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string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Activation of DYRK1A in T cell causally result in protein/peptide accumulation?
| 0
| 2,425
|
Activation
|
DYRK1A
|
protein/peptide accumulation
|
T cell
|
Gene: DYRK1A (dual specificity tyrosine phosphorylation regulated kinase 1A)
Type: protein-coding
Summary: This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: chromatin remodeling, circadian rhythm, double-strand break repair via homologous recombination, double-strand break repair via nonhomologous end joining, negative regulation of DNA damage response, signal transduction by p53 class mediator, negative regulation of heterochromatin formation, negative regulation of mRNA splicing, via spliceosome, negative regulation of microtubule polymerization, nervous system development, peptidyl-tyrosine phosphorylation, positive regulation of DNA-templated transcription, positive regulation of RNA splicing, protein autophosphorylation, protein phosphorylation, regulation of alternative mRNA splicing, via spliceosome, regulation of amyloid-beta formation, regulation of neurofibrillary tangle assembly, regulation of transcription by RNA polymerase II; MF: ATP binding, RNA polymerase II CTD heptapeptide repeat kinase activity, actin binding, cytoskeletal protein binding, histone H3T45 kinase activity, identical protein binding, kinase activity, non-membrane spanning protein tyrosine kinase activity, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, protein serine/threonine/tyrosine kinase activity, protein tyrosine kinase activity, splicing factor binding, tau protein binding, tau-protein kinase activity, transcription coactivator activity, transferase activity, tubulin binding; CC: actin filament, axon, centrosome, cytoplasm, cytoskeleton, cytosol, dendrite, microtubule, neurofilament, nuclear speck, nucleoplasm, nucleus, ribonucleoprotein complex
Pathways: EGFR1, Hedgehog, T-Cell Receptor and Co-stimulatory Signaling, TCR
UniProt: Q13627
Entrez ID: 1859
|
Does Knockout of PRAMEF6 in T-lymphoma cell line causally result in cell proliferation?
| 1
| 478
|
Knockout
|
PRAMEF6
|
cell proliferation
|
T-lymphoma cell line
|
Gene: PRAMEF6 (PRAME family member 6)
Type: protein-coding
Summary: Enables ubiquitin ligase-substrate adaptor activity. Involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Part of Cul2-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: negative regulation of DNA-templated transcription, negative regulation of apoptotic process, negative regulation of cell differentiation, positive regulation of cell population proliferation, proteasome-mediated ubiquitin-dependent protein catabolic process, protein ubiquitination; MF: ubiquitin-like ligase-substrate adaptor activity; CC: Cul2-RING ubiquitin ligase complex, cytoplasm
Pathways:
UniProt: Q5VXH4
Entrez ID: 440561
|
Does Knockout of ABCB5 in Colorectal Cancer Cell Line causally result in cell proliferation?
| 0
| 783
|
Knockout
|
ABCB5
|
cell proliferation
|
Colorectal Cancer Cell Line
|
Gene: ABCB5 (ATP binding cassette subfamily B member 5)
Type: protein-coding
Summary: ABCB5 belongs to the ATP-binding cassette (ABC) transporter superfamily of integral membrane proteins. These proteins participate in ATP-dependent transmembrane transport of structurally diverse molecules ranging from small ions, sugars, and peptides to more complex organic molecules (Chen et al., 2005 [PubMed 15760339]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: cell differentiation, eye development, regulation of membrane potential, transmembrane transport, xenobiotic transport; MF: ABC-type transporter activity, ABC-type xenobiotic transporter activity, ATP binding, ATP hydrolysis activity, ATPase-coupled transmembrane transporter activity, efflux transmembrane transporter activity, nucleotide binding; CC: apical plasma membrane, membrane, plasma membrane
Pathways: ABC transporters - Homo sapiens (human), ABC-family proteins mediated transport, Transport of small molecules
UniProt: Q2M3G0
Entrez ID: 340273
|
Does Knockout of PAX3 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,789
|
Knockout
|
PAX3
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: PAX3 (paired box 3)
Type: protein-coding
Summary: This gene is a member of the paired box (PAX) family of transcription factors. Members of the PAX family typically contain a paired box domain and a paired-type homeodomain. These genes play critical roles during fetal development. Mutations in paired box gene 3 are associated with Waardenburg syndrome, craniofacial-deafness-hand syndrome, and alveolar rhabdomyosarcoma. The translocation t(2;13)(q35;q14), which represents a fusion between PAX3 and the forkhead gene, is a frequent finding in alveolar rhabdomyosarcoma. Alternative splicing results in transcripts encoding isoforms with different C-termini. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: anatomical structure morphogenesis, animal organ morphogenesis, apoptotic process, muscle organ development, nervous system development, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, sensory perception of sound; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: chromatin, nucleoplasm, nucleus
Pathways: 22q11.2 copy number variation syndrome, Chromatin modifying enzymes, Chromatin organization, Developmental Biology, Ectoderm Differentiation, Gastrulation, HATs acetylate histones, MITF-M-regulated melanocyte development, Neural Crest Differentiation, Regulation of retinoblastoma protein, Specification of the neural plate border, Transcriptional and post-translational regulation of MITF-M expression and activity, Transcriptional misregulation in cancer - Homo sapiens (human)
UniProt: P23760
Entrez ID: 5077
|
Does Knockout of ACTG1 in Cancer Cell Line causally result in cell proliferation?
| 1
| 948
|
Knockout
|
ACTG1
|
cell proliferation
|
Cancer Cell Line
|
Gene: ACTG1 (actin gamma 1)
Type: protein-coding
Summary: Actins are highly conserved proteins that are involved in various types of cell motility and in maintenance of the cytoskeleton. Three main groups of actin isoforms have been identified in vertebrate animals: alpha, beta, and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton and as mediators of internal cell motility. Actin gamma 1, encoded by this gene, is a cytoplasmic actin found in all cell types. Mutations in this gene are associated with DFNA20/26, a subtype of autosomal dominant non-syndromic sensorineural progressive hearing loss and also with Baraitser-Winter syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2017].
Gene Ontology: BP: angiogenesis, axonogenesis, cell motility, cellular response to type II interferon, maintenance of blood-brain barrier, morphogenesis of a polarized epithelium, platelet aggregation, positive regulation of cell migration, positive regulation of gene expression, positive regulation of wound healing, postsynaptic actin cytoskeleton organization, protein localization to bicellular tight junction, regulation of focal adhesion assembly, regulation of stress fiber assembly, regulation of synaptic vesicle endocytosis, regulation of transepithelial transport, sarcomere organization, tight junction assembly; MF: ATP binding, hydrolase activity, identical protein binding, nucleotide binding, profilin binding, protein binding, protein kinase binding, structural constituent of cytoskeleton, structural constituent of postsynaptic actin cytoskeleton, ubiquitin protein ligase binding; CC: NuA4 histone acetyltransferase complex, Schaffer collateral - CA1 synapse, actin cytoskeleton, actin filament, apical junction complex, apical part of cell, axon, basal body patch, blood microparticle, calyx of Held, cell-cell junction, cytoplasm, cytoskeleton, cytosol, dense body, extracellular exosome, extracellular space, filamentous actin, focal adhesion, membrane, myofibril, nucleus, phagocytic vesicle, plasma membrane, synapse
Pathways: Adherens junction - Homo sapiens (human), Adherens junctions interactions, Amyotrophic lateral sclerosis - Homo sapiens (human), Apoptosis - Homo sapiens (human), Arrhythmogenic Right Ventricular Cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy - Homo sapiens (human), Axon guidance, Bacterial invasion of epithelial cells - Homo sapiens (human), Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cell-extracellular matrix interactions, Clathrin-mediated endocytosis, Common Pathways Underlying Drug Addiction, Developmental Biology, Dilated cardiomyopathy - Homo sapiens (human), Disease, Diseases of signal transduction by growth factor receptors and second messengers, EPH-Ephrin signaling, EPH-ephrin mediated repulsion of cells, EPHB-mediated forward signaling, Ebola Virus Pathway on Host, Extracellular matrix organization, FCGR3A-mediated phagocytosis, Fas ligand pathway and stress induction of heat shock proteins, Fcgamma receptor (FCGR) dependent phagocytosis, Fluid shear stress and atherosclerosis - Homo sapiens (human), Focal Adhesion, Focal adhesion - Homo sapiens (human), Formation of annular gap junctions, Formation of the dystrophin-glycoprotein complex (DGC), Gap junction degradation, Gap junction trafficking, Gap junction trafficking and regulation, Gastric acid secretion - Homo sapiens (human), Hepatocellular carcinoma - Homo sapiens (human), Hippo signaling pathway - Homo sapiens (human), Hypertrophic cardiomyopathy - Homo sapiens (human), Immune System, Infectious disease, Influenza A - Homo sapiens (human), Innate Immune System, Interaction between L1 and Ankyrins, L1CAM interactions, Leishmania infection, Leishmania phagocytosis, Leukocyte transendothelial migration - Homo sapiens (human), MAP2K and MAPK activation, MAPK family signaling cascades, MAPK1/MAPK3 signaling, Mechanoregulation and pathology of YAP-TAZ via Hippo and non-Hippo mechanisms, Membrane Trafficking, Myometrial relaxation and contraction pathways, Nervous system development, Neutrophil extracellular trap formation - Homo sapiens (human), Non-integrin membrane-ECM interactions, Oncogenic MAPK signaling, Oxytocin signaling pathway - Homo sapiens (human), Paradoxical activation of RAF signaling by kinase inactive BRAF, Parasite infection, Parasitic Infection Pathways, Pathogenic Escherichia coli infection, Pathogenic Escherichia coli infection - Homo sapiens (human), Phagosome - Homo sapiens (human), Platelet activation - Homo sapiens (human), Proteoglycans in cancer - Homo sapiens (human), RAF/MAP kinase cascade, RHO GTPase Effectors, RHO GTPase cycle, RHO GTPases Activate Formins, RHO GTPases Activate WASPs and WAVEs, RHO GTPases activate IQGAPs, RHOBTB GTPase Cycle, RHOBTB2 GTPase cycle, Rap1 signaling pathway - Homo sapiens (human), Recycling pathway of L1, Regulation of Actin Cytoskeleton, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of actin cytoskeleton - Homo sapiens (human), Regulation of actin dynamics for phagocytic cup formation, Salmonella infection - Homo sapiens (human), Sensory Perception, Sensory processing of sound, Sensory processing of sound by inner hair cells of the cochlea, Sensory processing of sound by outer hair cells of the cochlea, Shigellosis - Homo sapiens (human), Signal Transduction, Signaling by BRAF and RAF1 fusions, Signaling by RAF1 mutants, Signaling by RAS mutants, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by VEGF, Signaling by high-kinase activity BRAF mutants, Signaling by moderate kinase activity BRAF mutants, Signaling downstream of RAS mutants, Striated Muscle Contraction Pathway, Thermogenesis, Thermogenesis - Homo sapiens (human), Thyroid hormone signaling pathway - Homo sapiens (human), Tight junction - Homo sapiens (human), Translocation of SLC2A4 (GLUT4) to the plasma membrane, VEGFA-VEGFR2 Pathway, VEGFA-VEGFR2 Signaling Pathway, Vesicle-mediated transport, Vibrio cholerae infection - Homo sapiens (human), Viral myocarditis - Homo sapiens (human), Yersinia infection - Homo sapiens (human)
UniProt: P63261
Entrez ID: 71
|
Does Knockout of TRNAU1AP in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 287
|
Knockout
|
TRNAU1AP
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: TRNAU1AP (tRNA selenocysteine 1 associated protein 1)
Type: protein-coding
Summary: Enables RNA binding activity. Predicted to be involved in selenocysteine incorporation. Predicted to be located in cytoplasm. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: selenocysteine incorporation, translation; MF: RNA binding, nucleic acid binding, protein binding, tRNA binding; CC: cytoplasm, nucleus
Pathways:
UniProt: Q9NX07
Entrez ID: 54952
|
Does Knockout of LYRM9 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 951
|
Knockout
|
LYRM9
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: LYRM9 (LYR motif containing 9)
Type: protein-coding
Summary: Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology:
Pathways:
UniProt: A8MSI8
Entrez ID: 201229
|
Does Knockout of PAK1IP1 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 69
|
Knockout
|
PAK1IP1
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: PAK1IP1 (PAK1 interacting protein 1)
Type: protein-coding
Summary: Involved in regulation of signal transduction by p53 class mediator and ribosomal large subunit biogenesis. Located in nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cell population proliferation, maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), negative regulation of signal transduction, regulation of signal transduction by p53 class mediator, ribosomal large subunit biogenesis, ribosome biogenesis, roof of mouth development; MF: protein binding, protein kinase inhibitor activity; CC: nucleolus, nucleus
Pathways:
UniProt: Q9NWT1
Entrez ID: 55003
|
Does Knockout of LARP1 in Ovarian Cancer Cell Line causally result in cell proliferation?
| 0
| 699
|
Knockout
|
LARP1
|
cell proliferation
|
Ovarian Cancer Cell Line
|
Gene: LARP1 (La ribonucleoprotein 1, translational regulator)
Type: protein-coding
Summary: Enables eukaryotic initiation factor 4E binding activity; nucleic acid binding activity; and ribosomal small subunit binding activity. Involved in several processes, including TORC1 signaling; cellular response to rapamycin; and posttranscriptional regulation of gene expression. Located in cytoplasmic stress granule. Colocalizes with TORC1 complex and polysomal ribosome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: TOR signaling, TORC1 signaling, cell population proliferation, cellular response to rapamycin, mRNA stabilization, negative regulation of translation, negative regulation of translational initiation, positive regulation of macroautophagy, positive regulation of translation, positive regulation of translational initiation, positive regulation of viral genome replication, post-transcriptional regulation of gene expression, regulation of translation, response to amino acid starvation, translation, translational initiation; MF: RNA 7-methylguanosine cap binding, RNA binding, RNA cap binding, cadherin binding, eukaryotic initiation factor 4E binding, mRNA 3'-UTR binding, mRNA 5'-UTR binding, protein binding, ribosomal small subunit binding, translation activator activity, translation initiation factor binding; CC: TORC1 complex, cytoplasm, cytoplasmic stress granule, cytosol, membrane
Pathways: Disease, Infectious disease, SARS-CoV Infections, SARS-CoV-2 Infection, SARS-CoV-2 activates/modulates innate and adaptive immune responses, SARS-CoV-2 innate immunity evasion and cell-specific immune response, SARS-CoV-2-host interactions, Viral Infection Pathways
UniProt: Q6PKG0
Entrez ID: 23367
|
Does Knockout of MAP4K2 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 0
| 758
|
Knockout
|
MAP4K2
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: MAP4K2 (mitogen-activated protein kinase kinase kinase kinase 2)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015].
Gene Ontology: BP: JNK cascade, immune response, immune system process, innate immune response, intracellular signal transduction, positive regulation of JNK cascade, positive regulation of JUN kinase activity, protein phosphorylation, vesicle targeting; MF: ATP binding, MAP kinase kinase kinase kinase activity, kinase activity, mitogen-activated protein kinase kinase kinase binding, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: Golgi apparatus, Golgi membrane, basolateral plasma membrane, cytoplasm, membrane, plasma membrane
Pathways: Angiopoietin Like Protein 8 Regulatory Pathway, Hippo-Yap signaling pathway, Insulin Signaling, MAPK Signaling Pathway, MAPK signaling pathway - Homo sapiens (human), Mechanoregulation and pathology of YAP-TAZ via Hippo and non-Hippo mechanisms, TNF receptor signaling pathway , TNF-alpha signaling pathway, TNFalpha, role of mal in rho-mediated activation of srf, tnf/stress related signaling
UniProt: Q12851
Entrez ID: 5871
|
Does Knockout of PSMD3 in Ewing's Sarcoma Cell Line causally result in cell proliferation?
| 1
| 763
|
Knockout
|
PSMD3
|
cell proliferation
|
Ewing's Sarcoma Cell Line
|
Gene: PSMD3 (proteasome 26S subunit, non-ATPase 3)
Type: protein-coding
Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the proteasome subunit S3 family that functions as one of the non-ATPase subunits of the 19S regulator lid. Single nucleotide polymorphisms in this gene are associated with neutrophil count. [provided by RefSeq, Jul 2012].
Gene Ontology: BP: proteasome-mediated ubiquitin-dependent protein catabolic process, regulation of protein catabolic process, ubiquitin-dependent protein catabolic process; MF: enzyme regulator activity, protein binding; CC: cytosol, extracellular exosome, extracellular region, ficolin-1-rich granule lumen, membrane, nucleoplasm, nucleus, proteasome accessory complex, proteasome complex, proteasome regulatory particle, proteasome regulatory particle, lid subcomplex, secretory granule lumen
Pathways: ABC transporter disorders, ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, AUF1 (hnRNP D0) binds and destabilizes mRNA, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Activation of NF-kappaB in B cells, Adaptive Immune System, Adherens junctions interactions, Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Antigen processing-Cross presentation, Antigen processing: Ubiquitination & Proteasome degradation, Apoptosis, Assembly of the pre-replicative complex, Asymmetric localization of PCP proteins, Autodegradation of Cdh1 by Cdh1:APC/C, Autodegradation of the E3 ubiquitin ligase COP1, Axon guidance, Beta-catenin independent WNT signaling, C-type lectin receptors (CLRs), CDK-mediated phosphorylation and removal of Cdc6, CLEC7A (Dectin-1) signaling, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cellular response to chemical stress, Cellular response to hypoxia, Cellular responses to stimuli, Cellular responses to stress, Circadian clock, Class I MHC mediated antigen processing & presentation, Co-inhibition by PD-1, Cross-presentation of soluble exogenous antigens (endosomes), Cyclin A:Cdk2-associated events at S phase entry, Cyclin E associated events during G1/S transition , Cytokine Signaling in Immune system, DNA Replication, DNA Replication Pre-Initiation, Dectin-1 mediated noncanonical NF-kB signaling, Defective CFTR causes cystic fibrosis, Degradation of AXIN, Degradation of CDH1, Degradation of CRY and PER proteins, Degradation of DVL, Degradation of GLI1 by the proteasome, Degradation of GLI2 by the proteasome, Degradation of beta-catenin by the destruction complex, Deubiquitination, Developmental Biology, Disease, Diseases of signal transduction by growth factor receptors and second messengers, Disorders of transmembrane transporters, Downstream TCR signaling, Downstream signaling events of B Cell Receptor (BCR), ER-Phagosome pathway, Epstein-Barr virus infection - Homo sapiens (human), FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, FCERI mediated NF-kB activation, Fc epsilon receptor (FCERI) signaling, Formation of paraxial mesoderm, G1/S DNA Damage Checkpoints, G1/S Transition, G2/M Checkpoints, G2/M Transition, GLI3 is processed to GLI3R by the proteasome, GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2, GSK3B-mediated proteasomal degradation of PD-L1(CD274), Gastrulation, Gene expression (Transcription), Generic Transcription Pathway, HIV Infection, Hedgehog 'off' state, Hedgehog 'on' state, Hedgehog ligand biogenesis, Hh mutants abrogate ligand secretion, Hh mutants are degraded by ERAD, Host Interactions of HIV factors, Huntington disease - Homo sapiens (human), Immune System, Infectious disease, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, Intracellular signaling by second messengers, KEAP1-NFE2L2 pathway, M Phase, MAPK family signaling cascades, MAPK1/MAPK3 signaling, MAPK6/MAPK4 signaling, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of polyamines, Metabolism of proteins, Mitotic Anaphase, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, NIK-->noncanonical NF-kB signaling, Neddylation, Negative regulation of NOTCH4 signaling, Nervous system development, Neutrophil degranulation, Nuclear events mediated by NFE2L2, Orc1 removal from chromatin, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, PCP/CE pathway, PIP3 activates AKT signaling, PTEN Regulation, Parkin-Ubiquitin Proteasomal System pathway, Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Post-translational protein modification, Prion disease - Homo sapiens (human), Programmed Cell Death, Proteasome - Homo sapiens (human), Proteasome Degradation, Proteasome assembly, RAF/MAP kinase cascade, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Regulation of APC/C activators between G1/S and early anaphase, Regulation of Apoptosis, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of PTEN stability and activity, Regulation of RAS by GAPs, Regulation of RUNX2 expression and activity, Regulation of RUNX3 expression and activity, Regulation of T cell activation by CD28 family, Regulation of activated PAK-2p34 by proteasome mediated degradation, Regulation of expression of SLITs and ROBOs, Regulation of mRNA stability by proteins that bind AU-rich elements, Regulation of mitotic cell cycle, Regulation of ornithine decarboxylase (ODC), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, S Phase, SCF(Skp2)-mediated degradation of p27/p21, SCF-beta-TrCP mediated degradation of Emi1, SPOP-mediated proteasomal degradation of PD-L1(CD274), Separation of Sister Chromatids, Signal Transduction, Signaling by Hedgehog, Signaling by Interleukins, Signaling by NOTCH, Signaling by NOTCH4, Signaling by ROBO receptors, Signaling by WNT, Signaling by the B Cell Receptor (BCR), Somitogenesis, Spinocerebellar ataxia - Homo sapiens (human), Stabilization of p53, Switching of origins to a post-replicative state, Synthesis of DNA, TCF dependent signaling in response to WNT, TCR signaling, TNFR2 non-canonical NF-kB pathway, TNFalpha, The role of GTSE1 in G2/M progression after G2 checkpoint, Transcriptional regulation by RUNX1, Transcriptional regulation by RUNX2, Transcriptional regulation by RUNX3, Translation, Transport of small molecules, UCH proteinases, Ub-specific processing proteases, Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, Ubiquitin-dependent degradation of Cyclin D, Vif-mediated degradation of APOBEC3G, Viral Infection Pathways, Vpu mediated degradation of CD4, p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint, p53-Independent G1/S DNA Damage Checkpoint, proteasome complex
UniProt: O43242
Entrez ID: 5709
|
Does Knockout of RBL2 in Medulloblastoma Cell Line causally result in cell proliferation?
