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Does Activation of DYRK1A in T cell causally result in protein/peptide accumulation?
0
2,425
Activation
DYRK1A
protein/peptide accumulation
T cell
Gene: DYRK1A (dual specificity tyrosine phosphorylation regulated kinase 1A) Type: protein-coding Summary: This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leuc...
Does Knockout of PRAMEF6 in T-lymphoma cell line causally result in cell proliferation?
1
478
Knockout
PRAMEF6
cell proliferation
T-lymphoma cell line
Gene: PRAMEF6 (PRAME family member 6) Type: protein-coding Summary: Enables ubiquitin ligase-substrate adaptor activity. Involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Part of Cul2-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022] ...
Does Knockout of ABCB5 in Colorectal Cancer Cell Line causally result in cell proliferation?
0
783
Knockout
ABCB5
cell proliferation
Colorectal Cancer Cell Line
Gene: ABCB5 (ATP binding cassette subfamily B member 5) Type: protein-coding Summary: ABCB5 belongs to the ATP-binding cassette (ABC) transporter superfamily of integral membrane proteins. These proteins participate in ATP-dependent transmembrane transport of structurally diverse molecules ranging from ...
Does Knockout of PAX3 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
0
1,789
Knockout
PAX3
cell proliferation
Chronic Myeloid Leukemia Cell Line
Gene: PAX3 (paired box 3) Type: protein-coding Summary: This gene is a member of the paired box (PAX) family of transcription factors. Members of the PAX family typically contain a paired box domain and a paired-type homeodomain. These genes play critical roles during fetal development. Mutations in pai...
Does Knockout of ACTG1 in Cancer Cell Line causally result in cell proliferation?
1
948
Knockout
ACTG1
cell proliferation
Cancer Cell Line
Gene: ACTG1 (actin gamma 1) Type: protein-coding Summary: Actins are highly conserved proteins that are involved in various types of cell motility and in maintenance of the cytoskeleton. Three main groups of actin isoforms have been identified in vertebrate animals: alpha, beta, and gamma. The alpha act...
Does Knockout of TRNAU1AP in Endometrial Cancer Cell Line causally result in cell proliferation?
1
287
Knockout
TRNAU1AP
cell proliferation
Endometrial Cancer Cell Line
Gene: TRNAU1AP (tRNA selenocysteine 1 associated protein 1) Type: protein-coding Summary: Enables RNA binding activity. Predicted to be involved in selenocysteine incorporation. Predicted to be located in cytoplasm. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022] ...
Does Knockout of LYRM9 in Colonic Cancer Cell Line causally result in cell proliferation?
0
951
Knockout
LYRM9
cell proliferation
Colonic Cancer Cell Line
Gene: LYRM9 (LYR motif containing 9) Type: protein-coding Summary: Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025] Gene Ontology: Pathways: UniProt: A8MSI8 Entrez ID: 201229
Does Knockout of PAK1IP1 in Monocytic Leukemia Cell Line causally result in cell proliferation?
1
69
Knockout
PAK1IP1
cell proliferation
Monocytic Leukemia Cell Line
Gene: PAK1IP1 (PAK1 interacting protein 1) Type: protein-coding Summary: Involved in regulation of signal transduction by p53 class mediator and ribosomal large subunit biogenesis. Located in nucleolus. [provided by Alliance of Genome Resources, Apr 2022] Gene Ontology: BP: cell population prol...
Does Knockout of LARP1 in Ovarian Cancer Cell Line causally result in cell proliferation?
0
699
Knockout
LARP1
cell proliferation
Ovarian Cancer Cell Line
Gene: LARP1 (La ribonucleoprotein 1, translational regulator) Type: protein-coding Summary: Enables eukaryotic initiation factor 4E binding activity; nucleic acid binding activity; and ribosomal small subunit binding activity. Involved in several processes, including TORC1 signaling; cellular response t...
Does Knockout of MAP4K2 in Endometrial Cancer Cell Line causally result in cell proliferation?
0
758
Knockout
MAP4K2
cell proliferation
Endometrial Cancer Cell Line
Gene: MAP4K2 (mitogen-activated protein kinase kinase kinase kinase 2) Type: protein-coding Summary: The protein encoded by this gene is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells ...
Does Knockout of PSMD3 in Ewing's Sarcoma Cell Line causally result in cell proliferation?
1
763
Knockout
PSMD3
cell proliferation
Ewing's Sarcoma Cell Line
Gene: PSMD3 (proteasome 26S subunit, non-ATPase 3) Type: protein-coding Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings ar...
Does Knockout of RBL2 in Medulloblastoma Cell Line causally result in cell proliferation?
0
408
Knockout
RBL2
cell proliferation
Medulloblastoma Cell Line
Gene: RBL2 (RB transcriptional corepressor like 2) Type: protein-coding Summary: Enables promoter-specific chromatin binding activity. Involved in regulation of lipid kinase activity. Acts upstream of or within negative regulation of gene expression. Located in chromosome; cytosol; and nuclear lumen. [p...
Does Knockout of MAFK in Renal Cancer Cell Line causally result in cell proliferation?
