prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Alb in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Alb
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Alb (albumin)
Type: protein-coding
Summary: This gene encodes albumin, an abundant plasma protein essential for maintaining oncotic pressure that functions as a carrier protein for various molecules such as steriods and fatty acids in blood. This gene is primarily expressed in liver where the encoded protein undergoes proteolytic processing before secretion into the plasma. [provided by RefSeq, Oct 2015].
Gene Ontology: BP: bilirubin transport, cellular response to calcium ion starvation, cellular response to starvation, negative regulation of mitochondrial depolarization, positive regulation of circadian sleep/wake cycle, non-REM sleep, response to nutrient levels; MF: DNA binding, enterobactin binding, enzyme binding, exogenous protein binding, fatty acid binding, identical protein binding, lipid binding, metal ion binding, modified amino acid binding, molecular carrier activity, oxygen binding, protein-folding chaperone binding, pyridoxal phosphate binding, toxic substance binding, zinc ion binding; CC: Golgi apparatus, basement membrane, cytoplasm, endoplasmic reticulum, extracellular exosome, extracellular region, extracellular space, myelin sheath, protein-containing complex
Pathways: Aspirin ADME, Bile acid and bile salt metabolism, Binding and Uptake of Ligands by Scavenger Receptors, Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Ciprofloxacin ADME, Cytoprotection by HMOX1, Drug ADME, HDL remodeling, Heme biosynthesis, Heme degradation, Hemostasis, Metabolism, Metabolism of lipids, Metabolism of porphyrins, Metabolism of proteins, Metabolism of steroids, Plasma lipoprotein assembly, remodeling, and clearance, Plasma lipoprotein remodeling, Platelet activation, signaling and aggregation, Platelet degranulation , Post-translational protein modification, Post-translational protein phosphorylation, Prednisone ADME, Recycling of bile acids and salts, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Response to elevated platelet cytosolic Ca2+, Scavenging of heme from plasma, Thyroid hormone synthesis - Mus musculus (mouse), Transport of small molecules, Vesicle-mediated transport
UniProt: P07724
Entrez ID: 11657
|
Does Knockout of GM21893 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
GM21893
|
phagocytosis
|
macrophage
|
Gene: Gm21893 (predicted gene, 21893)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID:
|
Does Knockout of Gja6 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Gja6
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Gja6 (gap junction protein, alpha 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell communication, cell communication by electrical coupling, cell-cell signaling, heart development, transmembrane transport; CC: anchoring junction, connexin complex, gap junction, membrane, plasma membrane
Pathways:
UniProt: Q6S5G4
Entrez ID: 414089
|
Does Knockout of Foxj2 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Foxj2
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Foxj2 (forkhead box J2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, male meiosis I, meiotic cell cycle, negative regulation of angiogenesis, negative regulation of blood vessel endothelial cell differentiation, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, positive regulation of vascular associated smooth muscle cell proliferation, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, spermatogenesis; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, identical protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: fibrillar center, nucleoplasm, nucleus
Pathways:
UniProt: Q9ES18
Entrez ID: 60611
|
Does Knockout of Plcb4 in Embryonic Fibroblast Cell Line causally result in autophagy?
| 1
| 1,043
|
Knockout
|
Plcb4
|
autophagy
|
Embryonic Fibroblast Cell Line
|
Gene: Plcb4 (phospholipase C, beta 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intracellular signal transduction, lipid catabolic process, lipid metabolic process, modulation of chemical synaptic transmission, negative regulation of potassium ion transport, phosphatidylinositol metabolic process, phosphatidylinositol-mediated signaling, phospholipase C-activating endothelin receptor signaling pathway, release of sequestered calcium ion into cytosol, signal transduction; MF: calcium ion binding, hydrolase activity, metal ion binding, mitogen-activated protein kinase binding, phosphatidylinositol-4,5-bisphosphate phospholipase C activity, phosphoric diester hydrolase activity, protein binding; CC: dendrite, glutamatergic synapse, nucleus, parallel fiber to Purkinje cell synapse, plasma membrane, postsynapse, postsynaptic density, smooth endoplasmic reticulum
Pathways: AGE-RAGE signaling pathway in diabetic complications - Mus musculus (mouse), Adrenergic signaling in cardiomyocytes - Mus musculus (mouse), African trypanosomiasis - Mus musculus (mouse), Aldosterone synthesis and secretion - Mus musculus (mouse), Alzheimer disease - Mus musculus (mouse), Amoebiasis - Mus musculus (mouse), Apelin signaling pathway - Mus musculus (mouse), Calcium signaling pathway - Mus musculus (mouse), Carbohydrate digestion and absorption - Mus musculus (mouse), Chagas disease - Mus musculus (mouse), Chemokine signaling pathway - Mus musculus (mouse), Cholinergic synapse - Mus musculus (mouse), Circadian entrainment - Mus musculus (mouse), Cortisol synthesis and secretion - Mus musculus (mouse), Cushing syndrome - Mus musculus (mouse), Diabetic cardiomyopathy - Mus musculus (mouse), Dopaminergic synapse - Mus musculus (mouse), Endocrine and other factor-regulated calcium reabsorption - Mus musculus (mouse), Estrogen signaling pathway - Mus musculus (mouse), G alpha (i) signalling events, G alpha (q) signalling events, G-protein mediated events, GPCR downstream signalling, Gap junction - Mus musculus (mouse), Gastric acid secretion - Mus musculus (mouse), Glucagon signaling pathway - Mus musculus (mouse), Glutamatergic synapse - Mus musculus (mouse), GnRH secretion - Mus musculus (mouse), GnRH signaling pathway - Mus musculus (mouse), Growth hormone synthesis, secretion and action - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Inflammatory mediator regulation of TRP channels - Mus musculus (mouse), Inositol phosphate metabolism, Inositol phosphate metabolism - Mus musculus (mouse), Insulin secretion - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), Long-term depression - Mus musculus (mouse), Long-term potentiation - Mus musculus (mouse), Melanogenesis - Mus musculus (mouse), Metabolism, NOD-like receptor signaling pathway - Mus musculus (mouse), Neutrophil extracellular trap formation - Mus musculus (mouse), Opioid Signalling, Oxytocin signaling pathway - Mus musculus (mouse), PLC beta mediated events, Pancreatic secretion - Mus musculus (mouse), Parathyroid hormone synthesis, secretion and action - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Phosphatidylinositol signaling system - Mus musculus (mouse), Phospholipase D signaling pathway - Mus musculus (mouse), Platelet activation - Mus musculus (mouse), Rap1 signaling pathway - Mus musculus (mouse), Relaxin signaling pathway - Mus musculus (mouse), Renin secretion - Mus musculus (mouse), Retrograde endocannabinoid signaling - Mus musculus (mouse), Salivary secretion - Mus musculus (mouse), Serotonergic synapse - Mus musculus (mouse), Signal Transduction, Signaling by GPCR, Sphingolipid signaling pathway - Mus musculus (mouse), Spinocerebellar ataxia - Mus musculus (mouse), Synthesis of IP3 and IP4 in the cytosol, Taste transduction - Mus musculus (mouse), Thyroid hormone signaling pathway - Mus musculus (mouse), Thyroid hormone synthesis - Mus musculus (mouse), Vascular smooth muscle contraction - Mus musculus (mouse), Wnt signaling pathway - Mus musculus (mouse), cGMP-PKG signaling pathway - Mus musculus (mouse)
UniProt: A2AT93, Q91UZ1, A2AT91, V9GXQ9
Entrez ID: 18798
|
Does Knockout of Kank4 in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Kank4
|
cell cycle progression
|
breast epithelium
|
Gene: Kank4 (KN motif and ankyrin repeat domains 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of actin filament polymerization, negative regulation of stress fiber assembly; CC: cytoplasm, cytoskeleton, cytosol, microtubule cytoskeleton
Pathways:
UniProt: Q6P9J5
Entrez ID: 242553
|
Does Knockout of Rhbdd2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Rhbdd2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Rhbdd2 (rhomboid domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: serine-type endopeptidase activity; CC: Golgi apparatus, Golgi membrane, membrane, nucleoplasm, perinuclear region of cytoplasm
Pathways:
UniProt: Q8VEK2
Entrez ID: 215160
|
Does Knockout of Cd99l2 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Cd99l2
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Cd99l2 (CD99 antigen-like 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, diapedesis, homotypic cell-cell adhesion, positive regulation of T cell extravasation, positive regulation of neutrophil extravasation; CC: adherens junction, anchoring junction, cell surface, extracellular region, membrane, plasma membrane
Pathways: Cell adhesion molecules - Mus musculus (mouse), Leukocyte transendothelial migration - Mus musculus (mouse)
UniProt: Q8BIF0
Entrez ID: 171486
|
Does Knockout of Lipo4 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Lipo4
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Lipo4 (lipase, member O4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, lipid catabolic process, lipid metabolic process, sterol metabolic process; MF: hydrolase activity, hydrolase activity, acting on ester bonds, molecular_function, sterol ester esterase activity; CC: cellular_component, intracellular membrane-bounded organelle
Pathways:
UniProt: F6RR30
Entrez ID: 628236
|
Does Knockout of Oca2 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Oca2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Oca2 (oculocutaneous albinism II)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell population proliferation, chloride transmembrane transport, developmental pigmentation, lysosomal lumen pH elevation, melanin biosynthetic process, melanin biosynthetic process from tyrosine, melanocyte differentiation, pigmentation, spermatid development, transmembrane transport; MF: chloride channel activity; CC: endoplasmic reticulum membrane, endosome membrane, lysosomal membrane, melanosome membrane, membrane
Pathways: Melanin biosynthesis, Metabolism, Metabolism of amino acids and derivatives
UniProt: Q62052
Entrez ID: 18431
|
Does Knockout of Lipa in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Lipa
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Lipa (lysosomal acid lipase A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ATP biosynthetic process, T cell apoptotic process, T cell differentiation, T cell proliferation, TOR signaling, acute inflammatory response, adaptive thermogenesis, adipose tissue development, blood vessel endothelial cell differentiation, bone marrow development, cell morphogenesis, cell population proliferation, cell proliferation in bone marrow, cholesterol biosynthetic process, cholesterol efflux, cholesterol metabolic process, cholesterol storage, cholesterol transport, common myeloid progenitor cell proliferation, defecation, determination of adult lifespan, endocytosis, endosome to lysosome transport, endothelial cell proliferation, energy homeostasis, epithelial cell proliferation, fat cell proliferation, fatty acid metabolic process, gene expression, glucose metabolic process, glycolytic process, hematopoietic progenitor cell differentiation, hemopoiesis, homeostasis of number of cells, homeostasis of number of cells within a tissue, inflammatory response, lipid biosynthetic process, lipid catabolic process, lipid homeostasis, lipid import into cell, lipid metabolic process, lipid storage, lipoprotein catabolic process, liver development, liver morphogenesis, lung development, lysosome organization, macrophage homeostasis, mitochondrion organization, mitotic cell cycle, multicellular organismal-level chemical homeostasis, multicellular organismal-level homeostasis, myeloid cell apoptotic process, myeloid cell differentiation, neutral lipid metabolic process, positive regulation of T cell receptor signaling pathway, programmed cell death, reactive oxygen species biosynthetic process, regulation of membrane potential, regulation of mitochondrial membrane potential, respiratory burst involved in inflammatory response, response to cold, response to dietary excess, response to lipid, response to rapamycin, response to vitamin A, response to xenobiotic stimulus, retinoid metabolic process, small GTPase-mediated signal transduction, spleen development, sterol metabolic process, tissue remodeling, triglyceride metabolic process, triglyceride-rich lipoprotein particle clearance, vitamin A metabolic process; MF: hydrolase activity, hydrolase activity, acting on ester bonds, lipase activity, sterol ester esterase activity; CC: cytosol, fibrillar center, intracellular membrane-bounded organelle, lysosome, nucleoplasm
