prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of D830030K20Rik in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
D830030K20Rik
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: D830030K20Rik (RIKEN cDNA D830030K20 gene)
Type: protein-coding
Summary: RIKEN cDNA D830030K20 gene
Gene Ontology:
Pathways:
UniProt: E9PYQ5, Q8BGG1
Entrez ID: 320333
|
Does Knockout of Herpud1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Herpud1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Herpud1 (homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ERAD pathway, endoplasmic reticulum calcium ion homeostasis, endoplasmic reticulum unfolded protein response, intracellular calcium ion homeostasis, negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway, negative regulation of intrinsic apoptotic signaling pathway, positive regulation of ERAD pathway, positive regulation of ubiquitin-dependent protein catabolic process, protein targeting to ER, regulation of ERAD pathway, regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway, regulation of protein ubiquitination, response to endoplasmic reticulum stress, response to unfolded protein, retrograde protein transport, ER to cytosol, ubiquitin-dependent protein catabolic process; MF: protein binding, transmembrane transporter binding, ubiquitin-like ligase-substrate adaptor activity; CC: Hrd1p ubiquitin ligase complex, Lewy body core, endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum quality control compartment, membrane
Pathways: Protein processing in endoplasmic reticulum - Mus musculus (mouse)
UniProt: Q9JJK5
Entrez ID: 64209
|
Does Knockout of Qpct in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Qpct
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Qpct (glutaminyl-peptide cyclotransferase (glutaminyl cyclase))
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: acyltransferase activity, glutaminyl-peptide cyclotransferase activity, metal ion binding, transferase activity, zinc ion binding
Pathways: Immune System, Innate Immune System, Neutrophil degranulation
UniProt: Q9CYK2
Entrez ID: 70536
|
Does Knockout of Lhfpl1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Lhfpl1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Lhfpl1 (lipoma HMGIC fusion partner-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: membrane
Pathways:
UniProt: Q80SV1
Entrez ID: 237091
|
Does Knockout of Ubn2 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Ubn2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Ubn2 (ubinuclein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: nucleoplasm, nucleus
Pathways:
UniProt: Q80WC1
Entrez ID: 320538
|
Does Knockout of Ice1 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Ice1
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Ice1 (interactor of little elongation complex ELL subunit 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of intracellular protein transport, positive regulation of protein-containing complex assembly, positive regulation of transcription by RNA polymerase III, snRNA transcription by RNA polymerase II, snRNA transcription by RNA polymerase III; MF: protein-macromolecule adaptor activity; CC: Cajal body, euchromatin, histone locus body, nuclear body, nucleoplasm, nucleus, transcription elongation factor complex
Pathways: Gene expression (Transcription), RNA Polymerase II Transcription, RNA polymerase II transcribes snRNA genes
UniProt: E9Q286
Entrez ID: 218333
|
Does Knockout of Rbp2 in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
Rbp2
|
cell cycle progression
|
breast epithelium
|
Gene: Rbp2 (retinol binding protein 2, cellular)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: fatty acid transport, retinoid metabolic process, triglyceride biosynthetic process; MF: binding, enzyme-substrate adaptor activity, fatty acid binding, lipid binding, molecular carrier activity, retinal binding, retinoid binding, retinol binding, transmembrane transporter binding; CC: cytoplasm, cytosol, nucleus, synaptic ribbon
Pathways: Metabolism, Metabolism of fat-soluble vitamins, Metabolism of vitamins and cofactors, Retinoid metabolism and transport, Sensory Perception, Visual phototransduction, Vitamin digestion and absorption - Mus musculus (mouse)
UniProt: Q08652
Entrez ID: 19660
|
Does Knockout of Tuba1a in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Tuba1a
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Tuba1a (tubulin, alpha 1A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adult behavior, adult locomotory behavior, cellular response to calcium ion, centrosome cycle, cerebellar cortex morphogenesis, cerebral cortex development, dentate gyrus development, flagellated sperm motility, forebrain morphogenesis, gene expression, glial cell differentiation, hippocampus development, homeostasis of number of cells within a tissue, intracellular protein transport, locomotory behavior, locomotory exploration behavior, memory, microtubule cytoskeleton organization, microtubule polymerization, microtubule-based process, mitotic cell cycle, motor behavior, neurogenesis, neuron apoptotic process, neuron differentiation, neuron migration, neuron projection arborization, organelle transport along microtubule, pyramidal neuron differentiation, regulation of synapse organization, response to L-glutamate, response to mechanical stimulus, response to tumor necrosis factor, smoothened signaling pathway, startle response, synapse organization, visual learning; MF: GTP binding, hydrolase activity, identical protein binding, metal ion binding, nucleotide binding, protein binding, protein domain specific binding, protein heterodimerization activity, protein-containing complex binding, structural constituent of cytoskeleton; CC: axonemal microtubule, cell projection, cilium, condensed chromosome, cytoplasm, cytoplasmic microtubule, cytoplasmic ribonucleoprotein granule, cytoskeleton, cytosol, membrane raft, microtubule, microtubule cytoskeleton, motile cilium, myelin sheath, neuromuscular junction, plasma membrane, recycling endosome, sperm flagellum, synapse