0
319
Knockout
MAFK
cell proliferation
Renal Cancer Cell Line
Gene: MAFK (MAF bZIP transcription factor K) Type: protein-coding Summary: The developmentally regulated expression of the globin genes depends on upstream regulatory elements termed locus control regions (LCRs). LCRs are associated with powerful enhancer activity that is mediated by the transcription f...
Does Knockout of UNC80 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals?
0
1,352
Knockout
UNC80
response to chemicals
Cervical Adenocarcinoma Cell Line
Gene: UNC80 (unc-80 subunit of NALCN channel complex) Type: protein-coding Summary: The protein encoded by this gene is a component of a voltage-independent 'leak' ion-channel complex, in which it performs essential functions, such as serving as a bridge between two other components (sodium leak channel...
Does Knockout of KCNIP2 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
0
149
Knockout
KCNIP2
cell proliferation
Chronic Myeloid Leukemia Cell Line
Gene: KCNIP2 (potassium voltage-gated channel interacting protein 2) Type: protein-coding Summary: This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belongs to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family...
Does Knockout of SLC1A5 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals?
0
2,383
Knockout
SLC1A5
response to chemicals
Chronic Myelogenous Leukemia Cell Line
Gene: SLC1A5 (solute carrier family 1 member 5) Type: protein-coding Summary: The SLC1A5 gene encodes a sodium-dependent neutral amino acid transporter that can act as a receptor for RD114/type D retrovirus (Larriba et al., 2001 [PubMed 11781704]).[supplied by OMIM, Jan 2011]. Gene Ontology: BP...
Does Knockout of TMEM230 in Colorectal Cancer Cell Line causally result in cell proliferation?
0
783
Knockout
TMEM230
cell proliferation
Colorectal Cancer Cell Line
Gene: TMEM230 (transmembrane protein 230) Type: protein-coding Summary: This gene encodes a multi-pass transmembrane protein that belongs to the TMEM134/TMEM230 protein family. The encoded protein localizes to secretory and recycling vesicle in the neuron and may be involved in synaptic vesicles traffic...
Does Knockout of PSMD1 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
0
2,114
Knockout
PSMD1
cell proliferation
Primary Effusion Lymphoma Cell Line
Gene: PSMD1 (proteasome 26S subunit, non-ATPase 1) Type: protein-coding Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings ar...
Does Knockout of FAM186B in Renal Cancer Cell Line causally result in cell proliferation?
0
319
Knockout
FAM186B
cell proliferation
Renal Cancer Cell Line
Gene: FAM186B (family with sequence similarity 186 member B) Type: protein-coding Summary: This gene product is a member of the FAM186 family, however, its exact function is not known. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2009]. Gene ...
Does Knockout of SCARB1 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
0
1,576
Knockout
SCARB1
cell proliferation
Pre-B Acute Lymphoblastic Leukemia Cell Line
Gene: SCARB1 (scavenger receptor class B member 1) Type: protein-coding Summary: The protein encoded by this gene is a plasma membrane receptor for high density lipoprotein cholesterol (HDL). The encoded protein mediates cholesterol transfer to and from HDL. In addition, this protein is a receptor for h...
Does Activation of GUCA1C in Hepatoma Cell Line causally result in response to virus?
1
1,210
Activation
GUCA1C
response to virus
Hepatoma Cell Line
Gene: GUCA1C (guanylate cyclase activator 1C) Type: protein-coding Summary: Predicted to enable calcium ion binding activity and calcium sensitive guanylate cyclase activator activity. Predicted to be involved in signal transduction. Predicted to be located in photoreceptor disc membrane. [provided by A...
Does Knockout of THAP1 in Gastric Cancer Cell Line causally result in cell proliferation?
1
787
Knockout
THAP1
cell proliferation
Gastric Cancer Cell Line
Gene: THAP1 (THAP domain containing 1) Type: protein-coding Summary: The protein encoded by this gene contains a THAP domain, a conserved DNA-binding domain. This protein colocalizes with the apoptosis response protein PAWR/PAR-4 in promyelocytic leukemia (PML) nuclear bodies, and functions as a proapop...
Does Knockout of THSD1 in Lung Cancer Cell Line causally result in response to virus?
0
1,433
Knockout
THSD1
response to virus
Lung Cancer Cell Line
Gene: THSD1 (thrombospondin type 1 domain containing 1) Type: protein-coding Summary: The protein encoded by this gene contains a type 1 thrombospondin domain, which is found in a number of proteins involved in the complement pathway, as well as in extracellular matrix proteins. Alternatively spliced tr...
Does Knockout of CNOT7 in Cancer Cell Line causally result in cell proliferation?
0
193
Knockout
CNOT7
cell proliferation
Cancer Cell Line
Gene: CNOT7 (CCR4-NOT transcription complex subunit 7) Type: protein-coding Summary: The protein encoded by this gene binds to an anti-proliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of ...
Does Knockout of GSDMA in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
0
1,658
Knockout
GSDMA
cell proliferation
Colonic Adenocarcinoma Cell Line
Gene: GSDMA (gasdermin A) Type: protein-coding Summary: Predicted to enable phosphatidylinositol-4,5-bisphosphate binding activity; phosphatidylinositol-4-phosphate binding activity; and phosphatidylserine binding activity. Involved in apoptotic process. Located in perinuclear region of cytoplasm. [prov...