Pathways: Cholesterol metabolism - Mus musculus (mouse), LDL clearance, Lysosome - Mus musculus (mouse), Plasma lipoprotein assembly, remodeling, and clearance, Plasma lipoprotein clearance, Steroid biosynthesis - Mus musculus (mouse), Transport of small molecules
UniProt: Q9Z0M5
Entrez ID: 16889
|
Does Knockout of Ccl26 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Ccl26
|
phagocytosis
|
macrophage
|
Gene: Ccl26 (C-C motif chemokine ligand 26)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell chemotaxis, antimicrobial humoral immune response mediated by antimicrobial peptide, chemokine-mediated signaling pathway, chemotaxis, eosinophil chemotaxis, immune response, inflammatory response, monocyte chemotaxis, positive regulation of actin filament polymerization, positive regulation of cell migration, positive regulation of chemotaxis, positive regulation of endothelial cell proliferation; MF: CCR chemokine receptor binding, CCR3 chemokine receptor binding, CX3C chemokine receptor binding, chemokine activity, cytokine activity, receptor ligand activity; CC: extracellular region, extracellular space
Pathways: Chemokine signaling pathway - Mus musculus (mouse), Cytokine-cytokine receptor interaction - Mus musculus (mouse), Viral protein interaction with cytokine and cytokine receptor - Mus musculus (mouse)
UniProt: F8VQM2
Entrez ID: 541307
|
Does Knockout of Tbp in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Tbp
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Tbp (TATA box binding protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA-templated transcription initiation, RNA polymerase I preinitiation complex assembly, RNA polymerase II preinitiation complex assembly, mRNA transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of transcription initiation by RNA polymerase II, transcription by RNA polymerase II, transcription by RNA polymerase III; MF: DNA binding, DNA-binding transcription factor binding, RNA polymerase I core promoter sequence-specific DNA binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II core promoter sequence-specific DNA binding, RNA polymerase II general transcription initiation factor activity, RNA polymerase II general transcription initiation factor binding, RNA polymerase II-specific DNA-binding transcription factor binding, RNA polymerase III general transcription initiation factor activity, TFIIB-class transcription factor binding, aryl hydrocarbon receptor binding, core promoter sequence-specific DNA binding, enzyme binding, protein binding, transcription cis-regulatory region binding; CC: RNA polymerase I transcription regulator complex, RNA polymerase transcription factor SL1 complex, chromatin, cytoplasm, cytosol, euchromatin, female germ cell nucleus, female pronucleus, male germ cell nucleus, male pronucleus, nucleoplasm, nucleus, pronucleus, protein-containing complex, transcription factor TFIIA complex, transcription factor TFIID complex
Pathways: B-WICH complex positively regulates rRNA expression, Basal transcription factors - Mus musculus (mouse), ESR-mediated signaling, Epigenetic regulation of gene expression, Estrogen-dependent gene expression, Gene expression (Transcription), Generic Transcription Pathway, Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Positive epigenetic regulation of rRNA expression, RNA Polymerase I Promoter Clearance, RNA Polymerase I Promoter Escape, RNA Polymerase I Transcription, RNA Polymerase I Transcription Initiation, RNA Polymerase I Transcription Termination, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Promoter Escape, RNA Polymerase II Transcription, RNA Polymerase II Transcription Initiation, RNA Polymerase II Transcription Initiation And Promoter Clearance, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, RNA Polymerase III Transcription, RNA Polymerase III Transcription Initiation, RNA Polymerase III Transcription Initiation From Type 1 Promoter, RNA Polymerase III Transcription Initiation From Type 2 Promoter, RNA Polymerase III Transcription Initiation From Type 3 Promoter, RNA polymerase II transcribes snRNA genes, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Signal Transduction, Signaling by Nuclear Receptors, Spinocerebellar ataxia - Mus musculus (mouse), Transcriptional Regulation by TP53, Viral carcinogenesis - Mus musculus (mouse)
UniProt: P29037
Entrez ID: 21374
|
Does Knockout of Snapc5 in Microglial Cell Line causally result in response to virus?
| 1
| 1,438
|
Knockout
|
Snapc5
|
response to virus
|
Microglial Cell Line
|
Gene: Snapc5 (small nuclear RNA activating complex, polypeptide 5)
Type: protein-coding
Summary: Predicted to enable RNA polymerase II general transcription initiation factor activity and RNA polymerase III general transcription initiation factor activity. Predicted to be involved in snRNA transcription by RNA polymerase II; snRNA transcription by RNA polymerase III; and transcription initiation at RNA polymerase III promoter. Predicted to be located in nuclear body and nucleolus. Is expressed in genitourinary system. Orthologous to human SNAPC5 (small nuclear RNA activating complex polypeptide 5). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: snRNA transcription by RNA polymerase II, snRNA transcription by RNA polymerase III, transcription by RNA polymerase II, transcription initiation at RNA polymerase III promoter; MF: RNA polymerase II general transcription initiation factor activity, RNA polymerase III general transcription initiation factor activity; CC: nuclear body, nucleolus, nucleoplasm, nucleus
Pathways: Gene expression (Transcription), RNA Polymerase II Transcription, RNA Polymerase III Transcription, RNA Polymerase III Transcription Initiation, RNA Polymerase III Transcription Initiation From Type 3 Promoter, RNA polymerase II transcribes snRNA genes
UniProt: Q8R2K7
Entrez ID: 330959
|
Does Knockout of Pigg in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Pigg
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Pigg (phosphatidylinositol glycan anchor biosynthesis, class G)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: GPI anchor biosynthetic process; MF: CP2 mannose-ethanolamine phosphotransferase activity, mannose-ethanolamine phosphotransferase activity, transferase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis - Mus musculus (mouse), Metabolism of proteins, Post-translational modification: synthesis of GPI-anchored proteins, Post-translational protein modification, Synthesis of glycosylphosphatidylinositol (GPI)
UniProt: D3Z3Y1, D3Z4I0, D3YTQ6
Entrez ID: 433931
|
Does Knockout of Polr1e in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,265
|
Knockout
|
Polr1e
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Polr1e (polymerase (RNA) I polypeptide E)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA-templated transcription, RNA polymerase I preinitiation complex assembly, nucleolar large rRNA transcription by RNA polymerase I, transcription elongation by RNA polymerase I, transcription initiation at RNA polymerase I promoter; MF: DNA binding, RNA polymerase I general transcription initiation factor binding, protein binding; CC: DNA-directed RNA polymerase complex, RNA polymerase I complex, fibrillar center, nucleolus, nucleoplasm, nucleus
Pathways: B-WICH complex positively regulates rRNA expression, Epigenetic regulation of gene expression, Gene expression (Transcription), Positive epigenetic regulation of rRNA expression, RNA Polymerase I Promoter Clearance, RNA Polymerase I Promoter Escape, RNA Polymerase I Transcription, RNA Polymerase I Transcription Initiation, RNA Polymerase I Transcription Termination, RNA polymerase - Mus musculus (mouse)
UniProt: Q8K202
Entrez ID: 64424
|
Does Knockout of Tmem196 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 2,477
|
Knockout
|
Tmem196
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Tmem196 (transmembrane protein 196)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: D3YWQ9
Entrez ID: 217951
|
Does Knockout of Elp6 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Elp6
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Elp6 (elongator acetyltransferase complex subunit 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, autophagosome maturation, autophagy, cellular response to stress, homeostasis of number of retina cells, inflammasome-mediated signaling pathway, locomotory behavior, motor behavior, neuromuscular process, neuromuscular process controlling balance, neuron apoptotic process, photoreceptor cell differentiation, positive regulation of cell migration, protein folding, response to unfolded protein, retina development in camera-type eye, tRNA processing, tRNA wobble uridine modification, translation, ubiquitin recycling; CC: cytoplasm, cytosol, elongator holoenzyme complex, nucleus
Pathways:
UniProt: Q8BK75
Entrez ID: 72341
|
Does Knockout of Ptprt in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 165
|
Knockout
|
Ptprt
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Ptprt (protein tyrosine phosphatase receptor type T)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell surface receptor protein tyrosine kinase signaling pathway, cellular response to interleukin-6, homophilic cell adhesion via plasma membrane adhesion molecules, negative regulation of cell migration, negative regulation of receptor signaling pathway via STAT, neuron projection development, regulation of synapse organization, signal transduction; MF: STAT family protein binding, alpha-actinin binding, alpha-catenin binding, beta-catenin binding, cadherin binding, delta-catenin binding, gamma-catenin binding, hydrolase activity, phosphoprotein phosphatase activity, protein homodimerization activity, protein phosphatase binding, protein tyrosine phosphatase activity, thiolester hydrolase activity, transmembrane receptor protein tyrosine phosphatase activity; CC: cell surface, glutamatergic synapse, membrane, plasma membrane, postsynaptic density membrane
Pathways:
UniProt: Q99M80
Entrez ID: 19281
|
Does Knockout of Tmem154 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Tmem154
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Tmem154 (transmembrane protein 154)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, membrane
Pathways:
UniProt: Q8C4Q9
Entrez ID: 320782
|
Does Knockout of Bcap31 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 82
|
Knockout
|
Bcap31
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Bcap31 (B cell receptor associated protein 31)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, endoplasmic reticulum to Golgi vesicle-mediated transport, intracellular protein transport, positive regulation of ERAD pathway, positive regulation of intrinsic apoptotic signaling pathway, positive regulation of retrograde protein transport, ER to cytosol, positive regulation of ubiquitin-dependent protein catabolic process, protein localization to endoplasmic reticulum exit site, protein targeting to mitochondrion, protein transport, response to endoplasmic reticulum stress, spermatogenesis, vesicle-mediated transport; MF: MHC class I protein binding, protein binding, protein-containing complex binding; CC: Golgi cisterna membrane, Golgi membrane, clathrin-coated vesicle, endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum-Golgi intermediate compartment membrane, lipid droplet, membrane, mitochondria-associated endoplasmic reticulum membrane contact site, perinuclear endoplasmic reticulum, plasma membrane
Pathways: Adaptive Immune System, Antigen Presentation: Folding, assembly and peptide loading of class I MHC, Apoptosis, Apoptotic cleavage of cellular proteins, Apoptotic execution phase, Class I MHC mediated antigen processing & presentation, Human papillomavirus infection - Mus musculus (mouse), Immune System, Programmed Cell Death, Protein processing in endoplasmic reticulum - Mus musculus (mouse), RHO GTPase cycle, RHOA GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q61335
Entrez ID: 27061
|
