prompt string | hit int64 | screen_id int64 | crispr_strategy string | gene string | phenotype string | cell_type string | gene_context string |
|---|---|---|---|---|---|---|---|
Does Knockout of OR10K1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 1,658 | Knockout | OR10K1 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: OR10K1 (olfactory receptor family 10 subfamily K member 1)
Type: protein-coding
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-prot... |
Does Knockout of FIG4 in Melanoma Cell Line causally result in cell proliferation? | 1 | 527 | Knockout | FIG4 | cell proliferation | Melanoma Cell Line | Gene: FIG4 (FIG4 phosphoinositide 5-phosphatase)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the SAC domain-containing protein gene family. The SAC domain, approximately 400 amino acids in length and consisting of seven conserved motifs, has been shown to possess phosphoino... |
Does Knockout of SRP68 in Ovarian Cancer Cell Line causally result in cell proliferation? | 1 | 699 | Knockout | SRP68 | cell proliferation | Ovarian Cancer Cell Line | Gene: SRP68 (signal recognition particle 68)
Type: protein-coding
Summary: This gene encodes a subunit of the signal recognition particle (SRP). The SRP is a ribonucleoprotein complex that transports secreted and membrane proteins to the endoplasmic reticulum for processing. The complex includes a 7S RN... |
Does Knockout of MIR15B in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals? | 0 | 2,383 | Knockout | MIR15B | response to chemicals | Chronic Myelogenous Leukemia Cell Line | Gene: MIR15B (microRNA 15b)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase I... |
Does Knockout of TSPY3 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 0 | 1,246 | Knockout | TSPY3 | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: TSPY3 (testis specific protein Y-linked 3)
Type: protein-coding
Summary: Predicted to enable chromatin binding activity and histone binding activity. Predicted to be involved in sex differentiation. Predicted to be located in cytoplasm. Predicted to be active in chromatin and nucleus. [provided by... |
Does Knockout of SP2 in Melanoma Cell Line causally result in cell proliferation? | 1 | 527 | Knockout | SP2 | cell proliferation | Melanoma Cell Line | Gene: SP2 (Sp2 transcription factor)
Type: protein-coding
Summary: This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc fin... |
Does Knockout of IPO9 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 1,352 | Knockout | IPO9 | response to chemicals | Cervical Adenocarcinoma Cell Line | Gene: IPO9 (importin 9)
Type: protein-coding
Summary: Enables nuclear import signal receptor activity. Involved in protein import into nucleus. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: intracellular protein transport, proteasomal protein cata... |
Does Knockout of RENBP in Monocytic Leukemia Cell Line causally result in RNA accumulation? | 0 | 1,968 | Knockout | RENBP | RNA accumulation | Monocytic Leukemia Cell Line | Gene: RENBP (renin binding protein)
Type: protein-coding
Summary: The gene product inhibits renin activity by forming a dimer with renin, a complex known as high molecular weight renin. The encoded protein contains a leucine zipper domain, which is essential for its dimerization with renin. The gene pro... |
Does Knockout of DMAP1 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals? | 1 | 1,736 | Knockout | DMAP1 | response to chemicals | Colonic Adenocarcinoma Cell Line | Gene: DMAP1 (DNA methyltransferase 1 associated protein 1)
Type: protein-coding
Summary: This gene encodes a subunit of several, distinct complexes involved in the repression or activation of transcription. The encoded protein can independently repress transcription and is targeted to replication foci t... |
Does Activation of TP53AIP1 in Hepatoma Cell Line causally result in response to virus? | 0 | 1,210 | Activation | TP53AIP1 | response to virus | Hepatoma Cell Line | Gene: TP53AIP1 (tumor protein p53 regulated apoptosis inducing protein 1)
Type: protein-coding
Summary: This gene is specifically expressed in the thymus, and encodes a protein that is localized to the mitochondrion. The expression of this gene is inducible by p53, and it is thought to play an important... |
Does Knockout of COX17 in Cervical Adenocarcinoma Cell Line causally result in response to virus? | 0 | 2,033 | Knockout | COX17 | response to virus | Cervical Adenocarcinoma Cell Line | Gene: COX17 (cytochrome c oxidase copper chaperone COX17)
Type: protein-coding
Summary: Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 ... |
Does Knockout of ZSCAN5A in Cancer Cell Line causally result in cell proliferation? | 0 | 1,308 | Knockout | ZSCAN5A | cell proliferation | Cancer Cell Line | Gene: ZSCAN5A (zinc finger and SCAN domain containing 5A)
Type: protein-coding
Summary: Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resour... |
Does Knockout of PSMD11 in Gastric Cancer Cell Line causally result in cell proliferation? | 1 | 230 | Knockout | PSMD11 | cell proliferation | Gastric Cancer Cell Line | Gene: PSMD11 (proteasome 26S subunit, non-ATPase 11)
Type: protein-coding
Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings ... |
Does Knockout of RABGGTB in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 427 | Knockout | RABGGTB | cell proliferation | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: RABGGTB (Rab geranylgeranyltransferase subunit beta)
Type: protein-coding