Does Activation of GMEB2 in Hepatoma Cell Line causally result in response to virus?
1
1,210
Activation
GMEB2
response to virus
Hepatoma Cell Line
Gene: GMEB2 (glucocorticoid modulatory element binding protein 2) Type: protein-coding Summary: This gene is a member of KDWK gene family. The product of this gene associates with GMEB1 protein, and the complex is essential for parvovirus DNA replication. Study of rat homolog implicates the role of this...
Does Knockout of MIR6874 in Monocytic Leukemia Cell Line causally result in response to chemicals?
0
1,978
Knockout
MIR6874
response to chemicals
Monocytic Leukemia Cell Line
Gene: MIR6874 (microRNA 6874) Type: ncRNA Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase...
Does Knockout of COPG1 in Gastric Cancer Cell Line causally result in cell proliferation?
1
787
Knockout
COPG1
cell proliferation
Gastric Cancer Cell Line
Gene: COPG1 (coat protein complex I subunit gamma 1) Type: protein-coding Summary: Predicted to enable structural molecule activity. Predicted to be involved in several processes, including Golgi vesicle transport; establishment of Golgi localization; and organelle transport along microtubule. Located i...
Does Knockout of MIR320D2 in Monocytic Leukemia Cell Line causally result in response to chemicals?
1
1,978
Knockout
MIR320D2
response to chemicals
Monocytic Leukemia Cell Line
Gene: MIR320D2 (microRNA 320d-2) Type: Summary: No summary available. Gene Ontology: Pathways: UniProt: Entrez ID:
Does Knockout of VPS39 in Medulloblastoma Cell Line causally result in cell proliferation?
0
1,813
Knockout
VPS39
cell proliferation
Medulloblastoma Cell Line
Gene: VPS39 (VPS39 subunit of HOPS complex) Type: protein-coding Summary: This gene encodes a protein that may promote clustering and fusion of late endosomes and lysosomes. The protein may also act as an adaptor protein that modulates the transforming growth factor-beta response by coupling the transfo...
Does Knockout of SIPA1L3 in Monocytic Leukemia Cell Line causally result in cell proliferation?
0
206
Knockout
SIPA1L3
cell proliferation
Monocytic Leukemia Cell Line
Gene: SIPA1L3 (signal induced proliferation associated 1 like 3) Type: protein-coding Summary: This gene belongs to the signal induced proliferation associated 1 family of genes, which encode GTPase-activating proteins specific for the GTP-binding protein Rap1. Rap1 has been implicated in regulation of ...
Does Knockout of TLR1 in Gastric Cancer Cell Line causally result in cell proliferation?
0
787
Knockout
TLR1
cell proliferation
Gastric Cancer Cell Line
Gene: TLR1 (toll like receptor 1) Type: protein-coding Summary: The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share stru...
Does Knockout of MYL3 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
0
1,339
Knockout
MYL3
response to chemicals
Retinal Pigment Epithelium Cell Line
Gene: MYL3 (myosin light chain 3) Type: protein-coding Summary: MYL3 encodes myosin light chain 3, an alkali light chain also referred to in the literature as both the ventricular isoform and the slow skeletal muscle isoform. Mutations in MYL3 have been identified as a cause of mid-left ventricular cham...
Does Knockout of ATIC in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
1
2,459
Knockout
ATIC
response to chemicals
Pancreatic Ductal Adenocarcinoma Cell Line
Gene: ATIC (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase) Type: protein-coding Summary: This gene encodes a bifunctional protein that catalyzes the last two steps of the de novo purine biosynthetic pathway. The N-terminal domain has phosphoribosylaminoimidazolecarbo...
Does Knockout of NUBPL in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals?
1
1,397
Knockout
NUBPL
response to chemicals
Chronic Myeloid Leukemia Cell Line
Gene: NUBPL (NUBP iron-sulfur cluster assembly factor, mitochondrial) Type: protein-coding Summary: This gene encodes a member of the Mrp/NBP35 ATP-binding proteins family. The encoded protein is required for the assembly of the respiratory chain NADH dehydrogenase (complex I), an oligomeric enzymatic c...
Does Inhibition of EIF6 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals?
1
1,184
Inhibition
EIF6
response to chemicals
Chronic Myeloid Leukemia Cell Line
Gene: EIF6 (eukaryotic translation initiation factor 6) Type: protein-coding Summary: Hemidesmosomes are structures which link the basal lamina to the intermediate filament cytoskeleton. An important functional component of hemidesmosomes is the integrin beta-4 subunit (ITGB4), a protein containing two ...
Does Knockout of FCGR1A in Endometrial Cancer Cell Line causally result in cell proliferation?
0
758
Knockout
FCGR1A
cell proliferation
Endometrial Cancer Cell Line
Gene: FCGR1A (Fc gamma receptor Ia) Type: protein-coding Summary: This gene encodes a protein that plays an important role in the immune response. This protein is a high-affinity Fc-gamma receptor. The gene is one of three related gene family members located on chromosome 1. [provided by RefSeq, Jul 200...
Does Knockout of KAZN in Astrocytoma Cell Line causally result in cell proliferation?
