prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Klrb1c in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Klrb1c
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Klrb1c (killer cell lectin-like receptor subfamily B member 1C)
Type: protein-coding
Summary: Enables identical protein binding activity and signaling receptor activity. Acts upstream of or within natural killer cell activation and positive regulation of natural killer cell mediated cytotoxicity. Located in external side of plasma membrane. Is expressed in thymus primordium. Orthologous to human KLRB1 (killer cell lectin like receptor B1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: natural killer cell activation, positive regulation of natural killer cell mediated cytotoxicity, regulation of natural killer cell mediated cytotoxicity; MF: carbohydrate binding, identical protein binding, signaling receptor activity; CC: cell surface, external side of plasma membrane, membrane, plasma membrane
Pathways: Malaria - Mus musculus (mouse), Natural killer cell mediated cytotoxicity - Mus musculus (mouse)
UniProt: P27814
Entrez ID: 17059
|
Does Knockout of Ciao1 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Ciao1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Ciao1 (cytosolic iron-sulfur protein assembly 1)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity. Predicted to be involved in iron-sulfur cluster assembly and protein maturation. Predicted to act upstream of or within regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm. Predicted to be part of MMXD complex and cytosolic [4Fe-4S] assembly targeting complex. Is expressed in several structures, including central nervous system; genitourinary system; liver; neural retina; and skin. Orthologous to human CIAO1 (cytosolic iron-sulfur assembly component 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: chromosome segregation, iron-sulfur cluster assembly, protein maturation, regulation of transcription by RNA polymerase II; CC: MMXD complex, cytoplasm, cytosolic [4Fe-4S] assembly targeting complex
Pathways:
UniProt: Q99KN2
Entrez ID: 26371
|
Does Knockout of Cdr2l in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Cdr2l
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Cdr2l (cerebellar degeneration-related protein 2-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: identical protein binding, molecular_function
Pathways:
UniProt: A2A6T1
Entrez ID: 237988
|
Does Knockout of Tsga10ip in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Tsga10ip
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Tsga10ip (testis specific 10 interacting protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cytoskeleton, photoreceptor connecting cilium
Pathways:
UniProt:
Entrez ID: 78306
|
Does Knockout of Plekhg2 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Plekhg2
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Plekhg2 (pleckstrin homology domain containing, family G (with RhoGef domain) member 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of actin filament polymerization; MF: guanyl-nucleotide exchange factor activity, small GTPase binding
Pathways: CDC42 GTPase cycle, Cell death signalling via NRAGE, NRIF and NADE, Death Receptor Signaling, G alpha (12/13) signalling events, GPCR downstream signalling, NRAGE signals death through JNK, RAC1 GTPase cycle, RHO GTPase cycle, Signal Transduction, Signaling by GPCR, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, p75 NTR receptor-mediated signalling
UniProt: Q6KAU7
Entrez ID: 101497
|
Does Knockout of Intu in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Intu
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Intu (inturned planar cell polarity protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell projection organization, cilium assembly, embryonic digit morphogenesis, establishment of planar polarity, hair follicle morphogenesis, intraciliary transport, keratinocyte differentiation, limb development, motile cilium assembly, negative regulation of cell division, negative regulation of keratinocyte proliferation, nervous system development, neural tube development, non-motile cilium assembly, positive regulation of smoothened signaling pathway, regulation of cilium assembly, regulation of ossification, regulation of smoothened signaling pathway, roof of mouth development, spinal cord dorsal/ventral patterning, tongue morphogenesis, vesicle-mediated transport; MF: phosphatidylinositol binding, protein binding; CC: cell projection, cell surface, centriole, ciliary basal body, ciliary transition zone, cilium, cytoplasm, cytoskeleton, cytosol, motile cilium
Pathways: Hedgehog 'off' state, Signal Transduction, Signaling by Hedgehog
UniProt: Q059U7
Entrez ID: 380614
|
Does Knockout of Taf6l in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Taf6l
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Taf6l (TATA-box binding protein associated factor 6 like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA polymerase II preinitiation complex assembly, positive regulation of DNA-templated transcription, regulation of DNA repair, regulation of DNA-templated transcription, regulation of RNA splicing, regulation of somatic stem cell population maintenance, transcription initiation at RNA polymerase II promoter; MF: RNA polymerase II general transcription initiation factor activity, protein heterodimerization activity, transcription coactivator activity; CC: SAGA complex, SLIK (SAGA-like) complex, nucleoplasm, nucleus, transcription factor TFIID complex
Pathways: Basal transcription factors - Mus musculus (mouse)
UniProt: Q8R2K4
Entrez ID: 225895
|
Does Knockout of Psmd4 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 579
|
Knockout
|
Psmd4
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Psmd4 (proteasome (prosome, macropain) 26S subunit, non-ATPase, 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: identical protein binding, molecular adaptor activity, polyubiquitin modification-dependent protein binding; CC: cytosol, nucleoplasm, nucleus, proteasome accessory complex, proteasome complex, proteasome regulatory particle, base subcomplex
Pathways: Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Epstein-Barr virus infection - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Metabolism of proteins, Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Post-translational protein modification, Prion disease - Mus musculus (mouse), Proteasome - Mus musculus (mouse), Proteasome assembly, Spinocerebellar ataxia - Mus musculus (mouse), Targeted protein degradation
UniProt: O35226
Entrez ID: 19185
|
Does Knockout of Psmb8 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,273
|
Knockout
|
Psmb8
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Psmb8 (proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: antigen processing and presentation, cell differentiation, fat cell differentiation, immune system process, proteasome-mediated ubiquitin-dependent protein catabolic process, proteolysis, proteolysis involved in protein catabolic process; MF: endopeptidase activity, hydrolase activity, peptidase activity, protein binding, threonine-type endopeptidase activity; CC: cytoplasm, cytosol, nucleoplasm, nucleus, proteasome complex, proteasome core complex, proteasome core complex, beta-subunit complex, spermatoproteasome complex
Pathways: Adaptive Immune System, Antigen processing-Cross presentation, Antigen processing: Ub, ATP-independent proteasomal degradation, Class I MHC mediated antigen processing & presentation, Cross-presentation of soluble exogenous antigens (endosomes), ER-Phagosome pathway, Immune System, Metabolism of proteins, Post-translational protein modification, Proteasome - Mus musculus (mouse), Proteasome assembly, Targeted protein degradation
UniProt: P28063
Entrez ID: 16913
|
Does Knockout of Tcp11l1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Tcp11l1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Tcp11l1 (t-complex 11 like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: microtubule
Pathways:
UniProt: Q8BTG3
Entrez ID: 320554
|
Does Knockout of Slmap in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 161
|
Knockout
|
Slmap
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Slmap (sarcolemma associated protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: hippo signaling, negative regulation of hippo signaling, protein localization to plasma membrane, regulation of membrane depolarization during cardiac muscle cell action potential, regulation of sodium ion transmembrane transport; MF: protein binding, protein-macromolecule adaptor activity; CC: FAR/SIN/STRIPAK complex, M band, Z disc, centrosome, cytoplasm, cytoskeleton, endoplasmic reticulum, endoplasmic reticulum membrane, extracellular space, membrane, mitochondrial membrane, mitochondrion, plasma membrane, sarcolemma
Pathways:
UniProt: Q3URD3
Entrez ID: 83997
|
Does Knockout of Itgb1 in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Itgb1
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Itgb1 (integrin beta 1 (fibronectin receptor beta))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CD40 signaling pathway, G1/S transition of mitotic cell cycle, angiogenesis, axon extension, basement membrane organization, bicellular tight junction assembly, calcium-independent cell-matrix adhesion, cardiac cell fate specification, cardiac muscle cell differentiation, cardiac muscle cell myoblast differentiation, cardiac muscle tissue development, cell adhesion, cell adhesion mediated by integrin, cell migration, cell migration involved in sprouting angiogenesis, cell projection organization, cell-cell adhesion, cell-cell adhesion mediated by integrin, cell-matrix adhesion, cell-substrate adhesion, cellular response to low-density lipoprotein particle stimulus, central nervous system neuron differentiation, dendrite morphogenesis, endocytosis, establishment of mitotic spindle orientation, fibroblast migration, formation of radial glial scaffolds, germ cell migration, heterotypic cell-cell adhesion, in utero embryonic development, integrin-mediated signaling pathway, lamellipodium assembly, leukocyte cell-cell adhesion, leukocyte tethering or rolling, maintenance of postsynaptic specialization structure, mesodermal cell differentiation, modulation of chemical synaptic transmission, muscle organ development, myoblast differentiation, myoblast fate specification, myoblast fusion, negative regulation of Rho protein signal transduction, negative regulation of anoikis, negative regulation of apoptotic process, negative regulation of autophagy, negative regulation of cell population proliferation, negative regulation of cell projection organization, negative regulation of neuron differentiation, negative regulation of vasoconstriction, neuron projection development, phagocytosis, positive regulation of angiogenesis, positive regulation of apoptotic process, positive regulation of cell migration, positive regulation of cell-substrate adhesion, positive regulation of developmental process, positive regulation of endocytosis, positive regulation of fibroblast growth factor receptor signaling pathway, positive regulation of fibroblast migration, positive regulation of glutamate uptake involved in transmission of nerve impulse, positive regulation of neuroblast proliferation, positive regulation of neuron differentiation, positive regulation of neuron projection development, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of protein localization to plasma membrane, positive regulation of vascular endothelial growth factor signaling pathway, positive regulation of wound healing, protein transport within lipid bilayer, reactive gliosis, receptor internalization, regulation of G protein-coupled receptor signaling pathway, regulation of biological quality, regulation of cell cycle, regulation of cell population proliferation, regulation of collagen catabolic process, regulation of neurotransmitter uptake, regulation of postsynaptic neurotransmitter receptor diffusion trapping, regulation of spontaneous synaptic transmission, regulation of synapse pruning, response to activity, response to muscle activity, response to radiation, sarcomere organization, stress fiber assembly, tissue development, tissue homeostasis, transforming growth factor beta receptor signaling pathway, visual learning; MF: C-X3-C chemokine binding, actin binding, alpha-actinin binding, calcium ion binding, cell adhesion molecule binding, collagen binding, collagen binding involved in cell-matrix adhesion, fibronectin binding, integrin binding, integrin binding involved in cell-matrix adhesion, kinase binding, laminin binding, magnesium ion binding, metal ion binding, protease binding, protein binding, protein domain specific binding, protein heterodimerization activity, protein kinase binding, protein tyrosine kinase binding, protein-containing complex binding, signaling receptor activity, signaling receptor binding; CC: Schaffer collateral - CA1 synapse, acrosomal vesicle, adherens junction, anchoring junction, basement membrane, cell projection, cell surface, cell-cell junction, cerebellar climbing fiber to Purkinje cell synapse, cytoplasm, cytoplasmic vesicle, dendritic spine, endosome, external side of plasma membrane, filopodium, focal adhesion, glial cell projection, glutamatergic synapse, glycinergic synapse, hemidesmosome, integrin alpha1-beta1 complex, integrin alpha10-beta1 complex, integrin alpha11-beta1 complex, integrin alpha2-beta1 complex, integrin alpha3-beta1 complex, integrin alpha4-beta1 complex, integrin alpha5-beta1 complex, integrin alpha6-beta1 complex, integrin alpha7-beta1 complex, integrin alpha9-beta1 complex, integrin alphav-beta1 complex, integrin complex, intercalated disc, lamellipodium, melanosome, membrane, membrane raft, myelin sheath abaxonal region, neuromuscular junction, perinuclear region of cytoplasm, plasma membrane, postsynaptic membrane, receptor complex, recycling endosome, ruffle, ruffle membrane, sarcolemma, synapse, synaptic membrane
Pathways: Adaptive Immune System, Arrhythmogenic right ventricular cardiomyopathy - Mus musculus (mouse), Axon guidance, Axon guidance - Mus musculus (mouse), Bacterial invasion of epithelial cells - Mus musculus (mouse), Basigin interactions, Cell adhesion molecules - Mus musculus (mouse), Cell junction organization, Cell surface interactions at the vascular wall, Cell-Cell communication, Cell-extracellular matrix interactions, Cellular responses to mechanical stimuli, Cellular responses to stimuli, Developmental Biology, Dilated cardiomyopathy - Mus musculus (mouse), ECM proteoglycans, ECM-receptor interaction - Mus musculus (mouse), Elastic fibre formation, Extracellular matrix organization, Fibronectin matrix formation, Focal adhesion - Mus musculus (mouse), G alpha (s) signalling events, GPCR downstream signalling, GPER1 signaling, Hemostasis, Human papillomavirus infection - Mus musculus (mouse), Hypertrophic cardiomyopathy - Mus musculus (mouse), Immune System, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, Integrin cell surface interactions, L1CAM interactions, Laminin interactions, Leishmaniasis - Mus musculus (mouse), Leukocyte transendothelial migration - Mus musculus (mouse), Localization of the PINCH-ILK-PARVIN complex to focal adhesions, MET activates PTK2 signaling, MET interacts with TNS proteins, MET promotes cell motility, Molecules associated with elastic fibres, Nervous system development, Non-integrin membrane-ECM interactions, PI3K-Akt signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Pertussis - Mus musculus (mouse), Phagosome - Mus musculus (mouse), Platelet activation - Mus musculus (mouse), Proteoglycans in cancer - Mus musculus (mouse), RAC1 GTPase cycle, RAC2 GTPase cycle, RAC3 GTPase cycle, RHO GTPase cycle, RHOG GTPase cycle, Rap1 signaling pathway - Mus musculus (mouse), Regulation of actin cytoskeleton - Mus musculus (mouse), Response of endothelial cells to shear stress, Signal Transduction, Signal transduction by L1, Signaling by GPCR, Signaling by MET, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by TGF-beta Receptor Complex, Signaling by TGFB family members, Small cell lung cancer - Mus musculus (mouse), Syndecan interactions, TGF-beta receptor signaling activates SMADs, Tight junction - Mus musculus (mouse), Toxoplasmosis - Mus musculus (mouse), Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells, Yersinia infection - Mus musculus (mouse)
UniProt: P09055
Entrez ID: 16412
|
Does Knockout of Ash2l in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Ash2l
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Ash2l (ASH2 like histone lysine methyltransferase complex subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, chromatin organization, positive regulation of cell population proliferation, positive regulation of macromolecule biosynthetic process, positive regulation of transcription by RNA polymerase II, regulation of gene expression, response to estrogen, transcription initiation-coupled chromatin remodeling; MF: DNA binding, beta-catenin binding, histone H3K4 methyltransferase activity, metal ion binding, protein binding, transcription cis-regulatory region binding, zinc ion binding; CC: MLL1 complex, MLL1/2 complex, MLL3/4 complex, Set1C/COMPASS complex, euchromatin, histone methyltransferase complex, nucleoplasm, nucleus
Pathways: Chromatin modifying enzymes, Chromatin organization, Cushing syndrome - Mus musculus (mouse), Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of gene expression, Epigenetic regulation of gene expression by MLL3 and MLL4 complexes, Formation of WDR5-containing histone-modifying complexes, Formation of the beta-catenin:TCF transactivating complex, Gene expression (Transcription), Generic Transcription Pathway, PKMTs methylate histone lysines, RNA Polymerase II Transcription, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function, Signal Transduction, Signaling by WNT, TCF dependent signaling in response to WNT, Transcriptional regulation by RUNX1
UniProt: Q91X20
Entrez ID: 23808
|
Does Knockout of G3bp1 in Melanoma Cell Line causally result in tumorigenicity?
