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string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of CAP1 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 334
|
Knockout
|
CAP1
|
cell proliferation
|
Esophageal Squamous Cell Carcinoma Cell Line
|
Gene: CAP1 (cyclase associated actin cytoskeleton regulatory protein 1)
Type: protein-coding
Summary: The protein encoded by this gene is related to the S. cerevisiae CAP protein, which is involved in the cyclic AMP pathway. The human protein is able to interact with other molecules of the same protein, as well as with CAP2 and actin. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2016].
Gene Ontology: BP: actin cytoskeleton organization, actin filament organization, activation of adenylate cyclase activity, ameboidal-type cell migration, cAMP-mediated signaling, cell morphogenesis, cytoskeleton organization, establishment or maintenance of cell polarity, modification of postsynaptic actin cytoskeleton, receptor-mediated endocytosis, signal transduction; MF: actin binding, adenylate cyclase binding, protein binding; CC: azurophil granule lumen, cortical actin cytoskeleton, cytoplasm, extracellular exosome, extracellular region, focal adhesion, glutamatergic synapse, membrane, plasma membrane, postsynapse, presynapse
Pathways: Angiopoietin Like Protein 8 Regulatory Pathway, Axon guidance, Developmental Biology, Hemostasis, Immune System, Innate Immune System, Insulin Signaling, Nervous system development, Neutrophil degranulation, Platelet activation, signaling and aggregation, Platelet degranulation , Response to elevated platelet cytosolic Ca2+, Role of ABL in ROBO-SLIT signaling, Signaling by ROBO receptors, how progesterone initiates the oocyte maturation
UniProt: Q01518
Entrez ID: 10487
|
Does Knockout of UQCRH in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 149
|
Knockout
|
UQCRH
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: UQCRH (ubiquinol-cytochrome c reductase hinge protein)
Type: protein-coding
Summary: Predicted to enable ubiquinol-cytochrome-c reductase activity. Predicted to be involved in mitochondrial electron transport, ubiquinol to cytochrome c. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: aerobic respiration, cellular respiration, mitochondrial electron transport, ubiquinol to cytochrome c, oxidative phosphorylation, proton transmembrane transport; MF: protein binding, quinol-cytochrome-c reductase activity; CC: membrane, mitochondrial inner membrane, mitochondrion, respiratory chain complex, respiratory chain complex III
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Cardiac muscle contraction - Homo sapiens (human), Complex III assembly, Diabetic cardiomyopathy - Homo sapiens (human), Electron Transport Chain (OXPHOS system in mitochondria), Huntington disease - Homo sapiens (human), Metabolism, Mitochondrial complex III assembly, Non-alcoholic fatty liver disease - Homo sapiens (human), Nonalcoholic fatty liver disease, Oxidative phosphorylation - Homo sapiens (human), Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Prion disease - Homo sapiens (human), Respiratory electron transport, Thermogenesis - Homo sapiens (human)
UniProt: P07919
Entrez ID: 7388
|
Does Knockout of AGAP5 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 527
|
Knockout
|
AGAP5
|
cell proliferation
|
Melanoma Cell Line
|
Gene: AGAP5 (ArfGAP with GTPase domain, ankyrin repeat and PH domain 5)
Type: protein-coding
Summary: Predicted to enable GTPase activator activity and metal ion binding activity. Predicted to be involved in regulation of catalytic activity. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: GTPase activator activity, GTPase activity, metal ion binding, zinc ion binding
Pathways: Endocytosis - Homo sapiens (human)
UniProt: A6NIR3
Entrez ID: 729092
|
Does Knockout of GFPT1 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 80
|
Knockout
|
GFPT1
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: GFPT1 (glutamine--fructose-6-phosphate transaminase 1)
Type: protein-coding
Summary: This gene encodes the first and rate-limiting enzyme of the hexosamine pathway and controls the flux of glucose into the hexosamine pathway. The product of this gene catalyzes the formation of glucosamine 6-phosphate. [provided by RefSeq, Sep 2008].
Gene Ontology: BP: UDP-N-acetylglucosamine biosynthetic process, UDP-N-acetylglucosamine metabolic process, carbohydrate derivative biosynthetic process, carbohydrate derivative metabolic process, circadian regulation of gene expression, energy reserve metabolic process, fructose 6-phosphate metabolic process, protein N-linked glycosylation, rhythmic process; MF: carbohydrate derivative binding, glutamine-fructose-6-phosphate transaminase (isomerizing) activity, protein binding, transaminase activity, transferase activity; CC: cytosol, extracellular exosome
Pathways: 2-Hydroxyglutric Aciduria (D And L Form), 4-Hydroxybutyric Aciduria/Succinic Semialdehyde Dehydrogenase Deficiency, Alanine, aspartate and glutamate metabolism - Homo sapiens (human), Amino Sugar Metabolism, Amino sugar and nucleotide sugar metabolism - Homo sapiens (human), Asparagine N-linked glycosylation, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, Cellular responses to stimuli, Cellular responses to stress, Defective GFPT1 causes CMSTA1, Diabetic cardiomyopathy - Homo sapiens (human), Disease, Diseases associated with glycosylation precursor biosynthesis, Diseases of glycosylation, Diseases of metabolism, G(M2)-Gangliosidosis: Variant B, Tay-sachs disease, Glutamate Metabolism, Homocarnosinosis, Hyperinsulinism-Hyperammonemia Syndrome, IRE1alpha activates chaperones, Insulin resistance - Homo sapiens (human), Metabolism of proteins, Post-translational protein modification, Salla Disease/Infantile Sialic Acid Storage Disease, Sialuria or French Type Sialuria, Succinic semialdehyde dehydrogenase deficiency, Synthesis of UDP-N-acetyl-glucosamine, Synthesis of substrates in N-glycan biosythesis, Tay-Sachs Disease, UDP-<i>N</i>-acetyl-D-glucosamine biosynthesis II, Unfolded Protein Response (UPR), XBP1(S) activates chaperone genes
UniProt: Q06210
Entrez ID: 2673
|
Does Knockout of JDP2 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 0
| 287
|
Knockout
|
JDP2
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: JDP2 (Jun dimerization protein 2)
Type: protein-coding
Summary: Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: chromatin remodeling, fat cell differentiation, negative regulation of fat cell differentiation, negative regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, cAMP response element binding, chromatin binding, histone chaperone activity, histone deacetylase binding, leucine zipper domain binding, protein binding, protein heterodimerization activity, protein homodimerization activity, sequence-specific double-stranded DNA binding; CC: RNA polymerase II transcription regulator complex, chromatin, nucleus
Pathways: ATF-2 transcription factor network
UniProt: Q8WYK2
Entrez ID: 122953
|
Does Knockout of ZSCAN10 in Renal Cancer Cell Line causally result in cell proliferation?
| 0
| 319
|
Knockout
|
ZSCAN10
|
cell proliferation
|
Renal Cancer Cell Line
|
Gene: ZSCAN10 (zinc finger and SCAN domain containing 10)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription, DNA-templated and regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: negative regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding, sequence-specific DNA binding, zinc ion binding; CC: nucleoplasm, nucleus
Pathways: Developmental Biology, Transcriptional regulation of pluripotent stem cells
UniProt: Q96SZ4
Entrez ID: 84891
|
Does Knockout of TBCD in Large Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 734
|
Knockout
|
TBCD
|
cell proliferation
|
Large Cell Lung Cancer Cell Line
|
Gene: TBCD (tubulin folding cofactor D)
Type: protein-coding
Summary: Cofactor D is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: adherens junction assembly, bicellular tight junction assembly, cell morphogenesis involved in neuron differentiation, microtubule cytoskeleton organization, mitotic cell cycle, negative regulation of cell-substrate adhesion, negative regulation of microtubule polymerization, post-chaperonin tubulin folding pathway, protein folding, tubulin complex assembly; MF: GTPase activator activity, beta-tubulin binding, protein binding, protein-folding chaperone binding; CC: adherens junction, anchoring junction, bicellular tight junction, centrosome, cytoplasm, cytoskeleton, lateral plasma membrane, membrane, microtubule, plasma membrane
Pathways: Metabolism of proteins, Post-chaperonin tubulin folding pathway, Protein folding
UniProt: Q9BTW9
Entrez ID: 6904
|
Does Knockout of C11orf65 in Ovarian Cancer Cell Line causally result in cell proliferation?
| 0
| 699
|
Knockout
|
C11orf65
|
cell proliferation
|
Ovarian Cancer Cell Line
|
Gene: C11orf65 (chromosome 11 open reading frame 65)
Type: protein-coding
Summary: Predicted to be involved in negative regulation of mitochondrial fission and negative regulation of protein targeting to mitochondrion. Predicted to be located in cytosol and mitochondrial outer membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: negative regulation of mitochondrial fission, negative regulation of protein targeting to mitochondrion; CC: cytoplasm, cytosol, membrane, mitochondrial outer membrane, mitochondrion
Pathways:
UniProt: Q8NCR3
Entrez ID: 160140
|
Does Knockout of ATXN7L3B in Lymphoma or Leukaemia Cell Line causally result in protein/peptide accumulation?
| 0
| 1,218
|
Knockout
|
ATXN7L3B
|
protein/peptide accumulation
|
Lymphoma or Leukaemia Cell Line
|
Gene: ATXN7L3B (ataxin 7 like 3B)
Type: protein-coding
Summary: Involved in regulation of gene expression. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: regulation of gene expression; CC: cytoplasm
Pathways:
UniProt: Q96GX2
Entrez ID: 552889
|
Does Knockout of ZNF721 in Lung Cancer Cell Line causally result in response to virus?