Summary: This gene encodes the beta-subunit of the enzyme Rab geranylgeranyl-transferase (RabGGTase), which belongs to the protein prenyltransferase family. RabGGTase catalyzes the post-translational addition of geranylgeran... |
Does Knockout of AHCTF1 in Glioblastoma Cell Line causally result in cell proliferation? | 1 | 906 | Knockout | AHCTF1 | cell proliferation | Glioblastoma Cell Line | Gene: AHCTF1 (AT-hook containing transcription factor 1)
Type: protein-coding
Summary: Predicted to enable DNA binding activity. Involved in nuclear pore complex assembly and regulation of cytokinesis. Located in nuclear membrane. Colocalizes with chromatin; kinetochore; and nuclear pore outer ring. [pr... |
Does Knockout of HES2 in Ovarian Cancer Cell Line causally result in cell proliferation? | 0 | 699 | Knockout | HES2 | cell proliferation | Ovarian Cancer Cell Line | Gene: HES2 (hes family bHLH transcription factor 2)
Type: protein-coding
Summary: Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in anterior/posterior pattern specification; regulation of neurogenesis; and regulation of transcription by RNA polymerase II. Predic... |
Does Knockout of OR4E2 in Colonic Adenocarcinoma Cell Line causally result in response to bacteria? | 0 | 1,480 | Knockout | OR4E2 | response to bacteria | Colonic Adenocarcinoma Cell Line | Gene: OR4E2 (olfactory receptor family 4 subfamily E member 2)
Type: protein-coding
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protei... |
Does Knockout of ARMC5 in Lung Cancer Cell Line causally result in response to radiation? | 1 | 1,952 | Knockout | ARMC5 | response to radiation | Lung Cancer Cell Line | Gene: ARMC5 (armadillo repeat containing 5)
Type: protein-coding
Summary: This gene encodes a member of the ARM (armadillo/beta-catenin-like repeat) superfamily. The ARM repeat is a tandemly repeated sequence motif with approximately 40 amino acid long. This repeat is implicated in mediating protein-pro... |
Does Knockout of PISD in acute lymphoblastic leukemia cell line causally result in cell proliferation? | 1 | 1,957 | Knockout | PISD | cell proliferation | acute lymphoblastic leukemia cell line | Gene: PISD (phosphatidylserine decarboxylase)
Type: protein-coding
Summary: The protein encoded by this gene catalyzes the conversion of phosphatidylserine to phosphatidylethanolamine in the inner mitochondrial membrane. The encoded protein is active in phospholipid metabolism and interorganelle traffic... |
Does Activation of FGGY in T cell causally result in protein/peptide accumulation? | 0 | 2,426 | Activation | FGGY | protein/peptide accumulation | T cell | Gene: FGGY (FGGY carbohydrate kinase domain containing)
Type: protein-coding
Summary: This gene encodes a protein that phosphorylates carbohydrates such as ribulose, ribitol, and L-arabinitol. Genome-wide association studies in some populations have found an association between polymorphisms in this gen... |
Does Knockout of SUGP1 in Bladder Carcinoma causally result in cell proliferation? | 1 | 489 | Knockout | SUGP1 | cell proliferation | Bladder Carcinoma | Gene: SUGP1 (SURP and G-patch domain containing 1)
Type: protein-coding
Summary: SF4 is a member of the SURP family of splicing factors.[supplied by OMIM, Sep 2003].
Gene Ontology: BP: RNA processing, RNA splicing, mRNA processing; MF: RNA binding, mRNA binding, nucleic acid binding, protein bi... |
Does Knockout of KLC4 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 305 | Knockout | KLC4 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: KLC4 (kinesin light chain 4)
Type: protein-coding
Summary: Predicted to be located in cytoplasm and microtubule. Predicted to be part of kinesin complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: kinesin binding, protein binding; CC: cytoplasm, cytoskeleton, ... |
Does Knockout of SLC12A5 in Endometrial Cancer Cell Line causally result in cell proliferation? | 0 | 758 | Knockout | SLC12A5 | cell proliferation | Endometrial Cancer Cell Line | Gene: SLC12A5 (solute carrier family 12 member 5)
Type: protein-coding
Summary: K-Cl cotransporters are proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The protein encoded by this gene is an integral membrane K-Cl cotransporter that can function... |
Does Activation of PIK3C2A in Hepatoma Cell Line causally result in response to virus? | 1 | 1,210 | Activation | PIK3C2A | response to virus | Hepatoma Cell Line | Gene: PIK3C2A (phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transform... |
Does Knockout of CADPS2 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation? | 0 | 1,576 | Knockout | CADPS2 | cell proliferation | Pre-B Acute Lymphoblastic Leukemia Cell Line | Gene: CADPS2 (calcium dependent secretion activator 2)
Type: protein-coding
Summary: This gene encodes a member of the calcium-dependent activator of secretion (CAPS) protein family, which are calcium binding proteins that regulate the exocytosis of synaptic and dense-core vesicles in neurons and neuroe... |
Does Knockout of NUP85 in Bladder Carcinoma causally result in cell proliferation? | 1 | 489 | Knockout | NUP85 | cell proliferation | Bladder Carcinoma | Gene: NUP85 (nucleoporin 85)
Type: protein-coding
Summary: This gene encodes a protein component of the Nup107-160 subunit of the nuclear pore complex. Nuclear pore complexes are embedded in the nuclear envelope and promote bidirectional transport of macromolecules between the cytoplasm and nucleus. The... |
Does Knockout of RSRC2 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 1 | 220 | Knockout | RSRC2 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: RSRC2 (arginine and serine rich coiled-coil 2)