| 0
| 615
|
Knockout
|
G3bp1
|
tumorigenicity
|
Melanoma Cell Line
|
Gene: G3bp1 (G3BP stress granule assembly factor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: defense response to virus, immune system process, innate immune response, negative regulation of canonical Wnt signaling pathway, positive regulation of type I interferon production, stress granule assembly; MF: ATP binding, ATP hydrolysis activity, DNA binding, DNA helicase activity, DNA/RNA helicase activity, RNA binding, RNA helicase activity, endonuclease activity, helicase activity, hydrolase activity, mRNA binding, molecular condensate scaffold activity, nuclease activity, nucleic acid binding, nucleotide binding, protein binding, ribosomal small subunit binding; CC: cytoplasm, cytoplasmic stress granule, cytosol, nucleus, perikaryon
Pathways:
UniProt: P97855
Entrez ID: 27041
|
Does Knockout of Fzd6 in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Fzd6
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Fzd6 (frizzled class receptor 6)
Type: protein-coding
Summary: Enables Wnt-protein binding activity. Acts upstream of or within several processes, including cell proliferation in midbrain; embryonic morphogenesis; and establishment of body hair planar orientation. Located in apical plasma membrane; apicolateral plasma membrane; and endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in nonsyndromic congenital nail disorder 1. Orthologous to human FZD6 (frizzled class receptor 6). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: G protein-coupled receptor signaling pathway, Wnt signaling pathway, Wnt signaling pathway, planar cell polarity pathway, canonical Wnt signaling pathway, cell proliferation in midbrain, cell surface receptor signaling pathway, embryonic nail plate morphogenesis, establishment of body hair planar orientation, establishment of planar polarity, hair follicle development, inner ear morphogenesis, midbrain development, negative regulation of canonical Wnt signaling pathway, negative regulation of transcription by RNA polymerase II, nervous system development, neural tube closure, non-canonical Wnt signaling pathway, platelet activation, signal transduction; MF: G protein-coupled receptor activity, Wnt receptor activity, Wnt-protein binding, protein binding, transmembrane signaling receptor activity, ubiquitin protein ligase binding; CC: apical part of cell, apical plasma membrane, apicolateral plasma membrane, cell surface, ciliary basal body, cilium, cytoplasmic vesicle, cytoplasmic vesicle membrane, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, plasma membrane
Pathways: Alzheimer disease - Mus musculus (mouse), Basal cell carcinoma - Mus musculus (mouse), Beta-catenin independent WNT signaling, Breast cancer - Mus musculus (mouse), Ca2+ pathway, Cushing syndrome - Mus musculus (mouse), Gastric cancer - Mus musculus (mouse), Hepatocellular carcinoma - Mus musculus (mouse), Hippo signaling pathway - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Melanogenesis - Mus musculus (mouse), PCP/CE pathway, Pathways in cancer - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Proteoglycans in cancer - Mus musculus (mouse), Regulation of FZD by ubiquitination, Signal Transduction, Signaling by WNT, Signaling pathways regulating pluripotency of stem cells - Mus musculus (mouse), TCF dependent signaling in response to WNT, Wnt signaling pathway - Mus musculus (mouse), mTOR signaling pathway - Mus musculus (mouse)
UniProt: Q61089
Entrez ID: 14368
|
Does Knockout of Muc2 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,174
|
Knockout
|
Muc2
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Muc2 (mucin 2)
Type: protein-coding
Summary: An extracellular matrix structural constituent. Involved in host-mediated regulation of intestinal microbiota composition; maintenance of gastrointestinal epithelium; and mucus secretion. Acts upstream of or within several processes, including epithelial cell development; negative regulation of cell migration; and positive regulation of apoptotic process. Located in extracellular matrix; inner mucus layer; and outer mucus layer. Is active in mucus layer. Is expressed in hindgut epithelium and intestine. Used to study inflammatory bowel disease. Human ortholog(s) of this gene implicated in asthma. Orthologous to human MUC2 (mucin 2, oligomeric mucus/gel-forming). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: apoptotic process, detoxification of copper ion, epithelial cell development, host-mediated modulation of intestinal microbiota composition, maintenance of gastrointestinal epithelium, mucus secretion, negative regulation of cell migration, negative regulation of cell population proliferation, positive regulation of apoptotic process; MF: cupric ion binding, cuprous ion binding, extracellular matrix structural constituent, identical protein binding, metal ion binding, protein binding; CC: extracellular matrix, extracellular region, extracellular space, inner mucus layer, mucus layer, outer mucus layer
Pathways: Amoebiasis - Mus musculus (mouse), Gastric cancer - Mus musculus (mouse)
UniProt:
Entrez ID: 17831
|
Does Knockout of Pcdha8 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
Pcdha8
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Pcdha8 (protocadherin alpha 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, heart development, homophilic cell adhesion via plasma membrane adhesion molecules; MF: calcium ion binding, cell adhesion molecule binding, molecular_function; CC: membrane, plasma membrane
Pathways:
UniProt: Q91Y12
Entrez ID: 353235
|
Does Knockout of Anapc10 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Anapc10
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Anapc10 (anaphase promoting complex subunit 10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: anaphase-promoting complex-dependent catabolic process, cell division, protein K11-linked ubiquitination, protein K48-linked ubiquitination, protein branched polyubiquitination, protein ubiquitination; CC: anaphase-promoting complex, cytoplasm
Pathways: APC-Cdc20 mediated degradation of Nek2A, APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Cyclin B, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Assembly of the pre-replicative complex, Autodegradation of Cdh1 by Cdh1:APC/C, CDK-mediated phosphorylation and removal of Cdc6, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle - Mus musculus (mouse), Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, Class I MHC mediated antigen processing & presentation, Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, DNA Replication, DNA Replication Pre-Initiation, Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Immune System, Inactivation of APC/C via direct inhibition of the APC/C complex, Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Spindle Checkpoint, Oocyte meiosis - Mus musculus (mouse), Phosphorylation of the APC/C, Progesterone-mediated oocyte maturation - Mus musculus (mouse), Regulation of APC/C activators between G1/S and early anaphase, Regulation of mitotic cell cycle, S Phase, Senescence-Associated Secretory Phenotype (SASP), Separation of Sister Chromatids, Switching of origins to a post-replicative state, Synthesis of DNA, Targeted protein degradation, Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: Q8K2H6
Entrez ID: 68999
|
Does Knockout of Dld in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Dld
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Dld (dihydrolipoamide dehydrogenase)
Type: protein-coding
Summary: This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In homodimeric form, the encoded protein functions as a dehydrogenase and is found in several multi-enzyme complexes that regulate energy metabolism. However, as a monomer, this protein can function as a protease. [provided by RefSeq, Jan 2014].
Gene Ontology: BP: 2-oxoglutarate decarboxylation to succinyl-CoA, 2-oxoglutarate metabolic process, branched-chain alpha-keto acid decarboxylation to branched-chain acyl-CoA, branched-chain amino acid catabolic process, dihydrolipoamide metabolic process, gastrulation, lipoate metabolic process, mitochondrial electron transport, NADH to ubiquinone, proteolysis, pyruvate decarboxylation to acetyl-CoA, pyruvate metabolic process, regulation of membrane potential, sperm capacitation, tricarboxylic acid cycle; MF: NAD binding, dihydrolipoyl dehydrogenase (NADH) activity, flavin adenine dinucleotide binding, lipoamide binding, oxidoreductase activity, oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor, protein binding; CC: acrosomal matrix, acrosomal vesicle, branched-chain alpha-ketoacid dehydrogenase complex, cell projection, cilium, cytoplasm, cytoplasmic vesicle, mitochondrial matrix, mitochondrion, motile cilium, myelin sheath, nucleus, oxoadipate dehydrogenase complex, oxoglutarate dehydrogenase complex, pyruvate dehydrogenase complex
Pathways: 2-ketoglutarate dehydrogenase complex, Aerobic respiration and respiratory electron transport, BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV, Branched-chain amino acid catabolism, Citrate cycle (TCA cycle) - Mus musculus (mouse), Citric acid cycle (TCA cycle), Glycine degradation, Glycine, serine and threonine metabolism - Mus musculus (mouse), Glycolysis / Gluconeogenesis - Mus musculus (mouse), Glyoxylate and dicarboxylate metabolism - Mus musculus (mouse), Glyoxylate metabolism and glycine degradation, Leucine Catabolism, Lysine catabolism, Lysine degradation - Mus musculus (mouse), Metabolism, Metabolism of amino acids and derivatives, Metabolism of proteins, Mitochondrial protein degradation, OADH complex synthesizes glutaryl-CoA from 2-OA, OGDH complex synthesizes succinyl-CoA from 2-OG, PDH complex synthesizes acetyl-CoA from PYR, Propanoate metabolism - Mus musculus (mouse), Pyruvate metabolism, Pyruvate metabolism - Mus musculus (mouse), Regulation of pyruvate dehydrogenase (PDH) complex, Regulation of pyruvate metabolism, Serine degradation II, Signal Transduction, Signaling by Nuclear Receptors, Signaling by Retinoic Acid, Tryptophan metabolism - Mus musculus (mouse), Valine, leucine and isoleucine degradation - Mus musculus (mouse), acetyl-CoA biosynthesis (from pyruvate), branched-chain α-keto acid dehydrogenase complex, glycine cleavage complex, superpathway of acetyl-CoA biosynthesis
UniProt: O08749
Entrez ID: 13382
|
Does Knockout of Vmn1r198 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 161
|
Knockout
|
Vmn1r198
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Vmn1r198 (vomeronasal 1 receptor 198)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled receptor activity, pheromone binding, pheromone receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: A0A2I3BR45, Q8R263
Entrez ID: 171254
|
Does Knockout of Vcan in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Vcan
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Vcan (versican)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, central nervous system development, glial cell migration, heart development, skeletal system development, system development, ureteric bud development; MF: calcium ion binding, carbohydrate binding, extracellular matrix structural constituent conferring compression resistance, hyaluronic acid binding, protein phosphatase binding; CC: cell projection, cell surface, extracellular matrix, extracellular region, extracellular space, interphotoreceptor matrix, perineuronal net, photoreceptor outer segment, synapse
Pathways: Cell adhesion molecules - Mus musculus (mouse)
UniProt: E9QMK2, Q8BS97, E9QMK3, E9PYH0, G3XA35, F7B603, F7B6F7, E0CZC0
Entrez ID: 13003
|
Does Knockout of Atxn7l2 in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Atxn7l2
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Atxn7l2 (ataxin 7-like 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: B7ZCC3, Q8C8K6, B7ZCC4, A2AE44
Entrez ID: 72522
|
Does Knockout of Psen2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
Psen2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Psen2 (presenilin 2)
Type: protein-coding
Summary: This gene encodes a member of the presenilin family. Presenilins are catalytic components of the multi-subunit gamma-secretase complex, which mediates critical cellular processes through cleavage of type I transmembrane proteins including Notch receptors and the amyloid precursor protein. The encoded protein contains eight transmembrane domains and is localized to the endoplasmic reticulum, where it may play a role in calcium homeostasis. Following assembly of the gamma-secretase complex, the encoded protein is cleaved into N- and C-terminal fragments and the activated complex is released from the endoplasmic reticulum. Inactivation of this gene results in impaired synaptic function in a mouse model for Alzheimer's disease. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Apr 2011].
