prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Snx21 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Snx21
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Snx21 (sorting nexin family member 21)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, protein transport; MF: lipid binding, molecular_function, phosphatidylinositol binding, phosphatidylinositol phosphate binding, phosphatidylinositol-3-phosphate binding, phosphatidylinositol-4,5-bisphosphate binding; CC: cytoplasmic vesicle, cytoplasmic vesicle membrane, early endosome membrane, endosome, membrane
Pathways:
UniProt: Q3UR97
Entrez ID: 101113
|
Does Knockout of Atpaf2 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,262
|
Knockout
|
Atpaf2
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Atpaf2 (ATP synthase mitochondrial F1 complex assembly factor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial proton-transporting ATP synthase complex assembly, proton-transporting ATP synthase complex assembly; CC: cytosol, membrane, mitochondrial inner membrane, mitochondrion, nuclear speck
Pathways:
UniProt: Q91YY4
Entrez ID: 246782
|
Does Knockout of Flad1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Flad1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Flad1 (flavin adenine dinucleotide synthetase 1)
Type: protein-coding
Summary: Enables FMN adenylyltransferase activity. Involved in flavin adenine dinucleotide biosynthetic process and riboflavin metabolic process. Is active in cytosol. Orthologous to human FLAD1 (flavin adenine dinucleotide synthetase 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: FAD biosynthetic process, flavin adenine dinucleotide biosynthetic process, riboflavin metabolic process; MF: ATP binding, FAD diphosphatase activity, FMN adenylyltransferase activity, catalytic activity, identical protein binding, nucleotide binding, nucleotidyltransferase activity, transferase activity; CC: cytoplasm, cytosol, mitochondrial matrix, nucleus, plasma membrane
Pathways: Metabolism, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, Riboflavin metabolism - Mus musculus (mouse), Vitamin B2 (riboflavin) metabolism, flavin biosynthesis IV (mammalian), riboflavin, FMN and FAD transformations
UniProt: Q8R123
Entrez ID: 319945
|
Does Knockout of Fbf1 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Fbf1
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Fbf1 (Fas binding factor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apical junction assembly, cell projection organization, cilium assembly, establishment of epithelial cell polarity; CC: anchoring junction, apical junction complex, centriole, centrosome, ciliary basal body, ciliary transition fiber, cilium, cytoplasm, cytoskeleton, keratin filament, spindle pole
Pathways: Anchoring of the basal body to the plasma membrane, Cilium Assembly, Organelle biogenesis and maintenance
UniProt: A2A870
Entrez ID: 217335
|
Does Knockout of Hmga2 in Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,532
|
Knockout
|
Hmga2
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Hmga2 (high mobility group AT-hook 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adipose tissue development, adrenal gland development, base-excision repair, cell division, cell proliferation in forebrain, chondrocyte differentiation, chondrocyte proliferation, chromosome condensation, endodermal cell differentiation, epithelial to mesenchymal transition, epithelial tube branching involved in lung morphogenesis, fat cell differentiation, fat pad development, heterochromatin formation, host-mediated suppression of viral transcription, intracellular signal transduction, lung epithelium development, male gonad development, meiotic cell cycle, mesenchymal cell differentiation, mesodermal cell differentiation, mesodermal-endodermal cell signaling, multicellular organism growth, negative regulation of DNA binding, negative regulation of DNA-templated transcription, negative regulation of Wnt signaling pathway, negative regulation of apoptotic process, negative regulation of astrocyte differentiation, negative regulation of cellular senescence, negative regulation of double-strand break repair via nonhomologous end joining, negative regulation of intracellular steroid hormone receptor signaling pathway, negative regulation of receptor signaling pathway via JAK-STAT, negative regulation of single stranded viral RNA replication via double stranded DNA intermediate, negative regulation of transcription by RNA polymerase II, oncogene-induced cell senescence, pituitary gland development, positive regulation of DNA-templated transcription, positive regulation of angiogenesis, positive regulation of cell population proliferation, positive regulation of cell proliferation in bone marrow, positive regulation of epithelial cell proliferation involved in lung morphogenesis, positive regulation of fibroblast proliferation, positive regulation of gene expression, positive regulation of macromolecule biosynthetic process, positive regulation of multicellular organism growth, positive regulation of protein serine/threonine kinase activity, positive regulation of stem cell proliferation, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of cell cycle process, regulation of gene expression, regulation of growth hormone secretion, regulation of peptide hormone secretion, regulation of stem cell population maintenance, response to virus, somatic stem cell population maintenance, spermatogenesis, stem cell differentiation; MF: 5'-deoxyribose-5-phosphate lyase activity, C2H2 zinc finger domain binding, DNA binding, DNA binding, bending, DNA-(apurinic or apyrimidinic site) endonuclease activity, MH1 domain binding, MH2 domain binding, RNA polymerase II-specific DNA-binding transcription factor binding, SMAD binding, cAMP response element binding, enzyme binding, minor groove of adenine-thymine-rich DNA binding, nucleic acid binding, nucleosomal DNA binding, protein binding, transcription cis-regulatory region binding, transcription coregulator activity, transcription corepressor activity; CC: SMAD protein complex, chromatin, male germ cell nucleus, nuclear chromosome, nucleus, protein-DNA complex, senescence-associated heterochromatin focus
Pathways: Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, DNA Damage/Telomere Stress Induced Senescence, Formation of Senescence-Associated Heterochromatin Foci (SAHF), MicroRNAs in cancer - Mus musculus (mouse), Transcriptional misregulation in cancer - Mus musculus (mouse)
UniProt: P52927
Entrez ID: 15364
|
Does Knockout of Tas2r125 in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Tas2r125
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Tas2r125 (taste receptor, type 2, member 125)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, detection of chemical stimulus involved in sensory perception of bitter taste, detection of chemical stimulus involved in sensory perception of taste, sensory perception of bitter taste, sensory perception of taste, signal transduction; MF: G protein-coupled receptor activity, bitter taste receptor activity, taste receptor activity; CC: membrane
Pathways: Taste transduction - Mus musculus (mouse)
UniProt: Q7M710
Entrez ID: 387352
|
Does Knockout of H2-M10.6 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
H2-M10.6
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: H2-M10.6 (histocompatibility 2, M region locus 10.6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent, antigen processing and presentation of endogenous peptide antigen via MHC class Ib, antigen processing and presentation of peptide antigen via MHC class I, immune response, immune system process, positive regulation of T cell mediated cytotoxicity; MF: peptide antigen binding, signaling receptor binding; CC: MHC class I protein complex, external side of plasma membrane, extracellular space, lumenal side of endoplasmic reticulum membrane, membrane, phagocytic vesicle membrane
Pathways: Adaptive Immune System, Allograft rejection - Mus musculus (mouse), Antigen Presentation: Folding, assembly and peptide loading of class I MHC, Antigen processing and presentation - Mus musculus (mouse), Antigen processing-Cross presentation, Autoimmune thyroid disease - Mus musculus (mouse), Cell adhesion molecules - Mus musculus (mouse), Cellular senescence - Mus musculus (mouse), Class I MHC mediated antigen processing & presentation, DAP12 interactions, ER-Phagosome pathway, Endocytosis - Mus musculus (mouse), Endosomal/Vacuolar pathway, Epstein-Barr virus infection - Mus musculus (mouse), Graft-versus-host disease - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Immune System, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, Innate Immune System, Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Neutrophil degranulation, Phagosome - Mus musculus (mouse), Type I diabetes mellitus - Mus musculus (mouse), Viral carcinogenesis - Mus musculus (mouse), Viral myocarditis - Mus musculus (mouse)
UniProt: Q85ZW5
Entrez ID: 399549
|
Does Knockout of Csk in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Csk
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Csk (c-src tyrosine kinase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adaptive immune response, adherens junction organization, cellular response to peptide hormone stimulus, immune system process, intracellular signal transduction, negative regulation of ERK1 and ERK2 cascade, negative regulation of Golgi to plasma membrane protein transport, negative regulation of T cell activation, negative regulation of T cell receptor signaling pathway, negative regulation of bone resorption, negative regulation of cell population proliferation, negative regulation of interleukin-6 production, negative regulation of low-density lipoprotein particle clearance, negative regulation of phagocytosis, oligodendrocyte differentiation, regulation of Fc receptor mediated stimulatory signaling pathway, regulation of immune system process, regulation of multicellular organismal process; MF: ATP binding, identical protein binding, kinase activity, metal ion binding, non-membrane spanning protein tyrosine kinase activity, nucleotide binding, proline-rich region binding, protein binding, protein kinase A catalytic subunit binding, protein kinase activity, protein phosphatase binding, protein tyrosine kinase activity, protein tyrosine kinase binding, transferase activity; CC: cell-cell junction, cytoplasm, membrane, plasma membrane
Pathways: Adaptive Immune System, Co-inhibition by PD-1, Cytokine Signaling in Immune system, FLT3 Signaling, GAB1 signalosome, Hemostasis, Immune System, Integrin signaling, MAP2K and MAPK activation, MAPK family signaling cascades, MAPK1/MAPK3 signaling, Negative regulation of FLT3, Phosphorylation of CD3 and TCR zeta chains, Platelet Aggregation (Plug Formation), Platelet activation, signaling and aggregation, RAF/MAP kinase cascade, RHO GTPase cycle, RHOH GTPase cycle, Regulation of T cell activation by CD28 family, Signal Transduction, Signaling by EGFR, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, TCR signaling
UniProt: P41241
Entrez ID: 12988
|
Does Knockout of Fhdc1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Fhdc1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Fhdc1 (FH2 domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi ribbon formation, actin filament polymerization, cell projection organization, cilium assembly, stress fiber assembly; MF: actin binding, microtubule binding, protein binding; CC: Golgi apparatus, actin filament, cell projection, cilium, cytoplasmic microtubule, microtubule
Pathways:
UniProt: Q3ULZ2
Entrez ID: 229474
|
Does Knockout of Zfp474 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Zfp474
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Zfp474 (zinc finger protein 474)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: metal ion binding, molecular_function, zinc ion binding
Pathways:
UniProt: Q6V5K9
Entrez ID: 66758
|
Does Knockout of Fntb in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Fntb
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Fntb (farnesyltransferase, CAAX box, beta)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: lipid metabolic process, negative regulation of cell population proliferation, positive regulation of cell cycle, positive regulation of cell population proliferation, positive regulation of fibroblast proliferation, protein farnesylation, regulation of fibroblast proliferation, wound healing; MF: acetyltransferase activator activity, catalytic activity, enzyme binding, geranylgeranyl diphosphate synthase activity, metal ion binding, peptide binding, prenyltransferase activity, protein farnesyltransferase activity, protein prenyltransferase activity, transferase activity, zinc ion binding; CC: microtubule associated complex, protein farnesyltransferase complex
Pathways: Inactivation, recovery and regulation of the phototransduction cascade, MAPK family signaling cascades, MAPK1/MAPK3 signaling, RAF/MAP kinase cascade, RAS processing, Sensory Perception, Signal Transduction, Terpenoid backbone biosynthesis - Mus musculus (mouse), The phototransduction cascade, Visual phototransduction
UniProt: Q8K2I1
Entrez ID: 110606
|
Does Knockout of Frmd3 in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Frmd3
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Frmd3 (FERM domain containing 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cytoskeleton, membrane
Pathways:
UniProt: Q8BHD4
Entrez ID: 242506
|
Does Knockout of L3hypdh in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
L3hypdh
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: L3hypdh (L-3-hydroxyproline dehydratase (trans-))
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: hydro-lyase activity, lyase activity, proline racemase activity, trans-L-3-hydroxyproline dehydratase activity
Pathways: Arginine and proline metabolism - Mus musculus (mouse)
UniProt: Q9CXA2
Entrez ID: 67217
|
Does Knockout of Aplp1 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Aplp1
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Aplp1 (amyloid beta precursor like protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: animal organ development, apoptotic process, axonogenesis, cell adhesion, cellular response to norepinephrine stimulus, central nervous system development, cytosolic mRNA polyadenylation, endocytosis, extracellular matrix organization, forebrain development, negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway, nervous system development, regulation of translation; MF: alpha-2A adrenergic receptor binding, alpha-2B adrenergic receptor binding, alpha-2C adrenergic receptor binding, heparin binding, identical protein binding, metal ion binding, protein binding, transition metal ion binding; CC: Golgi apparatus, cytoplasm, membrane, nucleoplasm, perinuclear region of cytoplasm, plasma membrane
Pathways:
UniProt: Q03157
Entrez ID: 11803
|
Does Knockout of Glis1 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,273
|
Knockout
|
Glis1
