-nuclear estrogen signaling, FCERI mediated MAPK activation, FLT3 Signaling, FRS-mediated FGFR1 signaling, FRS-mediated FGFR2 signaling, FRS-mediated FGFR3 signaling, FRS-mediated FGFR4 signaling, Fc epsilon RI signaling pathway - Mus musculus (mouse), Fc epsilon receptor (FCERI) signaling, FoxO signaling pathway - Mus musculus (mouse), G alpha (q) signalling events, GPCR downstream signalling, GRB2 events in EGFR signaling, GRB2 events in ERBB2 signaling, Gap junction - Mus musculus (mouse), Gastric cancer - Mus musculus (mouse), Gastrin-CREB signalling pathway via PKC and MAPK, Glioma - Mus musculus (mouse), GnRH secretion - Mus musculus (mouse), GnRH signaling pathway - Mus musculus (mouse), Growth hormone synthesis, secretion and action - Mus musculus (mouse), Hemostasis, Hepatitis B - Mus musculus (mouse), Hepatitis C - Mus musculus (mouse), Hepatocellular carcinoma - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Immune System, Innate Immune System, Insulin signaling pathway - Mus musculus (mouse), Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), Long-term depression - Mus musculus (mouse), Long-term potentiation - Mus musculus (mouse), Longevity regulating pathway - Mus musculus (mouse), Longevity regulating pathway - multiple species - Mus musculus (mouse), MAP2K and MAPK activation, MAPK family signaling cascades, MAPK signaling pathway - Mus musculus (mouse), MAPK1/MAPK3 signaling, MET activates RAS signaling, Melanogenesis - Mus musculus (mouse), Melanoma - Mus musculus (mouse), MicroRNAs in cancer - Mus musculus (mouse), Mitophagy - animal - Mus musculus (mouse), NCAM signaling for neurite out-growth, Natural killer cell mediated cytotoxicity - Mus musculus (mouse), Negative regulation of MAPK pathway, Nervous system development, Neurotrophin signaling pathway - Mus musculus (mouse), Non-small cell lung cancer - Mus musculus (mouse), Oxytocin signaling pathway - Mus musculus (mouse), PD-L1 expression and PD-1 checkpoint pathway in cancer - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases, Pancreatic cancer - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Phospholipase D signaling pathway - Mus musculus (mouse), Progesterone-mediated oocyte maturation - Mus musculus (mouse), Prolactin signaling pathway - Mus musculus (mouse), Prostate cancer - Mus musculus (mouse), Proteoglycans in cancer - Mus musculus (mouse), RAF activation, RAF/MAP kinase cascade, RAS processing, Rap1 signaling pathway - Mus musculus (mouse), Ras signaling pathway - Mus musculus (mouse), Regulation of RAS by GAPs, Regulation of actin cytoskeleton - Mus musculus (mouse), Relaxin signaling pathway - Mus musculus (mouse), Renal cell carcinoma - Mus musculus (mouse), SHC-mediated cascade:FGFR1, SHC-mediated cascade:FGFR2, SHC-mediated cascade:FGFR3, SHC-mediated cascade:FGFR4, SHC1 events in EGFR signaling, SHC1 events in ERBB4 signaling, Serotonergic synapse - Mus musculus (mouse), Signal Transduction, Signaling by CSF3 (G-CSF), Signaling by EGFR, Signaling by ERBB2, Signaling by ERBB4, Signaling by FGFR, Signaling by FGFR1, Signaling by FGFR2, Signaling by FGFR3, Signaling by FGFR4, Signaling by GPCR, Signaling by MET, Signaling by NTRK1 (TRKA), Signaling by NTRKs, Signaling by Non-Receptor Tyrosine Kinases, Signaling by Nuclear Receptors, Signaling by PDGF, Signaling by PTK6, Signaling by Receptor Tyrosine Kinases, Signaling by SCF-KIT, Signaling by VEGF, Signaling by WNT, Signaling by the B Cell Receptor (BCR), Signaling pathways regulating pluripotency of stem cells - Mus musculus (mouse), Signalling to ERKs, Signalling to RAS, Sphingolipid signaling pathway - Mus musculus (mouse), T cell receptor signaling pathway - Mus musculus (mouse), Thermogenesis - Mus musculus (mouse), Thyroid cancer - Mus musculus (mouse), Thyroid hormone signaling pathway - Mus musculus (mouse), Tie2 Signaling, VEGF signaling pathway - Mus musculus (mouse), VEGFA-VEGFR2 Pathway, VEGFR2 mediated cell proliferation, Viral carcinogenesis - Mus musculus (mouse), mTOR signaling pathway - Mus musculus (mouse), p38MAPK events
UniProt: P32883
Entrez ID: 16653
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Nxf1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Nxf1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Nxf1 (nuclear RNA export factor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA export from nucleus, mRNA export from nucleus, mRNA transport, poly(A)+ mRNA export from nucleus, protein transport; MF: RNA binding, mRNA binding, nucleic acid binding, protein binding; CC: cytoplasm, cytoplasmic stress granule, nuclear RNA export factor complex, nuclear envelope, nuclear inclusion body, nuclear pore, nuclear speck, nucleoplasm, nucleus, transcription export complex
Pathways: Amyotrophic lateral sclerosis - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Influenza A - Mus musculus (mouse), Metabolism of RNA, Nucleocytoplasmic transport - Mus musculus (mouse), Processing of Capped Intron-Containing Pre-mRNA, Ribosome biogenesis in eukaryotes - Mus musculus (mouse), Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNA derived from an Intron-Containing Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, Transport of the SLBP Dependant Mature mRNA, Transport of the SLBP independent Mature mRNA, mRNA surveillance pathway - Mus musculus (mouse)
UniProt: Q99JX7
Entrez ID: 53319
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Rnaseh2c
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Rnaseh2c in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Rnaseh2c (ribonuclease H2, subunit C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA catabolic process, mismatch repair; CC: nucleus, ribonuclease H2 complex
Pathways: DNA replication - Mus musculus (mouse)
UniProt: Q9CQ18
Entrez ID: 68209
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Hspa5
