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string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of OR10K1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,658
|
Knockout
|
OR10K1
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: OR10K1 (olfactory receptor family 10 subfamily K member 1)
Type: protein-coding
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, detection of chemical stimulus involved in sensory perception of smell, sensory perception of smell, signal transduction; MF: G protein-coupled receptor activity, odorant binding, olfactory receptor activity; CC: membrane, plasma membrane
Pathways: Expression and translocation of olfactory receptors, Olfactory Signaling Pathway, Olfactory transduction - Homo sapiens (human), Sensory Perception
UniProt: Q8NGX5
Entrez ID: 391109
|
Does Knockout of FIG4 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 527
|
Knockout
|
FIG4
|
cell proliferation
|
Melanoma Cell Line
|
Gene: FIG4 (FIG4 phosphoinositide 5-phosphatase)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the SAC domain-containing protein gene family. The SAC domain, approximately 400 amino acids in length and consisting of seven conserved motifs, has been shown to possess phosphoinositide phosphatase activity. The yeast homolog, Sac1p, is involved in the regulation of various phosphoinositides, and affects diverse cellular functions such as actin cytoskeleton organization, Golgi function, and maintenance of vacuole morphology. Membrane-bound phosphoinositides function as signaling molecules and play a key role in vesicle trafficking in eukaryotic cells. Mutations in this gene have been associated with Charcot-Marie-Tooth disease, type 4J. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: locomotory behavior, myelin assembly, myelination, negative regulation of myelination, neuron development, phosphatidylinositol biosynthetic process, phosphatidylinositol dephosphorylation, phosphatidylinositol metabolic process, phosphatidylinositol-3-phosphate biosynthetic process, pigmentation, positive regulation of neuron projection development, vacuole organization; MF: hydrolase activity, phosphatase activity, phosphatidylinositol bisphosphate phosphatase activity, phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity, phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity, phosphatidylinositol-3-phosphate phosphatase activity, phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity, phosphatidylinositol-4-phosphate phosphatase activity, protein binding, protein serine/threonine phosphatase activity; CC: Golgi membrane, early endosome membrane, endosome, endosome membrane, intracellular membrane-bounded organelle, late endosome membrane, lipid droplet, membrane, recycling endosome
Pathways: 3-phosphoinositide biosynthesis, Amyotrophic lateral sclerosis - Homo sapiens (human), Inositol Metabolism, Inositol phosphate metabolism - Homo sapiens (human), Intracellular trafficking proteins involved in CMT neuropathy, Joubert syndrome, Metabolism, Metabolism of lipids, PI Metabolism, Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Phosphatidylinositol Phosphate Metabolism, Phospholipid metabolism, Synthesis of PIPs at the Golgi membrane, Synthesis of PIPs at the early endosome membrane, Synthesis of PIPs at the late endosome membrane, superpathway of inositol phosphate compounds
UniProt: Q92562
Entrez ID: 9896
|
Does Knockout of SRP68 in Ovarian Cancer Cell Line causally result in cell proliferation?
| 1
| 699
|
Knockout
|
SRP68
|
cell proliferation
|
Ovarian Cancer Cell Line
|
Gene: SRP68 (signal recognition particle 68)
Type: protein-coding
Summary: This gene encodes a subunit of the signal recognition particle (SRP). The SRP is a ribonucleoprotein complex that transports secreted and membrane proteins to the endoplasmic reticulum for processing. The complex includes a 7S RNA and six protein subunits. The encoded protein is the 68kDa component of the SRP, and forms a heterodimer with the 72kDa subunit that is required for SRP function. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and three pseudogenes of this gene are located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, May 2012].
Gene Ontology: BP: SRP-dependent cotranslational protein targeting to membrane, response to xenobiotic stimulus; MF: 7S RNA binding, RNA binding, endoplasmic reticulum signal peptide binding, protein binding, protein domain specific binding, ribosome binding, signal recognition particle binding; CC: cytoplasm, cytosol, endoplasmic reticulum, focal adhesion, nucleolus, nucleus, ribonucleoprotein complex, ribosome, signal recognition particle, signal recognition particle, endoplasmic reticulum targeting
Pathways: Metabolism of proteins, Protein export - Homo sapiens (human), SRP-dependent cotranslational protein targeting to membrane, Translation
UniProt: Q9UHB9
Entrez ID: 6730
|
Does Knockout of MIR15B in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals?
| 0
| 2,383
|
Knockout
|
MIR15B
|
response to chemicals
|
Chronic Myelogenous Leukemia Cell Line
|
Gene: MIR15B (microRNA 15b)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
Gene Ontology: BP: branching involved in blood vessel morphogenesis, cardiac muscle hypertrophy, miRNA-mediated gene silencing by inhibition of translation, miRNA-mediated post-transcriptional gene silencing, negative regulation of G1/S transition of mitotic cell cycle, negative regulation of amyloid precursor protein catabolic process, negative regulation of amyloid-beta formation, negative regulation of angiogenesis, negative regulation of blood vessel endothelial cell migration, negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis, negative regulation of canonical NF-kappaB signal transduction, negative regulation of cell population proliferation, negative regulation of cellular response to insulin stimulus, negative regulation of glycogen biosynthetic process, negative regulation of inflammatory response, negative regulation of insulin receptor signaling pathway, negative regulation of mitotic cell cycle, negative regulation of neuron apoptotic process, negative regulation of non-canonical NF-kappaB signal transduction, negative regulation of transforming growth factor beta receptor signaling pathway, negative regulation of trophoblast cell migration, negative regulation of vascular associated smooth muscle cell differentiation, negative regulation of vascular endothelial cell proliferation, negative regulation of vascular endothelial growth factor production, negative regulation of wound healing, positive regulation of apoptotic process, positive regulation of connective tissue replacement, positive regulation of translation; MF: mRNA 3'-UTR binding, mRNA base-pairing post-transcriptional repressor activity; CC: RISC complex, extracellular space, extracellular vesicle
Pathways: Ectoderm Differentiation, MicroRNAs in cancer - Homo sapiens (human), MicroRNAs in cardiomyocyte hypertrophy, miRNA targets in ECM and membrane receptors, miRNAs involved in DNA damage response
UniProt:
Entrez ID: 406949
|
Does Knockout of TSPY3 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 0
| 1,246
|
Knockout
|
TSPY3
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: TSPY3 (testis specific protein Y-linked 3)
Type: protein-coding
Summary: Predicted to enable chromatin binding activity and histone binding activity. Predicted to be involved in sex differentiation. Predicted to be located in cytoplasm. Predicted to be active in chromatin and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cell differentiation, gonadal mesoderm development, nucleosome assembly, spermatogenesis; MF: chromatin binding, histone binding; CC: chromatin, cytoplasm, nucleus
Pathways:
UniProt: P0CV98, Q01534, P0CW01
Entrez ID: 728137
|
Does Knockout of SP2 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 527
|
Knockout
|
SP2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: SP2 (Sp2 transcription factor)
Type: protein-coding
Summary: This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein contains the least conserved DNA-binding domain within the Sp subfamily of proteins, and its DNA sequence specificity differs from the other Sp proteins. It localizes primarily within subnuclear foci associated with the nuclear matrix, and can activate or in some cases repress expression from different promoters. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: immune response, negative regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, histone deacetylase binding, metal ion binding, protein binding, sequence-specific double-stranded DNA binding, zinc ion binding; CC: chromatin, nucleoplasm, nucleus
Pathways:
UniProt: Q02086
Entrez ID: 6668
|
Does Knockout of IPO9 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,352
|
Knockout
|
IPO9
|
response to chemicals
|
Cervical Adenocarcinoma Cell Line
|
Gene: IPO9 (importin 9)
Type: protein-coding
Summary: Enables nuclear import signal receptor activity. Involved in protein import into nucleus. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: intracellular protein transport, proteasomal protein catabolic process, proteasome localization, protein import into nucleus, protein transport; MF: histone binding, histone chaperone activity, nuclear import signal receptor activity, protein binding, small GTPase binding; CC: cytoplasm, cytosol, membrane, nuclear envelope, nucleoplasm, nucleus
Pathways:
UniProt: Q96P70
Entrez ID: 55705
|
Does Knockout of RENBP in Monocytic Leukemia Cell Line causally result in RNA accumulation?
| 0
| 1,968
|
Knockout
|
RENBP
|
RNA accumulation
|
Monocytic Leukemia Cell Line
|
Gene: RENBP (renin binding protein)
Type: protein-coding
Summary: The gene product inhibits renin activity by forming a dimer with renin, a complex known as high molecular weight renin. The encoded protein contains a leucine zipper domain, which is essential for its dimerization with renin. The gene product can catalyze the interconversion of N-acetylglucosamine to N-acetylmannosamine, indicating that it is a GlcNAc 2-epimerase. Transcript variants utilizing alternative promoters have been described in the literature. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: N-acetylglucosamine metabolic process, N-acetylmannosamine metabolic process, N-acetylneuraminate catabolic process, amino sugar metabolic process, carbohydrate metabolic process, regulation of blood pressure; MF: N-acylglucosamine 2-epimerase activity, endopeptidase inhibitor activity, identical protein binding, isomerase activity, peptidase inhibitor activity, protein binding; CC: cytosol, extracellular exosome
Pathways: Amino Sugar Metabolism, Amino sugar and nucleotide sugar metabolism - Homo sapiens (human), Asparagine N-linked glycosylation, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, G(M2)-Gangliosidosis: Variant B, Tay-sachs disease, Metabolism of proteins, Post-translational protein modification, Salla Disease/Infantile Sialic Acid Storage Disease, Sialuria or French Type Sialuria, Synthesis of UDP-N-acetyl-glucosamine, Synthesis of substrates in N-glycan biosythesis, Tay-Sachs Disease
UniProt: P51606
Entrez ID: 5973
|
Does Knockout of DMAP1 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 1,736
|
Knockout
|
DMAP1
|
response to chemicals
|
Colonic Adenocarcinoma Cell Line
|
Gene: DMAP1 (DNA methyltransferase 1 associated protein 1)
Type: protein-coding
Summary: This gene encodes a subunit of several, distinct complexes involved in the repression or activation of transcription. The encoded protein can independently repress transcription and is targeted to replication foci throughout S phase by interacting directly with the N-terminus of DNA methyltransferase 1. During late S phase, histone deacetylase 2 is added to this complex, providing a means to deacetylate histones in transcriptionally inactive heterochromatin following replication. The encoded protein is also a component of the nucleosome acetyltransferase of H4 complex and interacts with the transcriptional corepressor tumor susceptibility gene 101 and the pro-apoptotic death-associated protein 6, among others. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA repair, chromatin organization, chromatin remodeling, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of double-strand break repair via homologous recombination, positive regulation of protein import into nucleus, regulation of DNA-templated transcription, regulation of apoptotic process, regulation of cell cycle, regulation of double-strand break repair, response to ethanol; MF: RNA polymerase II-specific DNA-binding transcription factor binding, protein binding, transcription corepressor activity; CC: NuA4 histone acetyltransferase complex, Swr1 complex, chromosome, cytoplasm, cytosol, nucleoplasm, nucleosome, nucleus, replication fork
Pathways: Chromatin modifying enzymes, Chromatin organization, HATs acetylate histones
UniProt: Q9NPF5
Entrez ID: 55929
|
Does Activation of TP53AIP1 in Hepatoma Cell Line causally result in response to virus?
| 0
| 1,210
|
Activation
|
TP53AIP1
|
response to virus
|
Hepatoma Cell Line
|
Gene: TP53AIP1 (tumor protein p53 regulated apoptosis inducing protein 1)
Type: protein-coding
Summary: This gene is specifically expressed in the thymus, and encodes a protein that is localized to the mitochondrion. The expression of this gene is inducible by p53, and it is thought to play an important role in mediating p53-dependent apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011].
Gene Ontology: BP: apoptotic process; CC: mitochondrial matrix, mitochondrion
Pathways: Apoptosis - Homo sapiens (human), DNA damage response, Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription, TP53 Regulates Transcription of Cell Death Genes, TP53 Regulates Transcription of Genes Involved in Cytochrome C Release, Transcriptional Regulation by TP53, miRNA regulation of DNA damage response, miRNA regulation of p53 pathway in prostate cancer, p53 pathway, p53 signaling pathway - Homo sapiens (human), p53 transcriptional gene network, p73 transcription factor network
UniProt: Q9HCN2
Entrez ID: 63970
|
Does Knockout of COX17 in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 0
| 2,033
|
Knockout
|
COX17
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: COX17 (cytochrome c oxidase copper chaperone COX17)
Type: protein-coding
Summary: Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be involved in the recruitment of copper to mitochondria for incorporation into the COX apoenzyme. This protein shares 92% amino acid sequence identity with mouse and rat Cox17 proteins. This gene is no longer considered to be a candidate gene for COX deficiency. A pseudogene COX17P has been found on chromosome 13. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: copper ion transport, generation of precursor metabolites and energy, heart development, mitochondrial cytochrome c oxidase assembly, positive regulation of cell population proliferation, positive regulation of cytochrome-c oxidase activity; MF: copper chaperone activity, copper ion binding, cuprous ion binding, enzyme activator activity, metal ion binding, protein binding; CC: cytoplasm, mitochondrial intermembrane space, mitochondrion
Pathways: Aerobic respiration and respiratory electron transport, Complex IV assembly, Copper homeostasis, Electron Transport Chain (OXPHOS system in mitochondria), IL-18 signaling pathway, Metabolism, Mitochondrial CIV Assembly, Mitochondrial protein import, Oxidative phosphorylation - Homo sapiens (human), Protein localization, Respiratory electron transport, Thermogenesis - Homo sapiens (human)
UniProt: Q14061
Entrez ID: 10063
|
Does Knockout of ZSCAN5A in Cancer Cell Line causally result in cell proliferation?
| 0
| 1,308
|
Knockout
|
ZSCAN5A
|
cell proliferation
|
Cancer Cell Line
|
Gene: ZSCAN5A (zinc finger and SCAN domain containing 5A)
Type: protein-coding
Summary: Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding, sequence-specific double-stranded DNA binding, zinc ion binding
Pathways:
UniProt: Q9BUG6
Entrez ID: 79149
|
Does Knockout of PSMD11 in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 230
|
Knockout
|
PSMD11
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: PSMD11 (proteasome 26S subunit, non-ATPase 11)
Type: protein-coding
Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the proteasome subunit S9 family that functions as a non-ATPase subunit of the 19S regulator and is phosphorylated by AMP-activated protein kinase. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012].
Gene Ontology: BP: proteasome assembly, proteasome-mediated ubiquitin-dependent protein catabolic process, stem cell differentiation, ubiquitin-dependent protein catabolic process; MF: protein binding, structural molecule activity; CC: cytoplasm, cytosol, extracellular region, ficolin-1-rich granule lumen, membrane, nucleoplasm, nucleus, proteasome accessory complex, proteasome complex, proteasome regulatory particle, proteasome regulatory particle, lid subcomplex, protein-containing complex, secretory granule lumen
Pathways: ABC transporter disorders, ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, AUF1 (hnRNP D0) binds and destabilizes mRNA, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Activation of NF-kappaB in B cells, Adaptive Immune System, Adherens junctions interactions, Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Antigen processing-Cross presentation, Antigen processing: Ubiquitination & Proteasome degradation, Apoptosis, Assembly of the pre-replicative complex, Asymmetric localization of PCP proteins, Autodegradation of Cdh1 by Cdh1:APC/C, Autodegradation of the E3 ubiquitin ligase COP1, Axon guidance, Beta-catenin independent WNT signaling, C-type lectin receptors (CLRs), CDK-mediated phosphorylation and removal of Cdc6, CLEC7A (Dectin-1) signaling, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cellular response to chemical stress, Cellular response to hypoxia, Cellular responses to stimuli, Cellular responses to stress, Circadian clock, Class I MHC mediated antigen processing & presentation, Co-inhibition by PD-1, Cross-presentation of soluble exogenous antigens (endosomes), Cyclin A:Cdk2-associated events at S phase entry, Cyclin E associated events during G1/S transition , Cytokine Signaling in Immune system, DNA Replication, DNA Replication Pre-Initiation, Dectin-1 mediated noncanonical NF-kB signaling, Defective CFTR causes cystic fibrosis, Degradation of AXIN, Degradation of CDH1, Degradation of CRY and PER proteins, Degradation of DVL, Degradation of GLI1 by the proteasome, Degradation of GLI2 by the proteasome, Degradation of beta-catenin by the destruction complex, Deubiquitination, Developmental Biology, Disease, Diseases of signal transduction by growth factor receptors and second messengers, Disorders of transmembrane transporters, Downstream TCR signaling, Downstream signaling events of B Cell Receptor (BCR), ER-Phagosome pathway, Epstein-Barr virus infection - Homo sapiens (human), FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, FCERI mediated NF-kB activation, Fc epsilon receptor (FCERI) signaling, Formation of paraxial mesoderm, G1/S DNA Damage Checkpoints, G1/S Transition, G2/M Checkpoints, G2/M Transition, GLI3 is processed to GLI3R by the proteasome, GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2, GSK3B-mediated proteasomal degradation of PD-L1(CD274), Gastrulation, Gene expression (Transcription), Generic Transcription Pathway, HIV Infection, Hedgehog 'off' state, Hedgehog 'on' state, Hedgehog ligand biogenesis, Hh mutants abrogate ligand secretion, Hh mutants are degraded by ERAD, Host Interactions of HIV factors, Huntington disease - Homo sapiens (human), Immune System, Infectious disease, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, Intracellular signaling by second messengers, KEAP1-NFE2L2 pathway, M Phase, MAPK family signaling cascades, MAPK1/MAPK3 signaling, MAPK6/MAPK4 signaling, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of polyamines, Metabolism of proteins, Mitotic Anaphase, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, NIK-->noncanonical NF-kB signaling, Neddylation, Negative regulation of NOTCH4 signaling, Nervous system development, Neutrophil degranulation, Nuclear events mediated by NFE2L2, Orc1 removal from chromatin, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, PCP/CE pathway, PIP3 activates AKT signaling, PTEN Regulation, Parkin-Ubiquitin Proteasomal System pathway, Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Post-translational protein modification, Prion disease - Homo sapiens (human), Programmed Cell Death, Proteasome - Homo sapiens (human), Proteasome Degradation, Proteasome assembly, RAF/MAP kinase cascade, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Regulation of APC/C activators between G1/S and early anaphase, Regulation of Apoptosis, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of PTEN stability and activity, Regulation of RAS by GAPs, Regulation of RUNX2 expression and activity, Regulation of RUNX3 expression and activity, Regulation of T cell activation by CD28 family, Regulation of activated PAK-2p34 by proteasome mediated degradation, Regulation of expression of SLITs and ROBOs, Regulation of mRNA stability by proteins that bind AU-rich elements, Regulation of mitotic cell cycle, Regulation of ornithine decarboxylase (ODC), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, S Phase, SCF(Skp2)-mediated degradation of p27/p21, SCF-beta-TrCP mediated degradation of Emi1, SPOP-mediated proteasomal degradation of PD-L1(CD274), Separation of Sister Chromatids, Signal Transduction, Signaling by Hedgehog, Signaling by Interleukins, Signaling by NOTCH, Signaling by NOTCH4, Signaling by ROBO receptors, Signaling by WNT, Signaling by the B Cell Receptor (BCR), Somitogenesis, Spinocerebellar ataxia - Homo sapiens (human), Stabilization of p53, Switching of origins to a post-replicative state, Synthesis of DNA, TCF dependent signaling in response to WNT, TCR signaling, TNFR2 non-canonical NF-kB pathway, The role of GTSE1 in G2/M progression after G2 checkpoint, Transcriptional regulation by RUNX1, Transcriptional regulation by RUNX2, Transcriptional regulation by RUNX3, Translation, Transport of small molecules, UCH proteinases, Ub-specific processing proteases, Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, Ubiquitin-dependent degradation of Cyclin D, VEGFA-VEGFR2 Signaling Pathway, Vif-mediated degradation of APOBEC3G, Viral Infection Pathways, Vpu mediated degradation of CD4, p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint, p53-Independent G1/S DNA Damage Checkpoint, proteasome complex
UniProt: O00231
Entrez ID: 5717
|
Does Knockout of RABGGTB in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 427
|
Knockout
|
RABGGTB
|
cell proliferation
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: RABGGTB (Rab geranylgeranyltransferase subunit beta)
Type: protein-coding
Summary: This gene encodes the beta-subunit of the enzyme Rab geranylgeranyl-transferase (RabGGTase), which belongs to the protein prenyltransferase family. RabGGTase catalyzes the post-translational addition of geranylgeranyl groups to C-terminal cysteine residues of Rab GTPases. Three small nucleolar RNA genes are present in the intronic regions of this gene. Alternately spliced transcript variants have been observed for this gene. A pseudogene associated with this gene is located on chromosome 3. [provided by RefSeq, Jan 2013].