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Glis1 (GLIS family zinc finger 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, fat cell differentiation, negative regulation of cell fate commitment, negative regulation of transcription by RNA polymerase II, osteoblast differentiation, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, metal ion binding, sequence-specific double-stranded DNA binding, zinc ion binding; CC: nucleus
Pathways:
UniProt: Q8K1M4
Entrez ID: 230587
|
Does Knockout of Ptpmt1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Ptpmt1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Ptpmt1 (protein tyrosine phosphatase, mitochondrial 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cardiolipin biosynthetic process, lipid metabolic process, negative regulation of insulin secretion involved in cellular response to glucose stimulus, phosphatidylglycerol biosynthetic process, phosphatidylinositol metabolic process, phospholipid biosynthetic process, regulation of intrinsic apoptotic signaling pathway; MF: hydrolase activity, phosphatidylglycerophosphatase activity, phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity, phosphatidylinositol-5-phosphate phosphatase activity, phosphoprotein phosphatase activity, protein serine/threonine phosphatase activity, protein tyrosine phosphatase activity; CC: cytoplasm, membrane, mitochondrial inner membrane, mitochondrion
Pathways:
UniProt: Q66GT5
Entrez ID: 66461
|
Does Knockout of Gata3 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Gata3
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Gata3 (GATA binding protein 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell differentiation, T cell differentiation in thymus, T cell receptor signaling pathway, T-helper 2 cell differentiation, TOR signaling, anatomical structure formation involved in morphogenesis, animal organ development, aortic valve morphogenesis, axon guidance, canonical Wnt signaling pathway, cardiac right ventricle morphogenesis, cartilage development, cell activation, cell differentiation, cell fate commitment, cell fate determination, cell maturation, cell morphogenesis, cellular response to BMP stimulus, cellular response to cytokine stimulus, cellular response to interferon-alpha, cellular response to interleukin-4, cellular response to tumor necrosis factor, chromatin remodeling, cochlea development, developmental growth, ear development, embryonic hemopoiesis, embryonic organ development, erythrocyte differentiation, gene expression, homeostasis of number of cells, humoral immune response, immune system development, immune system process, in utero embryonic development, inflammatory response, innate immune response, inner ear morphogenesis, kidney development, lens development in camera-type eye, lymphocyte migration, macrophage differentiation, male gonad development, mast cell differentiation, mesenchymal to epithelial transition, mesonephros development, negative regulation of DNA-templated transcription, negative regulation of cell cycle, negative regulation of cell motility, negative regulation of cell population proliferation, negative regulation of cell proliferation involved in mesonephros development, negative regulation of endothelial cell apoptotic process, negative regulation of epithelial to mesenchymal transition, negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation, negative regulation of gene expression, negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation, negative regulation of inflammatory response, negative regulation of interleukin-2 production, negative regulation of mammary gland epithelial cell proliferation, negative regulation of transcription by RNA polymerase II, negative regulation of type II interferon production, nephric duct formation, nephric duct morphogenesis, nervous system development, neuron differentiation, neuron migration, norepinephrine biosynthetic process, otic vesicle development, parathyroid gland development, parathyroid hormone secretion, pharyngeal system development, phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of DNA-templated transcription, positive regulation of T cell differentiation, positive regulation of T-helper 2 cell cytokine production, positive regulation of cell differentiation, positive regulation of cytokine production, positive regulation of endothelial cell migration, positive regulation of gene expression, positive regulation of interleukin-13 production, positive regulation of interleukin-4 production, positive regulation of interleukin-5 production, positive regulation of miRNA transcription, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of signal transduction, positive regulation of thyroid hormone generation, positive regulation of transcription by RNA polymerase II, positive regulation of transcription regulatory region DNA binding, positive regulation of ureteric bud formation, post-embryonic development, pro-T cell differentiation, regulation of DNA-templated transcription, regulation of T-helper cell differentiation, regulation of cellular response to X-ray, regulation of cytokine production, regulation of developmental process, regulation of epithelial cell differentiation, regulation of establishment of cell polarity, regulation of multicellular organismal process, regulation of nephron tubule epithelial cell differentiation, regulation of neuron apoptotic process, regulation of neuron projection development, regulation of transcription by RNA polymerase II, response to estrogen, response to ethanol, response to gamma radiation, response to virus, response to xenobiotic stimulus, signal transduction, sympathetic nervous system development, thymic T cell selection, thymus development, type IV hypersensitivity, ureter maturation, ureter morphogenesis, ureteric bud formation, uterus development, ventricular septum development; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, E-box binding, HMG box domain binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, cis-regulatory region sequence-specific DNA binding, histone methyltransferase binding, identical protein binding, interleukin-2 receptor binding, metal ion binding, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding, transcription coactivator binding, zinc ion binding; CC: chromatin, nucleoplasm, nucleus
Pathways: Deubiquitination, ESR-mediated signaling, Estrogen-dependent gene expression, Factors involved in megakaryocyte development and platelet production, Gene expression (Transcription), Generic Transcription Pathway, Hemostasis, Inflammatory bowel disease - Mus musculus (mouse), Metabolism of proteins, Parathyroid hormone synthesis, secretion and action - Mus musculus (mouse), Post-translational protein modification, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Signal Transduction, Signaling by Nuclear Receptors, Th1 and Th2 cell differentiation - Mus musculus (mouse), Th17 cell differentiation - Mus musculus (mouse), Transcriptional regulation by RUNX1, Ub-specific processing proteases
UniProt: P23772
Entrez ID: 14462
|
Does Knockout of Krtap7-1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 82
|
Knockout
|
Krtap7-1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Krtap7-1 (keratin associated protein 7-1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, intermediate filament
Pathways:
UniProt: Q9D3I6
Entrez ID: 71363
|
Does Knockout of Pgap1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Pgap1
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Pgap1 (post-GPI attachment to proteins 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: GPI anchor biosynthetic process, anterior/posterior axis specification, embryonic pattern specification, forebrain regionalization, head development, positive regulation of ER to Golgi vesicle-mediated transport, protein transport, sensory perception of sound; MF: deacylase activity, hydrolase activity, hydrolase activity, acting on ester bonds, phosphatidylinositol deacylase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Attachment of GPI anchor to uPAR, Glycosylphosphatidylinositol (GPI)-anchor biosynthesis - Mus musculus (mouse), Metabolism of proteins, Post-translational modification: synthesis of GPI-anchored proteins, Post-translational protein modification
UniProt: Q3UUQ7
Entrez ID: 241062
|
Does Knockout of Poc1a in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,262
|
Knockout
|
Poc1a
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Poc1a (POC1 centriolar protein A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: bone development, cell projection organization, cilium assembly, growth plate cartilage chondrocyte development, mitotic spindle organization, non-motile cilium assembly, positive regulation of centrosome duplication, spermatogenesis; CC: cell projection, centriole, centrosome, ciliary basal body, cytoplasm, cytoskeleton, spindle pole
Pathways:
UniProt: Q8JZX3
Entrez ID: 70235
|
Does Knockout of Oxsr1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,264
|
Knockout
|
Oxsr1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Oxsr1 (oxidative-stress responsive 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell volume homeostasis, cellular hyperosmotic response, cellular hypotonic response, cellular response to chemokine, chemokine (C-C motif) ligand 21 signaling pathway, chemokine (C-X-C motif) ligand 12 signaling pathway, intracellular signal transduction, negative regulation of potassium ion transmembrane transport, osmosensory signaling pathway, positive regulation of T cell chemotaxis, potassium ion transmembrane transport, protein autophosphorylation, protein phosphorylation, renal sodium ion absorption, response to oxidative stress, response to xenobiotic stimulus, signal transduction; MF: ATP binding, identical protein binding, ion channel regulator activity, kinase activity, magnesium ion binding, metal ion binding, nucleotide binding, potassium channel inhibitor activity, protein binding, protein kinase activity, protein kinase binding, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity, transmembrane transporter binding; CC: cytoplasm, cytosol
Pathways:
UniProt: Q6P9R2
Entrez ID: 108737
|
Does Knockout of Fam32a in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 579
|
Knockout
|
Fam32a
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Fam32a (family with sequence similarity 32, member A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, biological_process; CC: nucleolus, nucleoplasm, nucleus
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q9CR80
Entrez ID: 67922
|
Does Knockout of Nlrp1a in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
Nlrp1a
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Nlrp1a (NLR family, pyrin domain containing 1A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: NLRP1 inflammasome complex assembly, activation of innate immune response, antiviral innate immune response, cellular response to UV-B, defense response, defense response to bacterium, defense response to virus, immune system process, inflammatory response, innate immune response, intrinsic apoptotic signaling pathway, negative regulation of cellular defense response, neuron apoptotic process, pattern recognition receptor signaling pathway, positive regulation of inflammatory response, positive regulation of interleukin-1 beta production, positive regulation of pyroptotic inflammatory response, programmed cell death, programmed necrotic cell death, protein homooligomerization, protein maturation, proteolysis, pyroptotic cell death, pyroptotic inflammatory response, regulation of apoptotic process, regulation of inflammatory response, response to muramyl dipeptide, self proteolysis, signal transduction; MF: ATP binding, ATP hydrolysis activity, cysteine-type endopeptidase activator activity, double-stranded DNA binding, double-stranded RNA binding, endopeptidase activity, enzyme binding, hydrolase activity, molecular condensate scaffold activity, nucleotide binding, pattern recognition receptor activity, peptidase activity, protein binding, protein domain specific binding, scaffold protein binding, signaling adaptor activity; CC: NLRP1 inflammasome complex, NLRP3 inflammasome complex, canonical inflammasome complex, cytoplasm, cytosol, neuronal cell body, nucleoplasm, nucleus, protein-containing complex
Pathways: Immune System, Inflammasomes, Innate Immune System, NOD-like receptor signaling pathway - Mus musculus (mouse), Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, The NLRP1 inflammasome
UniProt: Q2LKU9
Entrez ID: 195046
|
Does Knockout of Sult3a2 in Regulatory T cell causally result in cell proliferation?
| 0
| 2,127
|
Knockout
|
Sult3a2
|
cell proliferation
|
Regulatory T cell
|
Gene: Sult3a2 (sulfotransferase family 3A, member 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: sulfotransferase activity, transferase activity; CC: cytoplasm
Pathways:
UniProt: G5E904
Entrez ID: 215895
|
Does Knockout of Sae1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 2,307
|
Knockout
|
Sae1
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Sae1 (SUMO1 activating enzyme subunit 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of protein sumoylation, protein sumoylation; MF: ATP-dependent protein binding, SUMO activating enzyme activity, ligase activity, protein heterodimerization activity, small protein activating enzyme binding, ubiquitin-like modifier activating enzyme activity; CC: SUMO activating enzyme complex, cytoplasm, nucleoplasm, nucleus
Pathways: Metabolism of proteins, Post-translational protein modification, Processing and activation of SUMO, SUMO is conjugated to E1 (UBA2:SAE1), SUMO is transferred from E1 to E2 (UBE2I, UBC9), SUMOylation, Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: Q9R1T2
Entrez ID: 56459
|
Does Knockout of Rhox8 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Rhox8
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Rhox8 (reproductive homeobox 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of transcription by RNA polymerase II, regulation of gene expression, regulation of transcription by RNA polymerase II, spermatogenesis; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific; CC: nucleus
Pathways:
UniProt: Q6VSS7
Entrez ID: 434768
|
Does Knockout of Prrt1 in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Prrt1
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Prrt1 (proline-rich transmembrane protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intracellular protein localization, learning or memory, long-term synaptic depression, long-term synaptic potentiation, protein localization to cell surface, protein phosphorylation, regulation of AMPA receptor activity, synapse organization; MF: identical protein binding, signaling receptor regulator activity; CC: glutamatergic synapse, membrane, plasma membrane, postsynaptic density membrane, postsynaptic membrane, synapse, synaptic vesicle membrane
Pathways:
UniProt: O35449
Entrez ID: 260297
|
Does Knockout of Faap100 in Lymphoma Cell Line causally result in response to chemicals?
