prompt string | hit int64 | screen_id int64 | crispr_strategy string | gene string | phenotype string | cell_type string | gene_context string |
|---|---|---|---|---|---|---|---|
Does Knockout of CAP1 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 334 | Knockout | CAP1 | cell proliferation | Esophageal Squamous Cell Carcinoma Cell Line | Gene: CAP1 (cyclase associated actin cytoskeleton regulatory protein 1)
Type: protein-coding
Summary: The protein encoded by this gene is related to the S. cerevisiae CAP protein, which is involved in the cyclic AMP pathway. The human protein is able to interact with other molecules of the same protein,... |
Does Knockout of UQCRH in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 149 | Knockout | UQCRH | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: UQCRH (ubiquinol-cytochrome c reductase hinge protein)
Type: protein-coding
Summary: Predicted to enable ubiquinol-cytochrome-c reductase activity. Predicted to be involved in mitochondrial electron transport, ubiquinol to cytochrome c. Located in mitochondrion. [provided by Alliance of Genome Res... |
Does Knockout of AGAP5 in Melanoma Cell Line causally result in cell proliferation? | 1 | 527 | Knockout | AGAP5 | cell proliferation | Melanoma Cell Line | Gene: AGAP5 (ArfGAP with GTPase domain, ankyrin repeat and PH domain 5)
Type: protein-coding
Summary: Predicted to enable GTPase activator activity and metal ion binding activity. Predicted to be involved in regulation of catalytic activity. Predicted to be active in nucleus. [provided by Alliance of Ge... |
Does Knockout of GFPT1 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 80 | Knockout | GFPT1 | cell proliferation | Monocytic Leukemia Cell Line | Gene: GFPT1 (glutamine--fructose-6-phosphate transaminase 1)
Type: protein-coding
Summary: This gene encodes the first and rate-limiting enzyme of the hexosamine pathway and controls the flux of glucose into the hexosamine pathway. The product of this gene catalyzes the formation of glucosamine 6-phosph... |
Does Knockout of JDP2 in Endometrial Cancer Cell Line causally result in cell proliferation? | 0 | 287 | Knockout | JDP2 | cell proliferation | Endometrial Cancer Cell Line | Gene: JDP2 (Jun dimerization protein 2)
Type: protein-coding
Summary: Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Predicted to be part o... |
Does Knockout of ZSCAN10 in Renal Cancer Cell Line causally result in cell proliferation? | 0 | 319 | Knockout | ZSCAN10 | cell proliferation | Renal Cancer Cell Line | Gene: ZSCAN10 (zinc finger and SCAN domain containing 10)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regul... |
Does Knockout of TBCD in Large Cell Lung Cancer Cell Line causally result in cell proliferation? | 1 | 734 | Knockout | TBCD | cell proliferation | Large Cell Lung Cancer Cell Line | Gene: TBCD (tubulin folding cofactor D)
Type: protein-coding
Summary: Cofactor D is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta... |
Does Knockout of C11orf65 in Ovarian Cancer Cell Line causally result in cell proliferation? | 0 | 699 | Knockout | C11orf65 | cell proliferation | Ovarian Cancer Cell Line | Gene: C11orf65 (chromosome 11 open reading frame 65)
Type: protein-coding
Summary: Predicted to be involved in negative regulation of mitochondrial fission and negative regulation of protein targeting to mitochondrion. Predicted to be located in cytosol and mitochondrial outer membrane. [provided by All... |
Does Knockout of ATXN7L3B in Lymphoma or Leukaemia Cell Line causally result in protein/peptide accumulation? | 0 | 1,218 | Knockout | ATXN7L3B | protein/peptide accumulation | Lymphoma or Leukaemia Cell Line | Gene: ATXN7L3B (ataxin 7 like 3B)
Type: protein-coding
Summary: Involved in regulation of gene expression. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: regulation of gene expression; CC: cytoplasm