Gene Ontology: BP: Notch signaling pathway, T cell activation involved in immune response, T cell receptor signaling pathway, amyloid precursor protein catabolic process, amyloid-beta formation, amyloid-beta metabolic process, brain morphogenesis, calcium ion homeostasis, calcium ion transport, cardiac muscle contraction, cell fate specification, dorsal/ventral neural tube patterning, embryonic limb morphogenesis, endoplasmic reticulum calcium ion homeostasis, forebrain development, hair follicle development, hematopoietic progenitor cell differentiation, intracellular signal transduction, learning or memory, locomotion, lung alveolus development, membrane protein ectodomain proteolysis, memory, mitochondrion-endoplasmic reticulum membrane tethering, myeloid leukocyte differentiation, negative regulation of apoptotic signaling pathway, negative regulation of epidermal growth factor receptor signaling pathway, negative regulation of protein-containing complex assembly, negative regulation of transcription by RNA polymerase II, negative regulation of ubiquitin-dependent protein catabolic process, neuroinflammatory response, neuron cellular homeostasis, positive regulation of apoptotic process, positive regulation of coagulation, positive regulation of extrinsic apoptotic signaling pathway via death domain receptors, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of receptor recycling, protein catabolic process at postsynapse, protein maturation, protein processing, protein transport, proteolysis, regulation of calcium import into the mitochondrion, regulation of postsynapse organization, regulation of synaptic plasticity, skin morphogenesis, somitogenesis, thymus development; MF: aspartic endopeptidase activity, intramembrane cleaving, endopeptidase activity, hydrolase activity, peptidase activity, protein binding; CC: Golgi apparatus, Golgi membrane, Z disc, centrosome, ciliary basal body, cytosol, early endosome, endomembrane system, endoplasmic reticulum, endoplasmic reticulum membrane, gamma-secretase complex, glutamatergic synapse, kinetochore, membrane, neuronal cell body, nuclear inner membrane, plasma membrane, postsynapse, presynaptic membrane, protein-containing complex, synaptic membrane, synaptic vesicle
Pathways: Alzheimer disease - Mus musculus (mouse), Axon guidance, Cell death signalling via NRAGE, NRIF and NADE, Death Receptor Signaling, Developmental Biology, EPH-Ephrin signaling, EPH-ephrin mediated repulsion of cells, NOTCH3 Activation and Transmission of Signal to the Nucleus, NRIF signals cell death from the nucleus, Nervous system development, Neurotrophin signaling pathway - Mus musculus (mouse), Noncanonical activation of NOTCH3, Notch signaling pathway - Mus musculus (mouse), Nuclear signaling by ERBB4, Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Regulated proteolysis of p75NTR, Signal Transduction, Signaling by ERBB4, Signaling by NOTCH, Signaling by NOTCH3, Signaling by Receptor Tyrosine Kinases, Signaling by TGFB family members, Signaling by TGFBR3, TGFBR3 PTM regulation, p75 NTR receptor-mediated signalling
UniProt: Q61144
Entrez ID: 19165
|
Does Knockout of Nudt21 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Nudt21
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Nudt21 (nudix hydrolase 21)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway, mRNA 3'-end processing, mRNA alternative polyadenylation, mRNA processing, positive regulation of pro-B cell differentiation, positive regulation of stem cell differentiation, post-transcriptional regulation of gene expression, protein heterotetramerization, protein tetramerization; MF: RNA binding, chromatin binding, histone deacetylase binding, identical protein binding, mRNA 3'-UTR AU-rich region binding, mRNA binding, protein binding, protein homodimerization activity; CC: centriolar satellite, centrosome, cytoplasm, mRNA cleavage and polyadenylation specificity factor complex, mRNA cleavage factor complex, nuclear body, nucleus, paraspeckles
Pathways: Gene expression (Transcription), Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Processing of Capped Intronless Pre-mRNA, Processing of Intronless Pre-mRNAs, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, mRNA 3'-end processing, mRNA surveillance pathway - Mus musculus (mouse)
UniProt: Q9CQF3
Entrez ID: 68219
|
Does Knockout of Kmt5b in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Kmt5b
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Kmt5b (lysine methyltransferase 5B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA repair, chromatin organization, chromatin remodeling, methylation, muscle organ development, positive regulation of double-strand break repair via nonhomologous end joining, positive regulation of isotype switching; MF: S-adenosyl-L-methionine binding, chromatin binding, histone H4K20 methyltransferase activity, histone H4K20 monomethyltransferase activity, histone H4K20me methyltransferase activity, histone methyltransferase activity, metal ion binding, methyltransferase activity, transferase activity; CC: centrosome, chromosome, ciliary basal body, cilium, condensed chromosome, centromeric region, cytoplasmic ribonucleoprotein granule, fibrillar center, intercellular bridge, microtubule cytoskeleton, mitotic spindle, nucleolus, nucleoplasm, nucleus, plasma membrane
Pathways: Chromatin modifying enzymes, Chromatin organization, Lysine degradation - Mus musculus (mouse), PKMTs methylate histone lysines
UniProt: Q3U8K7
Entrez ID: 225888
|
Does Knockout of Phospho1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Phospho1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Phospho1 (phosphatase, orphan 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: bone mineralization, bone mineralization involved in bone maturation, endochondral ossification, regulation of bone mineralization; MF: hydrolase activity, metal ion binding, phosphatase activity, phosphocholine phosphatase activity, phosphoethanolamine phosphatase activity, pyrophosphatase activity; CC: extracellular matrix, extracellular membrane-bounded organelle
Pathways: Glycerophospholipid biosynthesis, Glycerophospholipid metabolism - Mus musculus (mouse), Metabolism, Metabolism of lipids, Phospholipid metabolism, Synthesis of PC, Synthesis of PE
UniProt: Q8R2H9
Entrez ID: 237928
|
Does Knockout of Slf1 in Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,528
|
Knockout
|
Slf1
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Slf1 (SMC5-SMC6 complex localization factor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, positive regulation of double-strand break repair, positive regulation of maintenance of mitotic sister chromatid cohesion, positive regulation of protein-containing complex assembly, protein localization to site of double-strand break; MF: protein binding, protein-containing complex binding, ubiquitin protein ligase binding; CC: centrosome, chromosome, cytoplasm, cytoskeleton, nuclear inclusion body, nucleoplasm, nucleosome, nucleus, site of double-strand break
Pathways:
UniProt: Q8R3P9
Entrez ID: 105377
|
Does Knockout of Ern2 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Ern2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Ern2 (endoplasmic reticulum to nucleus signalling 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: IRE1-mediated unfolded protein response, apoptotic chromosome condensation, apoptotic process, endoplasmic reticulum unfolded protein response, intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress, mRNA processing, negative regulation of DNA-templated transcription, positive regulation of JNK cascade, protein phosphorylation, rRNA catabolic process, regulation of DNA-templated transcription, response to endoplasmic reticulum stress, response to unfolded protein; MF: ATP binding, RNA endonuclease activity, RNA nuclease activity, catalytic activity, endonuclease activity, hydrolase activity, kinase activity, magnesium ion binding, metal ion binding, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity, unfolded protein binding; CC: IRE1-TRAF2-ASK1 complex, cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum quality control compartment, membrane
Pathways:
UniProt: Q9Z2E3
Entrez ID: 26918
|
Does Knockout of Hsd17b12 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,262
|
Knockout
|
Hsd17b12
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Hsd17b12 (hydroxysteroid (17-beta) dehydrogenase 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: estrogen biosynthetic process, extracellular matrix organization, fatty acid biosynthetic process, fatty acid elongation, saturated fatty acid, lipid metabolic process, positive regulation of cell-substrate adhesion, steroid biosynthetic process; MF: collagen binding, estradiol 17-beta-dehydrogenase [NAD(P)+] activity, fibronectin binding, heparin binding, oxidoreductase activity, very-long-chain 3-oxoacyl-CoA reductase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, extracellular matrix, fatty acid elongase complex, membrane
Pathways: Androgen biosynthesis, Biosynthesis of unsaturated fatty acids - Mus musculus (mouse), Fatty acid elongation - Mus musculus (mouse), Fatty acid metabolism, Fatty acyl-CoA biosynthesis, Metabolism, Metabolism of lipids, Metabolism of steroid hormones, Metabolism of steroids, Steroid hormone biosynthesis - Mus musculus (mouse), Synthesis of very long-chain fatty acyl-CoAs, biosynthesis of estrogens
UniProt: O70503
Entrez ID: 56348
|
Does Knockout of Gpam in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,273
|
Knockout
|
Gpam
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Gpam (glycerol-3-phosphate acyltransferase, mitochondrial)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CDP-diacylglycerol biosynthetic process, acyl-CoA metabolic process, cellular response to insulin stimulus, defense response to virus, diacylglycerol biosynthetic process, fatty acid homeostasis, fatty acid metabolic process, glycerophospholipid metabolic process, lipid metabolic process, negative regulation of activation-induced cell death of T cells, phosphatidic acid biosynthetic process, phosphatidylglycerol biosynthetic process, phospholipid biosynthetic process, phospholipid homeostasis, positive regulation of activated T cell proliferation, positive regulation of multicellular organism growth, positive regulation of triglyceride biosynthetic process, regulation of cytokine production, response to activity, response to glucose, triglyceride biosynthetic process, triglyceride metabolic process; MF: O-acyltransferase activity, acyltransferase activity, glycerol-3-phosphate O-acyltransferase activity, transferase activity; CC: endoplasmic reticulum membrane, membrane, mitochondrial inner membrane, mitochondrial membrane, mitochondrial outer membrane, mitochondrion, plasma membrane
Pathways: CDP-diacylglycerol biosynthesis I, CDP-diacylglycerol biosynthesis II, Glycerolipid metabolism - Mus musculus (mouse), Glycerophospholipid biosynthesis, Glycerophospholipid metabolism - Mus musculus (mouse), Metabolism, Metabolism of lipids, Phospholipid metabolism, Synthesis of PA, Triglyceride biosynthesis, Triglyceride metabolism, phosphatidylglycerol biosynthesis I (plastidic), phosphatidylglycerol biosynthesis II (non-plastidic), phospholipid biosynthesis I, triacylglycerol biosynthesis
UniProt: Q61586
Entrez ID: 14732
|
Does Knockout of Asb1 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Asb1
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Asb1 (ankyrin repeat and SOCS box-containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intracellular signal transduction, male genitalia development, proteasome-mediated ubiquitin-dependent protein catabolic process, protein ubiquitination; MF: ubiquitin protein ligase activity, ubiquitin-like ligase-substrate adaptor activity; CC: ubiquitin ligase complex
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System, Metabolism of proteins, Neddylation, Post-translational protein modification
UniProt: Q9WV74
Entrez ID: 65247
|
Does Knockout of Kmt2a in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Kmt2a
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Kmt2a (lysine (K)-specific methyltransferase 2A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T-helper 2 cell differentiation, anterior/posterior pattern specification, cellular response to transforming growth factor beta stimulus, chromatin organization, circadian regulation of gene expression, cognition, definitive hemopoiesis, embryonic hemopoiesis, epigenetic regulation of gene expression, exploration behavior, homeostasis of number of cells within a tissue, immune system process, membrane depolarization, methylation, negative regulation of DNA methylation-dependent heterochromatin formation, negative regulation of fibroblast proliferation, positive regulation of DNA-templated transcription, positive regulation of gene expression, positive regulation of transcription by RNA polymerase II, post-embryonic development, protein-containing complex assembly, regulation of DNA-templated transcription, regulation of gene expression, regulation of short-term neuronal synaptic plasticity, response to light stimulus, response to potassium ion, rhythmic process, spleen development, transcription initiation-coupled chromatin remodeling, visual learning; MF: DNA binding, DNA-binding transcription factor binding, chromatin binding, histone H3K4 methyltransferase activity, histone H3K4 monomethyltransferase activity, histone H3K4 trimethyltransferase activity, identical protein binding, metal ion binding, methyltransferase activity, protein binding, protein homodimerization activity, protein-cysteine methyltransferase activity, transferase activity, unmethylated CpG binding, zinc ion binding; CC: MLL1 complex, cytosol, histone methyltransferase complex, nucleoplasm, nucleus
Pathways: Cushing syndrome - Mus musculus (mouse), Lysine degradation - Mus musculus (mouse), Transcriptional misregulation in cancer - Mus musculus (mouse)
UniProt:
Entrez ID: 214162
|
Does Knockout of N6amt1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 2,176
|
Knockout
|
N6amt1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: N6amt1 (N-6 adenine-specific DNA methyltransferase 1 (putative))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: arsonoacetate metabolic process, chromatin organization, methylation, negative regulation of gene expression, epigenetic, peptidyl-glutamine methylation, positive regulation of cell growth, toxin metabolic process, transcription initiation-coupled chromatin remodeling; MF: S-adenosyl-L-methionine binding, S-adenosylmethionine-dependent methyltransferase activity, arsenite methyltransferase activity, histone H4K12 methyltransferase activity, histone methyltransferase activity, methyltransferase activity, nucleic acid binding, protein binding, protein methyltransferase activity, protein-glutamine N-methyltransferase activity, site-specific DNA-methyltransferase (adenine-specific) activity, transferase activity; CC: eRF1 methyltransferase complex, nucleus, protein-containing complex
Pathways: Biological oxidations, Eukaryotic Translation Termination, Metabolism, Metabolism of proteins, Methylation, Phase II - Conjugation of compounds, Translation
UniProt: Q6SKR2
Entrez ID: 67768
|
Does Knockout of Pard6a in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 165
|
Knockout
|
Pard6a
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Pard6a (par-6 family cell polarity regulator alpha)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, cell-cell junction maintenance, centrosome cycle, establishment of cell polarity, establishment or maintenance of cell polarity, establishment or maintenance of epithelial cell apical/basal polarity, positive regulation of protein localization to centrosome, positive regulation of protein secretion, regulation of cellular localization; MF: GTP-dependent protein binding, protein binding, protein-macromolecule adaptor activity, small GTPase binding; CC: PAR polarity complex, anchoring junction, apical plasma membrane, axonal growth cone, bicellular tight junction, cell cortex, cell junction, centriolar satellite, centrosome, cytoplasm, cytoskeleton, membrane, neuronal cell body, nucleus, plasma membrane, protein-containing complex