| 1
| 1,537
|
Knockout
|
Faap100
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Faap100 (Fanconi anemia core complex associated protein 100)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, interstrand cross-link repair; MF: DNA binding, molecular_function; CC: Fanconi anaemia nuclear complex, chromatin, cytosol, nucleoplasm, nucleus
Pathways: Antiviral mechanism by IFN-stimulated genes, Cytokine Signaling in Immune system, DNA Repair, Fanconi Anemia Pathway, Fanconi anemia pathway - Mus musculus (mouse), Immune System, Interferon Signaling, PKR-mediated signaling
UniProt: A2ACJ2
Entrez ID: 71885
|
Does Knockout of Insl3 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 161
|
Knockout
|
Insl3
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Insl3 (insulin-like 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway, in utero embryonic development, male gonad development, negative regulation of apoptotic process, negative regulation of cell population proliferation, oocyte maturation, positive regulation of cAMP/PKA signal transduction, positive regulation of cell population proliferation, positive regulation of epithelial cell migration, positive regulation of wound healing, regulation of male gonad development; MF: hormone activity, protease binding; CC: extracellular region, extracellular space, perinuclear region of cytoplasm
Pathways: Neuroactive ligand-receptor interaction - Mus musculus (mouse), Relaxin signaling pathway - Mus musculus (mouse)
UniProt: Q5RL10
Entrez ID: 16336
|
Does Knockout of Cdc42 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Cdc42
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Cdc42 (cell division cycle 42)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi organization, Rho protein signal transduction, actin cytoskeleton organization, actin filament branching, actin filament organization, adherens junction organization, anatomical structure morphogenesis, cardiac conduction system development, cardiac neural crest cell migration involved in outflow tract morphogenesis, cell differentiation, cell junction assembly, cell-cell adhesion, cellular response to type II interferon, dendritic cell migration, dendritic spine morphogenesis, embryonic heart tube development, endocytosis, endosomal transport, endothelin receptor signaling pathway involved in heart process, establishment of Golgi localization, establishment of cell polarity, establishment of epithelial cell apical/basal polarity, establishment of localization in cell, establishment or maintenance of apical/basal cell polarity, establishment or maintenance of cell polarity, filopodium assembly, heart contraction, heart process, host-mediated perturbation of viral process, integrin-mediated signaling pathway, intracellular protein localization, negative regulation of protein-containing complex assembly, nervous system development, neuron fate determination, neuropilin signaling pathway, nuclear migration, nucleus localization, organelle transport along microtubule, phagocytosis, engulfment, positive regulation of DNA replication, positive regulation of JNK cascade, positive regulation of MAPK cascade, positive regulation of cell growth, positive regulation of cell migration, positive regulation of cellular component organization, positive regulation of cytokinesis, positive regulation of epithelial cell proliferation involved in lung morphogenesis, positive regulation of filopodium assembly, positive regulation of intracellular protein transport, positive regulation of lamellipodium assembly, positive regulation of neuron apoptotic process, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of pinocytosis, positive regulation of pseudopodium assembly, positive regulation of stress fiber assembly, positive regulation of substrate adhesion-dependent cell spreading, positive regulation of synapse structural plasticity, regulation of actin cytoskeleton organization, regulation of attachment of spindle microtubules to kinetochore, regulation of filopodium assembly, regulation of lamellipodium assembly, regulation of mitotic nuclear division, regulation of modification of postsynaptic structure, regulation of postsynapse organization, regulation of stress fiber assembly, signal transduction, small GTPase-mediated signal transduction, sprouting angiogenesis; MF: G protein activity, GBD domain binding, GTP binding, GTP-dependent protein binding, GTPase activity, apolipoprotein A-I receptor binding, hydrolase activity, identical protein binding, mitogen-activated protein kinase kinase kinase binding, nucleotide binding, protein binding, protein kinase binding, thioesterase binding, ubiquitin protein ligase activity; CC: Golgi membrane, Golgi transport complex, Schaffer collateral - CA1 synapse, apical part of cell, cell leading edge, cell periphery, cell projection, cell-cell junction, centrosome, cytoplasm, cytoplasmic ribonucleoprotein granule, cytoskeleton, cytosol, dendrite, filopodium, glutamatergic synapse, lamellipodium membrane, leading edge membrane, membrane, midbody, mitotic spindle, myelin sheath, neuron projection, neuronal cell body, phagocytic vesicle, plasma membrane, postsynapse, protein-containing complex, secretory granule, spindle, spindle midzone, storage vacuole
Pathways: AGE-RAGE signaling pathway in diabetic complications - Mus musculus (mouse), Adaptive Immune System, Adherens junction - Mus musculus (mouse), Axon guidance, Axon guidance - Mus musculus (mouse), Bacterial invasion of epithelial cells - Mus musculus (mouse), CD28 dependent Vav1 pathway, CDC42 GTPase cycle, Chemokine signaling pathway - Mus musculus (mouse), Co-stimulation by CD28, DCC mediated attractive signaling, Developmental Biology, EGFR downregulation, EPH-Ephrin signaling, EPHB-mediated forward signaling, Endocytosis - Mus musculus (mouse), Factors involved in megakaryocyte development and platelet production, Fc gamma R-mediated phagocytosis - Mus musculus (mouse), Fcgamma receptor (FCGR) dependent phagocytosis, Focal adhesion - Mus musculus (mouse), G beta:gamma signalling through CDC42, G-protein beta:gamma signalling, GPCR downstream signalling, GPVI-mediated activation cascade, GnRH signaling pathway - Mus musculus (mouse), Hemostasis, Human papillomavirus infection - Mus musculus (mouse), Immune System, Innate Immune System, Leukocyte transendothelial migration - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), MAPK family signaling cascades, MAPK signaling pathway - Mus musculus (mouse), MAPK6/MAPK4 signaling, Myogenesis, Nervous system development, Netrin-1 signaling, Neurotrophin signaling pathway - Mus musculus (mouse), Non-alcoholic fatty liver disease - Mus musculus (mouse), Pancreatic cancer - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Platelet activation, signaling and aggregation, Proteoglycans in cancer - Mus musculus (mouse), RAC1 GTPase cycle, RAC2 GTPase cycle, RAC3 GTPase cycle, RHO GTPase Effectors, RHO GTPase cycle, RHO GTPases Activate Formins, RHO GTPases Activate WASPs and WAVEs, RHO GTPases activate IQGAPs, RHO GTPases activate KTN1, RHO GTPases activate PAKs, RHOG GTPase cycle, RHOQ GTPase cycle, RHOU GTPase cycle, RHOV GTPase cycle, Rap1 signaling pathway - Mus musculus (mouse), Ras signaling pathway - Mus musculus (mouse), Regulation of T cell activation by CD28 family, Regulation of actin cytoskeleton - Mus musculus (mouse), Regulation of actin dynamics for phagocytic cup formation, Renal cell carcinoma - Mus musculus (mouse), Salmonella infection - Mus musculus (mouse), Signal Transduction, Signaling by EGFR, Signaling by GPCR, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by VEGF, T cell receptor signaling pathway - Mus musculus (mouse), Tight junction - Mus musculus (mouse), VEGF signaling pathway - Mus musculus (mouse), VEGFA-VEGFR2 Pathway, Viral carcinogenesis - Mus musculus (mouse), Yersinia infection - Mus musculus (mouse)
UniProt: P60766
Entrez ID: 12540
|
Does Knockout of Padi4 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Padi4
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Padi4 (peptidyl arginine deiminase, type IV)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, chromatin remodeling, immune system process, innate immune response, nucleosome assembly, post-translational protein modification, stem cell population maintenance; MF: calcium ion binding, histone H3R17 arginine deiminase activity, histone H3R2 arginine deiminase activity, histone H3R26 arginine deiminase activity, histone H3R8 arginine deiminase activity, histone arginine deiminase activity, hydrolase activity, identical protein binding, metal ion binding, protein-arginine deiminase activity; CC: cytoplasm, nucleus, protein-containing complex
Pathways: Chromatin modifying enzymes, Chromatin organization, Neutrophil extracellular trap formation - Mus musculus (mouse), protein citrullination
UniProt: Q9Z183
Entrez ID: 18602
|
Does Knockout of Nde1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Nde1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Nde1 (nudE neurodevelopment protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, cell division, cell migration, centrosome duplication, centrosome localization, cerebral cortex development, chromosome localization, chromosome segregation, establishment of mitotic spindle orientation, forebrain development, microtubule nucleation, microtubule organizing center organization, mitotic centrosome separation, nervous system development, neuroblast proliferation, neuron migration, vesicle transport along microtubule; MF: identical protein binding, microtubule binding, protein binding, protein domain specific binding; CC: centrosome, chromosome, chromosome, centromeric region, cleavage furrow, cytoplasm, cytoplasmic vesicle, cytoplasmic vesicle membrane, cytoskeleton, kinesin complex, kinetochore, membrane, microtubule, microtubule organizing center, spindle, spindle pole centrosome, synapse
Pathways:
UniProt: Q9CZA6
Entrez ID: 67203
|
Does Knockout of Tmem165 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Tmem165
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Tmem165 (transmembrane protein 165)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi calcium ion homeostasis, Golgi calcium ion transport, calcium ion transmembrane transport, calcium ion transport, intracellular calcium ion homeostasis, manganese ion transmembrane transport, manganese ion transport, protein N-linked glycosylation, regulation of lysosomal lumen pH; MF: antiporter activity, calcium ion transmembrane transporter activity, manganese ion transmembrane transporter activity, metal ion transmembrane transporter activity; CC: Golgi apparatus, Golgi membrane, cis-Golgi network membrane, endosome membrane, lysosomal membrane, membrane, trans-Golgi network membrane
Pathways:
UniProt: P52875
Entrez ID: 21982
|
Does Knockout of Rdh7 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Rdh7
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Rdh7 (retinol dehydrogenase 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: retinol metabolic process, steroid metabolic process; MF: all-trans-retinol dehydrogenase (NAD+) activity, androstan-3-alpha,17-beta-diol dehydrogenase (NAD+) activity, androsterone dehydrogenase [NAD(P)+] activity, catalytic activity, oxidoreductase activity; CC: endoplasmic reticulum, intracellular membrane-bounded organelle
Pathways: Retinol metabolism - Mus musculus (mouse)
UniProt: O88451
Entrez ID: 54150
|
Does Knockout of Eif2ak2 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,174
|
Knockout
|
Eif2ak2
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Eif2ak2 (eukaryotic translation initiation factor 2-alpha kinase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: antiviral innate immune response, cellular response to amino acid starvation, defense response to virus, endoplasmic reticulum unfolded protein response, immune system process, innate immune response, negative regulation of apoptotic process, negative regulation of osteoblast proliferation, negative regulation of translation, negative regulation of viral genome replication, positive regulation of MAPK cascade, positive regulation of NF-kappaB transcription factor activity, positive regulation of apoptotic process, positive regulation of chemokine production, positive regulation of cytokine production, positive regulation of non-canonical NF-kappaB signal transduction, positive regulation of stress-activated MAPK cascade, protein autophosphorylation, regulation of NLRP3 inflammasome complex assembly, regulation of hematopoietic progenitor cell differentiation, regulation of hematopoietic stem cell differentiation, regulation of hematopoietic stem cell proliferation, regulation of translational initiation, response to interferon-alpha, response to lipopolysaccharide, response to toxic substance, response to virus, response to vitamin E, translation, translational initiation; MF: ATP binding, RNA binding, double-stranded RNA binding, eukaryotic translation initiation factor 2alpha kinase activity, identical protein binding, kinase activity, non-membrane spanning protein tyrosine kinase activity, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, protein tyrosine kinase activity, transferase activity; CC: cytoplasm, cytosol, nucleus, perinuclear region of cytoplasm
Pathways: Alzheimer disease - Mus musculus (mouse), Antiviral mechanism by IFN-stimulated genes, Coronavirus disease - COVID-19 - Mus musculus (mouse), Cytokine Signaling in Immune system, Epstein-Barr virus infection - Mus musculus (mouse), Hepatitis C - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), ISG15 antiviral mechanism, Immune System, Influenza A - Mus musculus (mouse), Interferon Signaling, Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Measles - Mus musculus (mouse), Necroptosis - Mus musculus (mouse), PKR-mediated signaling, Protein processing in endoplasmic reticulum - Mus musculus (mouse), Viral carcinogenesis - Mus musculus (mouse)
UniProt: Q03963
Entrez ID: 19106
|
Does Knockout of Tmed5 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
Tmed5
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Tmed5 (transmembrane p24 trafficking protein 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi ribbon formation, endoplasmic reticulum to Golgi vesicle-mediated transport, intracellular protein transport, protein transport; CC: COPII-coated ER to Golgi transport vesicle, Golgi apparatus, cis-Golgi network, endoplasmic reticulum, endoplasmic reticulum exit site, endoplasmic reticulum membrane, endoplasmic reticulum-Golgi intermediate compartment, endoplasmic reticulum-Golgi intermediate compartment membrane, membrane
Pathways: Signal Transduction, Signaling by WNT, WNT ligand biogenesis and trafficking
UniProt: Q9CXE7
Entrez ID: 73130
|
Does Knockout of Pgs1 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 1
| 2,172
|
Knockout
|
Pgs1
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Pgs1 (phosphatidylglycerophosphate synthase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cardiolipin biosynthetic process, diacylglycerol metabolic process, lipid metabolic process, phosphatidylglycerol biosynthetic process, phospholipid biosynthetic process; MF: ATP binding, CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity, catalytic activity, hydrolase activity, acting on ester bonds, nucleotide binding, transferase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, mitochondrial inner membrane, mitochondrion