Gene Ontology: BP: endoplasmic reticulum to Golgi vesicle-mediated transport, protein geranylgeranylation, protein modification process, visual perception; MF: Rab geranylgeranyltransferase activity, catalytic activity, metal ion binding, prenyltransferase activity, protein binding, protein geranylgeranyltransferase activity, protein prenyltransferase activity, small GTPase binding, transferase activity, zinc ion binding; CC: Rab-protein geranylgeranyltransferase complex, cytoplasm, cytosol, plasma membrane
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Metabolism of proteins, Post-translational protein modification, RAB geranylgeranylation, RNA Polymerase II Transcription, Signaling events mediated by PRL, TP53 Regulates Transcription of Cell Death Genes, TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain, Transcriptional Regulation by TP53
UniProt: P53611
Entrez ID: 5876
|
Does Knockout of AHCTF1 in Glioblastoma Cell Line causally result in cell proliferation?
| 1
| 906
|
Knockout
|
AHCTF1
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: AHCTF1 (AT-hook containing transcription factor 1)
Type: protein-coding
Summary: Predicted to enable DNA binding activity. Involved in nuclear pore complex assembly and regulation of cytokinesis. Located in nuclear membrane. Colocalizes with chromatin; kinetochore; and nuclear pore outer ring. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cell division, mRNA transport, nuclear pore complex assembly, nucleocytoplasmic transport, protein transport, regulation of cytokinesis; CC: chromatin, chromosome, chromosome, centromeric region, cytoplasm, cytosol, extracellular exosome, kinetochore, nuclear body, nuclear envelope, nuclear matrix, nuclear membrane, nuclear pore, nuclear pore outer ring, nucleoplasm, nucleus
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, EML4 and NUDC in mitotic spindle formation, Gastric Cancer Network 2, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, Nuclear Envelope (NE) Reassembly, Postmitotic nuclear pore complex (NPC) reformation, RHO GTPase Effectors, RHO GTPases Activate Formins, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q8WYP5
Entrez ID: 25909
|
Does Knockout of HES2 in Ovarian Cancer Cell Line causally result in cell proliferation?
| 0
| 699
|
Knockout
|
HES2
|
cell proliferation
|
Ovarian Cancer Cell Line
|
Gene: HES2 (hes family bHLH transcription factor 2)
Type: protein-coding
Summary: Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in anterior/posterior pattern specification; regulation of neurogenesis; and regulation of transcription by RNA polymerase II. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: anterior/posterior pattern specification, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of neurogenesis, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, double-stranded DNA binding, protein dimerization activity, sequence-specific double-stranded DNA binding; CC: chromatin, nucleus
Pathways: Human papillomavirus infection - Homo sapiens (human), Osteoblast differentiation
UniProt: Q9Y543
Entrez ID: 54626
|
Does Knockout of OR4E2 in Colonic Adenocarcinoma Cell Line causally result in response to bacteria?
| 0
| 1,480
|
Knockout
|
OR4E2
|
response to bacteria
|
Colonic Adenocarcinoma Cell Line
|
Gene: OR4E2 (olfactory receptor family 4 subfamily E member 2)
Type: protein-coding
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, detection of chemical stimulus involved in sensory perception of smell, sensory perception of smell, signal transduction; MF: G protein-coupled receptor activity, metal ion binding, odorant binding, olfactory receptor activity; CC: membrane, plasma membrane
Pathways: Olfactory transduction - Homo sapiens (human)
UniProt: A0A126GVR8
Entrez ID: 26686
|
Does Knockout of ARMC5 in Lung Cancer Cell Line causally result in response to radiation?
| 1
| 1,952
|
Knockout
|
ARMC5
|
response to radiation
|
Lung Cancer Cell Line
|
Gene: ARMC5 (armadillo repeat containing 5)
Type: protein-coding
Summary: This gene encodes a member of the ARM (armadillo/beta-catenin-like repeat) superfamily. The ARM repeat is a tandemly repeated sequence motif with approximately 40 amino acid long. This repeat is implicated in mediating protein-protein interactions. The encoded protein contains seven ARM repeats. Mutations in this gene are associated with primary bilateral macronodular adrenal hyperplasia, which is also known as ACTH-independent macronodular adrenal hyperplasia 2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014].
Gene Ontology: BP: CD4-positive, alpha-beta T cell differentiation, RNA polymerase II transcription initiation surveillance, T cell proliferation, adrenal cortex development, anatomical structure morphogenesis, defense response to virus, gastrulation, hemopoiesis, in utero embryonic development, mesoderm formation, proteasome-mediated ubiquitin-dependent protein catabolic process, regulation of steroid biosynthetic process, transcription by RNA polymerase II, transcription elongation by RNA polymerase II; MF: protein binding, ubiquitin-like ligase-substrate adaptor activity; CC: Cul3-RING ubiquitin ligase complex, chromatin, chromosome, cytoplasm, cytosol, focal adhesion, membrane, nucleoplasm, nucleus
Pathways: Cushing syndrome - Homo sapiens (human)
UniProt: Q96C12
Entrez ID: 79798
|
Does Knockout of PISD in acute lymphoblastic leukemia cell line causally result in cell proliferation?
| 1
| 1,957
|
Knockout
|
PISD
|
cell proliferation
|
acute lymphoblastic leukemia cell line
|
Gene: PISD (phosphatidylserine decarboxylase)
Type: protein-coding
Summary: The protein encoded by this gene catalyzes the conversion of phosphatidylserine to phosphatidylethanolamine in the inner mitochondrial membrane. The encoded protein is active in phospholipid metabolism and interorganelle trafficking of phosphatidylserine. [provided by RefSeq, May 2016].
Gene Ontology: BP: lipid droplet formation, lipid metabolic process, mitochondrial protein catabolic process, phosphatidylethanolamine biosynthetic process, phospholipid biosynthetic process, protein autoprocessing, regulation of mitochondrion organization; MF: carboxy-lyase activity, lyase activity, phosphatidylserine decarboxylase activity, protein binding; CC: Golgi apparatus, cytoplasm, cytosol, lipid droplet, membrane, mitochondrial inner membrane, mitochondrion, nucleus
Pathways: FOXA1 transcription factor network, Glycerolipids and Glycerophospholipids, Glycerophospholipid biosynthesis, Glycerophospholipid metabolism - Homo sapiens (human), Kennedy pathway from sphingolipids, Metabolism, Metabolism of lipids, Phospholipid Biosynthesis, Phospholipid metabolism, Synthesis of PE
UniProt: Q9UG56
Entrez ID: 23761
|
Does Activation of FGGY in T cell causally result in protein/peptide accumulation?
| 0
| 2,426
|
Activation
|
FGGY
|
protein/peptide accumulation
|
T cell
|
Gene: FGGY (FGGY carbohydrate kinase domain containing)
Type: protein-coding
Summary: This gene encodes a protein that phosphorylates carbohydrates such as ribulose, ribitol, and L-arabinitol. Genome-wide association studies in some populations have found an association between polymorphisms in this gene and sporadic amyotrophic lateral sclerosis, but studies of other populations have not been able to replicate this association. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013].
Gene Ontology: BP: carbohydrate metabolic process, carbohydrate phosphorylation, neuron cellular homeostasis, pentose metabolic process; MF: D-ribulokinase activity, kinase activity, phosphotransferase activity, alcohol group as acceptor, transferase activity
Pathways:
UniProt: Q96C11
Entrez ID: 55277
|
Does Knockout of SUGP1 in Bladder Carcinoma causally result in cell proliferation?
| 1
| 489
|
Knockout
|
SUGP1
|
cell proliferation
|
Bladder Carcinoma
|
Gene: SUGP1 (SURP and G-patch domain containing 1)
Type: protein-coding
Summary: SF4 is a member of the SURP family of splicing factors.[supplied by OMIM, Sep 2003].
Gene Ontology: BP: RNA processing, RNA splicing, mRNA processing; MF: RNA binding, mRNA binding, nucleic acid binding, protein binding; CC: nucleoplasm, nucleus, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, mRNA Processing, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q8IWZ8
Entrez ID: 57794
|
Does Knockout of KLC4 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 305
|
Knockout
|
KLC4
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: KLC4 (kinesin light chain 4)
Type: protein-coding
Summary: Predicted to be located in cytoplasm and microtubule. Predicted to be part of kinesin complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: kinesin binding, protein binding; CC: cytoplasm, cytoskeleton, kinesin complex, microtubule
Pathways: Adaptive Immune System, Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), COPI-dependent Golgi-to-ER retrograde traffic, Factors involved in megakaryocyte development and platelet production, Golgi-to-ER retrograde transport, Hemostasis, Huntington disease - Homo sapiens (human), Immune System, Intra-Golgi and retrograde Golgi-to-ER traffic, Kinesins, MHC class II antigen presentation, Membrane Trafficking, Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Prion disease - Homo sapiens (human), RHO GTPase Effectors, RHO GTPases activate KTN1, Salmonella infection - Homo sapiens (human), Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Vesicle-mediated transport
UniProt: Q9NSK0
Entrez ID: 89953
|
Does Knockout of SLC12A5 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 0
| 758
|
Knockout
|
SLC12A5
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: SLC12A5 (solute carrier family 12 member 5)
Type: protein-coding
Summary: K-Cl cotransporters are proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The protein encoded by this gene is an integral membrane K-Cl cotransporter that can function in either a net efflux or influx pathway, depending on the chemical concentration gradients of potassium and chloride. The encoded protein can act as a homomultimer, or as a heteromultimer with other K-Cl cotransporters, to maintain chloride homeostasis in neurons. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Sep 2008].
Gene Ontology: BP: ammonium transmembrane transport, cell volume homeostasis, chemical synaptic transmission, chloride ion homeostasis, chloride transmembrane transport, chloride transport, dendritic spine development, developmental process, hypotonic response, intracellular chloride ion homeostasis, intracellular pH reduction, learning, monoatomic ion transport, multicellular organism growth, postsynaptic neurotransmitter receptor diffusion trapping, potassium ion homeostasis, potassium ion import across plasma membrane, potassium ion transmembrane transport, potassium ion transport, regulation of postsynapse assembly, response to xenobiotic stimulus, thermosensory behavior, transmembrane transport; MF: ammonium channel activity, chloride transmembrane transporter activity, chloride:monoatomic cation symporter activity, metal ion binding, potassium:chloride symporter activity, protein kinase binding, symporter activity, transmembrane transporter activity; CC: cell periphery, cell projection, dendrite, dendrite membrane, glutamatergic synapse, membrane, neuron projection, neuronal cell body, perikaryon, plasma membrane, postsynaptic specialization membrane
Pathways: Cation-coupled Chloride cotransporters, GABAergic synapse - Homo sapiens (human), SLC-mediated transmembrane transport, SLC-mediated transport of inorganic anions, Transport of small molecules, mBDNF and proBDNF regulation of GABA neurotransmission
UniProt: Q9H2X9
Entrez ID: 57468
|
Does Activation of PIK3C2A in Hepatoma Cell Line causally result in response to virus?
| 1
| 1,210
|
Activation
|
PIK3C2A
|
response to virus
|
Hepatoma Cell Line
|
Gene: PIK3C2A (phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cell migration, clathrin coat assembly, endocytosis, epidermal growth factor receptor signaling pathway, exocytosis, insulin receptor signaling pathway, lipid metabolic process, membrane organization, phosphatidylinositol 3-kinase/protein kinase B signal transduction, phosphatidylinositol biosynthetic process, phosphatidylinositol phosphate biosynthetic process, phosphatidylinositol-3-phosphate biosynthetic process, phosphatidylinositol-mediated signaling, platelet-derived growth factor receptor signaling pathway, positive regulation of autophagy, positive regulation of cell migration involved in sprouting angiogenesis, vascular associated smooth muscle contraction; MF: 1-phosphatidylinositol-3-kinase activity, 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity, 1-phosphatidylinositol-4-phosphate 3-kinase activity, ATP binding, clathrin binding, kinase activity, nucleotide binding, phosphatidylinositol binding, transferase activity; CC: Golgi apparatus, clathrin-coated vesicle, cytoplasm, cytoplasmic vesicle, cytosol, extracellular exosome, membrane, nucleoplasm, nucleus, plasma membrane, trans-Golgi network, vesicle
Pathways: 3-phosphoinositide biosynthesis, Angiopoietin Like Protein 8 Regulatory Pathway, Clathrin-mediated endocytosis, DNA damage response (only ATM dependent), Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, Glioblastoma signaling pathways, Golgi Associated Vesicle Biogenesis, Inositol phosphate metabolism - Homo sapiens (human), Insulin Signaling, Integrins in angiogenesis, Joubert syndrome, Membrane Trafficking, Metabolism, Metabolism of lipids, Microglia Pathogen Phagocytosis Pathway, Osteoblast differentiation, PI Metabolism, Phosphatidylinositol Phosphate Metabolism, Phosphatidylinositol signaling system - Homo sapiens (human), Phospholipid metabolism, Regulation of Actin Cytoskeleton, Salmonella infection - Homo sapiens (human), Synthesis of PIPs at the Golgi membrane, Synthesis of PIPs at the early endosome membrane, Synthesis of PIPs at the late endosome membrane, Synthesis of PIPs at the plasma membrane, Vesicle-mediated transport, superpathway of inositol phosphate compounds, trans-Golgi Network Vesicle Budding
UniProt: O00443
Entrez ID: 5286
|
Does Knockout of CADPS2 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,576
|
Knockout
|
CADPS2
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: CADPS2 (calcium dependent secretion activator 2)
Type: protein-coding
Summary: This gene encodes a member of the calcium-dependent activator of secretion (CAPS) protein family, which are calcium binding proteins that regulate the exocytosis of synaptic and dense-core vesicles in neurons and neuroendocrine cells. Mutations in this gene may contribute to autism susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009].
Gene Ontology: BP: cellular response to starvation, dense core granule exocytosis, exocytosis, hematopoietic stem cell homeostasis, positive regulation of exocytosis, protein transport, synaptic vesicle exocytosis, synaptic vesicle priming; MF: lipid binding, metal ion binding; CC: cell projection, centrosome, ciliary basal body, cilium, cytoplasm, cytoplasmic vesicle, cytoplasmic vesicle membrane, cytoskeleton, glutamatergic synapse, membrane, nucleoplasm, parallel fiber to Purkinje cell synapse, postsynaptic membrane, presynapse, presynaptic membrane, synapse
Pathways:
UniProt: Q86UW7
Entrez ID: 93664
|
Does Knockout of NUP85 in Bladder Carcinoma causally result in cell proliferation?
| 1
| 489
|
Knockout
|
NUP85
|
cell proliferation
|
Bladder Carcinoma
|
Gene: NUP85 (nucleoporin 85)
Type: protein-coding
Summary: This gene encodes a protein component of the Nup107-160 subunit of the nuclear pore complex. Nuclear pore complexes are embedded in the nuclear envelope and promote bidirectional transport of macromolecules between the cytoplasm and nucleus. The encoded protein can also bind to the C-terminus of chemokine (C-C motif) receptor 2 (CCR2) and promote chemotaxis of monocytes, thereby participating in the inflammatory response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014].