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Hspa5 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Hspa5 (heat shock protein 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ER overload response, ERAD pathway, IRE1-mediated unfolded protein response, PERK-mediated unfolded protein response, cellular response to glucose starvation, cellular response to interleukin-4, cerebellar Purkinje cell layer development, cerebellum structural organization, endoplasmic reticulum unfolded protein response, maintenance of protein localization in endoplasmic reticulum, negative regulation of IRE1-mediated unfolded protein response, negative regulation of PERK-mediated unfolded protein response, negative regulation of apoptotic process, negative regulation of protein-containing complex assembly, negative regulation of transforming growth factor beta receptor signaling pathway, positive regulation of cell migration, positive regulation of embryonic development, positive regulation of neuron projection development, positive regulation of protein ubiquitination, post-translational protein targeting to membrane, translocation, protein folding, protein refolding, proteolysis involved in protein catabolic process, response to endoplasmic reticulum stress, translational initiation; MF: ATP binding, ATP hydrolysis activity, ATP-dependent protein folding chaperone, enzyme binding, heat shock protein binding, hydrolase activity, misfolded protein binding, nucleotide binding, protein binding, protein domain specific binding, protein folding chaperone, protein serine/threonine kinase inhibitor activity, ribosome binding, ubiquitin protein ligase binding, unfolded protein binding; CC: COP9 signalosome, cell surface, cytoplasm, cytosol, dendritic shaft, endoplasmic reticulum, endoplasmic reticulum chaperone complex, endoplasmic reticulum lumen, endoplasmic reticulum membrane, endoplasmic reticulum-Golgi intermediate compartment, extracellular region, melanosome, membrane, midbody, mitochondrion, myelin sheath, neuronal cell body, nucleus, plasma membrane, protein-containing complex, smooth endoplasmic reticulum
Pathways: Adaptive Immune System, Amyotrophic lateral sclerosis - Mus musculus (mouse), Antigen Presentation: Folding, assembly and peptide loading of class I MHC, Antigen processing and presentation - Mus musculus (mouse), Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Class I MHC mediated antigen processing & presentation, Immune System, Lipid and atherosclerosis - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Protein export - Mus musculus (mouse), Protein processing in endoplasmic reticulum - Mus musculus (mouse), Regulation of HSF1-mediated heat shock response, Thyroid hormone synthesis - Mus musculus (mouse)
UniProt: P20029
Entrez ID: 14828
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Prmt1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Prmt1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Prmt1 (protein arginine N-methyltransferase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: BMP signaling pathway, DNA damage response, RNA splicing, TORC1 signaling, cardiac muscle tissue development, cellular response to amino acid starvation, cellular response to methionine, cellular response to nutrient levels, chromatin remodeling, double-strand break repair via homologous recombination, in utero embryonic development, membraneless organelle assembly, methylation, negative regulation of BMP signaling pathway, negative regulation of JNK cascade, negative regulation of TORC1 signaling, negative regulation of double-strand break repair via homologous recombination, negative regulation of megakaryocyte differentiation, negative regulation of translation, negative regulation of translational initiation, neuron projection development, positive regulation of TORC1 signaling, positive regulation of cell population proliferation, positive regulation of double-strand break repair via homologous recombination, positive regulation of erythrocyte differentiation, positive regulation of translation, protein homooligomerization, protein localization to lysosome, regulation of BMP signaling pathway, regulation of DNA-templated transcription, regulation of megakaryocyte differentiation; MF: GATOR1 complex binding, N-methyltransferase activity, S-adenosyl-L-methionine binding, enzyme binding, histone H4R3 methyltransferase activity, histone methyltransferase activity, identical protein binding, methyl-CpG binding, methyltransferase activity, mitogen-activated protein kinase p38 binding, protein binding, protein methyltransferase activity, protein-arginine N-methyltransferase activity, protein-arginine omega-N asymmetric methyltransferase activity, protein-arginine omega-N monomethyltransferase activity, snoRNP binding, transferase activity; CC: cytoplasm, cytosol, lysosomal membrane, lysosome, membrane, methylosome, nucleoplasm, nucleus, protein-containing complex
Pathways: Chromatin modifying enzymes, Chromatin organization, ESR-mediated signaling, Estrogen-dependent gene expression, Extra-nuclear estrogen signaling, FoxO signaling pathway - Mus musculus (mouse), Gene expression (Transcription), Generic Transcription Pathway, Glucagon signaling pathway - Mus musculus (mouse), RMTs methylate histone arginines, RNA Polymerase II Transcription, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function, Signal Transduction, Signaling by Nuclear Receptors, Transcriptional regulation by RUNX1
UniProt: Q9JIF0
Entrez ID: 15469
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Eif4e
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Eif4e in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Eif4e (eukaryotic translation initiation factor 4E)
Type: protein-coding