Pathways:
UniProt: Q96GX2
... |
Does Knockout of ZNF721 in Lung Cancer Cell Line causally result in response to virus? | 0 | 1,433 | Knockout | ZNF721 | response to virus | Lung Cancer Cell Line | Gene: ZNF721 (zinc finger protein 721)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by... |
Does Knockout of ANKRA2 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 815 | Knockout | ANKRA2 | cell proliferation | Colonic Cancer Cell Line | Gene: ANKRA2 (ankyrin repeat family A member 2)
Type: protein-coding
Summary: Enables enzyme binding activity and low-density lipoprotein particle receptor binding activity. Involved in regulation of protein-containing complex assembly. Located in cytosol and membrane. Part of protein-containing complex... |
Does Knockout of PDE4B in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 951 | Knockout | PDE4B | cell proliferation | Colonic Cancer Cell Line | Gene: PDE4B (phosphodiesterase 4B)
Type: protein-coding
Summary: This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduct... |
Does Knockout of KIF5A in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals? | 0 | 2,396 | Knockout | KIF5A | response to chemicals | Chronic Myelogenous Leukemia Cell Line | Gene: KIF5A (kinesin family member 5A)
Type: protein-coding
Summary: This gene encodes a member of the kinesin family of proteins. Members of this family are part of a multisubunit complex that functions as a microtubule motor in intracellular organelle transport. Mutations in this gene cause autosomal ... |
Does Knockout of PPP2R1A in Cancer Cell Line causally result in cell proliferation? | 1 | 193 | Knockout | PPP2R1A | cell proliferation | Cancer Cell Line | Gene: PPP2R1A (protein phosphatase 2 scaffold subunit Aalpha)
Type: protein-coding
Summary: This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and divis... |
Does Knockout of CENPB in Lung Cancer Cell Line causally result in response to virus? | 0 | 1,433 | Knockout | CENPB | response to virus | Lung Cancer Cell Line | Gene: CENPB (centromere protein B)
Type: protein-coding
Summary: This gene product is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family. It contains a helix-loop-helix DNA binding motif at the... |
Does Knockout of PUS7L in Glioblastoma Cell Line causally result in cell proliferation? | 0 | 519 | Knockout | PUS7L | cell proliferation | Glioblastoma Cell Line | Gene: PUS7L (pseudouridine synthase 7 like)
Type: protein-coding
Summary: Predicted to enable pseudouridine synthase activity. Predicted to be involved in pseudouridine synthesis. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: RNA modi... |
Does Knockout of SNIP1 in Bladder Carcinoma causally result in cell proliferation? | 1 | 489 | Knockout | SNIP1 | cell proliferation | Bladder Carcinoma | Gene: SNIP1 (Smad nuclear interacting protein 1)
Type: protein-coding
Summary: This gene encodes a protein that contains a coiled-coil motif and C-terminal forkhead-associated (FHA) domain. The encoded protein functions as a transcriptional coactivator that increases c-Myc activity and inhibits transfor... |
Does Knockout of FAM25BP in Hepatoma Cell Line causally result in response to virus? | 0 | 2,437 | Knockout | FAM25BP | response to virus | Hepatoma Cell Line | Gene: FAM25BP (protein FAM25)
Type: pseudo
Summary: protein FAM25
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 100132929 |
Does Knockout of MTBP in Prostate Cancer Cell Line causally result in response to chemicals? | 1 | 2,109 | Knockout | MTBP | response to chemicals | Prostate Cancer Cell Line | Gene: MTBP (MDM2 binding protein)
Type: protein-coding
Summary: This gene encodes a protein that interacts with the oncoprotein mouse double minute 2. The encoded protein regulates progression through the cell cycle and may be involved in tumor formation. [provided by RefSeq, Aug 2012].