Pathways: Glycerophospholipid metabolism - Mus musculus (mouse), cardiolipin biosynthesis I, cardiolipin biosynthesis II, phosphatidylglycerol biosynthesis I (plastidic), phosphatidylglycerol biosynthesis II (non-plastidic), phospholipid biosynthesis I
UniProt: Q8BHF7
Entrez ID: 74451
|
Does Knockout of Rala in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Rala
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Rala (v-ral simian leukemia viral oncogene A (ras related))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Ras protein signal transduction, cell division, establishment of protein localization to mitochondrion, exocytosis, membrane raft localization, neural tube closure, positive regulation of epidermal growth factor receptor signaling pathway, positive regulation of filopodium assembly, positive regulation of mitochondrial fission, receptor internalization, regulation of actin cytoskeleton organization, regulation of exocytosis, regulation of postsynaptic neurotransmitter receptor internalization, signal transduction; MF: ATPase binding, Edg-2 lysophosphatidic acid receptor binding, G protein activity, GDP binding, GTP binding, GTPase activity, hydrolase activity, myosin binding, nucleotide binding, protein binding, ubiquitin protein ligase binding; CC: Flemming body, Schaffer collateral - CA1 synapse, cell surface, cleavage furrow, cytoplasmic vesicle membrane, endocytic vesicle, focal adhesion, membrane, mitochondrion, myelin sheath, plasma membrane, synaptic membrane
Pathways: Colorectal cancer - Mus musculus (mouse), Pancreatic cancer - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Phospholipase D signaling pathway - Mus musculus (mouse), Rap1 signaling pathway - Mus musculus (mouse), Ras signaling pathway - Mus musculus (mouse), Salmonella infection - Mus musculus (mouse)
UniProt: P63321
Entrez ID: 56044
|
Does Knockout of Cd101 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Cd101
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Cd101 (CD101 antigen)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: membrane
Pathways: Adaptive Immune System, Generation of second messenger molecules, Immune System, TCR signaling
UniProt: A8E0Y8
Entrez ID: 630146
|
Does Knockout of Pdcd5 in Acute Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 684
|
Knockout
|
Pdcd5
|
cell proliferation
|
Acute Myeloid Leukemia Cell Line
|
Gene: Pdcd5 (programmed cell death 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, cellular response to transforming growth factor beta stimulus, negative regulation of protein folding, positive regulation of apoptotic process, positive regulation of gene expression, regulation of apoptotic process; MF: DNA binding, acetyltransferase activator activity, beta-tubulin binding, heparin binding; CC: cytoplasm, cytosol, nucleus
Pathways:
UniProt: P56812
Entrez ID: 56330
|
Does Knockout of Fntb in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Fntb
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Fntb (farnesyltransferase, CAAX box, beta)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: lipid metabolic process, negative regulation of cell population proliferation, positive regulation of cell cycle, positive regulation of cell population proliferation, positive regulation of fibroblast proliferation, protein farnesylation, regulation of fibroblast proliferation, wound healing; MF: acetyltransferase activator activity, catalytic activity, enzyme binding, geranylgeranyl diphosphate synthase activity, metal ion binding, peptide binding, prenyltransferase activity, protein farnesyltransferase activity, protein prenyltransferase activity, transferase activity, zinc ion binding; CC: microtubule associated complex, protein farnesyltransferase complex
Pathways: Inactivation, recovery and regulation of the phototransduction cascade, MAPK family signaling cascades, MAPK1/MAPK3 signaling, RAF/MAP kinase cascade, RAS processing, Sensory Perception, Signal Transduction, Terpenoid backbone biosynthesis - Mus musculus (mouse), The phototransduction cascade, Visual phototransduction
UniProt: Q8K2I1
Entrez ID: 110606
|
Does Knockout of Snrnp70 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Snrnp70
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Snrnp70 (small nuclear ribonucleoprotein 70 (U1))
Type: protein-coding
Summary: This gene encodes a subunit of the U1 snRNP (small nuclear ribonucleic particle), one of at least five snRNPs to comprise the spliceosome, which functions in processing of pre-mRNAs. The U1 snRNP has been shown to be important in defining the 5' splice site. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014].
Gene Ontology: BP: cellular response to retinoic acid, cellular response to transforming growth factor beta stimulus, cellular response to tumor necrosis factor, mRNA splicing, via spliceosome, negative regulation of chaperone-mediated autophagy, negative regulation of protein refolding, positive regulation of mRNA splicing, via spliceosome, regulation of RNA splicing; MF: RNA binding, U1 snRNA binding, U1 snRNP binding, mRNA binding, nucleic acid binding; CC: U1 snRNP, U2-type prespliceosome, lysosomal lumen, nuclear speck, nucleoplasm, nucleus, ribonucleoprotein complex, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q62376
Entrez ID: 20637
|
Does Knockout of Pus3 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Pus3
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Pus3 (pseudouridine synthase 3)
Type: protein-coding
Summary: Enables pseudouridine synthase activity. Acts upstream of or within tRNA pseudouridine synthesis. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; heart ventricle; pharyngo-tympanic tube; pituitary gland; and vertebral axis musculature. Orthologous to human PUS3 (pseudouridine synthase 3). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: RNA modification, mRNA pseudouridine synthesis, pseudouridine synthesis, tRNA processing, tRNA pseudouridine synthesis; MF: RNA binding, isomerase activity, pseudouridine synthase activity, tRNA pseudouridine(38/39) synthase activity; CC: cytoplasm, nucleus
Pathways:
UniProt: Q9JI38
Entrez ID: 67049
|
Does Knockout of Ola1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,267
|
Knockout
|
Ola1
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Ola1 (Obg-like ATPase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ATP metabolic process; MF: ATP binding, ATP hydrolysis activity, GTP binding, hydrolase activity, metal ion binding, nucleotide binding, ribosomal large subunit binding, ribosome binding; CC: centrosome, cytoplasm, cytosol, nucleolus, nucleus
Pathways: Hemostasis, Platelet activation, signaling and aggregation, Platelet degranulation , Response to elevated platelet cytosolic Ca2+
UniProt: Q9CZ30
Entrez ID: 67059
|
Does Knockout of Brd2 in Acute Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 684
|
Knockout
|
Brd2
|
cell proliferation
|
Acute Myeloid Leukemia Cell Line
|
Gene: Brd2 (bromodomain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell surface receptor signaling pathway via JAK-STAT, chromatin looping, chromatin organization, chromatin remodeling, neural tube closure, nucleosome assembly, positive regulation of T-helper 17 cell lineage commitment, protein localization to chromatin, regulation of DNA-templated transcription, regulation of gene expression, regulation of transcription by RNA polymerase II; MF: acetylation-dependent protein binding, histone H3K14ac reader activity, histone H4K12ac reader activity, histone H4K5ac reader activity, histone reader activity, protein serine/threonine kinase activity; CC: chromatin, chromosome, cytoplasm, nuclear speck, nucleoplasm, nucleus
Pathways:
UniProt: Q7JJ13
Entrez ID: 14312
|
Does Knockout of Vasn in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Vasn
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Vasn (vasorin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to hypoxia, cellular response to redox state, negative regulation of epithelial to mesenchymal transition, negative regulation of transforming growth factor beta receptor signaling pathway; MF: protein binding, signaling receptor activity, transforming growth factor beta binding; CC: cell surface, extracellular exosome, extracellular space, membrane, mitochondrion, plasma membrane
Pathways:
UniProt: Q9CZT5
Entrez ID: 246154
|
Does Knockout of Dynlt1a in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 165
|
Knockout
|
Dynlt1a
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Dynlt1a (dynein light chain Tctex-type 1A)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways: Immune System, Innate Immune System, Neutrophil degranulation, Salmonella infection - Mus musculus (mouse)
UniProt: P51807
Entrez ID: 100310872
|
Does Knockout of Ypel5 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Ypel5
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Ypel5 (yippee like 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, cell population proliferation; MF: metal ion binding, molecular_function; CC: centrosome, cytoplasm, cytoskeleton, midbody, mitotic spindle pole, nucleus, spindle pole, ubiquitin ligase complex
Pathways: Immune System, Innate Immune System, Neutrophil degranulation
UniProt: P62700
Entrez ID: 383295
|
Does Knockout of Zbtb8os in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,265
|
Knockout
|
Zbtb8os
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Zbtb8os (zinc finger and BTB domain containing 8 opposite strand)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: tRNA processing, tRNA splicing, via endonucleolytic cleavage and ligation; MF: metal ion binding, molecular_function; CC: tRNA-splicing ligase complex
Pathways:
UniProt: Q505B7
Entrez ID: 67106
|
Does Knockout of Slc17a8 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Slc17a8
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Slc17a8 (solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: L-glutamate import, L-glutamate transmembrane transport, chloride transmembrane transport, chloride transport, cochlea development, monoatomic ion transmembrane transport, monoatomic ion transport, neural retina development, neurotransmitter loading into synaptic vesicle, neurotransmitter transport, phosphate ion homeostasis, phosphate ion transport, positive regulation of glutamate uptake involved in transmission of nerve impulse, regulation of acetylcholine uptake, regulation of synapse structure or activity, sensory perception of sound, sodium ion transmembrane transport, sodium ion transport, sodium-dependent phosphate transport, synaptic transmission, glutamatergic, transmembrane transport; MF: L-glutamate transmembrane transporter activity, L-glutamate uniporter activity, chloride channel activity, neurotransmitter transmembrane transporter activity, sodium:phosphate symporter activity, symporter activity, transmembrane transporter activity; CC: apical dendrite, axon terminus, basal dendrite, chloride channel complex, clathrin-sculpted glutamate transport vesicle membrane, cytoplasmic vesicle, dendrite, excitatory synapse, glial limiting end-foot, glutamatergic synapse, membrane, multivesicular body, neuron projection, neuronal cell body, pericellular basket, perikaryon, plasma membrane, synapse, synaptic vesicle, synaptic vesicle membrane
Pathways: Glutamatergic synapse - Mus musculus (mouse), Nicotine addiction - Mus musculus (mouse), Retrograde endocannabinoid signaling - Mus musculus (mouse), SLC-mediated transmembrane transport, SLC-mediated transport of neurotransmitters, Synaptic vesicle cycle - Mus musculus (mouse), Transport of small molecules
UniProt: Q8BFU8
Entrez ID: 216227
|
Does Knockout of Reg3d in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 83
|
Knockout
|
Reg3d
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Reg3d (regenerating islet-derived 3 delta)
Type: protein-coding
Summary: Predicted to enable oligosaccharide binding activity; peptidoglycan binding activity; and signaling receptor activity. Predicted to be involved in antimicrobial humoral immune response mediated by antimicrobial peptide; positive regulation of cell population proliferation; and response to peptide hormone. Predicted to be active in extracellular space. Orthologous to human REG3A (regenerating family member 3 alpha) and REG3G (regenerating family member 3 gamma). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: antimicrobial humoral immune response mediated by antimicrobial peptide, positive regulation of cell population proliferation, response to peptide hormone; MF: carbohydrate binding, hormone activity, identical protein binding, oligosaccharide binding, peptidoglycan binding, signaling receptor activity; CC: extracellular region, extracellular space
Pathways: Antimicrobial peptides, Immune System, Innate Immune System
UniProt: Q9QUS9, G3UWG6
Entrez ID: 30053
|
Does Knockout of Tmem145 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Tmem145
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Tmem145 (transmembrane protein 145)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, biological_process, response to pheromone; CC: cellular_component, membrane
Pathways:
UniProt: Q8C4U2
Entrez ID: 330485
|
Does Knockout of Nfkbie in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,290
|
Knockout
|
Nfkbie
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Nfkbie (nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, epsilon)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: D-serine transmembrane transport, negative regulation of DNA-templated transcription; MF: protein binding, protein sequestering activity; CC: cytoplasm, cytosol, fibrillar center, nucleoplasm, perinuclear region of cytoplasm
Pathways: Adipocytokine signaling pathway - Mus musculus (mouse), B cell receptor signaling pathway - Mus musculus (mouse), Epstein-Barr virus infection - Mus musculus (mouse), Neurotrophin signaling pathway - Mus musculus (mouse), PD-L1 expression and PD-1 checkpoint pathway in cancer - Mus musculus (mouse), T cell receptor signaling pathway - Mus musculus (mouse), Th1 and Th2 cell differentiation - Mus musculus (mouse), Th17 cell differentiation - Mus musculus (mouse)
UniProt: O54910
Entrez ID: 18037
|
Does Knockout of Zfp735 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Zfp735
|
phagocytosis
|
macrophage
|
Gene: Zfp735 (zinc finger protein 735)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: metal ion binding, zinc ion binding; CC: nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Mus musculus (mouse), RNA Polymerase II Transcription
UniProt: B1ARH2, B2RQK9
Entrez ID: 76390
|
Does Knockout of Ncoa5 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 2,307
|
Knockout
|
Ncoa5
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Ncoa5 (nuclear receptor coactivator 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: glucose homeostasis, negative regulation of insulin receptor signaling pathway, regulation of signal transduction; CC: actin cytoskeleton, nucleoplasm, nucleus
Pathways:
UniProt: Q91W39
Entrez ID: 228869
|
Does Knockout of Hmgn2 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Hmgn2
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Hmgn2 (high mobility group nucleosomal binding domain 2)