| 0
| 1,433
|
Knockout
|
ZNF721
|
response to virus
|
Lung Cancer Cell Line
|
Gene: ZNF721 (zinc finger protein 721)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: DNA binding, metal ion binding, zinc ion binding; CC: nuclear lumen, nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Homo sapiens (human), RNA Polymerase II Transcription
UniProt: Q8TF20
Entrez ID: 170960
|
Does Knockout of ANKRA2 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 815
|
Knockout
|
ANKRA2
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: ANKRA2 (ankyrin repeat family A member 2)
Type: protein-coding
Summary: Enables enzyme binding activity and low-density lipoprotein particle receptor binding activity. Involved in regulation of protein-containing complex assembly. Located in cytosol and membrane. Part of protein-containing complex. Colocalizes with 3M complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: regulation of gene expression, regulation of protein-containing complex assembly; MF: histone deacetylase binding, low-density lipoprotein particle receptor binding, protein binding, protein kinase binding, ubiquitin protein ligase binding; CC: 3M complex, cytoplasm, cytoskeleton, cytosol, membrane, nucleus, protein-containing complex
Pathways: Signaling events mediated by HDAC Class II
UniProt: Q9H9E1
Entrez ID: 57763
|
Does Knockout of PDE4B in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 951
|
Knockout
|
PDE4B
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: PDE4B (phosphodiesterase 4B)
Type: protein-coding
Summary: This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014].
Gene Ontology: BP: T cell receptor signaling pathway, cAMP catabolic process, cellular response to epinephrine stimulus, cellular response to lipopolysaccharide, cellular response to xenobiotic stimulus, leukocyte migration, negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway, negative regulation of cAMP/PKA signal transduction, negative regulation of relaxation of cardiac muscle, neutrophil chemotaxis, neutrophil homeostasis, positive regulation of interleukin-2 production, positive regulation of type II interferon production, regulation of calcium ion transmembrane transport via high voltage-gated calcium channel, regulation of cardiac muscle cell contraction, signal transduction; MF: 3',5'-cyclic-AMP phosphodiesterase activity, 3',5'-cyclic-GMP phosphodiesterase activity, 3',5'-cyclic-nucleotide phosphodiesterase activity, cAMP binding, calcium channel regulator activity, gamma-tubulin binding, hydrolase activity, metal ion binding, phosphoric diester hydrolase activity, protein binding, transmembrane transporter binding; CC: Z disc, cell periphery, centrosome, cytoplasm, cytosol, dendritic spine, excitatory synapse, gamma-tubulin complex, membrane, plasma membrane, postsynaptic density, synaptic vesicle, voltage-gated calcium channel complex
Pathways: DARPP-32 events, G Protein Signaling Pathways, G alpha (i) signalling events, GPCR downstream signalling, Glucocorticoid Receptor Pathway, Morphine addiction - Homo sapiens (human), Myometrial relaxation and contraction pathways, Nuclear Receptors Meta-Pathway, Opioid Signalling, Parathyroid hormone synthesis, secretion and action - Homo sapiens (human), Phosphodiesterases in neuronal function, Purine metabolism - Homo sapiens (human), Signal Transduction, Signaling by GPCR, cAMP signaling pathway - Homo sapiens (human)
UniProt: Q07343
Entrez ID: 5142
|
Does Knockout of KIF5A in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals?
| 0
| 2,396
|
Knockout
|
KIF5A
|
response to chemicals
|
Chronic Myelogenous Leukemia Cell Line
|
Gene: KIF5A (kinesin family member 5A)
Type: protein-coding
Summary: This gene encodes a member of the kinesin family of proteins. Members of this family are part of a multisubunit complex that functions as a microtubule motor in intracellular organelle transport. Mutations in this gene cause autosomal dominant spastic paraplegia 10. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: anterograde axonal protein transport, anterograde dendritic transport of neurotransmitter receptor complex, axon guidance, chemical synaptic transmission, microtubule-based movement, retrograde neuronal dense core vesicle transport, synaptic vesicle transport, vesicle-mediated transport; MF: ATP binding, ATP hydrolysis activity, cytoskeletal motor activity, hydrolase activity, isomerase activity, kinesin binding, microtubule binding, microtubule motor activity, nucleotide binding, plus-end-directed microtubule motor activity, protein binding; CC: axon cytoplasm, ciliary rootlet, cytoplasm, cytoskeleton, cytosol, dendrite cytoplasm, kinesin complex, membrane, microtubule, neuron projection, neuronal cell body, perikaryon, perinuclear region of cytoplasm, postsynaptic cytosol
Pathways: Adaptive Immune System, Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), COPI-dependent Golgi-to-ER retrograde traffic, Dopaminergic synapse - Homo sapiens (human), Endocytosis - Homo sapiens (human), Factors involved in megakaryocyte development and platelet production, Golgi-to-ER retrograde transport, Hemostasis, Huntington disease - Homo sapiens (human), Immune System, Insulin processing, Intra-Golgi and retrograde Golgi-to-ER traffic, Kinesins, MHC class II antigen presentation, Membrane Trafficking, Metabolism of proteins, Non-small cell lung cancer - Homo sapiens (human), Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Peptide hormone metabolism, Prion disease - Homo sapiens (human), RHO GTPase Effectors, RHO GTPases activate KTN1, Salmonella infection - Homo sapiens (human), Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Vesicle-mediated transport
UniProt: Q12840
Entrez ID: 3798
|
Does Knockout of PPP2R1A in Cancer Cell Line causally result in cell proliferation?
| 1
| 193
|
Knockout
|
PPP2R1A
|
cell proliferation
|
Cancer Cell Line
|
Gene: PPP2R1A (protein phosphatase 2 scaffold subunit Aalpha)
Type: protein-coding
Summary: This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010].
Gene Ontology: BP: RNA polymerase II transcription initiation surveillance, T cell homeostasis, chromosome segregation, female meiotic nuclear division, intracellular signal transduction, meiotic sister chromatid cohesion, centromeric, meiotic spindle elongation, mitotic sister chromatid separation, negative regulation of hippo signaling, negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of extrinsic apoptotic signaling pathway in absence of ligand, protein-containing complex assembly, regulation of cell differentiation, regulation of growth, regulation of meiotic cell cycle process involved in oocyte maturation, spindle assembly, transcription by RNA polymerase II, transcription elongation by RNA polymerase II; MF: protein antigen binding, protein binding, protein heterodimerization activity, protein phosphatase regulator activity, protein serine/threonine phosphatase activity; CC: FAR/SIN/STRIPAK complex, INTAC complex, cell projection, chromatin, chromosome, chromosome, centromeric region, cytoplasm, cytosol, dendrite, extracellular exosome, glutamatergic synapse, lateral plasma membrane, membrane, microtubule cytoskeleton, mitochondrion, neuron projection, neuronal cell body, nucleus, plasma membrane, protein phosphatase type 2A complex, synapse