Type: protein-coding
Summary: Enables RNA binding activity. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: RNA binding, protein binding
Pathways:
UniProt: Q7L4I2
Entrez ID: 65117 |
Does Knockout of ELF4 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,658 | Knockout | ELF4 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: ELF4 (E74 like ETS transcription factor 4)
Type: protein-coding
Summary: The protein encoded by this gene is a transcriptional activator that binds and activates the promoters of the CSF2, IL3, IL8, and PRF1 genes. The encoded protein is involved in natural killer cell development and function, in... |
Does Knockout of POLN in Retinal Pigment Epithelium Cell Line causally result in response to chemicals? | 0 | 1,329 | Knockout | POLN | response to chemicals | Retinal Pigment Epithelium Cell Line | Gene: POLN (DNA polymerase nu)
Type: protein-coding
Summary: This gene encodes a DNA polymerase type-A family member. The encoded protein plays a role in DNA repair and homologous recombination. This gene shares its 5' exons with some transcripts from overlapping GeneID: 79441, which encodes an augmenti... |
Does Knockout of E4F1 in Renal Cancer Cell Line causally result in cell proliferation? | 1 | 319 | Knockout | E4F1 | cell proliferation | Renal Cancer Cell Line | Gene: E4F1 (E4F transcription factor 1)
Type: protein-coding
Summary: The zinc finger protein encoded by this gene is one of several cellular transcription factors whose DNA-binding activities are regulated through the action of adenovirus E1A. A 50-kDa amino-terminal product is generated from the full-... |
Does Knockout of SCNN1G in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 815 | Knockout | SCNN1G | cell proliferation | Colonic Cancer Cell Line | Gene: SCNN1G (sodium channel epithelial 1 subunit gamma)
Type: protein-coding
Summary: Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma... |
Does Knockout of SUPT16H in T-lymphoma cell line causally result in cell proliferation? | 1 | 478 | Knockout | SUPT16H | cell proliferation | T-lymphoma cell line | Gene: SUPT16H (SPT16 homolog, facilitates chromatin remodeling subunit)
Type: protein-coding
Summary: Transcription of protein-coding genes can be reconstituted on naked DNA with only the general transcription factors and RNA polymerase II. However, this minimal system cannot transcribe DNA packaged int... |
Does Knockout of SYNJ2 in Breast Cancer Cell Line causally result in cell proliferation? | 0 | 235 | Knockout | SYNJ2 | cell proliferation | Breast Cancer Cell Line | Gene: SYNJ2 (synaptojanin 2)
Type: protein-coding
Summary: The gene is a member of the inositol-polyphosphate 5-phosphatase family. The encoded protein interacts with the ras-related C3 botulinum toxin substrate 1, which causes translocation of the encoded protein to the plasma membrane where it inhibit... |
Does Knockout of REL in Endometrial Cancer Cell Line causally result in cell proliferation? | 0 | 758 | Knockout | REL | cell proliferation | Endometrial Cancer Cell Line | Gene: REL (REL proto-oncogene, NF-kB subunit)
Type: protein-coding
Summary: This gene encodes a protein that belongs to the Rel homology domain/immunoglobulin-like fold, plexin, transcription factor (RHD/IPT) family. Members of this family regulate genes involved in apoptosis, inflammation, the immune r... |
Does Knockout of WDR1 in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 1,311 | Knockout | WDR1 | cell proliferation | Oral Squamous Cell Carcinoma Cell Line | Gene: WDR1 (WD repeat domain 1)
Type: protein-coding
Summary: This gene encodes a protein containing 9 WD repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, mostly including a trp-asp at the C-terminal end. WD domains are involved in protein-protein... |
Does Knockout of NAGS in Hepatoma Cell Line causally result in response to virus? | 0 | 2,437 | Knockout | NAGS | response to virus | Hepatoma Cell Line | Gene: NAGS (N-acetylglutamate synthase)
Type: protein-coding
Summary: The N-acetylglutamate synthase gene encodes a mitochondrial enzyme that catalyzes the formation of N-acetylglutamate (NAG) from glutamate and acetyl coenzyme-A. NAG is a cofactor of carbamyl phosphate synthetase I (CPSI), the first en... |
Does Knockout of WDR1 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 69 | Knockout | WDR1 | cell proliferation | Monocytic Leukemia Cell Line | Gene: WDR1 (WD repeat domain 1)
Type: protein-coding
Summary: This gene encodes a protein containing 9 WD repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, mostly including a trp-asp at the C-terminal end. WD domains are involved in protein-protein... |
Does Knockout of ARHGEF18 in Breast Cancer Cell Line causally result in cell proliferation? | 0 | 235 | Knockout | ARHGEF18 | cell proliferation | Breast Cancer Cell Line | Gene: ARHGEF18 (Rho/Rac guanine nucleotide exchange factor 18)
Type: protein-coding
Summary: Rho GTPases are GTP binding proteins that regulate a wide spectrum of cellular functions. These cellular processes include cytoskeletal rearrangements, gene transcription, cell growth and motility. Activation of... |
Does Knockout of PAXBP1 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals? | 1 | 1,736 | Knockout | PAXBP1 | response to chemicals | Colonic Adenocarcinoma Cell Line | Gene: PAXBP1 (PAX3 and PAX7 binding protein 1)
Type: protein-coding
Summary: This gene encodes a protein that may bind to GC-rich DNA sequences, which suggests its involvement in the regulation of transcription. Alternative splicing of this gene results in multiple transcript variants. [provided by RefS... |