Summary: This gene encodes a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of messenger RNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the 5'-cap structure. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. This gene acts as a proto-oncogene, and its expression and activation is associated with transformation and tumorigenesis. It has also been associated with autism spectrum disorders. Consistently, knockout of this gene results in increased translation of neuroligins, postsynaptic proteins linked to autism spectrum disorders. Pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: G1/S transition of mitotic cell cycle, behavioral fear response, cellular response to dexamethasone stimulus, mRNA export from nucleus, mRNA transport, negative regulation of neuron differentiation, negative regulation of translation, nuclear export, positive regulation of mitotic cell cycle, regulation of translation, regulation of translation at postsynapse, modulating synaptic transmission, stem cell population maintenance, translation, translational initiation; MF: DNA-binding transcription factor binding, RNA 7-methylguanosine cap binding, RNA binding, enzyme binding, eukaryotic initiation factor 4G binding, mRNA cap binding, protein binding, translation initiation factor activity; CC: P-body, RISC complex, chromatoid body, cytoplasm, cytoplasmic ribonucleoprotein granule, cytoplasmic stress granule, cytosol, eukaryotic translation initiation factor 4F complex, glutamatergic synapse, nuclear body, nuclear speck, nucleus, perinuclear region of cytoplasm, postsynapse, postsynaptic cytosol, protein-containing complex
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Antiviral mechanism by IFN-stimulated genes, Cap-dependent Translation Initiation, Cytokine Signaling in Immune system, Deadenylation of mRNA, Deadenylation-dependent mRNA decay, Eukaryotic Translation Initiation, GTP hydrolysis and joining of the 60S ribosomal subunit, HIF-1 signaling pathway - Mus musculus (mouse), ISG15 antiviral mechanism, Immune System, Insulin signaling pathway - Mus musculus (mouse), Interferon Signaling, L13a-mediated translational silencing of Ceruloplasmin expression, Longevity regulating pathway - Mus musculus (mouse), MTOR signalling, Metabolism of RNA, Metabolism of proteins, PI3K-Akt signaling pathway - Mus musculus (mouse), Processing of Capped Intron-Containing Pre-mRNA, Ribosomal scanning and start codon recognition, Signal Transduction, Translation, Translation initiation complex formation, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, Transport of the SLBP Dependant Mature mRNA, Transport of the SLBP independent Mature mRNA, mTOR signaling pathway - Mus musculus (mouse), mTORC1-mediated signalling
UniProt: P63073
Entrez ID: 13684
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Dnm1l
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Dnm1l in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Dnm1l (dynamin 1-like)
Type: protein-coding
Summary: This gene encodes a member of the dynamin family. The encoded protein is localized to the cytoplasm and mitochondrial membrane, is involved in mitochondrial and peroxisomal division, and is essential for mitochondrial fission. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 2. [provided by RefSeq, Feb 2013].
Gene Ontology: BP: calcium ion transport, cellular response to hypoxia, cellular response to lipid, endocytosis, heart contraction, intracellular distribution of mitochondria, metal ion transport, mitochondrial fission, mitochondrial fragmentation involved in apoptotic process, mitochondrial membrane fission, mitochondrion distribution, mitochondrion organization, mitocytosis, negative regulation of mitochondrial fusion, peroxisome fission, positive regulation of dendritic spine morphogenesis, positive regulation of mitochondrial fission, positive regulation of neutrophil chemotaxis, positive regulation of protein secretion, positive regulation of synaptic vesicle endocytosis, positive regulation of synaptic vesicle exocytosis, programmed cell death, protein complex oligomerization, protein localization to mitochondrion, regulation of ATP metabolic process, regulation of gene expression, regulation of mitochondrion organization, regulation of mitophagy, regulation of peroxisome organization, response to endoplasmic reticulum stress, response to flavonoid, response to hypobaric hypoxia, rhythmic process, synaptic vesicle endocytosis, synaptic vesicle recycling via endosome; MF: BH2 domain binding, GTP binding, GTP-dependent protein binding, GTPase activity, clathrin binding, hydrolase activity, identical protein binding, lipid binding, microtubule binding, nucleotide binding, protein binding, protein homodimerization activity, protein serine/threonine kinase binding, protein-containing complex binding, small GTPase binding, ubiquitin protein ligase binding; CC: Golgi apparatus, Golgi membrane, brush border, clathrin-coated pit, cytoplasm, cytoplasmic vesicle, cytosol, endomembrane system, endoplasmic reticulum, endosome, late endosome, lysosome, membrane, microtubule, microtubule cytoskeleton, mitochondrial membrane, mitochondrial outer membrane, mitochondrion, mitochondrion-derived vesicle, perinuclear region of cytoplasm, peroxisome, plasma membrane, postsynaptic density, presynaptic endocytic zone membrane, protein-containing complex, secretory vesicle, synapse, synaptic vesicle membrane
Pathways: NOD-like receptor signaling pathway - Mus musculus (mouse), Necroptosis - Mus musculus (mouse), TNF signaling pathway - Mus musculus (mouse)
UniProt: Q8K1M6
Entrez ID: 74006
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Dusp12
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Dusp12 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Dusp12 (dual specificity phosphatase 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: hydrolase activity, kinase binding, metal ion binding, phosphatase activity, phosphoprotein phosphatase activity, protein serine/threonine phosphatase activity, protein tyrosine phosphatase activity, protein tyrosine/serine/threonine phosphatase activity, zinc ion binding; CC: cytoplasm, cytosol, nucleoplasm, nucleus
Pathways:
UniProt: Q9D0T2
Entrez ID: 80915