0
904
Knockout
KAZN
cell proliferation
Astrocytoma Cell Line
Gene: KAZN (kazrin, periplakin interacting protein) Type: protein-coding Summary: This gene encodes a protein that plays a role in desmosome assembly, cell adhesion, cytoskeletal organization, and epidermal differentiation. This protein co-localizes with desmoplakin and the cytolinker protein periplakin...
Does Knockout of SDHD in Cancer Cell Line causally result in cell proliferation?
1
193
Knockout
SDHD
cell proliferation
Cancer Cell Line
Gene: SDHD (succinate dehydrogenase complex subunit D) Type: protein-coding Summary: This gene encodes a member of complex II of the respiratory chain, which is responsible for the oxidation of succinate. The encoded protein is one of two integral membrane proteins anchoring the complex to the matrix si...
Does Knockout of MAP3K12 in Primary Effusion Lymphoma Cell Line causally result in response to chemicals?
0
1,061
Knockout
MAP3K12
response to chemicals
Primary Effusion Lymphoma Cell Line
Gene: MAP3K12 (mitogen-activated protein kinase kinase kinase 12) Type: protein-coding Summary: This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinas...
Does Knockout of DDOST in Gastric Cancer Cell Line causally result in cell proliferation?
1
230
Knockout
DDOST
cell proliferation
Gastric Cancer Cell Line
Gene: DDOST (dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit) Type: protein-coding Summary: This gene encodes a component of the oligosaccharyltransferase complex which catalyzes the transfer of high-mannose oligosaccharides to asparagine residues on nascent polypept...
Does Knockout of KRTAP12-2 in T-lymphoma cell line causally result in cell proliferation?
0
478
Knockout
KRTAP12-2
cell proliferation
T-lymphoma cell line
Gene: KRTAP12-2 (keratin associated protein 12-2) Type: protein-coding Summary: Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022] Gene Ontology: CC: cytosol, intermediate filament Pathways: Developmental Biology, Keratinization, Vitamin D Receptor...
Does Knockout of RUVBL2 in Colonic Cancer Cell Line causally result in cell proliferation?
1
815
Knockout
RUVBL2
cell proliferation
Colonic Cancer Cell Line
Gene: RUVBL2 (RuvB like AAA ATPase 2) Type: protein-coding Summary: This gene encodes the second human homologue of the bacterial RuvB gene. Bacterial RuvB protein is a DNA helicase essential for homologous recombination and DNA double-strand break repair. Functional analysis showed that this gene produ...
Does Knockout of MIR3936 in Hepatoma Cell Line causally result in response to virus?
0
2,447
Knockout
MIR3936
response to virus
Hepatoma Cell Line
Gene: MIR3936 (microRNA 3936) Type: ncRNA Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase...
Does Knockout of TBCC in Colonic Adenocarcinoma Cell Line causally result in response to chemicals?
1
1,736
Knockout
TBCC
response to chemicals
Colonic Adenocarcinoma Cell Line
Gene: TBCC (tubulin folding cofactor C) Type: protein-coding Summary: Cofactor C is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta...
Does Activation of KDM2A in T cell causally result in protein/peptide accumulation?
0
2,425
Activation
KDM2A
protein/peptide accumulation
T cell
Gene: KDM2A (lysine demethylase 2A) Type: protein-coding Summary: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1...
Does Activation of CLDN15 in T cell causally result in protein/peptide accumulation?
0
2,425
Activation
CLDN15
protein/peptide accumulation
T cell
Gene: CLDN15 (claudin 15) Type: protein-coding Summary: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the para...
Does Knockout of ANKRD44 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals?
0
1,397
Knockout
ANKRD44
response to chemicals
Chronic Myeloid Leukemia Cell Line
Gene: ANKRD44 (ankyrin repeat domain 44) Type: protein-coding Summary: ankyrin repeat domain 44 Gene Ontology: Pathways: UniProt: Q8N8A2 Entrez ID: 91526
Does Knockout of TOP1 in Monocytic Leukemia Cell Line causally result in cell proliferation?
1
80
Knockout
TOP1
cell proliferation
Monocytic Leukemia Cell Line
Gene: TOP1 (DNA topoisomerase I) Type: protein-coding Summary: This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass...
Does Knockout of KCNIP3 in Lung Cancer Cell Line causally result in response to virus?
1
1,433
Knockout
KCNIP3
response to virus
Lung Cancer Cell Line
Gene: KCNIP3 (potassium voltage-gated channel interacting protein 3) Type: protein-coding Summary: This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are small calc...
Does Knockout of APOBEC1 in Large Cell Lung Cancer Cell Line causally result in cell proliferation?
0
734
Knockout
APOBEC1
cell proliferation
Large Cell Lung Cancer Cell Line
Gene: APOBEC1 (apolipoprotein B mRNA editing enzyme catalytic subunit 1) Type: protein-coding Summary: This gene encodes a member of the cytidine deaminase enzyme family. The encoded protein forms a multiple-protein editing holoenzyme with APOBEC1 complementation factor (ACF) and APOBEC1 stimulating pro...
Does Knockout of OR10J4 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
0
1,246
Knockout
OR10J4
cell proliferation
Non-Small Cell Lung Cancer Cell Line
Gene: OR10J4 (olfactory receptor family 10 subfamily J member 4 (gene/pseudogene)) Type: protein-coding Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a larg...