Type: protein-coding
Summary: Predicted to enable chromatin binding activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II and regulation of development, heterochronic. Located in female germ cell nucleus. Is expressed in several structures, including brain; eye; genitourinary system; heart; and lung. Used to study Axenfeld-Rieger syndrome type 1. Orthologous to human HMGN2 (high mobility group nucleosomal binding domain 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: antimicrobial humoral immune response mediated by antimicrobial peptide, chromatin organization, killing of cells of another organism, negative regulation of transcription by RNA polymerase II, regulation of development, heterochronic, regulation of transcription by RNA polymerase II; MF: DNA binding, chromatin binding, nucleosomal DNA binding; CC: chromatin, cytoplasm, extracellular space, female germ cell nucleus, nucleus
Pathways:
UniProt: P09602
Entrez ID: 15331
|
Does Knockout of N6amt1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
N6amt1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: N6amt1 (N-6 adenine-specific DNA methyltransferase 1 (putative))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: arsonoacetate metabolic process, chromatin organization, methylation, negative regulation of gene expression, epigenetic, peptidyl-glutamine methylation, positive regulation of cell growth, toxin metabolic process, transcription initiation-coupled chromatin remodeling; MF: S-adenosyl-L-methionine binding, S-adenosylmethionine-dependent methyltransferase activity, arsenite methyltransferase activity, histone H4K12 methyltransferase activity, histone methyltransferase activity, methyltransferase activity, nucleic acid binding, protein binding, protein methyltransferase activity, protein-glutamine N-methyltransferase activity, site-specific DNA-methyltransferase (adenine-specific) activity, transferase activity; CC: eRF1 methyltransferase complex, nucleus, protein-containing complex
Pathways: Biological oxidations, Eukaryotic Translation Termination, Metabolism, Metabolism of proteins, Methylation, Phase II - Conjugation of compounds, Translation
UniProt: Q6SKR2
Entrez ID: 67768
|
Does Knockout of Ezh2 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 1,130
|
Knockout
|
Ezh2
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Ezh2 (enhancer of zeste 2 polycomb repressive complex 2 subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell differentiation, DNA methylation-dependent constitutive heterochromatin formation, G1 to G0 transition, cardiac muscle hypertrophy in response to stress, cellular response to hydrogen peroxide, cellular response to trichostatin A, cerebellar cortex development, chromatin organization, chromatin remodeling, constitutive heterochromatin formation, facultative heterochromatin formation, hemopoiesis, hepatocyte homeostasis, heterochromatin formation, hippocampus development, immunoglobulin heavy chain V-D-J recombination, liver regeneration, methylation, negative regulation of DNA-templated transcription, negative regulation of G1/S transition of mitotic cell cycle, negative regulation of cytokine production involved in inflammatory response, negative regulation of epidermal cell differentiation, negative regulation of gene expression, negative regulation of gene expression, epigenetic, negative regulation of keratinocyte differentiation, negative regulation of retinoic acid receptor signaling pathway, negative regulation of stem cell differentiation, negative regulation of striated muscle cell differentiation, negative regulation of transcription by RNA polymerase II, negative regulation of transcription elongation by RNA polymerase II, positive regulation of GTPase activity, positive regulation of MAP kinase activity, positive regulation of cell cycle G1/S phase transition, positive regulation of cell migration, positive regulation of cell population proliferation, positive regulation of dendrite development, positive regulation of epithelial to mesenchymal transition, positive regulation of protein serine/threonine kinase activity, protein localization to chromatin, regulation of cell population proliferation, regulation of circadian rhythm, regulation of gene expression, regulation of gliogenesis, regulation of kidney development, regulation of neurogenesis, regulation of transcription by RNA polymerase II, regulatory ncRNA-mediated heterochromatin formation, response to estradiol, response to tetrachloromethane, rhythmic process, skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration, subtelomeric heterochromatin formation, synaptic transmission, GABAergic; MF: DNA binding, RNA binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II core promoter sequence-specific DNA binding, chromatin DNA binding, chromatin binding, histone H3K27 methyltransferase activity, histone H3K27 trimethyltransferase activity, histone binding, histone methyltransferase activity, lncRNA binding, methyltransferase activity, nucleosome binding, primary miRNA binding, promoter-specific chromatin binding, protein binding, protein-lysine N-methyltransferase activity, ribonucleoprotein complex binding, sequence-specific DNA binding, transcription cis-regulatory region binding, transcription corepressor activity, transcription corepressor binding, transferase activity; CC: ESC/E(Z) complex, chromatin, chromatin silencing complex, chromosomal region, chromosome, chromosome, telomeric region, heterochromatin, nucleoplasm, nucleus, pericentric heterochromatin, pronucleus, synapse
Pathways: Lysine degradation - Mus musculus (mouse), MicroRNAs in cancer - Mus musculus (mouse)
UniProt: Q61188
Entrez ID: 14056
|
Does Knockout of Otof in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Otof
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Otof (otoferlin)
Type: protein-coding
Summary: Enables AP-2 adaptor complex binding activity and calcium ion binding activity. Involved in synaptic vesicle priming. Located in endoplasmic reticulum and presynaptic active zone membrane. Is active in cochlear hair cell ribbon synapse and synaptic vesicle membrane. Is expressed in brain; pons mantle layer; and rest of cerebellum ventricular layer. Used to study autosomal recessive nonsyndromic deafness 9. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 9. Orthologous to human OTOF (otoferlin). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: plasma membrane organization, sensory perception of sound, startle response, synaptic vesicle exocytosis, synaptic vesicle priming, synaptic vesicle recycling; MF: AP-2 adaptor complex binding, calcium ion binding, metal ion binding, protein binding, protein-containing complex binding; CC: Golgi apparatus, Golgi membrane, apical part of cell, basal part of cell, basolateral plasma membrane, cell projection, clathrin-sculpted glutamate transport vesicle membrane, cochlear hair cell ribbon synapse, cytoplasmic vesicle, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, plasma membrane, presynaptic active zone membrane, presynaptic membrane, synapse, synaptic vesicle membrane, trans-Golgi network
Pathways:
UniProt: Q9ESF1
Entrez ID: 83762
|
Does Knockout of Ythdf1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,290
|
Knockout
|
Ythdf1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Ythdf1 (YTH N6-methyladenosine RNA binding protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: immune system process, learning, mRNA destabilization, memory, organelle assembly, positive regulation of translation, positive regulation of translational initiation, regulation of antigen processing and presentation, regulation of axon guidance, regulation of long-term synaptic potentiation, regulation of mRNA stability, stress granule assembly; MF: N6-methyladenosine-containing RNA reader activity, RNA binding, mRNA binding, ribosome binding; CC: P-body, cytoplasm, cytoplasmic stress granule
Pathways:
UniProt: P59326
Entrez ID: 228994
|
Does Knockout of Fpr2 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Fpr2
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Fpr2 (formyl peptide receptor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway, astrocyte activation, calcium-mediated signaling, cell surface receptor signaling pathway, cellular response to amyloid-beta, chemotaxis, complement receptor mediated signaling pathway, defense response to bacterium, immune response-regulating cell surface receptor signaling pathway, inflammatory response, microglial cell activation, negative regulation of inflammatory response, negative regulation of neuron apoptotic process, phospholipase C-activating G protein-coupled receptor signaling pathway, positive chemotaxis, positive regulation of ERK1 and ERK2 cascade, positive regulation of cytosolic calcium ion concentration, positive regulation of innate immune response, positive regulation of monocyte chemotaxis, positive regulation of phagocytosis, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of superoxide anion generation, receptor-mediated endocytosis, signal transduction; MF: G protein-coupled receptor activity, N-formyl peptide receptor activity, RAGE receptor binding, amyloid-beta binding, cargo receptor activity, complement receptor activity, scavenger receptor binding, signaling receptor activity; CC: cytoplasm, membrane, plasma membrane
Pathways: Class A/1 (Rhodopsin-like receptors), Formyl peptide receptors bind formyl peptides and many other ligands, G alpha (i) signalling events, G alpha (q) signalling events, GPCR downstream signalling, GPCR ligand binding, Immune System, Innate Immune System, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Neutrophil degranulation, Neutrophil extracellular trap formation - Mus musculus (mouse), Peptide ligand-binding receptors, Signal Transduction, Signaling by GPCR, Staphylococcus aureus infection - Mus musculus (mouse)
UniProt: O88536
Entrez ID: 14289
|
Does Knockout of Zzef1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Zzef1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Zzef1 (zinc finger, ZZ-type with EF hand domain 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: neuroblast proliferation, protein ubiquitination, regulation of synaptic plasticity, synaptic transmission, glutamatergic, visual learning; MF: calcium ion binding, histone binding, metal ion binding, ubiquitin-like protein ligase activity, zinc ion binding; CC: cell surface, postsynapse, presynaptic active zone, synapse
Pathways:
UniProt: Q5SSH7
Entrez ID: 195018
|
Does Knockout of Kcnh5 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Kcnh5
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Kcnh5 (potassium voltage-gated channel, subfamily H (eag-related), member 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: monoatomic ion transmembrane transport, monoatomic ion transport, potassium ion transmembrane transport, potassium ion transport, regulation of G2/M transition of mitotic cell cycle, regulation of membrane potential, transmembrane transport; MF: calmodulin binding, delayed rectifier potassium channel activity, monoatomic ion channel activity, potassium channel activity, protein-containing complex binding, transmembrane transporter binding, voltage-gated potassium channel activity; CC: cell surface, membrane, monoatomic ion channel complex, plasma membrane, voltage-gated potassium channel complex
Pathways: Neuronal System, Potassium Channels, Voltage gated Potassium channels
UniProt: Q920E3
Entrez ID: 238271
|
Does Knockout of Paip2b in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Paip2b
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Paip2b (poly(A) binding protein interacting protein 2B)
Type: protein-coding
Summary: Predicted to enable mRNA regulatory element binding translation repressor activity and poly(A) binding activity. Predicted to be involved in negative regulation of translational initiation. Predicted to be active in cytoplasm. Is expressed in embryo. Orthologous to human PAIP2B (poly(A) binding protein interacting protein 2B). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: negative regulation of translation, negative regulation of translational initiation, regulation of translation; MF: mRNA regulatory element binding translation repressor activity, poly(A) binding, translation repressor activity
Pathways:
UniProt: Q91W45
Entrez ID: 232164
|
Does Knockout of Lonrf2 in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Lonrf2
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Lonrf2 (LON peptidase N-terminal domain and ring finger 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: motor behavior, negative regulation of neuron apoptotic process, neuromuscular process, neuron apoptotic process, neuron projection development, protein quality control for misfolded or incompletely synthesized proteins, protein ubiquitination, response to sodium arsenite, spinal cord motor neuron differentiation; MF: metal ion binding, misfolded protein binding, protein binding, ribonucleoprotein complex binding, ubiquitin protein ligase activity, zinc ion binding; CC: cellular_component, cytoplasm
Pathways:
UniProt: F6ZE64, B2RT44
Entrez ID: 381338
|
Does Knockout of Atxn1l in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 2,173
|
Knockout
|
Atxn1l
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Atxn1l (ataxin 1-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: brain development, extracellular matrix organization, learning, lung alveolus development, memory, negative regulation of transcription by RNA polymerase II, positive regulation of hematopoietic stem cell proliferation, regulation of DNA-templated transcription, social behavior; MF: DNA binding, POZ domain binding, RNA binding, chromatin binding, protein binding; CC: cell projection, dendrite, nucleolus, nucleoplasm, nucleus
Pathways: Notch signaling pathway - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Spinocerebellar ataxia - Mus musculus (mouse)
UniProt: P0C7T6
Entrez ID: 52335
|
Does Knockout of Gatb in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,264
|
Knockout
|
Gatb
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Gatb (glutamyl-tRNA amidotransferase subunit B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: glutaminyl-tRNAGln biosynthesis via transamidation, mitochondrial translation, translation; MF: ATP binding, carbon-nitrogen ligase activity, with glutamine as amido-N-donor, catalytic activity, glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity, ligase activity, nucleotide binding; CC: glutamyl-tRNA(Gln) amidotransferase complex, mitochondrion
Pathways: Aminoacyl-tRNA biosynthesis - Mus musculus (mouse)
UniProt: Q99JT1
Entrez ID: 229487
|
Does Knockout of Acd in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Acd
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Acd (adrenocortical dysplasia)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: embryonic limb morphogenesis, establishment of protein localization to telomere, intracellular protein transport, negative regulation of telomere maintenance via telomerase, positive regulation of telomere maintenance, protection from non-homologous end joining at telomere, protein localization to chromosome, telomeric region, regulation of establishment of protein localization to telomere, segmentation, skeletal system development, telomere assembly, telomere capping, telomere maintenance, telomere maintenance via telomerase, urogenital system development; MF: DNA binding, DNA polymerase binding, protein binding, protein-containing complex binding, telomerase inhibitor activity, telomeric DNA binding; CC: chromosome, chromosome, telomeric region, nuclear body, nuclear telomere cap complex, nucleoplasm, nucleus, shelterin complex, telomerase holoenzyme complex