Does Knockout of ARID1A in Hepatoma Cell Line causally result in response to virus? | 1 | 2,437 | Knockout | ARID1A | response to virus | Hepatoma Cell Line | Gene: ARID1A (AT-rich interaction domain 1A)
Type: protein-coding
Summary: This gene encodes a member of the SWI/SNF family, whose members have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded pr... |
Does Knockout of DCTN4 in Glioblastoma Cell Line causally result in cell proliferation? | 1 | 519 | Knockout | DCTN4 | cell proliferation | Glioblastoma Cell Line | Gene: DCTN4 (dynactin subunit 4)
Type: protein-coding
Summary: Enables protein N-terminus binding activity. Located in centrosome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: cell cortex, centrosome, cytoplasm, cytoplasmic dynein complex, cytoskeleton, cytosol, dynac... |
Does Knockout of HSPA9 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 1 | 220 | Knockout | HSPA9 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: HSPA9 (heat shock protein family A (Hsp70) member 9)
Type: protein-coding
Summary: This gene encodes a member of the heat shock protein 70 gene family. The encoded protein is primarily localized to the mitochondria but is also found in the endoplasmic reticulum, plasma membrane and cytoplasmic ves... |
Does Knockout of CEACAM6 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 427 | Knockout | CEACAM6 | cell proliferation | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: CEACAM6 (CEA cell adhesion molecule 6)
Type: protein-coding
Summary: This gene encodes a protein that belongs to the carcinoembryonic antigen (CEA) family whose members are glycosyl phosphatidyl inositol (GPI) anchored cell surface glycoproteins. Members of this family play a role in cell adhesion... |
Does Knockout of RRP7A in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 1,311 | Knockout | RRP7A | cell proliferation | Oral Squamous Cell Carcinoma Cell Line | Gene: RRP7A (ribosomal RNA processing 7 homolog A)
Type: protein-coding
Summary: Enables RNA binding activity. Predicted to be involved in rRNA processing and ribosomal small subunit assembly. Predicted to act upstream of or within blastocyst formation. Predicted to be located in nucleoplasm. Predicted ... |
Does Knockout of CDYL in Cervical Adenocarcinoma Cell Line causally result in protein/peptide accumulation? | 1 | 2,404 | Knockout | CDYL | protein/peptide accumulation | Cervical Adenocarcinoma Cell Line | Gene: CDYL (chromodomain Y like)
Type: protein-coding
Summary: Chromodomain Y is a primate-specific Y-chromosomal gene family expressed exclusively in the testis and implicated in infertility. Although the Y-linked genes are testis-specific, this autosomal gene is ubiquitously expressed. The Y-linked ge... |
Does Knockout of GABRD in Endometrial Cancer Cell Line causally result in cell proliferation? | 0 | 758 | Knockout | GABRD | cell proliferation | Endometrial Cancer Cell Line | Gene: GABRD (gamma-aminobutyric acid type A receptor subunit delta)
Type: protein-coding
Summary: Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these chan... |
Does Knockout of LYG1 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 334 | Knockout | LYG1 | cell proliferation | Esophageal Squamous Cell Carcinoma Cell Line | Gene: LYG1 (lysozyme g1)
Type: protein-coding
Summary: Predicted to enable lysozyme activity. Predicted to be involved in defense response to Gram-positive bacterium. Predicted to be active in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: defense ... |
Does Knockout of PPP1R36 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 427 | Knockout | PPP1R36 | cell proliferation | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: PPP1R36 (protein phosphatase 1 regulatory subunit 36)
Type: protein-coding
Summary: Predicted to enable phosphatase binding activity and protein phosphatase inhibitor activity. Predicted to be involved in negative regulation of phosphatase activity. [provided by Alliance of Genome Resources, Apr 2... |
Does Knockout of POLR1E in Cancer Cell Line causally result in cell proliferation? | 1 | 193 | Knockout | POLR1E | cell proliferation | Cancer Cell Line | Gene: POLR1E (RNA polymerase I subunit E)
Type: protein-coding
Summary: Predicted to enable DNA binding activity; DNA-directed 5'-3' RNA polymerase activity; and RNA polymerase I general transcription initiation factor binding activity. Involved in nucleolar large rRNA transcription by RNA polymerase I.... |
Does Knockout of ACTN1 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 839 | Knockout | ACTN1 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: ACTN1 (actinin alpha 1)
Type: protein-coding
Summary: Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different... |
Does Knockout of PPRC1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 427 | Knockout | PPRC1 | cell proliferation | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: PPRC1 (PPARG related coactivator 1)
Type: protein-coding
Summary: The protein encoded by this gene is similar to PPAR-gamma coactivator 1 (PPARGC1/PGC-1), a protein that can activate mitochondrial biogenesis in part through a direct interaction with nuclear respiratory factor 1 (NRF1). This protei... |
Does Knockout of TNFRSF10C in Cervical Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 1,352 | Knockout | TNFRSF10C | response to chemicals | Cervical Adenocarcinoma Cell Line | Gene: TNFRSF10C (TNF receptor superfamily member 10c)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not... |