Pathways: Asymmetric localization of PCP proteins, Axon guidance - Mus musculus (mouse), Beta-catenin independent WNT signaling, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Endocytosis - Mus musculus (mouse), Hippo signaling pathway - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), PCP/CE pathway, RAC1 GTPase cycle, RHO GTPase cycle, RHOU GTPase cycle, RHOV GTPase cycle, Rap1 signaling pathway - Mus musculus (mouse), Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by TGF-beta Receptor Complex, Signaling by TGFB family members, Signaling by WNT, TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition), Tight junction - Mus musculus (mouse), Tight junction interactions
UniProt: Q9Z101
Entrez ID: 56513
|
Does Knockout of Ccdc126 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Ccdc126
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Ccdc126 (coiled-coil domain containing 126)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q8BIS8
Entrez ID: 57895
|
Does Knockout of Ldb1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Ldb1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Ldb1 (LIM domain binding 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Wnt signaling pathway, anterior/posterior axis specification, cerebellar Purkinje cell differentiation, cerebellum development, epithelial structure maintenance, gastrulation with mouth forming second, hair follicle development, head development, negative regulation of DNA-templated transcription, negative regulation of erythrocyte differentiation, negative regulation of transcription by RNA polymerase II, nervous system development, neuron differentiation, positive regulation of cell adhesion, positive regulation of hemoglobin biosynthetic process, positive regulation of transcription by RNA polymerase II, positive regulation of transcription elongation by RNA polymerase II, primitive erythrocyte differentiation, regulation of cell migration, regulation of focal adhesion assembly, regulation of kinase activity, somatic stem cell population maintenance, transcription by RNA polymerase II, transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery; MF: DNA binding, DNA-binding transcription factor binding, LIM domain binding, RNA polymerase II-specific DNA-binding transcription factor binding, chromatin binding, enzyme binding, identical protein binding, protein binding, protein homodimerization activity, transcription coactivator activity, transcription coregulator activity; CC: RNA polymerase II transcription regulator complex, beta-catenin-TCF complex, cell leading edge, chromatin, nucleoplasm, nucleus, protein-containing complex, transcription regulator complex
Pathways: Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Transcriptional misregulation in cancer - Mus musculus (mouse), Transcriptional regulation by RUNX1
UniProt: P70662
Entrez ID: 16825
|
Does Knockout of Lztfl1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 161
|
Knockout
|
Lztfl1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Lztfl1 (leucine zipper transcription factor-like 1)
Type: protein-coding
Summary: Predicted to enable identical protein binding activity. Acts upstream of or within flagellated sperm motility and spermatogenesis. Located in cilium; cytoplasm; and manchette. Is expressed in several structures, including brain; sensory organ; testis; and upper jaw incisor. Used to study Bardet-Biedl syndrome 17. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome 17. Orthologous to human LZTFL1 (leucine zipper transcription factor like 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: flagellated sperm motility, negative regulation of protein localization to ciliary membrane, negative regulation of protein localization to cilium, spermatogenesis; MF: identical protein binding, protein binding, protein-containing complex binding; CC: cilium, cytoplasm, cytosol, manchette
Pathways: BBSome-mediated cargo-targeting to cilium, Cargo trafficking to the periciliary membrane, Cilium Assembly, Organelle biogenesis and maintenance
UniProt: Q9JHQ5
Entrez ID: 93730
|
Does Knockout of Klk8 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 1
| 1,133
|
Knockout
|
Klk8
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Klk8 (kallikrein related-peptidase 8)
Type: protein-coding
Summary: This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded preproprotein undergoes proteolytic cleavage of the activation peptide to generate the functional enzyme. Mice lacking the encoded protein exhibit impaired long-term potentiation and increased anxiety, as well as a hyperkeratosis phenotype. This gene is located in a cluster of several related kallikrein genes on chromosome 7. [provided by RefSeq, May 2016].
Gene Ontology: BP: ERBB4 signaling pathway, keratinocyte proliferation, memory, neuron projection morphogenesis, protein maturation, proteolysis, regulation of synapse organization, response to wounding, synapse organization; MF: hydrolase activity, peptidase activity, serine-type endopeptidase activity, serine-type peptidase activity; CC: cytoplasm, extracellular region, extracellular space, secretory granule, serine protease inhibitor complex
Pathways: Developmental Biology, Formation of the cornified envelope, Keratinization
UniProt: Q61955
Entrez ID: 259277
|
Does Knockout of Ppa1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Ppa1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Ppa1 (pyrophosphatase (inorganic) 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: phosphate-containing compound metabolic process; MF: hydrolase activity, inorganic diphosphate phosphatase activity, magnesium ion binding, metal ion binding, pyrophosphatase activity
Pathways: Cytosolic tRNA aminoacylation, Metabolism, Metabolism of proteins, Oxidative phosphorylation - Mus musculus (mouse), Pyrophosphate hydrolysis, Translation, tRNA Aminoacylation
UniProt: Q9D819
Entrez ID: 67895
|
Does Knockout of Supt3 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Supt3
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Supt3 (SPT3, SAGA and STAGA complex component)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, transcription by RNA polymerase II; MF: protein heterodimerization activity, transcription coactivator activity; CC: SAGA complex, nucleoplasm, nucleus, transcription factor TFTC complex
Pathways: Transcriptional misregulation in cancer - Mus musculus (mouse)
UniProt: B0QZW4, Q8BVY4, B0QZW5
Entrez ID: 109115
|
Does Knockout of Etnk2 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 165
|
Knockout
|
Etnk2
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Etnk2 (ethanolamine kinase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: glycerophospholipid biosynthetic process, in utero embryonic development, lipid metabolic process, multicellular organism growth, phosphatidylethanolamine biosynthetic process, phospholipid biosynthetic process, phosphorylation, placenta development, post-embryonic development; MF: ATP binding, choline kinase activity, ethanolamine kinase activity, kinase activity, nucleotide binding, transferase activity
Pathways: Glycerophospholipid biosynthesis, Glycerophospholipid metabolism - Mus musculus (mouse), Metabolism, Metabolism of lipids, Phospholipid metabolism, Synthesis of PE, phosphatidylethanolamine biosynthesis II
UniProt: A7MCT6
Entrez ID: 214253
|
Does Knockout of Arih1 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,265
|
Knockout
|
Arih1
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Arih1 (ariadne RBR E3 ubiquitin protein ligase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein ubiquitination, ubiquitin-dependent protein catabolic process; MF: metal ion binding, transferase activity, ubiquitin conjugating enzyme binding, ubiquitin protein ligase activity, ubiquitin protein ligase binding, ubiquitin-protein transferase activity, zinc ion binding; CC: Cajal body, Cul2-RING ubiquitin ligase complex, Cul3-RING ubiquitin ligase complex, Cul4A-RING E3 ubiquitin ligase complex, Lewy body, SCF ubiquitin ligase complex, cytoplasm, nuclear body, nucleoplasm, nucleus, ubiquitin ligase complex
Pathways: Antiviral mechanism by IFN-stimulated genes, Cytokine Signaling in Immune system, ISG15 antiviral mechanism, Immune System, Interferon Signaling, Modulation of host responses by IFN-stimulated genes, PKR-mediated signaling
UniProt: Q9Z1K5
Entrez ID: 23806
|
Does Knockout of Zdhhc2 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,171
|
Knockout
|
Zdhhc2
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Zdhhc2 (zinc finger, DHHC domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: peptidyl-L-cysteine S-palmitoylation, positive regulation of AMPA glutamate receptor clustering, positive regulation of endosome to plasma membrane protein transport, positive regulation of long-term synaptic potentiation, postsynaptic neurotransmitter receptor cycle, protein localization to membrane raft, protein localization to plasma membrane, protein localization to postsynaptic membrane, protein targeting to membrane, regulation of cell-cell adhesion, regulation of neuronal synaptic plasticity, regulation of postsynaptic neurotransmitter receptor diffusion trapping, regulation of protein catabolic process, regulation of protein localization to plasma membrane, synapse assembly, synaptic vesicle maturation; MF: acyltransferase activity, palmitoyltransferase activity, protein homodimerization activity, protein-cysteine S-myristoyltransferase activity, protein-cysteine S-palmitoyltransferase activity, protein-cysteine S-stearoyltransferase activity, transferase activity; CC: Golgi apparatus, Golgi membrane, endoplasmic reticulum, endoplasmic reticulum membrane, endosome, glutamatergic synapse, membrane, plasma membrane, postsynaptic density, postsynaptic recycling endosome, postsynaptic recycling endosome membrane, recycling endosome membrane, synapse
Pathways: Metabolism of proteins, Surfactant metabolism
UniProt: P59267
Entrez ID: 70546
|
Does Knockout of Zfp868 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Zfp868
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Zfp868 (zinc finger protein 868)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Mus musculus (mouse), RNA Polymerase II Transcription
UniProt: Q3UTQ6
Entrez ID: 234362
|
Does Knockout of Mettl3 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,262
|
Knockout
|
Mettl3
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Mettl3 (methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, RNA methylation, cell differentiation, cellular response to UV, circadian rhythm, dosage compensation by inactivation of X chromosome, endothelial to hematopoietic transition, forebrain radial glial cell differentiation, gliogenesis, immune system process, innate immune response, mRNA catabolic process, mRNA destabilization, mRNA export from nucleus, mRNA modification, mRNA processing, mRNA splicing, via spliceosome, methylation, negative regulation of Notch signaling pathway, negative regulation of type I interferon-mediated signaling pathway, oogenesis, positive regulation of cap-independent translational initiation, positive regulation of mRNA catabolic process, positive regulation of translation, primary miRNA processing, regulation of T cell differentiation, regulation of hematopoietic stem cell differentiation, regulation of meiotic cell cycle, rhythmic process, spermatogenesis, stem cell population maintenance; MF: RNA binding, RNA methyltransferase activity, S-adenosyl-L-methionine binding, mRNA binding, mRNA m(6)A methyltransferase activity, methyltransferase activity, protein binding, protein heterodimerization activity, transferase activity; CC: Golgi apparatus, RNA N6-methyladenosine methyltransferase complex, cytoplasm, cytosol, nuclear body, nuclear speck, nucleoplasm, nucleus
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA
UniProt: Q8C3P7
Entrez ID: 56335
|
Does Knockout of Thnsl1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Thnsl1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Thnsl1 (threonine synthase-like 1 (bacterial))
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q8BH55
Entrez ID: 208967
|
Does Knockout of Zfp358 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Zfp358
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Zfp358 (zinc finger protein 358)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: nucleus
Pathways:
UniProt: A0A140LJC3, E9Q8M1
Entrez ID: 140482
|
Does Knockout of Cand1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,264
|
Knockout
|
Cand1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Cand1 (cullin associated and neddylation disassociated 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: SCF complex assembly, cell differentiation, negative regulation of catalytic activity, positive regulation of DNA-templated transcription, positive regulation of RNA polymerase II transcription preinitiation complex assembly, protein ubiquitination; MF: TBP-class protein binding, protein binding; CC: Golgi apparatus, cullin-RING ubiquitin ligase complex, cytoplasm, cytosol, nucleoplasm, nucleus, ubiquitin ligase complex
Pathways: Immune System, Innate Immune System, Iron uptake and transport, Metabolism of proteins, Neddylation, Neutrophil degranulation, Post-translational protein modification, Transport of small molecules
UniProt: Q6ZQ38
Entrez ID: 71902
|
Does Knockout of Mblac2 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Mblac2
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Mblac2 (metallo-beta-lactamase domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, fatty acid metabolic process, lipid metabolic process; MF: beta-lactamase activity, hydrolase activity, long-chain fatty acyl-CoA hydrolase activity, metal ion binding, molecular_function; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, plasma membrane
Pathways:
UniProt: Q8BL86
Entrez ID: 72852
|
Does Knockout of Rabep1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Rabep1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Rabep1 (rabaptin, RAB GTPase binding effector protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi to plasma membrane transport, apoptotic process, endocytosis, protein localization to ciliary membrane, protein transport, regulation of postsynaptic neurotransmitter receptor internalization, signal transduction, vesicle-mediated transport; MF: GTPase activator activity, growth factor activity, protein binding, protein domain specific binding, protein homodimerization activity; CC: cytoplasm, cytoplasmic vesicle, cytosol, early endosome, endocytic vesicle, endosome, glutamatergic synapse, presynaptic cytosol, protein-containing complex, recycling endosome
Pathways: Endocytosis - Mus musculus (mouse)
UniProt: O35551
Entrez ID: 54189
|
Does Knockout of Mpnd in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,271
|
Knockout
|
Mpnd
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Mpnd (MPN domain containing)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: double-strand break repair, proteolysis; MF: hydrolase activity, metal ion binding, metallopeptidase activity, peptidase activity, polyubiquitin modification-dependent protein binding; CC: BRCA1-A complex, BRISC complex
Pathways:
UniProt: Q3TV65
Entrez ID: 68047
|
Does Knockout of Dctn5 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Dctn5
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Dctn5 (dynactin 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: aorta development, coronary vasculature development, ventricular septum development; CC: centrosome, chromosome, chromosome, centromeric region, cytoplasm, cytoskeleton, dynactin complex, kinetochore, nuclear membrane, nucleoplasm
Pathways: Adaptive Immune System, Amyotrophic lateral sclerosis - Mus musculus (mouse), Asparagine N-linked glycosylation, COPI-independent Golgi-to-ER retrograde traffic, COPI-mediated anterograde transport, Cellular responses to stimuli, Cellular responses to stress, ER to Golgi Anterograde Transport, Golgi-to-ER retrograde transport, HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand, Huntington disease - Mus musculus (mouse), Immune System, Intra-Golgi and retrograde Golgi-to-ER traffic, MHC class II antigen presentation, Membrane Trafficking, Metabolism of proteins, Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Post-translational protein modification, Salmonella infection - Mus musculus (mouse), Transport to the Golgi and subsequent modification, Vasopressin-regulated water reabsorption - Mus musculus (mouse), Vesicle-mediated transport
UniProt: Q9QZB9
Entrez ID: 59288
|
Does Knockout of Rorc in Embryonic Fibroblast Cell Line causally result in autophagy?