| 0
| 408
|
Knockout
|
RBL2
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: RBL2 (RB transcriptional corepressor like 2)
Type: protein-coding
Summary: Enables promoter-specific chromatin binding activity. Involved in regulation of lipid kinase activity. Acts upstream of or within negative regulation of gene expression. Located in chromosome; cytosol; and nuclear lumen. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cell differentiation, chromatin organization, negative regulation of G1/S transition of mitotic cell cycle, negative regulation of gene expression, regulation of cell cycle, regulation of lipid kinase activity, regulation of transcription by RNA polymerase II; MF: DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, promoter-specific chromatin binding, protein binding; CC: chromatin, chromosome, cytosol, extracellular exosome, nucleolus, nucleoplasm, nucleus, transcription regulator complex
Pathways: Adipogenesis, Cell Cycle, Cell Cycle, Mitotic, Cell cycle, Cell cycle - Homo sapiens (human), Cellular senescence - Homo sapiens (human), Cyclin A:Cdk2-associated events at S phase entry, Cyclin D associated events in G1, Cyclin E associated events during G1/S transition , DNA damage response (only ATM dependent), E2F transcription factor network, FOXO-mediated transcription, FOXO-mediated transcription of cell cycle genes, FoxO family signaling, FoxO signaling pathway - Homo sapiens (human), G0 and Early G1, G1 Phase, G1/S Transition, G1/S-Specific Transcription, Gene expression (Transcription), Generic Transcription Pathway, Human papillomavirus infection - Homo sapiens (human), ID, ID signaling pathway, Mitotic G1 phase and G1/S transition, Monoamine Transport, PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), RNA Polymerase II Transcription, S Phase, TGF-beta Signaling Pathway, TGF_beta_Receptor, TP53 Regulates Transcription of Cell Cycle Genes, TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest, Thyroid stimulating hormone (TSH) signaling pathway, Transcription of E2F targets under negative control by DREAM complex, Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1, Transcriptional Regulation by TP53, Viral carcinogenesis - Homo sapiens (human), mets affect on macrophage differentiation
UniProt: Q08999
Entrez ID: 5934
|
Does Knockout of MAFK in Renal Cancer Cell Line causally result in cell proliferation?
| 0
| 319
|
Knockout
|
MAFK
|
cell proliferation
|
Renal Cancer Cell Line
|
Gene: MAFK (MAF bZIP transcription factor K)
Type: protein-coding
Summary: The developmentally regulated expression of the globin genes depends on upstream regulatory elements termed locus control regions (LCRs). LCRs are associated with powerful enhancer activity that is mediated by the transcription factor NFE2 (nuclear factor erythroid-2). NFE2 recognition sites are also present in the gene promoters of 2 heme biosynthetic enzymes, porphobilinogen deaminase (PBGD; MIM 609806) and ferrochelatase (FECH; MIM 612386). NFE2 DNA-binding activity consists of a heterodimer containing an 18-kD Maf protein (MafF, MafG (MIM 602020), or MafK) and p45 (MIM 601490). Both subunits are members of the activator protein-1 superfamily of basic leucine zipper (bZIP) proteins (see MIM 165160). Maf homodimers suppress transcription at NFE2 sites.[supplied by OMIM, Nov 2008].
Gene Ontology: BP: negative regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, protein binding, sequence-specific DNA binding, transcription cis-regulatory region binding; CC: RNA polymerase II transcription regulator complex, chromatin, nucleoplasm, nucleus
Pathways: Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Cytoprotection by HMOX1, Ethanol metabolism resulting in production of ROS by CYP2E1, Factors involved in megakaryocyte development and platelet production, Heme signaling, Hemostasis, KEAP1-NFE2L2 pathway, NFE2L2 regulating ER-stress associated genes, NFE2L2 regulating MDR associated enzymes, NFE2L2 regulating anti-oxidant/detoxification enzymes, NFE2L2 regulating inflammation associated genes, NFE2L2 regulating tumorigenic genes, Nuclear events mediated by NFE2L2, Regulation of BACH1 activity, Regulation of HMOX1 expression and activity, Regulation of NFE2L2 gene expression, oxidative stress induced gene expression via nrf2
UniProt: O60675
Entrez ID: 7975
|
Does Knockout of UNC80 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,352
|
Knockout
|
UNC80
|
response to chemicals
|
Cervical Adenocarcinoma Cell Line
|
Gene: UNC80 (unc-80 subunit of NALCN channel complex)
Type: protein-coding
Summary: The protein encoded by this gene is a component of a voltage-independent 'leak' ion-channel complex, in which it performs essential functions, such as serving as a bridge between two other components (sodium leak channel non-selective and UNC79) and as a scaffold for Src kinases. Leak channels play an importnat role in establishment and maintenance of resting membrane potentials in neurons. Mutations in this gene are associated with congenital infantile encephalopathy, intellectual disability and growth issues. [provided by RefSeq, Aug 2016].
Gene Ontology: BP: monoatomic cation homeostasis, monoatomic cation transmembrane transport; CC: axon, cation channel complex, membrane, plasma membrane
Pathways: Ion channel transport, Stimuli-sensing channels, Transport of small molecules
UniProt: Q8N2C7
Entrez ID: 285175
|
Does Knockout of KCNIP2 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 149
|
Knockout
|
KCNIP2
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: KCNIP2 (potassium voltage-gated channel interacting protein 2)
Type: protein-coding
Summary: This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belongs to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified from this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: action potential, chemical synaptic transmission, clustering of voltage-gated potassium channels, detection of calcium ion, membrane repolarization, membrane repolarization during cardiac muscle cell action potential, monoatomic ion transmembrane transport, monoatomic ion transport, muscle contraction, positive regulation of potassium ion export across plasma membrane, potassium ion transmembrane transport, potassium ion transport, regulation of heart contraction, regulation of membrane repolarization, regulation of potassium ion export across plasma membrane, regulation of potassium ion transmembrane transport, regulation of signal transduction, signal transduction; MF: A-type (transient outward) potassium channel activity, ER retention sequence binding, calcium ion binding, identical protein binding, metal ion binding, potassium channel activity, potassium channel regulator activity, protein binding, protein-containing complex binding, transmembrane transporter binding; CC: Kv4.2-KChIP2 channel complex, cytoplasm, dendrite, membrane, monoatomic ion channel complex, plasma membrane, synapse, voltage-gated potassium channel complex
Pathways: 3-Methylthiofentanyl Action Pathway, Acebutolol Action Pathway, Alfentanil Action Pathway, Alprenolol Action Pathway, Alvimopan Action Pathway, Amiodarone Action Pathway, Amlodipine Action Pathway, Anileridine Action Pathway, Arbutamine Action Pathway, Atenolol Action Pathway, Benzocaine Action Pathway, Betaxolol Action Pathway, Bevantolol Action Pathway, Bisoprolol Action Pathway, Bopindolol Action Pathway, Bupivacaine Action Pathway, Bupranolol Action Pathway, Buprenorphine Action Pathway, Cardiac conduction, Carfentanil Action Pathway, Carteolol Action Pathway, Carvedilol Action Pathway, Chloroprocaine Action Pathway, Citalopram Action Pathway, Cocaine Action Pathway, Codeine Action Pathway, Desipramine Action Pathway, Dezocine Action Pathway, Dibucaine Action Pathway, Dihydromorphine Action Pathway, Diltiazem Action Pathway, Dimethylthiambutene Action Pathway, Diphenoxylate Action Pathway, Disopyramide Action Pathway, Dobutamine Action Pathway, Epinephrine Action Pathway, Escitalopram Action Pathway, Esmolol Action Pathway, Ethylmorphine Action Pathway, Felodipine Action Pathway, Fentanyl Action Pathway, Flecainide Action Pathway, Fluoxetine Action Pathway, Fosphenytoin (Antiarrhythmic) Action Pathway, Heroin Action Pathway, Hydrocodone Action Pathway, Hydromorphone Action Pathway, Ibutilide Action Pathway, Imipramine Action Pathway, Isoprenaline Action Pathway, Isradipine Action Pathway, Ketobemidone Action Pathway, Labetalol Action Pathway, Levallorphan Action Pathway, Levobunolol Action Pathway, Levobupivacaine Action Pathway, Levomethadyl Acetate Action Action Pathway, Levorphanol Action Pathway, Lidocaine (Antiarrhythmic) Action Pathway, Lidocaine (Local Anaesthetic) Action Pathway, Mepivacaine Action Pathway, Methadone Action Pathway, Methadyl Acetate Action Pathway, Metipranolol Action Pathway, Metoprolol Action Pathway, Mexiletine Action Pathway, Morphine Action Pathway, Muscle contraction, Muscle/Heart Contraction, Nadolol Action Pathway, Nalbuphine Action Pathway, Naloxone Action Pathway, Naltrexone Action Pathway, Nebivolol Action Pathway, Nicotine Action Pathway, Nifedipine Action Pathway, Nimodipine Action Pathway, Nisoldipine Action Pathway, Nitrendipine Action Pathway, Oxprenolol Action Pathway, Oxybuprocaine Action Pathway, Oxycodone Action Pathway, Oxymorphone Action Pathway, Penbutolol Action Pathway, Pentazocine Action Pathway, Phase 1 - inactivation of fast Na+ channels, Phenytoin (Antiarrhythmic) Action Pathway, Pindolol Action Pathway, Practolol Action Pathway, Prilocaine Action Pathway, Procainamide (Antiarrhythmic) Action Pathway, Procaine Action Pathway, Proparacaine Action Pathway, Propoxyphene Action Pathway, Propranolol Action Pathway, Quinidine Action Pathway, Remifentanil Action Pathway, Ropivacaine Action Pathway, Sotalol Action Pathway, Sufentanil Action Pathway, Timolol Action Pathway, Tocainide Action Pathway, Tramadol Action Action Pathway, Verapamil Action Pathway
UniProt: Q9NS61
Entrez ID: 30819
|
Does Knockout of SLC1A5 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals?
| 0
| 2,383
|
Knockout
|
SLC1A5
|
response to chemicals
|
Chronic Myelogenous Leukemia Cell Line
|
Gene: SLC1A5 (solute carrier family 1 member 5)
Type: protein-coding
Summary: The SLC1A5 gene encodes a sodium-dependent neutral amino acid transporter that can act as a receptor for RD114/type D retrovirus (Larriba et al., 2001 [PubMed 11781704]).[supplied by OMIM, Jan 2011].
Gene Ontology: BP: L-aspartate import across plasma membrane, L-glutamine import across plasma membrane, L-serine transport, amino acid transport, erythrocyte differentiation, glutamine secretion, glutamine transport, neutral amino acid transport, protein homotrimerization, symbiont entry into host cell, transport across blood-brain barrier; MF: L-aspartate transmembrane transporter activity, L-glutamine transmembrane transporter activity, L-serine transmembrane transporter activity, amino acid transmembrane transporter activity, antiporter activity, ligand-gated channel activity, metal ion binding, neutral L-amino acid transmembrane transporter activity, protein binding, signaling receptor activity, symporter activity, virus receptor activity; CC: basal plasma membrane, centriolar satellite, ciliary basal body, extracellular exosome, melanosome, membrane, plasma membrane
Pathways: Amino acid transport across the plasma membrane, Argininemia, Argininosuccinic Aciduria, Carbamoyl Phosphate Synthetase Deficiency, Central carbon metabolism in cancer - Homo sapiens (human), Citrullinemia Type I, Glutaminolysis and Cancer, Metabolic reprogramming in colon cancer, Ornithine Transcarbamylase Deficiency (OTC Deficiency), Protein digestion and absorption - Homo sapiens (human), RAC1 GTPase cycle, RAC3 GTPase cycle, RHO GTPase cycle, RHOH GTPase cycle, RHOJ GTPase cycle, RHOQ GTPase cycle, SLC-mediated transmembrane transport, SLC-mediated transport of amino acids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, TYROBP causal network in microglia, Transport of small molecules, Urea Cycle, Warburg Effect
UniProt: Q15758
Entrez ID: 6510
|
Does Knockout of TMEM230 in Colorectal Cancer Cell Line causally result in cell proliferation?
| 0
| 783
|
Knockout
|
TMEM230
|
cell proliferation
|
Colorectal Cancer Cell Line
|
Gene: TMEM230 (transmembrane protein 230)
Type: protein-coding
Summary: This gene encodes a multi-pass transmembrane protein that belongs to the TMEM134/TMEM230 protein family. The encoded protein localizes to secretory and recycling vesicle in the neuron and may be involved in synaptic vesicles trafficking and recycling. Mutations in this gene may be linked to familial Parkinson's disease. [provided by RefSeq, Mar 2017].
Gene Ontology: BP: axonal transport, synaptic vesicle transport; CC: Golgi apparatus, autophagosome, axon, cytoplasmic vesicle, early endosome, endomembrane system, endoplasmic reticulum, endosome, late endosome, membrane, recycling endosome, synapse, synaptic vesicle, trans-Golgi network
Pathways:
UniProt: Q96A57
Entrez ID: 29058
|
Does Knockout of PSMD1 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 0
| 2,114
|
Knockout
|
PSMD1
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: PSMD1 (proteasome 26S subunit, non-ATPase 1)
Type: protein-coding
Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes the largest non-ATPase subunit of the 19S regulator lid, which is responsible for substrate recognition and binding. There is evidence that this proteasome and its subunits interact with viral proteins, including those of coronaviruses. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Aug 2020].
Gene Ontology: BP: proteasome-mediated ubiquitin-dependent protein catabolic process, regulation of protein catabolic process; MF: enzyme regulator activity, protein binding, ubiquitin protein ligase binding; CC: azurophil granule lumen, cytosol, extracellular region, membrane, nucleoplasm, nucleus, proteasome accessory complex, proteasome complex, proteasome regulatory particle, proteasome regulatory particle, base subcomplex, proteasome storage granule
Pathways: Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Epstein-Barr virus infection - Homo sapiens (human), Huntington disease - Homo sapiens (human), Parkin-Ubiquitin Proteasomal System pathway, Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Prion disease - Homo sapiens (human), Proteasome - Homo sapiens (human), Proteasome Degradation, Spinocerebellar ataxia - Homo sapiens (human), TNFalpha
UniProt: Q99460
Entrez ID: 5707
|
Does Knockout of FAM186B in Renal Cancer Cell Line causally result in cell proliferation?
| 0
| 319
|
Knockout
|
FAM186B
|
cell proliferation
|
Renal Cancer Cell Line
|
Gene: FAM186B (family with sequence similarity 186 member B)
Type: protein-coding
Summary: This gene product is a member of the FAM186 family, however, its exact function is not known. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2009].
Gene Ontology:
Pathways: IL-18 signaling pathway
UniProt: Q8IYM0
Entrez ID: 84070
|
Does Knockout of SCARB1 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,576
|
Knockout
|
SCARB1
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: SCARB1 (scavenger receptor class B member 1)
Type: protein-coding
Summary: The protein encoded by this gene is a plasma membrane receptor for high density lipoprotein cholesterol (HDL). The encoded protein mediates cholesterol transfer to and from HDL. In addition, this protein is a receptor for hepatitis C virus glycoprotein E2 and facilitates cell entry by the virus, SARS-CoV2. [provided by RefSeq, Oct 2021].