Gene Ontology: BP: chemotaxis, lamellipodium assembly, mRNA export from nucleus, mRNA transport, macrophage chemotaxis, nephron development, nucleocytoplasmic transport, positive regulation of DNA-templated transcription, protein import into nucleus, protein transport; MF: protein binding, structural constituent of nuclear pore; CC: actin cytoskeleton, chromosome, chromosome, centromeric region, ciliary basal body, cytoplasm, cytoskeleton, cytosol, kinetochore, membrane, nuclear envelope, nuclear membrane, nuclear pore, nuclear pore outer ring, nucleoplasm, nucleus, spindle
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Amyotrophic lateral sclerosis - Homo sapiens (human), Antiviral mechanism by IFN-stimulated genes, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Cytokine Signaling in Immune system, Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC), Disease, Disorders of transmembrane transporters, EML4 and NUDC in mitotic spindle formation, Export of Viral Ribonucleoproteins from Nucleus, Gene Silencing by RNA, Gene expression (Transcription), Glucose metabolism, Glycolysis, HCMV Early Events, HCMV Infection, HCMV Late Events, HIV Infection, HIV Life Cycle, Host Interactions of HIV factors, IP3 and IP4 transport between cytosol and nucleus, IP6 and IP7 transport between cytosol and nucleus, IPs transport between nucleus and cytosol, ISG15 antiviral mechanism, Immune System, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, Inositol phosphate metabolism, Integrated breast cancer pathway, Interactions of Rev with host cellular proteins, Interactions of Vpr with host cellular proteins, Interferon Signaling, Late Phase of HIV Life Cycle, M Phase, Metabolism, Metabolism of RNA, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of non-coding RNA, Metabolism of proteins, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Prophase, Mitotic Spindle Checkpoint, NEP/NS2 Interacts with the Cellular Export Machinery, NS1 Mediated Effects on Host Pathways, Nuclear Envelope (NE) Reassembly, Nuclear Envelope Breakdown, Nuclear Pore Complex (NPC) Disassembly, Nuclear import of Rev protein, Post-translational protein modification, Postmitotic nuclear pore complex (NPC) reformation, Processing of Capped Intron-Containing Pre-mRNA, RHO GTPase Effectors, RHO GTPases Activate Formins, RNA transport - Homo sapiens (human), Regulation of Glucokinase by Glucokinase Regulatory Protein, Regulation of HSF1-mediated heat shock response, Resolution of Sister Chromatid Cohesion, Rev-mediated nuclear export of HIV RNA, SARS-CoV Infections, SARS-CoV-2 Infection, SARS-CoV-2 activates/modulates innate and adaptive immune responses, SARS-CoV-2-host interactions, SLC transporter disorders, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, SUMOylation of DNA replication proteins, SUMOylation of RNA binding proteins, SUMOylation of SUMOylation proteins, SUMOylation of chromatin organization proteins, SUMOylation of ubiquitinylation proteins, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Transcriptional regulation by small RNAs, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNA derived from an Intron-Containing Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, Transport of Ribonucleoproteins into the Host Nucleus, Transport of the SLBP Dependant Mature mRNA, Transport of the SLBP independent Mature mRNA, Viral Infection Pathways, Viral Messenger RNA Synthesis, Vpr-mediated nuclear import of PICs, snRNP Assembly, tRNA processing, tRNA processing in the nucleus
UniProt: Q9BW27
Entrez ID: 79902
|
Does Knockout of RSRC2 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 220
|
Knockout
|
RSRC2
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: RSRC2 (arginine and serine rich coiled-coil 2)
Type: protein-coding
Summary: Enables RNA binding activity. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: RNA binding, protein binding
Pathways:
UniProt: Q7L4I2
Entrez ID: 65117
|
Does Knockout of ELF4 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,658
|
Knockout
|
ELF4
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: ELF4 (E74 like ETS transcription factor 4)
Type: protein-coding
Summary: The protein encoded by this gene is a transcriptional activator that binds and activates the promoters of the CSF2, IL3, IL8, and PRF1 genes. The encoded protein is involved in natural killer cell development and function, innate immunity, and induction of cell cycle arrest in naive CD8+ cells. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Jan 2010].
Gene Ontology: BP: NK T cell proliferation, cell differentiation, natural killer cell proliferation, negative regulation of inflammatory response, negative regulation of interleukin-1 beta production, negative regulation of interleukin-6 production, negative regulation of tumor necrosis factor production, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: PML body, chromatin, nuclear body, nucleoplasm, nucleus
Pathways: TYROBP causal network in microglia
UniProt: Q99607
Entrez ID: 2000
|
Does Knockout of POLN in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,329
|
Knockout
|
POLN
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: POLN (DNA polymerase nu)
Type: protein-coding
Summary: This gene encodes a DNA polymerase type-A family member. The encoded protein plays a role in DNA repair and homologous recombination. This gene shares its 5' exons with some transcripts from overlapping GeneID: 79441, which encodes an augmentin-like protein complex subunit. [provided by RefSeq, Dec 2014].
Gene Ontology: BP: DNA damage response, DNA repair, DNA replication, DNA synthesis involved in DNA repair, DNA-templated DNA replication, double-strand break repair, double-strand break repair via homologous recombination, interstrand cross-link repair, translesion synthesis; MF: DNA binding, DNA polymerase activity, DNA-directed DNA polymerase activity, cyclin binding, nucleic acid binding, nucleotidyltransferase activity, protein binding, transferase activity; CC: nucleolus, nucleoplasm, nucleus
Pathways: DNA Repair, Fanconi Anemia Pathway, Fanconi anemia pathway - Homo sapiens (human)
UniProt: Q7Z5Q5
Entrez ID: 353497
|
Does Knockout of E4F1 in Renal Cancer Cell Line causally result in cell proliferation?
| 1
| 319
|
Knockout
|
E4F1
|
cell proliferation
|
Renal Cancer Cell Line
|
Gene: E4F1 (E4F transcription factor 1)
Type: protein-coding
Summary: The zinc finger protein encoded by this gene is one of several cellular transcription factors whose DNA-binding activities are regulated through the action of adenovirus E1A. A 50-kDa amino-terminal product is generated from the full-length protein through proteolytic cleavage. The protein is differentially regulated by E1A-induced phosphorylation. The full-length gene product represses transcription from the E4 promoter in the absence of E1A, while the 50-kDa form acts as a transcriptional activator in its presence. Alternative splicing results in multiple transcripts encoding different proteins. [provided by RefSeq, Jan 2014].
Gene Ontology: BP: DNA replication, cell division, negative regulation of transcription by RNA polymerase II, positive regulation of transcription by RNA polymerase II, protein ubiquitination, regulation of cell cycle, regulation of cell cycle process, regulation of mitotic cell cycle, embryonic, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, cAMP response element binding, metal ion binding, protein binding, transferase activity, ubiquitin protein ligase activity, zinc ion binding; CC: cytoplasm, nuclear body, nucleoplasm, nucleus, spindle
Pathways: p53 pathway
UniProt: Q66K89
Entrez ID: 1877
|
Does Knockout of SCNN1G in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 815
|
Knockout
|
SCNN1G
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: SCNN1G (sodium channel epithelial 1 subunit gamma)
Type: protein-coding
Summary: Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the gamma subunit, and mutations in this gene have been associated with Liddle syndrome. [provided by RefSeq, Apr 2009].
Gene Ontology: BP: cellular response to acidic pH, cellular response to aldosterone, cellular response to vasopressin, intracellular sodium ion homeostasis, monoatomic ion transmembrane transport, monoatomic ion transport, multicellular organismal-level water homeostasis, regulation of blood pressure, sensory perception of salty taste, sensory perception of sour taste, sodium ion homeostasis, sodium ion import across plasma membrane, sodium ion transmembrane transport, sodium ion transport; MF: WW domain binding, ligand-gated sodium channel activity, monoatomic ion channel activity, protein binding, sodium channel activity; CC: apical plasma membrane, external side of plasma membrane, extracellular exosome, membrane, nucleoplasm, plasma membrane, sodium channel complex
Pathways: Aldosterone-regulated sodium reabsorption - Homo sapiens (human), Amiloride Action Pathway, Bendroflumethiazide Action Pathway, Blue diaper syndrome, Bumetanide Action Pathway, Chlorothiazide Action Pathway, Chlorthalidone Action Pathway, Cyclothiazide Action Pathway, Cystinuria, Eplerenone Action Pathway, Ethacrynic Acid Action Pathway, Furosemide Action Pathway, Glucose Transporter Defect (SGLT2), Hartnup Disorder, Hydrochlorothiazide Action Pathway, Hydroflumethiazide Action Pathway, Iminoglycinuria, Indapamide Action Pathway, Ion channel transport, Kidney Function, Lysinuric Protein Intolerance, Lysinuric protein intolerance (LPI), Methyclothiazide Action Pathway, Metolazone Action Pathway, Polythiazide Action Pathway, Quinethazone Action Pathway, Sensory Perception, Sensory perception of salty taste, Sensory perception of taste, Spironolactone Action Pathway, Stimuli-sensing channels, Taste transduction - Homo sapiens (human), Torsemide Action Pathway, Transport of small molecules, Triamterene Action Pathway, Trichlormethiazide Action Pathway
UniProt: P51170
Entrez ID: 6340
|
Does Knockout of SUPT16H in T-lymphoma cell line causally result in cell proliferation?
| 1
| 478
|
Knockout
|
SUPT16H
|
cell proliferation
|
T-lymphoma cell line
|
Gene: SUPT16H (SPT16 homolog, facilitates chromatin remodeling subunit)
Type: protein-coding
Summary: Transcription of protein-coding genes can be reconstituted on naked DNA with only the general transcription factors and RNA polymerase II. However, this minimal system cannot transcribe DNA packaged into chromatin, indicating that accessory factors may facilitate access to DNA. One such factor, FACT (facilitates chromatin transcription), interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT is composed of an 80 kDa subunit and a 140 kDa subunit; this gene encodes the 140 kDa subunit. [provided by RefSeq, Feb 2009].
Gene Ontology: BP: DNA damage response, DNA repair, DNA replication, nucleosome assembly, nucleosome disassembly, positive regulation of DNA-templated transcription, elongation, transcription by RNA polymerase II, transcription elongation by RNA polymerase II; MF: RNA binding, nucleosome binding, protein binding; CC: FACT complex, chromosome, nucleoplasm, nucleus, transcription elongation factor complex
Pathways: Disease, Formation of HIV elongation complex in the absence of HIV Tat, Formation of HIV-1 elongation complex containing HIV-1 Tat, Formation of RNA Pol II elongation complex , Gene expression (Transcription), Generic Transcription Pathway, HIV Infection, HIV Life Cycle, HIV Transcription Elongation, HIV elongation arrest and recovery, Infectious disease, Late Phase of HIV Life Cycle, Pausing and recovery of HIV elongation, Pausing and recovery of Tat-mediated HIV elongation, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, TP53 Regulates Transcription of DNA Repair Genes, Tat-mediated HIV elongation arrest and recovery, Tat-mediated elongation of the HIV-1 transcript, Transcription of the HIV genome, Transcriptional Regulation by TP53, Viral Infection Pathways
UniProt: Q9Y5B9
Entrez ID: 11198
|
Does Knockout of SYNJ2 in Breast Cancer Cell Line causally result in cell proliferation?
| 0
| 235
|
Knockout
|
SYNJ2
|
cell proliferation
|
Breast Cancer Cell Line
|
Gene: SYNJ2 (synaptojanin 2)
Type: protein-coding
Summary: The gene is a member of the inositol-polyphosphate 5-phosphatase family. The encoded protein interacts with the ras-related C3 botulinum toxin substrate 1, which causes translocation of the encoded protein to the plasma membrane where it inhibits clathrin-mediated endocytosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010].
Gene Ontology: BP: lipid metabolic process, membrane organization, phosphatidylinositol biosynthetic process, phosphatidylinositol dephosphorylation, phosphatidylinositol-3-phosphate biosynthetic process, synaptic vesicle endocytosis; MF: RNA binding, hydrolase activity, inositol-1,4,5-trisphosphate 5-phosphatase activity, nucleic acid binding, phosphatase activity, phosphatidylinositol phosphate 4-phosphatase activity, phosphatidylinositol phosphate phosphatase activity, phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity, phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity, phosphatidylinositol-3-phosphate phosphatase activity, phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity, protein binding; CC: cell projection, cytoplasm, cytoskeleton, cytosol, membrane, membrane raft, perinuclear region of cytoplasm, plasma membrane, presynapse, synapse
Pathways: 1D-<i>myo</i>-inositol hexakisphosphate biosynthesis II (mammalian), 3-phosphoinositide degradation, Clathrin-mediated endocytosis, D-<i>myo</i>-inositol (1,3,4)-trisphosphate biosynthesis, D-<i>myo</i>-inositol (1,4,5)-trisphosphate degradation, Inositol phosphate metabolism - Homo sapiens (human), Membrane Trafficking, Metabolism, Metabolism of lipids, PI Metabolism, Phosphatidylinositol signaling system - Homo sapiens (human), Phospholipid metabolism, Synthesis of PIPs at the plasma membrane, Vesicle-mediated transport, endocytotic role of ndk phosphins and dynamin, superpathway of D-<i>myo</i>-inositol (1,4,5)-trisphosphate metabolism, superpathway of inositol phosphate compounds
UniProt: O15056
Entrez ID: 8871
|
Does Knockout of REL in Endometrial Cancer Cell Line causally result in cell proliferation?
| 0
| 758
|
Knockout
|
REL
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: REL (REL proto-oncogene, NF-kB subunit)
Type: protein-coding
Summary: This gene encodes a protein that belongs to the Rel homology domain/immunoglobulin-like fold, plexin, transcription factor (RHD/IPT) family. Members of this family regulate genes involved in apoptosis, inflammation, the immune response, and oncogenic processes. This proto-oncogene plays a role in the survival and proliferation of B lymphocytes. Mutation or amplification of this gene is associated with B-cell lymphomas, including Hodgkin's lymphoma. Single nucleotide polymorphisms in this gene are associated with susceptibility to ulcerative colitis and rheumatoid arthritis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014].
Gene Ontology: BP: canonical NF-kappaB signal transduction, inflammatory response, innate immune response, negative regulation of cytokine production, negative regulation of gene expression, negative regulation of interferon-beta production, non-canonical NF-kappaB signal transduction, positive regulation of canonical NF-kappaB signal transduction, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, response to cytokine; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, protein binding, sequence-specific DNA binding; CC: NF-kappaB complex, chromatin, cytoplasm, cytosol, nucleoplasm, nucleus
Pathways: 16p11.2 proximal deletion syndrome, Atypical NF-kappaB pathway, B Cell Receptor Signaling Pathway, Canonical NF-KB pathway, Chromosomal and microsatellite instability in colorectal cancer, Ebola Virus Pathway on Host, Head and Neck Squamous Cell Carcinoma, IL-1 signaling pathway, IL-18 signaling pathway, IL1, Interferon type I signaling pathways, Leptin signaling pathway, Modulators of TCR signaling and T cell activation, Photodynamic therapy-induced NF-kB survival signaling, RANKL, Ras signaling, Ras signaling pathway - Homo sapiens (human), Regulation of Androgen receptor activity, STING pathway in Kawasaki-like disease and COVID-19, T-cell receptor (TCR) signaling pathway, TNF-alpha signaling pathway, TNFalpha, Toll-like Receptor Signaling related to MyD88, Transcriptional misregulation in cancer - Homo sapiens (human), Viral carcinogenesis - Homo sapiens (human), miRNAs involvement in the immune response in sepsis
UniProt: Q04864
Entrez ID: 5966
|
Does Knockout of WDR1 in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 1,311
|
Knockout
|
WDR1
|
cell proliferation
|
Oral Squamous Cell Carcinoma Cell Line
|
Gene: WDR1 (WD repeat domain 1)
Type: protein-coding
Summary: This gene encodes a protein containing 9 WD repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, mostly including a trp-asp at the C-terminal end. WD domains are involved in protein-protein interactions. The encoded protein may help induce the disassembly of actin filaments. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: actin cytoskeleton organization, actin filament depolymerization, actin filament fragmentation, apical junction assembly, cortical cytoskeleton organization, establishment of planar polarity of follicular epithelium, locomotion, maintenance of epithelial cell apical/basal polarity, neutrophil mediated immunity, neutrophil migration, platelet formation, positive regulation of actin filament depolymerization, regulation of actin filament depolymerization, regulation of cell shape, regulation of oligodendrocyte differentiation, regulation of ventricular cardiac muscle cell membrane repolarization, sarcomere organization, sensory perception of sound; MF: actin binding, actin filament binding, protein binding; CC: actin cytoskeleton, anchoring junction, cell junction, cell projection, cell-cell junction, cortical actin cytoskeleton, cytoplasm, cytoskeleton, cytosol, extracellular exosome, extracellular region, glutamatergic synapse, plasma membrane, podosome, synapse
Pathways: Hemostasis, Hypertrophy Model, Platelet activation, signaling and aggregation, Platelet degranulation , Response to elevated platelet cytosolic Ca2+, TCR
UniProt: O75083
Entrez ID: 9948
|
Does Knockout of NAGS in Hepatoma Cell Line causally result in response to virus?
| 0
| 2,437
|
Knockout
|
NAGS
|
response to virus
|
Hepatoma Cell Line
|
Gene: NAGS (N-acetylglutamate synthase)
Type: protein-coding
Summary: The N-acetylglutamate synthase gene encodes a mitochondrial enzyme that catalyzes the formation of N-acetylglutamate (NAG) from glutamate and acetyl coenzyme-A. NAG is a cofactor of carbamyl phosphate synthetase I (CPSI), the first enzyme of the urea cycle in mammals. This gene may regulate ureagenesis by altering NAG availability and, thereby, CPSI activity. Deficiencies in N-acetylglutamate synthase have been associated with hyperammonemia. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: L-arginine biosynthetic process, glutamate metabolic process, urea cycle; MF: L-glutamate N-acetyltransferase activity, acyltransferase activity, acyltransferase activity, transferring groups other than amino-acyl groups, transferase activity; CC: mitochondrial matrix, mitochondrion
Pathways: Arginine biosynthesis - Homo sapiens (human), Metabolism, Metabolism of amino acids and derivatives, Urea cycle
UniProt: Q8N159
Entrez ID: 162417
|
Does Knockout of WDR1 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 69
|
Knockout
|
WDR1
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: WDR1 (WD repeat domain 1)
Type: protein-coding
Summary: This gene encodes a protein containing 9 WD repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, mostly including a trp-asp at the C-terminal end. WD domains are involved in protein-protein interactions. The encoded protein may help induce the disassembly of actin filaments. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: actin cytoskeleton organization, actin filament depolymerization, actin filament fragmentation, apical junction assembly, cortical cytoskeleton organization, establishment of planar polarity of follicular epithelium, locomotion, maintenance of epithelial cell apical/basal polarity, neutrophil mediated immunity, neutrophil migration, platelet formation, positive regulation of actin filament depolymerization, regulation of actin filament depolymerization, regulation of cell shape, regulation of oligodendrocyte differentiation, regulation of ventricular cardiac muscle cell membrane repolarization, sarcomere organization, sensory perception of sound; MF: actin binding, actin filament binding, protein binding; CC: actin cytoskeleton, anchoring junction, cell junction, cell projection, cell-cell junction, cortical actin cytoskeleton, cytoplasm, cytoskeleton, cytosol, extracellular exosome, extracellular region, glutamatergic synapse, plasma membrane, podosome, synapse
Pathways: Hemostasis, Hypertrophy Model, Platelet activation, signaling and aggregation, Platelet degranulation , Response to elevated platelet cytosolic Ca2+, TCR
UniProt: O75083
Entrez ID: 9948
|
Does Knockout of ARHGEF18 in Breast Cancer Cell Line causally result in cell proliferation?
| 0
| 235
|
Knockout
|
ARHGEF18
|
cell proliferation
|
Breast Cancer Cell Line
|
Gene: ARHGEF18 (Rho/Rac guanine nucleotide exchange factor 18)
Type: protein-coding
Summary: Rho GTPases are GTP binding proteins that regulate a wide spectrum of cellular functions. These cellular processes include cytoskeletal rearrangements, gene transcription, cell growth and motility. Activation of Rho GTPases is under the direct control of guanine nucleotide exchange factors (GEFs). The protein encoded by this gene is a guanine nucleotide exchange factor and belongs to the Rho GTPase GEF family. Family members share a common feature, a Dbl (DH) homology domain followed by a pleckstrin (PH) homology domain. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Nov 2018].