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Rev1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Rev1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Rev1 (REV1, DNA directed polymerase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA biosynthetic process, DNA damage response, DNA metabolic process, DNA repair, error-free translesion synthesis, error-prone translesion synthesis, response to UV, somatic hypermutation of immunoglobulin genes, translesion synthesis; MF: DNA binding, DNA-directed DNA polymerase activity, damaged DNA binding, deoxycytidyl transferase activity, metal ion binding, nucleotidyltransferase activity, protein binding, protein-macromolecule adaptor activity, transferase activity, ubiquitin binding; CC: nuclear replication fork, nucleus, site of DNA damage
Pathways: DNA Damage Bypass, DNA Repair, Fanconi anemia pathway - Mus musculus (mouse), Termination of translesion DNA synthesis, Translesion synthesis by POLI, Translesion synthesis by POLK, Translesion synthesis by REV1, Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
UniProt: Q920Q2
Entrez ID: 56210
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Vps16
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Vps16 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Vps16 (VSP16 CORVET/HOPS core subunit)
Type: protein-coding
Summary: Enables actin binding activity. Acts upstream of or within symbiont entry into host cell. Located in actin filament; clathrin-coated vesicle; and early endosome membrane. Part of AP-3 adaptor complex and CORVET complex. Used to study dystonia. Human ortholog(s) of this gene implicated in dystonia 30. Orthologous to human VPS16 (VPS16 core subunit of CORVET and HOPS complexes). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: autophagosome maturation, autophagy, endosomal transport, endosome to lysosome transport, intracellular protein transport, protein transport, symbiont entry into host cell, vacuole fusion, non-autophagic, vacuole organization; MF: actin binding, actin filament binding, protein binding; CC: AP-3 adaptor complex, CORVET complex, HOPS complex, actin filament, autophagosome, axon, clathrin-coated vesicle, cytoplasm, cytoplasmic vesicle, early endosome, early endosome membrane, endosome, endosome membrane, late endosome, late endosome membrane, lysosomal membrane, lysosome, membrane, neuronal cell body, presynapse, recycling endosome, vesicle tethering complex
Pathways: Salmonella infection - Mus musculus (mouse)
UniProt: G3X8X7, Q8BWV2, Q8C016, A2BI90
Entrez ID: 80743
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Srsf11
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Srsf11 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Srsf11 (serine and arginine-rich splicing factor 11)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014].
Gene Ontology: BP: RNA splicing, biological_process; MF: RNA binding, identical protein binding, molecular_function, nucleic acid binding; CC: nuclear speck, nucleoplasm
Pathways: Gene expression (Transcription), Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA derived from an Intron-Containing Transcript, mRNA 3'-end processing, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q8BV04, Q3UIX4, E9Q6E5, F6TN80, A0A0G2JEG1, D3Z4B0, F6X2U6, F6RDI8, D6RE22
Entrez ID: 69207
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Fbl
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Fbl in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Fbl (fibrillarin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: box C/D sno(s)RNA 3'-end processing, chromatin remodeling, methylation, rRNA methylation, rRNA processing, ribosomal small subunit biogenesis, sno(s)RNA metabolic process, snoRNA localization; MF: ATPase binding, RNA binding, TFIID-class transcription factor complex binding, U6 snRNA 2'-O-ribose methyltransferase activity, histone H2AQ104 methyltransferase activity, methyltransferase activity, rRNA methyltransferase activity, transferase activity; CC: Cajal body, box C/D methylation guide snoRNP complex, chromosome, dense fibrillar component, fibrillar center, granular component, nucleolus, nucleoplasm, nucleus, ribonucleoprotein complex, small-subunit processome
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Ribosome biogenesis in eukaryotes - Mus musculus (mouse), rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P35550
Entrez ID: 14113
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Stoml2
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Stoml2 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Stoml2 (stomatin (Epb7.2)-like 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CD4-positive, alpha-beta T cell activation, T cell receptor signaling pathway, intracellular calcium ion homeostasis, lipid localization, mitochondrial protein processing, mitochondrion localization, mitochondrion organization, positive regulation of interleukin-2 production, protein complex oligomerization, proton motive force-driven mitochondrial ATP synthesis, stress-induced mitochondrial fusion; MF: GTPase binding, T cell receptor binding, cardiolipin binding, lipid binding; CC: actin cytoskeleton, cytoplasm, cytoskeleton, immunological synapse, membrane, membrane raft, mitochondrial inner membrane, mitochondrial intermembrane space, mitochondrion, plasma membrane
Pathways: Cellular response to mitochondrial stress, Cellular responses to stimuli, Cellular responses to stress, Mitochondrial calcium ion transport, Processing of SMDT1, Transport of small molecules
UniProt: Q99JB2
Entrez ID: 66592
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Mrpl16
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Mrpl16 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Mrpl16 (mitochondrial ribosomal protein L16)
Type: protein-coding
Summary: Predicted to enable rRNA binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Predicted to act upstream of or within translation. Located in mitochondrion. Is expressed in several structures, including early conceptus; gonad; heart; liver; and metanephros. Orthologous to human MRPL16 (mitochondrial ribosomal protein L16). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: mitochondrial translation, translation; MF: rRNA binding, structural constituent of ribosome; CC: large ribosomal subunit, mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Ribosome - Mus musculus (mouse), Translation
UniProt: Q99N93
Entrez ID: 94063