Gene Ontology: BP: adhesion of symbiont to host, blood vessel endothelial cell migration, cholesterol catabolic process, cholesterol efflux, cholesterol homeostasis, cholesterol import, cholesterol transport, detection of lipopolysaccharide, endothelial cell proliferation, high density lipoprotein particle mediated signaling, high-density lipoprotein particle clearance, high-density lipoprotein particle remodeling, intestinal lipid absorption, lipid transport, lipopolysaccharide transport, lipopolysaccharide-mediated signaling pathway, low-density lipoprotein particle clearance, phospholipid transport, plasma lipoprotein particle clearance, positive regulation of cholesterol storage, positive regulation of endothelial cell migration, positive regulation of nitric oxide mediated signal transduction, positive regulation of sphingolipid mediated signaling pathway, positive regulation of triglyceride biosynthetic process, recognition of apoptotic cell, regulation of phagocytosis, regulation of phosphatidylcholine catabolic process, reverse cholesterol transport, symbiont entry into host cell, triglyceride homeostasis, vasodilation, vitamin transmembrane transport, wound healing; MF: 1-phosphatidylinositol binding, amyloid-beta binding, apolipoprotein A-I binding, apolipoprotein binding, high-density lipoprotein particle binding, high-density lipoprotein particle receptor activity, lipid binding, lipopolysaccharide binding, lipopolysaccharide immune receptor activity, low-density lipoprotein particle binding, phosphatidylserine binding, protein binding, scavenger receptor activity, virus receptor activity; CC: caveola, cell surface, cytoplasm, endocytic vesicle membrane, extracellular exosome, lysosomal membrane, lysosome, membrane, plasma membrane
Pathways: Aldosterone synthesis and secretion - Homo sapiens (human), Bile secretion - Homo sapiens (human), Binding and Uptake of Ligands by Scavenger Receptors, Cholesterol metabolism - Homo sapiens (human), Cortisol synthesis and secretion - Homo sapiens (human), Cushing syndrome - Homo sapiens (human), Fat digestion and absorption - Homo sapiens (human), Folate Metabolism, HDL clearance, Hepatitis C - Homo sapiens (human), Ovarian steroidogenesis - Homo sapiens (human), Phagosome - Homo sapiens (human), Plasma lipoprotein assembly, remodeling, and clearance, Plasma lipoprotein clearance, SARS-CoV-2 and COVID-19 Pathway, Scavenging by Class B Receptors, Selenium Micronutrient Network, Statin inhibition of cholesterol production, Sterol regulatory element-binding proteins (SREBP) signaling, Transport of small molecules, Vesicle-mediated transport, Vitamin A and carotenoid metabolism, Vitamin B12 metabolism, Vitamin digestion and absorption - Homo sapiens (human)
UniProt: Q8WTV0
Entrez ID: 949
|
Does Activation of GUCA1C in Hepatoma Cell Line causally result in response to virus?
| 1
| 1,210
|
Activation
|
GUCA1C
|
response to virus
|
Hepatoma Cell Line
|
Gene: GUCA1C (guanylate cyclase activator 1C)
Type: protein-coding
Summary: Predicted to enable calcium ion binding activity and calcium sensitive guanylate cyclase activator activity. Predicted to be involved in signal transduction. Predicted to be located in photoreceptor disc membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: regulation of signal transduction, signal transduction, visual perception; MF: calcium ion binding, calcium sensitive guanylate cyclase activator activity, metal ion binding, protein binding; CC: photoreceptor disc membrane
Pathways: Inactivation, recovery and regulation of the phototransduction cascade, Phototransduction - Homo sapiens (human), Sensory Perception, The phototransduction cascade, Visual phototransduction, Visual signal transduction: Cones, Visual signal transduction: Rods
UniProt: O95843
Entrez ID: 9626
|
Does Knockout of THAP1 in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 787
|
Knockout
|
THAP1
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: THAP1 (THAP domain containing 1)
Type: protein-coding
Summary: The protein encoded by this gene contains a THAP domain, a conserved DNA-binding domain. This protein colocalizes with the apoptosis response protein PAWR/PAR-4 in promyelocytic leukemia (PML) nuclear bodies, and functions as a proapoptotic factor that links PAWR to PML nuclear bodies. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA-templated transcription, endothelial cell proliferation, negative regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of mitotic cell cycle, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, identical protein binding, metal ion binding, protein binding, protein homodimerization activity, sequence-specific DNA binding, zinc ion binding; CC: PML body, chromatin, fibrillar center, nucleoplasm, nucleus
Pathways:
UniProt: Q9NVV9
Entrez ID: 55145
|
Does Knockout of THSD1 in Lung Cancer Cell Line causally result in response to virus?
| 0
| 1,433
|
Knockout
|
THSD1
|
response to virus
|
Lung Cancer Cell Line
|
Gene: THSD1 (thrombospondin type 1 domain containing 1)
Type: protein-coding
Summary: The protein encoded by this gene contains a type 1 thrombospondin domain, which is found in a number of proteins involved in the complement pathway, as well as in extracellular matrix proteins. Alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Jan 2009].
Gene Ontology: MF: extracellular matrix binding, protein binding; CC: anchoring junction, cell periphery, cytoplasm, cytosol, endosome, endosome membrane, extracellular region, focal adhesion, membrane
Pathways: Defective B3GALTL causes PpS, Disease, Diseases associated with O-glycosylation of proteins, Diseases of glycosylation, Diseases of metabolism, Metabolism of proteins, O-glycosylation of TSR domain-containing proteins, O-linked glycosylation, Post-translational protein modification
UniProt: Q9NS62
Entrez ID: 55901
|
Does Knockout of CNOT7 in Cancer Cell Line causally result in cell proliferation?
| 0
| 193
|
Knockout
|
CNOT7
|
cell proliferation
|
Cancer Cell Line
|
Gene: CNOT7 (CCR4-NOT transcription complex subunit 7)
Type: protein-coding
Summary: The protein encoded by this gene binds to an anti-proliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of the anti-proliferative protein, causes signaling events in cell division that lead to changes in cell proliferation associated with cell-cell contact. The encoded protein downregulates the innate immune response and therefore provides a therapeutic target for enhancing its antimicrobial activity against foreign agents. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Apr 2016].
Gene Ontology: BP: P-body assembly, deadenylation-dependent decapping of nuclear-transcribed mRNA, defense response to virus, miRNA-mediated gene silencing by mRNA destabilization, negative regulation of DNA-templated transcription, negative regulation of cell population proliferation, negative regulation of gene expression, negative regulation of type I interferon-mediated signaling pathway, nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay, nuclear-transcribed mRNA poly(A) tail shortening, piRNA-mediated gene silencing by mRNA destabilization, positive regulation of cell population proliferation, positive regulation of mRNA catabolic process, positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay, positive regulation of nuclear-transcribed mRNA poly(A) tail shortening, positive regulation of transcription by RNA polymerase II, positive regulation of viral genome replication, regulation of translation, regulation of tyrosine phosphorylation of STAT protein, regulatory ncRNA-mediated gene silencing; MF: 3'-5'-RNA exonuclease activity, DNA-binding transcription factor binding, RNA binding, RNA exonuclease activity, exonuclease activity, hydrolase activity, metal ion binding, nuclease activity, nucleic acid binding, piRNA binding, poly(A)-specific ribonuclease activity, protein binding, transcription corepressor activity; CC: CCR4-NOT complex, CCR4-NOT core complex, P-body, cytoplasm, cytoplasmic ribonucleoprotein granule, cytosol, membrane, nuclear body, nuclear speck, nucleus
Pathways: Deadenylation of mRNA, Deadenylation-dependent mRNA decay, Developmental Biology, Gene expression (Transcription), Generic Transcription Pathway, M-decay: degradation of maternal mRNAs by maternally stored factors, Maternal to zygotic transition (MZT), Metabolism of RNA, RNA Polymerase II Transcription, RNA degradation - Homo sapiens (human), TP53 Regulates Transcription of Cell Cycle Genes, TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain, Transcriptional Regulation by TP53
UniProt: Q9UIV1
Entrez ID: 29883
|
Does Knockout of GSDMA in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,658
|
Knockout
|
GSDMA
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: GSDMA (gasdermin A)
Type: protein-coding
Summary: Predicted to enable phosphatidylinositol-4,5-bisphosphate binding activity; phosphatidylinositol-4-phosphate binding activity; and phosphatidylserine binding activity. Involved in apoptotic process. Located in perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: defense response to bacterium, programmed cell death, pyroptotic inflammatory response, transmembrane transport; MF: phosphatidylinositol-4,5-bisphosphate binding, phosphatidylinositol-4-phosphate binding, phosphatidylserine binding, protein binding, wide pore channel activity; CC: cytoplasm, cytosol, membrane, perinuclear region of cytoplasm, plasma membrane
Pathways:
UniProt: Q96QA5
Entrez ID: 284110
|
Does Activation of GMEB2 in Hepatoma Cell Line causally result in response to virus?
| 1
| 1,210
|
Activation
|
GMEB2
|
response to virus
|
Hepatoma Cell Line
|
Gene: GMEB2 (glucocorticoid modulatory element binding protein 2)
Type: protein-coding
Summary: This gene is a member of KDWK gene family. The product of this gene associates with GMEB1 protein, and the complex is essential for parvovirus DNA replication. Study of rat homolog implicates the role of this gene in modulation of transactivation by the glucocorticoid receptor bound to glucocorticoid response elements. This gene appears to use multiple polyadenylation sites. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: regulation of transcription by RNA polymerase II, transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, identical protein binding, metal ion binding, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: chromatin, cytoplasm, cytosol, nucleoplasm, nucleus
Pathways:
UniProt: Q9UKD1
Entrez ID: 26205
|
Does Knockout of MIR6874 in Monocytic Leukemia Cell Line causally result in response to chemicals?
| 0
| 1,978
|
Knockout
|
MIR6874
|
response to chemicals
|
Monocytic Leukemia Cell Line
|
Gene: MIR6874 (microRNA 6874)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 102466203
|
Does Knockout of COPG1 in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 787
|
Knockout
|
COPG1
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: COPG1 (coat protein complex I subunit gamma 1)
Type: protein-coding
Summary: Predicted to enable structural molecule activity. Predicted to be involved in several processes, including Golgi vesicle transport; establishment of Golgi localization; and organelle transport along microtubule. Located in Golgi apparatus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: endoplasmic reticulum to Golgi vesicle-mediated transport, establishment of Golgi localization, intra-Golgi vesicle-mediated transport, intracellular protein transport, organelle transport along microtubule, protein secretion, protein transport, vesicle-mediated transport; MF: protein binding, structural molecule activity; CC: COPI vesicle coat, COPI-coated vesicle membrane, Golgi apparatus, Golgi membrane, cytoplasm, cytoplasmic vesicle, cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum-Golgi intermediate compartment, membrane, membrane coat, organelle membrane, transport vesicle
Pathways: Asparagine N-linked glycosylation, COPI-dependent Golgi-to-ER retrograde traffic, COPI-mediated anterograde transport, ER to Golgi Anterograde Transport, Golgi-to-ER retrograde transport, Intra-Golgi and retrograde Golgi-to-ER traffic, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, Transport to the Golgi and subsequent modification, VEGFA-VEGFR2 Signaling Pathway, Vesicle-mediated transport
UniProt: Q9Y678
Entrez ID: 22820
|
Does Knockout of MIR320D2 in Monocytic Leukemia Cell Line causally result in response to chemicals?
| 1
| 1,978
|
Knockout
|
MIR320D2
|
response to chemicals
|
Monocytic Leukemia Cell Line
|
Gene: MIR320D2 (microRNA 320d-2)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID:
|
Does Knockout of VPS39 in Medulloblastoma Cell Line causally result in cell proliferation?
| 0
| 1,813
|
Knockout
|
VPS39
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: VPS39 (VPS39 subunit of HOPS complex)
Type: protein-coding
Summary: This gene encodes a protein that may promote clustering and fusion of late endosomes and lysosomes. The protein may also act as an adaptor protein that modulates the transforming growth factor-beta response by coupling the transforming growth factor-beta receptor complex to the Smad pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].
Gene Ontology: BP: autophagosome-lysosome fusion, autophagy, endocytic recycling, endosomal vesicle fusion, endosome to lysosome transport, intracellular protein transport, late endosome to lysosome transport, protein transport, regulation of SNARE complex assembly, vesicle-mediated transport; CC: AP-3 adaptor complex, HOPS complex, cytoplasm, endomembrane system, endosome, endosome membrane, late endosome, late endosome membrane, lysosomal HOPS complex, lysosomal membrane, lysosome, membrane
Pathways: Ebola Virus Pathway on Host, Salmonella infection - Homo sapiens (human), TGF_beta_Receptor, VEGFA-VEGFR2 Signaling Pathway
UniProt: Q96JC1
Entrez ID: 23339
|
Does Knockout of SIPA1L3 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 206
|
Knockout
|
SIPA1L3
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: SIPA1L3 (signal induced proliferation associated 1 like 3)
Type: protein-coding
Summary: This gene belongs to the signal induced proliferation associated 1 family of genes, which encode GTPase-activating proteins specific for the GTP-binding protein Rap1. Rap1 has been implicated in regulation of cell adhesion, cell polarity, and organization of the cytoskeleton. Like other members of the family, the protein encoded by this gene contains RapGAP and PDZ domains. In addition, this protein contains a C-terminal leucine zipper domain. This gene is proposed to function in epithelial cell morphogenesis and establishment or maintenance of polarity. Consistently, expression of the protein in cell culture showed localization to cell-cell borders in apical regions, and downregulation of the gene in 3D Caco2 cell culture resulted in abnormal cell polarity and morphogenesis. Allelic variants of this gene have been associated with congenital cataracts in humans. [provided by RefSeq, Feb 2016].
Gene Ontology: BP: cytoskeleton organization, epithelial cell morphogenesis, establishment of epithelial cell polarity, eye development, hematopoietic progenitor cell differentiation, regulation of small GTPase mediated signal transduction; MF: GTPase activator activity, protein binding; CC: Golgi apparatus, apical part of cell, apical plasma membrane, cytoplasm, extracellular space, glutamatergic synapse, membrane, nucleoplasm, plasma membrane, postsynaptic specialization, intracellular component, stress fiber, tricellular tight junction
Pathways: Rap1 signaling pathway - Homo sapiens (human)
UniProt: O60292
Entrez ID: 23094
|
Does Knockout of TLR1 in Gastric Cancer Cell Line causally result in cell proliferation?
| 0
| 787
|
Knockout
|
TLR1
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: TLR1 (toll like receptor 1)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is ubiquitously expressed, and at higher levels than other TLR genes. Different length transcripts presumably resulting from use of alternative polyadenylation site, and/or from alternative splicing, have been noted for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cellular response to triacyl bacterial lipopeptide, defense response, detection of triacyl bacterial lipopeptide, immune response, immune system process, inflammatory response, innate immune response, macrophage activation, microglial cell activation, positive regulation of interleukin-6 production, positive regulation of interleukin-8 production, positive regulation of toll-like receptor 2 signaling pathway, positive regulation of tumor necrosis factor production, response to bacterial lipoprotein, signal transduction, toll-like receptor signaling pathway; MF: NAD+ nucleosidase activity, cyclic ADP-ribose generating, Toll-like receptor 2 binding, identical protein binding, lipopeptide binding, protein binding, signaling receptor activity, transmembrane signaling receptor activity; CC: Golgi apparatus, Toll-like receptor 1-Toll-like receptor 2 protein complex, cytoplasmic vesicle, membrane, membrane raft, phagocytic vesicle membrane, plasma membrane, receptor complex
Pathways: Adaptive Immune System, Antigen processing-Cross presentation, Antimicrobial peptides, Beta defensins, Class I MHC mediated antigen processing & presentation, Defensins, Disease, Diseases associated with the TLR signaling cascade, Diseases of Immune System, ER-Phagosome pathway, Endogenous TLR signaling, IL1 and megakaryocytes in obesity, IRAK4 deficiency (TLR2/4), Immune System, Infectious disease, Innate Immune System, MyD88 deficiency (TLR2/4), MyD88:MAL(TIRAP) cascade initiated on plasma membrane, Regulation of TLR by endogenous ligand, Regulation of toll-like receptor signaling pathway, SARS-CoV Infections, SARS-CoV-2 Infection, SARS-CoV-2 activates/modulates innate and adaptive immune responses, SARS-CoV-2-host interactions, Simplified Depiction of MYD88 Distinct Input-Output Pathway, Toll Like Receptor 2 (TLR2) Cascade, Toll Like Receptor 4 (TLR4) Cascade, Toll Like Receptor TLR1:TLR2 Cascade, Toll Like Receptor TLR6:TLR2 Cascade, Toll-like Receptor Cascades, Toll-like Receptor Signaling Pathway, Toll-like Receptor Signaling related to MyD88, Toll-like receptor signaling pathway - Homo sapiens (human), Tuberculosis - Homo sapiens (human), Viral Infection Pathways
UniProt: Q15399
Entrez ID: 7096
|
Does Knockout of MYL3 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,339
|
Knockout
|
MYL3
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: MYL3 (myosin light chain 3)
Type: protein-coding
Summary: MYL3 encodes myosin light chain 3, an alkali light chain also referred to in the literature as both the ventricular isoform and the slow skeletal muscle isoform. Mutations in MYL3 have been identified as a cause of mid-left ventricular chamber type hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cardiac muscle contraction, muscle contraction, regulation of striated muscle contraction, regulation of the force of heart contraction, skeletal muscle tissue development, ventricular cardiac muscle tissue morphogenesis; MF: actin monomer binding, calcium ion binding, cytoskeletal motor activity, myosin II heavy chain binding, structural constituent of muscle; CC: A band, I band, cytosol, muscle myosin complex, myosin II complex, myosin complex, sarcomere
Pathways: Adrenergic signaling in cardiomyocytes - Homo sapiens (human), Apelin signaling pathway - Homo sapiens (human), Cardiac muscle contraction - Homo sapiens (human), Dilated cardiomyopathy - Homo sapiens (human), Hypertrophic cardiomyopathy - Homo sapiens (human), Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin, Muscle contraction, Regulation of Actin Cytoskeleton, Striated Muscle Contraction, Striated Muscle Contraction Pathway
UniProt: P08590
Entrez ID: 4634
|
Does Knockout of ATIC in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 2,459
|
Knockout
|
ATIC
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: ATIC (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase)
Type: protein-coding
Summary: This gene encodes a bifunctional protein that catalyzes the last two steps of the de novo purine biosynthetic pathway. The N-terminal domain has phosphoribosylaminoimidazolecarboxamide formyltransferase activity, and the C-terminal domain has IMP cyclohydrolase activity. A mutation in this gene results in AICA-ribosiduria. [provided by RefSeq, Sep 2009].
Gene Ontology: BP: 'de novo' AMP biosynthetic process, 'de novo' IMP biosynthetic process, 'de novo' XMP biosynthetic process, GMP biosynthetic process, animal organ regeneration, brainstem development, cellular response to interleukin-7, cerebellum development, cerebral cortex development, dihydrofolate metabolic process, nucleobase-containing compound metabolic process, purine nucleotide biosynthetic process, tetrahydrofolate biosynthetic process; MF: IMP cyclohydrolase activity, cadherin binding, catalytic activity, hydrolase activity, phosphoribosylaminoimidazolecarboxamide formyltransferase activity, protein homodimerization activity, transferase activity; CC: cytoplasm, cytosol, extracellular exosome, membrane, plasma membrane
Pathways: AICA-Ribosiduria, Adenine phosphoribosyltransferase deficiency (APRT), Adenosine Deaminase Deficiency, Adenylosuccinate Lyase Deficiency, Azathioprine Action Pathway, Disease, Diseases of signal transduction by growth factor receptors and second messengers, Gout or Kelley-Seegmiller Syndrome, Lesch-Nyhan Syndrome (LNS), Mercaptopurine Action Pathway, Metabolism, Metabolism of nucleotides, Mitochondrial DNA depletion syndrome, Molybdenum Cofactor Deficiency, Myoadenylate deaminase deficiency, Nucleotide biosynthesis, One carbon pool by folate - Homo sapiens (human), One-carbon metabolism, Purine Metabolism, Purine Nucleoside Phosphorylase Deficiency, Purine metabolism - Homo sapiens (human), Purine ribonucleoside monophosphate biosynthesis, Signaling by ALK fusions and activated point mutants, Signaling by ALK in cancer, Thioguanine Action Pathway, Xanthine Dehydrogenase Deficiency (Xanthinuria), Xanthinuria type I, Xanthinuria type II, inosine-5,-phosphate biosynthesis, purine nucleotides <i>de novo</i> biosynthesis
UniProt: P31939
Entrez ID: 471
|
Does Knockout of NUBPL in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals?
| 1
| 1,397
|
Knockout
|
NUBPL
|
response to chemicals
|
Chronic Myeloid Leukemia Cell Line
|
Gene: NUBPL (NUBP iron-sulfur cluster assembly factor, mitochondrial)
Type: protein-coding
Summary: This gene encodes a member of the Mrp/NBP35 ATP-binding proteins family. The encoded protein is required for the assembly of the respiratory chain NADH dehydrogenase (complex I), an oligomeric enzymatic complex located in the inner mitochondrial membrane. Mutations in this gene cause mitochondrial complex I deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014].