Gene On... |
Does Knockout of LPCAT3 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 206 | Knockout | LPCAT3 | cell proliferation | Monocytic Leukemia Cell Line | Gene: LPCAT3 (lysophosphatidylcholine acyltransferase 3)
Type: protein-coding
Summary: Enables 1-acylglycerophosphocholine O-acyltransferase activity; 1-acylglycerophosphoethanolamine O-acyltransferase activity; and 1-acylglycerophosphoserine O-acyltransferase activity. Involved in phosphatidylcholine a... |
Does Knockout of SOX18 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 0 | 2,114 | Knockout | SOX18 | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: SOX18 (SRY-box transcription factor 18)
Type: protein-coding
Summary: This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcri... |
Does Knockout of CLDND2 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 1,352 | Knockout | CLDND2 | response to chemicals | Cervical Adenocarcinoma Cell Line | Gene: CLDND2 (claudin domain containing 2)
Type: protein-coding
Summary: Predicted to be integral component of membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: membrane, plasma membrane
Pathways:
UniP... |
Does Knockout of SIN3A in Glioblastoma Cell Line causally result in cell proliferation? | 1 | 906 | Knockout | SIN3A | cell proliferation | Glioblastoma Cell Line | Gene: SIN3A (SIN3 transcription regulator family member A)
Type: protein-coding
Summary: The protein encoded by this gene is a transcriptional regulatory protein. It contains paired amphipathic helix (PAH) domains, which are important for protein-protein interactions and may mediate repression by the Ma... |
Does Knockout of TFPT in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 1 | 1,246 | Knockout | TFPT | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: TFPT (TCF3 fusion partner)
Type: protein-coding
Summary: Predicted to enable DNA binding activity and protein kinase binding activity. Involved in apoptotic signaling pathway. Located in nucleoplasm. Part of Ino80 complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology... |
Does Knockout of PSMD14 in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 408 | Knockout | PSMD14 | cell proliferation | Medulloblastoma Cell Line | Gene: PSMD14 (proteasome 26S subunit, non-ATPase 14)
Type: protein-coding
Summary: This gene encodes a component of the 26S proteasome. The 26S proteasome is a large multiprotein complex that catalyzes the degradation of ubiquitinated intracellular proteins. The encoded protein is a component of the 19S... |
Does Knockout of DNAJC11 in Endometrial Cancer Cell Line causally result in cell proliferation? | 1 | 758 | Knockout | DNAJC11 | cell proliferation | Endometrial Cancer Cell Line | Gene: DNAJC11 (DnaJ heat shock protein family (Hsp40) member C11)
Type: protein-coding
Summary: Involved in cristae formation. Located in mitochondrial outer membrane and nuclear speck. Part of MIB complex. Colocalizes with MICOS complex and SAM complex. [provided by Alliance of Genome Resources, Apr 20... |
Does Knockout of HES5 in Gastric Cancer Cell Line causally result in cell proliferation? | 0 | 787 | Knockout | HES5 | cell proliferation | Gastric Cancer Cell Line | Gene: HES5 (hes family bHLH transcription factor 5)
Type: protein-coding
Summary: This gene encodes a member of a family of basic helix-loop-helix transcriptional repressors. The protein product of this gene, which is activated downstream of the Notch pathway, regulates cell differentiation in multiple ... |
Does Knockout of CORO7 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 1,736 | Knockout | CORO7 | response to chemicals | Colonic Adenocarcinoma Cell Line | Gene: CORO7 (coronin 7)
Type: protein-coding
Summary: This gene encodes a member of the coronin protein family. However, unlike other coronin proteins, it is not an actin-binding protein but rather functions as an F-actin regulator directing anterograde Golgi to endosome transport. The encoded protein h... |
Does Knockout of PLA2G10 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals? | 0 | 1,340 | Knockout | PLA2G10 | response to chemicals | Retinal Pigment Epithelium Cell Line | Gene: PLA2G10 (phospholipase A2 group X)
Type: protein-coding
Summary: This gene encodes a member of the phospholipase A2 family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the matu... |
Does Knockout of DDN in Prostate Cancer Cell Line causally result in cell proliferation? | 0 | 843 | Knockout | DDN | cell proliferation | Prostate Cancer Cell Line | Gene: DDN (dendrin)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to act upstream of or within positive regulation of transcription by R... |
Does Activation of SH2D6 in Hepatoma Cell Line causally result in response to virus? | 0 | 1,210 | Activation | SH2D6 | response to virus | Hepatoma Cell Line | Gene: SH2D6 (SH2 domain containing 6)