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Atp6v0c
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Atp6v0c in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Atp6v0c (ATPase, H+ transporting, lysosomal V0 subunit C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: lysosomal lumen acidification, monoatomic ion transport, negative regulation of autophagic cell death, positive regulation of ERK1 and ERK2 cascade, positive regulation of Wnt signaling pathway, proton transmembrane transport, synaptic vesicle lumen acidification, vacuolar acidification; MF: P-type proton-exporting transporter activity, protein binding, proton transmembrane transporter activity, proton-transporting ATPase activity, rotational mechanism, ubiquitin protein ligase binding; CC: bounding membrane of organelle, clathrin-coated vesicle membrane, cytoplasmic vesicle, membrane, proton-transporting V-type ATPase complex, proton-transporting V-type ATPase, V0 domain, proton-transporting two-sector ATPase complex, proton-transporting domain, synapse, synaptic vesicle, synaptic vesicle membrane, vacuolar proton-transporting V-type ATPase complex, vacuolar proton-transporting V-type ATPase, V0 domain
Pathways: Amino acids regulate mTORC1, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Collecting duct acid secretion - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Immune System, Innate Immune System, Insulin receptor recycling, Ion channel transport, Iron uptake and transport, Lysosome - Mus musculus (mouse), Neutrophil degranulation, Oxidative phosphorylation - Mus musculus (mouse), Phagosome - Mus musculus (mouse), ROS and RNS production in phagocytes, Rheumatoid arthritis - Mus musculus (mouse), Signal Transduction, Signaling by Insulin receptor, Signaling by Receptor Tyrosine Kinases, Synaptic vesicle cycle - Mus musculus (mouse), Transferrin endocytosis and recycling, Transport of small molecules, Tuberculosis - Mus musculus (mouse)
UniProt: P63082
Entrez ID: 11984
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Mrpl33
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Mrpl33 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Mrpl33 (mitochondrial ribosomal protein L33)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial translation, translation; CC: cytosol, mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Ribosome - Mus musculus (mouse), Translation
UniProt: Q9CQP0
Entrez ID: 66845
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Mad2l1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Mad2l1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Mad2l1 (MAD2 mitotic arrest deficient-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, establishment of centrosome localization, establishment of mitotic spindle orientation, mitotic sister chromatid segregation, mitotic spindle assembly checkpoint signaling, negative regulation of mitotic cell cycle, negative regulation of mitotic cell cycle phase transition, negative regulation of mitotic metaphase/anaphase transition, negative regulation of protein catabolic process, positive regulation of mitotic cell cycle spindle assembly checkpoint, regulation of nuclear division; MF: identical protein binding, protein binding, protein homodimerization activity; CC: chromosome, chromosome, centromeric region, cytoplasm, cytoskeleton, cytosol, kinetochore, mitotic checkpoint complex, mitotic spindle, mitotic spindle assembly checkpoint MAD1-MAD2 complex, nuclear pore nuclear basket, nucleoplasm, nucleus, perinuclear region of cytoplasm, spindle pole
Pathways: APC-Cdc20 mediated degradation of Nek2A, APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of mitotic proteins, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle - Mus musculus (mouse), EML4 and NUDC in mitotic spindle formation, Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Inactivation of APC/C via direct inhibition of the APC/C complex, Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, Oocyte meiosis - Mus musculus (mouse), Progesterone-mediated oocyte maturation - Mus musculus (mouse), RHO GTPase Effectors, RHO GTPases Activate Formins, Regulation of APC/C activators between G1/S and early anaphase, Regulation of mitotic cell cycle, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q9Z1B5
Entrez ID: 56150
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Acat2
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Acat2 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Acat2 (acetyl-Coenzyme A acetyltransferase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cholesterol biosynthetic process via desmosterol, cholesterol biosynthetic process via lathosterol, fatty acid metabolic process, isopentenyl diphosphate biosynthetic process, mevalonate pathway, zymosterol biosynthetic process; MF: acetyl-CoA C-acetyltransferase activity, acyltransferase activity, acyltransferase activity, transferring groups other than amino-acyl groups, transferase activity; CC: cytoplasm, cytosol, mitochondrion
Pathways: 2-methylbutyrate biosynthesis, Butanoate metabolism - Mus musculus (mouse), Cholesterol biosynthesis, Fat digestion and absorption - Mus musculus (mouse), Fatty acid degradation - Mus musculus (mouse), Glyoxylate and dicarboxylate metabolism - Mus musculus (mouse), Lysine degradation - Mus musculus (mouse), Metabolism, Metabolism of lipids, Metabolism of steroids, Pyruvate metabolism - Mus musculus (mouse), Terpenoid backbone biosynthesis - Mus musculus (mouse), Tryptophan metabolism - Mus musculus (mouse), Valine, leucine and isoleucine degradation - Mus musculus (mouse), acetoacetate degradation (to acetyl CoA), glutaryl-CoA degradation, isoleucine degradation, ketogenesis, ketolysis, ketone oxidation, mevalonate pathway I, superpathway of cholesterol biosynthesis, tryptophan degradation III (eukaryotic)
UniProt: Q8CAY6
Entrez ID: 110460
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Gm9758
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Gm9758 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Gm9758 (predicted gene 9758)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q80ZT2