Gene Ontology: BP: iron-sulfur cluster assembly, mitochondrial respiratory chain complex I assembly, mitochondrion organization; MF: 4 iron, 4 sulfur cluster binding, ATP binding, ATP-dependent FeS chaperone activity, iron-sulfur cluster binding, metal ion binding, nucleotide binding, protein binding; CC: mitochondrial matrix, mitochondrion, plasma membrane
Pathways: Aerobic respiration and respiratory electron transport, Complex I biogenesis, Epithelial to mesenchymal transition in colorectal cancer, Metabolism, Respiratory electron transport
UniProt: Q8TB37
Entrez ID: 80224
|
Does Inhibition of EIF6 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals?
| 1
| 1,184
|
Inhibition
|
EIF6
|
response to chemicals
|
Chronic Myeloid Leukemia Cell Line
|
Gene: EIF6 (eukaryotic translation initiation factor 6)
Type: protein-coding
Summary: Hemidesmosomes are structures which link the basal lamina to the intermediate filament cytoskeleton. An important functional component of hemidesmosomes is the integrin beta-4 subunit (ITGB4), a protein containing two fibronectin type III domains. The protein encoded by this gene binds to the fibronectin type III domains of ITGB4 and may help link ITGB4 to the intermediate filament cytoskeleton. The encoded protein, which is insoluble and found both in the nucleus and in the cytoplasm, can function as a translation initiation factor and prevent the association of the 40S and 60S ribosomal subunits. Multiple non-protein coding transcript variants and variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2012].
Gene Ontology: BP: assembly of large subunit precursor of preribosome, cytosolic ribosome assembly, maturation of 5.8S rRNA, maturation of LSU-rRNA, miRNA-mediated gene silencing by inhibition of translation, miRNA-mediated post-transcriptional gene silencing, positive regulation of translation, regulation of fatty acid biosynthetic process, regulation of glycolytic process, regulation of megakaryocyte differentiation, regulation of reactive oxygen species metabolic process, response to insulin, ribosomal large subunit biogenesis, ribosomal subunit export from nucleus, ribosome biogenesis, translation, translational initiation; MF: protein binding, ribosomal large subunit binding, ribosome binding, translation initiation factor activity; CC: cytoplasm, cytosol, extracellular exosome, intermediate filament, lamin filament, nucleolus, nucleoplasm, nucleus, synapse
Pathways: Alpha6Beta4Integrin, Ribosome biogenesis in eukaryotes - Homo sapiens (human), Translation Factors, eukaryotic protein translation
UniProt: P56537
Entrez ID: 3692
|
Does Knockout of FCGR1A in Endometrial Cancer Cell Line causally result in cell proliferation?
| 0
| 758
|
Knockout
|
FCGR1A
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: FCGR1A (Fc gamma receptor Ia)
Type: protein-coding
Summary: This gene encodes a protein that plays an important role in the immune response. This protein is a high-affinity Fc-gamma receptor. The gene is one of three related gene family members located on chromosome 1. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: Fc-gamma receptor signaling pathway, antibody-dependent cellular cytotoxicity, antigen processing and presentation of exogenous antigen, antigen processing and presentation of exogenous peptide antigen via MHC class I, cell surface receptor signaling pathway, defense response to bacterium, immune response, immune system process, innate immune response, phagocytosis, engulfment, phagocytosis, recognition, positive regulation of phagocytosis, positive regulation of tumor necrosis factor production, positive regulation of type III hypersensitivity, positive regulation of type IIa hypersensitivity, receptor-mediated endocytosis, regulation of immune response, response to bacterium, signal transduction; MF: IgG binding, IgG receptor activity, high-affinity IgG receptor activity, protein binding; CC: clathrin-coated endocytic vesicle membrane, early endosome membrane, external side of plasma membrane, membrane, plasma membrane
Pathways: Acute myeloid leukemia - Homo sapiens (human), Adaptive Immune System, Anti-inflammatory response favouring Leishmania parasite infection, Antigen processing-Cross presentation, Class I MHC mediated antigen processing & presentation, Cross-presentation of soluble exogenous antigens (endosomes), Cytokine Signaling in Immune system, Disease, FCGR activation, FCGR3A-mediated IL10 synthesis, Fc gamma R-mediated phagocytosis - Homo sapiens (human), Fcgamma receptor (FCGR) dependent phagocytosis, Hematopoietic cell lineage - Homo sapiens (human), Immune System, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, Infectious disease, Innate Immune System, Interferon Signaling, Interferon gamma signaling, Leishmania infection, Leishmania parasite growth and survival, Leishmaniasis - Homo sapiens (human), Microglia Pathogen Phagocytosis Pathway, Neutrophil extracellular trap formation - Homo sapiens (human), Osteoclast differentiation - Homo sapiens (human), Parasitic Infection Pathways, Phagosome - Homo sapiens (human), Regulation of actin dynamics for phagocytic cup formation, Role of phospholipids in phagocytosis, Staphylococcus aureus infection - Homo sapiens (human), Systemic lupus erythematosus - Homo sapiens (human), Transcriptional misregulation in cancer - Homo sapiens (human), Tuberculosis - Homo sapiens (human)
UniProt: P12314
Entrez ID: 2209
|
Does Knockout of KAZN in Astrocytoma Cell Line causally result in cell proliferation?
| 0
| 904
|
Knockout
|
KAZN
|
cell proliferation
|
Astrocytoma Cell Line
|
Gene: KAZN (kazrin, periplakin interacting protein)
Type: protein-coding
Summary: This gene encodes a protein that plays a role in desmosome assembly, cell adhesion, cytoskeletal organization, and epidermal differentiation. This protein co-localizes with desmoplakin and the cytolinker protein periplakin. In general, this protein localizes to the nucleus, desmosomes, cell membrane, and cortical actin-based structures. Some isoforms of this protein also associate with microtubules. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their biological validity has not been verified. [provided by RefSeq, Aug 2011].
Gene Ontology: CC: anchoring junction, cornified envelope, cytoplasm, cytoskeleton, cytosol, desmosome, nuclear speck, nucleoplasm, nucleus
Pathways:
UniProt: Q674X7
Entrez ID: 23254
|
Does Knockout of SDHD in Cancer Cell Line causally result in cell proliferation?
| 1
| 193
|
Knockout
|
SDHD
|
cell proliferation
|
Cancer Cell Line
|
Gene: SDHD (succinate dehydrogenase complex subunit D)
Type: protein-coding
Summary: This gene encodes a member of complex II of the respiratory chain, which is responsible for the oxidation of succinate. The encoded protein is one of two integral membrane proteins anchoring the complex to the matrix side of the mitochondrial inner membrane. Mutations in this gene are associated with the formation of tumors, including hereditary paraganglioma. Transmission of disease occurs almost exclusively through the paternal allele, suggesting that this locus may be maternally imprinted. There are pseudogenes for this gene on chromosomes 1, 2, 3, 7, and 18. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013].
Gene Ontology: BP: cellular response to hypoxia, mitochondrial electron transport, succinate to ubiquinone, proton motive force-driven mitochondrial ATP synthesis, regulation of catecholamine secretion, tricarboxylic acid cycle; MF: electron transfer activity, heme binding, metal ion binding, protein binding, succinate dehydrogenase (quinone) activity, ubiquinone binding; CC: membrane, mitochondrial envelope, mitochondrial inner membrane, mitochondrion, respiratory chain complex II (succinate dehydrogenase)
Pathways: 2-ketoglutarate dehydrogenase complex deficiency, Aerobic respiration and respiratory electron transport, Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Citrate cycle (TCA cycle) - Homo sapiens (human), Citric Acid Cycle, Citric acid cycle (TCA cycle), Congenital lactic acidosis, Diabetic cardiomyopathy - Homo sapiens (human), Electron Transport Chain (OXPHOS system in mitochondria), Fumarase deficiency, Glutaminolysis and Cancer, Huntington disease - Homo sapiens (human), Maturation of TCA enzymes and regulation of TCA cycle, Metabolism, Mitochondrial CII Assembly, Mitochondrial Electron Transport Chain, Mitochondrial complex II deficiency, Non-alcoholic fatty liver disease - Homo sapiens (human), Nonalcoholic fatty liver disease, Oxidative phosphorylation - Homo sapiens (human), Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Prion disease - Homo sapiens (human), Pyruvate dehydrogenase deficiency (E2), Pyruvate dehydrogenase deficiency (E3), Respiratory electron transport, TCA Cycle (aka Krebs or citric acid cycle), TCA cycle, The oncogenic action of 2-hydroxyglutarate, The oncogenic action of D-2-hydroxyglutarate in Hydroxygluaricaciduria , The oncogenic action of Fumarate, The oncogenic action of L-2-hydroxyglutarate in Hydroxygluaricaciduria, The oncogenic action of Succinate, Thermogenesis - Homo sapiens (human), Warburg Effect, superpathway of conversion of glucose to acetyl CoA and entry into the TCA cycle
UniProt: O14521
Entrez ID: 6392
|
Does Knockout of MAP3K12 in Primary Effusion Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,061
|
Knockout
|
MAP3K12
|
response to chemicals
|
Primary Effusion Lymphoma Cell Line
|
Gene: MAP3K12 (mitogen-activated protein kinase kinase kinase 12)
Type: protein-coding
Summary: This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.[provided by RefSeq, Jul 2010].
Gene Ontology: BP: JNK cascade, intracellular signal transduction, negative regulation of motor neuron apoptotic process, positive regulation of DNA-templated transcription, positive regulation of ERK1 and ERK2 cascade, post-translational protein modification, protein autophosphorylation, protein phosphorylation, regulation of macromolecule metabolic process, regulation of primary metabolic process; MF: ATP binding, MAP kinase kinase kinase activity, kinase activity, nucleotide binding, protein binding, protein homodimerization activity, protein kinase activity, protein kinase binding, protein serine kinase activity, protein serine/threonine kinase activator activity, protein serine/threonine kinase activity, transferase activity; CC: axon, cytoplasm, cytosol, growth cone, membrane, plasma membrane
Pathways: Angiopoietin Like Protein 8 Regulatory Pathway, Insulin Signaling, MAPK Cascade, MAPK Signaling Pathway, MAPK signaling pathway - Homo sapiens (human), Regulation of p38-alpha and p38-beta, mapkinase signaling pathway
UniProt: Q12852
Entrez ID: 7786
|
Does Knockout of DDOST in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 230
|
Knockout
|
DDOST
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: DDOST (dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit)
Type: protein-coding
Summary: This gene encodes a component of the oligosaccharyltransferase complex which catalyzes the transfer of high-mannose oligosaccharides to asparagine residues on nascent polypeptides in the lumen of the rough endoplasmic reticulum. The protein complex co-purifies with ribosomes. The product of this gene is also implicated in the processing of advanced glycation endproducts (AGEs), which form from non-enzymatic reactions between sugars and proteins or lipids and are associated with aging and hyperglycemia. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: T cell activation, protein N-linked glycosylation, protein N-linked glycosylation via asparagine, protein glycosylation, regulation of protein stability, response to cytokine; MF: enzyme activator activity, protein binding; CC: azurophil granule membrane, endoplasmic reticulum, endoplasmic reticulum membrane, intracellular membrane-bounded organelle, membrane, oligosaccharyltransferase complex, oligosaccharyltransferase complex A, oligosaccharyltransferase complex B, plasma membrane
Pathways: AGE-RAGE pathway, Adaptive Immune System, Adherens junctions interactions, Advanced glycosylation endproduct receptor signaling, Asparagine N-linked glycosylation, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Co-inhibition by PD-1, Disease, Immune System, Infectious disease, Innate Immune System, Late SARS-CoV-2 Infection Events, Maturation of spike protein, Metabolism of proteins, N-Glycan biosynthesis - Homo sapiens (human), Neutrophil degranulation, PD-L1(CD274) glycosylation and translocation to plasma membrane, Post-translational protein modification, Protein processing in endoplasmic reticulum - Homo sapiens (human), Regulation of CDH1 Expression and Function, Regulation of CDH1 posttranslational processing and trafficking to plasma membrane, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of T cell activation by CD28 family, SARS-CoV Infections, SARS-CoV-2 Infection, SRP-dependent cotranslational protein targeting to membrane, Translation, Translation of Structural Proteins, Various types of N-glycan biosynthesis - Homo sapiens (human), Viral Infection Pathways
UniProt: P39656
Entrez ID: 1650
|
Does Knockout of KRTAP12-2 in T-lymphoma cell line causally result in cell proliferation?
| 0
| 478
|
Knockout
|
KRTAP12-2
|
cell proliferation
|
T-lymphoma cell line
|
Gene: KRTAP12-2 (keratin associated protein 12-2)
Type: protein-coding
Summary: Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: cytosol, intermediate filament
Pathways: Developmental Biology, Keratinization, Vitamin D Receptor Pathway
UniProt: P59991
Entrez ID: 353323
|
Does Knockout of RUVBL2 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 815
|
Knockout
|
RUVBL2
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: RUVBL2 (RuvB like AAA ATPase 2)
Type: protein-coding
Summary: This gene encodes the second human homologue of the bacterial RuvB gene. Bacterial RuvB protein is a DNA helicase essential for homologous recombination and DNA double-strand break repair. Functional analysis showed that this gene product has both ATPase and DNA helicase activities. This gene is physically linked to the CGB/LHB gene cluster on chromosome 19q13.3, and is very close (55 nt) to the LHB gene, in the opposite orientation. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, box C/D snoRNP assembly, cellular response to UV, cellular response to estradiol stimulus, chromatin organization, chromatin remodeling, establishment of protein localization to chromatin, negative regulation of DNA-templated transcription, negative regulation of canonical Wnt signaling pathway, positive regulation of DNA repair, positive regulation of DNA-templated transcription, positive regulation of double-strand break repair via homologous recombination, positive regulation of telomere maintenance in response to DNA damage, positive regulation of transcription by RNA polymerase II, protein folding, protein stabilization, regulation of DNA repair, regulation of DNA replication, regulation of DNA strand elongation, regulation of DNA-templated transcription, regulation of apoptotic process, regulation of cell cycle, regulation of chromosome organization, regulation of double-strand break repair, regulation of embryonic development, regulation of transcription by RNA polymerase II, telomerase RNA localization to Cajal body, telomere maintenance; MF: ADP binding, ATP binding, ATP hydrolysis activity, ATP-dependent activity, acting on DNA, ATPase binding, DNA helicase activity, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II core promoter sequence-specific DNA binding, TBP-class protein binding, TFIID-class transcription factor complex binding, beta-catenin binding, chromatin DNA binding, helicase activity, hydrolase activity, identical protein binding, nucleotide binding, promoter-enhancer loop anchoring activity, protein binding, protein homodimerization activity, transcription corepressor activity, unfolded protein binding; CC: Ino80 complex, MLL1 complex, NuA4 histone acetyltransferase complex, R2TP complex, RPAP3/R2TP/prefoldin-like complex, Swr1 complex, centrosome, ciliary basal body, cytoplasm, cytosol, dynein axonemal particle, euchromatin, extracellular exosome, membrane, nuclear matrix, nucleoplasm, nucleosome, nucleus, protein folding chaperone complex, ribonucleoprotein complex
Pathways: ATF-2 transcription factor network, C-MYC pathway, Cell Cycle, Chromatin modifying enzymes, Chromatin organization, Chromosome Maintenance, Extension of Telomeres, HATs acetylate histones, Integrin-linked kinase signaling, Regulation of nuclear beta catenin signaling and target gene transcription, Telomere Extension By Telomerase, Telomere Maintenance, Validated targets of C-MYC transcriptional activation
UniProt: Q9Y230
Entrez ID: 10856
|
Does Knockout of MIR3936 in Hepatoma Cell Line causally result in response to virus?
| 0
| 2,447
|
Knockout
|
MIR3936
|
response to virus
|
Hepatoma Cell Line
|
Gene: MIR3936 (microRNA 3936)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 100500865
|
Does Knockout of TBCC in Colonic Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 1,736
|
Knockout
|
TBCC
|
response to chemicals
|
Colonic Adenocarcinoma Cell Line
|
Gene: TBCC (tubulin folding cofactor C)
Type: protein-coding
Summary: Cofactor C is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: post-chaperonin tubulin folding pathway, protein folding, tubulin complex assembly; MF: GTPase activity, protein binding, protein-folding chaperone binding, tubulin binding; CC: cytoplasm, cytoskeleton, cytosol, endoplasmic reticulum, microtubule, photoreceptor connecting cilium
Pathways: Metabolism of proteins, Post-chaperonin tubulin folding pathway, Protein folding
UniProt: Q15814
Entrez ID: 6903
|
Does Activation of KDM2A in T cell causally result in protein/peptide accumulation?
| 0
| 2,425
|
Activation
|
KDM2A
|
protein/peptide accumulation
|
T cell
|
Gene: KDM2A (lysine demethylase 2A)
Type: protein-coding
Summary: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains at least six highly degenerated leucine-rich repeats. This family member plays a role in epigenetic silencing. It nucleates at CpG islands and specifically demethylates both mono- and di-methylated lysine-36 of histone H3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012].
Gene Ontology: BP: chromatin organization, chromatin remodeling, circadian regulation of gene expression, double-strand break repair via nonhomologous end joining, negative regulation of transcription by competitive promoter binding, regulation of circadian rhythm, regulation of transcription by RNA polymerase II, rhythmic process; MF: DNA binding, dioxygenase activity, histone H3K36 demethylase activity, histone H3K36me/H3K36me2 demethylase activity, histone demethylase activity, metal ion binding, oxidoreductase activity, protein binding, transcription coregulator activity, unmethylated CpG binding, zinc ion binding; CC: chromosome, nucleoplasm, nucleus
Pathways: Chromatin modifying enzymes, Chromatin organization, HDMs demethylate histones, The oncogenic action of 2-hydroxyglutarate, The oncogenic action of D-2-hydroxyglutarate in Hydroxygluaricaciduria , The oncogenic action of Fumarate, The oncogenic action of L-2-hydroxyglutarate in Hydroxygluaricaciduria, The oncogenic action of Succinate
UniProt: Q9Y2K7
Entrez ID: 22992
|
Does Activation of CLDN15 in T cell causally result in protein/peptide accumulation?
| 0
| 2,425
|
Activation
|
CLDN15
|
protein/peptide accumulation
|
T cell
|
Gene: CLDN15 (claudin 15)
Type: protein-coding
Summary: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2010].