Pathways: 16p11.2 proximal deletion syndrome, AMPK signaling pathway - Homo sapiens (human), APC truncation mutants have impaired AXIN binding, ATR signaling pathway, AURKA Activation by TPX2, AXIN missense mutants destabilize the destruction complex, Adaptive Immune System, Adrenergic signaling in cardiomyocytes - Homo sapiens (human), Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Anchoring of the basal body to the plasma membrane, Antiviral mechanism by IFN-stimulated genes, Beta-catenin phosphorylation cascade, CTNNB1 S33 mutants aren't phosphorylated, CTNNB1 S37 mutants aren't phosphorylated, CTNNB1 S45 mutants aren't phosphorylated, CTNNB1 T41 mutants aren't phosphorylated, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cellular responses to mechanical stimuli, Cellular responses to stimuli, Centrosome maturation, Chagas disease - Homo sapiens (human), Cilium Assembly, Co-inhibition by CTLA4, Co-stimulation by CD28, Cyclin A/B1/B2 associated events during G2/M transition, Cyclin D associated events in G1, Cytokine Signaling in Immune system, DARPP-32 events, Degradation of beta-catenin by the destruction complex, Disassembly of the destruction complex and recruitment of AXIN to the membrane, Disease, Diseases of signal transduction by growth factor receptors and second messengers, Dopaminergic synapse - Homo sapiens (human), E2F mediated regulation of DNA replication, EML4 and NUDC in mitotic spindle formation, ERK/MAPK targets, ERKs are inactivated, ErbB1 downstream signaling, Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, G alpha (i) signalling events, G1 Phase, G1/S Transition, G2/M Transition, GPCR downstream signalling, Gene expression (Transcription), Generic Transcription Pathway, Glucose metabolism, Glycogen Synthesis and Degradation, Glycolysis, Hemostasis, Hepatitis C - Homo sapiens (human), Hippo signaling pathway - Homo sapiens (human), Human papillomavirus infection - Homo sapiens (human), IL8- and CXCR2-mediated signaling events, Immune System, Inhibition of replication initiation of damaged DNA by RB1/E2F1, Initiation of Nuclear Envelope (NE) Reformation, Innate Immune System, Integration of energy metabolism, Interferon Signaling, Interleukin-17 signaling, Intracellular signaling by second messengers, Long-term depression - Homo sapiens (human), Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, MAP kinase activation, MAPK family signaling cascades, MAPK targets/ Nuclear events mediated by MAP kinases, MAPK1/MAPK3 signaling, MASTL Facilitates Mitotic Progression, Metabolism, Metabolism of RNA, Metabolism of carbohydrates and carbohydrate derivatives, Mitotic Anaphase, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Prophase, Mitotic Spindle Checkpoint, MyD88 cascade initiated on plasma membrane, MyD88 dependent cascade initiated on endosome, MyD88-independent TLR4 cascade , MyD88:MAL(TIRAP) cascade initiated on plasma membrane, Negative regulation of FGFR1 signaling, Negative regulation of FGFR2 signaling, Negative regulation of FGFR3 signaling, Negative regulation of FGFR4 signaling, Negative regulation of MAPK pathway, Negative regulation of the PI3K/AKT network, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), Nuclear Envelope (NE) Reassembly, Nuclear Events (kinase and transcription factor activation), Oocyte meiosis - Homo sapiens (human), Opioid Signalling, Organelle biogenesis and maintenance, PDGFR-beta signaling pathway, PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, PIP3 activates AKT signaling, PKR-mediated signaling, PLK1 signaling events, PP2A-mediated dephosphorylation of key metabolic factors, Platelet homeostasis, Platelet sensitization by LDL, RAF activation, RAF/MAP kinase cascade, RHO GTPase Effectors, RHO GTPases Activate Formins, RNA Polymerase II Transcription, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Regulation of PLK1 Activity at G2/M Transition, Regulation of T cell activation by CD28 family, Regulation of TP53 Activity, Regulation of TP53 Degradation, Regulation of TP53 Expression and Degradation, Regulation of glycolysis by fructose 2,6-bisphosphate metabolism, Resolution of Sister Chromatid Cohesion, Response of endothelial cells to shear stress, Separation of Sister Chromatids, Signal Transduction, Signaling by AMER1 mutants, Signaling by APC mutants, Signaling by AXIN mutants, Signaling by CTNNB1 phospho-site mutants, Signaling by FGFR, Signaling by FGFR1, Signaling by FGFR2, Signaling by FGFR3, Signaling by FGFR4, Signaling by GPCR, Signaling by GSK3beta mutants, Signaling by Interleukins, Signaling by NTRK1 (TRKA), Signaling by NTRKs, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by WNT, Signaling by WNT in cancer, Sphingolipid signaling pathway - Homo sapiens (human), Spry regulation of FGF signaling, TCF dependent signaling in response to WNT, TGF-beta signaling pathway - Homo sapiens (human), TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, TRIF (TICAM1)-mediated TLR4 signaling , Tight junction - Homo sapiens (human), Toll Like Receptor 10 (TLR10) Cascade, Toll Like Receptor 2 (TLR2) Cascade, Toll Like Receptor 3 (TLR3) Cascade, Toll Like Receptor 4 (TLR4) Cascade, Toll Like Receptor 5 (TLR5) Cascade, Toll Like Receptor 7/8 (TLR7/8) Cascade, Toll Like Receptor 9 (TLR9) Cascade, Toll Like Receptor TLR1:TLR2 Cascade, Toll Like Receptor TLR6:TLR2 Cascade, Toll-like Receptor Cascades, Transcriptional Regulation by TP53, Truncations of AMER1 destabilize the destruction complex, Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells, Wnt signaling pathway and pluripotency, mRNA surveillance pathway - Homo sapiens (human)
UniProt: P30153
Entrez ID: 5518
|
Does Knockout of CENPB in Lung Cancer Cell Line causally result in response to virus?
| 0
| 1,433
|
Knockout
|
CENPB
|
response to virus
|
Lung Cancer Cell Line
|
Gene: CENPB (centromere protein B)
Type: protein-coding
Summary: This gene product is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family. It contains a helix-loop-helix DNA binding motif at the N-terminus, and a dimerization domain at the C-terminus. The DNA binding domain recognizes and binds a 17-bp sequence (CENP-B box) in the centromeric alpha satellite DNA. This protein is proposed to play an important role in the assembly of specific centromere structures in interphase nuclei and on mitotic chromosomes. It is also considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies. [provided by RefSeq, Jul 2008].
Gene Ontology: MF: DNA binding, centromeric DNA binding, chromatin binding, nucleic acid binding, protein binding, satellite DNA binding, sequence-specific DNA binding; CC: chromosome, chromosome, centromeric region, condensed chromosome, centromeric region, nuclear body, nucleoplasm, nucleus, pericentric heterochromatin
Pathways: FOXM1 transcription factor network, IL-18 signaling pathway
UniProt: P07199
Entrez ID: 1059
|
Does Knockout of PUS7L in Glioblastoma Cell Line causally result in cell proliferation?
| 0
| 519
|
Knockout
|
PUS7L
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: PUS7L (pseudouridine synthase 7 like)
Type: protein-coding
Summary: Predicted to enable pseudouridine synthase activity. Predicted to be involved in pseudouridine synthesis. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: RNA modification, mRNA processing, mRNA pseudouridine synthesis, pseudouridine synthesis; MF: RNA binding, isomerase activity, protein binding, pseudouridine synthase activity
Pathways:
UniProt: Q9H0K6
Entrez ID: 83448
|
Does Knockout of SNIP1 in Bladder Carcinoma causally result in cell proliferation?
| 1
| 489
|
Knockout
|
SNIP1
|
cell proliferation
|
Bladder Carcinoma
|
Gene: SNIP1 (Smad nuclear interacting protein 1)
Type: protein-coding
Summary: This gene encodes a protein that contains a coiled-coil motif and C-terminal forkhead-associated (FHA) domain. The encoded protein functions as a transcriptional coactivator that increases c-Myc activity and inhibits transforming growth factor beta (TGF-beta) and nuclear factor kappa-B (NF-kB) signaling. The encoded protein also regulates the stability of cyclin D1 mRNA, and may play a role in cell proliferation and cancer progression. Mutations in this gene are a cause of psychomotor retardation, epilepsy, and craniofacial dysmorphism (PMRED). [provided by RefSeq, Mar 2012].
Gene Ontology: BP: RNA splicing, U2-type prespliceosome assembly, mRNA processing, mRNA splicing, via spliceosome, miRNA processing, negative regulation of canonical NF-kappaB signal transduction, regulation of gene expression, regulatory ncRNA-mediated gene silencing; MF: RNA binding, mRNA binding, protein binding, transcription regulator inhibitor activity; CC: U2 snRNP, U2-type precatalytic spliceosome, cytosol, nucleoplasm, nucleus, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Regulation of nuclear SMAD2/3 signaling, TGF-beta Signaling Pathway, TGF_beta_Receptor, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q8TAD8
Entrez ID: 79753
|
Does Knockout of FAM25BP in Hepatoma Cell Line causally result in response to virus?
| 0
| 2,437
|
Knockout
|
FAM25BP
|
response to virus
|
Hepatoma Cell Line
|
Gene: FAM25BP (protein FAM25)
Type: pseudo
Summary: protein FAM25
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 100132929
|
Does Knockout of MTBP in Prostate Cancer Cell Line causally result in response to chemicals?
| 1
| 2,109
|
Knockout
|
MTBP
|
response to chemicals
|
Prostate Cancer Cell Line
|
Gene: MTBP (MDM2 binding protein)
Type: protein-coding
Summary: This gene encodes a protein that interacts with the oncoprotein mouse double minute 2. The encoded protein regulates progression through the cell cycle and may be involved in tumor formation. [provided by RefSeq, Aug 2012].