Does Knockout of Morn5 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Morn5
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Morn5 (MORN repeat containing 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cell projection, cellular_component, cilium, motile cilium, sperm flagellum
Pathways:
UniProt: Q9DAI9
Entrez ID: 75495
|
Does Knockout of 9230112D13Rik in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
9230112D13Rik
|
cell proliferation
|
Melanoma Cell Line
|
Gene: 9230112D13Rik (RIKEN cDNA 9230112D13 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q9D260
Entrez ID: 78243
|
Does Knockout of Gm10220 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Gm10220
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Gm10220 (predicted gene 10220)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: K7N660
Entrez ID: 434689
|
Does Knockout of Micu2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,271
|
Knockout
|
Micu2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Micu2 (mitochondrial calcium uptake 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: calcium import into the mitochondrion, cellular response to calcium ion, mitochondrial calcium ion homeostasis, mitochondrial calcium ion transmembrane transport, negative regulation of mitochondrial calcium ion concentration, positive regulation of mitochondrial calcium ion concentration; MF: calcium channel regulator activity, calcium ion binding, calcium ion sensor activity, metal ion binding, protein binding, protein heterodimerization activity; CC: calcium channel complex, membrane, mitochondrial inner membrane, mitochondrial intermembrane space, mitochondrion, uniplex complex
Pathways: Mitochondrial calcium ion transport, Processing of SMDT1, Transport of small molecules
UniProt: Q8CD10
Entrez ID: 68514
|
Does Knockout of Gpd2 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Gpd2
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Gpd2 (glycerol phosphate dehydrogenase 2, mitochondrial)
Type: protein-coding
Summary: Enables glycerol-3-phosphate dehydrogenase (quinone) activity. Involved in glycerol-3-phosphate shuttle. Acts upstream of or within camera-type eye development; gluconeogenesis; and glycerol-3-phosphate metabolic process. Located in mitochondrion. Is active in mitochondrial inner membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Used to study citrullinemia. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human GPD2 (glycerol-3-phosphate dehydrogenase 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: camera-type eye development, gluconeogenesis, glycerol catabolic process, glycerol-3-phosphate metabolic process, glycerol-3-phosphate shuttle, multicellular organism growth; MF: calcium ion binding, glycerol-3-phosphate dehydrogenase (quinone) activity, glycerol-3-phosphate dehydrogenase [NAD(P)+] activity, metal ion binding, oxidoreductase activity; CC: membrane, mitochondrial inner membrane, mitochondrion
Pathways: Glycerophospholipid biosynthesis, Glycerophospholipid metabolism - Mus musculus (mouse), Metabolism, Metabolism of lipids, Phospholipid metabolism, Synthesis of PA, Triglyceride catabolism, Triglyceride metabolism, aerobic respiration -- electron donors reaction list, glycerol degradation IV, glycerol-3-phosphate shuttle
UniProt: Q64521
Entrez ID: 14571
|
Does Knockout of Fkbp4 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
Fkbp4
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Fkbp4 (FK506 binding protein 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: androgen receptor signaling pathway, copper ion transport, embryo implantation, male sex differentiation, negative regulation of microtubule polymerization, negative regulation of microtubule polymerization or depolymerization, negative regulation of neuron projection development, prostate gland development, protein folding, protein-containing complex localization, reproductive structure development, steroid hormone receptor complex assembly; MF: ATP binding, GTP binding, copper-dependent protein binding, heat shock protein binding, isomerase activity, nuclear glucocorticoid receptor binding, peptidyl-prolyl cis-trans isomerase activity, phosphoprotein binding, protein binding, tau protein binding; CC: axonal growth cone, cytoplasm, cytoskeleton, cytosol, microtubule, mitochondrion, neuronal cell body, nucleoplasm, nucleus, perinuclear region of cytoplasm, protein-containing complex
Pathways: Attenuation phase, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, ESR-mediated signaling, Estrogen signaling pathway - Mus musculus (mouse), Estrogen-dependent gene expression, HSF1-dependent transactivation, HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand, Signal Transduction, Signaling by Nuclear Receptors
UniProt: P30416
Entrez ID: 14228
|
Does Knockout of Taf5l in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Taf5l
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Taf5l (TATA-box binding protein associated factor 5 like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of DNA-templated transcription, regulation of DNA repair, regulation of DNA-templated transcription, regulation of RNA splicing, regulation of somatic stem cell population maintenance, regulation of transcription by RNA polymerase II; MF: transcription coactivator activity; CC: SAGA complex, cytoplasmic ribonucleoprotein granule, nuclear speck, nucleus, transcription factor TFTC complex
Pathways: Basal transcription factors - Mus musculus (mouse)
UniProt: Q91WQ5
Entrez ID: 102162
|
Does Knockout of Wfdc8 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Wfdc8
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Wfdc8 (WAP four-disulfide core domain 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: molecular_function, peptidase inhibitor activity, serine-type endopeptidase inhibitor activity; CC: cellular_component, extracellular region, membrane
Pathways:
UniProt: Q4KUS1
Entrez ID: 277343
|
Does Knockout of Pabpc2 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Pabpc2
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Pabpc2 (poly(A) binding protein, cytoplasmic 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, regulation of mRNA 3'-end processing; MF: RNA binding, mRNA 3'-UTR binding, nucleic acid binding, poly(A) binding, poly(U) RNA binding; CC: cytoplasm, cytoplasmic stress granule, cytosol, lamellipodium, nucleus, ribonucleoprotein complex, spliceosomal complex
Pathways: RNA degradation - Mus musculus (mouse), mRNA surveillance pathway - Mus musculus (mouse)
UniProt: Q62029
Entrez ID: 18459
|
Does Knockout of Gzmb in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 161
|
Knockout
|
Gzmb
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Gzmb (granzyme B)
Type: protein-coding
Summary: This gene encodes a member of the granzyme subfamily of proteins, part of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) and proteolytically processed to generate the active protease, which induces target cell apoptosis. This protein also processes cytokines and degrades extracellular matrix proteins, and these roles are implicated in chronic inflammation and wound healing. Mice lacking a functional copy of this gene exhibit impaired immune cell-mediated cytolysis. [provided by RefSeq, Sep 2016].
Gene Ontology: BP: T cell mediated cytotoxicity, apoptotic process, ceramide biosynthetic process, defense response to bacterium, granzyme-mediated programmed cell death signaling pathway, killing of cells of another organism, natural killer cell mediated cytotoxicity, negative regulation of translation, plasma membrane repair, positive regulation of immune response to tumor cell, protein maturation, protein secretion, proteolysis, proteolysis involved in protein catabolic process, pyroptotic cell death, pyroptotic inflammatory response; MF: hydrolase activity, peptidase activity, protein binding, serine-type endopeptidase activity, serine-type peptidase activity; CC: cytolytic granule, cytoplasm, cytosol, early endosome, extracellular region, extracellular space, lysosome, membrane
Pathways: Allograft rejection - Mus musculus (mouse), Apoptosis - Mus musculus (mouse), Autoimmune thyroid disease - Mus musculus (mouse), Graft-versus-host disease - Mus musculus (mouse), Natural killer cell mediated cytotoxicity - Mus musculus (mouse), Transcriptional misregulation in cancer - Mus musculus (mouse), Type I diabetes mellitus - Mus musculus (mouse)
UniProt: P04187
Entrez ID: 14939
|
Does Knockout of Sox9 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Sox9
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Sox9 (SRY (sex determining region Y)-box 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ERK1 and ERK2 cascade, Harderian gland development, Notch signaling pathway, Sertoli cell development, Sertoli cell differentiation, anterior head development, aortic valve morphogenesis, astrocyte fate commitment, branching involved in ureteric bud morphogenesis, bronchus cartilage development, cartilage condensation, cartilage development, cell differentiation, cell fate commitment, cell-cell adhesion, cellular response to BMP stimulus, cellular response to epidermal growth factor stimulus, cellular response to heparin, cellular response to interleukin-1, cellular response to mechanical stimulus, cellular response to retinoic acid, cellular response to transforming growth factor beta stimulus, central nervous system development, chondrocyte development, chondrocyte differentiation, chondrocyte differentiation involved in endochondral bone morphogenesis, chondrocyte hypertrophy, chromatin remodeling, cochlea morphogenesis, cytoskeleton organization, endocardial cushion morphogenesis, endochondral bone morphogenesis, endocrine pancreas development, epidermal growth factor receptor signaling pathway, epithelial cell proliferation involved in prostatic bud elongation, epithelial to mesenchymal transition, epithelial tube branching involved in lung morphogenesis, extracellular matrix organization, gene expression, glandular epithelial cell differentiation, glial cell fate specification, growth plate cartilage chondrocyte growth, hair follicle development, heart development, heart valve development, heart valve formation, heart valve morphogenesis, homeostasis of number of cells within a tissue, intestinal epithelial cell differentiation, intestinal epithelial structure maintenance, intrahepatic bile duct development, lacrimal gland development, limb bud formation, lung epithelial cell differentiation, lung smooth muscle development, male germ-line sex determination, male gonad development, male sex determination, mammary gland development, metanephric nephron tubule formation, metanephric tubule development, morphogenesis of a branching epithelium, morphogenesis of an epithelium, negative regulation of DNA-templated transcription, negative regulation of apoptotic process, negative regulation of beta-catenin-TCF complex assembly, negative regulation of biomineral tissue development, negative regulation of bone mineralization, negative regulation of canonical Wnt signaling pathway, negative regulation of chondrocyte differentiation, negative regulation of epithelial cell differentiation, negative regulation of epithelial cell proliferation, negative regulation of fatty acid oxidation, negative regulation of gene expression, negative regulation of immune system process, negative regulation of mesenchymal cell apoptotic process, negative regulation of miRNA transcription, negative regulation of myoblast differentiation, negative regulation of ossification, negative regulation of osteoblast differentiation, negative regulation of photoreceptor cell differentiation, negative regulation of transcription by RNA polymerase II, neural crest cell development, neural crest cell fate specification, neuron fate specification, notochord development, nucleosome assembly, oligodendrocyte differentiation, ossification, otic vesicle development, otic vesicle formation, positive regulation of DNA-templated transcription, positive regulation of branching involved in ureteric bud morphogenesis, positive regulation of cartilage development, positive regulation of cell population proliferation, positive regulation of cell proliferation involved in heart morphogenesis, positive regulation of chondrocyte differentiation, positive regulation of chondrocyte proliferation, positive regulation of epithelial cell differentiation, positive regulation of epithelial cell migration, positive regulation of epithelial cell proliferation, positive regulation of extracellular matrix assembly, positive regulation of gene expression, positive regulation of kidney development, positive regulation of male gonad development, positive regulation of mesenchymal cell proliferation, positive regulation of mesenchymal stem cell differentiation, positive regulation of protein catabolic process, positive regulation of stem cell proliferation, positive regulation of transcription by RNA polymerase II, prostate gland development, prostate gland morphogenesis, protein localization to nucleus, protein-containing complex assembly, regulation of DNA-templated transcription, regulation of branching involved in lung morphogenesis, regulation of cell adhesion, regulation of cell cycle process, regulation of cell differentiation, regulation of cell population proliferation, regulation of cell proliferation involved in tissue homeostasis, regulation of epithelial cell proliferation involved in lung morphogenesis, regulation of gene expression, regulation of transcription by RNA polymerase II, renal vesicle induction, response to fatty acid, retina development in camera-type eye, retinal rod cell differentiation, signal transduction, skeletal system development, somatic stem cell population maintenance, spermatogenesis, tissue homeostasis, trachea cartilage development, type I pneumocyte differentiation, ureter development, ureter morphogenesis, ureter smooth muscle cell differentiation, ureter urothelium development; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, bHLH transcription factor binding, beta-catenin binding, chromatin binding, cis-regulatory region sequence-specific DNA binding, pre-mRNA intronic binding, protein binding, protein kinase A catalytic subunit binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding; CC: nucleoplasm, nucleus, protein-containing complex, transcription regulator complex