Gene Ontology: BP: bicellular tight junction assembly, calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules, cell adhesion, monoatomic ion transport, paracellular transport, regulation of intestinal D-glucose absorption, regulation of intestinal lipid absorption; MF: identical protein binding, paracellular tight junction channel activity, structural molecule activity; CC: anchoring junction, bicellular tight junction, lateral plasma membrane, membrane, plasma membrane, tight junction
Pathways: Cell adhesion molecules - Homo sapiens (human), Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Epithelial to mesenchymal transition in colorectal cancer, Hepatitis C - Homo sapiens (human), IL-18 signaling pathway, Leukocyte transendothelial migration - Homo sapiens (human), Pathogenic Escherichia coli infection - Homo sapiens (human), Tight junction - Homo sapiens (human), Tight junction interactions
UniProt: P56746
Entrez ID: 24146
|
Does Knockout of ANKRD44 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals?
| 0
| 1,397
|
Knockout
|
ANKRD44
|
response to chemicals
|
Chronic Myeloid Leukemia Cell Line
|
Gene: ANKRD44 (ankyrin repeat domain 44)
Type: protein-coding
Summary: ankyrin repeat domain 44
Gene Ontology:
Pathways:
UniProt: Q8N8A2
Entrez ID: 91526
|
Does Knockout of TOP1 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 80
|
Knockout
|
TOP1
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: TOP1 (DNA topoisomerase I)
Type: protein-coding
Summary: This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA. This gene is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA replication, DNA topological change, animal organ regeneration, cellular response to luteinizing hormone stimulus, chromatin remodeling, chromosome segregation, circadian regulation of gene expression, circadian rhythm, embryonic cleavage, peptidyl-serine phosphorylation, programmed cell death, rRNA transcription, response to cAMP, response to gamma radiation, response to temperature stimulus, response to xenobiotic stimulus, rhythmic process; MF: ATP binding, DNA binding, DNA binding, bending, DNA topoisomerase activity, DNA topoisomerase type I (single strand cut, ATP-independent) activity, RNA binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, chromatin DNA binding, chromatin binding, double-stranded DNA binding, isomerase activity, protein binding, protein domain specific binding, protein serine/threonine kinase activity, protein-containing complex binding, single-stranded DNA binding, supercoiled DNA binding; CC: P-body, chromosome, cytoplasm, dense fibrillar component, fibrillar center, male germ cell nucleus, nuclear chromosome, nucleolus, nucleoplasm, nucleus, perikaryon, protein-DNA complex
Pathways: AndrogenReceptor, Caspase Cascade in Apoptosis, Ebola Virus Pathway on Host, Irinotecan Action Pathway, Irinotecan Metabolism Pathway, Metabolism of proteins, Post-translational protein modification, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA replication proteins
UniProt: P11387
Entrez ID: 7150
|
Does Knockout of KCNIP3 in Lung Cancer Cell Line causally result in response to virus?
| 1
| 1,433
|
Knockout
|
KCNIP3
|
response to virus
|
Lung Cancer Cell Line
|
Gene: KCNIP3 (potassium voltage-gated channel interacting protein 3)
Type: protein-coding
Summary: This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: apoptotic process, monoatomic ion transmembrane transport, monoatomic ion transport, negative regulation of transcription by RNA polymerase II, potassium ion transmembrane transport, potassium ion transport, protein localization to plasma membrane, regulation of potassium ion transmembrane transport, regulation of signal transduction, signal transduction; MF: DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, calcium ion binding, metal ion binding, potassium channel activity, potassium channel regulator activity, protein binding; CC: Golgi apparatus, cytoplasm, cytosol, endoplasmic reticulum, membrane, monoatomic ion channel complex, nucleus, plasma membrane, voltage-gated potassium channel complex
Pathways: Cardiac conduction, Gene expression (Transcription), Generic Transcription Pathway, IL3, Muscle contraction, Phase 1 - inactivation of fast Na+ channels, RNA Polymerase II Transcription, Regulation of NPAS4 gene expression, Regulation of NPAS4 gene transcription, Thyroid stimulating hormone (TSH) signaling pathway, Transcriptional Regulation by NPAS4, repression of pain sensation by the transcriptional regulator dream
UniProt: Q9Y2W7
Entrez ID: 30818
|
Does Knockout of APOBEC1 in Large Cell Lung Cancer Cell Line causally result in cell proliferation?
| 0
| 734
|
Knockout
|
APOBEC1
|
cell proliferation
|
Large Cell Lung Cancer Cell Line
|
Gene: APOBEC1 (apolipoprotein B mRNA editing enzyme catalytic subunit 1)
Type: protein-coding
Summary: This gene encodes a member of the cytidine deaminase enzyme family. The encoded protein forms a multiple-protein editing holoenzyme with APOBEC1 complementation factor (ACF) and APOBEC1 stimulating protein (ASP). This holoenzyme is involved in the editing of C-to-U nucleotide bases in apolipoprotein B and neurofibromatosis-1 mRNAs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2015].
Gene Ontology: BP: chromosomal 5-methylcytosine DNA demethylation pathway, cytidine to uridine editing, establishment of localization in cell, lipid metabolic process, lipoprotein biosynthetic process, lipoprotein metabolic process, lipoprotein transport, low-density lipoprotein particle clearance, mRNA modification, mRNA processing, mRNA stabilization, negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, negative regulation of triglyceride metabolic process, positive regulation of gene expression via chromosomal CpG island demethylation, positive regulation of macromolecule metabolic process, regulation of cell population proliferation, regulation of mRNA metabolic process, regulation of macromolecule biosynthetic process, response to gamma radiation, triglyceride metabolic process; MF: RNA binding, catalytic activity, cytidine deaminase activity, hydrolase activity, mRNA 3'-UTR AU-rich region binding, metal ion binding, protein binding, zinc ion binding; CC: apolipoprotein B mRNA editing enzyme complex, cytoplasm, mRNA editing complex, nucleoplasm, nucleus
Pathways: Formation of the Editosome, Metabolism of RNA, mRNA Editing, mRNA Editing: C to U Conversion
UniProt: P41238
Entrez ID: 339
|
Does Knockout of OR10J4 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 0
| 1,246
|
Knockout
|
OR10J4
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: OR10J4 (olfactory receptor family 10 subfamily J member 4 (gene/pseudogene))
Type: protein-coding
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jan 2017].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, detection of chemical stimulus involved in sensory perception of smell, sensory perception of smell, signal transduction; MF: G protein-coupled receptor activity, odorant binding, olfactory receptor activity; CC: membrane, plasma membrane
Pathways: Expression and translocation of olfactory receptors, Olfactory Signaling Pathway, Olfactory transduction - Homo sapiens (human), Sensory Perception
UniProt: P0C629
Entrez ID: 391121
|
Does Knockout of METTL3 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 951
|
Knockout
|
METTL3
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: METTL3 (methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit)
Type: protein-coding
Summary: This gene encodes the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. This enzyme is involved in the posttranscriptional methylation of internal adenosine residues in eukaryotic mRNAs, forming N6-methyladenosine. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA damage response, RNA methylation, cell differentiation, cellular response to UV, circadian rhythm, dosage compensation by inactivation of X chromosome, endothelial to hematopoietic transition, forebrain radial glial cell differentiation, gliogenesis, immune system process, innate immune response, mRNA destabilization, mRNA export from nucleus, mRNA modification, mRNA processing, mRNA splicing, via spliceosome, methylation, negative regulation of Notch signaling pathway, negative regulation of type I interferon-mediated signaling pathway, oogenesis, positive regulation of cap-independent translational initiation, positive regulation of translation, primary miRNA processing, regulation of T cell differentiation, regulation of hematopoietic stem cell differentiation, regulation of meiotic cell cycle, rhythmic process, spermatogenesis, stem cell population maintenance; MF: RNA binding, RNA methyltransferase activity, S-adenosyl-L-methionine binding, mRNA binding, mRNA m(6)A methyltransferase activity, methyltransferase activity, protein binding, protein heterodimerization activity, transferase activity; CC: Golgi apparatus, RNA N6-methyladenosine methyltransferase complex, cytoplasm, cytosol, nuclear body, nuclear speck, nucleoplasm, nucleus, oxidoreductase complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, mRNA Processing
UniProt: Q86U44
Entrez ID: 56339
|
Does Inhibition of BTN3A1 in Mammary Epithelial Cell Line causally result in cell proliferation?
| 0
| 2,248
|
Inhibition
|
BTN3A1
|
cell proliferation
|
Mammary Epithelial Cell Line
|
Gene: BTN3A1 (butyrophilin subfamily 3 member A1)
Type: protein-coding
Summary: The butyrophilin (BTN) genes are a group of major histocompatibility complex (MHC)-associated genes that encode type I membrane proteins with 2 extracellular immunoglobulin (Ig) domains and an intracellular B30.2 (PRYSPRY) domain. Three subfamilies of human BTN genes are located in the MHC class I region: the single-copy BTN1A1 gene (MIM 601610) and the BTN2 (e.g., BTN2A1; MIM 613590) and BTN3 (e.g., BNT3A1) genes, which have undergone tandem duplication, resulting in 3 copies of each (summary by Smith et al., 2010 [PubMed 20208008]).[supplied by OMIM, Nov 2010].
Gene Ontology: BP: T cell receptor signaling pathway, activated T cell proliferation, adaptive immune response, immune system process, positive regulation of cytokine production, positive regulation of type II interferon production, regulation of cytokine production; MF: protein binding, signaling receptor binding; CC: external side of plasma membrane, membrane, plasma membrane
Pathways:
UniProt: O00481
Entrez ID: 11119
|
Does Knockout of EIF6 in Monocytic Leukemia Cell Line causally result in response to chemicals?
| 1
| 1,978
|
Knockout
|
EIF6
|
response to chemicals
|
Monocytic Leukemia Cell Line
|
Gene: EIF6 (eukaryotic translation initiation factor 6)
Type: protein-coding
Summary: Hemidesmosomes are structures which link the basal lamina to the intermediate filament cytoskeleton. An important functional component of hemidesmosomes is the integrin beta-4 subunit (ITGB4), a protein containing two fibronectin type III domains. The protein encoded by this gene binds to the fibronectin type III domains of ITGB4 and may help link ITGB4 to the intermediate filament cytoskeleton. The encoded protein, which is insoluble and found both in the nucleus and in the cytoplasm, can function as a translation initiation factor and prevent the association of the 40S and 60S ribosomal subunits. Multiple non-protein coding transcript variants and variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2012].
Gene Ontology: BP: assembly of large subunit precursor of preribosome, cytosolic ribosome assembly, maturation of 5.8S rRNA, maturation of LSU-rRNA, miRNA-mediated gene silencing by inhibition of translation, miRNA-mediated post-transcriptional gene silencing, positive regulation of translation, regulation of fatty acid biosynthetic process, regulation of glycolytic process, regulation of megakaryocyte differentiation, regulation of reactive oxygen species metabolic process, response to insulin, ribosomal large subunit biogenesis, ribosomal subunit export from nucleus, ribosome biogenesis, translation, translational initiation; MF: protein binding, ribosomal large subunit binding, ribosome binding, translation initiation factor activity; CC: cytoplasm, cytosol, extracellular exosome, intermediate filament, lamin filament, nucleolus, nucleoplasm, nucleus, synapse
Pathways: Alpha6Beta4Integrin, Ribosome biogenesis in eukaryotes - Homo sapiens (human), Translation Factors, eukaryotic protein translation
UniProt: P56537
Entrez ID: 3692
|
Does Knockout of RAB4A in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 865
|
Knockout
|
RAB4A
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: RAB4A (RAB4A, member RAS oncogene family)
Type: protein-coding
Summary: This gene is a member of the largest group in the Ras superfamily of small GTPases, which regulate membrane trafficking. The encoded protein is associated with early endosomes and is involved in their sorting and recycling. The protein also plays a role in regulating the recycling of receptors from endosomes to the plasma membrane. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012].
Gene Ontology: BP: Rab protein signal transduction, antigen processing and presentation, neurotransmitter receptor transport postsynaptic membrane to endosome, protein transport, regulation of endocytosis, small GTPase-mediated signal transduction, vesicle-mediated transport, vesicle-mediated transport in synapse; MF: G protein activity, GDP binding, GTP binding, GTPase activity, hydrolase activity, metal ion binding, nucleotide binding, protein binding; CC: cytoplasm, cytoplasmic vesicle membrane, early endosome membrane, endosome, extracellular exosome, glutamatergic synapse, insulin-responsive compartment, membrane, perinuclear region of cytoplasm, recycling endosome, recycling endosome membrane, vesicle
Pathways: 16p11.2 distal deletion syndrome, Endocytosis - Homo sapiens (human), Insulin Signaling, Intracellular trafficking proteins involved in CMT neuropathy, MET receptor recycling, Membrane Trafficking, Metabolism, Metabolism of lipids, Metabolism of proteins, PDGFR-beta signaling pathway, PI Metabolism, Phospholipid metabolism, Post-translational protein modification, RAB geranylgeranylation, Rab regulation of trafficking, Signal Transduction, Signaling by MET, Signaling by Receptor Tyrosine Kinases, Synthesis of PIPs at the plasma membrane, TBC/RABGAPs, Translocation of SLC2A4 (GLUT4) to the plasma membrane, VEGFA-VEGFR2 Signaling Pathway, Vesicle-mediated transport
UniProt: P20338
Entrez ID: 5867
|
Does Knockout of CEACAM6 in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 1,813
|
Knockout
|
CEACAM6
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: CEACAM6 (CEA cell adhesion molecule 6)
Type: protein-coding
Summary: This gene encodes a protein that belongs to the carcinoembryonic antigen (CEA) family whose members are glycosyl phosphatidyl inositol (GPI) anchored cell surface glycoproteins. Members of this family play a role in cell adhesion and are widely used as tumor markers in serum immunoassay determinations of carcinoma. This gene affects the sensitivity of tumor cells to adenovirus infection. The protein encoded by this gene acts as a receptor for adherent-invasive E. coli adhesion to the surface of ileal epithelial cells in patients with Crohn's disease. This gene is clustered with genes and pseudogenes of the cell adhesion molecules subgroup of the CEA family on chromosome 19. [provided by RefSeq, Apr 2014].
Gene Ontology: BP: apoptotic process, cell adhesion, heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules, homophilic cell adhesion via plasma membrane adhesion molecules, negative regulation of anoikis, positive regulation of cell migration, positive regulation of cell population proliferation, positive regulation of endothelial cell-matrix adhesion via fibronectin, positive regulation of heterotypic cell-cell adhesion; MF: identical protein binding, protein binding, protein heterodimerization activity; CC: apical plasma membrane, azurophil granule membrane, cell surface, extracellular space, membrane, plasma membrane, side of membrane
Pathways: Cell surface interactions at the vascular wall, Extracellular matrix organization, Fibronectin matrix formation, Hemostasis, Immune System, Innate Immune System, Neutrophil degranulation
UniProt: P40199
Entrez ID: 4680
|
Does Knockout of VCP in Breast Cancer Cell Line causally result in cell proliferation?
| 1
| 235
|
Knockout
|
VCP
|
cell proliferation
|
Breast Cancer Cell Line
|
Gene: VCP (valosin containing protein)
Type: protein-coding
Summary: This gene encodes a member of the AAA ATPase family of proteins. The encoded protein plays a role in protein degradation, intracellular membrane fusion, DNA repair and replication, regulation of the cell cycle, and activation of the NF-kappa B pathway. This protein forms a homohexameric complex that interacts with a variety of cofactors and extracts ubiquitinated proteins from lipid membranes or protein complexes. Mutations in this gene cause IBMPFD (inclusion body myopathy with paget disease of bone and frontotemporal dementia), ALS (amyotrophic lateral sclerosis) and Charcot-Marie-Tooth disease in human patients. [provided by RefSeq, Aug 2017].
Gene Ontology: BP: ATP metabolic process, DNA damage response, DNA repair, ERAD pathway, NAD+ metabolic process, aggresome assembly, autophagosome maturation, autophagy, canonical NF-kappaB signal transduction, cellular response to arsenite ion, cellular response to heat, cellular response to misfolded protein, cytoplasm protein quality control, double-strand break repair, endoplasmic reticulum stress-induced pre-emptive quality control, endoplasmic reticulum to Golgi vesicle-mediated transport, endoplasmic reticulum unfolded protein response, endosome to lysosome transport via multivesicular body sorting pathway, establishment of protein localization, flavin adenine dinucleotide catabolic process, interstrand cross-link repair, macroautophagy, mitotic spindle disassembly, negative regulation of hippo signaling, negative regulation of protein localization to chromatin, negative regulation of smoothened signaling pathway, positive regulation of ATP biosynthetic process, positive regulation of canonical Wnt signaling pathway, positive regulation of mitochondrial membrane potential, positive regulation of non-canonical NF-kappaB signal transduction, positive regulation of oxidative phosphorylation, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of protein K63-linked deubiquitination, positive regulation of protein catabolic process, positive regulation of protein-containing complex assembly, positive regulation of ubiquitin-dependent protein catabolic process, proteasomal protein catabolic process, proteasome-mediated ubiquitin-dependent protein catabolic process, protein ubiquitination, protein-DNA covalent cross-linking repair, regulation of aerobic respiration, regulation of apoptotic process, regulation of protein localization to chromatin, regulation of synapse organization, retrograde protein transport, ER to cytosol, stress granule disassembly, translesion synthesis, ubiquitin-dependent protein catabolic process, viral genome replication; MF: ADP binding, ATP binding, ATP hydrolysis activity, BAT3 complex binding, K48-linked polyubiquitin modification-dependent protein binding, MHC class I protein binding, RNA binding, deubiquitinase activator activity, hydrolase activity, identical protein binding, lipid binding, nucleotide binding, polyubiquitin modification-dependent protein binding, protein binding, protein domain specific binding, protein phosphatase binding, protein-containing complex binding, ubiquitin protein ligase binding, ubiquitin-like protein ligase binding, ubiquitin-modified protein reader activity, ubiquitin-specific protease binding; CC: ATPase complex, Derlin-1 retrotranslocation complex, VCP-NPL4-UFD1 AAA ATPase complex, VCP-NSFL1C complex, azurophil granule lumen, ciliary basal body, cytoplasm, cytoplasmic stress granule, cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, extracellular exosome, extracellular region, ficolin-1-rich granule lumen, glutamatergic synapse, intracellular membrane-bounded organelle, lipid droplet, nucleoplasm, nucleus, perinuclear region of cytoplasm, proteasome complex, protein-containing complex, secretory granule lumen, site of double-strand break, synapse
Pathways: ABC transporter disorders, ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), Adaptive Immune System, Aggrephagy, Amyotrophic lateral sclerosis - Homo sapiens (human), Asparagine N-linked glycosylation, Attachment and Entry, Autophagy, Cellular response to chemical stress, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Co-inhibition by PD-1, DNA Damage Bypass, DNA Repair, Defective CFTR causes cystic fibrosis, Deubiquitination, Disease, Diseases of signal transduction by growth factor receptors and second messengers, Disorders of transmembrane transporters, E3 ubiquitin ligases ubiquitinate target proteins, Early SARS-CoV-2 Infection Events, HSF1 activation, Hedgehog ligand biogenesis, Hh mutants abrogate ligand secretion, Hh mutants are degraded by ERAD, Immune System, Infectious disease, Innate Immune System, Josephin domain DUBs, KEAP1-NFE2L2 pathway, Legionellosis - Homo sapiens (human), Macroautophagy, Metabolism of proteins, N-glycan trimming in the ER and Calnexin/Calreticulin cycle, Neddylation, Neutrophil degranulation, Ovarian tumor domain proteases, Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Post-translational protein modification, Protein methylation, Protein processing in endoplasmic reticulum - Homo sapiens (human), Protein ubiquitination, RHO GTPase cycle, RHOH GTPase cycle, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of T cell activation by CD28 family, Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SARS-CoV Infections, SARS-CoV-1 Infection, SARS-CoV-2 Infection, Selective autophagy, Signal Transduction, Signaling by Hedgehog, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Translation, Translesion Synthesis by POLH, Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template, Transport of small molecules, Viral Infection Pathways
UniProt: P55072
Entrez ID: 7415
|
Does Knockout of CD14 in Hepatoma Cell Line causally result in response to virus?
| 0
| 2,447
|
Knockout
|
CD14
|
response to virus
|
Hepatoma Cell Line
|
Gene: CD14 (CD14 molecule)
Type: protein-coding
Summary: The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with other proteins to mediate the innate immune response to bacterial lipopolysaccharide, and to viruses. This gene has been identified as a target candidate in the treatment of SARS-CoV-2-infected patients to potentially lessen or inhibit a severe inflammatory response. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Aug 2020].