Gene Ontology: BP: actin cytoskeleton organization, negative regulation of stress fiber assembly, protein localization to cell-cell junction, regulation of Rho protein signal transduction, regulation of cell shape, small GTPase-mediated signal transduction; MF: guanyl-nucleotide exchange factor activity, metal ion binding, protein binding, zinc ion binding; CC: apical part of cell, apical plasma membrane, cell junction, cytoplasm, cytoskeleton, cytosol, extracellular exosome, membrane, plasma membrane
Pathways: Cell death signalling via NRAGE, NRIF and NADE, Death Receptor Signaling, G alpha (12/13) signalling events, GPCR downstream signalling, NRAGE signals death through JNK, RAC1 GTPase cycle, RHO GTPase cycle, RHOA GTPase cycle, Regulation of RhoA activity, Signal Transduction, Signaling by GPCR, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by TGF-beta Receptor Complex, Signaling by TGFB family members, TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition), Tight junction - Homo sapiens (human), p75 NTR receptor-mediated signalling
UniProt: Q6ZSZ5
Entrez ID: 23370
|
Does Knockout of PAXBP1 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 1,736
|
Knockout
|
PAXBP1
|
response to chemicals
|
Colonic Adenocarcinoma Cell Line
|
Gene: PAXBP1 (PAX3 and PAX7 binding protein 1)
Type: protein-coding
Summary: This gene encodes a protein that may bind to GC-rich DNA sequences, which suggests its involvement in the regulation of transcription. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jun 2009]
Gene Ontology: BP: mRNA splicing, via spliceosome, muscle organ development, positive regulation of myoblast proliferation, positive regulation of transcription by RNA polymerase II, regulation of skeletal muscle satellite cell proliferation, transcription by RNA polymerase II; MF: DNA binding, histone methyltransferase binding; CC: cytosol, nucleus
Pathways:
UniProt: Q9Y5B6
Entrez ID: 94104
|
Does Knockout of ARID1A in Hepatoma Cell Line causally result in response to virus?
| 1
| 2,437
|
Knockout
|
ARID1A
|
response to virus
|
Hepatoma Cell Line
|
Gene: ARID1A (AT-rich interaction domain 1A)
Type: protein-coding
Summary: This gene encodes a member of the SWI/SNF family, whose members have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. It possesses at least two conserved domains that could be important for its function. First, it has a DNA-binding domain that can specifically bind an AT-rich DNA sequence known to be recognized by a SNF/SWI complex at the beta-globin locus. Second, the C-terminus of the protein can stimulate glucocorticoid receptor-dependent transcriptional activation. It is thought that the protein encoded by this gene confers specificity to the SNF/SWI complex and may recruit the complex to its targets through either protein-DNA or protein-protein interactions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: chromatin organization, chromatin remodeling, nervous system development, nucleosome disassembly, positive regulation of DNA-templated transcription, positive regulation of T cell differentiation, positive regulation of cell differentiation, positive regulation of double-strand break repair, positive regulation of myoblast differentiation, positive regulation of stem cell population maintenance, regulation of G0 to G1 transition, regulation of G1/S transition of mitotic cell cycle, regulation of mitotic metaphase/anaphase transition, regulation of nucleotide-excision repair, regulation of transcription by RNA polymerase II, transcription initiation-coupled chromatin remodeling; MF: DNA binding, nuclear receptor binding, nucleosome binding, protein binding, transcription coactivator activity; CC: SWI/SNF complex, bBAF complex, brahma complex, chromatin, nBAF complex, npBAF complex, nucleoplasm, nucleus
Pathways: Hepatocellular carcinoma - Homo sapiens (human), Pathways affected in adenoid cystic carcinoma, Thermogenesis, Thermogenesis - Homo sapiens (human), Tumor suppressor activity of SMARCB1, chromatin remodeling by hswi/snf atp-dependent complexes, the information processing pathway at the ifn beta enhancer
UniProt: O14497
Entrez ID: 8289
|
Does Knockout of DCTN4 in Glioblastoma Cell Line causally result in cell proliferation?
| 1
| 519
|
Knockout
|
DCTN4
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: DCTN4 (dynactin subunit 4)
Type: protein-coding
Summary: Enables protein N-terminus binding activity. Located in centrosome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: cell cortex, centrosome, cytoplasm, cytoplasmic dynein complex, cytoskeleton, cytosol, dynactin complex, focal adhesion, kinetochore, nucleus, sarcomere, spindle pole, stress fiber
Pathways: Adaptive Immune System, Amyotrophic lateral sclerosis - Homo sapiens (human), Asparagine N-linked glycosylation, COPI-independent Golgi-to-ER retrograde traffic, COPI-mediated anterograde transport, Cellular responses to stimuli, Cellular responses to stress, ER to Golgi Anterograde Transport, Golgi-to-ER retrograde transport, HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand, Huntington disease - Homo sapiens (human), Immune System, Intra-Golgi and retrograde Golgi-to-ER traffic, MHC class II antigen presentation, Membrane Trafficking, Metabolism of proteins, Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Post-translational protein modification, Salmonella infection - Homo sapiens (human), Transport to the Golgi and subsequent modification, Vasopressin-regulated water reabsorption - Homo sapiens (human), Vesicle-mediated transport
UniProt: Q9UJW0
Entrez ID: 51164
|
Does Knockout of HSPA9 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 220
|
Knockout
|
HSPA9
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: HSPA9 (heat shock protein family A (Hsp70) member 9)
Type: protein-coding
Summary: This gene encodes a member of the heat shock protein 70 gene family. The encoded protein is primarily localized to the mitochondria but is also found in the endoplasmic reticulum, plasma membrane and cytoplasmic vesicles. This protein is a heat-shock cognate protein. This protein plays a role in cell proliferation, stress response and maintenance of the mitochondria. A pseudogene of this gene is found on chromosome 2.[provided by RefSeq, May 2010].
Gene Ontology: BP: calcium import into the mitochondrion, erythrocyte differentiation, inner mitochondrial membrane organization, intracellular protein transport, iron-sulfur cluster assembly, negative regulation of apoptotic process, negative regulation of erythrocyte differentiation, negative regulation of hematopoietic stem cell differentiation, negative regulation of hemopoiesis, positive regulation of apoptotic process, protein export from nucleus, protein folding, protein refolding, regulation of erythrocyte differentiation; MF: ATP binding, ATP hydrolysis activity, ATP-dependent protein folding chaperone, RNA binding, enzyme binding, heat shock protein binding, hydrolase activity, nucleotide binding, protein binding, protein folding chaperone, ubiquitin protein ligase binding, unfolded protein binding; CC: MIB complex, SAM complex, TIM23 mitochondrial import inner membrane translocase complex, cytoplasm, extracellular exosome, focal adhesion, mitochondrial inner membrane, mitochondrial matrix, mitochondrial nucleoid, mitochondrion, nucleolus, nucleus
Pathways: Aerobic respiration and respiratory electron transport, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Complex I biogenesis, Complex III assembly, Cristae formation, Cytokine Signaling in Immune system, Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation, Immune System, Interleukin-12 family signaling, Interleukin-12 signaling, Metabolism, Metabolism of proteins, Mitochondrial biogenesis, Mitochondrial protein degradation, Mitochondrial protein import, Mitochondrial unfolded protein response (UPRmt), Organelle biogenesis and maintenance, Parkin-Ubiquitin Proteasomal System pathway, Protein localization, RNA degradation - Homo sapiens (human), Regulation of HSF1-mediated heat shock response, Respiratory electron transport, Signaling by Interleukins, Tuberculosis - Homo sapiens (human)
UniProt: P38646
Entrez ID: 3313
|
Does Knockout of CEACAM6 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 427
|
Knockout
|
CEACAM6
|
cell proliferation
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: CEACAM6 (CEA cell adhesion molecule 6)
Type: protein-coding
Summary: This gene encodes a protein that belongs to the carcinoembryonic antigen (CEA) family whose members are glycosyl phosphatidyl inositol (GPI) anchored cell surface glycoproteins. Members of this family play a role in cell adhesion and are widely used as tumor markers in serum immunoassay determinations of carcinoma. This gene affects the sensitivity of tumor cells to adenovirus infection. The protein encoded by this gene acts as a receptor for adherent-invasive E. coli adhesion to the surface of ileal epithelial cells in patients with Crohn's disease. This gene is clustered with genes and pseudogenes of the cell adhesion molecules subgroup of the CEA family on chromosome 19. [provided by RefSeq, Apr 2014].
Gene Ontology: BP: apoptotic process, cell adhesion, heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules, homophilic cell adhesion via plasma membrane adhesion molecules, negative regulation of anoikis, positive regulation of cell migration, positive regulation of cell population proliferation, positive regulation of endothelial cell-matrix adhesion via fibronectin, positive regulation of heterotypic cell-cell adhesion; MF: identical protein binding, protein binding, protein heterodimerization activity; CC: apical plasma membrane, azurophil granule membrane, cell surface, extracellular space, membrane, plasma membrane, side of membrane
Pathways: Cell surface interactions at the vascular wall, Extracellular matrix organization, Fibronectin matrix formation, Hemostasis, Immune System, Innate Immune System, Neutrophil degranulation
UniProt: P40199
Entrez ID: 4680
|
Does Knockout of RRP7A in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 1,311
|
Knockout
|
RRP7A
|
cell proliferation
|
Oral Squamous Cell Carcinoma Cell Line
|
Gene: RRP7A (ribosomal RNA processing 7 homolog A)
Type: protein-coding
Summary: Enables RNA binding activity. Predicted to be involved in rRNA processing and ribosomal small subunit assembly. Predicted to act upstream of or within blastocyst formation. Predicted to be located in nucleoplasm. Predicted to be part of CURI complex and UTP-C complex. Implicated in primary autosomal recessive microcephaly. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: blastocyst formation, cilium disassembly, protein localization to nucleolus, rRNA processing, ribosomal small subunit assembly, ribosomal small subunit biogenesis, ribosome biogenesis; MF: RNA binding, nucleic acid binding, protein binding; CC: CURI complex, UTP-C complex, cell junction, cell projection, centrosome, cilium, cytoplasm, cytoskeleton, nucleolus, nucleoplasm, nucleus, small-subunit processome
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Ribosome biogenesis in eukaryotes - Homo sapiens (human), rRNA modification in the nucleus and cytosol, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9Y3A4
Entrez ID: 27341
|
Does Knockout of CDYL in Cervical Adenocarcinoma Cell Line causally result in protein/peptide accumulation?
| 1
| 2,404
|
Knockout
|
CDYL
|
protein/peptide accumulation
|
Cervical Adenocarcinoma Cell Line
|
Gene: CDYL (chromodomain Y like)
Type: protein-coding
Summary: Chromodomain Y is a primate-specific Y-chromosomal gene family expressed exclusively in the testis and implicated in infertility. Although the Y-linked genes are testis-specific, this autosomal gene is ubiquitously expressed. The Y-linked genes arose by retrotransposition of an mRNA from this gene, followed by amplification of the retroposed gene. Proteins encoded by this gene superfamily possess a chromodomain, a motif implicated in chromatin binding and gene suppression, and a catalytic domain believed to be involved in histone acetylation. Multiple proteins are encoded by transcript variants of this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cell differentiation, negative regulation of DNA-templated transcription, negative regulation of peptidyl-lysine crotonylation, random inactivation of X chromosome, spermatid development, spermatogenesis; MF: chromatin binding, crotonyl-CoA hydratase activity, identical protein binding, lyase activity, protein binding, protein-macromolecule adaptor activity, transcription corepressor activity; CC: chromosome, cytoplasm, nuclear speck, nucleus
Pathways:
UniProt: Q9Y232
Entrez ID: 9425
|
Does Knockout of GABRD in Endometrial Cancer Cell Line causally result in cell proliferation?
| 0
| 758
|
Knockout
|
GABRD
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: GABRD (gamma-aminobutyric acid type A receptor subunit delta)
Type: protein-coding
Summary: Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. The GABA-A receptor is generally pentameric and there are five types of subunits: alpha, beta, gamma, delta, and rho. This gene encodes the delta subunit. Mutations in this gene have been associated with susceptibility to generalized epilepsy with febrile seizures, type 5. Alternatively spliced transcript variants have been described for this gene, but their biological validity has not been determined. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cell-cell signaling, chemical synaptic transmission, chloride transmembrane transport, chloride transport, gamma-aminobutyric acid signaling pathway, monoatomic ion transmembrane transport, monoatomic ion transport, regulation of postsynaptic membrane potential, signal transduction, synaptic transmission, GABAergic; MF: GABA-A receptor activity, chloride channel activity, extracellular ligand-gated monoatomic ion channel activity, monoatomic ion channel activity, protein binding, transmembrane signaling receptor activity, transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential; CC: GABA-A receptor complex, GABA-ergic synapse, axon, chloride channel complex, dendrite, glutamatergic synapse, membrane, neuronal cell body, plasma membrane, postsynaptic membrane
Pathways: Fragile X Syndrome, GABA receptor Signaling, GABAergic synapse - Homo sapiens (human), Morphine addiction - Homo sapiens (human), Neuroactive ligand-receptor interaction - Homo sapiens (human), Nicotine addiction - Homo sapiens (human), Prader-Willi and Angelman Syndrome, Retrograde endocannabinoid signaling - Homo sapiens (human), Rett syndrome causing genes, mBDNF and proBDNF regulation of GABA neurotransmission
UniProt: O14764
Entrez ID: 2563
|
Does Knockout of LYG1 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 334
|
Knockout
|
LYG1
|
cell proliferation
|
Esophageal Squamous Cell Carcinoma Cell Line
|
Gene: LYG1 (lysozyme g1)
Type: protein-coding
Summary: Predicted to enable lysozyme activity. Predicted to be involved in defense response to Gram-positive bacterium. Predicted to be active in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: defense response to Gram-positive bacterium, peptidoglycan catabolic process; MF: hydrolase activity, hydrolase activity, acting on glycosyl bonds, lysozyme activity, protein binding; CC: extracellular region
Pathways:
UniProt: Q8N1E2
Entrez ID: 129530
|
Does Knockout of PPP1R36 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 427
|
Knockout
|
PPP1R36
|
cell proliferation
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: PPP1R36 (protein phosphatase 1 regulatory subunit 36)
Type: protein-coding
Summary: Predicted to enable phosphatase binding activity and protein phosphatase inhibitor activity. Predicted to be involved in negative regulation of phosphatase activity. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: phosphatase binding, protein phosphatase inhibitor activity
Pathways:
UniProt: Q96LQ0
Entrez ID: 145376
|
Does Knockout of POLR1E in Cancer Cell Line causally result in cell proliferation?