Type: protein-coding
Summary: Predicted to be involved in intracellular signal transduction and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene ... |
Does Knockout of SFPQ in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 1,813 | Knockout | SFPQ | cell proliferation | Medulloblastoma Cell Line | Gene: SFPQ (splicing factor proline and glutamine rich)
Type: protein-coding
Summary: Enables DNA binding activity; histone deacetylase binding activity; and protein homodimerization activity. Involved in several processes, including alternative mRNA splicing, via spliceosome; positive regulation of oxi... |
Does Knockout of ARIH1 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 1 | 1,246 | Knockout | ARIH1 | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: ARIH1 (ariadne RBR E3 ubiquitin protein ligase 1)
Type: protein-coding
Summary: Enables enzyme binding activity; ubiquitin-protein transferase activity; and zinc ion binding activity. Involved in protein ubiquitination. Located in Lewy body; cytoplasm; and nuclear body. Colocalizes with cullin-RIN... |
Does Knockout of UQCC2 in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 408 | Knockout | UQCC2 | cell proliferation | Medulloblastoma Cell Line | Gene: UQCC2 (ubiquinol-cytochrome c reductase complex assembly factor 2)
Type: protein-coding
Summary: This gene encodes a nucleoid protein localized to the mitochondria inner membrane. The encoded protein affects regulation of insulin secretion, mitochondrial ATP production, and myogenesis through modu... |
Does Knockout of SLC39A7 in Cancer Cell Line causally result in cell proliferation? | 1 | 193 | Knockout | SLC39A7 | cell proliferation | Cancer Cell Line | Gene: SLC39A7 (solute carrier family 39 member 7)
Type: protein-coding
Summary: The protein encoded by this gene transports zinc from the Golgi and endoplasmic reticulum to the cytoplasm. This transport may be important for activation of tyrosine kinases, some of which could be involved in cancer progre... |
Does Knockout of DDT in Cancer Cell Line causally result in cell proliferation? | 0 | 948 | Knockout | DDT | cell proliferation | Cancer Cell Line | Gene: DDT (D-dopachrome tautomerase)
Type: protein-coding
Summary: D-dopachrome tautomerase converts D-dopachrome into 5,6-dihydroxyindole. The DDT gene is related to the migration inhibitory factor (MIF) in terms of sequence, enzyme activity, and gene structure. DDT and MIF are closely linked on chromo... |
Does Knockout of TTLL12 in Urinary Bladder Cancer Cell Line causally result in cell proliferation? | 0 | 180 | Knockout | TTLL12 | cell proliferation | Urinary Bladder Cancer Cell Line | Gene: TTLL12 (tubulin tyrosine ligase like 12)
Type: protein-coding
Summary: Enables H4K20me3 modified histone binding activity and tubulin binding activity. Involved in negative regulation of type I interferon-mediated signaling pathway and regulation of mitotic cell cycle. Located in cytoplasm. [provi... |
Does Knockout of AKR1C3 in Monocytic Leukemia Cell Line causally result in RNA accumulation? | 0 | 1,968 | Knockout | AKR1C3 | RNA accumulation | Monocytic Leukemia Cell Line | Gene: AKR1C3 (aldo-keto reductase family 1 member C3)
Type: protein-coding
Summary: This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols... |
Does Knockout of ITM2A in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 0 | 2,114 | Knockout | ITM2A | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: ITM2A (integral membrane protein 2A)
Type: protein-coding
Summary: This gene encodes a type II membrane protein that belongs to the ITM2 family. Studies in mouse suggest that it may be involved in osteo- and chondrogenic differentiation. Alternatively spliced transcript variants encoding different... |
Does Knockout of TUBGCP4 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 0 | 149 | Knockout | TUBGCP4 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: TUBGCP4 (tubulin gamma complex component 4)
Type: protein-coding
Summary: This gene encodes a component of the gamma-tubulin ring complex, which is required for microtubule nucleation. In mammalian cells, the protein localizes to centrosomes in association with gamma-tubulin. Crystal structure ana... |
Does Knockout of MAGEB10 in Neuroblastoma Cell Line causally result in cell proliferation? | 0 | 824 | Knockout | MAGEB10 | cell proliferation | Neuroblastoma Cell Line | Gene: MAGEB10 (MAGE family member B10)
Type: protein-coding
Summary: This gene encodes a member of the B subfamily of the melanoma associated antigen protein family. The encoded protein is specifically expressed in testis and tumor cells. [provided by RefSeq, Apr 2010].