Gene Ontology: BP: negative regulation of cell population proliferation, negative regulation of mitotic nuclear division, protein localization to kinetochore, regulation of cell cycle, regulation of protein ubiquitination, traversing start control point of mitotic cell cycle; CC: chromatin, kinetochore
Pathways: Adherens junctions interactions, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Degradation of CDH1, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion
UniProt: Q96DY7
Entrez ID: 27085
|
Does Knockout of LPCAT3 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 206
|
Knockout
|
LPCAT3
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: LPCAT3 (lysophosphatidylcholine acyltransferase 3)
Type: protein-coding
Summary: Enables 1-acylglycerophosphocholine O-acyltransferase activity; 1-acylglycerophosphoethanolamine O-acyltransferase activity; and 1-acylglycerophosphoserine O-acyltransferase activity. Involved in phosphatidylcholine acyl-chain remodeling; phosphatidylethanolamine acyl-chain remodeling; and phosphatidylserine acyl-chain remodeling. Located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: chylomicron assembly, endoplasmic reticulum membrane organization, intestinal stem cell homeostasis, lipid metabolic process, lipid modification, negative regulation of inflammatory response, negative regulation of response to endoplasmic reticulum stress, phosphatidylcholine acyl-chain remodeling, phosphatidylcholine biosynthetic process, phosphatidylethanolamine acyl-chain remodeling, phosphatidylserine acyl-chain remodeling, phospholipid biosynthetic process, phospholipid metabolic process, positive regulation of intestinal cholesterol absorption, positive regulation of triglyceride transport, regulation of cholesterol biosynthetic process, regulation of plasma lipoprotein particle levels, very-low-density lipoprotein particle assembly; MF: 1-acylglycerol-3-phosphate O-acyltransferase activity, 1-acylglycerophosphocholine O-acyltransferase activity, 1-acylglycerophosphoethanolamine O-acyltransferase activity, 1-acylglycerophosphoserine O-acyltransferase activity, 2-acylglycerol-3-phosphate O-acyltransferase activity, acyltransferase activity, lysophospholipid acyltransferase activity, transferase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Acyl chain remodelling of PC, Acyl chain remodelling of PE, Acyl chain remodelling of PS, CDP-diacylglycerol biosynthesis, Ferroptosis, Ferroptosis - Homo sapiens (human), Glycerophospholipid biosynthesis, Glycerophospholipid metabolism - Homo sapiens (human), Metabolism, Metabolism of lipids, Phospholipid metabolism, triacylglycerol biosynthesis
UniProt: Q6P1A2
Entrez ID: 10162
|
Does Knockout of SOX18 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 0
| 2,114
|
Knockout
|
SOX18
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: SOX18 (SRY-box transcription factor 18)
Type: protein-coding
Summary: This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. This protein plays a role in hair, blood vessel, and lymphatic vessel development. Mutations in this gene have been associated with recessive and dominant forms of hypotrichosis-lymphedema-telangiectasia. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: anatomical structure formation involved in morphogenesis, angiogenesis, blood vessel development, blood vessel endothelial cell migration, cell maturation, embryonic heart tube development, endocardial cell differentiation, endocardium formation, establishment of endothelial barrier, hair cycle process, hair follicle development, heart development, heart looping, in utero embryonic development, lymph vessel development, lymphangiogenesis, lymphatic endothelial cell differentiation, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, outflow tract morphogenesis, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of stem cell proliferation, stem cell fate specification, tissue development, vasculature development, vasculogenesis; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding; CC: chromatin, nucleus, transcription regulator complex
Pathways:
UniProt: P35713
Entrez ID: 54345
|
Does Knockout of CLDND2 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,352
|
Knockout
|
CLDND2
|
response to chemicals
|
Cervical Adenocarcinoma Cell Line
|
Gene: CLDND2 (claudin domain containing 2)
Type: protein-coding
Summary: Predicted to be integral component of membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: membrane, plasma membrane
Pathways:
UniProt: Q8NHS1
Entrez ID: 125875
|
Does Knockout of SIN3A in Glioblastoma Cell Line causally result in cell proliferation?
| 1
| 906
|
Knockout
|
SIN3A
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: SIN3A (SIN3 transcription regulator family member A)
Type: protein-coding
Summary: The protein encoded by this gene is a transcriptional regulatory protein. It contains paired amphipathic helix (PAH) domains, which are important for protein-protein interactions and may mediate repression by the Mad-Max complex. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA replication, activation of innate immune response, cellular response to dopamine, cellular response to glucose stimulus, cellular response to tert-butyl hydroperoxide, cerebral cortex neuron differentiation, hematopoietic progenitor cell differentiation, heterochromatin formation, in utero embryonic development, intracellular protein localization, negative regulation of DNA-templated transcription, negative regulation of apoptotic process, negative regulation of cell migration, negative regulation of circadian rhythm, negative regulation of protein localization to nucleus, negative regulation of stem cell population maintenance, negative regulation of transcription by RNA polymerase II, negative regulation of transforming growth factor beta receptor signaling pathway, positive regulation of G2/M transition of mitotic cell cycle, positive regulation of defense response to virus by host, positive regulation of neuron differentiation, positive regulation of stem cell population maintenance, regulation of DNA-templated transcription, regulation of axon extension, regulation of hormone levels, response to methylglyoxal, rhythmic process, type I interferon-mediated signaling pathway; MF: DNA binding, RNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, chromatin binding, protein binding, protein-containing complex binding, transcription corepressor activity, transcription regulator inhibitor activity; CC: Sin3-type complex, chromatin, chromosome, histone deacetylase complex, kinetochore, nucleolus, nucleoplasm, nucleus, protein-containing complex, transcription regulator complex, transcription repressor complex
Pathways: Androgen receptor signaling pathway, AndrogenReceptor, C-MYB transcription factor network, Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Cytoprotection by HMOX1, Developmental Biology, Disease, Disorders of Developmental Biology, Disorders of Nervous System Development, Epigenetic regulation of gene expression, Epstein-Barr virus infection - Homo sapiens (human), FOXO-mediated transcription, FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes, Factors involved in megakaryocyte development and platelet production, Gene expression (Transcription), Generic Transcription Pathway, Hedgehog Signaling Pathway Netpath, Hedgehog signaling events mediated by Gli proteins, Hemostasis, Huntington disease - Homo sapiens (human), Loss of MECP2 binding ability to 5mC-DNA, Loss of function of MECP2 in Rett syndrome, MECP2 and Associated Rett Syndrome, MECP2 regulates neuronal receptors and channels, MECP2 regulates transcription of neuronal ligands, MITF-M-dependent gene expression, MITF-M-regulated melanocyte development, Metabolism, Metabolism of lipids, Metabolism of proteins, Negative epigenetic regulation of rRNA expression, NoRC negatively regulates rRNA expression, Pervasive developmental disorders, Post-translational protein modification, RNA Polymerase II Transcription, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function, Regulation of MECP2 expression and activity, Regulation of MITF-M-dependent genes involved in apoptosis, Regulation of MITF-M-dependent genes involved in cell cycle and proliferation, Regulation of Telomerase, Regulation of lipid metabolism by PPARalpha, Regulation of nuclear SMAD2/3 signaling, Retinoblastoma gene in cancer, STAT3 nuclear events downstream of ALK signaling, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of transcription cofactors, Signal Transduction, Signaling by ALK, Signaling by Receptor Tyrosine Kinases, Signaling events mediated by HDAC Class I, TGF-beta Signaling Pathway, Thyroid hormone signaling pathway - Homo sapiens (human), Transcription co-factors SKI and SKIL protein partners, Transcriptional Regulation by MECP2, Transcriptional misregulation in cancer - Homo sapiens (human), Transcriptional regulation by RUNX1, mets affect on macrophage differentiation
UniProt: Q96ST3
Entrez ID: 25942
|
Does Knockout of TFPT in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 1,246
|
Knockout
|
TFPT
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: TFPT (TCF3 fusion partner)
Type: protein-coding
Summary: Predicted to enable DNA binding activity and protein kinase binding activity. Involved in apoptotic signaling pathway. Located in nucleoplasm. Part of Ino80 complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, apoptotic process, apoptotic signaling pathway, chromatin remodeling, positive regulation of DNA repair, positive regulation of DNA-templated transcription, positive regulation of apoptotic process, positive regulation of telomere maintenance in response to DNA damage, regulation of DNA repair, regulation of DNA replication, regulation of DNA strand elongation, regulation of cell cycle, regulation of chromosome organization, regulation of embryonic development, telomere maintenance; MF: DNA binding, protein binding; CC: Ino80 complex, cytoplasm, nucleoplasm, nucleus
Pathways:
UniProt: P0C1Z6
Entrez ID: 29844
|
Does Knockout of PSMD14 in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 408
|
Knockout
|
PSMD14
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: PSMD14 (proteasome 26S subunit, non-ATPase 14)
Type: protein-coding
Summary: This gene encodes a component of the 26S proteasome. The 26S proteasome is a large multiprotein complex that catalyzes the degradation of ubiquitinated intracellular proteins. The encoded protein is a component of the 19S regulatory cap complex of the 26S proteasome and mediates substrate deubiquitination. A pseudogene of this gene is also located on the long arm of chromosome 2. [provided by RefSeq, Feb 2012].