Does Knockout of METTL3 in Colonic Cancer Cell Line causally result in cell proliferation?
1
951
Knockout
METTL3
cell proliferation
Colonic Cancer Cell Line
Gene: METTL3 (methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit) Type: protein-coding Summary: This gene encodes the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. This enzyme is involved in the posttranscriptional methylation of internal adenosine re...
Does Inhibition of BTN3A1 in Mammary Epithelial Cell Line causally result in cell proliferation?
0
2,248
Inhibition
BTN3A1
cell proliferation
Mammary Epithelial Cell Line
Gene: BTN3A1 (butyrophilin subfamily 3 member A1) Type: protein-coding Summary: The butyrophilin (BTN) genes are a group of major histocompatibility complex (MHC)-associated genes that encode type I membrane proteins with 2 extracellular immunoglobulin (Ig) domains and an intracellular B30.2 (PRYSPRY) d...
Does Knockout of EIF6 in Monocytic Leukemia Cell Line causally result in response to chemicals?
1
1,978
Knockout
EIF6
response to chemicals
Monocytic Leukemia Cell Line
Gene: EIF6 (eukaryotic translation initiation factor 6) Type: protein-coding Summary: Hemidesmosomes are structures which link the basal lamina to the intermediate filament cytoskeleton. An important functional component of hemidesmosomes is the integrin beta-4 subunit (ITGB4), a protein containing two ...
Does Knockout of RAB4A in Colonic Cancer Cell Line causally result in cell proliferation?
0
865
Knockout
RAB4A
cell proliferation
Colonic Cancer Cell Line
Gene: RAB4A (RAB4A, member RAS oncogene family) Type: protein-coding Summary: This gene is a member of the largest group in the Ras superfamily of small GTPases, which regulate membrane trafficking. The encoded protein is associated with early endosomes and is involved in their sorting and recycling. Th...
Does Knockout of CEACAM6 in Medulloblastoma Cell Line causally result in cell proliferation?
1
1,813
Knockout
CEACAM6
cell proliferation
Medulloblastoma Cell Line
Gene: CEACAM6 (CEA cell adhesion molecule 6) Type: protein-coding Summary: This gene encodes a protein that belongs to the carcinoembryonic antigen (CEA) family whose members are glycosyl phosphatidyl inositol (GPI) anchored cell surface glycoproteins. Members of this family play a role in cell adhesion...
Does Knockout of VCP in Breast Cancer Cell Line causally result in cell proliferation?
1
235
Knockout
VCP
cell proliferation
Breast Cancer Cell Line
Gene: VCP (valosin containing protein) Type: protein-coding Summary: This gene encodes a member of the AAA ATPase family of proteins. The encoded protein plays a role in protein degradation, intracellular membrane fusion, DNA repair and replication, regulation of the cell cycle, and activation of the NF...
Does Knockout of CD14 in Hepatoma Cell Line causally result in response to virus?
0
2,447
Knockout
CD14
response to virus
Hepatoma Cell Line
Gene: CD14 (CD14 molecule) Type: protein-coding Summary: The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with other proteins to mediate the innate immune response to bacterial lipopolysaccharide, and to viruses. This gene has...
Does Knockout of SMNDC1 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
1
334
Knockout
SMNDC1
cell proliferation
Esophageal Squamous Cell Carcinoma Cell Line
Gene: SMNDC1 (survival motor neuron domain containing 1) Type: protein-coding Summary: This gene is a paralog of SMN1 gene, which encodes the survival motor neuron protein, mutations in which are cause of autosomal recessive proximal spinal muscular atrophy. The protein encoded by this gene is a nuclear...
Does Knockout of CLDN19 in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
0
387
Knockout
CLDN19
cell proliferation
Lung Adenocarcinoma Cell Line
Gene: CLDN19 (claudin 19) Type: protein-coding Summary: The product of this gene belongs to the claudin family. It plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Defects in this gene are the cause of hypomagnesem...
Does Knockout of ZNF250 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals?
0
1,352
Knockout
ZNF250
response to chemicals
Cervical Adenocarcinoma Cell Line
Gene: ZNF250 (zinc finger protein 250) Type: protein-coding Summary: Enables identical protein binding activity and sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Allian...
Does Knockout of CPSF3 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
1
2,114
Knockout
CPSF3
cell proliferation
Primary Effusion Lymphoma Cell Line
Gene: CPSF3 (cleavage and polyadenylation specific factor 3) Type: protein-coding Summary: This gene encodes a member of the metallo-beta-lactamase family. The encoded protein is a 73kDa subunit of the cleavage and polyadenylation specificity factor and functions as an endonuclease that recognizes the p...
Does Knockout of MED23 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
1
1,246
Knockout
MED23
cell proliferation
Non-Small Cell Lung Cancer Cell Line
Gene: MED23 (mediator complex subunit 23) Type: protein-coding Summary: The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA pol...
Does Knockout of WDR70 in Medulloblastoma Cell Line causally result in cell proliferation?