Pathways: Deactivation of the beta-catenin transactivating complex, Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription, Signal Transduction, Signaling by WNT, TCF dependent signaling in response to WNT, Transcriptional regulation by RUNX2, cAMP signaling pathway - Mus musculus (mouse)
UniProt: Q04887
Entrez ID: 20682
|
Does Knockout of Mad2l2 in Acute Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 684
|
Knockout
|
Mad2l2
|
cell proliferation
|
Acute Myeloid Leukemia Cell Line
|
Gene: Mad2l2 (MAD2 mitotic arrest deficient-like 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA damage response, signal transduction resulting in transcription, DNA repair, actin filament organization, cell division, double-strand break repair, error-prone translesion synthesis, negative regulation of canonical Wnt signaling pathway, negative regulation of cell-cell adhesion mediated by cadherin, negative regulation of double-strand break repair via homologous recombination, negative regulation of epithelial to mesenchymal transition, negative regulation of protein catabolic process, negative regulation of transcription by RNA polymerase II, negative regulation of transcription by competitive promoter binding, negative regulation of ubiquitin protein ligase activity, positive regulation of DNA-templated transcription, positive regulation of double-strand break repair via nonhomologous end joining, positive regulation of epithelial to mesenchymal transition, positive regulation of extracellular matrix assembly, positive regulation of gene expression, positive regulation of isotype switching, positive regulation of peptidyl-serine phosphorylation, regulation of cell growth, regulation of epithelial to mesenchymal transition, somatic diversification of immunoglobulins involved in immune response, telomere maintenance in response to DNA damage; MF: JUN kinase binding, RNA polymerase II-specific DNA-binding transcription factor binding, transcription corepressor activity; CC: anaphase-promoting complex, chromatin, chromosome, cytoplasm, cytoskeleton, nucleoplasm, nucleus, site of double-strand break, spindle, zeta DNA polymerase complex
Pathways: Bacterial invasion of epithelial cells - Mus musculus (mouse), Cell cycle - Mus musculus (mouse), DNA Damage Bypass, DNA Repair, Oocyte meiosis - Mus musculus (mouse), Progesterone-mediated oocyte maturation - Mus musculus (mouse), Translesion synthesis by POLI, Translesion synthesis by POLK, Translesion synthesis by REV1, Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
UniProt: Q9D752
Entrez ID: 71890
|
Does Knockout of Rnd2 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,158
|
Knockout
|
Rnd2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Rnd2 (Rho family GTPase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin filament organization, positive regulation of collateral sprouting, regulation of actin cytoskeleton organization, signal transduction, small GTPase-mediated signal transduction; MF: GTP binding, GTPase activity, nucleotide binding, protein binding, protein kinase binding; CC: acrosomal membrane, cytoplasmic vesicle, cytosol, early endosome, membrane, plasma membrane
Pathways: RHO GTPase cycle, RND2 GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q9QYM5
Entrez ID: 11858
|
Does Knockout of Rarb in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Rarb
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Rarb (retinoic acid receptor, beta)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: bone development, camera-type eye development, cell differentiation, embryonic digestive tract development, embryonic eye morphogenesis, embryonic hindlimb morphogenesis, embryonic morphogenesis, embryonic organ development, glandular epithelial cell development, growth plate cartilage development, limb development, multicellular organism growth, negative regulation of apoptotic process, negative regulation of cartilage development, negative regulation of cell differentiation, negative regulation of chondrocyte differentiation, negative regulation of stem cell proliferation, negative regulation of transcription by RNA polymerase II, neural precursor cell proliferation, neurogenesis, outflow tract morphogenesis, outflow tract septum morphogenesis, positive regulation of apoptotic process, positive regulation of cell population proliferation, positive regulation of programmed cell death, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of myelination, retina development in camera-type eye, retina layer formation, retinal pigment epithelium development, retinoic acid receptor signaling pathway, striatum development, ureteric bud development, ventricular cardiac muscle cell differentiation; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, heterocyclic compound binding, metal ion binding, nuclear receptor activity, nuclear retinoid X receptor binding, protein binding, protein-containing complex binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, zinc ion binding; CC: RNA polymerase II transcription regulator complex, cytoplasm, nucleoplasm, nucleus
Pathways: Gastric cancer - Mus musculus (mouse), Gene expression (Transcription), Generic Transcription Pathway, Non-small cell lung cancer - Mus musculus (mouse), Nuclear Receptor transcription pathway, Pathways in cancer - Mus musculus (mouse), RNA Polymerase II Transcription, Signal Transduction, Signaling by Nuclear Receptors, Signaling by Retinoic Acid, Small cell lung cancer - Mus musculus (mouse)
UniProt: P22605
Entrez ID: 218772
|
Does Knockout of Nup214 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Nup214
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Nup214 (nucleoporin 214)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA export from nucleus, intracellular protein transport, mRNA export from nucleus, mRNA transport, nucleocytoplasmic transport, protein export from nucleus, protein import into nucleus, protein transport, regulation of cell cycle, regulation of nucleocytoplasmic transport; MF: nuclear export signal receptor activity, nuclear localization sequence binding, structural constituent of nuclear pore; CC: cytoplasmic side of nuclear pore, nuclear envelope, nuclear pore, nucleus
Pathways: Amyotrophic lateral sclerosis - Mus musculus (mouse), Cell Cycle, Cell Cycle, Mitotic, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Gene Silencing by RNA, Gene expression (Transcription), Glucose metabolism, Glycolysis, HuR (ELAVL1) binds and stabilizes mRNA, IP3 and IP4 transport between cytosol and nucleus, IP6 and IP7 transport between cytosol and nucleus, IPs transport between nucleus and cytosol, Inositol phosphate metabolism, M Phase, Metabolism, Metabolism of RNA, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of non-coding RNA, Metabolism of proteins, Mitotic Prophase, Nuclear Envelope Breakdown, Nuclear Pore Complex (NPC) Disassembly, Nucleocytoplasmic transport - Mus musculus (mouse), Post-translational protein modification, Processing of Capped Intron-Containing Pre-mRNA, Regulation of Glucokinase by Glucokinase Regulatory Protein, Regulation of HSF1-mediated heat shock response, Regulation of mRNA stability by proteins that bind AU-rich elements, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, SUMOylation of DNA replication proteins, SUMOylation of RNA binding proteins, SUMOylation of SUMOylation proteins, SUMOylation of chromatin organization proteins, SUMOylation of ubiquitinylation proteins, Transcriptional regulation by small RNAs, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNA derived from an Intron-Containing Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, Transport of the SLBP Dependant Mature mRNA, Transport of the SLBP independent Mature mRNA, snRNP Assembly
UniProt: Q80U93
Entrez ID: 227720
|
Does Knockout of Usp37 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Usp37
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Usp37 (ubiquitin specific peptidase 37)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G1/S transition of mitotic cell cycle, cell division, protein K11-linked deubiquitination, protein K48-linked deubiquitination, protein deubiquitination, proteolysis, regulation of DNA replication, regulation of protein stability; MF: cysteine-type deubiquitinase activity, cysteine-type endopeptidase activity, cysteine-type peptidase activity, hydrolase activity, peptidase activity, protein kinase binding; CC: chromosome, cytosol, nucleus
Pathways: Deubiquitination, Metabolism of proteins, Post-translational protein modification, Ub-specific processing proteases
UniProt: Q8C0R0
Entrez ID: 319651
|
Does Knockout of Gsta3 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Gsta3
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Gsta3 (glutathione S-transferase, alpha 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: aflatoxin catabolic process, glutathione metabolic process, lipid metabolic process, ureteric bud development, xenobiotic metabolic process; MF: dinitrosyl-iron complex binding, fatty acid binding, glutathione binding, glutathione peroxidase activity, glutathione transferase activity, steroid Delta-isomerase activity, transferase activity; CC: cytoplasm, cytosol, mitochondrion
Pathways: Azathioprine ADME, Biological oxidations, Chemical carcinogenesis - DNA adducts - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Drug ADME, Drug metabolism - cytochrome P450 - Mus musculus (mouse), Drug metabolism - other enzymes - Mus musculus (mouse), Fluid shear stress and atherosclerosis - Mus musculus (mouse), Glutathione conjugation, Glutathione metabolism - Mus musculus (mouse), Heme degradation, Hepatocellular carcinoma - Mus musculus (mouse), Metabolism, Metabolism of porphyrins, Metabolism of xenobiotics by cytochrome P450 - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Phase II - Conjugation of compounds, glutathione-mediated detoxification
UniProt: P30115
Entrez ID: 14859
|
Does Knockout of Mbd4 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Mbd4
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Mbd4 (methyl-CpG binding domain protein 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, intrinsic apoptotic signaling pathway in response to DNA damage, mitotic G2 DNA damage checkpoint signaling, response to radiation; MF: DNA binding, catalytic activity, hydrolase activity, pyrimidine-specific mismatch base pair DNA N-glycosylase activity; CC: chromatin, cytoplasm, nuclear speck, nucleus
Pathways: Base Excision Repair, Base excision repair - Mus musculus (mouse), Base-Excision Repair, AP Site Formation, Cleavage of the damaged pyrimidine , DNA Repair, Depyrimidination, Displacement of DNA glycosylase by APEX1, Resolution of Abasic Sites (AP sites)
UniProt: Q9Z2D7
Entrez ID: 17193
|
Does Knockout of Adgrb2 in Microglial Cell Line causally result in response to virus?