Pathways: AURKA Activation by TPX2, Adaptive Immune System, Aggrephagy, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Anchoring of the basal body to the plasma membrane, Antiviral mechanism by IFN-stimulated genes, Apoptosis - Mus musculus (mouse), Asparagine N-linked glycosylation, Autophagy, Axon guidance, COPI-dependent Golgi-to-ER retrograde traffic, COPI-independent Golgi-to-ER retrograde traffic, COPI-mediated anterograde transport, Carboxyterminal post-translational modifications of tubulin, Cargo trafficking to the periciliary membrane, Cell Cycle, Cell Cycle, Mitotic, Cellular responses to stimuli, Cellular responses to stress, Centrosome maturation, Cilium Assembly, Cytokine Signaling in Immune system, Developmental Biology, EML4 and NUDC in mitotic spindle formation, ER to Golgi Anterograde Transport, Factors involved in megakaryocyte development and platelet production, G2/M Transition, Gap junction - Mus musculus (mouse), Gap junction assembly, Gap junction trafficking, Gap junction trafficking and regulation, Golgi-to-ER retrograde transport, HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand, Hedgehog 'off' state, Hemostasis, Huntington disease - Mus musculus (mouse), Immune System, Interferon Signaling, Intra-Golgi and retrograde Golgi-to-ER traffic, Intraflagellar transport, Kinesins, L1CAM interactions, Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, MHC class II antigen presentation, Macroautophagy, Membrane Trafficking, Metabolism of proteins, Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane, Mitotic Anaphase, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Nervous system development, Nuclear Envelope (NE) Reassembly, Organelle biogenesis and maintenance, PKR-mediated signaling, Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Phagosome - Mus musculus (mouse), Post-translational protein modification, Prion disease - Mus musculus (mouse), RHO GTPase Effectors, RHO GTPases Activate Formins, RHO GTPases activate IQGAPs, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Recycling pathway of L1, Regulation of PLK1 Activity at G2/M Transition, Resolution of Sister Chromatid Cohesion, Salmonella infection - Mus musculus (mouse), Sealing of the nuclear envelope (NE) by ESCRT-III, Selective autophagy, Separation of Sister Chromatids, Signal Transduction, Signaling by Hedgehog, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, The role of GTSE1 in G2/M progression after G2 checkpoint, Tight junction - Mus musculus (mouse), Transport of connexons to the plasma membrane, Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: P68369
Entrez ID: 22142
|
Does Knockout of Tspan13 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Tspan13
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Tspan13 (tetraspanin 13)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: calcium channel regulator activity, protein binding; CC: membrane, plasma membrane
Pathways:
UniProt: Q9D8C2
Entrez ID: 66109
|
Does Knockout of Taf1c in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Taf1c
|
phagocytosis
|
macrophage
|
Gene: Taf1c (TATA-box binding protein associated factor, RNA polymerase I, C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA polymerase I preinitiation complex assembly, transcription by RNA polymerase I; MF: DNA binding, RNA polymerase I core promoter sequence-specific DNA binding, RNA polymerase I general transcription initiation factor activity, protein binding; CC: RNA polymerase I transcription regulator complex, RNA polymerase transcription factor SL1 complex, fibrillar center, nucleolus, nucleoplasm, nucleus
Pathways: B-WICH complex positively regulates rRNA expression, Epigenetic regulation of gene expression, Gene expression (Transcription), Positive epigenetic regulation of rRNA expression, RNA Polymerase I Promoter Clearance, RNA Polymerase I Promoter Escape, RNA Polymerase I Transcription, RNA Polymerase I Transcription Initiation, RNA Polymerase I Transcription Termination
UniProt: Q6PDZ2
Entrez ID: 21341
|
Does Knockout of Cachd1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 82
|
Knockout
|
Cachd1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Cachd1 (cache domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: calcium ion transmembrane transport, calcium ion transport, monoatomic ion transport; CC: membrane, voltage-gated calcium channel complex
Pathways:
UniProt: Q6PDJ1
Entrez ID: 320508
|
Does Knockout of Cd1d2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Cd1d2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Cd1d2 (CD1d2 antigen)
Type: protein-coding
Summary: This gene encodes a MHC class I-like molecule involved in the presentation of lipid antigens to T cells, and is involved in the activation of Natural Killer T (NKT) cells. The gene is highly similar to the CD1d1 antigen gene, which is located adjacent to this gene in a tail-to-tail fashion. This gene contains a frameshift and does not produce a functional product in the C57BL/6 strain. Alternatively splice transcript variants encoding different isoforms have been found in non-C57BL/6 strains. [provided by RefSeq, Jan 2014].