Entrez ID: 381714
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Rpl30
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Rpl30 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Rpl30 (ribosomal protein L30)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: antimicrobial humoral immune response mediated by antimicrobial peptide, cytoplasmic translation, defense response to Gram-negative bacterium, killing of cells of another organism; MF: RNA binding, selenocysteine insertion sequence binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, nucleus, postsynapse, postsynaptic density, ribonucleoprotein complex, ribosome, synapse
Pathways: Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosome - Mus musculus (mouse), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62889
Entrez ID: 19946
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Rbm41
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Rbm41 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Rbm41 (RNA binding motif protein 41)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: RNA binding, U12 snRNA binding, nucleic acid binding, pre-mRNA intronic binding
Pathways:
UniProt: Q8JZV4
Entrez ID: 237073
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Cstf2
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Cstf2 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Cstf2 (cleavage stimulation factor, 3' pre-RNA subunit 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to nerve growth factor stimulus, mRNA 3'-end processing, mRNA processing; MF: RNA binding, mRNA binding, nucleic acid binding; CC: cleavage body, mRNA cleavage and polyadenylation specificity factor complex, nuclear body, nucleoplasm, nucleus
Pathways: Gene expression (Transcription), Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Processing of Capped Intronless Pre-mRNA, Processing of Intronless Pre-mRNAs, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, mRNA 3'-end processing, mRNA surveillance pathway - Mus musculus (mouse)
UniProt: Q8BIQ5
Entrez ID: 108062
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Vmn2r36
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Vmn2r36 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Vmn2r36 (vomeronasal 2, receptor 36)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, signal transduction; MF: G protein-coupled receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: K7N741
Entrez ID: 100042653
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Fh1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Fh1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Fh1 (fumarate hydratase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, arginine metabolic process, fumarate metabolic process, homeostasis of number of cells within a tissue, malate metabolic process, positive regulation of cold-induced thermogenesis, positive regulation of double-strand break repair via nonhomologous end joining, regulation of arginine metabolic process, tricarboxylic acid cycle, urea cycle; MF: catalytic activity, fumarate hydratase activity, histone binding, lyase activity; CC: chromosome, cytoplasm, cytosol, mitochondrial matrix, mitochondrion, nucleus, site of double-strand break
Pathways: Aerobic respiration and respiratory electron transport, Citrate cycle (TCA cycle) - Mus musculus (mouse), Citric acid cycle (TCA cycle), Cushing syndrome - Mus musculus (mouse), Metabolism, Metabolism of proteins, Mitochondrial protein degradation, Pathways in cancer - Mus musculus (mouse), Pyruvate metabolism - Mus musculus (mouse), Renal cell carcinoma - Mus musculus (mouse), TCA cycle, TCA cycle variation III (eukaryotic), glutamate degradation VII
UniProt: P97807
Entrez ID: 14194
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Smc6
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Smc6 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Smc6 (structural maintenance of chromosomes 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, cellular senescence, double-strand break repair, double-strand break repair via homologous recombination, host-mediated suppression of viral genome replication, positive regulation of chromosome segregation, telomere maintenance via recombination; MF: ATP binding, ATP hydrolysis activity, DNA secondary structure binding, damaged DNA binding, nucleotide binding, single-stranded DNA binding, ubiquitin protein ligase binding; CC: PML body, Smc5-Smc6 complex, chromosomal region, chromosome, chromosome, centromeric region, chromosome, telomeric region, interchromatin granule, mitotic spindle pole, nuclear speck, nucleoplasm, nucleus, sex chromosome, site of double-strand break
Pathways: Metabolism of proteins, Post-translational protein modification, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins
UniProt: Q924W5
Entrez ID: 67241
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Ndufb8
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Ndufb8 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Ndufb8 (NADH:ubiquinone oxidoreductase subunit B8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: aerobic respiration, mitochondrial electron transport, NADH to ubiquinone, proton motive force-driven mitochondrial ATP synthesis; CC: membrane, mitochondrial inner membrane, mitochondrion, respiratory chain complex I
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Complex I biogenesis, Diabetic cardiomyopathy - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Metabolism, Mitochondrial protein import, NADH to cytochrome <i>bd</i> oxidase electron transfer I, NADH to cytochrome <i>bo</i> oxidase electron transfer I, Non-alcoholic fatty liver disease - Mus musculus (mouse), Oxidative phosphorylation - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Protein localization, Respiratory electron transport, Retrograde endocannabinoid signaling - Mus musculus (mouse), Thermogenesis - Mus musculus (mouse), aerobic respiration -- electron donor II
UniProt: Q9D6J5
Entrez ID: 67264