Gene Ontology: BP: DNA damage response, DNA repair, double-strand break repair via homologous recombination, double-strand break repair via nonhomologous end joining, proteasome-mediated ubiquitin-dependent protein catabolic process, protein K63-linked deubiquitination, protein deubiquitination, proteolysis, regulation of proteasomal protein catabolic process, response to ethanol, ubiquitin-dependent protein catabolic process; MF: K63-linked deubiquitinase activity, endopeptidase activator activity, hydrolase activity, metal ion binding, metal-dependent deubiquitinase activity, metallopeptidase activity, peptidase activity, proteasome binding, protein binding; CC: cytosol, cytosolic proteasome complex, extracellular region, ficolin-1-rich granule lumen, nucleoplasm, nucleus, proteasome accessory complex, proteasome complex, proteasome regulatory particle, lid subcomplex, secretory granule lumen
Pathways: ABC transporter disorders, ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, AUF1 (hnRNP D0) binds and destabilizes mRNA, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Activation of NF-kappaB in B cells, Adaptive Immune System, Adherens junctions interactions, Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Antigen processing-Cross presentation, Antigen processing: Ubiquitination & Proteasome degradation, Apoptosis, Assembly of the pre-replicative complex, Asymmetric localization of PCP proteins, Autodegradation of Cdh1 by Cdh1:APC/C, Autodegradation of the E3 ubiquitin ligase COP1, Axon guidance, Beta-catenin independent WNT signaling, C-type lectin receptors (CLRs), CDK-mediated phosphorylation and removal of Cdc6, CLEC7A (Dectin-1) signaling, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cellular response to chemical stress, Cellular response to hypoxia, Cellular responses to stimuli, Cellular responses to stress, Circadian clock, Class I MHC mediated antigen processing & presentation, Co-inhibition by PD-1, Cross-presentation of soluble exogenous antigens (endosomes), Cyclin A:Cdk2-associated events at S phase entry, Cyclin E associated events during G1/S transition , Cytokine Signaling in Immune system, DNA Replication, DNA Replication Pre-Initiation, Dectin-1 mediated noncanonical NF-kB signaling, Defective CFTR causes cystic fibrosis, Degradation of AXIN, Degradation of CDH1, Degradation of CRY and PER proteins, Degradation of DVL, Degradation of GLI1 by the proteasome, Degradation of GLI2 by the proteasome, Degradation of beta-catenin by the destruction complex, Deubiquitination, Developmental Biology, Disease, Diseases of signal transduction by growth factor receptors and second messengers, Disorders of transmembrane transporters, Downstream TCR signaling, Downstream signaling events of B Cell Receptor (BCR), ER-Phagosome pathway, Epstein-Barr virus infection - Homo sapiens (human), FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, FCERI mediated NF-kB activation, Fc epsilon receptor (FCERI) signaling, Formation of paraxial mesoderm, G1/S DNA Damage Checkpoints, G1/S Transition, G2/M Checkpoints, G2/M Transition, GLI3 is processed to GLI3R by the proteasome, GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2, GSK3B-mediated proteasomal degradation of PD-L1(CD274), Gastrulation, Gene expression (Transcription), Generic Transcription Pathway, HIV Infection, Hedgehog 'off' state, Hedgehog 'on' state, Hedgehog ligand biogenesis, Hh mutants abrogate ligand secretion, Hh mutants are degraded by ERAD, Host Interactions of HIV factors, Huntington disease - Homo sapiens (human), Immune System, Infectious disease, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, Intracellular signaling by second messengers, KEAP1-NFE2L2 pathway, M Phase, MAPK family signaling cascades, MAPK1/MAPK3 signaling, MAPK6/MAPK4 signaling, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of polyamines, Metabolism of proteins, Metalloprotease DUBs, Mitotic Anaphase, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, NIK-->noncanonical NF-kB signaling, Neddylation, Negative regulation of NOTCH4 signaling, Nervous system development, Neutrophil degranulation, Nuclear events mediated by NFE2L2, Orc1 removal from chromatin, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, PCP/CE pathway, PIP3 activates AKT signaling, PTEN Regulation, Parkin-Ubiquitin Proteasomal System pathway, Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Post-translational protein modification, Prion disease - Homo sapiens (human), Programmed Cell Death, Proteasome - Homo sapiens (human), Proteasome assembly, RAF/MAP kinase cascade, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Regulation of APC/C activators between G1/S and early anaphase, Regulation of Apoptosis, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of PTEN stability and activity, Regulation of RAS by GAPs, Regulation of RUNX2 expression and activity, Regulation of RUNX3 expression and activity, Regulation of T cell activation by CD28 family, Regulation of activated PAK-2p34 by proteasome mediated degradation, Regulation of expression of SLITs and ROBOs, Regulation of mRNA stability by proteins that bind AU-rich elements, Regulation of mitotic cell cycle, Regulation of ornithine decarboxylase (ODC), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, S Phase, SCF(Skp2)-mediated degradation of p27/p21, SCF-beta-TrCP mediated degradation of Emi1, SPOP-mediated proteasomal degradation of PD-L1(CD274), Separation of Sister Chromatids, Signal Transduction, Signaling by Hedgehog, Signaling by Interleukins, Signaling by NOTCH, Signaling by NOTCH4, Signaling by ROBO receptors, Signaling by WNT, Signaling by the B Cell Receptor (BCR), Somitogenesis, Spinocerebellar ataxia - Homo sapiens (human), Stabilization of p53, Switching of origins to a post-replicative state, Synthesis of DNA, TCF dependent signaling in response to WNT, TCR signaling, TNFR2 non-canonical NF-kB pathway, The role of GTSE1 in G2/M progression after G2 checkpoint, Transcriptional regulation by RUNX1, Transcriptional regulation by RUNX2, Transcriptional regulation by RUNX3, Translation, Transport of small molecules, UCH proteinases, Ub-specific processing proteases, Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, Ubiquitin-dependent degradation of Cyclin D, Vif-mediated degradation of APOBEC3G, Viral Infection Pathways, Vpu mediated degradation of CD4, p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint, p53-Independent G1/S DNA Damage Checkpoint, proteasome complex
UniProt: O00487
Entrez ID: 10213
|
Does Knockout of DNAJC11 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 758
|
Knockout
|
DNAJC11
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: DNAJC11 (DnaJ heat shock protein family (Hsp40) member C11)
Type: protein-coding
Summary: Involved in cristae formation. Located in mitochondrial outer membrane and nuclear speck. Part of MIB complex. Colocalizes with MICOS complex and SAM complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cristae formation, inner mitochondrial membrane organization; CC: MIB complex, MICOS complex, SAM complex, membrane, mitochondrial outer membrane, mitochondrion, nuclear speck, nucleoplasm
Pathways: Cristae formation, Mitochondrial biogenesis, Organelle biogenesis and maintenance
UniProt: Q9NVH1
Entrez ID: 55735
|
Does Knockout of HES5 in Gastric Cancer Cell Line causally result in cell proliferation?
| 0
| 787
|
Knockout
|
HES5
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: HES5 (hes family bHLH transcription factor 5)
Type: protein-coding
Summary: This gene encodes a member of a family of basic helix-loop-helix transcriptional repressors. The protein product of this gene, which is activated downstream of the Notch pathway, regulates cell differentiation in multiple tissues. Disruptions in the normal expression of this gene have been associated with developmental diseases and cancer. [provided by RefSeq, Dec 2008].
Gene Ontology: BP: BMP signaling pathway, Notch signaling pathway, S-shaped body morphogenesis, animal organ development, anterior/posterior pattern specification, astrocyte differentiation, brain development, camera-type eye development, cartilage development, cell adhesion, cell differentiation, cell maturation, central nervous system myelination, central nervous system neuron differentiation, chondrocyte differentiation, comma-shaped body morphogenesis, establishment of epithelial cell polarity, glial cell fate commitment, inner ear auditory receptor cell differentiation, inner ear receptor cell stereocilium organization, metanephric nephron tubule morphogenesis, negative regulation of DNA-templated transcription, negative regulation of astrocyte differentiation, negative regulation of cell differentiation, negative regulation of inner ear auditory receptor cell differentiation, negative regulation of inner ear receptor cell differentiation, negative regulation of neuron differentiation, negative regulation of oligodendrocyte differentiation, negative regulation of pro-B cell differentiation, negative regulation of stem cell differentiation, negative regulation of transcription by RNA polymerase II, nervous system development, neural tube development, neuron differentiation, neuronal stem cell population maintenance, oligodendrocyte development, oligodendrocyte differentiation, positive regulation of BMP signaling pathway, positive regulation of DNA-templated transcription, positive regulation of Notch signaling pathway, positive regulation of cell population proliferation, positive regulation of receptor signaling pathway via JAK-STAT, positive regulation of smooth muscle cell proliferation, positive regulation of transcription by RNA polymerase II, protein-containing complex assembly, regulation of DNA-templated transcription, regulation of cell differentiation, regulation of epithelial cell proliferation, regulation of myelination, regulation of neurogenesis, regulation of neuron differentiation, regulation of transcription by RNA polymerase II, smoothened signaling pathway, specification of loop of Henle identity, system development, telencephalon development; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, protein dimerization activity, sequence-specific double-stranded DNA binding; CC: chromatin, nucleoplasm, nucleus
Pathways: Breast cancer - Homo sapiens (human), Breast cancer pathway, CDC42 signaling events, Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants, Constitutive Signaling by NOTCH1 PEST Domain Mutants, Disease, Diseases of signal transduction by growth factor receptors and second messengers, Human papillomavirus infection - Homo sapiens (human), NOTCH1 Intracellular Domain Regulates Transcription, NOTCH2 intracellular domain regulates transcription, NOTCH3 Intracellular Domain Regulates Transcription, NOTCH4 Intracellular Domain Regulates Transcription, Neural Crest Differentiation, Notch Signaling, Notch Signaling Pathway Netpath, Notch signaling pathway - Homo sapiens (human), Pathways in cancer - Homo sapiens (human), Signal Transduction, Signaling by NOTCH, Signaling by NOTCH1, Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer, Signaling by NOTCH1 PEST Domain Mutants in Cancer, Signaling by NOTCH1 in Cancer, Signaling by NOTCH2, Signaling by NOTCH3, Signaling by NOTCH4, Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways, The Overlap Between Signal Transduction Pathways that Contribute to a Range of LMNA Laminopathies, The influence of laminopathies on Wnt signaling
UniProt: Q5TA89
Entrez ID: 388585
|
Does Knockout of CORO7 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,736
|
Knockout
|
CORO7
|
response to chemicals
|
Colonic Adenocarcinoma Cell Line
|
Gene: CORO7 (coronin 7)
Type: protein-coding
Summary: This gene encodes a member of the coronin protein family. However, unlike other coronin proteins, it is not an actin-binding protein but rather functions as an F-actin regulator directing anterograde Golgi to endosome transport. The encoded protein has two tandem WD-40 domain repeats and localizes to the trans-Golgi network. The protein undergoes K33-linked polyubiquitination via an E3 ligase complex. It is thought to play an essential role in maintenance of Golgi apparatus morphology. Alternative splicing results in multiple transcripts variants; some of which form read-through transcripts with a neighboring gene. [provided by RefSeq, Dec 2016].