| 1
| 1,043
|
Knockout
|
Rorc
|
autophagy
|
Embryonic Fibroblast Cell Line
|
Gene: Rorc (RAR-related orphan receptor gamma)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Peyer's patch development, T cell differentiation in thymus, T-helper 17 cell differentiation, T-helper cell differentiation, adipose tissue development, alpha-beta T cell differentiation, cell differentiation, cellular response to sterol, circadian regulation of gene expression, intracellular receptor signaling pathway, lymph node development, mucosa-associated lymphoid tissue development, negative regulation of thymocyte apoptotic process, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of circadian rhythm, regulation of DNA-templated transcription, regulation of fat cell differentiation, regulation of gamma-delta T cell differentiation, regulation of gene expression, regulation of glucose metabolic process, regulation of steroid metabolic process, regulation of transcription by RNA polymerase II, regulatory T cell differentiation, rhythmic process, tolerance induction in gut-associated lymphoid tissue, xenobiotic metabolic process; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, ligand-modulated transcription factor activity, metal ion binding, nuclear receptor activity, oxysterol binding, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription coactivator binding, zinc ion binding; CC: external side of plasma membrane, nuclear body, nucleoplasm, nucleus
Pathways: Circadian rhythm - Mus musculus (mouse), Inflammatory bowel disease - Mus musculus (mouse), Th17 cell differentiation - Mus musculus (mouse)
UniProt: P51450
Entrez ID: 19885
|
Does Knockout of Skor2 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Skor2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Skor2 (SKI family transcriptional corepressor 2)
Type: protein-coding
Summary: Enables SMAD binding activity; chromatin binding activity; and histone deacetylase binding activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including cerebellar Purkinje cell differentiation; regulation of neural precursor cell proliferation; and regulation of signal transduction. Located in nucleus. Is expressed in brain; dorsal root ganglion; and spinal cord. Orthologous to human SKOR2 (SKI family transcriptional corepressor 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cell development, cerebellar Purkinje cell differentiation, cerebellum morphogenesis, negative regulation of BMP signaling pathway, negative regulation of transcription by RNA polymerase II, negative regulation of transforming growth factor beta receptor signaling pathway, positive regulation of smoothened signaling pathway, regulation of cerebellar granule cell precursor proliferation, regulation of dendrite morphogenesis, regulation of neuroblast proliferation; MF: DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, SMAD binding, chromatin binding, histone deacetylase binding, sequence-specific double-stranded DNA binding; CC: cytoplasm, nucleus, transcription regulator complex
Pathways:
UniProt: A7M7C7
Entrez ID: 664805
|
Does Knockout of Entpd7 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Entpd7
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Entpd7 (ectonucleoside triphosphate diphosphohydrolase 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CTP catabolic process, CTP metabolic process, GTP metabolic process, T-helper 17 cell differentiation, UDP catabolic process, UTP catabolic process, nucleobase-containing small molecule catabolic process, regulation of immune response, ribonucleoside diphosphate catabolic process, ribonucleoside triphosphate catabolic process; MF: ATP hydrolysis activity, CTPase activity, GDP phosphatase activity, GTPase activity, UDP phosphatase activity, hydrolase activity, metal ion binding, nucleoside diphosphate phosphatase activity, ribonucleoside triphosphate phosphatase activity; CC: Golgi apparatus, cytoplasmic vesicle, cytoplasmic vesicle membrane, membrane, nucleus
Pathways: Metabolism, Metabolism of nucleotides, Nucleotide catabolism, Phosphate bond hydrolysis by NTPDase proteins
UniProt: Q3TCT4
Entrez ID: 93685
|
Does Knockout of Smarca4 in Pancreatic Cell Line causally result in protein/peptide accumulation?
| 1
| 2,198
|
Knockout
|
Smarca4
|
protein/peptide accumulation
|
Pancreatic Cell Line
|
Gene: Smarca4 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: aorta development, aortic smooth muscle cell differentiation, blastocyst growth, blastocyst hatching, blood vessel development, cell morphogenesis, chromatin organization, chromatin remodeling, coronary vasculature development, definitive erythrocyte differentiation, embryonic hindlimb morphogenesis, embryonic organ morphogenesis, epidermis morphogenesis, extracellular matrix organization, forebrain development, gene expression, glial cell fate determination, heart development, heart trabecula formation, heterochromatin formation, hindbrain development, host-mediated activation of viral transcription, in utero embryonic development, keratinocyte differentiation, lens fiber cell development, liver development, negative regulation of DNA-templated transcription, negative regulation of androgen receptor signaling pathway, negative regulation of apoptotic process, negative regulation of cell differentiation, negative regulation of cell growth, negative regulation of transcription by RNA polymerase II, nervous system development, neurogenesis, nucleosome assembly, nucleosome disassembly, outflow tract morphogenesis, pharyngeal arch artery morphogenesis, positive regulation of DNA-templated transcription, positive regulation of T cell differentiation, positive regulation of Wnt signaling pathway, positive regulation of cell differentiation, positive regulation of cell population proliferation, positive regulation of cold-induced thermogenesis, positive regulation of double-strand break repair, positive regulation of glucose mediated signaling pathway, positive regulation of miRNA transcription, positive regulation of myoblast differentiation, positive regulation of signal transduction by p53 class mediator, positive regulation of stem cell population maintenance, positive regulation of transcription by RNA polymerase II, positive regulation of transcription of nucleolar large rRNA by RNA polymerase I, primitive erythrocyte differentiation, regulation of DNA-templated transcription, regulation of G0 to G1 transition, regulation of G1/S transition of mitotic cell cycle, regulation of cell migration, regulation of mitotic metaphase/anaphase transition, regulation of nucleotide-excision repair, regulation of transcription by RNA polymerase II, stem cell population maintenance, transcription initiation-coupled chromatin remodeling, vasculogenesis, ventricular septum development; MF: ATP binding, ATP hydrolysis activity, ATP-dependent activity, acting on DNA, ATP-dependent chromatin remodeler activity, DNA binding, DNA polymerase binding, RNA binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, Tat protein binding, chromatin binding, histone binding, hydrolase activity, identical protein binding, lncRNA binding, nuclear androgen receptor binding, nucleosome array spacer activity, p53 binding, protein binding, protein-containing complex binding, transcription coactivator activity, transcription coregulator binding, transcription corepressor activity; CC: GBAF complex, RSC-type complex, SWI/SNF complex, bBAF complex, chromatin, euchromatin, fibrillar center, kinetochore, male germ cell nucleus, nBAF complex, npBAF complex, nuclear matrix, nucleolus, nucleoplasm, nucleus, perichromatin fibrils
Pathways: ATP-dependent chromatin remodelers, Adherens junctions interactions, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Chromatin modifying enzymes, Chromatin organization, Cytokine Signaling in Immune system, Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF), Formation of the beta-catenin:TCF transactivating complex, Formation of the canonical BAF (cBAF) complex, Formation of the embryonic stem cell BAF (esBAF) complex, Formation of the non-canonical BAF (ncBAF) complex, Formation of the polybromo-BAF (pBAF) complex, Gene expression (Transcription), Generic Transcription Pathway, Hepatocellular carcinoma - Mus musculus (mouse), Immune System, Interleukin-7 signaling, Negative Regulation of CDH1 Gene Transcription, RMTs methylate histone arginines, RNA Polymerase II Transcription, RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known, Regulation of CDH1 Expression and Function, Regulation of CDH1 Gene Transcription, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, SWI/SNF chromatin remodelers, Signal Transduction, Signaling by Interleukins, Signaling by WNT, TCF dependent signaling in response to WNT, Thermogenesis - Mus musculus (mouse), Transcriptional regulation by RUNX1
UniProt: Q3TKT4
Entrez ID: 20586
|
Does Knockout of Ncoa1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Ncoa1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Ncoa1 (nuclear receptor coactivator 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to Thyroglobulin triiodothyronine, cellular response to hormone stimulus, cerebellum development, cerebral cortex development, chromatin remodeling, estrogen receptor signaling pathway, estrous cycle, hippocampus development, hypothalamus development, labyrinthine layer morphogenesis, lactation, mRNA transcription by RNA polymerase II, male gonad development, male mating behavior, peroxisome proliferator activated receptor signaling pathway, positive regulation of DNA-templated transcription, positive regulation of adipose tissue development, positive regulation of apoptotic process, positive regulation of female receptivity, positive regulation of neuron differentiation, positive regulation of transcription by RNA polymerase II, positive regulation of transcription from RNA polymerase II promoter by galactose, progesterone receptor signaling pathway, regulation of DNA-templated transcription, regulation of cellular response to insulin stimulus, regulation of thyroid hormone receptor signaling pathway, response to estradiol, response to hormone, response to progesterone, response to retinoic acid; MF: DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, acyltransferase activity, chromatin binding, histone acetyltransferase activity, nuclear estrogen receptor binding, nuclear receptor binding, nuclear retinoic acid receptor binding, nuclear retinoid X receptor binding, protein binding, protein dimerization activity, protein-containing complex binding, protein-lysine-acetyltransferase activity, transcription coactivator activity, transferase activity; CC: RNA polymerase II transcription regulator complex, chromatin, cytosol, nucleoplasm, nucleus, plasma membrane, protein-containing complex, transcription regulator complex
Pathways: Bile acid and bile salt metabolism, Biological oxidations, Breast cancer - Mus musculus (mouse), Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Chromatin modifying enzymes, Chromatin organization, Cytochrome P450 - arranged by substrate type, Cytoprotection by HMOX1, ESR-mediated signaling, Endogenous sterols, Estrogen signaling pathway - Mus musculus (mouse), Estrogen-dependent gene expression, HATs acetylate histones, Metabolism, Metabolism of lipids, Metabolism of proteins, Metabolism of steroids, NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis, NR1H2 and NR1H3-mediated signaling, NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux, Pathways in cancer - Mus musculus (mouse), Phase I - Functionalization of compounds, Post-translational protein modification, Recycling of bile acids and salts, Regulation of lipid metabolism by PPARalpha, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of transcription cofactors, Signal Transduction, Signaling by Nuclear Receptors, Synthesis of bile acids and bile salts, Synthesis of bile acids and bile salts via 27-hydroxycholesterol, Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol, Thyroid hormone signaling pathway - Mus musculus (mouse)
UniProt: P70365
Entrez ID: 17977
|
Does Knockout of Cul4a in Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,527
|
Knockout
|
Cul4a