| 1
| 193
|
Knockout
|
POLR1E
|
cell proliferation
|
Cancer Cell Line
|
Gene: POLR1E (RNA polymerase I subunit E)
Type: protein-coding
Summary: Predicted to enable DNA binding activity; DNA-directed 5'-3' RNA polymerase activity; and RNA polymerase I general transcription initiation factor binding activity. Involved in nucleolar large rRNA transcription by RNA polymerase I. Located in fibrillar center and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: DNA-templated transcription, RNA polymerase I preinitiation complex assembly, nucleolar large rRNA transcription by RNA polymerase I, transcription elongation by RNA polymerase I, transcription initiation at RNA polymerase I promoter; MF: DNA binding, RNA polymerase I general transcription initiation factor binding, protein binding; CC: DNA-directed RNA polymerase complex, RNA polymerase I complex, fibrillar center, nucleolus, nucleoplasm, nucleus
Pathways: B-WICH complex positively regulates rRNA expression, Epigenetic regulation of gene expression, Eukaryotic Transcription Initiation, Gene expression (Transcription), Negative epigenetic regulation of rRNA expression, NoRC negatively regulates rRNA expression, Positive epigenetic regulation of rRNA expression, Pyrimidine metabolism, RNA Polymerase I Promoter Clearance, RNA Polymerase I Promoter Escape, RNA Polymerase I Transcription, RNA Polymerase I Transcription Initiation, RNA Polymerase I Transcription Termination, RNA polymerase - Homo sapiens (human), TNFalpha
UniProt: Q9GZS1
Entrez ID: 64425
|
Does Knockout of ACTN1 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 839
|
Knockout
|
ACTN1
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: ACTN1 (actinin alpha 1)
Type: protein-coding
Summary: Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: actin cytoskeleton organization, actin filament bundle assembly, actin filament network formation, actin filament organization, anatomical structure formation involved in morphogenesis, focal adhesion assembly, muscle cell development, platelet activation, platelet aggregation, platelet formation, platelet morphogenesis, positive regulation of DNA-templated transcription, postsynapse organization, regulation of apoptotic process; MF: actin binding, actin filament binding, calcium ion binding, cytoskeletal protein binding, double-stranded RNA binding, identical protein binding, integrin binding, metal ion binding, protein binding, protein homodimerization activity, structural constituent of postsynapse, transcription coactivator activity, transmembrane transporter binding, vinculin binding; CC: Z disc, actin cytoskeleton, actin filament, anchoring junction, brush border, cell junction, cell projection, cell-cell junction, cortical actin cytoskeleton, cytoplasm, cytoskeleton, cytosol, extracellular exosome, extracellular region, extracellular space, fascia adherens, focal adhesion, glutamatergic synapse, membrane, plasma membrane, platelet alpha granule lumen, pseudopodium, ruffle, sarcomere, stress fiber, synapse
Pathways: Adherens junction - Homo sapiens (human), Amoebiasis - Homo sapiens (human), Arrhythmogenic Right Ventricular Cardiomyopathy, Cell junction organization, Cell-Cell communication, Cell-extracellular matrix interactions, EGFR1, Ebola Virus Pathway on Host, Extracellular matrix organization, Focal Adhesion, Focal adhesion - Homo sapiens (human), Hemostasis, Integrin-linked kinase signaling, Leukocyte transendothelial migration - Homo sapiens (human), MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement, Nephrin family interactions, Non-integrin membrane-ECM interactions, Platelet activation, signaling and aggregation, Platelet degranulation , RHO GTPase cycle, RHOBTB GTPase Cycle, RHOBTB2 GTPase cycle, RHOD GTPase cycle, RHOF GTPase cycle, Regulation of Actin Cytoskeleton, Regulation of actin cytoskeleton - Homo sapiens (human), Regulation of cytoskeletal remodeling and cell spreading by IPP complex components, Response to elevated platelet cytosolic Ca2+, Shigellosis - Homo sapiens (human), Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling events mediated by focal adhesion kinase, Stabilization and expansion of the E-cadherin adherens junction, Syndecan interactions, Syndecan-4-mediated signaling events, Systemic lupus erythematosus - Homo sapiens (human), Tight junction - Homo sapiens (human), Viral carcinogenesis - Homo sapiens (human), erk and pi-3 kinase are necessary for collagen binding in corneal epithelia, integrin signaling pathway, ucalpain and friends in cell spread
UniProt: P12814
Entrez ID: 87
|
Does Knockout of PPRC1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 427
|
Knockout
|
PPRC1
|
cell proliferation
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: PPRC1 (PPARG related coactivator 1)
Type: protein-coding
Summary: The protein encoded by this gene is similar to PPAR-gamma coactivator 1 (PPARGC1/PGC-1), a protein that can activate mitochondrial biogenesis in part through a direct interaction with nuclear respiratory factor 1 (NRF1). This protein has been shown to interact with NRF1. It is thought to be a functional relative of PPAR-gamma coactivator 1 that activates mitochondrial biogenesis through NRF1 in response to proliferative signals. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013].
Gene Ontology: BP: energy homeostasis, positive regulation of transcription by RNA polymerase II; MF: RNA binding, nucleic acid binding, transcription coactivator activity, transcription coregulator activity; CC: nucleoplasm, nucleus
Pathways: Energy Metabolism, Mitochondrial Gene Expression, Mitochondrial biogenesis, Organelle biogenesis and maintenance, Transcriptional activation of mitochondrial biogenesis
UniProt: Q5VV67
Entrez ID: 23082
|
Does Knockout of TNFRSF10C in Cervical Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,352
|
Knockout
|
TNFRSF10C
|
response to chemicals
|
Cervical Adenocarcinoma Cell Line
|
Gene: TNFRSF10C (TNF receptor superfamily member 10c)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: TRAIL-activated apoptotic signaling pathway, apoptotic process, positive regulation of apoptotic process; MF: TRAIL binding, protein binding, transmembrane signaling receptor activity; CC: cell surface, membrane, plasma membrane, side of membrane
Pathways: Apoptosis Modulation and Signaling, Cytokine-cytokine receptor interaction - Homo sapiens (human), Direct p53 effectors, Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription, TP53 Regulates Transcription of Cell Death Genes, TP53 Regulates Transcription of Death Receptors and Ligands, TRAIL signaling pathway, Transcriptional Regulation by TP53, VEGFA-VEGFR2 Signaling Pathway, Viral protein interaction with cytokine and cytokine receptor - Homo sapiens (human)
UniProt: O14798
Entrez ID: 8794
|
Does Knockout of TPT1 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 1
| 2,119
|
Knockout
|
TPT1
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: TPT1 (tumor protein, translationally-controlled 1)
Type: protein-coding
Summary: This gene encodes a protein that is a regulator of cellular growth and proliferation. Its mRNA is highly structured and contains an oligopyrimidine tract (5'-TOP) in its 5' untranslated region that functions to repress its translation under quiescent conditions. The encoded protein is involved in a variety of cellular pathways, including apoptosis, protein synthesis and cell division. It binds to and stabilizes microtubules, and removal of this protein through phosphorylation is required for progression through mitotic and meiotic cell divisions. This gene is known to play a role in carcinogenesis, and is upregulated in some cancer cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017].
Gene Ontology: BP: calcium ion transport, intracellular calcium ion homeostasis, negative regulation of apoptotic process, negative regulation of ectoderm development, negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage, regulation of apoptotic process, response to virus, stem cell population maintenance; MF: DNA-binding transcription factor binding, RNA binding, calcium ion binding, protein binding; CC: cytoplasm, cytoplasmic microtubule, cytosol, extracellular exosome, extracellular space, multivesicular body, nucleoplasm, nucleus, spindle pole
Pathways: PLK1 signaling events
UniProt: P13693
Entrez ID: 7178
|
Does Knockout of MBTPS1 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 305
|
Knockout
|
MBTPS1
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: MBTPS1 (membrane bound transcription factor peptidase, site 1)
Type: protein-coding
Summary: This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the cis/medial-Golgi where a second autocatalytic event takes place and the catalytic activity is acquired. It encodes a type 1 membrane bound protease which is ubiquitously expressed and regulates cholesterol or lipid homeostasis via cleavage of substrates at non-basic residues. Mutations in this gene may be associated with lysosomal dysfunction. [provided by RefSeq, Feb 2014].
Gene Ontology: BP: ATF6-mediated unfolded protein response, NLS-bearing protein import into nucleus, cholesterol metabolic process, endoplasmic reticulum unfolded protein response, lipid metabolic process, lysosome organization, membrane protein intracellular domain proteolysis, mitotic G2 DNA damage checkpoint signaling, positive regulation of cholesterol biosynthetic process, protein import into nucleus, protein maturation, protein processing, proteolysis, regulation of cholesterol biosynthetic process, regulation of vesicle-mediated transport, response to endoplasmic reticulum stress, steroid metabolic process; MF: endopeptidase activity, hydrolase activity, peptidase activity, protein binding, serine-type endopeptidase activity, serine-type peptidase activity; CC: Golgi apparatus, Golgi membrane, Golgi stack, endoplasmic reticulum, endoplasmic reticulum lumen, endoplasmic reticulum membrane, membrane
Pathways: ATF6 (ATF6-alpha) activates chaperones, ATF6B (ATF6-beta) activates chaperones, Assembly of active LPL and LIPC lipase complexes, CREB3 factors activate genes, Cellular responses to stimuli, Cellular responses to stress, IL-18 signaling pathway, Metabolism, Metabolism of lipids, Metabolism of proteins, Metabolism of steroids, Plasma lipoprotein assembly, remodeling, and clearance, Plasma lipoprotein remodeling, Post-translational protein modification, Post-translational protein phosphorylation, Protein processing in endoplasmic reticulum - Homo sapiens (human), Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Regulation of cholesterol biosynthesis by SREBP (SREBF), Sterol regulatory element-binding proteins (SREBP) signaling, Transport of small molecules, Type I collagen synthesis in the context of Osteogenesis imperfecta, Unfolded Protein Response (UPR), Unfolded protein response, srebp control of lipid synthesis
UniProt: Q14703
Entrez ID: 8720
|
Does Knockout of NEU3 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,032
|
Knockout
|
NEU3
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: NEU3 (neuraminidase 3)
Type: protein-coding
Summary: This gene product belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. It is localized in the plasma membrane, and its activity is specific for gangliosides. It may play a role in modulating the ganglioside content of the lipid bilayer. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: carbohydrate metabolic process, ganglioside catabolic process, glycosphingolipid catabolic process, lipid catabolic process, lipid metabolic process, negative regulation of clathrin-dependent endocytosis, oligosaccharide catabolic process, positive regulation of epidermal growth factor receptor signaling pathway; MF: alpha-sialidase activity, exo-alpha-sialidase activity, hydrolase activity, hydrolase activity, acting on glycosyl bonds, protein binding; CC: caveola, cytoplasm, early endosome membrane, endosome, lysosomal membrane, lysosome, membrane, plasma membrane, recycling endosome membrane
Pathways: Asparagine N-linked glycosylation, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, Fabry disease, Gaucher Disease, Globoid Cell Leukodystrophy, Glycosphingolipid catabolism, Glycosphingolipid metabolism, Krabbe disease, Metabolism, Metabolism of lipids, Metabolism of proteins, Metachromatic Leukodystrophy (MLD), Other glycan degradation - Homo sapiens (human), Post-translational protein modification, Sialic acid metabolism, Sphingolipid Metabolism, Sphingolipid metabolism, Sphingolipid metabolism - Homo sapiens (human), Synthesis of substrates in N-glycan biosythesis
UniProt: Q9UQ49
Entrez ID: 10825
|
Does Knockout of RELT in Lymphoma or Leukaemia Cell Line causally result in protein/peptide accumulation?
| 0
| 1,218
|
Knockout
|
RELT
|
protein/peptide accumulation
|
Lymphoma or Leukaemia Cell Line
|
Gene: RELT (RELT TNF receptor)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is especially abundant in hematologic tissues. It has been shown to activate the NF-kappaB pathway and selectively bind TNF receptor-associated factor 1 (TRAF1). This receptor is capable of stimulating T-cell proliferation in the presence of CD3 signaling, which suggests its regulatory role in immune response. Two alternatively spliced transcript variants of this gene encoding the same protein have been reported. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: amelogenesis, apoptotic process; CC: cytoplasm, cytosol, membrane, nucleolus, nucleoplasm, perinuclear region of cytoplasm, plasma membrane
Pathways: Cytokine-cytokine receptor interaction - Homo sapiens (human)
UniProt: Q969Z4
Entrez ID: 84957
|
Does Knockout of UBXN7 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,459
|
Knockout
|
UBXN7
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: UBXN7 (UBX domain protein 7)
Type: protein-coding
Summary: Enables ubiquitin binding activity and ubiquitin protein ligase binding activity. Located in nuclear body. Part of VCP-NPL4-UFD1 AAA ATPase complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: RNA polymerase II-specific DNA-binding transcription factor binding, protein binding, ubiquitin binding, ubiquitin protein ligase binding; CC: VCP-NPL4-UFD1 AAA ATPase complex, cytosol, nucleoplasm, nucleus
Pathways: 3q29 copy number variation syndrome, Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, KEAP1-NFE2L2 pathway, Metabolism of proteins, Neddylation, Post-translational protein modification
UniProt: O94888
Entrez ID: 26043
|
Does Knockout of UBR5 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,329
|
Knockout
|
UBR5
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: UBR5 (ubiquitin protein ligase E3 component n-recognin 5)
Type: protein-coding
Summary: This gene encodes a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family. The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific proteins for ubiquitin-mediated proteolysis. This gene is localized to chromosome 8q22 which is disrupted in a variety of cancers. This gene potentially has a role in regulation of cell proliferation or differentiation. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA damage response, DNA repair, DNA repair-dependent chromatin remodeling, cytoplasm protein quality control, cytoplasm protein quality control by the ubiquitin-proteasome system, estrogen receptor signaling pathway, heterochromatin boundary formation, negative regulation of smoothened signaling pathway, nuclear protein quality control by the ubiquitin-proteasome system, positive regulation of canonical Wnt signaling pathway, positive regulation of gene expression, positive regulation of protein import into nucleus, progesterone receptor signaling pathway, proteasomal protein catabolic process, proteasome-mediated ubiquitin-dependent protein catabolic process, protein K11-linked ubiquitination, protein K29-linked ubiquitination, protein K48-linked ubiquitination, protein branched polyubiquitination, protein polyubiquitination, protein ubiquitination, response to oxidative stress, retinoic acid receptor signaling pathway, vitamin D receptor signaling pathway; MF: RNA binding, metal ion binding, protein binding, transferase activity, ubiquitin binding, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, ubiquitin-ubiquitin ligase activity, zinc ion binding; CC: chromatin, cytoplasm, cytosol, membrane, nucleoplasm, nucleus, perinuclear region of cytoplasm, protein-containing complex
Pathways: Mesodermal commitment pathway, Ubiquitin mediated proteolysis - Homo sapiens (human)
UniProt: O95071
Entrez ID: 51366
|
Does Knockout of SMAD6 in Cervical Adenocarcinoma Cell Line causally result in protein/peptide accumulation?
| 0
| 2,404
|
Knockout
|
SMAD6
|
protein/peptide accumulation
|
Cervical Adenocarcinoma Cell Line
|
Gene: SMAD6 (SMAD family member 6)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the SMAD family of proteins, which are related to Drosophila 'mothers against decapentaplegic' (Mad) and C. elegans Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions in the negative regulation of BMP and TGF-beta/activin-signalling. Multiple transcript variants have been found for this gene.[provided by RefSeq, Sep 2014].
Gene Ontology: BP: BMP signaling pathway, SMAD protein signal transduction, anatomical structure morphogenesis, aorta development, aortic valve morphogenesis, cell differentiation, cell-substrate adhesion, cellular response to growth factor stimulus, coronary vasculature development, fat cell differentiation, heart valve development, immune response, mitral valve morphogenesis, negative regulation of BMP signaling pathway, negative regulation of SMAD protein signal transduction, negative regulation of activin receptor signaling pathway, negative regulation of apoptotic process, negative regulation of cell differentiation, negative regulation of cell population proliferation, negative regulation of ossification, negative regulation of osteoblast differentiation, negative regulation of transforming growth factor beta receptor signaling pathway, outflow tract septum morphogenesis, positive regulation of miRNA transcription, pulmonary valve morphogenesis, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, response to estrogen, response to laminar fluid shear stress, response to lipopolysaccharide, transforming growth factor beta receptor superfamily signaling pathway, ureteric bud development, ventricular septum development, zygotic specification of dorsal/ventral axis; MF: I-SMAD binding, R-SMAD binding, activin receptor binding, chromatin binding, co-SMAD binding, identical protein binding, metal ion binding, protein binding, protein sequestering activity, transcription cis-regulatory region binding, transcription regulator inhibitor activity, type I activin receptor binding, type I transforming growth factor beta receptor binding, ubiquitin protein ligase binding; CC: Golgi apparatus, chromatin, ciliary basal body, cilium, cytoplasm, cytosol, heteromeric SMAD protein complex, nuclear body, nucleoplasm, nucleus, protein-containing complex, transcription regulator complex
Pathways: BMP Signalling Pathway, BMP receptor signaling, Bone morphogenic protein (BMP) signaling and regulation, ESC Pluripotency Pathways, Mesodermal commitment pathway, Regulation of toll-like receptor signaling pathway, TGF-beta Receptor Signaling, TGF-beta receptor signaling in skeletal dysplasias, TGF-beta signaling pathway - Homo sapiens (human), TGF_beta_Receptor, alk in cardiac myocytes, ctcf: first multivalent nuclear factor
UniProt: O43541
Entrez ID: 4091
|
Does Knockout of ADAM22 in Astrocytoma Cell Line causally result in cell proliferation?
| 0
| 904
|
Knockout
|
ADAM22
|
cell proliferation
|
Astrocytoma Cell Line
|
Gene: ADAM22 (ADAM metallopeptidase domain 22)
Type: protein-coding
Summary: This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Unlike other members of the ADAM protein family, the protein encoded by this gene lacks metalloprotease activity since it has no zinc-binding motif. This gene is highly expressed in the brain and may function as an integrin ligand in the brain. In mice, it has been shown to be essential for correct myelination in the peripheral nervous system. Alternative splicing results in several transcript variants.[provided by RefSeq, Dec 2010].