Gene Ontology: BP: Golgi organization, Golgi to endosome transport, actin filament organization, actin filament polymerization, cell migration, establishment of cell polarity, positive regulation of hippo signaling, protein transport; MF: actin binding, protein binding; CC: Golgi apparatus, Golgi membrane, cytoplasm, cytoplasmic vesicle, cytosol, membrane, trans-Golgi network
Pathways:
UniProt: P57737
Entrez ID: 79585
|
Does Knockout of PLA2G10 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,340
|
Knockout
|
PLA2G10
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: PLA2G10 (phospholipase A2 group X)
Type: protein-coding
Summary: This gene encodes a member of the phospholipase A2 family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This calcium-dependent enzyme hydrolyzes glycerophospholipids to produce free fatty acids and lysophospholipids. In one example, this enzyme catalyzes the release of arachidonic acid from cell membrane phospholipids, thus playing a role in the production of various inflammatory lipid mediators, such as prostaglandins. The encoded protein may promote the survival of breast cancer cells through its role in lipid metabolism. [provided by RefSeq, Nov 2015].
Gene Ontology: BP: arachidonate metabolic process, arachidonate secretion, axon guidance, cellular response to leukemia inhibitory factor, cholesterol homeostasis, defense response to virus, erythrocyte maturation, fertilization, hair follicle morphogenesis, intestinal stem cell homeostasis, lipid catabolic process, lipid metabolic process, low-density lipoprotein particle remodeling, lysophospholipid transport, macrophage activation, negative regulation of cholesterol efflux, negative regulation of cytokine production involved in inflammatory response, negative regulation of inflammatory response, negative regulation of transcription by RNA polymerase II, nuclear receptor-mediated signaling pathway, phosphatidic acid metabolic process, phosphatidylcholine catabolic process, phosphatidylcholine metabolic process, phosphatidylethanolamine metabolic process, phosphatidylglycerol metabolic process, phosphatidylserine metabolic process, phospholipid metabolic process, platelet activating factor catabolic process, positive regulation of acrosome reaction, positive regulation of arachidonate secretion, positive regulation of lipid storage, positive regulation of macrophage derived foam cell differentiation, positive regulation of prostaglandin secretion, positive regulation of protein metabolic process, production of molecular mediator involved in inflammatory response, prostaglandin biosynthetic process, regulation of macrophage activation, signal transduction involved in regulation of gene expression; MF: 1-alkyl-2-acetylglycerophosphocholine esterase activity, calcium ion binding, calcium-dependent phospholipase A2 activity, hydrolase activity, metal ion binding, phospholipase A2 activity, phospholipase activity, phospholipid binding, protein binding; CC: acrosomal vesicle, cytoplasmic vesicle, extracellular region, extracellular space, lysosome
Pathways: Acyl chain remodelling of PC, Acyl chain remodelling of PE, Acyl chain remodelling of PG, Acyl chain remodelling of PI, Acyl chain remodelling of PS, Arachidonic acid metabolism - Homo sapiens (human), Ether lipid metabolism - Homo sapiens (human), Fat digestion and absorption - Homo sapiens (human), Glycerophospholipid biosynthesis, Glycerophospholipid metabolism - Homo sapiens (human), Linoleic acid metabolism - Homo sapiens (human), Metabolism, Metabolism of lipids, Pancreatic secretion - Homo sapiens (human), Phospholipid metabolism, Ras signaling, Ras signaling pathway - Homo sapiens (human), Synthesis of PA, Vascular smooth muscle contraction - Homo sapiens (human), alpha-Linolenic acid metabolism - Homo sapiens (human), phospholipases
UniProt: O15496
Entrez ID: 8399
|
Does Knockout of DDN in Prostate Cancer Cell Line causally result in cell proliferation?
| 0
| 843
|
Knockout
|
DDN
|
cell proliferation
|
Prostate Cancer Cell Line
|
Gene: DDN (dendrin)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II. Located in cell projection and cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, protein binding; CC: cell projection, cytoplasm, dendrite, dendritic spine membrane, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, nucleus, perikaryon, plasma membrane, postsynapse, postsynaptic membrane, presynapse, synapse
Pathways:
UniProt: O94850
Entrez ID: 23109
|
Does Activation of SH2D6 in Hepatoma Cell Line causally result in response to virus?
| 0
| 1,210
|
Activation
|
SH2D6
|
response to virus
|
Hepatoma Cell Line
|
Gene: SH2D6 (SH2 domain containing 6)
Type: protein-coding
Summary: Predicted to be involved in intracellular signal transduction and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cell surface receptor protein tyrosine kinase signaling pathway, intracellular signal transduction
Pathways:
UniProt: Q7Z4S9
Entrez ID: 284948
|
Does Knockout of SFPQ in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 1,813
|
Knockout
|
SFPQ
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: SFPQ (splicing factor proline and glutamine rich)
Type: protein-coding
Summary: Enables DNA binding activity; histone deacetylase binding activity; and protein homodimerization activity. Involved in several processes, including alternative mRNA splicing, via spliceosome; positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; and regulation of transcription by RNA polymerase II. Acts upstream of or within double-strand break repair via homologous recombination. Located in chromatin; nuclear matrix; and paraspeckles. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, RNA splicing, activation of innate immune response, alternative mRNA splicing, via spliceosome, chromatin remodeling, chromosome organization, dendritic transport of messenger ribonucleoprotein complex, double-strand break repair via homologous recombination, immune system process, innate immune response, mRNA processing, negative regulation of DNA-templated transcription, negative regulation of circadian rhythm, negative regulation of transcription by RNA polymerase II, positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway, positive regulation of sister chromatid cohesion, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of cell cycle, regulation of circadian rhythm, rhythmic process; MF: DNA binding, RNA binding, chromatin binding, histone deacetylase binding, nucleic acid binding, protein binding, protein homodimerization activity, transcription cis-regulatory region binding; CC: RNA polymerase II transcription regulator complex, chromatin, cytoplasm, cytosol, dendrite, nuclear matrix, nuclear speck, nucleoplasm, nucleus, paraspeckles
Pathways: Bacterial Infection Pathways, Disease, EGFR1, Infection with Mycobacterium tuberculosis, Infectious disease, PTK6 Regulates Proteins Involved in RNA Processing, Response of Mtb to phagocytosis, Signal Transduction, Signaling by Non-Receptor Tyrosine Kinases, Signaling by PTK6, Suppression of apoptosis, Type 2 papillary renal cell carcinoma, antisense pathway, mRNA Processing
UniProt: P23246
Entrez ID: 6421
|
Does Knockout of ARIH1 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 1,246
|
Knockout
|
ARIH1
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: ARIH1 (ariadne RBR E3 ubiquitin protein ligase 1)
Type: protein-coding
Summary: Enables enzyme binding activity; ubiquitin-protein transferase activity; and zinc ion binding activity. Involved in protein ubiquitination. Located in Lewy body; cytoplasm; and nuclear body. Colocalizes with cullin-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: PKR/eIFalpha signaling, protein ubiquitination, ubiquitin-dependent protein catabolic process; MF: metal ion binding, protein binding, transferase activity, ubiquitin conjugating enzyme binding, ubiquitin protein ligase activity, ubiquitin protein ligase binding, ubiquitin-like protein transferase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: Cajal body, Cul2-RING ubiquitin ligase complex, Cul3-RING ubiquitin ligase complex, Cul4A-RING E3 ubiquitin ligase complex, Lewy body, SCF ubiquitin ligase complex, cytoplasm, cytosol, nuclear body, nucleoplasm, nucleus, ubiquitin ligase complex
Pathways: Antiviral mechanism by IFN-stimulated genes, Cytokine Signaling in Immune system, Disease, ISG15 antiviral mechanism, Immune System, Infectious disease, Interferon Signaling, Modulation of host responses by IFN-stimulated genes, PKR-mediated signaling, RSV-host interactions, Respiratory Syncytial Virus Infection Pathway, Viral Infection Pathways
UniProt: Q9Y4X5
Entrez ID: 25820
|
Does Knockout of UQCC2 in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 408
|
Knockout
|
UQCC2
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: UQCC2 (ubiquinol-cytochrome c reductase complex assembly factor 2)
Type: protein-coding
Summary: This gene encodes a nucleoid protein localized to the mitochondria inner membrane. The encoded protein affects regulation of insulin secretion, mitochondrial ATP production, and myogenesis through modulation of mitochondrial respiratory chain activity. [provided by RefSeq, Oct 2012].
Gene Ontology: BP: mitochondrial respiratory chain complex III assembly, positive regulation of mitochondrial translation, regulation of insulin secretion, regulation of oxidative phosphorylation, regulation of skeletal muscle cell differentiation; CC: membrane, mitochondrial inner membrane, mitochondrial intermembrane space, mitochondrial matrix, mitochondrial nucleoid, mitochondrion, nuclear body
Pathways: Aerobic respiration and respiratory electron transport, Complex III assembly, Metabolism, Mitochondrial complex III assembly, Respiratory electron transport
UniProt: Q9BRT2
Entrez ID: 84300
|
Does Knockout of SLC39A7 in Cancer Cell Line causally result in cell proliferation?
| 1
| 193
|
Knockout
|
SLC39A7
|
cell proliferation
|
Cancer Cell Line
|
Gene: SLC39A7 (solute carrier family 39 member 7)
Type: protein-coding
Summary: The protein encoded by this gene transports zinc from the Golgi and endoplasmic reticulum to the cytoplasm. This transport may be important for activation of tyrosine kinases, some of which could be involved in cancer progression. Therefore, modulation of the encoded protein could be useful as a therapeutic agent against cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014].