Gene Ontology: BP: apoptotic process, cell surface pattern recognition receptor signaling pathway, cell surface receptor signaling pathway, cellular response to diacyl bacterial lipopeptide, cellular response to lipopolysaccharide, cellular response to lipoteichoic acid, cellular response to molecule of bacterial origin, cellular response to triacyl bacterial lipopeptide, immune system process, inflammatory response, innate immune response, lipopolysaccharide-mediated signaling pathway, phagocytosis, positive regulation of cytokine production, positive regulation of endocytosis, positive regulation of interleukin-8 production, positive regulation of lipopolysaccharide-mediated signaling pathway, positive regulation of toll-like receptor 4 signaling pathway, positive regulation of tumor necrosis factor production, positive regulation of type I interferon production, positive regulation of type II interferon production, receptor-mediated endocytosis, response to bacterium, response to molecule of bacterial origin, toll-like receptor 4 signaling pathway; MF: lipopolysaccharide binding, lipopolysaccharide immune receptor activity, lipoteichoic acid binding, molecular carrier activity, opsonin receptor activity, peptidoglycan immune receptor activity, protein binding; CC: Golgi apparatus, cell surface, endosome membrane, external side of plasma membrane, extracellular exosome, extracellular region, extracellular space, lipopolysaccharide receptor complex, membrane, membrane raft, plasma membrane, secretory granule membrane, side of membrane
Pathways: Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE), Acute myeloid leukemia - Homo sapiens (human), Adaptive Immune System, Alpha4 beta1 integrin signaling events, Amoebiasis - Homo sapiens (human), Antigen processing-Cross presentation, Apoptosis, Beta1 integrin cell surface interactions, Caspase activation via Death Receptors in the presence of ligand, Caspase activation via extrinsic apoptotic signalling pathway, Class I MHC mediated antigen processing & presentation, Disease, Diseases associated with the TLR signaling cascade, Diseases of Immune System, ER-Phagosome pathway, Endogenous TLR signaling, Fibrin Complement Receptor 3 Signaling Pathway, Hematopoietic cell lineage - Homo sapiens (human), IKK complex recruitment mediated by RIP1, IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation, IRAK4 deficiency (TLR2/4), Immune System, Infectious disease, Innate Immune System, Legionellosis - Homo sapiens (human), Lipid and atherosclerosis - Homo sapiens (human), MAPK Signaling Pathway, MAPK signaling pathway - Homo sapiens (human), Macrophage markers, MyD88 deficiency (TLR2/4), MyD88 dependent cascade initiated on endosome, MyD88-independent TLR4 cascade , MyD88:MAL(TIRAP) cascade initiated on plasma membrane, NF-kappa B signaling pathway - Homo sapiens (human), Neutrophil degranulation, Pathogenic Escherichia coli infection, Pertussis - Homo sapiens (human), Phagosome - Homo sapiens (human), Programmed Cell Death, RSV-host interactions, Regulation of Actin Cytoskeleton, Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 , Regulation of TLR by endogenous ligand, Regulation of toll-like receptor signaling pathway, Respiratory Syncytial Virus Infection Pathway, Respiratory syncytial virus (RSV) attachment and entry, Salmonella infection - Homo sapiens (human), Shigellosis - Homo sapiens (human), TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, TRAF6-mediated induction of TAK1 complex within TLR4 complex, TRIF (TICAM1)-mediated TLR4 signaling , TRIF-mediated programmed cell death, Toll Like Receptor 2 (TLR2) Cascade, Toll Like Receptor 4 (TLR4) Cascade, Toll Like Receptor 7/8 (TLR7/8) Cascade, Toll Like Receptor 9 (TLR9) Cascade, Toll Like Receptor TLR1:TLR2 Cascade, Toll Like Receptor TLR6:TLR2 Cascade, Toll-like Receptor Cascades, Toll-like Receptor Signaling Pathway, Toll-like receptor signaling pathway - Homo sapiens (human), Transcriptional misregulation in cancer - Homo sapiens (human), Transfer of LPS from LBP carrier to CD14, Tuberculosis - Homo sapiens (human), Viral Infection Pathways, Vitamin D Receptor Pathway, inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages, toll-like receptor pathway
UniProt: P08571
Entrez ID: 929
|
Does Knockout of SMNDC1 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 334
|
Knockout
|
SMNDC1
|
cell proliferation
|
Esophageal Squamous Cell Carcinoma Cell Line
|
Gene: SMNDC1 (survival motor neuron domain containing 1)
Type: protein-coding
Summary: This gene is a paralog of SMN1 gene, which encodes the survival motor neuron protein, mutations in which are cause of autosomal recessive proximal spinal muscular atrophy. The protein encoded by this gene is a nuclear protein that has been identified as a constituent of the spliceosome complex. This gene is differentially expressed, with abundant levels in skeletal muscle, and may share similar cellular function as the SMN1 gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: RNA splicing, RNA splicing, via transesterification reactions, apoptotic process, mRNA processing; MF: RNA binding, protein binding; CC: Cajal body, cytoplasm, nuclear speck, nucleoplasm, nucleus, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Homo sapiens (human), mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: O75940
Entrez ID: 10285
|
Does Knockout of CLDN19 in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 387
|
Knockout
|
CLDN19
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: CLDN19 (claudin 19)
Type: protein-coding
Summary: The product of this gene belongs to the claudin family. It plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Defects in this gene are the cause of hypomagnesemia renal with ocular involvement (HOMGO). HOMGO is a progressive renal disease characterized by primary renal magnesium wasting with hypomagnesemia, hypercalciuria and nephrocalcinosis associated with severe ocular abnormalities such as bilateral chorioretinal scars, macular colobomata, significant myopia and nystagmus. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jun 2010].
Gene Ontology: BP: actin cytoskeleton organization, apical junction assembly, bicellular tight junction assembly, calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules, cell adhesion, cell junction assembly, negative regulation of cell migration, negative regulation of cell population proliferation, negative regulation of gene expression, neuronal action potential propagation, paracellular transport, positive regulation of gene expression, regulation of transepithelial transport, renal absorption, retinal pigment epithelium development, tight junction organization, visual perception; MF: cell-cell adhesion mediator activity, identical protein binding, paracellular tight junction channel activity, protein binding, structural molecule activity; CC: Schmidt-Lanterman incisure, anchoring junction, apical junction complex, basolateral plasma membrane, bicellular tight junction, cell junction, cytoplasm, membrane, mesaxon, nucleus, paranodal junction, perinuclear region of cytoplasm, plasma membrane, tight junction
Pathways: Cell adhesion molecules - Homo sapiens (human), Epithelial to mesenchymal transition in colorectal cancer, Hepatitis C - Homo sapiens (human), Leukocyte transendothelial migration - Homo sapiens (human), Pathogenic Escherichia coli infection - Homo sapiens (human), Tight junction - Homo sapiens (human)
UniProt: Q8N6F1
Entrez ID: 149461
|
Does Knockout of ZNF250 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,352
|
Knockout
|
ZNF250
|
response to chemicals
|
Cervical Adenocarcinoma Cell Line
|
Gene: ZNF250 (zinc finger protein 250)
Type: protein-coding
Summary: Enables identical protein binding activity and sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, identical protein binding, metal ion binding, protein binding, sequence-specific double-stranded DNA binding, zinc ion binding; CC: nucleus
Pathways: Herpes simplex virus 1 infection - Homo sapiens (human)
UniProt: P15622
Entrez ID: 58500
|
Does Knockout of CPSF3 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 1
| 2,114
|
Knockout
|
CPSF3
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: CPSF3 (cleavage and polyadenylation specific factor 3)
Type: protein-coding
Summary: This gene encodes a member of the metallo-beta-lactamase family. The encoded protein is a 73kDa subunit of the cleavage and polyadenylation specificity factor and functions as an endonuclease that recognizes the pre-mRNA 3'-cleavage site AAUAAA prior to polyadenylation. It also cleaves after the pre-mRNA sequence ACCCA during histone 3'-end pre-mRNA processing. [provided by RefSeq, Oct 2012].
Gene Ontology: BP: co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway, mRNA 3'-end processing, mRNA 3'-end processing by stem-loop binding and cleavage, mRNA processing, positive regulation of G1/S transition of mitotic cell cycle; MF: 5'-3' RNA exonuclease activity, RNA binding, RNA endonuclease activity, endonuclease activity, hydrolase activity, metal ion binding, nuclease activity, protein binding; CC: mRNA cleavage and polyadenylation specificity factor complex, nucleoplasm, nucleus, ribonucleoprotein complex
Pathways: Gene expression (Transcription), Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Processing of Capped Intronless Pre-mRNA, Processing of Intronless Pre-mRNAs, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, mRNA 3'-end processing, mRNA Processing, mRNA surveillance pathway - Homo sapiens (human), polyadenylation of mrna
UniProt: Q9UKF6
Entrez ID: 51692
|
Does Knockout of MED23 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 1,246
|
Knockout
|
MED23
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: MED23 (mediator complex subunit 23)
Type: protein-coding
Summary: The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein also acts as a metastasis suppressor. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2012].
Gene Ontology: BP: RNA polymerase II preinitiation complex assembly, positive regulation of T cell extravasation, positive regulation of gene expression, positive regulation of transcription elongation by RNA polymerase II, positive regulation of transcription initiation by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, transcription initiation at RNA polymerase II promoter; MF: protein binding, transcription coactivator activity; CC: core mediator complex, mediator complex, nucleoplasm, nucleus, transcription regulator complex
Pathways: Adipogenesis, Developmental Biology, Disease, Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes, Epigenetic regulation of gene expression, Epigenetic regulation of gene expression by MLL3 and MLL4 complexes, Gene expression (Transcription), Generic Transcription Pathway, Hedgehog, Infectious disease, MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis, Metabolism, Metabolism of lipids, PPARA activates gene expression, RNA Polymerase II Transcription, RSV-host interactions, Regulation of lipid metabolism by PPARalpha, Respiratory Syncytial Virus Infection Pathway, Transcriptional regulation of white adipocyte differentiation, Viral Infection Pathways
UniProt: Q9ULK4
Entrez ID: 9439
|
Does Knockout of WDR70 in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 408
|
Knockout
|
WDR70
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: WDR70 (WD repeat domain 70)
Type: protein-coding
Summary: Enables enzyme binding activity. Predicted to be involved in regulation of DNA double-strand break processing and regulation of histone H2B conserved C-terminal lysine ubiquitination. Predicted to be active in nucleus and site of double-strand break. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: nucleoplasm, nucleus, site of double-strand break
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q9NW82
Entrez ID: 55100
|
Does Knockout of GRIN3A in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,658
|
Knockout
|
GRIN3A
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: GRIN3A (glutamate ionotropic receptor NMDA type subunit 3A)
Type: protein-coding
Summary: This gene encodes a subunit of the N-methyl-D-aspartate (NMDA) receptors, which belong to the superfamily of glutamate-regulated ion channels, and function in physiological and pathological processes in the central nervous system. This subunit shows greater than 90% identity to the corresponding subunit in rat. Studies in the knockout mouse deficient in this subunit suggest that this gene may be involved in the development of synaptic elements by modulating NMDA receptor activity. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: calcium ion transmembrane transport, calcium ion transport, dendrite development, ionotropic glutamate receptor signaling pathway, modulation of chemical synaptic transmission, monoatomic cation transmembrane transport, monoatomic ion transmembrane transport, monoatomic ion transport, negative regulation of dendritic spine development, neuron development, prepulse inhibition, presynaptic modulation of chemical synaptic transmission, regulation of postsynaptic membrane potential, regulation of synaptic plasticity, response to ethanol, rhythmic process, synaptic transmission, glutamatergic; MF: NMDA glutamate receptor activity, calcium channel activity, glutamate receptor activity, glutamate-gated receptor activity, glycine binding, glycine-gated cation channel activity, identical protein binding, ligand-gated monoatomic ion channel activity, monoatomic ion channel activity, protein binding, protein phosphatase 2A binding, serine binding, signaling receptor activity, transmitter-gated monoatomic ion channel activity, transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential; CC: NMDA selective glutamate receptor complex, cytoplasm, endoplasmic reticulum membrane, glutamatergic synapse, membrane, monoatomic ion channel complex, neuron projection, neuronal cell body, neurotransmitter receptor complex, organelle, plasma membrane, postsynaptic density, postsynaptic density membrane, postsynaptic membrane, presynapse, synapse
Pathways: 3-Methylthiofentanyl Action Pathway, Activation of NMDA receptors and postsynaptic events, Alcoholism - Homo sapiens (human), Alfentanil Action Pathway, Alvimopan Action Pathway, Amphetamine addiction - Homo sapiens (human), Anileridine Action Pathway, Assembly and cell surface presentation of NMDA receptors, Benzocaine Action Pathway, Bupivacaine Action Pathway, Buprenorphine Action Pathway, Carfentanil Action Pathway, Chloroprocaine Action Pathway, Citalopram Action Pathway, Cocaine Action Pathway, Cocaine addiction - Homo sapiens (human), Codeine Action Pathway, Desipramine Action Pathway, Dezocine Action Pathway, Dibucaine Action Pathway, Dihydromorphine Action Pathway, Dimethylthiambutene Action Pathway, Diphenoxylate Action Pathway, Escitalopram Action Pathway, Ethylmorphine Action Pathway, Fentanyl Action Pathway, Fluoxetine Action Pathway, Glutamatergic synapse - Homo sapiens (human), Heroin Action Pathway, Hydrocodone Action Pathway, Hydromorphone Action Pathway, Imipramine Action Pathway, Ketobemidone Action Pathway, Levallorphan Action Pathway, Levobupivacaine Action Pathway, Levomethadyl Acetate Action Action Pathway, Levorphanol Action Pathway, Lidocaine (Local Anaesthetic) Action Pathway, Mepivacaine Action Pathway, Methadone Action Pathway, Methadone Metabolism Pathway, Methadyl Acetate Action Pathway, Morphine Action Pathway, Nalbuphine Action Pathway, Naloxone Action Pathway, Naltrexone Action Pathway, Neuroactive ligand-receptor interaction - Homo sapiens (human), Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, Nicotine Action Pathway, Nicotine addiction - Homo sapiens (human), Oxybuprocaine Action Pathway, Oxycodone Action Pathway, Oxymorphone Action Pathway, Pentazocine Action Pathway, Prilocaine Action Pathway, Prion disease - Homo sapiens (human), Procaine Action Pathway, Proparacaine Action Pathway, Propoxyphene Action Pathway, Remifentanil Action Pathway, Ropivacaine Action Pathway, Spinocerebellar ataxia - Homo sapiens (human), Sufentanil Action Pathway, Synaptic signaling pathways associated with autism spectrum disorder, Tramadol Action Action Pathway, Transmission across Chemical Synapses, cAMP signaling pathway - Homo sapiens (human)
UniProt: Q8TCU5
Entrez ID: 116443
|
Does Knockout of CYB5R2 in Bladder Carcinoma causally result in cell proliferation?
| 0
| 489
|
Knockout
|
CYB5R2
|
cell proliferation
|
Bladder Carcinoma
|
Gene: CYB5R2 (cytochrome b5 reductase 2)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the flavoprotein pyridine nucleotide cytochrome reductase family of proteins. Cytochrome b-type NAD(P)H oxidoreductases are implicated in many processes including cholesterol biosynthesis, fatty acid desaturation and elongation, and respiratory burst in neutrophils and macrophages. Cytochrome b5 reductases have soluble and membrane-bound forms that are the product of alternative splicing. In animal cells, the membrane-bound form binds to the endoplasmic reticulum, where it is a member of a fatty acid desaturation complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014].
Gene Ontology: BP: bicarbonate transport, lipid metabolic process, steroid biosynthetic process, steroid metabolic process, sterol biosynthetic process; MF: FAD binding, cytochrome-b5 reductase activity, acting on NAD(P)H, oxidoreductase activity, protein binding; CC: endoplasmic reticulum membrane, membrane, mitochondrion, nucleus
Pathways: Amino sugar and nucleotide sugar metabolism - Homo sapiens (human), Oxidation by Cytochrome P450
UniProt: Q6BCY4
Entrez ID: 51700
|
Does Knockout of OSTN in Melanoma Cell Line causally result in response to chemicals?
| 1
| 1,940
|
Knockout
|
OSTN
|
response to chemicals
|
Melanoma Cell Line
|
Gene: OSTN (osteocrin)
Type: protein-coding
Summary: Predicted to enable signaling receptor binding activity. Involved in negative regulation of dendrite extension. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: bone growth, cGMP biosynthetic process, cell differentiation, cell surface receptor signaling pathway, endochondral bone growth, hormone-mediated signaling pathway, negative regulation of D-glucose import, negative regulation of dendrite extension, negative regulation of osteoblast differentiation, regulation of blood pressure, regulation of osteoblast proliferation; MF: hormone activity, signaling receptor binding; CC: extracellular region, extracellular space
Pathways:
UniProt: P61366
Entrez ID: 344901
|
Does Knockout of AP1M2 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 0
| 758
|
Knockout
|
AP1M2
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: AP1M2 (adaptor related protein complex 1 subunit mu 2)
Type: protein-coding
Summary: This gene encodes a subunit of the heterotetrameric adaptor-related protein comlex 1 (AP-1), which belongs to the adaptor complexes medium subunits family. This protein is capable of interacting with tyrosine-based sorting signals. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].
Gene Ontology: BP: basolateral protein secretion, establishment of localization in cell, establishment of protein localization, intracellular protein transport, protein targeting, protein transport, vesicle targeting, vesicle-mediated transport; MF: clathrin adaptor activity, protein binding; CC: AP-1 adaptor complex, Golgi apparatus, Golgi membrane, clathrin adaptor complex, clathrin-coated vesicle, clathrin-coated vesicle membrane, cytoplasmic vesicle, cytoplasmic vesicle membrane, cytosol, lysosomal membrane, membrane, trans-Golgi network membrane
Pathways: Adaptive Immune System, Disease, Golgi Associated Vesicle Biogenesis, HIV Infection, Host Interactions of HIV factors, Human immunodeficiency virus 1 infection - Homo sapiens (human), Immune System, Infectious disease, Lysosome - Homo sapiens (human), Lysosome Vesicle Biogenesis, MHC class II antigen presentation, Membrane Trafficking, Nef mediated downregulation of MHC class I complex cell surface expression, Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters, The role of Nef in HIV-1 replication and disease pathogenesis, Vesicle-mediated transport, Viral Infection Pathways, trans-Golgi Network Vesicle Budding
UniProt: Q9Y6Q5
Entrez ID: 10053
|
Does Knockout of DEFB124 in Colorectal Cancer Cell Line causally result in response to chemicals?
| 0
| 1,414
|
Knockout
|
DEFB124
|
response to chemicals
|
Colorectal Cancer Cell Line
|
Gene: DEFB124 (defensin beta 124)
Type: protein-coding
Summary: Defensins are cysteine-rich cationic polypeptides that are important in the host immunologic response to invading microorganisms. This antimicrobial protein is secreted and is a member of the beta defensin protein family. Beta defensin genes are found in several clusters throughout the genome, with this gene mapping to a cluster at 20q11.1. The encoded protein may serve to enhance innate immunity in the prostate. [provided by RefSeq, Nov 2014].