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Cul4a (cullin 4A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, T cell activation, base-excision repair, AP site formation via deaminated base removal, cellular response to UV, developmental process, hemopoiesis, in utero embryonic development, miRNA-mediated gene silencing by mRNA destabilization, negative regulation of granulocyte differentiation, positive regulation of G1/S transition of mitotic cell cycle, positive regulation of cell population proliferation, positive regulation of protein catabolic process, proteasome-mediated ubiquitin-dependent protein catabolic process, protein ubiquitination, regulation of DNA damage checkpoint, regulation of nucleotide-excision repair, regulation of protein metabolic process, rhythmic process, ribosome biogenesis, somatic stem cell population maintenance, spermatogenesis, type I interferon-mediated signaling pathway, ubiquitin-dependent protein catabolic process, ubiquitin-dependent protein catabolic process via the C-end degron rule pathway; MF: protein binding, ubiquitin ligase complex scaffold activity, ubiquitin protein ligase activity, ubiquitin protein ligase binding; CC: Cul4-RING E3 ubiquitin ligase complex, Cul4A-RING E3 ubiquitin ligase complex, cullin-RING ubiquitin ligase complex, cytoplasm, nucleus
Pathways: DNA Damage Bypass, DNA Damage Recognition in GG-NER, DNA Repair, Dual Incision in GG-NER, Dual incision in TC-NER, Formation of Incision Complex in GG-NER, Formation of TC-NER Pre-Incision Complex, Gap-filling DNA repair synthesis and ligation in TC-NER, Global Genome Nucleotide Excision Repair (GG-NER), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Metabolism of proteins, Neddylation, Nucleotide Excision Repair, Nucleotide excision repair - Mus musculus (mouse), Post-translational protein modification, Recognition of DNA damage by PCNA-containing replication complex, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: Q3TCH7
Entrez ID: 99375
|
Does Knockout of Fam98b in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,265
|
Knockout
|
Fam98b
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Fam98b (family with sequence similarity 98, member B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of cell population proliferation, positive regulation of gene expression, protein methylation; MF: identical protein binding, protein methyltransferase activity; CC: cytoplasm, nucleoplasm, nucleus, tRNA-splicing ligase complex
Pathways:
UniProt: Q80VD1
Entrez ID: 68215
|
Does Knockout of Hdhd5 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Hdhd5
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Hdhd5 (haloacid dehalogenase like hydrolase domain containing 5)
Type: protein-coding
Summary: Predicted to be involved in glycerophospholipid biosynthetic process. Located in mitochondrion. Is expressed in brain. Orthologous to human HDHD5 (haloacid dehalogenase like hydrolase domain containing 5). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: CC: mitochondrion
Pathways:
UniProt: Q91WM2
Entrez ID: 214932
|
Does Knockout of Sostdc1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 2,477
|
Knockout
|
Sostdc1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Sostdc1 (sclerostin domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: BMP signaling pathway, Wnt signaling pathway, epithelial cell fate commitment, hair follicle morphogenesis, mammary gland bud morphogenesis, negative regulation of BMP signaling pathway, negative regulation of Wnt signaling pathway, negative regulation of canonical Wnt signaling pathway, negative regulation of cell differentiation, negative regulation of cell fate commitment, negative regulation of determination of dorsal identity, negative regulation of myoblast differentiation, odontogenesis of dentin-containing tooth, pattern specification process; MF: BMP binding, BMP receptor activity, protein binding; CC: extracellular region, extracellular space
Pathways:
UniProt: Q9CQN4
Entrez ID: 66042
|
Does Knockout of Lasp1 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Lasp1
|
phagocytosis
|
macrophage
|
Gene: Lasp1 (LIM and SH3 protein 1)
Type: protein-coding
Summary: Enables actin filament binding activity. Predicted to be involved in monoatomic ion transport. Located in cytoplasm and focal adhesion. Is expressed in several structures, including alimentary system; bone; central nervous system; genitourinary system; and hemolymphoid system gland. Orthologous to human LASP1 (LIM and SH3 protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: monoatomic ion transmembrane transport, monoatomic ion transport; MF: actin binding, actin filament binding, metal ion binding, monoatomic ion transmembrane transporter activity, protein binding; CC: cell cortex, cortical actin cytoskeleton, cytoplasm, cytoskeleton, focal adhesion, postsynapse
Pathways:
UniProt: Q61792
Entrez ID: 16796
|
Does Knockout of Sil1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Sil1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Sil1 (SIL1 nucleotide exchange factor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: adenyl-nucleotide exchange factor activity, identical protein binding; CC: endoplasmic reticulum, endoplasmic reticulum lumen
Pathways: Protein processing in endoplasmic reticulum - Mus musculus (mouse)
UniProt: Q9EPK6
Entrez ID: 81500
|
Does Knockout of Mast1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,275
|
Knockout
|
Mast1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Mast1 (microtubule associated serine/threonine kinase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: brain development, cytoskeleton organization, developmental process, intracellular signal transduction, protein phosphorylation; MF: ATP binding, kinase activity, magnesium ion binding, metal ion binding, microtubule binding, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: axon, cell projection, cytoplasm, cytoskeleton, dendrite, membrane, microtubule cytoskeleton, neuron projection, neuronal cell body, plasma membrane
Pathways:
UniProt: Q9R1L5
Entrez ID: 56527
|
Does Knockout of Defa30 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Defa30
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Defa30 (defensin, alpha, 30)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: antibacterial humoral response, antimicrobial humoral immune response mediated by antimicrobial peptide, defense response, defense response to Gram-negative bacterium, defense response to Gram-positive bacterium, defense response to bacterium, disruption of plasma membrane integrity in another organism, innate immune response, killing by host of symbiont cells, killing of cells of another organism, positive regulation of interleukin-8 production, positive regulation of membrane permeability, protein homotetramerization; MF: pore-forming activity, protein homodimerization activity; CC: extracellular region, extracellular space, midbody, secretory granule
Pathways: Alpha-defensins, Antimicrobial peptides, Defensins, Immune System, Innate Immune System, NOD-like receptor signaling pathway - Mus musculus (mouse), Neutrophil degranulation, Staphylococcus aureus infection - Mus musculus (mouse), Transcriptional misregulation in cancer - Mus musculus (mouse)
UniProt: E9QPZ2
Entrez ID: 100038927
|
Does Knockout of Gm14744 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Gm14744
|
phagocytosis
|
macrophage
|
Gene: Gm14744 (predicted gene 14744)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: molecular_function, odorant binding, pheromone binding, small molecule binding; CC: extracellular region, extracellular space
Pathways:
UniProt: B1AVU4
Entrez ID: 628923
|
Does Knockout of Lrch2 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
Lrch2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Lrch2 (leucine-rich repeats and calponin homology (CH) domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q3UMG5
Entrez ID: 210297
|
Does Knockout of Tmod2 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Tmod2
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Tmod2 (tropomodulin 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin filament organization, learning or memory, muscle contraction, myofibril assembly, neuron-neuron synaptic transmission, pointed-end actin filament capping, positive regulation of G protein-coupled receptor signaling pathway; MF: actin binding, tropomyosin binding; CC: cytoplasm, cytoskeleton, growth cone, myofibril, striated muscle thin filament, synapse
Pathways: Muscle contraction, Striated Muscle Contraction
UniProt: Q9JKK7
Entrez ID: 50876
|
Does Knockout of Cldn20 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,273
|
Knockout
|
Cldn20
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Cldn20 (claudin 20)
Type: protein-coding
Summary: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is identified in retinal pigment epithelium (RPE) and analysis of the RPE transcriptome reveals that this gene expression appears late during development of chick embryo. [provided by RefSeq, Aug 2010].
Gene Ontology:
Pathways: Cell adhesion molecules - Mus musculus (mouse), Hepatitis C - Mus musculus (mouse), Leukocyte transendothelial migration - Mus musculus (mouse), Tight junction - Mus musculus (mouse)
UniProt:
Entrez ID: 621628
|
Does Knockout of Map3k14 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 165
|
Knockout
|
Map3k14
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Map3k14 (mitogen-activated protein kinase kinase kinase 14)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: MAPK cascade, cellular response to mechanical stimulus, defense response to virus, immune response, non-canonical NF-kappaB signal transduction; MF: ATP binding, MAP kinase kinase kinase activity, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cytoplasm, cytosol, fibrillar center, nucleoplasm
Pathways: Adaptive Immune System, Alcoholic liver disease - Mus musculus (mouse), Apoptosis - Mus musculus (mouse), C-type lectin receptor signaling pathway - Mus musculus (mouse), C-type lectin receptors (CLRs), CD28 dependent PI3K/Akt signaling, CLEC7A (Dectin-1) signaling, Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Co-stimulation by CD28, Cytokine Signaling in Immune system, Dectin-1 mediated noncanonical NF-kB signaling, Epstein-Barr virus infection - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Immune System, Innate Immune System, Intestinal immune network for IgA production - Mus musculus (mouse), MAPK signaling pathway - Mus musculus (mouse), NF-kappa B signaling pathway - Mus musculus (mouse), NIK-->noncanonical NF-kB signaling, Osteoclast differentiation - Mus musculus (mouse), Regulation of T cell activation by CD28 family, T cell receptor signaling pathway - Mus musculus (mouse), TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway, TNF signaling pathway - Mus musculus (mouse), TNFR2 non-canonical NF-kB pathway
UniProt: Q9WUL6
Entrez ID: 53859
|
Does Knockout of Tulp1 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Tulp1
|
phagocytosis
|
macrophage
|
Gene: Tulp1 (TUB like protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: dendrite development, detection of light stimulus involved in visual perception, eye photoreceptor cell development, phagocytosis, phagocytosis, recognition, photoreceptor cell maintenance, positive regulation of phagocytosis, protein localization to cilium, protein localization to photoreceptor outer segment, retina development in camera-type eye, retina homeostasis, vesicle-mediated transport, visual perception; MF: actin filament binding, phosphatidylinositol-4,5-bisphosphate binding, protein binding; CC: axon terminus, cell projection, cilium, cytoplasm, cytosol, extracellular region, membrane, photoreceptor inner segment, photoreceptor outer segment, plasma membrane, synapse
Pathways:
UniProt: Q9Z273
Entrez ID: 22157
|
Does Knockout of Riok1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Riok1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Riok1 (RIO kinase 1)
Type: protein-coding
Summary: This gene encodes a member of the RIO family of atypical serine protein kinases. A similar protein in humans is a component of the protein arginine methyltransferase 5 complex that specifically recruits the RNA-binding protein nucleolin as a methylation substrate. [provided by RefSeq, Feb 2011].