Gene Ontology: BP: B cell differentiation, intracellular zinc ion homeostasis, metal ion transport, monoatomic ion transport, regulation of ferroptosis, skin epidermis development, transmembrane transport, zinc ion transmembrane transport, zinc ion transport; MF: metal ion transmembrane transporter activity, protein binding, zinc ion transmembrane transporter activity; CC: Golgi apparatus, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, nucleoplasm
Pathways: Metal ion SLC transporters, NRF2 pathway, Nuclear Receptors Meta-Pathway, SLC-mediated transmembrane transport, Transport of small molecules, Zinc homeostasis, Zinc influx into cells by the SLC39 gene family, Zinc transporters
UniProt: Q92504
Entrez ID: 7922
|
Does Knockout of DDT in Cancer Cell Line causally result in cell proliferation?
| 0
| 948
|
Knockout
|
DDT
|
cell proliferation
|
Cancer Cell Line
|
Gene: DDT (D-dopachrome tautomerase)
Type: protein-coding
Summary: D-dopachrome tautomerase converts D-dopachrome into 5,6-dihydroxyindole. The DDT gene is related to the migration inhibitory factor (MIF) in terms of sequence, enzyme activity, and gene structure. DDT and MIF are closely linked on chromosome 22. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: melanin biosynthetic process, negative regulation of macrophage chemotaxis, positive regulation of ERK1 and ERK2 cascade, positive regulation of inflammatory response, positive regulation of tumor necrosis factor production; MF: D-dopachrome decarboxylase activity, cytokine receptor binding, dopachrome isomerase activity, lyase activity, phenylpyruvate tautomerase activity; CC: cytoplasm, extracellular exosome, extracellular space
Pathways:
UniProt: P30046
Entrez ID: 1652
|
Does Knockout of TTLL12 in Urinary Bladder Cancer Cell Line causally result in cell proliferation?
| 0
| 180
|
Knockout
|
TTLL12
|
cell proliferation
|
Urinary Bladder Cancer Cell Line
|
Gene: TTLL12 (tubulin tyrosine ligase like 12)
Type: protein-coding
Summary: Enables H4K20me3 modified histone binding activity and tubulin binding activity. Involved in negative regulation of type I interferon-mediated signaling pathway and regulation of mitotic cell cycle. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: chromatin organization, immune system process, innate immune response, negative regulation of type I interferon-mediated signaling pathway, regulation of mitotic cell cycle; MF: ATP binding, histone H4K20 trimethyltransferase activity, histone H4K20me2 reader activity, nucleotide binding, protein binding, tubulin-tyrosine ligase activity; CC: centrosome, cytoplasm, cytoskeleton, cytosol, midbody, nucleus, plasma membrane, spindle
Pathways: Carboxyterminal post-translational modifications of tubulin, Metabolism of proteins, Post-translational protein modification
UniProt: Q14166
Entrez ID: 23170
|
Does Knockout of AKR1C3 in Monocytic Leukemia Cell Line causally result in RNA accumulation?
| 0
| 1,968
|
Knockout
|
AKR1C3
|
RNA accumulation
|
Monocytic Leukemia Cell Line
|
Gene: AKR1C3 (aldo-keto reductase family 1 member C3)
Type: protein-coding
Summary: This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, alcohol metabolic process, cellular response to calcium ion, cellular response to corticosteroid stimulus, cellular response to jasmonic acid stimulus, cellular response to prostaglandin D stimulus, cellular response to prostaglandin stimulus, cellular response to starvation, daunorubicin metabolic process, doxorubicin metabolic process, farnesol catabolic process, hormone metabolic process, keratinocyte differentiation, lipid metabolic process, macromolecule metabolic process, male gonad development, monocarboxylic acid metabolic process, negative regulation of retinoic acid biosynthetic process, positive regulation of cell population proliferation, positive regulation of endothelial cell apoptotic process, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of reactive oxygen species metabolic process, progesterone metabolic process, prostaglandin metabolic process, prostanoid biosynthetic process, regulation of retinoic acid receptor signaling pathway, regulation of testosterone biosynthetic process, renal absorption, response to nutrient, retinal metabolic process, retinoid metabolic process, retinol metabolic process, steroid metabolic process, testosterone biosynthetic process; MF: 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity, 5-alpha-androstane-3-beta,17-beta-diol dehydrogenase (NADP+) activity, Delta4-3-oxosteroid 5beta-reductase activity, alcohol dehydrogenase (NADP+) activity, aldose reductase (NADPH) activity, all-trans-retinol dehydrogenase (NAD+) activity, all-trans-retinol dehydrogenase (NADP+) activity, androstan-3-alpha,17-beta-diol dehydrogenase (NAD+) activity, androsterone dehydrogenase [NAD(P)+] activity, bile acid binding, estradiol 17-beta-dehydrogenase [NAD(P)+] activity, geranylgeranyl reductase activity, ketoreductase activity, ketosteroid monooxygenase activity, oxidoreductase activity, oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor, prostaglandin D2 11-ketoreductase activity, prostaglandin F synthase activity, prostaglandin H2 endoperoxidase reductase activity, protein binding, retinal dehydrogenase (NAD+) activity, testosterone dehydrogenase (NAD+) activity, testosterone dehydrogenase (NADP+) activity; CC: cytoplasm, cytosol, extracellular exosome, nucleus
Pathways: Acetaminophen Action Pathway, Acetylsalicylic Acid Action Pathway, Antipyrine Action Pathway, Antrafenine Action Pathway, Arachidonate metabolism, Arachidonic Acid Metabolism, Arachidonic acid metabolism - Homo sapiens (human), Benzo(a)pyrene metabolism, Bile acid and bile salt metabolism, Bromfenac Action Pathway, Carprofen Action Pathway, Celecoxib Action Pathway, Diclofenac Action Pathway, Diflunisal Action Pathway, Doxorubicin Metabolism Pathway, Etodolac Action Pathway, Etoricoxib Action Pathway, Fatty acid metabolism, Fenoprofen Action Pathway, Flurbiprofen Action Pathway, Folate biosynthesis - Homo sapiens (human), Ibuprofen Action Pathway, Indomethacin Action Pathway, Ketoprofen Action Pathway, Ketorolac Action Pathway, Leukotriene C4 Synthesis Deficiency, Lornoxicam Action Pathway, Lumiracoxib Action Pathway, Magnesium salicylate Action Pathway, Mefenamic Acid Action Pathway, Meloxicam Action Pathway, Metabolism, Metabolism of fat-soluble vitamins, Metabolism of lipids, Metabolism of steroids, Metabolism of vitamins and cofactors, Metapathway biotransformation Phase I and II, Nabumetone Action Pathway, Naproxen Action Pathway, Nepafenac Action Pathway, Ovarian steroidogenesis - Homo sapiens (human), Oxaprozin Action Pathway, Phenylbutazone Action Pathway, Piroxicam Action Pathway, Prostaglandin Synthesis and Regulation, RA biosynthesis pathway, Retinoid metabolism and transport, Rofecoxib Action Pathway, Salicylate-sodium Action Pathway, Salicylic Acid Action Pathway, Salsalate Action Pathway, Sensory Perception, Signal Transduction, Signaling by Nuclear Receptors, Signaling by Retinoic Acid, Steroid hormone biosynthesis - Homo sapiens (human), Sulindac Action Pathway, Suprofen Action Pathway, Synthesis of Prostaglandins (PG) and Thromboxanes (TX), Synthesis of bile acids and bile salts, Synthesis of bile acids and bile salts via 24-hydroxycholesterol, Synthesis of bile acids and bile salts via 27-hydroxycholesterol, Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol, Tenoxicam Action Pathway, Tiaprofenic Acid Action Pathway, Tolmetin Action Pathway, Trisalicylate-choline Action Pathway, Valdecoxib Action Pathway, Visual phototransduction, allopregnanolone biosynthesis, androgen biosynthesis, superpathway of steroid hormone biosynthesis
UniProt: P42330
Entrez ID: 8644
|
Does Knockout of ITM2A in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 0
| 2,114
|
Knockout
|
ITM2A
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: ITM2A (integral membrane protein 2A)
Type: protein-coding
Summary: This gene encodes a type II membrane protein that belongs to the ITM2 family. Studies in mouse suggest that it may be involved in osteo- and chondrogenic differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010].
Gene Ontology: BP: negative regulation of amyloid precursor protein biosynthetic process, plasma cell differentiation; MF: amyloid-beta binding, protein binding; CC: Golgi apparatus, membrane, plasma membrane
Pathways:
UniProt: O43736
Entrez ID: 9452
|
Does Knockout of TUBGCP4 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 149
|
Knockout
|
TUBGCP4
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: TUBGCP4 (tubulin gamma complex component 4)
Type: protein-coding
Summary: This gene encodes a component of the gamma-tubulin ring complex, which is required for microtubule nucleation. In mammalian cells, the protein localizes to centrosomes in association with gamma-tubulin. Crystal structure analysis revealed a structure composed of five helical bundles arranged around conserved hydrophobic cores. An exposed surface area located in the C-terminal domain is essential and sufficient for direct binding to gamma-tubulin. Mutations in this gene that alter microtubule organization are associated with microcephaly and chorioretinopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015].