Gene Ontology: BP: antigen processing and presentation, endogenous lipid antigen via MHC class Ib, antigen processing and presentation, exogenous lipid antigen via MHC class Ib, immune response, immune system process, innate immune response, positive regulation of NK T cell activation, positive regulation of T cell mediated cytotoxicity, positive regulation of T cell proliferation, positive regulation of interleukin-2 production, positive regulation of interleukin-4 production; MF: cell adhesion molecule binding, endogenous lipid antigen binding, exogenous lipid antigen binding, lipid antigen binding, lipopeptide binding; CC: cell surface, cytoplasm, endoplasmic reticulum, endosome, endosome membrane, external side of plasma membrane, extracellular space, lysosomal membrane, lysosome, membrane, plasma membrane
Pathways: Amoebiasis - Mus musculus (mouse), Hematopoietic cell lineage - Mus musculus (mouse), Tight junction - Mus musculus (mouse)
UniProt: P11610
Entrez ID: 12480
|
Does Knockout of Ppp2r3a in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,181
|
Knockout
|
Ppp2r3a
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Ppp2r3a (protein phosphatase 2, regulatory subunit B'', alpha)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: eye photoreceptor cell differentiation, negative regulation of canonical Wnt signaling pathway, positive regulation of canonical Wnt signaling pathway, positive regulation of protein catabolic process, regulation of canonical Wnt signaling pathway, regulation of cell migration involved in somitogenic axis elongation, somatic muscle development, somitogenesis; MF: calcium ion binding, metal ion binding, protein phosphatase regulator activity, protein-macromolecule adaptor activity; CC: protein phosphatase type 2A complex
Pathways: AMPK signaling pathway - Mus musculus (mouse), Adrenergic signaling in cardiomyocytes - Mus musculus (mouse), Dopaminergic synapse - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), Sphingolipid signaling pathway - Mus musculus (mouse), mRNA surveillance pathway - Mus musculus (mouse)
UniProt: Q3V1Y6, B2RXC8, G3X9E8, Q8BXX8
Entrez ID: 235542
|
Does Knockout of Upf1 in Acute Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 684
|
Knockout
|
Upf1
|
cell proliferation
|
Acute Myeloid Leukemia Cell Line
|
Gene: Upf1 (UPF1 RNA helicase and ATPase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 3'-UTR-mediated mRNA destabilization, DNA repair, DNA replication, cell cycle phase transition, cellular response to interleukin-1, cellular response to lipopolysaccharide, histone mRNA catabolic process, nuclear-transcribed mRNA catabolic process, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, positive regulation of mRNA catabolic process, positive regulation of mRNA cis splicing, via spliceosome, positive regulation of mRNA metabolic process, random inactivation of X chromosome, regulation of gene expression, regulation of telomere maintenance, regulation of translational termination, telomere maintenance via semi-conservative replication; MF: ATP binding, ATP hydrolysis activity, DNA binding, RNA binding, RNA helicase activity, chromatin binding, double-stranded DNA helicase activity, helicase activity, hydrolase activity, metal ion binding, nucleotide binding, protein binding, protein-containing complex binding, telomeric DNA binding, zinc ion binding; CC: P-body, chromatin, chromosome, telomeric region, cytoplasm, cytosol, exon-exon junction complex, nucleoplasm, nucleus, perinuclear region of cytoplasm, supraspliceosomal complex
Pathways: Metabolism of RNA, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), Nucleocytoplasmic transport - Mus musculus (mouse), mRNA surveillance pathway - Mus musculus (mouse)
UniProt: Q9EPU0
Entrez ID: 19704
|
Does Knockout of Gpnmb in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Gpnmb
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Gpnmb (glycoprotein (transmembrane) nmb)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: bone mineralization, cell adhesion, cell-cell signaling, negative regulation of G1/S transition of mitotic cell cycle, negative regulation of T cell activation, negative regulation of T cell proliferation, negative regulation of cytokine production, negative regulation of tumor necrosis factor production, osteoblast differentiation, positive regulation of ERK1 and ERK2 cascade, positive regulation of cell migration, regulation of tissue remodeling, signal transduction; MF: heparin binding, integrin binding, receptor ligand activity, syndecan binding; CC: cytoplasmic vesicle, early endosome membrane, endosome, melanosome membrane, membrane, plasma membrane
Pathways: PTK6 promotes HIF1A stabilization, Signal Transduction, Signaling by Non-Receptor Tyrosine Kinases, Signaling by PTK6
UniProt: Q99P91
Entrez ID: 93695
|
Does Knockout of Klra10 in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Klra10
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Klra10 (killer cell lectin-like receptor subfamily A, member 10)
Type: protein-coding
Summary: Predicted to enable signaling receptor activity. Predicted to be located in plasma membrane. Predicted to be active in cell surface. [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: MF: carbohydrate binding, signaling receptor activity; CC: cell surface, membrane, plasma membrane
Pathways:
UniProt: Q9R1G6
Entrez ID: 16628
|
Does Knockout of Mterf3 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,289
|
Knockout
|
Mterf3
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Mterf3 (mitochondrial transcription termination factor 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial ribosome assembly, negative regulation of DNA-templated transcription, regulation of DNA-templated transcription, regulation of mitochondrial transcription, ribosome biogenesis; MF: DNA binding, nucleic acid binding, transcription cis-regulatory region binding; CC: cytosol, mitochondrial matrix, mitochondrion
Pathways: Autophagy, Macroautophagy, Mitophagy, PINK1-PRKN Mediated Mitophagy, Selective autophagy
UniProt: Q8R3J4
Entrez ID: 66410
|
Does Knockout of Pde6a in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 2,477
|
Knockout
|
Pde6a
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Pde6a (phosphodiesterase 6A, cGMP-specific, rod, alpha)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of cAMP/PKA signal transduction, photoreceptor cell maintenance, retina development in camera-type eye, signal transduction, visual perception; MF: 3',5'-cyclic-AMP phosphodiesterase activity, 3',5'-cyclic-GMP phosphodiesterase activity, 3',5'-cyclic-nucleotide phosphodiesterase activity, hydrolase activity, metal ion binding, phosphoric diester hydrolase activity; CC: cell projection, membrane, photoreceptor outer segment, photoreceptor outer segment membrane, plasma membrane