Does Knockout of TPT1 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 1 | 2,119 | Knockout | TPT1 | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: TPT1 (tumor protein, translationally-controlled 1)
Type: protein-coding
Summary: This gene encodes a protein that is a regulator of cellular growth and proliferation. Its mRNA is highly structured and contains an oligopyrimidine tract (5'-TOP) in its 5' untranslated region that functions to repres... |
Does Knockout of MBTPS1 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 305 | Knockout | MBTPS1 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: MBTPS1 (membrane bound transcription factor peptidase, site 1)
Type: protein-coding
Summary: This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches o... |
Does Knockout of NEU3 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 0 | 1,032 | Knockout | NEU3 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: NEU3 (neuraminidase 3)
Type: protein-coding
Summary: This gene product belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. It is localized in the plasma membrane, and its activity is specific for gangliosides. It may play a role in m... |
Does Knockout of RELT in Lymphoma or Leukaemia Cell Line causally result in protein/peptide accumulation? | 0 | 1,218 | Knockout | RELT | protein/peptide accumulation | Lymphoma or Leukaemia Cell Line | Gene: RELT (RELT TNF receptor)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is especially abundant in hematologic tissues. It has been shown to activate the NF-kappaB pathway and selectively bind TNF receptor-associated factor ... |
Does Knockout of UBXN7 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 2,459 | Knockout | UBXN7 | response to chemicals | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: UBXN7 (UBX domain protein 7)
Type: protein-coding
Summary: Enables ubiquitin binding activity and ubiquitin protein ligase binding activity. Located in nuclear body. Part of VCP-NPL4-UFD1 AAA ATPase complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: RNA polym... |
Does Knockout of UBR5 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals? | 0 | 1,329 | Knockout | UBR5 | response to chemicals | Retinal Pigment Epithelium Cell Line | Gene: UBR5 (ubiquitin protein ligase E3 component n-recognin 5)
Type: protein-coding
Summary: This gene encodes a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family. The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific prote... |
Does Knockout of SMAD6 in Cervical Adenocarcinoma Cell Line causally result in protein/peptide accumulation? | 0 | 2,404 | Knockout | SMAD6 | protein/peptide accumulation | Cervical Adenocarcinoma Cell Line | Gene: SMAD6 (SMAD family member 6)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the SMAD family of proteins, which are related to Drosophila 'mothers against decapentaplegic' (Mad) and C. elegans Sma. SMAD proteins are signal transducers and transcriptional modulators that m... |
Does Knockout of ADAM22 in Astrocytoma Cell Line causally result in cell proliferation? | 0 | 904 | Knockout | ADAM22 | cell proliferation | Astrocytoma Cell Line | Gene: ADAM22 (ADAM metallopeptidase domain 22)
Type: protein-coding
Summary: This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a var... |
Does Knockout of ZIC1 in Hepatoma Cell Line causally result in response to virus? | 0 | 2,447 | Knockout | ZIC1 | response to virus | Hepatoma Cell Line | Gene: ZIC1 (Zic family zinc finger 1)
Type: protein-coding
Summary: This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development. Aberrant expression of this gene is seen in medulloblastoma, a childhood brain tumor. This gene is ... |
Does Knockout of ACYP1 in Breast Cancer Cell Line causally result in cell proliferation? | 0 | 235 | Knockout | ACYP1 | cell proliferation | Breast Cancer Cell Line | Gene: ACYP1 (acylphosphatase 1)
Type: protein-coding
Summary: This gene is a member of the acylphosphatase family. The encoded protein is a small cytosolic enzyme that catalyzes the hydrolysis of the carboxyl-phosphate bond of acylphosphates. Two isoenzymes have been isolated and described based on thei... |
Does Knockout of RANBP1 in acute lymphoblastic leukemia cell line causally result in cell proliferation? | 1 | 1,957 | Knockout | RANBP1 | cell proliferation | acute lymphoblastic leukemia cell line | Gene: RANBP1 (RAN binding protein 1)
Type: protein-coding
Summary: This gene encodes a protein that forms a complex with Ras-related nuclear protein (Ran) and metabolizes guanoside triphosphate (GTP). This complex participates in the regulation of the cell cycle by controlling transport of proteins and ... |
Does Knockout of ABLIM2 in Lung Cancer Cell Line causally result in response to virus? | 0 | 1,433 | Knockout | ABLIM2 | response to virus | Lung Cancer Cell Line | Gene: ABLIM2 (actin binding LIM protein family member 2)
Type: protein-coding
Summary: Predicted to enable actin filament binding activity. Predicted to be involved in lamellipodium assembly. Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II. Located in act... |
Does Knockout of TAAR6 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 865 | Knockout | TAAR6 | cell proliferation | Colonic Cancer Cell Line | Gene: TAAR6 (trace amine associated receptor 6)
Type: protein-coding
Summary: This gene encodes a seven-transmembrane G-protein-coupled receptor that likely functions as a receptor for endogenous trace amines. Mutations in this gene may be associated with schizophrenia.[provided by RefSeq, Feb 2010].