Pathways: Base Excision Repair, Base-Excision Repair, AP Site Formation, Cell Cycle, Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, Chromosome Maintenance, Cleavage of the damaged purine, DNA Damage/Telomere Stress Induced Senescence, DNA Repair, Depurination, Extension of Telomeres, Inhibition of DNA recombination at telomere, Polymerase switching on the C-strand of the telomere, Processive synthesis on the C-strand of the telomere, Recognition and association of DNA glycosylase with site containing an affected purine, Removal of the Flap Intermediate from the C-strand, Telomere C-strand (Lagging Strand) Synthesis, Telomere C-strand synthesis initiation, Telomere Extension By Telomerase, Telomere Maintenance
UniProt: Q5EE38
Entrez ID: 497652
|
Does Knockout of Gemin6 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Gemin6
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Gemin6 (gem nuclear organelle associated protein 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, mRNA processing, spliceosomal complex assembly, spliceosomal snRNP assembly; MF: RNA binding, protein binding; CC: Gemini of Cajal bodies, SMN complex, SMN-Sm protein complex, cytoplasm, cytosol, nuclear body, nucleoplasm, nucleus
Pathways: Metabolism of RNA, Metabolism of non-coding RNA, snRNP Assembly
UniProt: Q9CX53
Entrez ID: 67242
|
Does Knockout of Tmem225 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Tmem225
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Tmem225 (transmembrane protein 225)
Type: protein-coding
Summary: Enables protein phosphatase 1 binding activity and protein phosphatase inhibitor activity. Involved in negative regulation of phosphatase activity. Located in inner acrosomal membrane and outer acrosomal membrane. Orthologous to human TMEM225 (transmembrane protein 225). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: MF: protein phosphatase 1 binding, protein phosphatase inhibitor activity; CC: acrosomal membrane, cytoplasmic vesicle, inner acrosomal membrane, membrane, outer acrosomal membrane
Pathways:
UniProt: Q9D9S2
Entrez ID: 75667
|
Does Knockout of Rnf2 in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Rnf2
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Rnf2 (ring finger protein 2)
Type: protein-coding
Summary: Enables chromatin binding activity and histone H2AK119 ubiquitin ligase activity. Involved in germ cell development and negative regulation of transcription by RNA polymerase II. Acts upstream of or within with a positive effect on chromatin organization. Acts upstream of or within with a negative effect on gene expression. Acts upstream of or within anterior/posterior axis specification; gastrulation with mouth forming second; and mitotic cell cycle. Located in euchromatin; nuclear body; and sex chromatin. Part of PRC1 complex. Is active in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; early embryo; genitourinary system; limb; and retina. Human ortholog(s) of this gene implicated in Luo-Schoch-Yamamoto syndrome. Orthologous to human RNF2 (ring finger protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: anterior/posterior axis specification, chromatin organization, chromatin remodeling, epigenetic regulation of gene expression, gastrulation with mouth forming second, gene expression, germ cell development, mitotic cell cycle, negative regulation of transcription by RNA polymerase II, protein ubiquitination; MF: RING-like zinc finger domain binding, chromatin binding, histone H2AK119 ubiquitin ligase activity, metal ion binding, protein binding, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: MLL1 complex, PRC1 complex, PcG protein complex, chromosome, cytoplasm, euchromatin, heterochromatin, nuclear body, nucleoplasm, nucleus, sex chromatin, ubiquitin ligase complex
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Metabolism of proteins, Post-translational protein modification, RNA Polymerase II Transcription, RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, SUMOylation of RNA binding proteins, SUMOylation of chromatin organization proteins, SUMOylation of transcription cofactors, Transcriptional Regulation by E2F6, Transcriptional regulation by RUNX1
UniProt: Q9CQJ4
Entrez ID: 19821
|
Does Knockout of Cd8a in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
Cd8a
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Cd8a (CD8 subunit alpha)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell activation, T cell mediated immunity, T cell receptor signaling pathway, adaptive immune response, cell surface receptor signaling pathway, cytotoxic T cell differentiation, defense response to virus, immune system process, positive regulation of calcium-mediated signaling; MF: MHC class I protein complex binding, identical protein binding, protein binding, protein kinase binding; CC: cell surface, external side of plasma membrane, membrane, plasma membrane, plasma membrane raft, receptor complex
Pathways: Adaptive Immune System, Antigen processing and presentation - Mus musculus (mouse), Cell adhesion molecules - Mus musculus (mouse), Hematopoietic cell lineage - Mus musculus (mouse), Immune System, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, Primary immunodeficiency - Mus musculus (mouse), T cell receptor signaling pathway - Mus musculus (mouse), Yersinia infection - Mus musculus (mouse)
UniProt: P01731
Entrez ID: 12525
|
Does Knockout of Lrrn2 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Lrrn2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Lrrn2 (leucine rich repeat protein 2, neuronal)
Type: protein-coding
Summary: Predicted to be active in extracellular matrix and extracellular space. Is expressed in several structures, including adrenal medulla; gut; nervous system; optic cup; and urinary system. Orthologous to human LRRN2 (leucine rich repeat neuronal 2). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: MF: molecular_function, signaling receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: Q6PHP6
Entrez ID: 16980
|
Does Knockout of Cinp in Lymphoma Cell Line causally result in response to chemicals?
| 1
| 1,530
|
Knockout
|
Cinp
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Cinp (cyclin dependent kinase 2 interacting protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, DNA replication, biological_process, cell division, ribosomal large subunit biogenesis, ribosome biogenesis; MF: molecular_function, preribosome binding; CC: cellular_component, nucleus
Pathways:
UniProt: Q9D0V8
Entrez ID: 67236
|
Does Knockout of Mcts1 in Acute Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 684
|
Knockout
|
Mcts1
|
cell proliferation
|
Acute Myeloid Leukemia Cell Line
|
Gene: Mcts1 (malignant T cell amplified sequence 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, IRES-dependent viral translational initiation, formation of translation preinitiation complex, ribosome disassembly, translation, translation reinitiation, translational initiation; MF: RNA binding, RNA cap binding, ribosomal small subunit binding, translation initiation factor activity; CC: cytoplasm
Pathways:
UniProt: Q9DB27
Entrez ID: 68995
|
Does Knockout of Elovl2 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Elovl2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Elovl2 (ELOVL fatty acid elongase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: alpha-linolenic acid metabolic process, fatty acid biosynthetic process, fatty acid derivative biosynthetic process, fatty acid elongation, monounsaturated fatty acid, fatty acid elongation, polyunsaturated fatty acid, fatty acid elongation, saturated fatty acid, fatty acid metabolic process, linoleic acid metabolic process, lipid biosynthetic process, lipid metabolic process, long-chain fatty acid biosynthetic process, sphingolipid biosynthetic process, unsaturated fatty acid biosynthetic process, very long-chain fatty acid biosynthetic process, very long-chain fatty acid metabolic process; MF: acyltransferase activity, transferring groups other than amino-acyl groups, fatty acid elongase activity, transferase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Biosynthesis of unsaturated fatty acids - Mus musculus (mouse), Fatty acid elongation - Mus musculus (mouse), Fatty acid metabolism, Fatty acyl-CoA biosynthesis, Linoleic acid (LA) metabolism, Metabolism, Metabolism of lipids, Synthesis of very long-chain fatty acyl-CoAs, alpha-linolenic (omega3) and linoleic (omega6) acid metabolism, alpha-linolenic acid (ALA) metabolism
UniProt: Q9JLJ4
Entrez ID: 54326
|
Does Knockout of Mrpl52 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,264
|
Knockout
|
Mrpl52
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Mrpl52 (mitochondrial ribosomal protein L52)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial translation, translation; MF: structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, nucleoplasm, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Translation
UniProt: Q9D0Y8
Entrez ID: 68836
|
Does Knockout of Ddost in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,265
|
Knockout
|
Ddost
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Ddost (dolichyl-di-phosphooligosaccharide-protein glycotransferase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell activation, protein N-linked glycosylation, protein N-linked glycosylation via asparagine, protein glycosylation, regulation of protein stability, response to cytokine; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, oligosaccharyltransferase complex, oligosaccharyltransferase complex A, oligosaccharyltransferase complex B
Pathways: Adaptive Immune System, Adherens junctions interactions, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Co-inhibition by PD-1, Immune System, Innate Immune System, N-Glycan biosynthesis - Mus musculus (mouse), Neutrophil degranulation, PD-L1(CD274) glycosylation and translocation to plasma membrane, Protein processing in endoplasmic reticulum - Mus musculus (mouse), Regulation of CDH1 Expression and Function, Regulation of CDH1 posttranslational processing and trafficking to plasma membrane, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of T cell activation by CD28 family, Various types of N-glycan biosynthesis - Mus musculus (mouse)
UniProt: O54734
Entrez ID: 13200
|
Does Knockout of Mypn in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 2,477
|
Knockout
|
Mypn
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Mypn (myopalladin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: axon guidance, dendrite self-avoidance, homophilic cell adhesion via plasma membrane adhesion molecules, sarcomere organization; MF: SH3 domain binding, actin binding, cell-cell adhesion mediator activity, cytoskeletal protein binding, muscle alpha-actinin binding; CC: I band, Z disc, axon, cytoplasm, cytosol, nucleoplasm, nucleus, plasma membrane, sarcomere
Pathways:
UniProt: Q5DTJ9
Entrez ID: 68802
|
Does Knockout of Naa38 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 579
|
Knockout
|
Naa38
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Naa38 (N(alpha)-acetyltransferase 38, NatC auxiliary subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of apoptotic process; MF: RNA binding, molecular_function; CC: NatC complex, cytoplasm, nucleoplasm, nucleus
Pathways:
UniProt: Q9D2U5
Entrez ID: 78304
|
Does Knockout of Psma5 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 2,176
|
Knockout
|
Psma5
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Psma5 (proteasome subunit alpha 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: proteasome-mediated ubiquitin-dependent protein catabolic process, proteolysis involved in protein catabolic process, ubiquitin-dependent protein catabolic process; CC: cytoplasm, cytosol, nucleoplasm, nucleus, proteasome complex, proteasome core complex, proteasome core complex, alpha-subunit complex
Pathways: ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, AUF1 (hnRNP D0) binds and destabilizes mRNA, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Activation of NF-kappaB in B cells, Adaptive Immune System, Adherens junctions interactions, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Antigen processing-Cross presentation, Antigen processing: Ub, ATP-independent proteasomal degradation, Antigen processing: Ubiquitination & Proteasome degradation, Assembly of the pre-replicative complex, Asymmetric localization of PCP proteins, Autodegradation of Cdh1 by Cdh1:APC/C, Autodegradation of the E3 ubiquitin ligase COP1, Beta-catenin independent WNT signaling, C-type lectin receptors (CLRs), CDK-mediated phosphorylation and removal of Cdc6, CLEC7A (Dectin-1) signaling, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cellular response to chemical stress, Cellular response to hypoxia, Cellular responses to stimuli, Cellular responses to stress, Circadian clock, Class I MHC mediated antigen processing & presentation, Co-inhibition by PD-1, Cross-presentation of soluble exogenous antigens (endosomes), Cyclin A:Cdk2-associated events at S phase entry, Cyclin E associated events during G1/S transition , Cytokine Signaling in Immune system, DNA Replication, DNA Replication Pre-Initiation, Dectin-1 mediated noncanonical NF-kB signaling, Degradation of AXIN, Degradation of CDH1, Degradation of CRY and PER proteins, Degradation of DVL, Degradation of GLI1 by the proteasome, Degradation of beta-catenin by the destruction complex, Deubiquitination, Downstream TCR signaling, Downstream signaling events of B Cell Receptor (BCR), ER-Phagosome pathway, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, FCERI mediated NF-kB activation, Fc epsilon receptor (FCERI) signaling, G1/S DNA Damage Checkpoints, G1/S Transition, G2/M Checkpoints, G2/M Transition, GLI3 is processed to GLI3R by the proteasome, GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2, GSK3B-mediated proteasomal degradation of PD-L1(CD274), Gene expression (Transcription), Generic Transcription Pathway, Hedgehog 'off' state, Hedgehog 'on' state, Hedgehog ligand biogenesis, Huntington disease - Mus musculus (mouse), Immune System, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, Intracellular signaling by second messengers, KEAP1-NFE2L2 pathway, M Phase, MAPK family signaling cascades, MAPK1/MAPK3 signaling, MAPK6/MAPK4 signaling, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of polyamines, Metabolism of proteins, Mitotic Anaphase, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, NIK-->noncanonical NF-kB signaling, Neddylation, Neutrophil degranulation, Nuclear events mediated by NFE2L2, Orc1 removal from chromatin, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, PCP/CE pathway, PIP3 activates AKT signaling, PTEN Regulation, Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Post-translational protein modification, Prion disease - Mus musculus (mouse), Proteasome - Mus musculus (mouse), Proteasome assembly, RAF/MAP kinase cascade, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of PTEN stability and activity, Regulation of RAS by GAPs, Regulation of RUNX2 expression and activity, Regulation of RUNX3 expression and activity, Regulation of T cell activation by CD28 family, Regulation of mRNA stability by proteins that bind AU-rich elements, Regulation of mitotic cell cycle, Regulation of ornithine decarboxylase (ODC), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, S Phase, SCF(Skp2)-mediated degradation of p27/p21, SPOP-mediated proteasomal degradation of PD-L1(CD274), Separation of Sister Chromatids, Signal Transduction, Signaling by Hedgehog, Signaling by Interleukins, Signaling by WNT, Signaling by the B Cell Receptor (BCR), Spinocerebellar ataxia - Mus musculus (mouse), Stabilization of p53, Switching of origins to a post-replicative state, Synthesis of DNA, TCF dependent signaling in response to WNT, TCR signaling, TNFR2 non-canonical NF-kB pathway, Targeted protein degradation, The role of GTSE1 in G2/M progression after G2 checkpoint, Transcriptional regulation by RUNX1, Transcriptional regulation by RUNX2, Transcriptional regulation by RUNX3, Translation, Transport of small molecules, UCH proteinases, Ub-specific processing proteases, Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, Ubiquitin-dependent degradation of Cyclin D, p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint, p53-Independent G1/S DNA Damage Checkpoint