Gene Ontology: BP: cell adhesion, central nervous system development, negative regulation of cell adhesion, positive regulation of synaptic transmission, proteolysis; MF: integrin binding, metalloendopeptidase activity, metallopeptidase activity, protein binding, signaling receptor activity; CC: axon, cell projection, membrane, plasma membrane, postsynaptic density membrane
Pathways:
UniProt: Q9P0K1
Entrez ID: 53616
|
Does Knockout of ZIC1 in Hepatoma Cell Line causally result in response to virus?
| 0
| 2,447
|
Knockout
|
ZIC1
|
response to virus
|
Hepatoma Cell Line
|
Gene: ZIC1 (Zic family zinc finger 1)
Type: protein-coding
Summary: This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development. Aberrant expression of this gene is seen in medulloblastoma, a childhood brain tumor. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 4, a related family member on chromosome 3. This gene encodes a transcription factor that can bind and transactivate the apolipoprotein E gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: adult walking behavior, brain development, cell differentiation, central nervous system development, forebrain development, gene expression, hippocampus development, inner ear morphogenesis, maintenance of cell number, nervous system development, olfactory bulb development, pattern specification process, positive regulation of DNA-templated transcription, positive regulation of protein import into nucleus, positive regulation of transcription by RNA polymerase II, regulation of smoothened signaling pathway, regulation of transcription by RNA polymerase II, spinal cord development; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, metal ion binding, protein binding, sequence-specific double-stranded DNA binding, zinc ion binding; CC: cytoplasm, nucleoplasm, nucleus
Pathways: Developmental Biology, Differentiation of white and brown adipocyte, Gastrulation, MITF-M-regulated melanocyte development, Neural Crest Differentiation, Specification of the neural plate border, Transcriptional and post-translational regulation of MITF-M expression and activity
UniProt: Q15915
Entrez ID: 7545
|
Does Knockout of ACYP1 in Breast Cancer Cell Line causally result in cell proliferation?
| 0
| 235
|
Knockout
|
ACYP1
|
cell proliferation
|
Breast Cancer Cell Line
|
Gene: ACYP1 (acylphosphatase 1)
Type: protein-coding
Summary: This gene is a member of the acylphosphatase family. The encoded protein is a small cytosolic enzyme that catalyzes the hydrolysis of the carboxyl-phosphate bond of acylphosphates. Two isoenzymes have been isolated and described based on their tissue localization: erythrocyte (common) type acylphosphatase encoded by this gene, and muscle type acylphosphatase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014].
Gene Ontology: MF: acylphosphatase activity, hydrolase activity
Pathways: Leigh Syndrome, Primary hyperoxaluria II, PH2, Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency), Pyruvate Dehydrogenase Complex Deficiency, Pyruvate Metabolism, Pyruvate kinase deficiency, Pyruvate metabolism - Homo sapiens (human)
UniProt: P07311
Entrez ID: 97
|
Does Knockout of RANBP1 in acute lymphoblastic leukemia cell line causally result in cell proliferation?
| 1
| 1,957
|
Knockout
|
RANBP1
|
cell proliferation
|
acute lymphoblastic leukemia cell line
|
Gene: RANBP1 (RAN binding protein 1)
Type: protein-coding
Summary: This gene encodes a protein that forms a complex with Ras-related nuclear protein (Ran) and metabolizes guanoside triphosphate (GTP). This complex participates in the regulation of the cell cycle by controlling transport of proteins and nucleic acids into the nucleus. There are multiple pseudogenes for this gene on chromosomes 9, 12, 17, and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].
Gene Ontology: BP: nucleocytoplasmic transport, positive regulation of mitotic centrosome separation, signal transduction; MF: GDP-dissociation inhibitor activity, GTPase activator activity, cadherin binding, protein binding, small GTPase binding; CC: centrosome, cytoplasm, cytosol, nuclear envelope, nuclear pore, nucleus
Pathways: 22q11.2 copy number variation syndrome, Disease, E2F transcription factor network, HIV Infection, HIV Life Cycle, Host Interactions of HIV factors, Human T-cell leukemia virus 1 infection - Homo sapiens (human), Infectious disease, Interactions of Rev with host cellular proteins, Late Phase of HIV Life Cycle, Rev-mediated nuclear export of HIV RNA, Viral Infection Pathways, Viral carcinogenesis - Homo sapiens (human), cycling of ran in nucleocytoplasmic transport, mechanism of protein import into the nucleus, role of ran in mitotic spindle regulation
UniProt: P43487
Entrez ID: 5902
|
Does Knockout of ABLIM2 in Lung Cancer Cell Line causally result in response to virus?
| 0
| 1,433
|
Knockout
|
ABLIM2
|
response to virus
|
Lung Cancer Cell Line
|
Gene: ABLIM2 (actin binding LIM protein family member 2)
Type: protein-coding
Summary: Predicted to enable actin filament binding activity. Predicted to be involved in lamellipodium assembly. Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II. Located in actin cytoskeleton. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cytoskeleton organization, lamellipodium assembly; MF: actin binding, actin filament binding, metal ion binding, protein binding; CC: actin cytoskeleton, cytoplasm
Pathways: Axon guidance - Homo sapiens (human)
UniProt: Q6H8Q1
Entrez ID: 84448
|
Does Knockout of TAAR6 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 865
|
Knockout
|
TAAR6
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: TAAR6 (trace amine associated receptor 6)
Type: protein-coding
Summary: This gene encodes a seven-transmembrane G-protein-coupled receptor that likely functions as a receptor for endogenous trace amines. Mutations in this gene may be associated with schizophrenia.[provided by RefSeq, Feb 2010].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, adenylate cyclase-activating G protein-coupled receptor signaling pathway, sensory perception of smell, signal transduction; MF: G protein-coupled receptor activity, trace-amine receptor activity; CC: membrane, plasma membrane
Pathways: Amine ligand-binding receptors, Class A/1 (Rhodopsin-like receptors), G alpha (s) signalling events, GPCR downstream signalling, GPCR ligand binding, Neuroactive ligand-receptor interaction - Homo sapiens (human), Signal Transduction, Signaling by GPCR
UniProt: Q96RI8
Entrez ID: 319100
|
Does Knockout of WNK1 in Glioma Cell Line causally result in protein/peptide accumulation?
| 0
| 589
|
Knockout
|
WNK1
|
protein/peptide accumulation
|
Glioma Cell Line
|
Gene: WNK1 (WNK lysine deficient protein kinase 1)
Type: protein-coding
Summary: This gene encodes a member of the WNK subfamily of serine/threonine protein kinases. The encoded protein may be a key regulator of blood pressure by controlling the transport of sodium and chloride ions. Mutations in this gene have been associated with pseudohypoaldosteronism type II and hereditary sensory neuropathy type II. Alternatively spliced transcript variants encoding different isoforms have been described but the full-length nature of all of them has yet to be determined.[provided by RefSeq, May 2010].
Gene Ontology: BP: DNA damage response, T cell receptor signaling pathway, cell volume homeostasis, cellular hyperosmotic response, cellular response to chemokine, chemokine (C-C motif) ligand 21 signaling pathway, heart development, homeostatic process, intracellular chloride ion homeostasis, intracellular signal transduction, lymphocyte migration into lymph node, membraneless organelle assembly, monoatomic cation homeostasis, monoatomic ion transport, negative regulation of autophagy, negative regulation of cell-cell adhesion mediated by integrin, negative regulation of heterotypic cell-cell adhesion, negative regulation of leukocyte cell-cell adhesion, negative regulation of pancreatic juice secretion, negative regulation of protein localization to plasma membrane, negative regulation of protein ubiquitination, negative regulation of small GTPase mediated signal transduction, negative regulation of sodium ion transport, neuron development, positive regulation of T cell chemotaxis, positive regulation of angiogenesis, positive regulation of canonical Wnt signaling pathway, positive regulation of mitotic cytokinesis, positive regulation of systemic arterial blood pressure, positive regulation of termination of RNA polymerase II transcription, potassium ion homeostasis, potassium ion transmembrane transport, protein insertion into ER membrane by stop-transfer membrane-anchor sequence, protein phosphorylation, regulation of blood pressure, regulation of mRNA export from nucleus, regulation of monoatomic cation transmembrane transport, regulation of sodium ion transmembrane transport, regulation of sodium ion transport, signal transduction, sodium ion transmembrane transport; MF: ATP binding, kinase activity, molecular condensate scaffold activity, nucleotide binding, phosphatase binding, protein binding, protein kinase activator activity, protein kinase activity, protein kinase binding, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cytoplasm, cytoskeleton, cytosol, intracellular membraneless organelle, membrane, mitotic spindle, nucleus, protein-containing complex, spindle
Pathways: Ciliary landscape, Ion channel transport, Stimuli-sensing channels, Transport of small molecules
UniProt: Q9H4A3
Entrez ID: 65125
|
Does Knockout of TSHZ2 in Renal Cancer Cell Line causally result in cell proliferation?
| 0
| 319
|
Knockout
|
TSHZ2
|
cell proliferation
|
Renal Cancer Cell Line
|
Gene: TSHZ2 (teashirt zinc finger homeobox 2)
Type: protein-coding
Summary: This gene is a member of the teashirt C2H2-type zinc-finger protein family of transcription factors. This gene encodes a protein with five C2H2-type zinc fingers, a homeobox DNA-binding domain and a coiled-coil domain. This nuclear protein is predicted to act as a transcriptional repressor. This gene is thought to play a role in the development and progression of breast and other types of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016].
Gene Ontology: BP: regulation of gene expression, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, metal ion binding, protein binding, zinc ion binding; CC: chromatin, nucleus
Pathways:
UniProt: Q9NRE2
Entrez ID: 128553
|
Does Knockout of KRTAP1-5 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 815
|
Knockout
|
KRTAP1-5
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: KRTAP1-5 (keratin associated protein 1-5)
Type: protein-coding
Summary: This protein is a member of the keratin-associated protein (KAP) family. The KAP proteins form a matrix of keratin intermediate filaments which contribute to the structure of hair fibers. KAP family members appear to have unique, family-specific amino- and carboxyl-terminal regions and are subdivided into three multi-gene families according to amino acid composition: the high sulfur, the ultrahigh sulfur, and the high tyrosine/glycine KAPs. This protein is a member of the high sulfur KAP family and the gene is localized to a cluster of KAPs at 17q12-q21. [provided by RefSeq, Jul 2008].
Gene Ontology: CC: cytosol, intermediate filament, keratin filament
Pathways: Developmental Biology, Keratinization
UniProt: Q9BYS1
Entrez ID: 83895
|
Does Knockout of LIF in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 387
|
Knockout
|
LIF
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: LIF (LIF interleukin 6 family cytokine)
Type: protein-coding
Summary: The protein encoded by this gene is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012].
Gene Ontology: BP: blood vessel remodeling, cell differentiation, cell morphogenesis, cell population proliferation, cell surface receptor signaling pathway via STAT, decidualization, embryo implantation, fibroblast proliferation, gene expression, immune response, leukemia inhibitory factor signaling pathway, lung alveolus development, lung development, lung lobe morphogenesis, lung vasculature development, macrophage differentiation, maternal process involved in female pregnancy, meiotic nuclear division, muscle organ morphogenesis, negative regulation of ERK1 and ERK2 cascade, negative regulation of cell population proliferation, negative regulation of hormone secretion, negative regulation of meiotic nuclear division, neuron development, positive regulation of MAPK cascade, positive regulation of astrocyte differentiation, positive regulation of cell adhesion mediated by integrin, positive regulation of cell population proliferation, positive regulation of fibroblast proliferation, positive regulation of gene expression, positive regulation of macrophage differentiation, positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis, positive regulation of multicellular organismal process, positive regulation of peptidyl-serine phosphorylation, positive regulation of peptidyl-tyrosine phosphorylation, positive regulation of receptor signaling pathway via STAT, positive regulation of transcription by RNA polymerase II, regulation of cell communication, regulation of cell differentiation, regulation of metanephric nephron tubule epithelial cell differentiation, regulation of multicellular organismal development, regulation of signaling, response to hypoxia, somatic stem cell population maintenance, stem cell differentiation, trophoblast giant cell differentiation; MF: cytokine activity, growth factor activity, leukemia inhibitory factor receptor binding, protein binding, signaling receptor binding; CC: cytosol, extracellular region, extracellular space
Pathways: Adipogenesis, Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Homo sapiens (human), Direct p53 effectors, ESC Pluripotency Pathways, IL-6-type cytokine receptor ligand interactions, Immune System, Interleukin-10 signaling, Interleukin-4 and Interleukin-13 signaling, Interleukin-6 family signaling, JAK-STAT signaling pathway - Homo sapiens (human), MicroRNAs in cardiomyocyte hypertrophy, Signaling by Interleukins, Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human), TGF-beta Receptor Signaling, TGF-beta receptor signaling in skeletal dysplasias, TNF signaling pathway - Homo sapiens (human), Validated transcriptional targets of AP1 family members Fra1 and Fra2, nfat and hypertrophy of the heart , p53 transcriptional gene network
UniProt: P15018
Entrez ID: 3976
|
Does Knockout of AFAP1L2 in Non-Small Cell Lung Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 1,391
|
Knockout
|
AFAP1L2
|
response to chemicals
|
Non-Small Cell Lung Adenocarcinoma Cell Line
|
Gene: AFAP1L2 (actin filament associated protein 1 like 2)
Type: protein-coding
Summary: Enables SH2 domain binding activity; SH3 domain binding activity; and protein tyrosine kinase activator activity. Involved in several processes, including positive regulation of epidermal growth factor receptor signaling pathway; regulation of gene expression; and regulation of mitotic cell cycle. Located in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: inflammatory response, positive regulation of DNA-templated transcription, positive regulation of epidermal growth factor receptor signaling pathway, positive regulation of interleukin-8 production, regulation of interleukin-6 production, regulation of mitotic cell cycle; MF: SH2 domain binding, SH3 domain binding, protein tyrosine kinase activator activity; CC: cytoplasm, cytosol, plasma membrane
Pathways: EGFR1
UniProt: Q8N4X5
Entrez ID: 84632
|
Does Knockout of DDX55 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 758
|
Knockout
|
DDX55
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: DDX55 (DEAD-box helicase 55)
Type: protein-coding
Summary: This gene encodes a member of protein family containing a characteristic Asp-Glu-Ala-Asp (DEAD) motif. These proteins are putative RNA helicases, and may be involved in a range of nuclear processes including translational initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Multiple alternatively spliced transcript variants have been found for this gene. Pseudogenes have been identified on chromosomes 1 and 12. [provided by RefSeq, Feb 2016].
Gene Ontology: BP: maturation of LSU-rRNA, rRNA processing, ribosome biogenesis; MF: ATP binding, ATP hydrolysis activity, RNA binding, RNA helicase activity, helicase activity, hydrolase activity, large ribosomal subunit rRNA binding, nucleic acid binding, nucleotide binding, protein binding, rRNA binding; CC: cytosol, membrane, nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: Q8NHQ9
Entrez ID: 57696
|
Does Knockout of NOS1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,789
|
Knockout
|
NOS1
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: NOS1 (nitric oxide synthase 1)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the family of nitric oxide synthases, which synthesize nitric oxide from L-arginine. Nitric oxide is a reactive free radical, which acts as a biologic mediator in several processes, including neurotransmission, and antimicrobial and antitumoral activities. In the brain and peripheral nervous system, nitric oxide displays many properties of a neurotransmitter, and has been implicated in neurotoxicity associated with stroke and neurodegenerative diseases, neural regulation of smooth muscle, including peristalsis, and penile erection. This protein is ubiquitously expressed, with high level of expression in skeletal muscle. Multiple transcript variants that differ in the 5' UTR have been described for this gene but the full-length nature of these transcripts is not known. Additionally, alternatively spliced transcript variants encoding different isoforms (some testis-specific) have been found for this gene.[provided by RefSeq, Feb 2011].
Gene Ontology: BP: L-arginine catabolic process, blood circulation, calcium ion transport, cell communication, cell redox homeostasis, cellular response to growth factor stimulus, establishment of localization in cell, multicellular organismal response to stress, myoblast fusion, negative regulation of blood pressure, negative regulation of calcium ion transport, negative regulation of calcium ion transport into cytosol, negative regulation of monoatomic ion transport, negative regulation of potassium ion transport, negative regulation of serotonin uptake, nitric oxide biosynthetic process, nitric oxide mediated signal transduction, positive regulation of DNA-templated transcription, positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway, positive regulation of membrane repolarization during ventricular cardiac muscle cell action potential, positive regulation of neuron apoptotic process, positive regulation of sodium ion transmembrane transport, positive regulation of the force of heart contraction, positive regulation of transcription by RNA polymerase II, potassium ion transport, regulation of biological quality, regulation of blood circulation, regulation of calcium ion transmembrane transport via high voltage-gated calcium channel, regulation of cardiac muscle contraction, regulation of cardiac muscle contraction by calcium ion signaling, regulation of metal ion transport, regulation of neurogenesis, regulation of postsynaptic membrane potential, regulation of sodium ion transport, response to heat, response to hormone, response to hypoxia, response to lipopolysaccharide, signaling, striated muscle contraction, synaptic signaling by nitric oxide, vasodilation, xenobiotic catabolic process; MF: FMN binding, NADP binding, arginine binding, cadmium ion binding, calcium channel regulator activity, calcium-dependent protein binding, calmodulin binding, flavin adenine dinucleotide binding, heme binding, metal ion binding, nitric-oxide synthase activity, oxidoreductase activity, peptidyl-cysteine S-nitrosylase activity, protein binding, scaffold protein binding, sodium channel regulator activity, tetrahydrobiopterin binding, transmembrane transporter binding; CC: T-tubule, Z disc, calyx of Held, caveola, cell periphery, cell projection, cytoplasm, cytoskeleton, cytosol, dendritic spine, endomembrane system, membrane, membrane raft, mitochondrion, nucleoplasm, nucleus, perinuclear region of cytoplasm, photoreceptor inner segment, plasma membrane, postsynaptic density, protein-containing complex, sarcolemma, sarcoplasmic reticulum, sarcoplasmic reticulum membrane, synapse
Pathways: Alzheimer disease - Homo sapiens (human), Alzheimer,s disease, Amyotrophic lateral sclerosis (ALS), Amyotrophic lateral sclerosis - Homo sapiens (human), Apelin signaling pathway - Homo sapiens (human), Arginine and Proline Metabolism, Arginine and proline metabolism - Homo sapiens (human), Arginine biosynthesis - Homo sapiens (human), Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency), Association Between Physico-Chemical Features and Toxicity Associated Pathways, CAMKK2 Pathway, Calcium signaling pathway - Homo sapiens (human), Cardiac conduction, Circadian entrainment - Homo sapiens (human), Creatine deficiency, guanidinoacetate methyltransferase deficiency, Effects of nitric oxide, Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency), Hemostasis, Hyperornithinemia with gyrate atrophy (HOGA), Hyperornithinemia-hyperammonemia-homocitrullinuria [HHH-syndrome], Hyperprolinemia Type I, Hyperprolinemia Type II, Immune System, Innate Immune System, Ion homeostasis, L-arginine:glycine amidinotransferase deficiency, Long-term depression - Homo sapiens (human), Male infertility, Monoamine Transport, Muscle contraction, Myometrial relaxation and contraction pathways, NO metabolism in cystic fibrosis, NO-cGMP-PKG mediated Neuroprotection, Nitric oxide stimulates guanylate cyclase, Ornithine Aminotransferase Deficiency (OAT Deficiency), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Phagosome - Homo sapiens (human), Phosphodiesterases in neuronal function, Platelet homeostasis, Prolidase Deficiency (PD), Prolinemia Type II, RAC1-PAK1-p38-MMP2 Pathway, RAS and bradykinin pathways in COVID-19, ROS and RNS production in phagocytes, Relaxin signaling pathway - Homo sapiens (human), Salivary secretion - Homo sapiens (human), Serotonin Transporter Activity, Spinal Cord Injury, citrulline-nitric oxide cycle, nitric oxide signaling pathway, sumoylation as a mechanism to modulate ctbp-dependent gene responses
UniProt: P29475
Entrez ID: 4842
|
Does Knockout of NCSTN in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,329
|
Knockout
|
NCSTN
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: NCSTN (nicastrin)
Type: protein-coding
Summary: This gene encodes a type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Mutations in this gene are associated with familial acne inversa. A pseudogene of this gene is present on chromosome 21. Alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Feb 2014].