| 0
| 2,429
|
Knockout
|
Adgrb2
|
response to virus
|
Microglial Cell Line
|
Gene: Adgrb2 (adhesion G protein-coupled receptor B2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, calcineurin-NFAT signaling cascade, cell surface receptor signaling pathway, negative regulation of angiogenesis, peripheral nervous system development, positive regulation of synapse assembly, signal transduction; MF: G protein-coupled receptor activity, protein binding, transmembrane signaling receptor activity; CC: extracellular region, glutamatergic synapse, membrane, plasma membrane, synapse
Pathways:
UniProt: Q8CGM1
Entrez ID: 230775
|
Does Knockout of Zfp663 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Zfp663
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Zfp663 (zinc finger protein 663)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of macromolecule metabolic process, regulation of primary metabolic process, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: nucleus
Pathways: Herpes simplex virus 1 infection - Mus musculus (mouse)
UniProt: A2A4U4, Q6NXM6
Entrez ID: 381405
|
Does Knockout of Sco1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Sco1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Sco1 (SCO1 cytochrome c oxidase assembly protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: copper ion homeostasis, cyclooxygenase pathway, gene expression, homeostasis of number of cells, immune response, intracellular copper ion homeostasis, intracellular iron ion homeostasis, intracellular zinc ion homeostasis, leukocyte differentiation, lipid catabolic process, liver development, mitochondrial cytochrome c oxidase assembly, mitochondrion organization, multicellular organism growth, negative regulation of cellular response to insulin stimulus, negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, negative regulation of proteasomal protein catabolic process, positive regulation of CAMKK-AMPK signaling cascade, post-transcriptional regulation of gene expression, protein localization to plasma membrane, protein secretion, respiratory chain complex IV assembly, spleen development, thymus development; MF: metal ion binding, molecular_function, protein binding; CC: membrane, mitochondrial inner membrane, mitochondrion, myofibril
Pathways: Aerobic respiration and respiratory electron transport, Complex IV assembly, Metabolism, Respiratory electron transport
UniProt: Q5SUC9
Entrez ID: 52892
|
Does Knockout of Vmn2r90 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Vmn2r90
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Vmn2r90 (vomeronasal 2, receptor 90)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, signal transduction; MF: G protein-coupled receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: A0A338P6K0, E9PXJ8, A0A338P772, A0A338P698
Entrez ID: 626942
|
Does Knockout of Gprin1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Gprin1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Gprin1 (G protein-regulated inducer of neurite outgrowth 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: neuron projection development; CC: cell projection, growth cone, membrane, plasma membrane
Pathways:
UniProt: Q3UNH4
Entrez ID: 26913
|
Does Knockout of Fdps in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 2,307
|
Knockout
|
Fdps
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Fdps (farnesyl diphosphate synthetase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cholesterol biosynthetic process, cholesterol biosynthetic process via desmosterol, cholesterol biosynthetic process via lathosterol, cholesterol metabolic process, farnesyl diphosphate biosynthetic process, geranyl diphosphate biosynthetic process, isoprenoid biosynthetic process, lipid metabolic process, positive regulation of cell growth involved in cardiac muscle cell development, positive regulation of cholesterol biosynthetic process, steroid biosynthetic process, steroid metabolic process, sterol biosynthetic process, zymosterol biosynthetic process; MF: (2E,6E)-farnesyl diphosphate synthase activity, dimethylallyltranstransferase activity, metal ion binding, prenyltransferase activity, transferase activity, transferase activity, transferring alkyl or aryl (other than methyl) groups; CC: cytoplasm, cytosol, mitochondrial matrix, mitochondrion, nucleoplasm, peroxisome
Pathways: <i>trans, trans</i>-farnesyl diphosphate biosynthesis, Cholesterol biosynthesis, Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Influenza A - Mus musculus (mouse), Metabolism, Metabolism of lipids, Metabolism of steroids, Terpenoid backbone biosynthesis - Mus musculus (mouse), superpathway of cholesterol biosynthesis
UniProt: Q920E5
Entrez ID: 110196
|
Does Knockout of Kcnn4 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 83
|
Knockout
|
Kcnn4
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Kcnn4 (potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: calcium ion transport, cardiac muscle hypertrophy, cell volume homeostasis, establishment of localization in cell, hepatocyte apoptotic process, immune system process, macropinocytosis, monoatomic anion transport, monoatomic ion transmembrane transport, monoatomic ion transport, mononuclear cell migration, negative regulation of cardiac muscle hypertrophy, negative regulation of cell volume, negative regulation of hepatic stellate cell proliferation, phospholipid translocation, positive regulation of G0 to G1 transition, positive regulation of T cell receptor signaling pathway, positive regulation of microglial cell activation, positive regulation of p38MAPK cascade, positive regulation of protein secretion, positive regulation of smooth muscle cell proliferation, potassium ion export across plasma membrane, potassium ion transmembrane transport, potassium ion transport, protein homotetramerization, regulation of angiotensin levels in blood, regulation of calcium ion import across plasma membrane, regulation of monocyte chemotactic protein-1 production, regulation of protein secretion, regulation of renin secretion into blood stream, regulation of smooth muscle cell proliferation, regulation of tumor necrosis factor production, saliva secretion, stabilization of membrane potential, vascular associated smooth muscle cell migration; MF: calcium-activated potassium channel activity, calmodulin binding, intermediate conductance calcium-activated potassium channel activity, inward rectifier potassium channel activity, potassium channel activity, protein homodimerization activity, protein phosphatase binding, small conductance calcium-activated potassium channel activity; CC: apical plasma membrane, basolateral plasma membrane, cell projection, cytosol, membrane, neuron projection, neuronal cell body, plasma membrane, ruffle membrane, vesicle
Pathways: Ca2+ activated K+ channels, GnRH secretion - Mus musculus (mouse), Insulin secretion - Mus musculus (mouse), Neuronal System, Potassium Channels, Protein digestion and absorption - Mus musculus (mouse), Salivary secretion - Mus musculus (mouse)
UniProt: O89109
Entrez ID: 16534
|
Does Knockout of Cep72 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Cep72
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Cep72 (centrosomal protein 72)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: centriole replication, gamma-tubulin complex localization, regulation of protein localization to centrosome, spindle organization; CC: centriolar satellite, centrosome, ciliary basal body, cytoplasm, cytoskeleton, cytosol
Pathways: AURKA Activation by TPX2, Anchoring of the basal body to the plasma membrane, Cell Cycle, Cell Cycle, Mitotic, Centrosome maturation, Cilium Assembly, G2/M Transition, Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, Mitotic G2-G2/M phases, Mitotic Prometaphase, Organelle biogenesis and maintenance, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Regulation of PLK1 Activity at G2/M Transition
UniProt: Q9D3R3
Entrez ID: 74470
|
Does Knockout of Crhbp in Regulatory T cell causally result in cell proliferation?
| 0
| 2,127
|
Knockout
|
Crhbp
|
cell proliferation
|
Regulatory T cell
|
Gene: Crhbp (corticotropin releasing hormone binding protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: behavioral response to ethanol, cellular response to cAMP, cellular response to calcium ion, cellular response to cocaine, cellular response to estradiol stimulus, cellular response to estrogen stimulus, cellular response to gonadotropin-releasing hormone, cellular response to immobilization stress, cellular response to potassium ion, cellular response to tumor necrosis factor, cellular response to xenobiotic stimulus, female pregnancy, hormone metabolic process, hormone-mediated signaling pathway, inflammatory response, maternal aggressive behavior, negative regulation of corticotropin secretion, negative regulation of corticotropin-releasing hormone receptor activity, regulated exocytosis, regulation of NMDA receptor activity, regulation of cellular response to stress, regulation of corticotropin secretion, synaptic transmission, dopaminergic; MF: corticotropin-releasing hormone binding, peptide binding; CC: Golgi apparatus, axon terminus, dendrite, dense core granule, endoplasmic reticulum, extracellular region, extracellular space, microtubule, multivesicular body, nucleus, perikaryon, secondary lysosome, secretory granule, varicosity
Pathways: Class B/2 (Secretin family receptors), GPCR ligand binding, Signal Transduction, Signaling by GPCR
UniProt: Q60571
Entrez ID: 12919
|
Does Knockout of Timm23 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Timm23
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Timm23 (translocase of inner mitochondrial membrane 23)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein import into mitochondrial matrix, protein transport, type 2 mitophagy; MF: enzyme binding, protein transmembrane transporter activity, transmembrane transporter activity; CC: TIM23 mitochondrial import inner membrane translocase complex, membrane, migrasome, mitochondrial inner membrane, mitochondrial intermembrane space, mitochondrion
Pathways:
UniProt: A0A2I3BS49, Q9CXU4, E9Q3T4, E9PVF9
Entrez ID: 53600
|
Does Knockout of Fkbp9 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Fkbp9
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Fkbp9 (FK506 binding protein 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein folding; MF: calcium ion binding, isomerase activity, metal ion binding, peptidyl-prolyl cis-trans isomerase activity; CC: endoplasmic reticulum, endoplasmic reticulum lumen
Pathways:
UniProt: Q9Z247
Entrez ID: 27055
|
Does Knockout of Smad7 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Smad7
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Smad7 (SMAD family member 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: SMAD protein signal transduction, adherens junction assembly, anatomical structure morphogenesis, artery morphogenesis, beta-catenin destruction complex disassembly, cell differentiation, cellular response to leukemia inhibitory factor, intracellular signal transduction, negative regulation of BMP signaling pathway, negative regulation of SMAD protein signal transduction, negative regulation of T cell cytokine production, negative regulation of T-helper 17 cell differentiation, negative regulation of T-helper 17 type immune response, negative regulation of activin receptor signaling pathway, negative regulation of chondrocyte proliferation, negative regulation of ossification, negative regulation of transcription by RNA polymerase II, negative regulation of transcription by competitive promoter binding, negative regulation of transforming growth factor beta receptor signaling pathway, positive regulation of cell-cell adhesion mediated by cadherin, positive regulation of chondrocyte hypertrophy, protein stabilization, protein-containing complex disassembly, protein-containing complex localization, regulation of DNA-templated transcription, regulation of cardiac muscle contraction, regulation of epithelial to mesenchymal transition, regulation of transcription by RNA polymerase II, regulation of transforming growth factor beta receptor signaling pathway, regulation of ventricular cardiac muscle cell membrane depolarization, response to laminar fluid shear stress, transforming growth factor beta receptor signaling pathway, ureteric bud development, ventricular cardiac muscle tissue morphogenesis, ventricular septum morphogenesis; MF: I-SMAD binding, activin receptor binding, beta-catenin binding, collagen binding, metal ion binding, protein binding, transcription corepressor activity, transcription regulator inhibitor activity, type I transforming growth factor beta receptor binding, ubiquitin protein ligase binding, ubiquitin-like ligase-substrate adaptor activity; CC: adherens junction, centrosome, ciliary basal body, cytoplasm, cytosol, fibrillar center, heteromeric SMAD protein complex, nucleoplasm, nucleus, plasma membrane, protein-containing complex, transcription regulator complex