1
408
Knockout
WDR70
cell proliferation
Medulloblastoma Cell Line
Gene: WDR70 (WD repeat domain 70) Type: protein-coding Summary: Enables enzyme binding activity. Predicted to be involved in regulation of DNA double-strand break processing and regulation of histone H2B conserved C-terminal lysine ubiquitination. Predicted to be active in nucleus and site of double-str...
Does Knockout of GRIN3A in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
0
1,658
Knockout
GRIN3A
cell proliferation
Colonic Adenocarcinoma Cell Line
Gene: GRIN3A (glutamate ionotropic receptor NMDA type subunit 3A) Type: protein-coding Summary: This gene encodes a subunit of the N-methyl-D-aspartate (NMDA) receptors, which belong to the superfamily of glutamate-regulated ion channels, and function in physiological and pathological processes in the c...
Does Knockout of CYB5R2 in Bladder Carcinoma causally result in cell proliferation?
0
489
Knockout
CYB5R2
cell proliferation
Bladder Carcinoma
Gene: CYB5R2 (cytochrome b5 reductase 2) Type: protein-coding Summary: The protein encoded by this gene belongs to the flavoprotein pyridine nucleotide cytochrome reductase family of proteins. Cytochrome b-type NAD(P)H oxidoreductases are implicated in many processes including cholesterol biosynthesis, ...
Does Knockout of OSTN in Melanoma Cell Line causally result in response to chemicals?
1
1,940
Knockout
OSTN
response to chemicals
Melanoma Cell Line
Gene: OSTN (osteocrin) Type: protein-coding Summary: Predicted to enable signaling receptor binding activity. Involved in negative regulation of dendrite extension. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022] Gene Ontology: BP: bone growth...
Does Knockout of AP1M2 in Endometrial Cancer Cell Line causally result in cell proliferation?
0
758
Knockout
AP1M2
cell proliferation
Endometrial Cancer Cell Line
Gene: AP1M2 (adaptor related protein complex 1 subunit mu 2) Type: protein-coding Summary: This gene encodes a subunit of the heterotetrameric adaptor-related protein comlex 1 (AP-1), which belongs to the adaptor complexes medium subunits family. This protein is capable of interacting with tyrosine-base...
Does Knockout of DEFB124 in Colorectal Cancer Cell Line causally result in response to chemicals?
0
1,414
Knockout
DEFB124
response to chemicals
Colorectal Cancer Cell Line
Gene: DEFB124 (defensin beta 124) Type: protein-coding Summary: Defensins are cysteine-rich cationic polypeptides that are important in the host immunologic response to invading microorganisms. This antimicrobial protein is secreted and is a member of the beta defensin protein family. Beta defensin gene...
Does Knockout of PDCD11 in Monocytic Leukemia Cell Line causally result in cell proliferation?
1
69
Knockout
PDCD11
cell proliferation
Monocytic Leukemia Cell Line
Gene: PDCD11 (programmed cell death 11) Type: protein-coding Summary: PDCD11 is a NF-kappa-B (NFKB1; 164011)-binding protein that colocalizes with U3 RNA (MIM 180710) in the nucleolus and is required for rRNA maturation and generation of 18S rRNA (Sweet et al., 2003 [PubMed 14624448]; Sweet et al., 2008...
Does Knockout of EIF1AX in Monocytic Leukemia Cell Line causally result in cell proliferation?
1
80
Knockout
EIF1AX
cell proliferation
Monocytic Leukemia Cell Line
Gene: EIF1AX (eukaryotic translation initiation factor 1A X-linked) Type: protein-coding Summary: This gene encodes an essential eukaryotic translation initiation factor. The protein is required for the binding of the 43S complex (a 40S subunit, eIF2/GTP/Met-tRNAi and eIF3) to the 5' end of capped RNA. ...
Does Knockout of VPS18 in Monocytic Leukemia Cell Line causally result in cell proliferation?
1
206
Knockout
VPS18
cell proliferation
Monocytic Leukemia Cell Line
Gene: VPS18 (VPS18 core subunit of CORVET and HOPS complexes) Type: protein-coding Summary: Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) ge...
Does Knockout of DOK2 in Melanoma Cell Line causally result in response to chemicals?
1
95
Knockout
DOK2
response to chemicals
Melanoma Cell Line
Gene: DOK2 (docking protein 2) Type: protein-coding Summary: The protein encoded by this gene is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeri...
Does Knockout of NPLOC4 in acute lymphoblastic leukemia cell line causally result in cell proliferation?
1
1,957
Knockout
NPLOC4
cell proliferation
acute lymphoblastic leukemia cell line
Gene: NPLOC4 (NPL4 homolog, ubiquitin recognition factor) Type: protein-coding Summary: Predicted to enable ATPase binding activity; ubiquitin binding activity; and ubiquitin protein ligase binding activity. Predicted to contribute to K48-linked polyubiquitin modification-dependent protein binding activ...
Does Knockout of FDX1 in Hepatoma Cell Line causally result in response to virus?
1
2,437
Knockout
FDX1
response to virus
Hepatoma Cell Line
Gene: FDX1 (ferredoxin 1) Type: protein-coding Summary: This gene encodes a small iron-sulfur protein that transfers electrons from NADPH through ferredoxin reductase to mitochondrial cytochrome P450, involved in steroid, vitamin D, and bile acid metabolism. Pseudogenes of this functional gene are found...