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Shf
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Shf in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Shf (Src homology 2 domain containing F)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, signal transduction
Pathways:
UniProt: Q8CG80
Entrez ID: 435684
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Kat8
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Kat8 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Kat8 (K(lysine) acetyltransferase 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, dosage compensation by inactivation of X chromosome, epigenetic regulation of gene expression, epithelial to mesenchymal transition, germ cell development, hemopoiesis, membraneless organelle assembly, myeloid cell differentiation, negative regulation of DNA-templated transcription, negative regulation of epithelial to mesenchymal transition, negative regulation of macromolecule biosynthetic process, negative regulation of multicellular organismal process, negative regulation of type I interferon production, neurogenesis, oogenesis, positive regulation of DNA-templated transcription, positive regulation of epithelial to mesenchymal transition, positive regulation of skeletal muscle satellite cell differentiation, positive regulation of transcription initiation by RNA polymerase II, positive regulation of type I interferon production, post-embryonic hemopoiesis, regulation of DNA-templated transcription, regulation of autophagy, regulation of cell differentiation, regulation of mRNA processing, regulation of mitochondrial transcription, transcription initiation-coupled chromatin remodeling; MF: RNA polymerase II-specific DNA-binding transcription factor binding, acetyltransferase activity, acyltransferase activity, chromatin binding, enzyme binding, histone H4 acetyltransferase activity, histone H4K16 acetyltransferase activity, histone H4K5 acetyltransferase activity, histone H4K8 acetyltransferase activity, histone acetyltransferase activity, metal ion binding, promoter-specific chromatin binding, protein binding, protein propionyltransferase activity, protein-lysine-acetyltransferase activity, transcription coactivator activity, transferase activity, zinc ion binding; CC: MLL1 complex, MSL complex, NSL complex, NuA4 histone acetyltransferase complex, chromosome, histone acetyltransferase complex, kinetochore, mitochondrion, nuclear lumen, nuclear matrix, nucleoplasm, nucleus
Pathways: Chromatin modifying enzymes, Chromatin organization, Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of gene expression, Formation of WDR5-containing histone-modifying complexes, Gene expression (Transcription), HATs acetylate histones
UniProt: Q9D1P2
Entrez ID: 67773
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Polr3f
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Polr3f in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Polr3f (polymerase (RNA) III (DNA directed) polypeptide F)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: defense response to virus, immune system process, innate immune response, positive regulation of innate immune response, positive regulation of interferon-beta production, transcription by RNA polymerase III; MF: 4 iron, 4 sulfur cluster binding, double-stranded DNA binding, iron-sulfur cluster binding, metal ion binding; CC: DNA-directed RNA polymerase complex, RNA polymerase III complex, cytoplasm, nucleoplasm, nucleus
Pathways: Cytosolic DNA-sensing pathway - Mus musculus (mouse), Gene expression (Transcription), RNA Polymerase III Transcription, RNA Polymerase III Transcription Initiation, RNA Polymerase III Transcription Initiation From Type 1 Promoter, RNA Polymerase III Transcription Initiation From Type 2 Promoter, RNA Polymerase III Transcription Initiation From Type 3 Promoter, RNA polymerase - Mus musculus (mouse)
UniProt: Q921X6
Entrez ID: 70408
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Ppan
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Ppan in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Ppan (peter pan homolog)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing, regulation of cell growth by extracellular stimulus; MF: rRNA binding; CC: nucleolus, nucleus, preribosome, large subunit precursor
Pathways:
UniProt: Q91YU8
Entrez ID: 235036
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Alyref
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Alyref in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Alyref (Aly/REF export factor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA export from nucleus, RNA folding, RNA splicing, mRNA export from nucleus, mRNA processing, mRNA transport; MF: C5-methylcytidine-containing RNA reader activity, RNA binding, RNA folding chaperone, mRNA binding, molecular adaptor activity, nucleic acid binding, single-stranded DNA binding; CC: catalytic step 2 spliceosome, chromosome, telomeric region, cytoplasm, exon-exon junction complex, nuclear speck, nucleus, spliceosomal complex, transcription export complex
Pathways: Amyotrophic lateral sclerosis - Mus musculus (mouse), Gene expression (Transcription), Herpes simplex virus 1 infection - Mus musculus (mouse), Metabolism of RNA, Nucleocytoplasmic transport - Mus musculus (mouse), Processing of Capped Intron-Containing Pre-mRNA, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, Spliceosome - Mus musculus (mouse), Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNA derived from an Intron-Containing Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, Transport of the SLBP Dependant Mature mRNA, Transport of the SLBP independent Mature mRNA, mRNA 3'-end processing, mRNA Splicing, mRNA Splicing - Major Pathway, mRNA surveillance pathway - Mus musculus (mouse)
UniProt: O08583
Entrez ID: 21681
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Nup62