Pathways: Deubiquitination, Downregulation of TGF-beta receptor signaling, Gene expression (Transcription), Generic Transcription Pathway, Hippo signaling pathway - Mus musculus (mouse), Metabolism of proteins, Post-translational protein modification, RNA Polymerase II Transcription, SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription, Signal Transduction, Signaling by BMP, Signaling by TGF-beta Receptor Complex, Signaling by TGFB family members, TGF-beta receptor signaling activates SMADs, TGF-beta signaling pathway - Mus musculus (mouse), Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer, Ub-specific processing proteases
UniProt: O35253
Entrez ID: 17131
|
Does Knockout of Wfdc15a in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 82
|
Knockout
|
Wfdc15a
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Wfdc15a (WAP four-disulfide core domain 15A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: antibacterial humoral response, defense response to bacterium, innate immune response; MF: peptidase inhibitor activity, serine-type endopeptidase inhibitor activity; CC: extracellular region, extracellular space
Pathways:
UniProt: Q8BH89
Entrez ID: 68221
|
Does Knockout of Lmbr1l in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Lmbr1l
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Lmbr1l (limb region 1 like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell apoptotic process, T cell differentiation, T cell proliferation, Wnt signaling pathway, endocytosis, hematopoietic stem cell differentiation, negative regulation of canonical Wnt signaling pathway, receptor-mediated endocytosis, signal transduction; MF: protein binding, transmembrane signaling receptor activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, plasma membrane
Pathways:
UniProt: Q9D1E5
Entrez ID: 74775
|
Does Knockout of Tiprl in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Tiprl
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Tiprl (TIP41, TOR signalling pathway regulator-like (S. cerevisiae))
Type: protein-coding
Summary: Predicted to enable protein phosphatase activator activity. Predicted to be involved in DNA damage checkpoint signaling and TOR signaling. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut; and immune system. Orthologous to human TIPRL (TOR signaling pathway regulator). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: DNA damage checkpoint signaling, TOR signaling; MF: molecular_function, protein phosphatase activator activity, protein phosphatase inhibitor activity; CC: cytoplasm, cytosol
Pathways:
UniProt: Q8BH58
Entrez ID: 226591
|
Does Knockout of Atg9a in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,288
|
Knockout
|
Atg9a
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Atg9a (autophagy related 9A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagosome assembly, autophagy, bone morphogenesis, innate immune response, lipid transport, mitophagy, negative regulation of interferon-beta production, negative regulation of macrophage cytokine production, piecemeal microautophagy of the nucleus, plasma membrane phospholipid scrambling, programmed necrotic cell death, protein localization to Golgi apparatus, protein localization to phagophore assembly site, reticulophagy; MF: phospholipid scramblase activity; CC: Golgi apparatus, Golgi membrane, autophagosome, cytoplasm, cytoplasmic vesicle, endoplasmic reticulum, endoplasmic reticulum membrane, endosome, late endosome, late endosome membrane, membrane, mitochondrial membrane, mitochondrion, phagophore assembly site, phagophore assembly site membrane, recycling endosome, recycling endosome membrane, synaptic membrane, synaptic vesicle, trans-Golgi network
Pathways: Autophagy, Autophagy - animal - Mus musculus (mouse), Autophagy - other - Mus musculus (mouse), Macroautophagy, Mitophagy, Mitophagy - animal - Mus musculus (mouse), PINK1-PRKN Mediated Mitophagy, Selective autophagy
UniProt: Q68FE2
Entrez ID: 245860
|
Does Knockout of Havcr1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Havcr1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Havcr1 (hepatitis A virus cellular receptor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: phagocytosis, engulfment, positive regulation of mast cell activation, response to lipopolysaccharide, response to wounding, symbiont entry into host cell; MF: phosphatidylserine binding, protein binding, virus receptor activity; CC: apical plasma membrane, brush border, cell surface, extracellular space, membrane, motile cilium, phagocytic vesicle, plasma membrane
Pathways:
UniProt: Q5QNS5
Entrez ID: 171283
|
Does Knockout of Skint7 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Skint7
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Skint7 (selection and upkeep of intraepithelial T cells 7)
Type: protein-coding
Summary: Predicted to enable signaling receptor binding activity. Predicted to be involved in T cell receptor signaling pathway and regulation of cytokine production. Predicted to be located in membrane. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including genitourinary system; gut; integumental system; liver; and thymus. [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: T cell activation, T cell receptor signaling pathway, regulation of T cell activation, regulation of cytokine production, regulation of leukocyte cell-cell adhesion; CC: external side of plasma membrane, membrane
Pathways:
UniProt: A7XV04
Entrez ID: 328505
|
Does Knockout of Slc29a1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 83
|
Knockout
|
Slc29a1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Slc29a1 (solute carrier family 29 (nucleoside transporters), member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ADP catabolic process, AMP catabolic process, adenine transport, adenosine transport, cellular response to glucose stimulus, cellular response to hypoxia, cytidine transport, excitatory postsynaptic potential, guanine transmembrane transport, hypoxanthine transport, inosine transport, lactation, neurotransmitter transport, neurotransmitter uptake, nucleobase transport, nucleoside transmembrane transport, nucleoside transport, purine nucleobase transmembrane transport, purine nucleoside transmembrane transport, pyrimidine nucleobase transmembrane transport, pyrimidine-containing compound transmembrane transport, response to antibiotic, thymine transport, uracil transmembrane transport, uridine transmembrane transport; MF: adenine transmembrane transporter activity, cytidine transmembrane transporter activity, guanine transmembrane transporter activity, neurotransmitter transmembrane transporter activity, nucleoside transmembrane transporter activity, purine nucleoside transmembrane transporter activity, pyrimidine- and adenosine-specific:sodium symporter activity, uracil transmembrane transporter activity, uridine transmembrane transporter activity; CC: apical plasma membrane, basolateral plasma membrane, membrane, plasma membrane, postsynapse, presynapse
Pathways: Alcoholism - Mus musculus (mouse), Azathioprine ADME, Drug ADME, Ribavirin ADME, SLC-mediated transmembrane transport, Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane, Transport of small molecules, Transport of vitamins, nucleosides, and related molecules
UniProt: Q9JIM1
Entrez ID: 63959
|
Does Knockout of Kcng3 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Kcng3
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Kcng3 (potassium voltage-gated channel, subfamily G, member 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: action potential, monoatomic ion transmembrane transport, monoatomic ion transport, potassium ion transmembrane transport, potassium ion transport, protein homooligomerization, regulation of potassium ion transmembrane transport, regulation of potassium ion transport, transmembrane transport; MF: monoatomic ion channel activity, potassium channel activity, potassium channel regulator activity, voltage-gated potassium channel activity; CC: cytoplasm, endoplasmic reticulum, membrane, monoatomic ion channel complex, plasma membrane, voltage-gated potassium channel complex
Pathways: Neuronal System, Potassium Channels, Voltage gated Potassium channels
UniProt: P59053
Entrez ID: 225030
|
Does Knockout of Etnk1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,290
|
Knockout
|
Etnk1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Etnk1 (ethanolamine kinase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: glycerophospholipid biosynthetic process, lipid metabolic process, phosphatidylethanolamine biosynthetic process, phospholipid biosynthetic process; MF: ATP binding, ethanolamine kinase activity, kinase activity, nucleotide binding, transferase activity; CC: cytoplasm
Pathways: Glycerophospholipid biosynthesis, Glycerophospholipid metabolism - Mus musculus (mouse), Metabolism, Metabolism of lipids, Phospholipid metabolism, Synthesis of PE, phosphatidylethanolamine biosynthesis II
UniProt: Q9D4V0
Entrez ID: 75320
|
Does Knockout of Vti1b in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Vti1b
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Vti1b (vesicle transport through interaction with t-SNAREs 1B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi to vacuole transport, intra-Golgi vesicle-mediated transport, intracellular protein transport, macroautophagy, protein transport, regulation of protein localization to plasma membrane, retrograde transport, endosome to Golgi, vesicle fusion with Golgi apparatus, vesicle-mediated transport; MF: SNAP receptor activity, SNARE binding, chloride channel inhibitor activity, protein binding; CC: ER to Golgi transport vesicle membrane, Golgi apparatus, SNARE complex, cytoplasm, cytosol, early endosome membrane, endomembrane system, endoplasmic reticulum membrane, endosome, late endosome membrane, lysosomal membrane, lysosome, membrane, neuronal cell body, perinuclear region of cytoplasm, presynaptic endosome membrane, recycling endosome, recycling endosome membrane, synaptic vesicle, vesicle
Pathways: SNARE interactions in vesicular transport - Mus musculus (mouse)
UniProt: F6T4B9, Q91XH6, E0CYE5, F6UHS3
Entrez ID: 53612
|
Does Knockout of Hsd17b2 in Embryonic Fibroblast Cell Line causally result in autophagy?
| 1
| 1,043
|
Knockout
|
Hsd17b2
|
autophagy
|
Embryonic Fibroblast Cell Line
|
Gene: Hsd17b2 (hydroxysteroid (17-beta) dehydrogenase 2)
Type: protein-coding
Summary: Predicted to enable estradiol 17-beta-dehydrogenase [NAD(P)+] activity and testosterone dehydrogenase (NAD+) activity. Acts upstream of or within in utero embryonic development and placenta development. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in several structures, including adrenal gland; genitourinary system; gut; labyrinthine zone; and liver. Orthologous to human HSD17B2 (hydroxysteroid 17-beta dehydrogenase 2). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: androgen biosynthetic process, androgen metabolic process, estrogen biosynthetic process, in utero embryonic development, lipid metabolic process, placenta development, response to retinoic acid, steroid biosynthetic process, steroid metabolic process; MF: estradiol 17-beta-dehydrogenase [NAD(P)+] activity, oxidoreductase activity, testosterone dehydrogenase (NAD+) activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, intracellular membrane-bounded organelle, membrane
Pathways: Estrogen biosynthesis, Metabolism, Metabolism of lipids, Metabolism of steroid hormones, Metabolism of steroids, Ovarian steroidogenesis - Mus musculus (mouse), Steroid hormone biosynthesis - Mus musculus (mouse), biosynthesis of estrogens
UniProt: P51658
Entrez ID: 15486
|
Does Knockout of Gfm1 in Acute Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 684
|
Knockout
|
Gfm1
|
cell proliferation
|
Acute Myeloid Leukemia Cell Line
|
Gene: Gfm1 (G elongation factor, mitochondrial 1)
Type: protein-coding
Summary: Predicted to enable GTPase activity and translation elongation factor activity. Predicted to be involved in mitochondrial translational elongation. Located in mitochondrion. Is expressed in embryo and extraembryonic component. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 1. Orthologous to human GFM1 (G elongation factor mitochondrial 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: mitochondrial translational elongation, translation, translational elongation; MF: GTP binding, GTPase activity, hydrolase activity, nucleotide binding, translation elongation factor activity; CC: mitochondrion
Pathways: Metabolism of proteins, Mitochondrial translation, Mitochondrial translation elongation, Translation
UniProt: Q8K0D5
Entrez ID: 28030
|