Does Knockout of STRAP in Monocytic Leukemia Cell Line causally result in cell proliferation?
1
69
Knockout
STRAP
cell proliferation
Monocytic Leukemia Cell Line
Gene: STRAP (serine/threonine kinase receptor associated protein) Type: protein-coding Summary: Enables RNA binding activity. Involved in maintenance of gastrointestinal epithelium; negative regulation of transforming growth factor beta receptor signaling pathway; and spliceosomal snRNP assembly. Locate...
Does Knockout of FDXR in acute lymphoblastic leukemia cell line causally result in cell proliferation?
1
1,957
Knockout
FDXR
cell proliferation
acute lymphoblastic leukemia cell line
Gene: FDXR (ferredoxin reductase) Type: protein-coding Summary: This gene encodes a mitochondrial flavoprotein that initiates electron transport for cytochromes P450 receiving electrons from NADPH. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr...
Does Knockout of UQCRFS1 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
1
305
Knockout
UQCRFS1
cell proliferation
Lung Squamous Cell Carcinoma Cell Line
Gene: UQCRFS1 (ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1) Type: protein-coding Summary: Predicted to enable oxidoreductase activity. Involved in mitochondrial respiratory chain complex III assembly and respiratory electron transport chain. Located in mitochondrion. Part of mitoc...
Does Knockout of FTH1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
0
1,789
Knockout
FTH1
cell proliferation
Chronic Myeloid Leukemia Cell Line
Gene: FTH1 (ferritin heavy chain 1) Type: protein-coding Summary: This gene encodes the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition m...
Does Knockout of CENPN in Monocytic Leukemia Cell Line causally result in cell proliferation?
1
206
Knockout
CENPN
cell proliferation
Monocytic Leukemia Cell Line
Gene: CENPN (centromere protein N) Type: protein-coding Summary: The protein encoded by this gene forms part of the nucleosome-associated complex and is important for kinetochore assembly. It is bound to kinetochores during S phase and G2 and recruits other proteins to the centromere. Pseudogenes of thi...
Does Knockout of RANBP17 in Cervical Adenocarcinoma Cell Line causally result in protein/peptide accumulation?
0
2,404
Knockout
RANBP17
protein/peptide accumulation
Cervical Adenocarcinoma Cell Line
Gene: RANBP17 (RAN binding protein 17) Type: protein-coding Summary: The transport of protein and large RNAs through the nuclear pore complexes (NPC) is an energy-dependent and regulated process. The import of proteins with a nuclear localization signal (NLS) is accomplished by recognition of one or mor...
Does Knockout of MISP in Ewing's Sarcoma Cell Line causally result in cell proliferation?
0
763
Knockout
MISP
cell proliferation
Ewing's Sarcoma Cell Line
Gene: MISP (mitotic spindle positioning) Type: protein-coding Summary: The protein encoded by this gene is an actin-bundling protein involved in determining cell morphology and mitotic progression. The encoded protein is required for the proper positioning of the mitotic spindle. Two transcript variants...
Does Knockout of UTP15 in Cancer Cell Line causally result in cell proliferation?
1
193
Knockout
UTP15
cell proliferation
Cancer Cell Line
Gene: UTP15 (UTP15 small subunit processome component) Type: protein-coding Summary: Enables RNA binding activity. Involved in positive regulation of rRNA processing and positive regulation of transcription by RNA polymerase I. Located in endoplasmic reticulum and fibrillar center. [provided by Alliance...
Does Knockout of EHD4 in Large Cell Lung Cancer Cell Line causally result in cell proliferation?
0
734
Knockout
EHD4
cell proliferation
Large Cell Lung Cancer Cell Line
Gene: EHD4 (EH domain containing 4) Type: protein-coding Summary: Enables cadherin binding activity. Involved in endocytic recycling and protein homooligomerization. Located in endoplasmic reticulum and recycling endosome membrane. [provided by Alliance of Genome Resources, Apr 2022] Gene Ontol...
Does Knockout of XPO5 in Medulloblastoma Cell Line causally result in cell proliferation?
1
1,813
Knockout
XPO5
cell proliferation
Medulloblastoma Cell Line
Gene: XPO5 (exportin 5) Type: protein-coding Summary: This gene encodes a member of the karyopherin family that is required for the transport of small RNAs and double-stranded RNA-binding proteins from the nucleus to the cytoplasm. The encoded protein translocates cargo through the nuclear pore complex ...
Does Knockout of POLR1E in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
1
1,032
Knockout
POLR1E
cell proliferation
Chronic Myeloid Leukemia Cell Line
Gene: POLR1E (RNA polymerase I subunit E) Type: protein-coding Summary: Predicted to enable DNA binding activity; DNA-directed 5'-3' RNA polymerase activity; and RNA polymerase I general transcription initiation factor binding activity. Involved in nucleolar large rRNA transcription by RNA polymerase I....
Does Knockout of PTS in Primary Effusion Lymphoma Cell Line causally result in response to chemicals?