Gene Ontology: BP: G protein-coupled dopamine receptor signaling pathway, Notch receptor processing, Notch signaling pathway, T cell proliferation, adult behavior, amyloid precursor protein biosynthetic process, amyloid precursor protein catabolic process, amyloid precursor protein metabolic process, amyloid-beta formation, amyloid-beta metabolic process, cellular response to calcium ion, central nervous system myelination, cerebellum development, epithelial cell proliferation, glutamate receptor signaling pathway, learning or memory, membrane protein ectodomain proteolysis, membrane protein intracellular domain proteolysis, myeloid cell homeostasis, neuron apoptotic process, positive regulation of amyloid precursor protein biosynthetic process, protein processing, proteolysis, regulation of long-term synaptic potentiation, short-term synaptic potentiation; MF: ATPase binding, aspartic endopeptidase activity, intramembrane cleaving, endopeptidase activator activity, endopeptidase activity, growth factor receptor binding, peptidase activity, protein binding, protein-macromolecule adaptor activity; CC: Golgi apparatus, Golgi membrane, azurophil granule membrane, cytoplasmic vesicle, cytoplasmic vesicle membrane, early endosome, endomembrane system, endoplasmic reticulum, endoplasmic reticulum membrane, endosome membrane, extracellular exosome, focal adhesion, gamma-secretase complex, lysosomal membrane, lysosome, melanosome, membrane, plasma membrane, presynaptic membrane, protein-containing complex, sarcolemma, secretory vesicle, synaptic membrane, synaptic vesicle
Pathways: Activated NOTCH1 Transmits Signal to the Nucleus, Alzheimer disease - Homo sapiens (human), Alzheimer,s disease, Amyloid fiber formation, Axon guidance, Cell death signalling via NRAGE, NRIF and NADE, Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants, Constitutive Signaling by NOTCH1 PEST Domain Mutants, Death Receptor Signaling, Degradation of the extracellular matrix, Developmental Biology, Disease, Diseases of signal transduction by growth factor receptors and second messengers, EPH-Ephrin signaling, EPH-ephrin mediated repulsion of cells, Extracellular matrix organization, Immune System, Innate Immune System, Metabolism of proteins, NOTCH2 Activation and Transmission of Signal to the Nucleus, NOTCH3 Activation and Transmission of Signal to the Nucleus, NOTCH4 Activation and Transmission of Signal to the Nucleus, NRIF signals cell death from the nucleus, Nervous system development, Neutrophil degranulation, Noncanonical activation of NOTCH3, Notch, Notch Signaling, Notch Signaling Pathway Netpath, Notch signaling pathway, Notch signaling pathway - Homo sapiens (human), Nuclear signaling by ERBB4, Presenilin action in Notch and Wnt signaling, Regulated proteolysis of p75NTR, Signal Transduction, Signaling by ERBB4, Signaling by NOTCH, Signaling by NOTCH1, Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer, Signaling by NOTCH1 PEST Domain Mutants in Cancer, Signaling by NOTCH1 in Cancer, Signaling by NOTCH2, Signaling by NOTCH3, Signaling by NOTCH4, Signaling by Receptor Tyrosine Kinases, Signaling by TGFB family members, Signaling by TGFBR3, Syndecan-3-mediated signaling events, TGFBR3 PTM regulation, p75 NTR receptor-mediated signalling, p75(NTR)-mediated signaling
UniProt: Q92542
Entrez ID: 23385
|
Does Knockout of CADM3 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 0
| 758
|
Knockout
|
CADM3
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: CADM3 (cell adhesion molecule 3)
Type: protein-coding
Summary: The protein encoded by this gene is a calcium-independent cell-cell adhesion protein that can form homodimers or heterodimers with other nectin proteins. The encoded protein has both homophilic and heterophilic cell-cell adhesion activity. This gene is reported to be a tumor suppressor gene. [provided by RefSeq, Oct 2016].
Gene Ontology: BP: cell adhesion, heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules, homophilic cell adhesion via plasma membrane adhesion molecules; MF: protein binding, protein homodimerization activity; CC: anchoring junction, cell-cell junction, membrane, plasma membrane, presynaptic membrane
Pathways: Adherens junctions interactions, Cell adhesion molecules - Homo sapiens (human), Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Nectin/Necl trans heterodimerization, Splicing factor NOVA regulated synaptic proteins
UniProt: Q8N126
Entrez ID: 57863
|
Does Knockout of IRF2 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 427
|
Knockout
|
IRF2
|
cell proliferation
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: IRF2 (interferon regulatory factor 2)
Type: protein-coding
Summary: IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cell population proliferation, defense response to virus, immune system process, negative regulation of transcription by RNA polymerase II, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, protein binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding; CC: chromatin, cytosol, focal adhesion, nucleoplasm, nucleus
Pathways: Apoptosis, Cytokine Signaling in Immune system, Factors involved in megakaryocyte development and platelet production, Hemostasis, Immune System, Interferon Signaling, Interferon alpha/beta signaling, Interferon gamma signaling, Programmed Cell Death, Pyroptosis, Regulated Necrosis, Type II interferon signaling (IFNG), the information processing pathway at the ifn beta enhancer
UniProt: P14316
Entrez ID: 3660
|
Does Knockout of MYRFL in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,340
|
Knockout
|
MYRFL
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: MYRFL (myelin regulatory factor like)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity and sequence-specific DNA binding activity. Predicted to be involved in positive regulation of transcription, DNA-templated and protein autoprocessing. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum membrane and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: positive regulation of DNA-templated transcription, protein autoprocessing, regulation of DNA-templated transcription; MF: DNA binding, DNA-binding transcription factor activity, sequence-specific DNA binding; CC: endoplasmic reticulum membrane, membrane, nucleus
Pathways:
UniProt: Q96LU7
Entrez ID: 196446
|
Does Knockout of RUBCNL in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,329
|
Knockout
|
RUBCNL
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: RUBCNL (rubicon like autophagy enhancer)
Type: protein-coding
Summary: This gene encodes a cysteine-rich protein that contains a putative zinc-RING and/or ribbon domain. The encoded protein is related to Run domain Beclin-1-interacting and cysteine-rich domain-containing protein, which plays a role in endocytic trafficking and autophagy. In cervical cancer cell lines, this gene is expressed at low levels and may function as a tumor suppressor. Promoter hypermethylation of this gene is observed in cervical cancer cell lines and tissue derived from human patients. [provided by RefSeq, Mar 2017].
Gene Ontology: BP: autophagosome maturation, autophagosome-endosome fusion, autophagosome-lysosome fusion, autophagy, lipid metabolic process, regulation of glycogen metabolic process, regulation of lipid metabolic process; MF: lipid binding, phosphatidylinositol phosphate binding, phosphatidylinositol-3-phosphate binding, phosphatidylinositol-4-phosphate binding, phosphatidylinositol-5-phosphate binding, protein binding; CC: autophagosome membrane, cytoplasmic vesicle, intracellular membrane-bounded organelle, membrane
Pathways:
UniProt: Q9H714
Entrez ID: 80183
|
Does Knockout of SNRNP35 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 427
|
Knockout
|
SNRNP35
|
cell proliferation
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: SNRNP35 (small nuclear ribonucleoprotein U11/U12 subunit 35)
Type: protein-coding
Summary: The protein encoded by this gene is a homolog of the U1-snRNP binding protein. The N-terminal half contains a RNA recognition motif and the C-terminal half is rich in Arg/Asp and Arg/Glu dipeptides, which is a characteristic of a variety of splicing factors. This protein is a component of the U11/U12 small nuclear ribonucleoproteins (snRNP) that form part of the U12-type spliceosome. Alternative splicing results in multiple transcript variants encoding two distinct isoforms and representing a non-protein coding variant. [provided by RefSeq, Aug 2013].
Gene Ontology: BP: RNA splicing, mRNA processing, mRNA splicing, via spliceosome; MF: RNA binding, mRNA binding, nucleic acid binding, protein binding, snRNA binding; CC: U12-type spliceosomal complex, nucleolus, nucleoplasm, nucleus, ribonucleoprotein complex, spliceosomal complex
Pathways:
UniProt: Q16560
Entrez ID: 11066
|
Does Knockout of CEP95 in Primary Effusion Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,061
|
Knockout
|
CEP95
|
response to chemicals
|
Primary Effusion Lymphoma Cell Line
|
Gene: CEP95 (centrosomal protein 95)
Type: protein-coding
Summary: Located in centrosome and spindle pole. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: centrosome, cytoplasm, cytoskeleton, spindle pole
Pathways:
UniProt: Q96GE4
Entrez ID: 90799
|
Does Knockout of PPRC1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,459
|
Knockout
|
PPRC1
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: PPRC1 (PPARG related coactivator 1)
Type: protein-coding
Summary: The protein encoded by this gene is similar to PPAR-gamma coactivator 1 (PPARGC1/PGC-1), a protein that can activate mitochondrial biogenesis in part through a direct interaction with nuclear respiratory factor 1 (NRF1). This protein has been shown to interact with NRF1. It is thought to be a functional relative of PPAR-gamma coactivator 1 that activates mitochondrial biogenesis through NRF1 in response to proliferative signals. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013].
Gene Ontology: BP: energy homeostasis, positive regulation of transcription by RNA polymerase II; MF: RNA binding, nucleic acid binding, transcription coactivator activity, transcription coregulator activity; CC: nucleoplasm, nucleus
Pathways: Energy Metabolism, Mitochondrial Gene Expression, Mitochondrial biogenesis, Organelle biogenesis and maintenance, Transcriptional activation of mitochondrial biogenesis
UniProt: Q5VV67
Entrez ID: 23082
|
Does Knockout of FCER2 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 815
|
Knockout
|
FCER2
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: FCER2 (Fc epsilon receptor II)
Type: protein-coding
Summary: The protein encoded by this gene is a B-cell specific antigen, and a low-affinity receptor for IgE. It has essential roles in B cell growth and differentiation, and the regulation of IgE production. This protein also exists as a soluble secreted form, then functioning as a potent mitogenic growth factor. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011].
Gene Ontology: BP: B cell antigen processing and presentation, Fc receptor-mediated immune complex endocytosis, Fc-epsilon receptor signaling pathway, Fc-gamma receptor signaling pathway involved in phagocytosis, defense response to bacterium, immune response, macrophage activation, positive regulation of gene expression, positive regulation of humoral immune response mediated by circulating immunoglobulin; MF: IgE binding, carbohydrate binding, integrin binding, low-affinity IgE receptor activity, metal ion binding, pattern recognition receptor activity, protease binding, protein binding; CC: external side of plasma membrane, extracellular exosome, extracellular region, membrane, plasma membrane
Pathways: Complement system, Cytokine Signaling in Immune system, Epstein-Barr virus infection - Homo sapiens (human), Hematopoietic cell lineage - Homo sapiens (human), IL4-mediated signaling events, Immune System, Interleukin-10 signaling, Interleukin-4 and Interleukin-13 signaling, NOTCH2 intracellular domain regulates transcription, Signal Transduction, Signaling by Interleukins, Signaling by NOTCH, Signaling by NOTCH2, il 4 signaling pathway
UniProt: P06734
Entrez ID: 2208
|
Does Knockout of TBC1D3C in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 206
|
Knockout
|
TBC1D3C
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: TBC1D3C (TBC1 domain family member 3C)
Type: protein-coding
Summary: This gene represents one of a cluster of related genes found on chromosome 17. The proteins encoded by this gene family contain a TBC (Tre-2, Bub2p, and Cdc16p) domain and may be involved in GTPase signaling and vesicle trafficking. [provided by RefSeq, Apr 2014].
Gene Ontology: MF: GTPase activator activity; CC: endosome, membrane, plasma membrane
Pathways: Membrane Trafficking, Rab regulation of trafficking, TBC/RABGAPs, Vesicle-mediated transport
UniProt: Q6IPX1, Q8IZP1
Entrez ID: 414060
|
Does Knockout of ACTR1B in Ovarian Cancer Cell Line causally result in cell proliferation?
| 0
| 699
|
Knockout
|
ACTR1B
|
cell proliferation
|
Ovarian Cancer Cell Line
|
Gene: ACTR1B (actin related protein 1B)
Type: protein-coding
Summary: This gene encodes a 42.3 kD subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein and is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like ACTR1A, is an actin-related protein. These two proteins, which are of equal length and share 90% amino acid identity, are present in a constant ratio of approximately 1:15 in the dynactin complex. [provided by RefSeq, Aug 2008].
Gene Ontology: MF: ATP binding, nucleotide binding, protein binding; CC: centrosome, cytoplasm, cytoskeleton, cytosol, dynactin complex, extracellular exosome, extracellular region, ficolin-1-rich granule lumen, membrane, microtubule organizing center, secretory granule lumen
Pathways: Adaptive Immune System, Amyotrophic lateral sclerosis - Homo sapiens (human), Huntington disease - Homo sapiens (human), Immune System, Innate Immune System, MHC class II antigen presentation, Neutrophil degranulation, Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Salmonella infection - Homo sapiens (human)
UniProt: P42025
Entrez ID: 10120
|
Does Knockout of B4GALT4 in Bladder Carcinoma causally result in cell proliferation?
| 0
| 489
|
Knockout
|
B4GALT4
|
cell proliferation
|
Bladder Carcinoma
|
Gene: B4GALT4 (beta-1,4-galactosyltransferase 4)
Type: protein-coding
Summary: This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme encoded by this gene appears to mainly play a role in glycolipid biosynthesis. Two alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: carbohydrate metabolic process, glycosylation, keratan sulfate proteoglycan biosynthetic process, lactosylceramide biosynthetic process, lipid metabolic process, membrane lipid metabolic process, protein glycosylation; MF: N-acetyllactosamine synthase activity, UDP-galactosyltransferase activity, galactosyltransferase activity, glycosyltransferase activity, metal ion binding, protein binding, transferase activity; CC: Golgi apparatus, Golgi membrane, extracellular region, membrane
Pathways: Asparagine N-linked glycosylation, Glycosaminoglycan biosynthesis - keratan sulfate - Homo sapiens (human), Glycosaminoglycan metabolism, Glycosphingolipid biosynthesis - lacto and neolacto series - Homo sapiens (human), Keratan sulfate biosynthesis, Keratan sulfate/keratin metabolism, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of proteins, N-Glycan antennae elongation, N-glycan antennae elongation in the medial/trans-Golgi, Post-translational protein modification, Transport to the Golgi and subsequent modification
UniProt: O60513
Entrez ID: 8702
|
Does Knockout of ZNF575 in Diffuse Large B-cell Lymphoma Cell causally result in response to chemicals?
| 0
| 2,222
|
Knockout
|
ZNF575
|
response to chemicals
|
Diffuse Large B-cell Lymphoma Cell
|
Gene: ZNF575 (zinc finger protein 575)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding, zinc ion binding
Pathways:
UniProt: Q86XF7
Entrez ID: 284346
|
Does Knockout of IARS2 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 287
|
Knockout
|
IARS2
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: IARS2 (isoleucyl-tRNA synthetase 2, mitochondrial)
Type: protein-coding
Summary: Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAS, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of isoleucine-tRNA synthetase exist, a cytoplasmic form and a mitochondrial form. This gene encodes the mitochondrial isoleucine-tRNA synthetase which belongs to the class-I aminoacyl-tRNA synthetase family. [provided by RefSeq, Dec 2014].