Does Knockout of Calm1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Calm1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Calm1 (calmodulin 1)
Type: protein-coding
Summary: This gene encodes a member of the EF-hand calcium-binding protein family. The encoded protein acts as a calcium sensor and is involved in relaying signals to calcium-sensitive proteins, enzymes and ion channels. The protein-calcium complex binds target proteins to regulate several cellular processes, including smooth muscle contraction, inflammation, apoptosis and the immune response. Mutations in the human gene are associated with catecholaminergic polymorphic ventricular tachycardia and long QT syndrome 14. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: G2/M transition of mitotic cell cycle, autophagosome membrane docking, calcineurin-mediated signaling, cell surface receptor signaling pathway via JAK-STAT, cellular response to interferon-beta, cellular response to type II interferon, detection of calcium ion, endocytosis, establishment of localization in cell, establishment of protein localization to membrane, establishment of protein localization to mitochondrial membrane, mitochondrion-endoplasmic reticulum membrane tethering, negative regulation of ryanodine-sensitive calcium-release channel activity, organelle localization by membrane tethering, positive regulation of receptor signaling pathway via JAK-STAT, presynaptic endocytosis, regulation of cardiac muscle cell action potential, regulation of cardiac muscle contraction, regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion, regulation of cell communication by electrical coupling involved in cardiac conduction, regulation of cytokinesis, regulation of heart rate, regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum, regulation of ryanodine-sensitive calcium-release channel activity, regulation of synaptic vesicle endocytosis, regulation of synaptic vesicle exocytosis, response to amphetamine, response to calcium ion, response to corticosterone; MF: adenylate cyclase activator activity, adenylate cyclase binding, calcium channel inhibitor activity, calcium channel regulator activity, calcium ion binding, calcium-dependent protein binding, metal ion binding, nitric-oxide synthase binding, nitric-oxide synthase regulator activity, phosphatidylinositol 3-kinase binding, protein binding, protein domain specific binding, protein kinase binding, protein phosphatase activator activity, protein serine/threonine kinase activator activity, titin binding, transmembrane transporter binding, type 3 metabotropic glutamate receptor binding; CC: Schaffer collateral - CA1 synapse, calcium channel complex, calyx of Held, catalytic complex, cell projection, centrosome, chromatin, cilium, cytoplasm, cytoskeleton, cytosol, distal axon, growth cone, mitochondrial membrane, mitochondrion, motile cilium, myelin sheath, nucleoplasm, nucleus, postsynaptic cytosol, presynaptic cytosol, protein-containing complex, sarcomere, sperm midpiece, spindle, spindle microtubule, spindle pole, synaptic vesicle membrane, voltage-gated potassium channel complex
Pathways: Activation of Ca-permeable Kainate Receptor, Activation of NMDA receptors and postsynaptic events, Activation of RAC1 downstream of NMDARs, Activation of kainate receptors upon glutamate binding, Adaptive Immune System, Adrenergic signaling in cardiomyocytes - Mus musculus (mouse), Alcoholism - Mus musculus (mouse), Aldosterone synthesis and secretion - Mus musculus (mouse), Alzheimer disease - Mus musculus (mouse), Amphetamine addiction - Mus musculus (mouse), Apelin signaling pathway - Mus musculus (mouse), Beta-catenin independent WNT signaling, C-type lectin receptor signaling pathway - Mus musculus (mouse), C-type lectin receptors (CLRs), CLEC7A (Dectin-1) induces NFAT activation, CLEC7A (Dectin-1) signaling, CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde, Ca-dependent events, Ca2+ pathway, CaM pathway, CaMK IV-mediated phosphorylation of CREB, Calcineurin activates NFAT, Calcium signaling pathway - Mus musculus (mouse), Calmodulin induced events, Cam-PDE 1 activation, Cardiac conduction, Cellular responses to mechanical stimuli, Cellular responses to stimuli, Cellular senescence - Mus musculus (mouse), Circadian entrainment - Mus musculus (mouse), DAG and IP3 signaling, Dopaminergic synapse - Mus musculus (mouse), Downstream signaling events of B Cell Receptor (BCR), ESR-mediated signaling, Estrogen signaling pathway - Mus musculus (mouse), Extra-nuclear estrogen signaling, FCERI mediated Ca+2 mobilization, Fc epsilon receptor (FCERI) signaling, Fluid shear stress and atherosclerosis - Mus musculus (mouse), G alpha (i) signalling events, G-protein mediated events, GPCR downstream signalling, Gastric acid secretion - Mus musculus (mouse), Glioma - Mus musculus (mouse), Glucagon signaling pathway - Mus musculus (mouse), Glycogen breakdown (glycogenolysis), Glycogen metabolism, GnRH signaling pathway - Mus musculus (mouse), Hemostasis, High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells, Human cytomegalovirus infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Immune System, Inactivation, recovery and regulation of the phototransduction cascade, Inflammatory mediator regulation of TRP channels - Mus musculus (mouse), Innate Immune System, Inositol phosphate metabolism, Insulin signaling pathway - Mus musculus (mouse), Intracellular signaling by second messengers, Ion channel transport, Ion homeostasis, Ion transport by P-type ATPases, Ionotropic activity of kainate receptors, Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), Long-term potentiation - Mus musculus (mouse), MAPK family signaling cascades, MAPK1/MAPK3 signaling, Melanogenesis - Mus musculus (mouse), Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of cofactors, Metabolism of nitric oxide: NOS3 activation and regulation, Metabolism of proteins, Metabolism of vitamins and cofactors, Metal ion SLC transporters, Muscle contraction, Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, Neurotrophin signaling pathway - Mus musculus (mouse), Olfactory transduction - Mus musculus (mouse), Oocyte meiosis - Mus musculus (mouse), Opioid Signalling, Oxytocin signaling pathway - Mus musculus (mouse), PKA activation, PKA-mediated phosphorylation of CREB, PLC beta mediated events, Parkinson disease - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Pertussis - Mus musculus (mouse), Phosphatidylinositol signaling system - Mus musculus (mouse), Phototransduction - Mus musculus (mouse), Platelet activation, signaling and aggregation, Platelet calcium homeostasis, Platelet degranulation , Platelet homeostasis, Post NMDA receptor activation events, Post-translational protein modification, Protein methylation, RAF activation, RAF/MAP kinase cascade, RAS processing, RHO GTPase Effectors, RHO GTPases activate IQGAPs, RHO GTPases activate PAKs, Rap1 signaling pathway - Mus musculus (mouse), Ras signaling pathway - Mus musculus (mouse), Reduction of cytosolic Ca++ levels, Renin secretion - Mus musculus (mouse), Response of endothelial cells to shear stress, Response to elevated platelet cytosolic Ca2+, SLC-mediated transmembrane transport, Salivary secretion - Mus musculus (mouse), Sensory Perception, Signal Transduction, Signaling by GPCR, Signaling by Nuclear Receptors, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by VEGF, Signaling by WNT, Signaling by the B Cell Receptor (BCR), Smooth Muscle Contraction, Sodium/Calcium exchangers, Stimuli-sensing channels, Synthesis of IP3 and IP4 in the cytosol, Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation, The phototransduction cascade, Transmission across Chemical Synapses, Transport of small molecules, Tuberculosis - Mus musculus (mouse), Unblocking of NMDA receptors, glutamate binding and activation, VEGFA-VEGFR2 Pathway, VEGFR2 mediated vascular permeability, Vascular smooth muscle contraction - Mus musculus (mouse), Visual phototransduction, cAMP signaling pathway - Mus musculus (mouse), cGMP-PKG signaling pathway - Mus musculus (mouse), eNOS activation
UniProt: P0DP26
Entrez ID: 12313
|
Does Knockout of Vps72 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Vps72
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Vps72 (vacuolar protein sorting 72)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, positive regulation of DNA-templated transcription, positive regulation of double-strand break repair via homologous recombination, regulation of DNA-templated transcription, regulation of apoptotic process, regulation of cell cycle, regulation of double-strand break repair, somatic stem cell population maintenance, transcription initiation-coupled chromatin remodeling; MF: DNA binding, histone binding, histone chaperone activity; CC: NuA4 histone acetyltransferase complex, nuclear speck, nucleosome, nucleus, protein-containing complex
Pathways:
UniProt: Q62481
Entrez ID: 21427
|
Does Knockout of Ppp2r2d in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Ppp2r2d
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Ppp2r2d (protein phosphatase 2, regulatory subunit B, delta)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, exit from mitosis, mitotic cell cycle, regulation of chromosome segregation; MF: enzyme-substrate adaptor activity, protein phosphatase regulator activity; CC: cytoplasm, cytosol, protein phosphatase type 2A complex
Pathways: AMPK signaling pathway - Mus musculus (mouse), Adrenergic signaling in cardiomyocytes - Mus musculus (mouse), Chagas disease - Mus musculus (mouse), Dopaminergic synapse - Mus musculus (mouse), Hepatitis C - Mus musculus (mouse), Hippo signaling pathway - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), Sphingolipid signaling pathway - Mus musculus (mouse), Tight junction - Mus musculus (mouse), mRNA surveillance pathway - Mus musculus (mouse)
UniProt: Q925E7
Entrez ID: 52432
|
Does Knockout of Sema6c in Regulatory T cell causally result in cell proliferation?
| 0
| 2,127
|
Knockout
|
Sema6c
|
cell proliferation
|
Regulatory T cell
|
Gene: Sema6c (sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: axon guidance, cell differentiation, negative chemotaxis, negative regulation of axon extension, nervous system development, neural crest cell migration, positive regulation of cell migration, semaphorin-plexin signaling pathway; MF: chemorepellent activity, semaphorin receptor binding; CC: cell surface, cytoplasm, membrane, plasma membrane
Pathways: Axon guidance - Mus musculus (mouse)
UniProt: Q9WTM3
Entrez ID: 20360
|
Does Knockout of Ctse in Embryonic Fibroblast Cell Line causally result in response to virus?
| 1
| 1,133
|
Knockout
|
Ctse
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Ctse (cathepsin E)
Type: protein-coding
Summary: This gene encodes a member of the peptidase A1 family of aspartate proteases and preproprotein that is proteolytically processed to generate a mature protein product. The encoded protein may be involved in antigen processing and the maturation of secretory proteins. Elevated expression of this gene has been observed in neurodegeneration. Homozygous knockout mice for this gene exhibit lysosomal storage disorder, impaired autophagy, mitochondrial abnormalities, dermatitis, and reduced weight gain in an obesity model. [provided by RefSeq, Aug 2015].
Gene Ontology: BP: antigen processing and presentation of exogenous peptide antigen via MHC class II, protein autoprocessing, proteolysis; MF: aspartic-type endopeptidase activity, hydrolase activity, identical protein binding, peptidase activity; CC: endosome
Pathways: Adaptive Immune System, Immune System, Lysosome - Mus musculus (mouse), MHC class II antigen presentation
UniProt: P70269
Entrez ID: 13034
|
Does Knockout of Hace1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Hace1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Hace1 (HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi organization, membrane fusion, protein K48-linked ubiquitination, protein ubiquitination, regulation of cell migration, ubiquitin-dependent protein catabolic process; MF: small GTPase binding, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity; CC: Golgi apparatus, Golgi cisterna membrane, Golgi membrane, cytoplasm, endoplasmic reticulum, membrane, nuclear body, nucleus
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System
UniProt: Q3U0D9
Entrez ID: 209462
|
Does Knockout of Csnk2a1 in Acute Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 684
|
Knockout
|
Csnk2a1
|
cell proliferation
|
Acute Myeloid Leukemia Cell Line
|
Gene: Csnk2a1 (casein kinase 2, alpha 1 polypeptide)
Type: protein-coding
Summary: Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. It is involved in various cellular processes, including cell cycle control, apoptosis, and circadian rhythms. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. [provided by RefSeq, Feb 2014].