Gene Ontology: BP: maturation of SSU-rRNA, positive regulation of rRNA processing, ribosomal small subunit biogenesis, ribosome biogenesis; MF: ATP binding, ATP hydrolysis activity, catalytic activity, hydrolase activity, kinase activity, metal ion binding, nucleotide binding, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cytoplasm, cytosol, methyltransferase complex, preribosome, small subunit precursor
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Ribosome biogenesis in eukaryotes - Mus musculus (mouse), rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q922Q2
Entrez ID: 71340
|
Does Knockout of Vmn2r110 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
Vmn2r110
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Vmn2r110 (vomeronasal 2, receptor 110)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, signal transduction; MF: G protein-coupled receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: A0A3B2W3V0, E9PWD5, A0A3B2WCK1
Entrez ID: 224582
|
Does Knockout of Anp32a in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Anp32a
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Anp32a (acidic nuclear phosphoprotein 32 family member A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of plasma membrane bounded cell projection assembly, nucleocytoplasmic transport, regulation of apoptotic process; MF: cell adhesion molecule binding, histone binding, integrin binding, protein binding; CC: chromatin, cytoplasm, endoplasmic reticulum, nuclear matrix, nucleus, perinuclear region of cytoplasm
Pathways: HuR (ELAVL1) binds and stabilizes mRNA, Metabolism of RNA, Regulation of mRNA stability by proteins that bind AU-rich elements
UniProt: O35381
Entrez ID: 11737
|
Does Knockout of Ewsr1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Ewsr1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Ewsr1 (Ewing sarcoma breakpoint region 1)
Type: protein-coding
Summary: Predicted to enable RNA binding activity; identical protein binding activity; and transcription coregulator activity. Predicted to be involved in regulation of DNA-templated transcription. Located in nucleus. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; hemolymphoid system gland; and sensory organ. Human ortholog(s) of this gene implicated in Ewing sarcoma. Orthologous to human EWSR1 (EWS RNA binding protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: MF: RNA binding, calmodulin binding, identical protein binding, metal ion binding, nucleic acid binding, protein binding, transcription coregulator activity, zinc ion binding; CC: Cajal body, cytoplasm, membrane, nucleolus, nucleoplasm, nucleus, plasma membrane
Pathways: Transcriptional misregulation in cancer - Mus musculus (mouse)
UniProt: Q61545
Entrez ID: 14030
|
Does Knockout of Kmt2d in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 1,130
|
Knockout
|
Kmt2d
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Kmt2d (lysine (K)-specific methyltransferase 2D)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, developmental growth, heterochromatin formation, in utero embryonic development, methylation, oocyte growth, oogenesis, positive regulation of cell population proliferation, positive regulation of intracellular estrogen receptor signaling pathway, positive regulation of transcription by RNA polymerase II, regulation of gene expression, response to estrogen; MF: DNA-binding transcription activator activity, RNA polymerase II-specific, histone H3K4 methyltransferase activity, histone H3K4 monomethyltransferase activity, histone H3K4 trimethyltransferase activity, metal ion binding, methyltransferase activity, protein binding, transcription cis-regulatory region binding, transcription coactivator activity, transferase activity, zinc ion binding; CC: MLL3/4 complex, histone methyltransferase complex, nucleoplasm, nucleus
Pathways: Cushing syndrome - Mus musculus (mouse), Lysine degradation - Mus musculus (mouse)
UniProt: Q6PDK2
Entrez ID: 381022
|
Does Knockout of Scn1b in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Scn1b
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Scn1b (sodium channel, voltage-gated, type I, beta)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: axon guidance, cardiac conduction, cardiac muscle cell action potential involved in contraction, cardiac muscle contraction, corticospinal neuron axon guidance, locomotion, membrane depolarization, membrane depolarization during Purkinje myocyte cell action potential, membrane depolarization during action potential, membrane depolarization during cardiac muscle cell action potential, monoatomic ion transport, neuronal action potential propagation, positive regulation of neuron projection development, positive regulation of sodium ion transport, positive regulation of voltage-gated sodium channel activity, regulation of atrial cardiac muscle cell membrane depolarization, regulation of heart rate by cardiac conduction, regulation of sodium ion transmembrane transport, regulation of sodium ion transport, regulation of ventricular cardiac muscle cell membrane repolarization, response to pyrethroid, sodium ion transmembrane transport, sodium ion transport; MF: protein binding, sodium channel inhibitor activity, sodium channel regulator activity, transmembrane transporter binding; CC: T-tubule, axon, cell projection, intercalated disc, membrane, node of Ranvier, perikaryon, plasma membrane, sodium channel complex, voltage-gated sodium channel complex
Pathways: Adrenergic signaling in cardiomyocytes - Mus musculus (mouse)
UniProt: P97952
Entrez ID: 20266
|
Does Knockout of Slc16a4 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Slc16a4
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Slc16a4 (solute carrier family 16 (monocarboxylic acid transporters), member 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: carboxylic acid transmembrane transport, monocarboxylic acid transport, transmembrane transport; MF: monocarboxylic acid transmembrane transporter activity, symporter activity, transmembrane transporter activity; CC: membrane, plasma membrane
Pathways:
UniProt: Q8R0M8
Entrez ID: 229699
|
Does Knockout of Dennd1c in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Dennd1c
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Dennd1c (DENN domain containing 1C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: endocytic recycling, endocytosis; MF: guanyl-nucleotide exchange factor activity, phosphatidylinositol phosphate binding, small GTPase binding; CC: centrosome, clathrin-coated vesicle, cytoplasm, cytoplasmic vesicle, cytosol, intracellular membrane-bounded organelle, nucleoplasm
Pathways: Membrane Trafficking, RAB GEFs exchange GTP for GDP on RABs, Rab regulation of trafficking, Vesicle-mediated transport
UniProt: Q8CFK6
Entrez ID: 70785
|
Does Knockout of Tdpoz4 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
Tdpoz4
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Tdpoz4 (TD and POZ domain containing 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: proteasome-mediated ubiquitin-dependent protein catabolic process, protein catabolic process, protein polyubiquitination, regulation of proteolysis; MF: identical protein binding, molecular function inhibitor activity, ubiquitin protein ligase binding; CC: Cul3-RING ubiquitin ligase complex, cytoplasm, nucleus
Pathways: Hedgehog signaling pathway - Mus musculus (mouse)
UniProt: Q6YCH2
Entrez ID: 399675
|
Does Knockout of Dnajc19 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Dnajc19
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Dnajc19 (DnaJ heat shock protein family (Hsp40) member C19)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: genitalia development, protein import into mitochondrial matrix, protein transport, regulation of cardiolipin metabolic process, visual perception; MF: ATPase activator activity, protein binding; CC: PAM complex, Tim23 associated import motor, inner mitochondrial membrane protein complex, matrix side of mitochondrial inner membrane, membrane, mitochondrial inner membrane, mitochondrion
Pathways:
UniProt: Q9CQV7
Entrez ID: 67713
|
Does Knockout of Pcyt1a in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,264
|
Knockout
|
Pcyt1a
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Pcyt1a (phosphate cytidylyltransferase 1, choline, alpha isoform)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell proliferation, CDP-choline pathway, isotype switching, lipid metabolic process, phosphatidylcholine biosynthetic process, phospholipid biosynthetic process; MF: calmodulin binding, catalytic activity, choline-phosphate cytidylyltransferase activity, identical protein binding, lipid binding, molecular function inhibitor activity, nucleotidyltransferase activity, phosphatidylcholine binding, protein binding, protein homodimerization activity, transferase activity; CC: cytoplasm, cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, glycogen granule, membrane, nuclear envelope, nucleus
Pathways: Choline metabolism in cancer - Mus musculus (mouse), Glycerophospholipid biosynthesis, Glycerophospholipid metabolism - Mus musculus (mouse), Metabolism, Metabolism of lipids, Phospholipid metabolism, Phosphonate and phosphinate metabolism - Mus musculus (mouse), Synthesis of PC, choline biosynthesis III, phosphatidylcholine biosynthesis I
UniProt: P49586
Entrez ID: 13026
|
Does Knockout of Pde4a in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Pde4a
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Pde4a (phosphodiesterase 4A, cAMP specific)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cAMP catabolic process, cellular response to xenobiotic stimulus, modulation of chemical synaptic transmission, negative regulation of cAMP/PKA signal transduction, regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway, regulation of cAMP/PKA signal transduction, sensory perception of smell, signal transduction; MF: 3',5'-cyclic-AMP phosphodiesterase activity, 3',5'-cyclic-GMP phosphodiesterase activity, 3',5'-cyclic-nucleotide phosphodiesterase activity, TPR domain binding, cAMP binding, hydrolase activity, metal ion binding, phosphoric diester hydrolase activity; CC: Schaffer collateral - CA1 synapse, cytoplasm, cytosol, extrinsic component of membrane, membrane, nucleoplasm, perinuclear region of cytoplasm, plasma membrane
Pathways: DARPP-32 events, G alpha (i) signalling events, G alpha (s) signalling events, GPCR downstream signalling, Morphine addiction - Mus musculus (mouse), Opioid Signalling, Parathyroid hormone synthesis, secretion and action - Mus musculus (mouse), Purine metabolism - Mus musculus (mouse), Signal Transduction, Signaling by GPCR, cAMP signaling pathway - Mus musculus (mouse)
UniProt: O89084
Entrez ID: 18577
|
Does Knockout of Srp68 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Srp68
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Srp68 (signal recognition particle 68)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: SRP-dependent cotranslational protein targeting to membrane, response to xenobiotic stimulus; MF: 7S RNA binding, RNA binding, endoplasmic reticulum signal peptide binding, protein domain specific binding, ribosome binding, signal recognition particle binding; CC: cytoplasm, cytosol, endoplasmic reticulum, focal adhesion, nucleolus, nucleus, ribonucleoprotein complex, signal recognition particle, signal recognition particle, endoplasmic reticulum targeting
Pathways: Metabolism of proteins, Protein export - Mus musculus (mouse), SRP-dependent cotranslational protein targeting to membrane, Translation
UniProt: Q8BMA6
Entrez ID: 217337
|
Does Knockout of Pold2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Pold2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Pold2 (polymerase (DNA directed), delta 2, regulatory subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA biosynthetic process, DNA damage response, DNA metabolic process, DNA repair, DNA replication, DNA strand elongation involved in DNA replication, DNA-templated DNA replication, error-prone translesion synthesis; CC: delta DNA polymerase complex, nucleoplasm, nucleus, zeta DNA polymerase complex
Pathways: Base Excision Repair, Base excision repair - Mus musculus (mouse), Cell Cycle, Cell Cycle, Mitotic, Chromosome Maintenance, DNA Damage Bypass, DNA Double-Strand Break Repair, DNA Repair, DNA Replication, DNA replication - Mus musculus (mouse), DNA strand elongation, Dual Incision in GG-NER, Dual incision in TC-NER, Extension of Telomeres, Gap-filling DNA repair synthesis and ligation in GG-NER, Gap-filling DNA repair synthesis and ligation in TC-NER, Global Genome Nucleotide Excision Repair (GG-NER), HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homologous recombination - Mus musculus (mouse), Homology Directed Repair, Lagging Strand Synthesis, Leading Strand Synthesis, Mismatch Repair, Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta), Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha), Mismatch repair - Mus musculus (mouse), Nucleotide Excision Repair, Nucleotide excision repair - Mus musculus (mouse), PCNA-Dependent Long Patch Base Excision Repair, Polymerase switching, Polymerase switching on the C-strand of the telomere, Processive synthesis on the C-strand of the telomere, Processive synthesis on the lagging strand, Recognition of DNA damage by PCNA-containing replication complex, Removal of the Flap Intermediate, Removal of the Flap Intermediate from the C-strand, Resolution of AP sites via the multiple-nucleotide patch replacement pathway, Resolution of Abasic Sites (AP sites), S Phase, Synthesis of DNA, Telomere C-strand (Lagging Strand) Synthesis, Telomere Maintenance, Termination of translesion DNA synthesis, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
UniProt: O35654
Entrez ID: 18972
|
Does Knockout of Pcnx3 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Pcnx3
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Pcnx3 (pecanex homolog 3)
Type: protein-coding
Summary: Predicted to be located in membrane. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and hemolymphoid system. Orthologous to human PCNX3 (pecanex 3). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: CC: cellular_component, membrane
Pathways:
UniProt: Q8VI59
Entrez ID: 104401
|
Does Knockout of Farsb in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,262
|
Knockout
|
Farsb
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Farsb (phenylalanyl-tRNA synthetase, beta subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: phenylalanyl-tRNA aminoacylation, protein heterotetramerization, translation; MF: ATP binding, RNA binding, aminoacyl-tRNA ligase activity, ligase activity, magnesium ion binding, metal ion binding, nucleotide binding, phenylalanine-tRNA ligase activity; CC: cytoplasm, phenylalanine-tRNA ligase complex
Pathways: Aminoacyl-tRNA biosynthesis - Mus musculus (mouse), tRNA charging pathway
UniProt: Q9WUA2
Entrez ID: 23874
|
Does Knockout of Syp in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Syp
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Syp (synaptophysin)
Type: protein-coding
Summary: Enables SH2 domain binding activity and identical protein binding activity. Involved in regulation of long-term neuronal synaptic plasticity; regulation of short-term neuronal synaptic plasticity; and regulation of synaptic vesicle priming. Located in several cellular components, including neuromuscular junction; presynaptic membrane; and synaptic vesicle membrane. Is active in Schaffer collateral - CA1 synapse and presynaptic active zone. Is expressed in several structures, including diaphragm; gut; nervous system; sensory organ; and skeletal muscle. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 96. Orthologous to human SYP (synaptophysin). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: chemical synaptic transmission, endocytosis, modulation of chemical synaptic transmission, protein homooligomerization, regulation of long-term neuronal synaptic plasticity, regulation of neuronal synaptic plasticity, regulation of opioid receptor signaling pathway, regulation of short-term neuronal synaptic plasticity, regulation of synaptic vesicle priming; MF: SH2 domain binding, SNARE binding, cholesterol binding, identical protein binding, protein binding, protein domain specific binding, protein-containing complex binding, syntaxin-1 binding; CC: Schaffer collateral - CA1 synapse, clathrin-sculpted glutamate transport vesicle membrane, cytoplasmic vesicle, excitatory synapse, membrane, neuromuscular junction, neuron projection, neuron projection terminus, neuron spine, perinuclear region of cytoplasm, postsynaptic density, presynapse, presynaptic active zone, presynaptic membrane, protein-containing complex, synapse, synaptic vesicle, synaptic vesicle membrane, terminal bouton