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Nup62 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Nup62 (nucleoporin 62)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA export from nucleus, cell migration, cell surface receptor signaling pathway, cellular senescence, centriole assembly, centrosome cycle, mRNA transport, mitotic centrosome separation, mitotic metaphase chromosome alignment, negative regulation of MAP kinase activity, negative regulation of Ras protein signal transduction, negative regulation of apoptotic process, negative regulation of cell population proliferation, negative regulation of epidermal growth factor receptor signaling pathway, negative regulation of programmed cell death, nucleocytoplasmic transport, positive regulation of DNA-templated transcription, positive regulation of canonical NF-kappaB signal transduction, positive regulation of centriole replication, positive regulation of mitotic cytokinetic process, positive regulation of mitotic nuclear division, positive regulation of protein localization to centrosome, protein import into nucleus, protein transport, regulation of mitotic spindle organization, regulation of protein import into nucleus; MF: Hsp70 protein binding, Hsp90 protein binding, PTB domain binding, SH2 domain binding, kinesin binding, nuclear thyroid hormone receptor binding, phospholipid binding, protein binding, protein-containing complex binding, signaling receptor complex adaptor activity, structural constituent of nuclear pore, ubiquitin binding; CC: Flemming body, annulate lamellae, centrosome, cytoplasm, cytoskeleton, mitotic spindle, nuclear envelope, nuclear membrane, nuclear pore, nuclear pore central transport channel, nucleoplasm, nucleus, protein-containing complex, ribonucleoprotein complex, spindle pole
Pathways: Amyotrophic lateral sclerosis - Mus musculus (mouse), Cell Cycle, Cell Cycle, Mitotic, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Gene Silencing by RNA, Gene expression (Transcription), Glucose metabolism, Glycolysis, IP3 and IP4 transport between cytosol and nucleus, IP6 and IP7 transport between cytosol and nucleus, IPs transport between nucleus and cytosol, Inositol phosphate metabolism, M Phase, Metabolism, Metabolism of RNA, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of non-coding RNA, Metabolism of proteins, Mitotic Prophase, Nuclear Envelope Breakdown, Nuclear Pore Complex (NPC) Disassembly, Nucleocytoplasmic transport - Mus musculus (mouse), Post-translational protein modification, Processing of Capped Intron-Containing Pre-mRNA, Regulation of Glucokinase by Glucokinase Regulatory Protein, Regulation of HSF1-mediated heat shock response, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, SUMOylation of DNA replication proteins, SUMOylation of RNA binding proteins, SUMOylation of SUMOylation proteins, SUMOylation of chromatin organization proteins, SUMOylation of ubiquitinylation proteins, Transcriptional regulation by small RNAs, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNA derived from an Intron-Containing Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, Transport of the SLBP Dependant Mature mRNA, Transport of the SLBP independent Mature mRNA, snRNP Assembly
UniProt: Q63850
Entrez ID: 18226
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Mrpl52
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Mrpl52 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Mrpl52 (mitochondrial ribosomal protein L52)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial translation, translation; MF: structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, nucleoplasm, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Translation
UniProt: Q9D0Y8
Entrez ID: 68836
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Wdr82
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Wdr82 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Wdr82 (WD repeat domain containing 82)
Type: protein-coding
Summary: Enables chromatin binding activity and lncRNA binding activity. Involved in RNA catabolic process and negative regulation of DNA-templated transcription. Acts upstream of or within gene expression. Located in nucleus. Is expressed in early conceptus and ovary. Orthologous to human WDR82 (WD repeat domain 82). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: DNA-templated transcription termination, RNA polymerase II promoter clearance, gene expression, lncRNA catabolic process, negative regulation of DNA-templated transcription, elongation, negative regulation of lncRNA transcription, nuclear RNA surveillance, positive regulation of transcription elongation by RNA polymerase II; MF: chromatin binding, lncRNA binding, protein binding; CC: PTW/PP1 phosphatase complex, Set1C/COMPASS complex, chromatin, chromosome, chromosome, telomeric region, cytoplasm, histone methyltransferase complex, nucleolus, nucleus
Pathways: Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of gene expression, Formation of WDR5-containing histone-modifying complexes, Gene expression (Transcription), Metabolism of RNA, Nuclear RNA decay, mRNA surveillance pathway - Mus musculus (mouse)
UniProt: Q8BFQ4
Entrez ID: 77305
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Rps12
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Rps12 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Rps12 (ribosomal protein S12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translation, maintenance of translational fidelity, positive regulation of canonical Wnt signaling pathway, ribosomal small subunit biogenesis, translation, translation at postsynapse, translation at presynapse; MF: structural constituent of ribosome; CC: Golgi apparatus, cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, cytosolic small ribosomal subunit, nucleolus, nucleus, postsynapse, presynapse, ribonucleoprotein complex, ribosome, small-subunit processome, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosomal scanning and start codon recognition, Ribosome - Mus musculus (mouse), Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, Translation initiation complex formation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P63323
Entrez ID: 20042
|
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