Pathways: Phototransduction - Mus musculus (mouse), Purine metabolism - Mus musculus (mouse), cyclic GMP biosynthesis
UniProt: F6UDG9, Q8K0A8
Entrez ID: 225600
|
Does Knockout of Rpl31-ps12 in Acute Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 684
|
Knockout
|
Rpl31-ps12
|
cell proliferation
|
Acute Myeloid Leukemia Cell Line
|
Gene: Rpl31-ps12 (ribosomal protein L31, pseudogene 1 2)
Type: protein-coding
Summary: ribosomal protein L31, pseudogene 1 2
Gene Ontology:
Pathways: Coronavirus disease - COVID-19 - Mus musculus (mouse), Ribosome - Mus musculus (mouse)
UniProt:
Entrez ID: 665562
|
Does Knockout of Sec63 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,271
|
Knockout
|
Sec63
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Sec63 (SEC63 homolog, protein translocation regulator)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: SRP-dependent cotranslational protein targeting to membrane, liver development, nitrogen cycle metabolic process, post-translational protein targeting to endoplasmic reticulum membrane, post-translational protein targeting to membrane, translocation, protein transport; CC: Sec62/Sec63 complex, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Protein export - Mus musculus (mouse), Protein processing in endoplasmic reticulum - Mus musculus (mouse)
UniProt: Q8VHE0
Entrez ID: 140740
|
Does Knockout of Tpd52l2 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Tpd52l2
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Tpd52l2 (tumor protein D52-like 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: molecular_function, protein homodimerization activity; CC: cytoplasm, perinuclear region of cytoplasm
Pathways:
UniProt: Q9CYZ2
Entrez ID: 66314
|
Does Knockout of Gak in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Gak
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Gak (cyclin G associated kinase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi organization, Golgi to lysosome transport, clathrin coat assembly, clathrin coat disassembly, clathrin-dependent endocytosis, endoplasmic reticulum organization, epidermal cell differentiation, epithelial cell development, establishment of skin barrier, forebrain morphogenesis, intracellular transport, intrahepatic bile duct development, keratinocyte differentiation, negative regulation of neuron projection development, neuroepithelial cell differentiation, positive regulation of neural precursor cell proliferation, protein localization to Golgi apparatus, protein localization to plasma membrane, receptor-mediated endocytosis, regulation of clathrin coat assembly, stem cell differentiation; MF: ATP binding, clathrin binding, cyclin binding, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: Golgi apparatus, anchoring junction, clathrin-coated vesicle, cytoplasm, cytoplasmic vesicle, focal adhesion, intracellular membrane-bounded organelle, perinuclear region of cytoplasm, vesicle
Pathways: Clathrin-mediated endocytosis, Golgi Associated Vesicle Biogenesis, Membrane Trafficking, Vesicle-mediated transport, trans-Golgi Network Vesicle Budding
UniProt: Q99KY4
Entrez ID: 231580
|
Does Knockout of Khnyn in Immortal mouse chromaffin cells causally result in cell viability?
| 0
| 2,469
|
Knockout
|
Khnyn
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Khnyn (KH and NYN domain containing)
Type: protein-coding
Summary: This gene encodes a protein with a C-terminal RNA modifying domain that belongs to a family of ribonucleases typified by eukaryotic Nedd4-binding protein1 and the bacterial YacP-like nucleases (NYN). The NYN domain shares a common protein fold with two other groups of nucleases, the PilT N-terminal nuclease and FLAP nuclease superfamilies. In addition to the NYN domain, the protein encoded by this gene also contains an N-terminal K homology RNA-binding domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016].
Gene Ontology: MF: RNA endonuclease activity, mRNA binding; CC: cytoplasmic ribonucleoprotein granule, nucleus
Pathways:
UniProt: Q80U38
Entrez ID: 219094
|
Does Knockout of Etl4 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Etl4
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Etl4 (enhancer trap locus 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: centrosome, cytoplasm, cytoskeleton
Pathways:
UniProt: A2AQ25
Entrez ID: 208618
|
Does Knockout of Kcng2 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 1
| 2,174
|
Knockout
|
Kcng2
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Kcng2 (potassium voltage-gated channel, subfamily G, member 2)
Type: protein-coding
Summary: Predicted to enable potassium channel regulator activity. Predicted to be involved in action potential and potassium ion transmembrane transport. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in membrane. Orthologous to human KCNG2 (potassium voltage-gated channel modifier subfamily G member 2). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: action potential, monoatomic ion transmembrane transport, monoatomic ion transport, potassium ion transmembrane transport, potassium ion transport, protein homooligomerization, regulation of potassium ion transport, transmembrane transport; MF: monoatomic ion channel activity, potassium channel activity, potassium channel regulator activity, voltage-gated potassium channel activity; CC: membrane, monoatomic ion channel complex, plasma membrane, voltage-gated potassium channel complex
Pathways: Glucagon-like Peptide-1 (GLP1) regulates insulin secretion, Integration of energy metabolism, Metabolism, Neuronal System, Potassium Channels, Regulation of insulin secretion, Voltage gated Potassium channels
UniProt: V9GXB3, F7A6P6, V9GX03
Entrez ID: 240444
|
Does Knockout of Cachd1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Cachd1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Cachd1 (cache domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: calcium ion transmembrane transport, calcium ion transport, monoatomic ion transport; CC: membrane, voltage-gated calcium channel complex
Pathways:
UniProt: Q6PDJ1
Entrez ID: 320508
|
Does Knockout of Cebpz in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Cebpz
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Cebpz (CCAAT/enhancer binding protein zeta)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: CCAAT-binding factor complex, nucleoplasm, nucleus
Pathways:
UniProt: P53569
Entrez ID: 12607
|
Does Knockout of Rhd in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
Rhd
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Rhd (Rh blood group, D antigen)
Type: protein-coding
Summary: Predicted to enable ammonium channel activity. Acts upstream of or within ammonium transmembrane transport; erythrocyte development; and multicellular organismal-level iron ion homeostasis. Located in membrane. Is expressed in several structures, including gonad; heart; liver; lung; and spleen. Human ortholog(s) of this gene implicated in Rh isoimmunization. Orthologous to several human genes including RHD (Rh blood group D antigen). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: ammonium homeostasis, ammonium transmembrane transport, erythrocyte development, multicellular organismal-level iron ion homeostasis; MF: ammonium channel activity; CC: ankyrin-1 complex, membrane, plasma membrane
Pathways:
UniProt: Q8CF94
Entrez ID: 19746
|
Does Knockout of Pknox2 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Pknox2
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Pknox2 (Pbx/knotted 1 homeobox 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, actin filament binding, actin monomer binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: actin cytoskeleton, cytoplasm, intercellular bridge, microtubule cytoskeleton, nucleoplasm, nucleus
Pathways:
UniProt: Q8BG99
Entrez ID: 208076
|
Does Knockout of Polr2m in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Polr2m
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Polr2m (polymerase (RNA) II (DNA directed) polypeptide M)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: maintenance of ER location, transcription elongation by RNA polymerase II; MF: RNA polymerase II complex binding, molecular_function, transcription elongation factor activity; CC: DNA-directed RNA polymerase complex, I band, RNA polymerase II, core complex, neuronal cell body, nuclear envelope, nucleus, transcription preinitiation complex
Pathways:
UniProt: Q6P6I6
Entrez ID: 28015
|
Does Knockout of Esco2 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Esco2
|
phagocytosis
|
macrophage
|
Gene: Esco2 (establishment of sister chromatid cohesion N-acetyltransferase 2)
Type: protein-coding
Summary: Enables L-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor. Acts upstream of or within several processes, including double-strand break repair; hematopoietic progenitor cell differentiation; and protein localization to chromatin. Located in chromocenter and chromosome. Is expressed in several structures, including alimentary system; brain; gonad; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in Roberts syndrome and lung adenocarcinoma. Orthologous to human ESCO2 (establishment of sister chromatid cohesion N-acetyltransferase 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: chromosome segregation, double-strand break repair, hematopoietic progenitor cell differentiation, mitotic sister chromatid cohesion, protein localization to chromatin, regulation of DNA replication; MF: L-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor, acetyltransferase activity, acyltransferase activity, metal ion binding, protein-lysine-acetyltransferase activity, transferase activity, zinc ion binding; CC: Golgi apparatus, XY body, cell junction, chromatin, chromocenter, chromosome, nucleoplasm, nucleus, pericentric heterochromatin, site of double-strand break
Pathways: Cell Cycle, Cell Cycle, Mitotic, Establishment of Sister Chromatid Cohesion, S Phase
UniProt: Q8CIB9
Entrez ID: 71988
|
Does Knockout of Rnf111 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Rnf111
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Rnf111 (ring finger 111)
Type: protein-coding
Summary: Enables ubiquitin protein ligase activity. Acts upstream of or within several processes, including positive regulation of protein ubiquitination; positive regulation of transforming growth factor beta receptor signaling pathway; and protein polyubiquitination. Located in cytoplasm and nucleus. Part of protein-containing complex. Is expressed in several structures, including heart; nervous system; testis; and urinary system. Orthologous to human RNF111 (ring finger protein 111). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: DNA damage response, DNA repair, pattern specification process, positive regulation of protein ubiquitination, positive regulation of transforming growth factor beta receptor signaling pathway, protein polyubiquitination, protein ubiquitination, ubiquitin-dependent protein catabolic process; MF: SMAD binding, SUMO polymer binding, metal ion binding, protein binding, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: PML body, cytoplasm, cytosol, nucleoplasm, nucleus, protein-containing complex
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, DNA Repair, Formation of Incision Complex in GG-NER, Gene expression (Transcription), Generic Transcription Pathway, Global Genome Nucleotide Excision Repair (GG-NER), Immune System, Nucleotide Excision Repair, RNA Polymerase II Transcription, SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription, Signal Transduction, Signaling by TGF-beta Receptor Complex, Signaling by TGFB family members, Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
UniProt: Q99ML9
Entrez ID: 93836
|
Does Knockout of Hnrnpf in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Hnrnpf
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Hnrnpf (heterogeneous nuclear ribonucleoprotein F)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, mRNA processing, regulation of RNA splicing; MF: RNA binding, TBP-class protein binding, nucleic acid binding, single-stranded RNA binding; CC: catalytic step 2 spliceosome, cytosol, nucleoplasm, nucleus, ribonucleoprotein complex, spliceosomal complex, synapse
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q9Z2X1
Entrez ID: 98758
|
Does Knockout of Babam2 in Acute Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 684
|
Knockout
|
Babam2
|
cell proliferation
|
Acute Myeloid Leukemia Cell Line
|
Gene: Babam2 (BRISC and BRCA1 A complex member 2)
Type: protein-coding