Pathways:
UniProt: Q62277
Entrez ID: 20977
|
Does Knockout of Mmel1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Mmel1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Mmel1 (membrane metallo-endopeptidase-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein processing, proteolysis; MF: endopeptidase activity, hydrolase activity, metal ion binding, metalloendopeptidase activity, metallopeptidase activity, peptidase activity, zinc ion binding; CC: Golgi apparatus, endoplasmic reticulum, extracellular region, extracellular space, membrane, plasma membrane
Pathways:
UniProt: Q9JLI3
Entrez ID: 27390
|
Does Knockout of Slc24a5 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
Slc24a5
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Slc24a5 (solute carrier family 24, member 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: calcium ion import, calcium ion transmembrane transport, calcium ion transport, intracellular calcium ion homeostasis, monoatomic ion transmembrane transport, monoatomic ion transport, negative regulation of melanin biosynthetic process, potassium ion transmembrane transport, potassium ion transport, sodium ion transmembrane transport, sodium ion transport, transmembrane transport; MF: antiporter activity, calcium channel activity, calcium ion transmembrane transporter activity, calcium, potassium:sodium antiporter activity, symporter activity; CC: Golgi apparatus, melanosome, membrane, trans-Golgi network
Pathways: Metal ion SLC transporters, SLC-mediated transmembrane transport, Sodium/Calcium exchangers, Transport of small molecules
UniProt: Q8C261
Entrez ID: 317750
|
Does Knockout of Ung in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Ung
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Ung (uracil DNA glycosylase)
Type: protein-coding
Summary: Enables uracil DNA N-glycosylase activity. Acts upstream of or within isotype switching and somatic hypermutation of immunoglobulin genes. Located in mitochondrion and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; lung; and olfactory epithelium. Human ortholog(s) of this gene implicated in dysgammaglobulinemia and immunodeficiency with hyper IgM type 5. Orthologous to human UNG (uracil DNA glycosylase). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: DNA damage response, DNA repair, base-excision repair, base-excision repair, AP site formation via deaminated base removal, isotype switching, negative regulation of apoptotic process, somatic hypermutation of immunoglobulin genes, somatic recombination of immunoglobulin gene segments; MF: damaged DNA binding, hydrolase activity, hydrolase activity, hydrolyzing N-glycosyl compounds, ribosomal small subunit binding, uracil DNA N-glycosylase activity; CC: mitochondrion, nucleoplasm, nucleus
Pathways: Base Excision Repair, Base excision repair - Mus musculus (mouse), Base-Excision Repair, AP Site Formation, Cleavage of the damaged pyrimidine , DNA Repair, Depyrimidination, Displacement of DNA glycosylase by APEX1, Primary immunodeficiency - Mus musculus (mouse), Resolution of Abasic Sites (AP sites), purine and pyrimidine metabolism, pyrimidine ribonucleosides degradation II
UniProt: P97931
Entrez ID: 22256
|
Does Knockout of Tirap in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Tirap
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Tirap (toll-interleukin 1 receptor (TIR) domain-containing adaptor protein)
Type: protein-coding
Summary: Enables several functions, including Toll-like receptor 2 binding activity; identical protein binding activity; and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in several processes, including positive regulation of B cell proliferation; positive regulation of innate immune response; and regulation of cytokine production. Acts upstream of or within several processes, including myeloid cell differentiation; positive regulation of macrophage cytokine production; and response to bacterium. Located in endocytic vesicle and ruffle membrane. Is expressed in testis. Human ortholog(s) of this gene implicated in malaria and tuberculosis. Orthologous to human TIRAP (TIR domain containing adaptor protein). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: 3'-UTR-mediated mRNA stabilization, TIRAP-dependent toll-like receptor 4 signaling pathway, cell surface receptor signaling pathway, cellular response to bacterial lipopeptide, cellular response to lipoteichoic acid, defense response to Gram-positive bacterium, immune system process, inflammatory response, innate immune response, interleukin-1-mediated signaling pathway, myeloid cell differentiation, positive regulation of B cell proliferation, positive regulation of ERK1 and ERK2 cascade, positive regulation of JNK cascade, positive regulation of canonical NF-kappaB signal transduction, positive regulation of chemokine (C-X-C motif) ligand 1 production, positive regulation of chemokine (C-X-C motif) ligand 2 production, positive regulation of innate immune response, positive regulation of interleukin-12 production, positive regulation of interleukin-15 production, positive regulation of interleukin-6 production, positive regulation of interleukin-8 production, positive regulation of macrophage cytokine production, positive regulation of neutrophil chemotaxis, positive regulation of protein-containing complex assembly, positive regulation of toll-like receptor 2 signaling pathway, positive regulation of toll-like receptor 3 signaling pathway, positive regulation of toll-like receptor 4 signaling pathway, positive regulation of tumor necrosis factor production, regulation of innate immune response, regulation of interferon-beta production, regulation of interleukin-15 production, response to bacterium, response to lipopolysaccharide, signal transduction, toll-like receptor 4 signaling pathway, toll-like receptor 5 signaling pathway; MF: Toll-like receptor 2 binding, Toll-like receptor 4 binding, identical protein binding, molecular adaptor activity, phosphatidylinositol-4,5-bisphosphate binding, protein binding, protein kinase C binding, signaling adaptor activity; CC: cell surface, cytoplasm, endocytic vesicle, extrinsic component of cytoplasmic side of plasma membrane, membrane, peroxisome, plasma membrane, ruffle membrane
Pathways: Alcoholic liver disease - Mus musculus (mouse), Hepatitis B - Mus musculus (mouse), Immune System, Innate Immune System, Lipid and atherosclerosis - Mus musculus (mouse), MyD88:MAL(TIRAP) cascade initiated on plasma membrane, NF-kappa B signaling pathway - Mus musculus (mouse), PD-L1 expression and PD-1 checkpoint pathway in cancer - Mus musculus (mouse), Pertussis - Mus musculus (mouse), Salmonella infection - Mus musculus (mouse), Toll Like Receptor 2 (TLR2) Cascade, Toll Like Receptor 4 (TLR4) Cascade, Toll Like Receptor TLR1:TLR2 Cascade, Toll Like Receptor TLR6:TLR2 Cascade, Toll-like Receptor Cascades, Toll-like receptor signaling pathway - Mus musculus (mouse), Tuberculosis - Mus musculus (mouse)
UniProt: Q99JY1
Entrez ID: 117149
|
Does Knockout of Glrx5 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 579
|
Knockout
|
Glrx5
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Glrx5 (glutaredoxin 5)
Type: protein-coding
Summary: This gene encodes a mitochondrial protein, which is evolutionarily conserved. It is involved in the biogenesis of iron-sulfur clusters, which are required for normal iron homeostasis. Mutations in the human gene are associated with autosomal recessive pyridoxine-refractory sideroblastic anemia. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: [2Fe-2S] cluster assembly, hemopoiesis, protein maturation; MF: 2 iron, 2 sulfur cluster binding, iron-sulfur cluster binding, metal ion binding; CC: dendrite, iron-sulfur cluster assembly complex, mitochondrial matrix, mitochondrion, neuronal cell body
Pathways: Metabolism, Mitochondrial iron-sulfur cluster biogenesis
UniProt: Q80Y14
Entrez ID: 73046
|
Does Knockout of Etfdh in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Etfdh
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Etfdh (electron transferring flavoprotein, dehydrogenase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: electron transport chain, fatty acid beta-oxidation using acyl-CoA dehydrogenase, respiratory electron transport chain, response to oxidative stress; MF: 4 iron, 4 sulfur cluster binding, electron transfer activity, electron-transferring-flavoprotein dehydrogenase activity, iron-sulfur cluster binding, metal ion binding, oxidoreductase activity, quinone binding, ubiquinone binding; CC: cytosol, membrane, mitochondrial electron transfer flavoprotein complex, mitochondrial inner membrane, mitochondrial membrane, mitochondrion, nucleoplasm
Pathways: Aerobic respiration and respiratory electron transport, Metabolism, Respiratory electron transport
UniProt: Q921G7
Entrez ID: 66841
|
Does Knockout of Impdh2 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Impdh2
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Impdh2 (inosine monophosphate dehydrogenase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 'de novo' XMP biosynthetic process, GMP biosynthetic process, GMP salvage, GTP biosynthetic process, cellular response to interleukin-4, circadian rhythm, lymphocyte proliferation, purine nucleotide biosynthetic process; MF: DNA binding, IMP dehydrogenase activity, RNA binding, catalytic activity, identical protein binding, metal ion binding, nucleotide binding, oxidoreductase activity; CC: cytoplasm, cytosol, nucleus
Pathways: Azathioprine ADME, Drug ADME, Drug metabolism - other enzymes - Mus musculus (mouse), Immune System, Innate Immune System, Metabolism, Metabolism of nucleotides, Neutrophil degranulation, Nucleotide biosynthesis, Purine metabolism - Mus musculus (mouse), Purine ribonucleoside monophosphate biosynthesis, purine nucleotides degradation II (aerobic), urate biosynthesis/inosine 5,-phosphate degradation, ureide biosynthesis
UniProt: P24547
Entrez ID: 23918
|
Does Knockout of Ppp1r3c in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Ppp1r3c
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Ppp1r3c (protein phosphatase 1, regulatory subunit 3C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: glycogen biosynthetic process, glycogen metabolic process, protein targeting, regulation of glycogen biosynthetic process, regulation of glycogen catabolic process; MF: [phosphorylase] phosphatase activity, enzyme binding, glycogen binding, molecular adaptor activity, phosphoprotein phosphatase activity, protein phosphatase 1 binding, protein phosphatase binding; CC: cytosol, glycogen granule, protein phosphatase type 1 complex
Pathways: Glycogen metabolism, Glycogen synthesis, Insulin resistance - Mus musculus (mouse), Insulin signaling pathway - Mus musculus (mouse), Metabolism, Metabolism of carbohydrates and carbohydrate derivatives
UniProt: Q7TMB3
Entrez ID: 53412
|
Does Knockout of Fbxo5 in Acute Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 684
|
Knockout
|
Fbxo5
|
cell proliferation
|
Acute Myeloid Leukemia Cell Line
|
Gene: Fbxo5 (F-box protein 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, cell division, meiotic nuclear division, microtubule polymerization, negative regulation of DNA endoreduplication, negative regulation of cellular senescence, negative regulation of meiotic nuclear division, negative regulation of mitotic metaphase/anaphase transition, negative regulation of ubiquitin protein ligase activity, negative regulation of ubiquitin-protein transferase activity, oocyte maturation, positive regulation of G2/M transition of mitotic cell cycle, positive regulation of biomineral tissue development, positive regulation of cell population proliferation, positive regulation of meiosis I, positive regulation of mesenchymal stem cell migration, positive regulation of osteoblast differentiation, protein ubiquitination, regulation of DNA replication, regulation of meiotic nuclear division, regulation of mitotic cell cycle, regulation of mitotic nuclear division, spindle assembly, spindle assembly involved in female meiosis I, vesicle organization; MF: anaphase-promoting complex binding, metal ion binding, molecular function inhibitor activity, protein binding, protein kinase binding, ubiquitin ligase inhibitor activity, zinc ion binding; CC: cytoplasm, cytoskeleton, meiotic spindle, nucleoplasm, nucleus, spindle
Pathways: APC/C-mediated degradation of cell cycle proteins, Cell Cycle, Cell Cycle, Mitotic, M Phase, Mitotic Metaphase and Anaphase, Mitotic Metaphase/Anaphase Transition, Oocyte meiosis - Mus musculus (mouse), Phosphorylation of Emi1, Regulation of APC/C activators between G1/S and early anaphase, Regulation of mitotic cell cycle, SCF-beta-TrCP mediated degradation of Emi1
UniProt: Q7TSG3
Entrez ID: 67141
|
Does Knockout of Pgls in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Pgls
|
phagocytosis
|
macrophage
|
Gene: Pgls (6-phosphogluconolactonase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: carbohydrate metabolic process, pentose-phosphate shunt, pentose-phosphate shunt, oxidative branch; MF: 6-phosphogluconolactonase activity, hydrolase activity, monosaccharide binding; CC: cytoplasm, cytosol
Pathways: Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Pentose phosphate pathway, Pentose phosphate pathway - Mus musculus (mouse), formaldehyde oxidation I, pentose phosphate pathway, pentose phosphate pathway (oxidative branch)
UniProt: Q9CQ60
Entrez ID: 66171
|
Does Knockout of Arhgap9 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Arhgap9
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Arhgap9 (Rho GTPase activating protein 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: signal transduction, small GTPase-mediated signal transduction; MF: GTPase activator activity, phosphatidylinositol-3,4,5-trisphosphate binding; CC: cytoplasm, plasma membrane
Pathways: CDC42 GTPase cycle, Immune System, Innate Immune System, Neutrophil degranulation, RAC1 GTPase cycle, RHO GTPase cycle, RHOA GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, cyclic AMP biosynthesis
UniProt: Q8QZW8, Q1HDU4, Q78T58
Entrez ID: 216445
|
Does Knockout of Tph1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 83
|
Knockout
|
Tph1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Tph1 (tryptophan hydroxylase 1)
Type: protein-coding
Summary: This gene encodes a member of the biopterin-dependent aromatic amino acid hydroxylase family. The encoded protein is one of two tryptophan hydroxylase enzymes that catalyze the first and rate limiting step in the biosynthesis of the hormone and neurotransmitter, serotonin. This gene is expressed in peripheral organs, while tryptophan hydroxylase 2 is expressed in neurons. The encoded protein is involved in the development of hypoxia-induced elevations in pulmonary pressures and pulmonary vascular remodeling, and has also been implicated as a regulator of immune tolerance. Disruption of this gene is associated with cardiac dysfunction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013].
Gene Ontology: BP: aromatic amino acid metabolic process, bone remodeling, mammary gland alveolus development, negative regulation of ossification, platelet degranulation, positive regulation of fat cell differentiation, regulation of hemostasis, serotonin biosynthetic process, serotonin biosynthetic process from tryptophan; MF: iron ion binding, metal ion binding, monooxygenase activity, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen, tryptophan 5-monooxygenase activity; CC: cytoplasm, neuron projection
Pathways: Folate biosynthesis - Mus musculus (mouse), Metabolism, Metabolism of amine-derived hormones, Metabolism of amino acids and derivatives, Serotonergic synapse - Mus musculus (mouse), Serotonin and melatonin biosynthesis, Tryptophan metabolism - Mus musculus (mouse), biosynthesis of serotonin and melatonin, serotonin and melatonin biosynthesis
UniProt: P17532
Entrez ID: 21990
|
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