UniProt: Q9Z2U1
Entrez ID: 26442
|
Does Knockout of P3h1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
P3h1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: P3h1 (prolyl 3-hydroxylase 1)
Type: protein-coding
Summary: Predicted to enable procollagen-proline 3-dioxygenase activity. Acts upstream of or within collagen fibril organization; negative regulation of cell growth; and regulation of ossification. Predicted to be located in basement membrane; cytoplasm; and nucleus. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including alimentary system; genitourinary system; limb mesenchyme; sensory organ; and skeleton. Used to study osteogenesis imperfecta type 8. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 8. Orthologous to human P3H1 (prolyl 3-hydroxylase 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: bone development, collagen fibril organization, collagen metabolic process, negative regulation of cell growth, negative regulation of post-translational protein modification, positive regulation of neuron projection development, protein folding, protein stabilization, regulation of ossification, regulation of protein secretion; MF: L-ascorbic acid binding, dioxygenase activity, iron ion binding, metal ion binding, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, procollagen-proline 3-dioxygenase activity; CC: basement membrane, cytoplasm, endoplasmic reticulum, extracellular region, nucleus, plasma membrane
Pathways:
UniProt: Q3V1T4
Entrez ID: 56401
|
Does Knockout of Enpp3 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Enpp3
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Enpp3 (ectonucleotide pyrophosphatase/phosphodiesterase 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ATP metabolic process, basophil activation involved in immune response, negative regulation of cGAS/STING signaling pathway, negative regulation of inflammatory response, negative regulation of mast cell activation involved in immune response, negative regulation of mast cell proliferation, nucleoside triphosphate catabolic process, phosphate ion homeostasis, phosphate-containing compound metabolic process, pyrimidine nucleotide metabolic process; MF: ATP binding, ATP diphosphatase activity, GTP diphosphatase activity, UTP diphosphatase activity, bis(5'-adenosyl)-pentaphosphatase activity, bis(5'-adenosyl)-triphosphatase activity, bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity, calcium ion binding, catalytic activity, cyclic-GMP-AMP hydrolase activity, hydrolase activity, metal ion binding, nucleic acid binding, nucleoside triphosphate diphosphatase activity, nucleotide binding, phosphodiesterase I activity, zinc ion binding; CC: apical plasma membrane, cell surface, external side of plasma membrane, extracellular region, membrane, perinuclear region of cytoplasm, plasma membrane
Pathways: Nicotinate and nicotinamide metabolism - Mus musculus (mouse), Pantothenate and CoA biosynthesis - Mus musculus (mouse), Purine metabolism - Mus musculus (mouse), Pyrimidine metabolism - Mus musculus (mouse), Riboflavin metabolism - Mus musculus (mouse), Starch and sucrose metabolism - Mus musculus (mouse)
UniProt: Q6DYE8
Entrez ID: 209558
|
Does Knockout of Nrip2 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Nrip2
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Nrip2 (nuclear receptor interacting protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Notch signaling pathway, negative regulation of transcription by RNA polymerase II; CC: cytoplasm, nucleus
Pathways:
UniProt: Q9JHR9
Entrez ID: 60345
|
Does Knockout of Fam98b in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,289
|
Knockout
|
Fam98b
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Fam98b (family with sequence similarity 98, member B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of cell population proliferation, positive regulation of gene expression, protein methylation; MF: identical protein binding, protein methyltransferase activity; CC: cytoplasm, nucleoplasm, nucleus, tRNA-splicing ligase complex
Pathways:
UniProt: Q80VD1
Entrez ID: 68215
|
Does Knockout of Gas6 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Gas6
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Gas6 (growth arrest specific 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell chemotaxis, activation of protein kinase B activity, animal organ regeneration, apoptotic cell clearance, blood coagulation, calcium ion transmembrane transport, cell differentiation, cell migration, cell surface receptor signaling pathway, cell-substrate adhesion, cellular response to glucose stimulus, cellular response to growth factor stimulus, cellular response to interferon-alpha, cellular response to nutrient levels, cellular response to starvation, cellular response to vitamin K, cellular response to xenobiotic stimulus, dendritic cell differentiation, enzyme-linked receptor protein signaling pathway, extracellular matrix assembly, fusion of virus membrane with host plasma membrane, hematopoietic stem cell migration to bone marrow, negative regulation of DNA-templated transcription, negative regulation of apoptotic process, negative regulation of biomineral tissue development, negative regulation of dendritic cell apoptotic process, negative regulation of endothelial cell apoptotic process, negative regulation of fibroblast apoptotic process, negative regulation of interleukin-1 production, negative regulation of interleukin-6 production, negative regulation of myeloid cell apoptotic process, negative regulation of oligodendrocyte apoptotic process, negative regulation of renal albumin absorption, negative regulation of tumor necrosis factor production, negative regulation of tumor necrosis factor-mediated signaling pathway, negative regulation of type II interferon production, neuron migration, phagocytosis, positive regulation of ERK1 and ERK2 cascade, positive regulation of TOR signaling, positive regulation of cytokine-mediated signaling pathway, positive regulation of dendritic cell chemotaxis, positive regulation of fibroblast proliferation, positive regulation of gene expression, positive regulation of glomerular filtration, positive regulation of natural killer cell differentiation, positive regulation of phagocytosis, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of protein export from nucleus, positive regulation of protein kinase activity, positive regulation of protein phosphorylation, protein localization to plasma membrane, protein phosphorylation, receptor-mediated virion attachment to host cell, regulation of body fluid levels, signal transduction, symbiont entry into host cell, viral genome replication; MF: calcium ion binding, cysteine-type endopeptidase inhibitor activity involved in apoptotic process, metal ion binding, phosphatidylserine binding, protein-macromolecule adaptor activity, receptor ligand activity, receptor tyrosine kinase binding, signaling receptor binding; CC: cytoplasm, extracellular region, extracellular space
Pathways: Cell surface interactions at the vascular wall, Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation, Gamma-carboxylation, transport, and amino-terminal cleavage of proteins, Hemostasis, Metabolism of proteins, Platelet activation, signaling and aggregation, Platelet degranulation , Post-translational protein modification, Post-translational protein phosphorylation, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Removal of aminoterminal propeptides from gamma-carboxylated proteins, Response to elevated platelet cytosolic Ca2+, Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
UniProt: Q61592
Entrez ID: 14456
|
Does Knockout of Gpn2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Gpn2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Gpn2 (GPN-loop GTPase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: GTP binding, GTPase activity, hydrolase activity, nucleotide binding
Pathways:
UniProt: Q8VEJ1
Entrez ID: 100210
|
Does Knockout of Cxcl10 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,171
|
Knockout
|
Cxcl10
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Cxcl10 (C-X-C motif chemokine ligand 10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, T cell chemotaxis, adenylate cyclase-activating G protein-coupled receptor signaling pathway, antimicrobial humoral immune response mediated by antimicrobial peptide, antiviral innate immune response, cellular response to interleukin-17, cellular response to lipopolysaccharide, cellular response to virus, chemokine-mediated signaling pathway, chemotaxis, defense response, defense response to virus, endothelial cell activation, immune response, inflammatory response, killing of cells of another organism, negative regulation of angiogenesis, negative regulation of myoblast differentiation, negative regulation of myoblast fusion, neutrophil chemotaxis, positive chemotaxis, positive regulation of T cell migration, positive regulation of cell migration, positive regulation of cell population proliferation, positive regulation of leukocyte chemotaxis, positive regulation of monocyte chemotaxis, positive regulation of release of sequestered calcium ion into cytosol, regulation of T cell chemotaxis, regulation of apoptotic process, regulation of cell population proliferation, regulation of endothelial tube morphogenesis, response to bacterium; MF: CXCR chemokine receptor binding, CXCR3 chemokine receptor binding, chemoattractant activity, chemokine activity, cytokine activity, heparin binding; CC: external side of plasma membrane, extracellular region, extracellular space
Pathways: Chemokine receptors bind chemokines, Chemokine signaling pathway - Mus musculus (mouse), Class A/1 (Rhodopsin-like receptors), Coronavirus disease - COVID-19 - Mus musculus (mouse), Cytokine-cytokine receptor interaction - Mus musculus (mouse), Cytosolic DNA-sensing pathway - Mus musculus (mouse), Epstein-Barr virus infection - Mus musculus (mouse), G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, Hepatitis C - Mus musculus (mouse), IL-17 signaling pathway - Mus musculus (mouse), Influenza A - Mus musculus (mouse), Peptide ligand-binding receptors, RIG-I-like receptor signaling pathway - Mus musculus (mouse), Signal Transduction, Signaling by GPCR, TNF signaling pathway - Mus musculus (mouse), Toll-like receptor signaling pathway - Mus musculus (mouse), Viral protein interaction with cytokine and cytokine receptor - Mus musculus (mouse)
UniProt: P17515
Entrez ID: 15945
|
Does Knockout of Trpc6 in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Trpc6
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Trpc6 (transient receptor potential cation channel, subfamily C, member 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: calcium ion transmembrane transport, calcium ion transport, cellular response to hydrogen peroxide, cellular response to hypoxia, monoatomic ion transmembrane transport, monoatomic ion transport, negative regulation of dendrite morphogenesis, neuron differentiation, positive regulation of calcium ion transport, positive regulation of cytosolic calcium ion concentration, positive regulation of neuron differentiation, regulation of cytosolic calcium ion concentration, single fertilization, transmembrane transport; MF: ATPase binding, actin binding, actinin binding, calcium channel activity, clathrin binding, inositol 1,4,5 trisphosphate binding, monoatomic cation channel activity, monoatomic ion channel activity, protein binding, protein homodimerization activity, store-operated calcium channel activity; CC: cation channel complex, cytoplasm, membrane, plasma membrane, slit diaphragm
Pathways: Axon guidance - Mus musculus (mouse), Effects of PIP2 hydrolysis, Elevation of cytosolic Ca2+ levels, G alpha (q) signalling events, GPCR downstream signalling, Hemostasis, Ion channel transport, Platelet activation, signaling and aggregation, Platelet calcium homeostasis, Platelet homeostasis, Signal Transduction, Signaling by GPCR, Stimuli-sensing channels, TRP channels, Transport of small molecules, cGMP-PKG signaling pathway - Mus musculus (mouse)
UniProt: Q61143
Entrez ID: 22068
|
Does Knockout of Scn2b in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Scn2b
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Scn2b (sodium channel, voltage-gated, type II, beta)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cardiac conduction, cardiac muscle cell action potential involved in contraction, cardiac muscle contraction, gene expression, membrane depolarization during action potential, membrane depolarization during cardiac muscle cell action potential, membrane repolarization during ventricular cardiac muscle cell action potential, monoatomic ion transport, nervous system development, positive regulation of sodium ion transport, regulation of atrial cardiac muscle cell membrane depolarization, regulation of heart rate by cardiac conduction, response to heat, response to pyrethroid, sodium ion transmembrane transport, sodium ion transport; MF: sodium channel regulator activity, voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization, voltage-gated sodium channel activity, voltage-gated sodium channel activity involved in cardiac muscle cell action potential; CC: T-tubule, axon, axon initial segment, cell projection, membrane, node of Ranvier, plasma membrane, voltage-gated sodium channel complex
Pathways:
UniProt: Q56A07
Entrez ID: 72821
|
Does Knockout of Zfp61 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Zfp61
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Zfp61 (zinc finger protein 61)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: DNA binding, metal ion binding, zinc ion binding
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Mus musculus (mouse), RNA Polymerase II Transcription
UniProt: D3Z6B8, Q923D1
Entrez ID: 22719
|
Does Knockout of Gxylt1 in Embryonic Fibroblast Cell Line causally result in autophagy?