0
1,061
Knockout
PTS
response to chemicals
Primary Effusion Lymphoma Cell Line
Gene: PTS (6-pyruvoyltetrahydropterin synthase) Type: protein-coding Summary: The enzyme encoded by this gene catalyzes the elimination of inorganic triphosphate from dihydroneopterin triphosphate, which is the second and irreversible step in the biosynthesis of tetrahydrobiopterin from GTP. Tetrahydrob...
Does Knockout of TMEM192 in Urinary Bladder Cancer Cell Line causally result in cell proliferation?
0
180
Knockout
TMEM192
cell proliferation
Urinary Bladder Cancer Cell Line
Gene: TMEM192 (transmembrane protein 192) Type: protein-coding Summary: Enables protein homodimerization activity. Located in several cellular components, including late endosome; lysosomal membrane; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] Gene ...
Does Knockout of RHOG in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals?
0
2,396
Knockout
RHOG
response to chemicals
Chronic Myelogenous Leukemia Cell Line
Gene: RHOG (ras homolog family member G) Type: protein-coding Summary: This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization...
Does Knockout of CDC20 in Colonic Cancer Cell Line causally result in cell proliferation?
1
865
Knockout
CDC20
cell proliferation
Colonic Cancer Cell Line
Gene: CDC20 (cell division cycle 20) Type: protein-coding Summary: CDC20 appears to act as a regulatory protein interacting with several other proteins at multiple points in the cell cycle. It is required for two microtubule-dependent processes, nuclear movement prior to anaphase and chromosome separati...
Does Knockout of API5 in Cervical Adenocarcinoma Cell Line causally result in response to virus?
0
2,033
Knockout
API5
response to virus
Cervical Adenocarcinoma Cell Line
Gene: API5 (apoptosis inhibitor 5) Type: protein-coding Summary: This gene encodes an apoptosis inhibitory protein whose expression prevents apoptosis after growth factor deprivation. This protein suppresses the transcription factor E2F1-induced apoptosis and also interacts with, and negatively regulate...
Does Knockout of GTF3C3 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
1
149
Knockout
GTF3C3
cell proliferation
Chronic Myeloid Leukemia Cell Line
Gene: GTF3C3 (general transcription factor IIIC subunit 3) Type: protein-coding Summary: The protein encoded by this gene is part of the TFIIIC2 complex, which binds to the promoters of small nuclear and cytoplasmic RNA genes in order to recruit RNA polymerase III. The TFIIIC2 complex is composed of six...
Does Knockout of DNAJC5G in Monocytic Leukemia Cell Line causally result in cell proliferation?
0
206
Knockout
DNAJC5G
cell proliferation
Monocytic Leukemia Cell Line
Gene: DNAJC5G (DnaJ heat shock protein family (Hsp40) member C5 gamma) Type: protein-coding Summary: Predicted to be located in membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Gene Ontology: CC: cytoplasm, membrane Pathways...
Does Knockout of EMC7 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
0
839
Knockout
EMC7
cell proliferation
Lung Squamous Cell Carcinoma Cell Line
Gene: EMC7 (ER membrane protein complex subunit 7) Type: protein-coding Summary: Contributes to membrane insertase activity. Involved in protein insertion into ER membrane by stop-transfer membrane-anchor sequence and tail-anchored membrane protein insertion into ER membrane. Is integral component of en...
Does Knockout of LRRIQ1 in Prostate Cancer Cell Line causally result in cell proliferation?
0
843
Knockout
LRRIQ1
cell proliferation
Prostate Cancer Cell Line
Gene: LRRIQ1 (leucine rich repeats and IQ motif containing 1) Type: protein-coding Summary: Predicted to be involved in regulation of signal transduction. Predicted to be active in microtubule cytoskeleton. [provided by Alliance of Genome Resources, Apr 2025] Gene Ontology: BP: apoptotic proces...
Does Knockout of STK38L in Colonic Cancer Cell Line causally result in cell proliferation?
0
865
Knockout
STK38L
cell proliferation
Colonic Cancer Cell Line
Gene: STK38L (serine/threonine kinase 38 like) Type: protein-coding Summary: Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in intracellular signal transduction. Acts upstream of or within protein phosphorylation. Located in cytosol. ...
Does Knockout of NDUFAB1 in Glioblastoma Cell Line causally result in cell proliferation?
1
519
Knockout
NDUFAB1
cell proliferation
Glioblastoma Cell Line
Gene: NDUFAB1 (NADH:ubiquinone oxidoreductase subunit AB1) Type: protein-coding Summary: Predicted to enable acyl binding activity; acyl carrier activity; and fatty acid binding activity. Involved in mitochondrial respiratory chain complex I assembly and protein lipoylation. Located in mitochondrion and...
Does Inhibition of WDR12 in Mammary Epithelial Cell Line causally result in cell proliferation?
1
2,248
Inhibition
WDR12
cell proliferation
Mammary Epithelial Cell Line
Gene: WDR12 (WD repeat domain 12) Type: protein-coding Summary: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or m...
Does Knockout of FAM163B in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
0
897
Knockout
FAM163B
cell proliferation
Lung Adenocarcinoma Cell Line
Gene: FAM163B (family with sequence similarity 163 member B) Type: protein-coding Summary: Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022] Gene Ontology: Pathways: UniProt: P0C2L3 Entrez ID: 642968