Gene Ontology: BP: aminoacyl-tRNA metabolism involved in translational fidelity, isoleucyl-tRNA aminoacylation, mitochondrial translation, tRNA aminoacylation for protein translation, translation; MF: ATP binding, aminoacyl-tRNA deacylase activity, aminoacyl-tRNA ligase activity, isoleucine-tRNA ligase activity, ligase activity, nucleotide binding, tRNA binding; CC: mitochondrial matrix, mitochondrion
Pathways: Aminoacyl-tRNA biosynthesis - Homo sapiens (human), Metabolism of proteins, Mitochondrial protein degradation, Mitochondrial tRNA aminoacylation, Translation, tRNA Aminoacylation, tRNA charging
UniProt: Q9NSE4
Entrez ID: 55699
|
Does Knockout of MRGBP in Neuroblastoma Cell Line causally result in cell proliferation?
| 1
| 824
|
Knockout
|
MRGBP
|
cell proliferation
|
Neuroblastoma Cell Line
|
Gene: MRGBP (MRG domain binding protein)
Type: protein-coding
Summary: Predicted to be involved in histone acetylation and regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: chromatin organization, positive regulation of DNA-templated transcription, positive regulation of double-strand break repair via homologous recombination, regulation of DNA-templated transcription, regulation of apoptotic process, regulation of cell cycle, regulation of double-strand break repair, regulation of transcription by RNA polymerase II; CC: H4/H2A histone acetyltransferase complex, NuA4 histone acetyltransferase complex, nucleoplasm, nucleosome, nucleus
Pathways: Chromatin modifying enzymes, Chromatin organization, HATs acetylate histones
UniProt: Q9NV56
Entrez ID: 55257
|
Does Knockout of DPEP3 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 305
|
Knockout
|
DPEP3
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: DPEP3 (dipeptidase 3)
Type: protein-coding
Summary: This gene encodes a membrane-bound glycoprotein from the family of dipeptidases involved in hydrolytic metabolism of various dipeptides, including penem and carbapenem beta-lactam antibiotics. This gene is located on chromosome 16 in a cluster with another member of this family. Alternatively spliced transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: leukotriene D4 catabolic process, proteolysis; MF: dipeptidase activity, peptidase activity; CC: acrosomal vesicle, membrane, plasma membrane, side of membrane
Pathways:
UniProt: Q9H4B8
Entrez ID: 64180
|
Does Knockout of GTF2B in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 865
|
Knockout
|
GTF2B
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: GTF2B (general transcription factor IIB)
Type: protein-coding
Summary: This gene encodes the general transcription factor IIB, one of the ubiquitous factors required for transcription initiation by RNA polymerase II. The protein localizes to the nucleus where it forms a complex (the DAB complex) with transcription factors IID and IIA. Transcription factor IIB serves as a bridge between IID, the factor which initially recognizes the promoter sequence, and RNA polymerase II. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA-templated transcription initiation, RNA polymerase II core complex assembly, RNA polymerase II preinitiation complex assembly, chromatin remodeling, chromosome organization, gene expression, meiotic sister chromatid cohesion, positive regulation of core promoter binding, protein acetylation, spindle assembly, transcription by RNA polymerase II, transcription initiation at RNA polymerase II promoter, transcription preinitiation complex assembly, transcriptional start site selection at RNA polymerase II promoter, viral transcription; MF: DNA binding, DNA-binding transcription factor binding, RNA polymerase II complex binding, RNA polymerase II core promoter sequence-specific DNA binding, RNA polymerase II general transcription initiation factor activity, TBP-class protein binding, acetyltransferase activity, acyltransferase activity, histone acetyltransferase activity, metal ion binding, nuclear thyroid hormone receptor binding, promoter-specific chromatin binding, protein binding, protein-lysine-acetyltransferase activity, transferase activity, zinc ion binding; CC: RNA polymerase II transcription regulator complex, cell division site, chromosome, condensed chromosome, germinal vesicle, kinetochore, nuclear body, nucleoplasm, nucleus, protein-DNA complex, transcription factor TFIID complex, transcription preinitiation complex
Pathways: Basal transcription factors - Homo sapiens (human), Disease, Eukaryotic Transcription Initiation, Gene expression (Transcription), HIV Infection, HIV Life Cycle, HIV Transcription Initiation, Infectious disease, Late Phase of HIV Life Cycle, RNA Polymerase II HIV Promoter Escape, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Promoter Escape, RNA Polymerase II Transcription, RNA Polymerase II Transcription Initiation, RNA Polymerase II Transcription Initiation And Promoter Clearance, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, RNA polymerase II transcribes snRNA genes, Spinocerebellar ataxia - Homo sapiens (human), Transcription of the HIV genome, Viral Infection Pathways, Viral carcinogenesis - Homo sapiens (human), chromatin remodeling by hswi/snf atp-dependent complexes, the information processing pathway at the ifn beta enhancer
UniProt: Q00403
Entrez ID: 2959
|
Does Knockout of GINS1 in Cancer Cell Line causally result in cell proliferation?
| 1
| 948
|
Knockout
|
GINS1
|
cell proliferation
|
Cancer Cell Line
|
Gene: GINS1 (GINS complex subunit 1)
Type: protein-coding
Summary: The yeast heterotetrameric GINS complex is made up of Sld5 (GINS4; MIM 610611), Psf1, Psf2 (GINS2; MIM 610609), and Psf3 (GINS3; MIM 610610). The formation of the GINS complex is essential for the initiation of DNA replication in yeast and Xenopus egg extracts (Ueno et al., 2005 [PubMed 16287864]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: DNA replication, DNA strand elongation involved in mitotic DNA replication, inner cell mass cell proliferation; CC: CMG complex, GINS complex, chromosome, cytoplasm, nucleoplasm, nucleus
Pathways: Cell Cycle, Cell Cycle, Mitotic, DNA Replication, DNA strand elongation, S Phase, Synthesis of DNA, Unwinding of DNA
UniProt: Q14691
Entrez ID: 9837
|
Does Knockout of TAF10 in Bladder Carcinoma causally result in cell proliferation?
| 1
| 489
|
Knockout
|
TAF10
|
cell proliferation
|
Bladder Carcinoma
|
Gene: TAF10 (TATA-box binding protein associated factor 10)
Type: protein-coding
Summary: Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the small subunits of TFIID that is associated with a subset of TFIID complexes. Studies with human and mammalian cells have shown that this subunit is required for transcriptional activation by the estrogen receptor, for progression through the cell cycle, and may also be required for certain cellular differentiation programs. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA-templated transcription initiation, G1/S transition of mitotic cell cycle, RNA polymerase II preinitiation complex assembly, SAGA complex assembly, allantois development, apoptotic process, chromatin remodeling, embryonic placenta development, gene expression, hepatocyte differentiation, in utero embryonic development, lateral mesodermal cell differentiation, limb development, liver development, mRNA transcription by RNA polymerase II, multicellular organism growth, positive regulation of DNA-templated transcription, positive regulation of transcription initiation by RNA polymerase II, protein-containing complex assembly, regulation of DNA repair, regulation of DNA-templated transcription, regulation of RNA splicing, regulation of gene expression, regulation of transcription by RNA polymerase II, somitogenesis, transcription by RNA polymerase II, transcription initiation at RNA polymerase II promoter; MF: DNA binding, RNA polymerase II general transcription initiation factor activity, RNA polymerase binding, enzyme binding, histone acetyltransferase activity, identical protein binding, nuclear estrogen receptor binding, promoter-specific chromatin binding, protein binding; CC: SAGA complex, cytoplasm, male germ cell nucleus, nucleoplasm, nucleus, perinuclear region of cytoplasm, transcription factor TFIID complex, transcription factor TFTC complex, transcription preinitiation complex
Pathways: Basal transcription factors - Homo sapiens (human), C-MYC pathway, Chromatin modifying enzymes, Chromatin organization, Deubiquitination, Disease, Gene expression (Transcription), Generic Transcription Pathway, HATs acetylate histones, HIV Infection, HIV Life Cycle, HIV Transcription Initiation, Infectious disease, Late Phase of HIV Life Cycle, Metabolism of proteins, Post-translational protein modification, RNA Polymerase II HIV Promoter Escape, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Promoter Escape, RNA Polymerase II Transcription, RNA Polymerase II Transcription Initiation, RNA Polymerase II Transcription Initiation And Promoter Clearance, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Transcription of the HIV genome, Transcriptional Regulation by TP53, Ub-specific processing proteases, Validated targets of C-MYC transcriptional activation, Viral Infection Pathways
UniProt: Q12962
Entrez ID: 6881
|
Does Knockout of SPRR1B in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 951
|
Knockout
|
SPRR1B
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: SPRR1B (small proline rich protein 1B)
Type: protein-coding
Summary: The protein encoded by this gene is an envelope protein of keratinocytes. The encoded protein is crosslinked to membrane proteins by transglutaminase, forming an insoluble layer under the plasma membrane. This protein is proline-rich and contains several tandem amino acid repeats. [provided by RefSeq, Nov 2015].
Gene Ontology: BP: epidermis development, keratinization, keratinocyte differentiation, peptide cross-linking; CC: cornified envelope, cytoplasm, cytosol
Pathways: Developmental Biology, Formation of the cornified envelope, Keratinization, Vitamin D Receptor Pathway
UniProt: P22528
Entrez ID: 6699
|
Does Knockout of GPR34 in Colorectal Cancer Cell Line causally result in cell proliferation?
| 0
| 783
|
Knockout
|
GPR34
|
cell proliferation
|
Colorectal Cancer Cell Line
|
Gene: GPR34 (G protein-coupled receptor 34)
Type: protein-coding
Summary: G protein-coupled receptors (GPCRs), such as GPR34, are integral membrane proteins containing 7 putative transmembrane domains (TMs). These proteins mediate signals to the interior of the cell via activation of heterotrimeric G proteins that in turn activate various effector proteins, ultimately resulting in a physiologic response.[supplied by OMIM, Apr 2006].
Gene Ontology: BP: G protein-coupled purinergic nucleotide receptor signaling pathway, G protein-coupled receptor signaling pathway, signal transduction; MF: G protein-coupled purinergic nucleotide receptor activity, G protein-coupled receptor activity; CC: membrane, plasma membrane
Pathways: GPCRs, Class A Rhodopsin-like
UniProt: Q9UPC5
Entrez ID: 2857
|
Does Knockout of KRT6C in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 0
| 1,246
|
Knockout
|
KRT6C
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: KRT6C (keratin 6C)
Type: protein-coding
Summary: Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. The type II keratins are clustered in a region of chromosome 12q13. [provided by RefSeq, Jul 2009].
Gene Ontology: BP: intermediate filament cytoskeleton organization, intermediate filament organization, keratinization; MF: protein binding, structural constituent of skin epidermis; CC: cytosol, extracellular exosome, intermediate filament, keratin filament
Pathways: Developmental Biology, Formation of the cornified envelope, Keratinization
UniProt: P48668
Entrez ID: 286887
|
Does Knockout of AKAP3 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,996
|
Knockout
|
AKAP3
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: AKAP3 (A-kinase anchoring protein 3)
Type: protein-coding
Summary: This gene encodes a member of A-kinase anchoring proteins (AKAPs), a family of functionally related proteins that target protein kinase A to discrete locations within the cell. The encoded protein is reported to participate in protein-protein interactions with the R-subunit of the protein kinase A as well as sperm-associated proteins. This protein is expressed in spermatozoa and localized to the acrosomal region of the sperm head as well as the length of the principal piece. It may function as a regulator of motility, capacitation, and the acrosome reaction. [provided by RefSeq, May 2013].
Gene Ontology: BP: acrosome reaction, blastocyst hatching, cell surface receptor protein serine/threonine kinase signaling pathway, establishment of protein localization, flagellated sperm motility, intracellular protein localization, single fertilization; MF: protein binding, protein kinase A binding; CC: acrosomal vesicle, cell projection, cilium, cytoplasm, cytoplasmic vesicle, motile cilium, nucleus, sperm fibrous sheath, sperm midpiece, sperm principal piece
Pathways: G Protein Signaling Pathways
UniProt: O75969
Entrez ID: 10566
|
Does Knockout of CERS1 in Glioblastoma Cell Line causally result in cell proliferation?
| 0
| 906
|
Knockout
|
CERS1
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: CERS1 (ceramide synthase 1)
Type: protein-coding
Summary: This gene encodes a ceramide synthase enzyme, which catalyzes the synthesis of ceramide, the hydrophobic moiety of sphingolipids. The encoded enzyme synthesizes 18-carbon (C18) ceramide in brain neurons. Elevated expression of this gene may be associated with increased longevity, while decreased expression of this gene may be associated with myoclonus epilepsy with dementia in human patients. This protein is transcribed from a monocistronic mRNA as well as a bicistronic mRNA, which also encodes growth differentiation factor 1. [provided by RefSeq, Jul 2016].
Gene Ontology: BP: brain development, cellular response to UV-A, cellular response to dithiothreitol, cellular response to mycotoxin, cellular response to xenobiotic stimulus, ceramide biosynthetic process, lipid metabolic process, negative regulation of D-glucose import, negative regulation of cardiac muscle hypertrophy, positive regulation of mitophagy, sphingolipid biosynthetic process, sphingolipid metabolic process; MF: N-acyltransferase activity, sphingosine N-acyltransferase activity, transferase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, intracellular membrane-bounded organelle, membrane
Pathways: Metabolism, Metabolism of lipids, Sphingolipid Metabolism (general overview), Sphingolipid Metabolism (integrated pathway), Sphingolipid de novo biosynthesis, Sphingolipid metabolism, Sphingolipid metabolism - Homo sapiens (human), Sphingolipid signaling pathway - Homo sapiens (human), ceramide <i>de novo</i> biosynthesis
UniProt: P27544
Entrez ID: 10715
|
Does Knockout of TEX10 in Urinary Bladder Cancer Cell Line causally result in cell proliferation?
| 1
| 180
|
Knockout
|
TEX10
|
cell proliferation
|
Urinary Bladder Cancer Cell Line
|
Gene: TEX10 (testis expressed 10)
Type: protein-coding
Summary: Located in mitochondrion and nucleoplasm. Part of MLL1 complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: MLL1 complex, cytoplasm, mitochondrion, nucleolus, nucleoplasm, nucleus
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9NXF1
Entrez ID: 54881
|
Does Knockout of TNFRSF14 in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 0
| 2,430
|
Knockout
|
TNFRSF14
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: TNFRSF14 (TNF receptor superfamily member 14)
Type: protein-coding
Summary: This gene encodes a member of the TNF (tumor necrosis factor) receptor superfamily. The encoded protein functions in signal transduction pathways that activate inflammatory and inhibitory T-cell immune response. It binds herpes simplex virus (HSV) viral envelope glycoprotein D (gD), mediating its entry into cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].
Gene Ontology: BP: T cell costimulation, adaptive immune response, cell surface receptor signaling pathway, defense response to Gram-negative bacterium, defense response to Gram-positive bacterium, immune response, immune system process, innate immune response, negative regulation of T cell proliferation, negative regulation of adaptive immune memory response, negative regulation of alpha-beta T cell proliferation, positive regulation of T cell migration, positive regulation of cytokine production involved in immune response, symbiont entry into host cell, tumor necrosis factor-mediated signaling pathway; MF: cytokine binding, protein binding, receptor ligand activity, tumor necrosis factor receptor activity, ubiquitin protein ligase binding, virus receptor activity; CC: external side of plasma membrane, membrane, plasma membrane
Pathways: Adaptive Immune System, Co-inhibition by BTLA, Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Homo sapiens (human), Herpes simplex virus 1 infection - Homo sapiens (human), Immune System, Regulation of T cell activation by CD28 family, TNFR2 non-canonical NF-kB pathway, TNFs bind their physiological receptors, Viral protein interaction with cytokine and cytokine receptor - Homo sapiens (human)
UniProt: Q92956
Entrez ID: 8764
|
Does Knockout of PGAP2 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 334
|
Knockout
|
PGAP2
|
cell proliferation
|
Esophageal Squamous Cell Carcinoma Cell Line
|
Gene: PGAP2 (post-GPI attachment to proteins 2)
Type: protein-coding
Summary: The protein encoded by this gene plays a role in the maturation of glycosylphosphatidylinositol (GPI) anchors on GPI-anchored proteins. Mutations in this gene are associated with an autosomal recessive syndrome characterized by hyperphosphatasia and intellectual disability. [provided by RefSeq, Jul 2017].
Gene Ontology: BP: GPI anchor biosynthetic process; MF: protein binding, transferase activity; CC: Golgi apparatus, Golgi membrane, endoplasmic reticulum membrane, membrane
Pathways:
UniProt: Q9UHJ9
Entrez ID: 27315
|
Does Knockout of SLC39A14 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 206
|
Knockout
|
SLC39A14
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: SLC39A14 (solute carrier family 39 member 14)
Type: protein-coding
Summary: This gene encodes a member of the the SLC39A family of divalent metal transporters that mediates the cellular uptake of manganese, zinc, iron, and cadmium. The encoded protein contains eight transmembrane domains, a histidine-rich motif, and a metalloprotease motif, and is expressed on the plasma membrane and the endocytic vesicle membrane. It is an important transporter of nontransferrin-bound iron and a critical regulator of manganese homeostasis. Naturally occurring mutations in this gene are associated with neurodegeneration with brain iron accumulation and early-onset parkinsonism-dystonia with hypermanganesemia. [provided by RefSeq, May 2017].
Gene Ontology: BP: bicarbonate transport, cadmium ion transmembrane transport, cellular response to glucose stimulus, cellular response to insulin stimulus, chondrocyte differentiation, gluconeogenesis, import across plasma membrane, inorganic cation transmembrane transport, insulin receptor signaling pathway, intracellular monoatomic cation homeostasis, intracellular zinc ion homeostasis, iron import into cell, iron ion transmembrane transport, iron ion transport, manganese ion homeostasis, manganese ion transmembrane transport, metal ion transport, monoatomic anion transmembrane transport, monoatomic ion transport, positive regulation of G protein-coupled receptor signaling pathway, regulation of hormone levels, transmembrane transport, zinc ion import across plasma membrane, zinc ion transmembrane transport, zinc ion transport; MF: cadmium ion transmembrane transporter activity, ferrous iron transmembrane transporter activity, iron ion transmembrane transporter activity, manganese ion transmembrane transporter activity, metal ion transmembrane transporter activity, monoatomic anion:monoatomic cation symporter activity, monoatomic cation:bicarbonate symporter activity, protein binding, zinc ion transmembrane transporter activity; CC: apical plasma membrane, basolateral plasma membrane, early endosome membrane, endosome, late endosome membrane, lysosomal membrane, lysosome, membrane, plasma membrane
Pathways: Ferroptosis, Ferroptosis - Homo sapiens (human), Metal ion SLC transporters, NRF2 pathway, Nuclear Receptors Meta-Pathway, SLC-mediated transmembrane transport, Transport of small molecules, Zinc homeostasis, Zinc influx into cells by the SLC39 gene family, Zinc transporters
UniProt: Q15043
Entrez ID: 23516
|
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