... |
Does Knockout of WNK1 in Glioma Cell Line causally result in protein/peptide accumulation? | 0 | 589 | Knockout | WNK1 | protein/peptide accumulation | Glioma Cell Line | Gene: WNK1 (WNK lysine deficient protein kinase 1)
Type: protein-coding
Summary: This gene encodes a member of the WNK subfamily of serine/threonine protein kinases. The encoded protein may be a key regulator of blood pressure by controlling the transport of sodium and chloride ions. Mutations in this g... |
Does Knockout of TSHZ2 in Renal Cancer Cell Line causally result in cell proliferation? | 0 | 319 | Knockout | TSHZ2 | cell proliferation | Renal Cancer Cell Line | Gene: TSHZ2 (teashirt zinc finger homeobox 2)
Type: protein-coding
Summary: This gene is a member of the teashirt C2H2-type zinc-finger protein family of transcription factors. This gene encodes a protein with five C2H2-type zinc fingers, a homeobox DNA-binding domain and a coiled-coil domain. This nucl... |
Does Knockout of KRTAP1-5 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 815 | Knockout | KRTAP1-5 | cell proliferation | Colonic Cancer Cell Line | Gene: KRTAP1-5 (keratin associated protein 1-5)
Type: protein-coding
Summary: This protein is a member of the keratin-associated protein (KAP) family. The KAP proteins form a matrix of keratin intermediate filaments which contribute to the structure of hair fibers. KAP family members appear to have uniq... |
Does Knockout of LIF in Lung Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 387 | Knockout | LIF | cell proliferation | Lung Adenocarcinoma Cell Line | Gene: LIF (LIF interleukin 6 family cytokine)
Type: protein-coding
Summary: The protein encoded by this gene is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cel... |
Does Knockout of AFAP1L2 in Non-Small Cell Lung Adenocarcinoma Cell Line causally result in response to chemicals? | 1 | 1,391 | Knockout | AFAP1L2 | response to chemicals | Non-Small Cell Lung Adenocarcinoma Cell Line | Gene: AFAP1L2 (actin filament associated protein 1 like 2)
Type: protein-coding
Summary: Enables SH2 domain binding activity; SH3 domain binding activity; and protein tyrosine kinase activator activity. Involved in several processes, including positive regulation of epidermal growth factor receptor sign... |
Does Knockout of DDX55 in Endometrial Cancer Cell Line causally result in cell proliferation? | 1 | 758 | Knockout | DDX55 | cell proliferation | Endometrial Cancer Cell Line | Gene: DDX55 (DEAD-box helicase 55)
Type: protein-coding
Summary: This gene encodes a member of protein family containing a characteristic Asp-Glu-Ala-Asp (DEAD) motif. These proteins are putative RNA helicases, and may be involved in a range of nuclear processes including translational initiation, nucle... |
Does Knockout of NOS1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 0 | 1,789 | Knockout | NOS1 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: NOS1 (nitric oxide synthase 1)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the family of nitric oxide synthases, which synthesize nitric oxide from L-arginine. Nitric oxide is a reactive free radical, which acts as a biologic mediator in several processes, including n... |
Does Knockout of NCSTN in Retinal Pigment Epithelium Cell Line causally result in response to chemicals? | 0 | 1,329 | Knockout | NCSTN | response to chemicals | Retinal Pigment Epithelium Cell Line | Gene: NCSTN (nicastrin)
Type: protein-coding
Summary: This gene encodes a type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and m... |
Does Knockout of CADM3 in Endometrial Cancer Cell Line causally result in cell proliferation? | 0 | 758 | Knockout | CADM3 | cell proliferation | Endometrial Cancer Cell Line | Gene: CADM3 (cell adhesion molecule 3)
Type: protein-coding
Summary: The protein encoded by this gene is a calcium-independent cell-cell adhesion protein that can form homodimers or heterodimers with other nectin proteins. The encoded protein has both homophilic and heterophilic cell-cell adhesion activ... |
Does Knockout of IRF2 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 427 | Knockout | IRF2 | cell proliferation | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: IRF2 (interferon regulatory factor 2)
Type: protein-coding
Summary: IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and pres... |
Does Knockout of MYRFL in Retinal Pigment Epithelium Cell Line causally result in response to chemicals? | 0 | 1,340 | Knockout | MYRFL | response to chemicals | Retinal Pigment Epithelium Cell Line | Gene: MYRFL (myelin regulatory factor like)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity and sequence-specific DNA binding activity. Predicted to be involved in positive regulation of transcription, DNA-templated and protein autoprocessing. Predicted to be ... |
Does Knockout of RUBCNL in Retinal Pigment Epithelium Cell Line causally result in response to chemicals? | 0 | 1,329 | Knockout | RUBCNL | response to chemicals | Retinal Pigment Epithelium Cell Line | Gene: RUBCNL (rubicon like autophagy enhancer)
Type: protein-coding