Summary: Enables tumor necrosis factor receptor binding activity. Predicted to be involved in several processes, including cellular response to ionizing radiation; mitotic G2 DNA damage checkpoint signaling; and positive regulation of DNA repair. Predicted to be located in cytosol and nucleus. Predicted to be part of BRCA1-A complex; BRISC complex; and nuclear ubiquitin ligase complex. Is expressed in central nervous system and retina. Orthologous to human BABAM2 (BRISC and BRCA1 A complex member 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: DNA damage response, DNA repair, apoptotic process, cell division, cellular response to ionizing radiation, chromatin organization, double-strand break repair, mitotic G2 DNA damage checkpoint signaling, mitotic G2/M transition checkpoint, negative regulation of apoptotic process, positive regulation of DNA repair, regulation of DNA damage checkpoint, regulation of DNA repair, response to ionizing radiation; MF: polyubiquitin modification-dependent protein binding, tumor necrosis factor receptor binding; CC: BRCA1-A complex, BRISC complex, cytoplasm, cytosol, nuclear ubiquitin ligase complex, nucleus
Pathways: Cell Cycle, Cell Cycle Checkpoints, DNA Double Strand Break Response, DNA Double-Strand Break Repair, DNA Repair, Deubiquitination, G2/M Checkpoints, G2/M DNA damage checkpoint, HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homologous recombination - Mus musculus (mouse), Homology Directed Repair, Metabolism of proteins, Metalloprotease DUBs, Nonhomologous End-Joining (NHEJ), Post-translational protein modification, Processing of DNA double-strand break ends, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
UniProt: Q8K3W0
Entrez ID: 107976
|
Does Knockout of Crtap in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Crtap
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Crtap (cartilage associated protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: collagen fibril organization, negative regulation of post-translational protein modification, protein folding, protein stabilization, spermatogenesis; MF: collagen binding, protein binding; CC: endoplasmic reticulum, extracellular region, extracellular space, protein-containing complex
Pathways:
UniProt: Q9CYD3
Entrez ID: 56693
|
Does Knockout of Cd44 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,157
|
Knockout
|
Cd44
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Cd44 (CD44 antigen)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell activation, Wnt signaling pathway, anatomical structure morphogenesis, branching involved in prostate gland morphogenesis, branching involved in ureteric bud morphogenesis, cell adhesion, cell migration, cellular response to fibroblast growth factor stimulus, cytokine-mediated signaling pathway, hyaluronan catabolic process, inflammatory response, macrophage fusion, monocyte aggregation, negative regulation of CD4-positive, alpha-beta T cell proliferation, negative regulation of DNA damage response, signal transduction by p53 class mediator, negative regulation of apoptotic process, negative regulation of inflammatory response, negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, negative regulation of mature B cell apoptotic process, negative regulation of regulatory T cell differentiation, neuron projection development, positive regulation of ERK1 and ERK2 cascade, positive regulation of adaptive immune response, positive regulation of gene expression, positive regulation of heterotypic cell-cell adhesion, positive regulation of monocyte aggregation, positive regulation of neutrophil apoptotic process, postsynapse organization, receptor-mediated endocytosis, regulation of cell growth, regulation of lamellipodium morphogenesis, regulation of leukocyte apoptotic process, regulation of modification of postsynaptic structure, system development, wound healing involved in inflammatory response, wound healing, spreading of cells; MF: cargo receptor activity, channel regulator activity, cytokine binding, cytokine receptor activity, epidermal growth factor receptor binding, hyaluronic acid binding, phosphoprotein binding, protein binding, protein kinase binding, transmembrane signaling receptor activity, type II transforming growth factor beta receptor binding; CC: Golgi apparatus, apical plasma membrane, basolateral plasma membrane, cell projection, cell surface, cytosol, external side of plasma membrane, extracellular region, glutamatergic synapse, lamellipodium membrane, macrophage migration inhibitory factor receptor complex, membrane, membrane raft, microvillus, plasma membrane, postsynapse, presynapse, protein-containing complex
Pathways: Cell surface interactions at the vascular wall, Degradation of the extracellular matrix, ECM-receptor interaction - Mus musculus (mouse), Epstein-Barr virus infection - Mus musculus (mouse), Extracellular matrix organization, Glycosaminoglycan metabolism, Hematopoietic cell lineage - Mus musculus (mouse), Hemostasis, Hyaluronan degradation, Hyaluronan metabolism, Immune System, Innate Immune System, Integrin cell surface interactions, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, MicroRNAs in cancer - Mus musculus (mouse), Neutrophil degranulation, Proteoglycans in cancer - Mus musculus (mouse)
UniProt: P15379
Entrez ID: 12505
|
Does Knockout of Rcor1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 2,477
|
Knockout
|
Rcor1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Rcor1 (REST corepressor 1)
Type: protein-coding
Summary: Enables chromatin binding activity; enzyme binding activity; and transcription corepressor activity. Involved in erythrocyte differentiation; negative regulation of gene expression; and positive regulation of megakaryocyte differentiation. Predicted to be located in nucleoplasm. Predicted to be part of DNA repair complex; histone deacetylase complex; and transcription repressor complex. Is expressed in several structures, including brain; early embryo; extraembryonic component; liver; and nose. Orthologous to human RCOR1 (REST corepressor 1). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: chromatin organization, erythrocyte differentiation, negative regulation of DNA-templated transcription, negative regulation of gene expression, positive regulation of megakaryocyte differentiation, regulation of transcription by RNA polymerase II; MF: chromatin binding, enzyme binding, protein binding, transcription corepressor activity; CC: DNA repair complex, histone deacetylase complex, histone methyltransferase complex, nucleoplasm, nucleus, transcription regulator complex, transcription repressor complex
Pathways: Chromatin modifying enzymes, Chromatin organization, Factors involved in megakaryocyte development and platelet production, HDACs deacetylate histones, Hemostasis, Huntington disease - Mus musculus (mouse)
UniProt: Q8CFE3
Entrez ID: 217864
|
Does Knockout of Prss34 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Prss34