Gene Ontology: BP: canonical NF-kappaB signal transduction, cellular response to peptidoglycan, defense response, defense response to bacterium, innate immune response, positive regulation of chemokine (C-C motif) ligand 5 production, positive regulation of chemokine (C-X-C motif) ligand 2 production, positive regulation of chemokine production, positive regulation of interleukin-12 production, positive regulation of interleukin-2 production, positive regulation of interleukin-6 production, positive regulation of monocyte chemotaxis
Pathways: Antimicrobial peptides, Beta defensins, Defensins, Immune System, Innate Immune System
UniProt: Q8NES8
Entrez ID: 245937
|
Does Knockout of PDCD11 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 69
|
Knockout
|
PDCD11
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: PDCD11 (programmed cell death 11)
Type: protein-coding
Summary: PDCD11 is a NF-kappa-B (NFKB1; 164011)-binding protein that colocalizes with U3 RNA (MIM 180710) in the nucleolus and is required for rRNA maturation and generation of 18S rRNA (Sweet et al., 2003 [PubMed 14624448]; Sweet et al., 2008 [PubMed 17654514]).[supplied by OMIM, Oct 2008].
Gene Ontology: BP: RNA processing, rRNA processing; MF: NF-kappaB binding, RNA binding, nucleic acid binding, protein binding; CC: cytosol, nucleolus, nucleoplasm, nucleus, small-subunit processome
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA modification in the nucleus and cytosol, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q14690
Entrez ID: 22984
|
Does Knockout of EIF1AX in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 80
|
Knockout
|
EIF1AX
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: EIF1AX (eukaryotic translation initiation factor 1A X-linked)
Type: protein-coding
Summary: This gene encodes an essential eukaryotic translation initiation factor. The protein is required for the binding of the 43S complex (a 40S subunit, eIF2/GTP/Met-tRNAi and eIF3) to the 5' end of capped RNA. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: ribosome assembly, translation, translational initiation; MF: RNA binding, protein binding, tRNA binding, translation factor activity, RNA binding, translation initiation factor activity; CC: cytoplasm, cytosol, eukaryotic 43S preinitiation complex, eukaryotic 48S preinitiation complex, multi-eIF complex, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Metabolism of proteins, RNA transport - Homo sapiens (human), Ribosomal scanning and start codon recognition, Translation, Translation Factors, Translation initiation complex formation, eukaryotic protein translation, nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell
UniProt: P47813
Entrez ID: 1964
|
Does Knockout of VPS18 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 206
|
Knockout
|
VPS18
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: VPS18 (VPS18 core subunit of CORVET and HOPS complexes)
Type: protein-coding
Summary: Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps18 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: autophagy, endosomal vesicle fusion, endosome organization, endosome to lysosome transport, intracellular protein transport, lysosome organization, negative regulation of intracellular estrogen receptor signaling pathway, organelle fusion, protein transport, protein ubiquitination, regulation of SNARE complex assembly, regulation of synaptic vesicle exocytosis, symbiont entry into host cell, vesicle docking involved in exocytosis, vesicle-mediated transport; MF: actin binding, metal ion binding, protein binding, protein-macromolecule adaptor activity, syntaxin binding, ubiquitin protein ligase activity, zinc ion binding; CC: AP-3 adaptor complex, CORVET complex, HOPS complex, actin filament, autophagosome, clathrin-coated vesicle, cytoplasmic vesicle, early endosome, endomembrane system, endosome, endosome membrane, glutamatergic synapse, late endosome, late endosome membrane, lysosomal membrane, lysosome, membrane, presynapse
Pathways: Disease, Ebola Virus Pathway on Host, Infectious disease, SARS-CoV Infections, SARS-CoV-2 Infection, SARS-CoV-2 modulates autophagy, SARS-CoV-2-host interactions, Salmonella infection - Homo sapiens (human), Viral Infection Pathways
UniProt: Q9P253
Entrez ID: 57617
|
Does Knockout of DOK2 in Melanoma Cell Line causally result in response to chemicals?
| 1
| 95
|
Knockout
|
DOK2
|
response to chemicals
|
Melanoma Cell Line
|
Gene: DOK2 (docking protein 2)
Type: protein-coding
Summary: The protein encoded by this gene is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. This encoded protein binds p120 (RasGAP) from CML cells. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: Ras protein signal transduction, cell surface receptor protein tyrosine kinase signaling pathway, cell surface receptor signaling pathway, signal transduction; MF: protein binding, transmembrane receptor protein tyrosine kinase adaptor activity; CC: cytoplasm, cytosol, plasma membrane
Pathways: Angiopoietin receptor Tie2-mediated signaling, Axon guidance, Cell surface interactions at the vascular wall, Developmental Biology, EGF-EGFR signaling pathway, EGFR1, Fibroblast growth factor-1, Hemostasis, IL-4 signaling pathway, IL2-mediated signaling events, IL4, IL4-mediated signaling events, Nervous system development, RAC1-PAK1-p38-MMP2 Pathway, RET signaling, TCR, Tie2 Signaling
UniProt: O60496
Entrez ID: 9046
|
Does Knockout of NPLOC4 in acute lymphoblastic leukemia cell line causally result in cell proliferation?
| 1
| 1,957
|
Knockout
|
NPLOC4
|
cell proliferation
|
acute lymphoblastic leukemia cell line
|
Gene: NPLOC4 (NPL4 homolog, ubiquitin recognition factor)
Type: protein-coding
Summary: Predicted to enable ATPase binding activity; ubiquitin binding activity; and ubiquitin protein ligase binding activity. Predicted to contribute to K48-linked polyubiquitin modification-dependent protein binding activity and K63-linked polyubiquitin modification-dependent protein binding activity. Involved in negative regulation of RIG-I signaling pathway; negative regulation of type I interferon production; and proteolysis involved in cellular protein catabolic process. Located in nucleus. Part of UFD1-NPL4 complex and VCP-NPL4-UFD1 AAA ATPase complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: ERAD pathway, Golgi organization, negative regulation of RIG-I signaling pathway, negative regulation of type I interferon production, proteasome-mediated ubiquitin-dependent protein catabolic process, retrograde protein transport, ER to cytosol, ubiquitin-dependent protein catabolic process; MF: ATPase binding, K48-linked polyubiquitin modification-dependent protein binding, K63-linked polyubiquitin modification-dependent protein binding, metal ion binding, protein binding, protein-containing complex binding, ubiquitin binding, ubiquitin protein ligase binding, zinc ion binding; CC: UFD1-NPL4 complex, VCP-NPL4-UFD1 AAA ATPase complex, cytoplasm, cytosol, endoplasmic reticulum, nuclear outer membrane-endoplasmic reticulum membrane network, nucleoplasm, nucleus
Pathways: Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, DNA Damage Bypass, DNA Repair, KEAP1-NFE2L2 pathway, Metabolism of proteins, Neddylation, Post-translational protein modification, Protein processing in endoplasmic reticulum - Homo sapiens (human), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, Translation, Translesion Synthesis by POLH, Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
UniProt: Q8TAT6
Entrez ID: 55666
|
Does Knockout of FDX1 in Hepatoma Cell Line causally result in response to virus?
| 1
| 2,437
|
Knockout
|
FDX1
|
response to virus
|
Hepatoma Cell Line
|
Gene: FDX1 (ferredoxin 1)
Type: protein-coding
Summary: This gene encodes a small iron-sulfur protein that transfers electrons from NADPH through ferredoxin reductase to mitochondrial cytochrome P450, involved in steroid, vitamin D, and bile acid metabolism. Pseudogenes of this functional gene are found on chromosomes 20 and 21. [provided by RefSeq, Aug 2011].
Gene Ontology: BP: P450-containing electron transport chain, cellular response to cAMP, cellular response to forskolin, cholesterol metabolic process, electron transport chain, hormone biosynthetic process, lipid metabolic process, steroid biosynthetic process, steroid metabolic process; MF: 2 iron, 2 sulfur cluster binding, electron transfer activity, iron ion binding, iron-sulfur cluster binding, metal ion binding; CC: mitochondrial matrix, mitochondrion
Pathways: Biological oxidations, Cytochrome P450 - arranged by substrate type, Defective CYP11A1 causes AICSR, Disease, Diseases of metabolism, Electron transport from NADPH to Ferredoxin, Endogenous sterols, Metabolic disorders of biological oxidation enzymes, Metabolism, Metabolism of lipids, Metabolism of proteins, Metabolism of steroid hormones, Metabolism of steroids, Mitochondrial iron-sulfur cluster biogenesis, Phase I - Functionalization of compounds, Post-translational protein modification, Pregnenolone biosynthesis, Protein lipoylation
UniProt: P10109
Entrez ID: 2230
|
Does Knockout of STRAP in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 69
|
Knockout
|
STRAP
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: STRAP (serine/threonine kinase receptor associated protein)
Type: protein-coding
Summary: Enables RNA binding activity. Involved in maintenance of gastrointestinal epithelium; negative regulation of transforming growth factor beta receptor signaling pathway; and spliceosomal snRNP assembly. Located in cytosol. Part of SMN complex. Implicated in adenocarcinoma; colorectal carcinoma; large cell carcinoma; lung carcinoma; and squamous cell neoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: RNA splicing, alternative mRNA splicing, via spliceosome, mRNA processing, mRNA splicing, via spliceosome, maintenance of gastrointestinal epithelium, negative regulation of transcription by RNA polymerase II, negative regulation of transforming growth factor beta receptor signaling pathway, neuron differentiation, protein-RNA complex assembly, spliceosomal snRNP assembly; MF: RNA binding, U2 snRNP binding, mRNA binding, protein binding, signaling receptor binding; CC: SMN complex, SMN-Sm protein complex, cytoplasm, cytosol, nucleus
Pathways: Adherens junctions interactions, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Downregulation of TGF-beta receptor signaling, Epithelial to mesenchymal transition in colorectal cancer, Positive Regulation of CDH1 Gene Transcription, RNA transport - Homo sapiens (human), Regulation of CDH1 Expression and Function, Regulation of CDH1 Gene Transcription, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Signal Transduction, Signaling by TGF-beta Receptor Complex, Signaling by TGFB family members, TGF-beta Signaling Pathway, TGF-beta receptor signaling, TGF-beta receptor signaling activates SMADs, TGF_beta_Receptor
UniProt: Q9Y3F4
Entrez ID: 11171
|
Does Knockout of FDXR in acute lymphoblastic leukemia cell line causally result in cell proliferation?
| 1
| 1,957
|
Knockout
|
FDXR
|
cell proliferation
|
acute lymphoblastic leukemia cell line
|
Gene: FDXR (ferredoxin reductase)
Type: protein-coding
Summary: This gene encodes a mitochondrial flavoprotein that initiates electron transport for cytochromes P450 receiving electrons from NADPH. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2012].
Gene Ontology: BP: cholesterol metabolic process, generation of precursor metabolites and energy, lipid metabolic process, steroid biosynthetic process, steroid metabolic process, ubiquinone biosynthetic process; MF: ferredoxin-NADP+ reductase activity, oxidoreductase activity; CC: membrane, mitochondrial inner membrane, mitochondrial matrix, mitochondrion
Pathways: Biological oxidations, Cytochrome P450 - arranged by substrate type, Defective CYP11A1 causes AICSR, Direct p53 effectors, Disease, Diseases of metabolism, Electron transport from NADPH to Ferredoxin, Endogenous sterols, Metabolic disorders of biological oxidation enzymes, Metabolism, Metabolism of lipids, Metabolism of steroid hormones, Metabolism of steroids, Mitochondrial iron-sulfur cluster biogenesis, Phase I - Functionalization of compounds, Pregnenolone biosynthesis, Validated transcriptional targets of TAp63 isoforms
UniProt: P22570
Entrez ID: 2232
|
Does Knockout of UQCRFS1 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 305
|
Knockout
|
UQCRFS1
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: UQCRFS1 (ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1)
Type: protein-coding
Summary: Predicted to enable oxidoreductase activity. Involved in mitochondrial respiratory chain complex III assembly and respiratory electron transport chain. Located in mitochondrion. Part of mitochondrial respiratory chain complex III and mitochondrial respiratory chain complex IV. Implicated in mitochondrial complex III deficiency. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: mitochondrial electron transport, ubiquinol to cytochrome c, mitochondrial respiratory chain complex III assembly, proton transmembrane transport, respiratory electron transport chain; MF: 2 iron, 2 sulfur cluster binding, iron-sulfur cluster binding, metal ion binding, oxidoreductase activity, protein binding, quinol-cytochrome-c reductase activity; CC: membrane, mitochondrial inner membrane, mitochondrial matrix, mitochondrial membrane, mitochondrion, respiratory chain complex III
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Cardiac muscle contraction - Homo sapiens (human), Complex III assembly, Diabetic cardiomyopathy - Homo sapiens (human), Electron Transport Chain (OXPHOS system in mitochondria), Huntington disease - Homo sapiens (human), Metabolism, Mitochondrial complex III assembly, Non-alcoholic fatty liver disease - Homo sapiens (human), Nonalcoholic fatty liver disease, Oxidative phosphorylation - Homo sapiens (human), Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Prion disease - Homo sapiens (human), Respiratory electron transport, Thermogenesis - Homo sapiens (human)
UniProt: P47985
Entrez ID: 7386
|
Does Knockout of FTH1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,789
|
Knockout
|
FTH1
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: FTH1 (ferritin heavy chain 1)
Type: protein-coding
Summary: This gene encodes the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative diseases. This gene has multiple pseudogenes. Several alternatively spliced transcript variants have been observed, but their biological validity has not been determined. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: immune response, intracellular iron ion homeostasis, iron ion transport, negative regulation of cell population proliferation, negative regulation of ferroptosis, negative regulation of fibroblast proliferation; MF: ferric iron binding, ferrous iron binding, ferroxidase activity, identical protein binding, iron ion binding, iron ion sequestering activity, metal ion binding, oxidoreductase activity, protein binding; CC: autolysosome, autophagosome, cytoplasm, cytoplasmic vesicle, cytosol, extracellular exosome, extracellular region, ferritin complex, ficolin-1-rich granule lumen, lysosome, nucleus, tertiary granule lumen
Pathways: Binding and Uptake of Ligands by Scavenger Receptors, Ferroptosis, Ferroptosis - Homo sapiens (human), Golgi Associated Vesicle Biogenesis, Immune System, Innate Immune System, Iron metabolism in placenta, Iron uptake and transport, Membrane Trafficking, Mineral absorption - Homo sapiens (human), NRF2 pathway, Necroptosis - Homo sapiens (human), Neutrophil degranulation, Nuclear Receptors Meta-Pathway, Scavenging by Class A Receptors, Transport of small molecules, Validated targets of C-MYC transcriptional repression, Vesicle-mediated transport, trans-Golgi Network Vesicle Budding
UniProt: P02794
Entrez ID: 2495
|
Does Knockout of CENPN in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 206
|
Knockout
|
CENPN
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: CENPN (centromere protein N)
Type: protein-coding
Summary: The protein encoded by this gene forms part of the nucleosome-associated complex and is important for kinetochore assembly. It is bound to kinetochores during S phase and G2 and recruits other proteins to the centromere. Pseudogenes of this gene are located on chromosome 2. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012].
Gene Ontology: BP: CENP-A containing chromatin assembly, chromosome segregation; CC: chromosome, chromosome, centromeric region, cytosol, inner kinetochore, kinetochore, nucleoplasm, nucleus
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Chromosome Maintenance, Deposition of new CENPA-containing nucleosomes at the centromere, EML4 and NUDC in mitotic spindle formation, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, Nucleosome assembly, RHO GTPase Effectors, RHO GTPases Activate Formins, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q96H22
Entrez ID: 55839
|
Does Knockout of RANBP17 in Cervical Adenocarcinoma Cell Line causally result in protein/peptide accumulation?
| 0
| 2,404
|
Knockout
|
RANBP17
|
protein/peptide accumulation
|
Cervical Adenocarcinoma Cell Line
|
Gene: RANBP17 (RAN binding protein 17)
Type: protein-coding
Summary: The transport of protein and large RNAs through the nuclear pore complexes (NPC) is an energy-dependent and regulated process. The import of proteins with a nuclear localization signal (NLS) is accomplished by recognition of one or more clusters of basic amino acids by the importin-alpha/beta complex; see MIM 600685 and MIM 602738. The small GTPase RAN (MIM 601179) plays a key role in NLS-dependent protein import. RAN-binding protein-17 is a member of the importin-beta superfamily of nuclear transport receptors.[supplied by OMIM, Jul 2002].
Gene Ontology: BP: intracellular protein transport, mRNA transport, nuclear transport, nucleocytoplasmic transport, protein export from nucleus, protein import into nucleus, protein transport; MF: GTP binding, nuclear export signal receptor activity, small GTPase binding; CC: cytoplasm, nuclear pore, nucleus
Pathways:
UniProt: Q9H2T7
Entrez ID: 64901
|
Does Knockout of MISP in Ewing's Sarcoma Cell Line causally result in cell proliferation?
| 0
| 763
|
Knockout
|
MISP
|
cell proliferation
|
Ewing's Sarcoma Cell Line
|
Gene: MISP (mitotic spindle positioning)
Type: protein-coding
Summary: The protein encoded by this gene is an actin-bundling protein involved in determining cell morphology and mitotic progression. The encoded protein is required for the proper positioning of the mitotic spindle. Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Feb 2016].