Gene Ontology: BP: cytoplasmic microtubule organization, meiotic cell cycle, microtubule cytoskeleton organization, microtubule nucleation, mitotic cell cycle, protein-containing complex assembly, spindle assembly; MF: gamma-tubulin binding, microtubule minus-end binding, protein binding, structural constituent of cytoskeleton; CC: centrosome, cytoplasm, cytoskeleton, cytosol, gamma-tubulin complex, gamma-tubulin ring complex, membrane, microtubule, microtubule cytoskeleton, microtubule organizing center, recycling endosome, spindle pole
Pathways: 15q11.2 copy number variation syndrome
UniProt: Q9UGJ1
Entrez ID: 27229
|
Does Knockout of MAGEB10 in Neuroblastoma Cell Line causally result in cell proliferation?
| 0
| 824
|
Knockout
|
MAGEB10
|
cell proliferation
|
Neuroblastoma Cell Line
|
Gene: MAGEB10 (MAGE family member B10)
Type: protein-coding
Summary: This gene encodes a member of the B subfamily of the melanoma associated antigen protein family. The encoded protein is specifically expressed in testis and tumor cells. [provided by RefSeq, Apr 2010].
Gene Ontology:
Pathways:
UniProt: Q96LZ2
Entrez ID: 139422
|
Does Knockout of RPE in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 1,246
|
Knockout
|
RPE
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: RPE (ribulose-5-phosphate-3-epimerase)
Type: protein-coding
Summary: Enables metal ion binding activity; protein homodimerization activity; and ribulose-phosphate 3-epimerase activity. Involved in carbohydrate metabolic process and pentose-phosphate shunt. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: carbohydrate metabolic process, pentose-phosphate shunt, pentose-phosphate shunt, non-oxidative branch; MF: D-ribulose-phosphate 3-epimerase activity, identical protein binding, isomerase activity, metal ion binding, protein binding, protein homodimerization activity, racemase and epimerase activity, acting on carbohydrates and derivatives; CC: cytosol, extracellular exosome
Pathways: Glucose-6-phosphate dehydrogenase deficiency, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Pentose Phosphate Metabolism, Pentose Phosphate Pathway, Pentose and glucuronate interconversions - Homo sapiens (human), Pentose phosphate pathway, Pentose phosphate pathway - Homo sapiens (human), Ribose-5-phosphate isomerase deficiency, Transaldolase deficiency, pentose phosphate pathway, pentose phosphate pathway (non-oxidative branch)
UniProt: Q96AT9
Entrez ID: 6120
|
Does Knockout of RIPPLY2 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,352
|
Knockout
|
RIPPLY2
|
response to chemicals
|
Cervical Adenocarcinoma Cell Line
|
Gene: RIPPLY2 (ripply transcriptional repressor 2)
Type: protein-coding
Summary: This gene encodes a nuclear protein that belongs to a novel family of proteins required for vertebrate somitogenesis. Members of this family have a tetrapeptide WRPW motif that is required for interaction with the transcriptional repressor Groucho and a carboxy-terminal Ripply homology domain/Bowline-DSCR-Ledgerline conserved region required for transcriptional repression. Null mutant mice die soon after birth and display defects in axial skeleton segmentation due to defective somitogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016].
Gene Ontology: BP: Notch signaling pathway, axis specification, bone morphogenesis, determination of left/right symmetry, embryonic pattern specification, negative regulation of transcription by RNA polymerase II, ossification, post-anal tail morphogenesis, regulation of gene expression, somite rostral/caudal axis specification, somitogenesis; CC: nucleus
Pathways: Developmental Biology, Formation of paraxial mesoderm, Gastrulation, Gene regulatory network modelling somitogenesis, Somitogenesis, Somitogenesis in the context of spondylocostal dysostosis
UniProt: Q5TAB7
Entrez ID: 134701
|
Does Knockout of LRTOMT in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 427
|
Knockout
|
LRTOMT
|
cell proliferation
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: LRTOMT (leucine rich transmembrane and O-methyltransferase domain containing)
Type: protein-coding
Summary: This locus represents naturally occurring readthrough transcription between the neighboring LRRC51 (leucine-rich repeat containing 51) and TOMT (transmembrane O-methyltransferase) genes on chromosome 11. The readthrough transcript encodes a fusion protein that shares sequence identity with each individual gene product. Multiple reports implicate mutations in this gene in nonsyndromic deafness.[provided by RefSeq, Feb 2021].
Gene Ontology:
Pathways: Dopamine clearance from the synaptic cleft, Dopaminergic synapse - Homo sapiens (human), Enzymatic degradation of dopamine by COMT, Neuronal System, Neurotransmitter clearance, Steroid hormone biosynthesis - Homo sapiens (human), Transmission across Chemical Synapses, Tyrosine metabolism - Homo sapiens (human), noradrenaline and adrenaline degradation
UniProt: Q8WZ04
Entrez ID: 220074
|
Does Knockout of LONP1 in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 1,311
|
Knockout
|
LONP1
|
cell proliferation
|
Oral Squamous Cell Carcinoma Cell Line
|
Gene: LONP1 (lon peptidase 1, mitochondrial)
Type: protein-coding
Summary: This gene encodes a mitochondrial matrix protein that belongs to the Lon family of ATP-dependent proteases. This protein mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides in the mitochondrial matrix. It may also have a chaperone function in the assembly of inner membrane protein complexes, and participate in the regulation of mitochondrial gene expression and maintenance of the integrity of the mitochondrial genome. Decreased expression of this gene has been noted in a patient with hereditary spastic paraplegia (PMID:18378094). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2013].
Gene Ontology: BP: cellular response to oxidative stress, chaperone-mediated protein complex assembly, mitochondrial DNA metabolic process, mitochondrial protein catabolic process, mitochondrion organization, negative regulation of insulin receptor signaling pathway, oxidation-dependent protein catabolic process, protein catabolic process, protein quality control for misfolded or incompletely synthesized proteins, protein-containing complex assembly, proteolysis, proteolysis involved in protein catabolic process, response to aluminum ion, response to hormone, response to hypoxia; MF: ADP binding, ATP binding, ATP hydrolysis activity, ATP-dependent peptidase activity, DNA binding, DNA polymerase binding, G-quadruplex DNA binding, PH domain binding, hydrolase activity, identical protein binding, insulin receptor substrate binding, mitochondrial promoter sequence-specific DNA binding, nucleotide binding, peptidase activity, protein binding, sequence-specific DNA binding, serine-type endopeptidase activity, serine-type peptidase activity, single-stranded DNA binding, single-stranded RNA binding; CC: cytosol, membrane, mitochondrial matrix, mitochondrial nucleoid, mitochondrion, nucleoplasm
Pathways: Cellular responses to stimuli, Cellular responses to stress, Metabolism of proteins, Mitochondrial protein degradation, Mitochondrial unfolded protein response (UPRmt)
UniProt: P36776
Entrez ID: 9361
|
Does Knockout of COG3 in Multiple Myeloma Cell Line causally result in cell proliferation?
| 1
| 816
|
Knockout
|
COG3
|
cell proliferation
|
Multiple Myeloma Cell Line
|
Gene: COG3 (component of oligomeric golgi complex 3)
Type: protein-coding
Summary: This gene encodes a component of the conserved oligomeric Golgi (COG) complex which is composed of eight different subunits and is required for normal Golgi morphology and localization. Defects in the COG complex result in multiple deficiencies in protein glycosylation. The protein encoded by this gene is involved in ER-Golgi transport.[provided by RefSeq, Jun 2011].
Gene Ontology: BP: Golgi organization, endoplasmic reticulum to Golgi vesicle-mediated transport, glycosylation, intra-Golgi vesicle-mediated transport, intracellular protein transport, protein glycosylation, protein localization to organelle, protein stabilization, protein transport, retrograde transport, vesicle recycling within Golgi, retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; CC: Golgi apparatus, Golgi cisterna membrane, Golgi membrane, Golgi transport complex, cis-Golgi network, cytosol, membrane, plasma membrane, trans-Golgi network membrane
Pathways: Asparagine N-linked glycosylation, COPI-mediated anterograde transport, ER to Golgi Anterograde Transport, Intra-Golgi and retrograde Golgi-to-ER traffic, Intra-Golgi traffic, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, Retrograde transport at the Trans-Golgi-Network, Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: Q96JB2
Entrez ID: 83548
|
Does Knockout of SOX13 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,339
|
Knockout
|
SOX13
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: SOX13 (SRY-box transcription factor 13)
Type: protein-coding
Summary: This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. It has also been determined to be a type-1 diabetes autoantigen, also known as islet cell antibody 12. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: anatomical structure morphogenesis, cell differentiation, cell fate commitment, gamma-delta T cell differentiation, negative regulation of DNA-templated transcription, negative regulation of canonical Wnt signaling pathway, negative regulation of transcription by RNA polymerase II, positive regulation of brown fat cell differentiation, positive regulation of gamma-delta T cell differentiation, regulation of DNA-templated transcription, regulation of gamma-delta T cell differentiation, regulation of transcription by RNA polymerase II, spinal cord oligodendrocyte cell differentiation; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, identical protein binding, protein binding, sequence-specific DNA binding, transcription cis-regulatory region binding; CC: chromatin, cytoplasm, nucleoplasm, nucleus
Pathways: Deactivation of the beta-catenin transactivating complex, Signal Transduction, Signaling by WNT, TCF dependent signaling in response to WNT
UniProt: Q9UN79
Entrez ID: 9580
|
Does Knockout of SERF2 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 865
|
Knockout
|
SERF2
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: SERF2 (small EDRK-rich factor 2)
Type: protein-coding
Summary: Involved in protein destabilization. Predicted to be located in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: cytosol, nucleus
Pathways:
UniProt: P84101
Entrez ID: 10169
|
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