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Prss34 (serine protease 34)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: proteolysis; MF: glycosaminoglycan binding, heparin binding, hydrolase activity, peptidase activity, serine-type endopeptidase activity, serine-type peptidase activity; CC: extracellular matrix, extracellular space
Pathways:
UniProt: A0AAA9WVZ7, Q80UR4
Entrez ID: 328780
|
Does Knockout of Rps7 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Rps7
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Rps7 (ribosomal protein S7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translation, negative regulation of ubiquitin-dependent protein catabolic process, neural crest cell differentiation, neural tube closure, positive regulation of gene expression, positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator, protein stabilization, rRNA processing, ribosomal small subunit biogenesis, translation; MF: mRNA 3'-UTR binding, mRNA 5'-UTR binding, poly(U) RNA binding, protein kinase binding, structural constituent of ribosome, ubiquitin ligase inhibitor activity; CC: centrosome, cytoplasm, cytoskeleton, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, endoplasmic reticulum, nucleolus, nucleus, postsynapse, protein-containing complex, ribonucleoprotein complex, ribosome, small-subunit processome, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosomal scanning and start codon recognition, Ribosome - Mus musculus (mouse), Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, Translation initiation complex formation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62082
Entrez ID: 20115
|
Does Knockout of Tas2r103 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Tas2r103
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Tas2r103 (taste receptor, type 2, member 103)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, detection of chemical stimulus involved in sensory perception of bitter taste, detection of chemical stimulus involved in sensory perception of taste, sensory perception of bitter taste, sensory perception of taste, signal transduction; MF: G protein-coupled receptor activity, bitter taste receptor activity, taste receptor activity; CC: membrane
Pathways: Taste transduction - Mus musculus (mouse)
UniProt: Q9JKA3
Entrez ID: 667992
|
Does Knockout of Tmem39a in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Tmem39a
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Tmem39a (transmembrane protein 39a)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagy, negative regulation of autophagosome assembly, negative regulation of autophagosome maturation, positive regulation of viral genome replication; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways:
UniProt: Q9CYC3
Entrez ID: 67846
|
Does Knockout of Pgm5 in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Pgm5
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Pgm5 (phosphoglucomutase 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: carbohydrate metabolic process, cell adhesion, myofibril assembly, striated muscle tissue development; MF: magnesium ion binding, phosphoglucomutase activity, protein binding; CC: Z disc, adherens junction, anchoring junction, cell-substrate junction, costamere, cytoplasm, cytoplasmic side of plasma membrane, cytoskeleton, cytosol, dystrophin-associated glycoprotein complex, focal adhesion, intercalated disc, membrane, plasma membrane, sarcolemma, spot adherens junction, stress fiber
Pathways: GDP-glucose biosynthesis, UDP-glucose conversion, glucose and glucose-1-phosphate degradation, glycogen degradation II, glycogen degradation III, starch degradation
UniProt: Q8BZF8
Entrez ID: 226041
|
Does Knockout of Rprd1b in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Rprd1b
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Rprd1b (regulation of nuclear pre-mRNA domain containing 1B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA polymerase II promoter clearance, mRNA 3'-end processing, positive regulation of cell population proliferation, positive regulation of transcription by RNA polymerase II, regulation of cell cycle process; MF: RNA polymerase II C-terminal domain binding, RNA polymerase II complex binding, identical protein binding; CC: nucleoplasm, nucleus, transcription preinitiation complex
Pathways: Gene expression (Transcription), RNA Polymerase II Transcription, RNA polymerase II transcribes snRNA genes
UniProt: Q9CSU0
Entrez ID: 70470
|
Does Knockout of Clec3a in Regulatory T cell causally result in cell proliferation?
| 0
| 2,127
|
Knockout
|
Clec3a
|
cell proliferation
|
Regulatory T cell
|
Gene: Clec3a (C-type lectin domain family 3, member a)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: extracellular region, extracellular space
Pathways:
UniProt: Q9EPW4
Entrez ID: 403395
|
Does Knockout of Btnl9 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Btnl9
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Btnl9 (butyrophilin-like 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell receptor signaling pathway, regulation of cytokine production; CC: external side of plasma membrane, membrane
Pathways: Adaptive Immune System, Butyrophilin (BTN) family interactions, Immune System
UniProt: Q8BJE2
Entrez ID: 237754
|
Does Knockout of Ssty1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Ssty1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Ssty1 (spermiogenesis specific transcript on the Y 1)
Type: protein-coding
Summary: Predicted to enable methylated histone binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be active in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: gamete generation, regulation of DNA-templated transcription; CC: cytosol, nucleoplasm
Pathways:
UniProt: P13675
Entrez ID: 20611
|
Does Knockout of Gpi1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Gpi1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Gpi1 (glucose-6-phosphate isomerase 1)
Type: protein-coding
Summary: This gene encodes a member of the glucose phosphate isomerase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In the cytoplasm, the gene product functions as a glycolytic enzyme (glucose-6-phosphate isomerase) that interconverts glucose-6-phosphate and fructose-6-phosphate. Extracellularly, the encoded protein (also referred to as neuroleukin) functions as a neurotrophic factor that promotes survival of skeletal motor neurons and sensory neurons, and as a lymphokine that induces immunoglobulin secretion. The encoded protein is also referred to as autocrine motility factor based on an additional function as a tumor-secreted cytokine and angiogenic factor. [provided by RefSeq, Aug 2016].