| 1
| 1,044
|
Knockout
|
Gxylt1
|
autophagy
|
Embryonic Fibroblast Cell Line
|
Gene: Gxylt1 (glucoside xylosyltransferase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein O-linked glycosylation via N-acetyl-galactosamine, protein O-linked glycosylation via glucose; MF: UDP-D-xylose:beta-D-glucoside alpha-1,3-D-xylosyltransferase activity, UDP-xylosyltransferase activity, glycosyltransferase activity, transferase activity; CC: cellular_component, membrane
Pathways: Other types of O-glycan biosynthesis - Mus musculus (mouse)
UniProt: Q3UHH8
Entrez ID: 223827
|
Does Knockout of Qrich1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,289
|
Knockout
|
Qrich1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Qrich1 (glutamine-rich 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: PERK-mediated unfolded protein response, endoplasmic reticulum unfolded protein response, integrated stress response signaling, intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress, kidney development, positive regulation of DNA-templated transcription, positive regulation of apoptotic process, response to endoplasmic reticulum stress, response to unfolded protein; MF: DNA binding; CC: cytoplasm, membrane, nucleus, plasma membrane
Pathways:
UniProt: Q3UA37
Entrez ID: 69232
|
Does Knockout of Catsperd in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Catsperd
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Catsperd (cation channel sperm associated auxiliary subunit delta)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, flagellated sperm motility, sperm capacitation, spermatogenesis; CC: CatSper complex, cell projection, cilium, membrane, motile cilium, plasma membrane, sperm principal piece
Pathways: Fertilization, Reproduction, Sperm Motility And Taxes
UniProt: E9Q9F6
Entrez ID: 106757
|
Does Knockout of N4bp1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
N4bp1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: N4bp1 (NEDD4 binding protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to UV, immune system process, innate immune response, negative regulation of cytokine production, negative regulation of proteasomal ubiquitin-dependent protein catabolic process, negative regulation of protein ubiquitination, negative regulation of viral genome replication, regulation of innate immune response; MF: RNA binding, RNA nuclease activity, hydrolase activity, mRNA binding, nuclease activity, protein binding, ubiquitin binding; CC: PML body, cytoplasm, cytosol, nucleolus, nucleus
Pathways: Cytokine Signaling in Immune system, Immune System, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, MyD88 cascade initiated on plasma membrane, MyD88 dependent cascade initiated on endosome, MyD88-independent TLR4 cascade , MyD88:MAL(TIRAP) cascade initiated on plasma membrane, Regulation of NF-kappa B signaling, Signaling by Interleukins, TAK1-dependent IKK and NF-kappa-B activation , TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, TRIF (TICAM1)-mediated TLR4 signaling , Toll Like Receptor 10 (TLR10) Cascade, Toll Like Receptor 2 (TLR2) Cascade, Toll Like Receptor 3 (TLR3) Cascade, Toll Like Receptor 4 (TLR4) Cascade, Toll Like Receptor 5 (TLR5) Cascade, Toll Like Receptor 7/8 (TLR7/8) Cascade, Toll Like Receptor 9 (TLR9) Cascade, Toll Like Receptor TLR1:TLR2 Cascade, Toll Like Receptor TLR6:TLR2 Cascade, Toll-like Receptor Cascades
UniProt: Q6A037
Entrez ID: 80750
|
Does Knockout of Psmb7 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Psmb7
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Psmb7 (proteasome (prosome, macropain) subunit, beta type 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: proteasome-mediated ubiquitin-dependent protein catabolic process, proteolysis, proteolysis involved in protein catabolic process; MF: endopeptidase activity, hydrolase activity, peptidase activity, threonine-type endopeptidase activity; CC: cilium, cytoplasm, cytosol, nuclear body, nucleoplasm, nucleus, proteasome complex, proteasome core complex, proteasome core complex, beta-subunit complex
Pathways: ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, AUF1 (hnRNP D0) binds and destabilizes mRNA, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Activation of NF-kappaB in B cells, Adaptive Immune System, Adherens junctions interactions, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Antigen processing-Cross presentation, Antigen processing: Ub, ATP-independent proteasomal degradation, Antigen processing: Ubiquitination & Proteasome degradation, Assembly of the pre-replicative complex, Asymmetric localization of PCP proteins, Autodegradation of Cdh1 by Cdh1:APC/C, Autodegradation of the E3 ubiquitin ligase COP1, Beta-catenin independent WNT signaling, C-type lectin receptors (CLRs), CDK-mediated phosphorylation and removal of Cdc6, CLEC7A (Dectin-1) signaling, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cellular response to chemical stress, Cellular response to hypoxia, Cellular responses to stimuli, Cellular responses to stress, Circadian clock, Class I MHC mediated antigen processing & presentation, Co-inhibition by PD-1, Cross-presentation of soluble exogenous antigens (endosomes), Cyclin A:Cdk2-associated events at S phase entry, Cyclin E associated events during G1/S transition , Cytokine Signaling in Immune system, DNA Replication, DNA Replication Pre-Initiation, Dectin-1 mediated noncanonical NF-kB signaling, Degradation of AXIN, Degradation of CDH1, Degradation of CRY and PER proteins, Degradation of DVL, Degradation of GLI1 by the proteasome, Degradation of beta-catenin by the destruction complex, Deubiquitination, Downstream TCR signaling, Downstream signaling events of B Cell Receptor (BCR), ER-Phagosome pathway, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, FCERI mediated NF-kB activation, Fc epsilon receptor (FCERI) signaling, G1/S DNA Damage Checkpoints, G1/S Transition, G2/M Checkpoints, G2/M Transition, GLI3 is processed to GLI3R by the proteasome, GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2, GSK3B-mediated proteasomal degradation of PD-L1(CD274), Gene expression (Transcription), Generic Transcription Pathway, Hedgehog 'off' state, Hedgehog 'on' state, Hedgehog ligand biogenesis, Huntington disease - Mus musculus (mouse), Immune System, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, Intracellular signaling by second messengers, KEAP1-NFE2L2 pathway, M Phase, MAPK family signaling cascades, MAPK1/MAPK3 signaling, MAPK6/MAPK4 signaling, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of polyamines, Metabolism of proteins, Mitotic Anaphase, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, NIK-->noncanonical NF-kB signaling, Neddylation, Neutrophil degranulation, Nuclear events mediated by NFE2L2, Orc1 removal from chromatin, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, PCP/CE pathway, PIP3 activates AKT signaling, PTEN Regulation, Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Post-translational protein modification, Prion disease - Mus musculus (mouse), Proteasome - Mus musculus (mouse), Proteasome assembly, RAF/MAP kinase cascade, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of PTEN stability and activity, Regulation of RAS by GAPs, Regulation of RUNX2 expression and activity, Regulation of RUNX3 expression and activity, Regulation of T cell activation by CD28 family, Regulation of mRNA stability by proteins that bind AU-rich elements, Regulation of mitotic cell cycle, Regulation of ornithine decarboxylase (ODC), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, S Phase, SCF(Skp2)-mediated degradation of p27/p21, SPOP-mediated proteasomal degradation of PD-L1(CD274), Separation of Sister Chromatids, Signal Transduction, Signaling by Hedgehog, Signaling by Interleukins, Signaling by WNT, Signaling by the B Cell Receptor (BCR), Spinocerebellar ataxia - Mus musculus (mouse), Stabilization of p53, Switching of origins to a post-replicative state, Synthesis of DNA, TCF dependent signaling in response to WNT, TCR signaling, TNFR2 non-canonical NF-kB pathway, Targeted protein degradation, The role of GTSE1 in G2/M progression after G2 checkpoint, Transcriptional regulation by RUNX1, Transcriptional regulation by RUNX2, Transcriptional regulation by RUNX3, Translation, Transport of small molecules, UCH proteinases, Ub-specific processing proteases, Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, Ubiquitin-dependent degradation of Cyclin D, p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint, p53-Independent G1/S DNA Damage Checkpoint
UniProt: P70195
Entrez ID: 19177
|
Does Knockout of Uba2 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Uba2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Uba2 (ubiquitin-like modifier activating enzyme 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of protein sumoylation, protein sumoylation; MF: ATP binding, SUMO activating enzyme activity, SUMO binding, magnesium ion binding, metal ion binding, nucleotide binding, protein binding, protein heterodimerization activity, small protein activating enzyme binding, transferase activity, ubiquitin-like modifier activating enzyme activity, ubiquitin-like protein conjugating enzyme binding; CC: SUMO activating enzyme complex, cytoplasm, nucleolus, nucleoplasm, nucleus
Pathways: Metabolism of proteins, Post-translational protein modification, Processing and activation of SUMO, SUMO is conjugated to E1 (UBA2:SAE1), SUMO is transferred from E1 to E2 (UBE2I, UBC9), SUMOylation, Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: Q9Z1F9
Entrez ID: 50995
|
Does Knockout of Polr2l in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 579
|
Knockout
|
Polr2l
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Polr2l (polymerase (RNA) II (DNA directed) polypeptide L)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA-templated transcription, tRNA transcription by RNA polymerase III, transcription by RNA polymerase I, transcription by RNA polymerase II; MF: DNA binding, DNA-directed RNA polymerase activity, metal ion binding, zinc ion binding; CC: DNA-directed RNA polymerase complex, RNA polymerase I complex, RNA polymerase II, core complex, RNA polymerase III complex, nucleolus, nucleoplasm, nucleus
Pathways: B-WICH complex positively regulates rRNA expression, Cytosolic DNA-sensing pathway - Mus musculus (mouse), DNA Repair, Dual incision in TC-NER, ESR-mediated signaling, Epigenetic regulation of gene expression, Estrogen-dependent gene expression, FGFR2 alternative splicing, Formation of RNA Pol II elongation complex , Formation of TC-NER Pre-Incision Complex, Formation of the Early Elongation Complex, Gap-filling DNA repair synthesis and ligation in TC-NER, Gene expression (Transcription), Generic Transcription Pathway, Huntington disease - Mus musculus (mouse), Metabolism of RNA, Nucleotide Excision Repair, Positive epigenetic regulation of rRNA expression, Processing of Capped Intron-Containing Pre-mRNA, RNA Pol II CTD phosphorylation and interaction with CE, RNA Polymerase I Promoter Clearance, RNA Polymerase I Promoter Escape, RNA Polymerase I Transcription, RNA Polymerase I Transcription Initiation, RNA Polymerase I Transcription Termination, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Promoter Escape, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, RNA Polymerase II Transcription Initiation, RNA Polymerase II Transcription Initiation And Promoter Clearance, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, RNA Polymerase III Transcription, RNA Polymerase III Transcription Initiation, RNA Polymerase III Transcription Initiation From Type 1 Promoter, RNA Polymerase III Transcription Initiation From Type 2 Promoter, RNA Polymerase III Transcription Initiation From Type 3 Promoter, RNA polymerase - Mus musculus (mouse), RNA polymerase II transcribes snRNA genes, Signal Transduction, Signaling by FGFR, Signaling by FGFR2, Signaling by Nuclear Receptors, Signaling by Receptor Tyrosine Kinases, TP53 Regulates Transcription of DNA Repair Genes, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Transcriptional Regulation by TP53, mRNA Capping, mRNA Splicing, mRNA Splicing - Major Pathway, mRNA Splicing - Minor Pathway
UniProt: P62876
Entrez ID: 66491
|
Does Knockout of Nip7 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Nip7
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Nip7 (NIP7, nucleolar pre-rRNA processing protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ribosomal large subunit biogenesis, ribosome assembly, ribosome biogenesis; CC: cytoplasm, cytosol, nucleolus, nucleoplasm, nucleus, preribosome, large subunit precursor
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9CXK8
Entrez ID: 66164
|
Does Knockout of Vmn1r46 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Vmn1r46
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Vmn1r46 (vomeronasal 1 receptor 46)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled receptor activity, pheromone binding, pheromone receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: Q9EQ45
Entrez ID: 113856
|
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