Gene Ontology:
... |
Does Knockout of RPE in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 1 | 1,246 | Knockout | RPE | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: RPE (ribulose-5-phosphate-3-epimerase)
Type: protein-coding
Summary: Enables metal ion binding activity; protein homodimerization activity; and ribulose-phosphate 3-epimerase activity. Involved in carbohydrate metabolic process and pentose-phosphate shunt. Located in extracellular exosome. [provid... |
Does Knockout of RIPPLY2 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 1,352 | Knockout | RIPPLY2 | response to chemicals | Cervical Adenocarcinoma Cell Line | Gene: RIPPLY2 (ripply transcriptional repressor 2)
Type: protein-coding
Summary: This gene encodes a nuclear protein that belongs to a novel family of proteins required for vertebrate somitogenesis. Members of this family have a tetrapeptide WRPW motif that is required for interaction with the transcrip... |
Does Knockout of LRTOMT in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 427 | Knockout | LRTOMT | cell proliferation | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: LRTOMT (leucine rich transmembrane and O-methyltransferase domain containing)
Type: protein-coding
Summary: This locus represents naturally occurring readthrough transcription between the neighboring LRRC51 (leucine-rich repeat containing 51) and TOMT (transmembrane O-methyltransferase) genes on c... |
Does Knockout of LONP1 in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 1,311 | Knockout | LONP1 | cell proliferation | Oral Squamous Cell Carcinoma Cell Line | Gene: LONP1 (lon peptidase 1, mitochondrial)
Type: protein-coding
Summary: This gene encodes a mitochondrial matrix protein that belongs to the Lon family of ATP-dependent proteases. This protein mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides in the mito... |
Does Knockout of COG3 in Multiple Myeloma Cell Line causally result in cell proliferation? | 1 | 816 | Knockout | COG3 | cell proliferation | Multiple Myeloma Cell Line | Gene: COG3 (component of oligomeric golgi complex 3)
Type: protein-coding
Summary: This gene encodes a component of the conserved oligomeric Golgi (COG) complex which is composed of eight different subunits and is required for normal Golgi morphology and localization. Defects in the COG complex result i... |
Does Knockout of SOX13 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals? | 0 | 1,339 | Knockout | SOX13 | response to chemicals | Retinal Pigment Epithelium Cell Line | Gene: SOX13 (SRY-box transcription factor 13)
Type: protein-coding
Summary: This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The encoded protein may act as a transcriptio... |
Does Knockout of SERF2 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 865 | Knockout | SERF2 | cell proliferation | Colonic Cancer Cell Line | Gene: SERF2 (small EDRK-rich factor 2)
Type: protein-coding
Summary: Involved in protein destabilization. Predicted to be located in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: cytosol, nucleus
Pathways:
UniProt: P84101
... |
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