Gene Ontology: BP: canonical glycolysis, carbohydrate derivative metabolic process, erythrocyte homeostasis, fructose 6-phosphate metabolic process, gluconeogenesis, glucose 6-phosphate metabolic process, glucose homeostasis, glycolytic process, glycolytic process through glucose-6-phosphate, in utero embryonic development, learning or memory, mesoderm formation, negative regulation of apoptotic process, negative regulation of glycolytic process through fructose-6-phosphate, positive regulation of endothelial cell migration, positive regulation of glycolytic process through fructose-6-phosphate, positive regulation of immunoglobulin production, response to cadmium ion, response to estradiol, response to immobilization stress, response to muscle stretch, response to progesterone, response to testosterone, signal transduction; MF: carbohydrate derivative binding, cytokine activity, glucose-6-phosphate isomerase activity, growth factor activity, isomerase activity, monosaccharide binding, protein binding, racemase and epimerase activity, acting on carbohydrates and derivatives, ubiquitin protein ligase binding; CC: ciliary membrane, cytoplasm, cytosol, extracellular region, extracellular space, myelin sheath, plasma membrane
Pathways: Amino sugar and nucleotide sugar metabolism - Mus musculus (mouse), GDP-mannose biosynthesis, GDP-mannose biosynthesis I, Gene expression (Transcription), Generic Transcription Pathway, Gluconeogenesis, Glucose metabolism, Glycolysis, Glycolysis / Gluconeogenesis - Mus musculus (mouse), Immune System, Innate Immune System, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Neutrophil degranulation, Pentose phosphate pathway - Mus musculus (mouse), RNA Polymerase II Transcription, Starch and sucrose metabolism - Mus musculus (mouse), TP53 Regulates Metabolic Genes, Transcriptional Regulation by TP53, colanic acid building blocks biosynthesis, formaldehyde oxidation I, gluconeogenesis I, glycolysis I, glycolysis III, glycolysis V (Pyrococcus), sucrose degradation
UniProt: P06745
Entrez ID: 14751
|
Does Knockout of Lonp1 in Regulatory T cell causally result in cell proliferation?
| 0
| 2,127
|
Knockout
|
Lonp1
|
cell proliferation
|
Regulatory T cell
|
Gene: Lonp1 (lon peptidase 1, mitochondrial)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to oxidative stress, chaperone-mediated protein complex assembly, mitochondrial protein catabolic process, mitochondrion organization, negative regulation of insulin receptor signaling pathway, oxidation-dependent protein catabolic process, protein catabolic process, protein quality control for misfolded or incompletely synthesized proteins, protein-containing complex assembly, proteolysis, proteolysis involved in protein catabolic process, response to aluminum ion, response to hormone, response to hypoxia; MF: ADP binding, ATP binding, ATP hydrolysis activity, ATP-dependent peptidase activity, DNA binding, DNA polymerase binding, G-quadruplex DNA binding, PH domain binding, hydrolase activity, identical protein binding, insulin receptor substrate binding, mitochondrial promoter sequence-specific DNA binding, nucleotide binding, peptidase activity, sequence-specific DNA binding, serine-type endopeptidase activity, serine-type peptidase activity, single-stranded DNA binding, single-stranded RNA binding; CC: cytosol, mitochondrial matrix, mitochondrial nucleoid, mitochondrion, nucleoplasm
Pathways: Metabolism of proteins, Mitochondrial protein degradation
UniProt: Q8CGK3
Entrez ID: 74142
|
Does Knockout of F2rl3 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
F2rl3
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: F2rl3 (F2R like thrombin or trypsin receptor 3)
Type: protein-coding
Summary: This gene encodes a member of the protease-activated receptor subfamily, part of the G-protein coupled receptor 1 family of proteins. The encoded receptor is proteolytically processed to reveal an extracellular N-terminal tethered ligand that binds to and activates the receptor. This receptor plays a role in blood coagulation, inflammation and response to pain. Mice lacking a functional copy of this gene exhibit impaired platelet activation and prolonged bleeding times. [provided by RefSeq, Sep 2016].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, blood coagulation, hemostasis, platelet activation, platelet aggregation, positive regulation of release of sequestered calcium ion into cytosol, signal transduction, thrombin-activated receptor signaling pathway; MF: G protein-coupled receptor activity, protease binding, thrombin-activated receptor activity; CC: membrane, plasma membrane
Pathways: Class A/1 (Rhodopsin-like receptors), Complement and coagulation cascades - Mus musculus (mouse), G alpha (q) signalling events, GPCR downstream signalling, GPCR ligand binding, Hemostasis, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Peptide ligand-binding receptors, Platelet activation - Mus musculus (mouse), Platelet activation, signaling and aggregation, Rap1 signaling pathway - Mus musculus (mouse), Signal Transduction, Signaling by GPCR, Thrombin signalling through proteinase activated receptors (PARs)
UniProt: O88634
Entrez ID: 14065
|
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