Summary: This gene encodes a cysteine-rich protein that contains a putative zinc-RING and/or ribbon domain. The encoded protein is related to Run domain Beclin-1-interacting and cysteine-rich domain-containing protein, which plays a rol... |
Does Knockout of SNRNP35 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 427 | Knockout | SNRNP35 | cell proliferation | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: SNRNP35 (small nuclear ribonucleoprotein U11/U12 subunit 35)
Type: protein-coding
Summary: The protein encoded by this gene is a homolog of the U1-snRNP binding protein. The N-terminal half contains a RNA recognition motif and the C-terminal half is rich in Arg/Asp and Arg/Glu dipeptides, which is... |
Does Knockout of CEP95 in Primary Effusion Lymphoma Cell Line causally result in response to chemicals? | 0 | 1,061 | Knockout | CEP95 | response to chemicals | Primary Effusion Lymphoma Cell Line | Gene: CEP95 (centrosomal protein 95)
Type: protein-coding
Summary: Located in centrosome and spindle pole. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: centrosome, cytoplasm, cytoskeleton, spindle pole
Pathways:
UniProt: Q96GE4
Entrez ID: 90... |
Does Knockout of PPRC1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 2,459 | Knockout | PPRC1 | response to chemicals | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: PPRC1 (PPARG related coactivator 1)
Type: protein-coding
Summary: The protein encoded by this gene is similar to PPAR-gamma coactivator 1 (PPARGC1/PGC-1), a protein that can activate mitochondrial biogenesis in part through a direct interaction with nuclear respiratory factor 1 (NRF1). This protei... |
Does Knockout of FCER2 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 815 | Knockout | FCER2 | cell proliferation | Colonic Cancer Cell Line | Gene: FCER2 (Fc epsilon receptor II)
Type: protein-coding
Summary: The protein encoded by this gene is a B-cell specific antigen, and a low-affinity receptor for IgE. It has essential roles in B cell growth and differentiation, and the regulation of IgE production. This protein also exists as a soluble ... |
Does Knockout of TBC1D3C in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 206 | Knockout | TBC1D3C | cell proliferation | Monocytic Leukemia Cell Line | Gene: TBC1D3C (TBC1 domain family member 3C)
Type: protein-coding
Summary: This gene represents one of a cluster of related genes found on chromosome 17. The proteins encoded by this gene family contain a TBC (Tre-2, Bub2p, and Cdc16p) domain and may be involved in GTPase signaling and vesicle trafficki... |
Does Knockout of ACTR1B in Ovarian Cancer Cell Line causally result in cell proliferation? | 0 | 699 | Knockout | ACTR1B | cell proliferation | Ovarian Cancer Cell Line | Gene: ACTR1B (actin related protein 1B)
Type: protein-coding
Summary: This gene encodes a 42.3 kD subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein and is involved in a diverse array of ce... |
Does Knockout of B4GALT4 in Bladder Carcinoma causally result in cell proliferation? | 0 | 489 | Knockout | B4GALT4 | cell proliferation | Bladder Carcinoma | Gene: B4GALT4 (beta-1,4-galactosyltransferase 4)
Type: protein-coding
Summary: This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galact... |
Does Knockout of ZNF575 in Diffuse Large B-cell Lymphoma Cell causally result in response to chemicals? | 0 | 2,222 | Knockout | ZNF575 | response to chemicals | Diffuse Large B-cell Lymphoma Cell | Gene: ZNF575 (zinc finger protein 575)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RN... |
Does Knockout of IARS2 in Endometrial Cancer Cell Line causally result in cell proliferation? | 1 | 287 | Knockout | IARS2 | cell proliferation | Endometrial Cancer Cell Line | Gene: IARS2 (isoleucyl-tRNA synthetase 2, mitochondrial)
Type: protein-coding
Summary: Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAS, aminoacyl-tRNA synthetases ... |
Does Knockout of MRGBP in Neuroblastoma Cell Line causally result in cell proliferation? | 1 | 824 | Knockout | MRGBP | cell proliferation | Neuroblastoma Cell Line | Gene: MRGBP (MRG domain binding protein)
Type: protein-coding
Summary: Predicted to be involved in histone acetylation and regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: chromatin organization, po... |
Does Knockout of DPEP3 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 305 | Knockout | DPEP3 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: DPEP3 (dipeptidase 3)
Type: protein-coding
Summary: This gene encodes a membrane-bound glycoprotein from the family of dipeptidases involved in hydrolytic metabolism of various dipeptides, including penem and carbapenem beta-lactam antibiotics. This gene is located on chromosome 16 in a cluster wi... |
Does Knockout of GTF2B in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 865 | Knockout | GTF2B | cell proliferation | Colonic Cancer Cell Line | Gene: GTF2B (general transcription factor IIB)
Type: protein-coding
Summary: This gene encodes the general transcription factor IIB, one of the ubiquitous factors required for transcription initiation by RNA polymerase II. The protein localizes to the nucleus where it forms a complex (the DAB complex) w... |