Gene Ontology: BP: cell division, cell migration, establishment of centrosome localization, establishment of mitotic spindle orientation, mitotic spindle assembly, organelle localization, regulation of protein localization to cell cortex; MF: actin binding, actin filament binding, protein binding; CC: actin filament, anchoring junction, cell cortex, cortical actin cytoskeleton, cytoplasm, cytoskeleton, focal adhesion, mitotic spindle astral microtubule end, plasma membrane, spindle pole centrosome
Pathways:
UniProt: Q8IVT2
Entrez ID: 126353
|
Does Knockout of UTP15 in Cancer Cell Line causally result in cell proliferation?
| 1
| 193
|
Knockout
|
UTP15
|
cell proliferation
|
Cancer Cell Line
|
Gene: UTP15 (UTP15 small subunit processome component)
Type: protein-coding
Summary: Enables RNA binding activity. Involved in positive regulation of rRNA processing and positive regulation of transcription by RNA polymerase I. Located in endoplasmic reticulum and fibrillar center. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: positive regulation of rRNA processing, positive regulation of transcription by RNA polymerase I, rRNA processing, ribosomal small subunit biogenesis, ribosome biogenesis; MF: RNA binding, protein binding; CC: cytoplasm, endoplasmic reticulum, fibrillar center, nucleolus, nucleoplasm, nucleus, small-subunit processome
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Ribosome biogenesis in eukaryotes - Homo sapiens (human), rRNA modification in the nucleus and cytosol, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q8TED0
Entrez ID: 84135
|
Does Knockout of EHD4 in Large Cell Lung Cancer Cell Line causally result in cell proliferation?
| 0
| 734
|
Knockout
|
EHD4
|
cell proliferation
|
Large Cell Lung Cancer Cell Line
|
Gene: EHD4 (EH domain containing 4)
Type: protein-coding
Summary: Enables cadherin binding activity. Involved in endocytic recycling and protein homooligomerization. Located in endoplasmic reticulum and recycling endosome membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cell migration involved in sprouting angiogenesis, cellular response to growth factor stimulus, cilium assembly, endocytic recycling, endocytosis, pinocytosis, protein homooligomerization, protein localization to plasma membrane, regulation of endocytosis; MF: ATP binding, GTP binding, cadherin binding, calcium ion binding, metal ion binding, nucleic acid binding, nucleotide binding, protein binding, protein-macromolecule adaptor activity; CC: adherens junction, anchoring junction, cytoplasm, early endosome, early endosome membrane, endocytic vesicle, endoplasmic reticulum, endosome, extracellular exosome, membrane, nucleus, perinuclear region of cytoplasm, plasma membrane, recycling endosome membrane
Pathways: Endocytosis - Homo sapiens (human), Neurotrophic factor-mediated Trk receptor signaling
UniProt: Q9H223
Entrez ID: 30844
|
Does Knockout of XPO5 in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 1,813
|
Knockout
|
XPO5
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: XPO5 (exportin 5)
Type: protein-coding
Summary: This gene encodes a member of the karyopherin family that is required for the transport of small RNAs and double-stranded RNA-binding proteins from the nucleus to the cytoplasm. The encoded protein translocates cargo through the nuclear pore complex in a RanGTP-dependent process. [provided by RefSeq, Aug 2011].
Gene Ontology: BP: RNA export from nucleus, intracellular protein transport, miRNA metabolic process, pre-miRNA export from nucleus, protein export from nucleus, protein transport, regulatory ncRNA-mediated gene silencing; MF: RISC complex binding, RNA binding, mRNA binding, nuclear export signal receptor activity, pre-miRNA binding, protein binding, small GTPase binding, tRNA binding; CC: RISC complex, RNA nuclear export complex, cytoplasm, cytosol, nucleoplasm, nucleus
Pathways: Gene Silencing by RNA, Gene expression (Transcription), MicroRNA (miRNA) biogenesis, RNA transport - Homo sapiens (human), exRNA mechanism of action and biogenesis, miRNA Biogenesis
UniProt: Q9HAV4
Entrez ID: 57510
|
Does Knockout of POLR1E in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,032
|
Knockout
|
POLR1E
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: POLR1E (RNA polymerase I subunit E)
Type: protein-coding
Summary: Predicted to enable DNA binding activity; DNA-directed 5'-3' RNA polymerase activity; and RNA polymerase I general transcription initiation factor binding activity. Involved in nucleolar large rRNA transcription by RNA polymerase I. Located in fibrillar center and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: DNA-templated transcription, RNA polymerase I preinitiation complex assembly, nucleolar large rRNA transcription by RNA polymerase I, transcription elongation by RNA polymerase I, transcription initiation at RNA polymerase I promoter; MF: DNA binding, RNA polymerase I general transcription initiation factor binding, protein binding; CC: DNA-directed RNA polymerase complex, RNA polymerase I complex, fibrillar center, nucleolus, nucleoplasm, nucleus
Pathways: B-WICH complex positively regulates rRNA expression, Epigenetic regulation of gene expression, Eukaryotic Transcription Initiation, Gene expression (Transcription), Negative epigenetic regulation of rRNA expression, NoRC negatively regulates rRNA expression, Positive epigenetic regulation of rRNA expression, Pyrimidine metabolism, RNA Polymerase I Promoter Clearance, RNA Polymerase I Promoter Escape, RNA Polymerase I Transcription, RNA Polymerase I Transcription Initiation, RNA Polymerase I Transcription Termination, RNA polymerase - Homo sapiens (human), TNFalpha
UniProt: Q9GZS1
Entrez ID: 64425
|
Does Knockout of PTS in Primary Effusion Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,061
|
Knockout
|
PTS
|
response to chemicals
|
Primary Effusion Lymphoma Cell Line
|
Gene: PTS (6-pyruvoyltetrahydropterin synthase)
Type: protein-coding
Summary: The enzyme encoded by this gene catalyzes the elimination of inorganic triphosphate from dihydroneopterin triphosphate, which is the second and irreversible step in the biosynthesis of tetrahydrobiopterin from GTP. Tetrahydrobiopterin, also known as BH(4), is an essential cofactor and regulator of various enzyme activities, including enzymes involved in serotonin biosynthesis and NO synthase activity. Mutations in this gene result in hyperphenylalaninemia. [provided by RefSeq, Oct 2008].
Gene Ontology: BP: amino acid metabolic process, central nervous system development, tetrahydrobiopterin biosynthetic process, tetrahydrobiopterin metabolic process; MF: 6-pyruvoyltetrahydropterin synthase activity, identical protein binding, lyase activity, metal ion binding, protein binding; CC: cytoplasm, cytosol, mitochondrion
Pathways: Dopa-responsive dystonia, Folate biosynthesis - Homo sapiens (human), Hyperphenylalaniemia due to guanosine triphosphate cyclohydrolase deficiency, Hyperphenylalaninemia due to 6-pyruvoyltetrahydropterin synthase deficiency (ptps), Hyperphenylalaninemia due to dhpr-deficiency, Metabolism, Metabolism of cofactors, Metabolism of vitamins and cofactors, Pterine Biosynthesis, Segawa syndrome, Sepiapterin reductase deficiency, Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation, tetrahydrobiopterin <i>de novo</i> biosynthesis
UniProt: Q03393
Entrez ID: 5805
|
Does Knockout of TMEM192 in Urinary Bladder Cancer Cell Line causally result in cell proliferation?
| 0
| 180
|
Knockout
|
TMEM192
|
cell proliferation
|
Urinary Bladder Cancer Cell Line
|
Gene: TMEM192 (transmembrane protein 192)
Type: protein-coding
Summary: Enables protein homodimerization activity. Located in several cellular components, including late endosome; lysosomal membrane; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: Golgi apparatus, endoplasmic reticulum, endosome, late endosome, lysosomal membrane, lysosome, membrane, nucleoplasm, nucleus, perinuclear region of cytoplasm, plasma membrane
Pathways:
UniProt: Q8IY95
Entrez ID: 201931
|
Does Knockout of RHOG in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals?
| 0
| 2,396
|
Knockout
|
RHOG
|
response to chemicals
|
Chronic Myelogenous Leukemia Cell Line
|
Gene: RHOG (ras homolog family member G)
Type: protein-coding
Summary: This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein facilitates translocation of a functional guanine nucleotide exchange factor (GEF) complex from the cytoplasm to the plasma membrane where ras-related C3 botulinum toxin substrate 1 is activated to promote lamellipodium formation and cell migration. Two related pseudogene have been identified on chromosomes 20 and X. [provided by RefSeq, Aug 2011].
Gene Ontology: BP: Rac protein signal transduction, Rho protein signal transduction, actin cytoskeleton organization, actin filament organization, activation of GTPase activity, cell chemotaxis, cortical cytoskeleton organization, establishment or maintenance of cell polarity, positive regulation of DNA-templated transcription, positive regulation of cell population proliferation, positive regulation of protein localization to plasma membrane, regulation of actin cytoskeleton organization, regulation of cell shape, regulation of postsynapse assembly, regulation of ruffle assembly, small GTPase-mediated signal transduction; MF: GTP binding, GTPase activity, nucleotide binding, protein binding, protein kinase binding; CC: cell projection, cytoplasmic vesicle, cytoskeleton, cytosol, endoplasmic reticulum membrane, extracellular exosome, focal adhesion, glutamatergic synapse, membrane, plasma membrane, postsynapse, secretory granule membrane
Pathways: Bacterial invasion of epithelial cells - Homo sapiens (human), Brain-derived neurotrophic factor (BDNF) signaling pathway, Constitutive Signaling by Aberrant PI3K in Cancer, Disease, Diseases of signal transduction by growth factor receptors and second messengers, GPVI-mediated activation cascade, Hemostasis, Immune System, Innate Immune System, Integrin-linked kinase signaling, Intracellular signaling by second messengers, Negative regulation of the PI3K/AKT network, Neurotrophic factor-mediated Trk receptor signaling, Neutrophil degranulation, PI3K/AKT Signaling in Cancer, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, PIP3 activates AKT signaling, Platelet activation, signaling and aggregation, RHO GTPase Effectors, RHO GTPase cycle, RHO GTPases activate KTN1, RHOG GTPase cycle, Salmonella infection - Homo sapiens (human), Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Yersinia infection - Homo sapiens (human)
UniProt: P84095
Entrez ID: 391
|
Does Knockout of CDC20 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 865
|
Knockout
|
CDC20
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: CDC20 (cell division cycle 20)
Type: protein-coding
Summary: CDC20 appears to act as a regulatory protein interacting with several other proteins at multiple points in the cell cycle. It is required for two microtubule-dependent processes, nuclear movement prior to anaphase and chromosome separation. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: G2/M transition of mitotic cell cycle, SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, anaphase-promoting complex-dependent catabolic process, cell differentiation, cell division, metaphase/anaphase transition of cell cycle, metaphase/anaphase transition of meiosis I, mitotic sister chromatid cohesion, mitotic spindle assembly, mitotic spindle assembly checkpoint signaling, nervous system development, positive regulation of anaphase-promoting complex-dependent catabolic process, positive regulation of cell population proliferation, positive regulation of mitotic metaphase/anaphase transition, positive regulation of synapse maturation, positive regulation of synaptic plasticity, positive regulation of ubiquitin protein ligase activity, protein deubiquitination, protein ubiquitination, regulation of dendrite development, regulation of meiotic cell cycle, regulation of meiotic nuclear division, regulation of mitotic cell cycle; MF: anaphase-promoting complex binding, histone deacetylase binding, protein binding, ubiquitin ligase activator activity, ubiquitin-like ligase-substrate adaptor activity, ubiquitin-protein transferase activator activity; CC: anaphase-promoting complex, centrosome, chromosome, chromosome, centromeric region, cytoplasm, cytoskeleton, cytosol, kinetochore, mitotic checkpoint complex, nucleoplasm, perinuclear region of cytoplasm, protein-containing complex, spindle, spindle pole
Pathways: APC-Cdc20 mediated degradation of Nek2A, APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Cyclin B, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Adaptive Immune System, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Antigen processing: Ubiquitination & Proteasome degradation, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle, Cell cycle - Homo sapiens (human), Class I MHC mediated antigen processing & presentation, Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, Deubiquitination, EML4 and NUDC in mitotic spindle formation, Human T-cell leukemia virus 1 infection - Homo sapiens (human), Immune System, Inactivation of APC/C via direct inhibition of the APC/C complex, Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components, M Phase, Metabolism of proteins, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, Oocyte meiosis - Homo sapiens (human), PLK1 signaling events, Phosphorylation of Emi1, Post-translational protein modification, RHO GTPase Effectors, RHO GTPases Activate Formins, Regulation of APC/C activators between G1/S and early anaphase, Regulation of mitotic cell cycle, Regulation of sister chromatid separation at the metaphase-anaphase transition, Resolution of Sister Chromatid Cohesion, SCF-beta-TrCP mediated degradation of Emi1, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Ub-specific processing proteases, Ubiquitin mediated proteolysis - Homo sapiens (human), Viral carcinogenesis - Homo sapiens (human)
UniProt: Q12834
Entrez ID: 991
|
Does Knockout of API5 in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 0
| 2,033
|
Knockout
|
API5
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: API5 (apoptosis inhibitor 5)
Type: protein-coding
Summary: This gene encodes an apoptosis inhibitory protein whose expression prevents apoptosis after growth factor deprivation. This protein suppresses the transcription factor E2F1-induced apoptosis and also interacts with, and negatively regulates Acinus, a nuclear factor involved in apoptotic DNA fragmentation. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011].
Gene Ontology: BP: apoptotic process, fibroblast apoptotic process, negative regulation of apoptotic process, negative regulation of fibroblast apoptotic process; MF: RNA binding, fibroblast growth factor binding, protein binding; CC: cytoplasm, membrane, nuclear speck, nucleus, spliceosomal complex
Pathways:
UniProt: Q9BZZ5
Entrez ID: 8539
|
Does Knockout of GTF3C3 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 149
|
Knockout
|
GTF3C3
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: GTF3C3 (general transcription factor IIIC subunit 3)
Type: protein-coding
Summary: The protein encoded by this gene is part of the TFIIIC2 complex, which binds to the promoters of small nuclear and cytoplasmic RNA genes in order to recruit RNA polymerase III. The TFIIIC2 complex is composed of six subunits. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].
Gene Ontology: BP: 5S class rRNA transcription by RNA polymerase III, tRNA transcription by RNA polymerase III, transcription by RNA polymerase III; MF: DNA binding, RNA polymerase III general transcription initiation factor activity, protein binding; CC: fibrillar center, nuclear membrane, nucleoplasm, nucleus, transcription factor TFIIIC complex
Pathways: Gene expression (Transcription), RNA Polymerase III Abortive And Retractive Initiation, RNA Polymerase III Transcription, RNA Polymerase III Transcription Initiation, RNA Polymerase III Transcription Initiation From Type 1 Promoter, RNA Polymerase III Transcription Initiation From Type 2 Promoter, rna polymerase iii transcription
UniProt: Q9Y5Q9
Entrez ID: 9330
|
Does Knockout of DNAJC5G in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 206
|
Knockout
|
DNAJC5G
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: DNAJC5G (DnaJ heat shock protein family (Hsp40) member C5 gamma)
Type: protein-coding
Summary: Predicted to be located in membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: cytoplasm, membrane
Pathways: Protein processing in endoplasmic reticulum - Homo sapiens (human)
UniProt: Q8N7S2
Entrez ID: 285126
|
Does Knockout of EMC7 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 839
|
Knockout
|
EMC7
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: EMC7 (ER membrane protein complex subunit 7)
Type: protein-coding
Summary: Contributes to membrane insertase activity. Involved in protein insertion into ER membrane by stop-transfer membrane-anchor sequence and tail-anchored membrane protein insertion into ER membrane. Is integral component of endoplasmic reticulum membrane. Part of EMC complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: protein insertion into ER membrane by stop-transfer membrane-anchor sequence, tail-anchored membrane protein insertion into ER membrane; MF: carbohydrate binding, membrane insertase activity, protein binding; CC: EMC complex, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways:
UniProt: Q9NPA0
Entrez ID: 56851
|
Does Knockout of LRRIQ1 in Prostate Cancer Cell Line causally result in cell proliferation?
| 0
| 843
|
Knockout
|
LRRIQ1
|
cell proliferation
|
Prostate Cancer Cell Line
|
Gene: LRRIQ1 (leucine rich repeats and IQ motif containing 1)
Type: protein-coding
Summary: Predicted to be involved in regulation of signal transduction. Predicted to be active in microtubule cytoskeleton. [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: apoptotic process, ectopic germ cell programmed cell death, gene expression, regulation of signal transduction, single fertilization
Pathways:
UniProt: Q96JM4
Entrez ID: 84125
|
Does Knockout of STK38L in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 865
|
Knockout
|
STK38L
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: STK38L (serine/threonine kinase 38 like)
Type: protein-coding
Summary: Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in intracellular signal transduction. Acts upstream of or within protein phosphorylation. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: intracellular signal transduction, negative regulation of autophagy, negative regulation of metabolic process, positive regulation of autophagy, protein phosphorylation, regulation of cellular component organization; MF: ATP binding, actin binding, kinase activity, magnesium ion binding, metal ion binding, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: actin cytoskeleton, cytoplasm, cytoskeleton, cytosol, membrane
Pathways: Hippo-Yap signaling pathway, Overview of leukocyte-intrinsic Hippo pathway functions
UniProt: Q9Y2H1
Entrez ID: 23012
|
Does Knockout of NDUFAB1 in Glioblastoma Cell Line causally result in cell proliferation?
| 1
| 519
|
Knockout
|
NDUFAB1
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: NDUFAB1 (NADH:ubiquinone oxidoreductase subunit AB1)
Type: protein-coding
Summary: Predicted to enable acyl binding activity; acyl carrier activity; and fatty acid binding activity. Involved in mitochondrial respiratory chain complex I assembly and protein lipoylation. Located in mitochondrion and nucleoplasm. Part of mitochondrial respiratory chain complex I. Colocalizes with mitochondrial large ribosomal subunit. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: [2Fe-2S] cluster assembly, aerobic respiration, fatty acid biosynthetic process, fatty acid metabolic process, iron-sulfur cluster assembly, lipid metabolic process, mitochondrial electron transport, NADH to ubiquinone, protein lipoylation, proton motive force-driven mitochondrial ATP synthesis; MF: acyl binding, acyl carrier activity, calcium ion binding, fatty acid binding, mitochondrial large ribosomal subunit binding, protein binding, structural molecule activity; CC: iron-sulfur cluster assembly complex, mitochondrial [2Fe-2S] assembly complex, mitochondrial inner membrane, mitochondrial matrix, mitochondrial membrane, mitochondrion, nucleoplasm, respiratory chain complex I
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Complex I biogenesis, Diabetic cardiomyopathy - Homo sapiens (human), Electron Transport Chain (OXPHOS system in mitochondria), Fatty acid metabolism, Huntington disease - Homo sapiens (human), Metabolism, Metabolism of lipids, Metabolism of proteins, Mitochondrial Fatty Acid Beta-Oxidation, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Non-alcoholic fatty liver disease - Homo sapiens (human), Nonalcoholic fatty liver disease, Oxidative phosphorylation, Oxidative phosphorylation - Homo sapiens (human), Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Post-translational protein modification, Prion disease - Homo sapiens (human), Protein lipoylation, Respiratory electron transport, Retrograde endocannabinoid signaling - Homo sapiens (human), Thermogenesis - Homo sapiens (human), Translation
UniProt: O14561
Entrez ID: 4706
|
Does Inhibition of WDR12 in Mammary Epithelial Cell Line causally result in cell proliferation?
| 1
| 2,248
|
Inhibition
|
WDR12
|
cell proliferation
|
Mammary Epithelial Cell Line
|
Gene: WDR12 (WD repeat domain 12)
Type: protein-coding
Summary: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein is highly similar to the mouse WD repeat domain 12 protein at the amino acid level. The protein encoded by this gene is a component of a nucleolar protein complex that affects maturation of the large ribosomal subunit.[provided by RefSeq, Dec 2008].
Gene Ontology: BP: Notch signaling pathway, maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing, regulation of cell cycle, ribosomal large subunit biogenesis, ribosome biogenesis; MF: protein binding, ribonucleoprotein complex binding; CC: PeBoW complex, nucleolus, nucleoplasm, nucleus, preribosome, large subunit precursor
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9GZL7
Entrez ID: 55759
|
Does Knockout of FAM163B in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 897
|
Knockout
|
FAM163B
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: FAM163B (family with sequence similarity 163 member B)
Type: protein-coding
Summary: Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways:
UniProt: P0C2L3
Entrez ID: 642968
|
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