Does Knockout of GINS1 in Cancer Cell Line causally result in cell proliferation? | 1 | 948 | Knockout | GINS1 | cell proliferation | Cancer Cell Line | Gene: GINS1 (GINS complex subunit 1)
Type: protein-coding
Summary: The yeast heterotetrameric GINS complex is made up of Sld5 (GINS4; MIM 610611), Psf1, Psf2 (GINS2; MIM 610609), and Psf3 (GINS3; MIM 610610). The formation of the GINS complex is essential for the initiation of DNA replication in yeast a... |
Does Knockout of TAF10 in Bladder Carcinoma causally result in cell proliferation? | 1 | 489 | Knockout | TAF10 | cell proliferation | Bladder Carcinoma | Gene: TAF10 (TATA-box binding protein associated factor 10)
Type: protein-coding
Summary: Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core prom... |
Does Knockout of SPRR1B in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 951 | Knockout | SPRR1B | cell proliferation | Colonic Cancer Cell Line | Gene: SPRR1B (small proline rich protein 1B)
Type: protein-coding
Summary: The protein encoded by this gene is an envelope protein of keratinocytes. The encoded protein is crosslinked to membrane proteins by transglutaminase, forming an insoluble layer under the plasma membrane. This protein is proline-... |
Does Knockout of GPR34 in Colorectal Cancer Cell Line causally result in cell proliferation? | 0 | 783 | Knockout | GPR34 | cell proliferation | Colorectal Cancer Cell Line | Gene: GPR34 (G protein-coupled receptor 34)
Type: protein-coding
Summary: G protein-coupled receptors (GPCRs), such as GPR34, are integral membrane proteins containing 7 putative transmembrane domains (TMs). These proteins mediate signals to the interior of the cell via activation of heterotrimeric G pr... |
Does Knockout of KRT6C in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 0 | 1,246 | Knockout | KRT6C | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: KRT6C (keratin 6C)
Type: protein-coding
Summary: Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. The type II keratins are clustered in a region of chromosome 12q13. [provided by ... |
Does Knockout of AKAP3 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation? | 0 | 1,996 | Knockout | AKAP3 | cell proliferation | Pre-B Acute Lymphoblastic Leukemia Cell Line | Gene: AKAP3 (A-kinase anchoring protein 3)
Type: protein-coding
Summary: This gene encodes a member of A-kinase anchoring proteins (AKAPs), a family of functionally related proteins that target protein kinase A to discrete locations within the cell. The encoded protein is reported to participate in prot... |
Does Knockout of CERS1 in Glioblastoma Cell Line causally result in cell proliferation? | 0 | 906 | Knockout | CERS1 | cell proliferation | Glioblastoma Cell Line | Gene: CERS1 (ceramide synthase 1)
Type: protein-coding
Summary: This gene encodes a ceramide synthase enzyme, which catalyzes the synthesis of ceramide, the hydrophobic moiety of sphingolipids. The encoded enzyme synthesizes 18-carbon (C18) ceramide in brain neurons. Elevated expression of this gene may... |
Does Knockout of TEX10 in Urinary Bladder Cancer Cell Line causally result in cell proliferation? | 1 | 180 | Knockout | TEX10 | cell proliferation | Urinary Bladder Cancer Cell Line | Gene: TEX10 (testis expressed 10)
Type: protein-coding
Summary: Located in mitochondrion and nucleoplasm. Part of MLL1 complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: MLL1 complex, cytoplasm, mitochondrion, nucleolus, nucleoplasm, nucleus
Pathways: Majo... |
Does Knockout of TNFRSF14 in Cervical Adenocarcinoma Cell Line causally result in response to virus? | 0 | 2,430 | Knockout | TNFRSF14 | response to virus | Cervical Adenocarcinoma Cell Line | Gene: TNFRSF14 (TNF receptor superfamily member 14)
Type: protein-coding
Summary: This gene encodes a member of the TNF (tumor necrosis factor) receptor superfamily. The encoded protein functions in signal transduction pathways that activate inflammatory and inhibitory T-cell immune response. It binds h... |
Does Knockout of PGAP2 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 334 | Knockout | PGAP2 | cell proliferation | Esophageal Squamous Cell Carcinoma Cell Line | Gene: PGAP2 (post-GPI attachment to proteins 2)
Type: protein-coding
Summary: The protein encoded by this gene plays a role in the maturation of glycosylphosphatidylinositol (GPI) anchors on GPI-anchored proteins. Mutations in this gene are associated with an autosomal recessive syndrome characterized b... |
Does Knockout of SLC39A14 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 0 | 206 | Knockout | SLC39A14 | cell proliferation | Monocytic Leukemia Cell Line | Gene: SLC39A14 (solute carrier family 39 member 14)
Type: protein-coding
Summary: This gene encodes a member of the the SLC39A family of divalent metal transporters that mediates the cellular uptake of manganese, zinc, iron, and cadmium. The encoded protein contains eight transmembrane domains, a histid... |
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