Gene Ontology: BP: Wnt signaling pathway, apoptotic process, cerebral cortex development, double-strand break repair, liver regeneration, negative regulation of apoptotic signaling pathway, negative regulation of double-strand break repair via homologous recombination, positive regulation of Wnt signaling pathway, positive regulation of aggrephagy, positive regulation of cell growth, positive regulation of cell population proliferation, positive regulation of protein catabolic process, regulation of cell cycle, regulation of chromosome separation, regulation of protein localization to plasma membrane, response to testosterone, rhythmic process; MF: ATP binding, beta-catenin binding, identical protein binding, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein phosphatase regulator activity, protein serine kinase activity, protein serine/threonine kinase activity, ribonucleoprotein complex binding, transferase activity; CC: PML body, PcG protein complex, Sin3-type complex, chromatin, cytosol, nucleoplasm, nucleus, protein kinase CK2 complex
Pathways: Adaptive Immune System, Adherens junction - Mus musculus (mouse), Adherens junctions interactions, Alzheimer disease - Mus musculus (mouse), Autophagy, Axon guidance, Cell Cycle, Cell Cycle, Mitotic, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Chaperonin-mediated protein folding, Co-inhibition by PD-1, Condensation of Prometaphase Chromosomes, Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding, Developmental Biology, Gene expression (Transcription), Generic Transcription Pathway, Glycerophospholipid biosynthesis, Immune System, Intracellular signaling by second messengers, L1CAM interactions, M Phase, Macroautophagy, Measles - Mus musculus (mouse), Metabolism, Metabolism of lipids, Metabolism of proteins, Mitophagy, Mitophagy - animal - Mus musculus (mouse), Mitotic Prometaphase, NF-kappa B signaling pathway - Mus musculus (mouse), Nervous system development, PD-L1 expression and PD-1 checkpoint pathway in cancer - Mus musculus (mouse), PIP3 activates AKT signaling, PTEN Regulation, Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Phospholipid metabolism, Prion disease - Mus musculus (mouse), Protein folding, RNA Polymerase II Transcription, RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known, Receptor Mediated Mitophagy, Regulation of CDH1 Expression and Function, Regulation of CDH1 posttranslational processing and trafficking to plasma membrane, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of PTEN stability and activity, Regulation of T cell activation by CD28 family, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Ribosome biogenesis in eukaryotes - Mus musculus (mouse), SPOP-mediated proteasomal degradation of PD-L1(CD274), Selective autophagy, Signal Transduction, Signal transduction by L1, Signaling by WNT, Synthesis of PC, TCF dependent signaling in response to WNT, Transcriptional Regulation by TP53, Transcriptional regulation by RUNX1, WNT mediated activation of DVL, Wnt signaling pathway - Mus musculus (mouse)
UniProt: Q60737
Entrez ID: 12995
|
Does Knockout of Cdkn1b in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Cdkn1b
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Cdkn1b (cyclin dependent kinase inhibitor 1B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G1/S transition of mitotic cell cycle, Notch signaling pathway, autophagic cell death, cellular response to antibiotic, cellular response to lithium ion, heart development, inner ear development, negative regulation of DNA-templated transcription, negative regulation of cardiac muscle tissue regeneration, negative regulation of cell growth, negative regulation of cell population proliferation, negative regulation of epithelial cell apoptotic process, negative regulation of epithelial cell proliferation, negative regulation of epithelial cell proliferation involved in prostate gland development, negative regulation of growth, negative regulation of mitotic cell cycle, negative regulation of vascular associated smooth muscle cell proliferation, nuclear export, placenta development, positive regulation of cell population proliferation, positive regulation of microtubule polymerization, positive regulation of protein catabolic process, potassium ion transport, programmed cell death, regulation of G1/S transition of mitotic cell cycle, regulation of cell cycle, regulation of cell cycle G1/S phase transition, regulation of cell migration, regulation of exit from mitosis, regulation of lens fiber cell differentiation, regulation of mitotic cell cycle, regulation of mitotic cell cycle phase transition, sensory perception of sound; MF: Hsp70 protein binding, cyclin binding, cyclin-dependent protein kinase regulator activity, cyclin-dependent protein serine/threonine kinase inhibitor activity, molecular adaptor activity, molecular function inhibitor activity, protein binding, protein kinase binding, protein kinase inhibitor activity, protein phosphatase binding, protein-containing complex binding, protein-folding chaperone binding, ubiquitin ligase activator activity, ubiquitin protein ligase binding; CC: Cul4A-RING E3 ubiquitin ligase complex, centrosome, ciliary basal body, cilium, cytoplasm, cytosol, endosome, nucleoplasm, nucleus, protein-containing complex
Pathways: AGE-RAGE signaling pathway in diabetic complications - Mus musculus (mouse), AKT phosphorylates targets in the cytosol, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle - Mus musculus (mouse), Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, Chronic myeloid leukemia - Mus musculus (mouse), Cushing syndrome - Mus musculus (mouse), Cyclin A:Cdk2-associated events at S phase entry, Cyclin D associated events in G1, Cyclin E associated events during G1/S transition , Cytokine Signaling in Immune system, DNA Damage/Telomere Stress Induced Senescence, ESR-mediated signaling, Epstein-Barr virus infection - Mus musculus (mouse), ErbB signaling pathway - Mus musculus (mouse), Estrogen-dependent nuclear events downstream of ESR-membrane signaling, Extra-nuclear estrogen signaling, FLT3 Signaling, FoxO signaling pathway - Mus musculus (mouse), G1 Phase, G1/S DNA Damage Checkpoints, G1/S Transition, Gastric cancer - Mus musculus (mouse), Gene expression (Transcription), Generic Transcription Pathway, HIF-1 signaling pathway - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Immune System, Intracellular signaling by second messengers, Measles - Mus musculus (mouse), MicroRNAs in cancer - Mus musculus (mouse), Mitotic G1 phase and G1/S transition, PI3K-Akt signaling pathway - Mus musculus (mouse), PIP3 activates AKT signaling, PTK6 Regulates Cell Cycle, Pathways in cancer - Mus musculus (mouse), Prostate cancer - Mus musculus (mouse), RNA Polymerase II Transcription, S Phase, SCF(Skp2)-mediated degradation of p27/p21, Senescence-Associated Secretory Phenotype (SASP), Signal Transduction, Signaling by Non-Receptor Tyrosine Kinases, Signaling by Nuclear Receptors, Signaling by PTK6, Small cell lung cancer - Mus musculus (mouse), TP53 Regulates Transcription of Cell Cycle Genes, TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest, Transcriptional Regulation by TP53, Transcriptional misregulation in cancer - Mus musculus (mouse), Viral carcinogenesis - Mus musculus (mouse), p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint
UniProt: P46414
Entrez ID: 12576
|
Does Knockout of Ntn4 in Regulatory T cell causally result in cell proliferation?
| 0
| 2,127
|
Knockout
|
Ntn4
|
cell proliferation
|
Regulatory T cell
|
Gene: Ntn4 (netrin 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: animal organ morphogenesis, axon guidance, basement membrane assembly, cell migration, neuron remodeling, regulation of branching involved in salivary gland morphogenesis by extracellular matrix-epithelial cell signaling, substrate adhesion-dependent cell spreading, tissue development; MF: laminin-1 binding, protein binding; CC: basement membrane, extracellular region, laminin complex, plasma membrane
Pathways: Axon guidance, Axon guidance - Mus musculus (mouse), Developmental Biology, Nervous system development, Netrin-1 signaling
UniProt: Q9JI33
Entrez ID: 57764
|
Does Knockout of Efna3 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Efna3
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Efna3 (ephrin A3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: axon guidance, ephrin receptor signaling pathway, negative regulation of angiogenesis, positive regulation of amyloid precursor protein catabolic process, regulation of neuron differentiation; MF: ephrin receptor binding; CC: membrane, plasma membrane, side of membrane
Pathways: Axon guidance, Axon guidance - Mus musculus (mouse), Developmental Biology, EPH-Ephrin signaling, EPH-ephrin mediated repulsion of cells, EPHA-mediated growth cone collapse, MAPK signaling pathway - Mus musculus (mouse), MicroRNAs in cancer - Mus musculus (mouse), Nervous system development, PI3K-Akt signaling pathway - Mus musculus (mouse), Rap1 signaling pathway - Mus musculus (mouse), Ras signaling pathway - Mus musculus (mouse)
UniProt: O08545
Entrez ID: 13638
|
Does Knockout of B230219D22Rik in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
B230219D22Rik
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: B230219D22Rik (RIKEN cDNA B230219D22 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q80X32
Entrez ID: 78521
|
Does Knockout of Prl8a2 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Prl8a2
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Prl8a2 (prolactin family 8, subfamily a, member 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell surface receptor signaling pathway, female pregnancy, mammary gland development, maternal process involved in female pregnancy, positive regulation of lactation, positive regulation of receptor signaling pathway via JAK-STAT, response to hypoxia, response to nutrient levels; MF: hormone activity, prolactin receptor binding; CC: extracellular region, extracellular space
Pathways:
UniProt: O54832, O35258, A0A286YDW1
Entrez ID: 13529
|
Does Knockout of Plcd4 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Plcd4
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Plcd4 (phospholipase C, delta 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: acrosome reaction, intracellular signal transduction, lipid catabolic process, lipid metabolic process, phosphatidylinositol metabolic process, signal transduction, small GTPase-mediated signal transduction; MF: G-protein alpha-subunit binding, calcium ion binding, guanyl-nucleotide exchange factor activity, hydrolase activity, metal ion binding, phosphatidylinositol phospholipase C activity, phosphatidylinositol-4,5-bisphosphate phospholipase C activity, phospholipase C activity, phosphoric diester hydrolase activity; CC: cytoplasm, cytosol, endoplasmic reticulum, membrane, nucleus, plasma membrane
Pathways: AGE-RAGE signaling pathway in diabetic complications - Mus musculus (mouse), Calcium signaling pathway - Mus musculus (mouse), D-<i>myo</i>-inositol (1,4,5)-trisphosphate biosynthesis, D-<i>myo</i>-inositol-5-phosphate metabolism, Inositol phosphate metabolism, Inositol phosphate metabolism - Mus musculus (mouse), Metabolism, PIP metabolism, Phosphatidylinositol signaling system - Mus musculus (mouse), Synthesis of IP3 and IP4 in the cytosol, Thyroid hormone signaling pathway - Mus musculus (mouse), phospholipases
UniProt: Q8K3R3
Entrez ID: 18802
|
Does Knockout of Mrps11 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 579
|
Knockout
|
Mrps11
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Mrps11 (mitochondrial ribosomal protein S11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial translation, translation; MF: structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial small ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Ribosome - Mus musculus (mouse)
UniProt: A0A0U1RPK7, Q3U8Y1
Entrez ID: 67994
|
Does Knockout of Mfsd5 in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Mfsd5
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Mfsd5 (major facilitator superfamily domain containing 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, molybdate ion transport, monoatomic ion transport, response to food, response to starvation; MF: molecular_function, molybdate ion transmembrane transporter activity; CC: membrane, plasma membrane
Pathways:
UniProt: Q921Y4
Entrez ID: 106073
|
Does Knockout of Fadd in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
Fadd
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Fadd (Fas associated via death domain)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell differentiation, T cell differentiation in thymus, T cell homeostasis, TRAIL-activated apoptotic signaling pathway, apoptotic process, apoptotic signaling pathway, behavioral response to cocaine, cardiac muscle tissue development, cellular response to mechanical stimulus, death-inducing signaling complex assembly, defense response to other organism, defense response to virus, extrinsic apoptotic signaling pathway, extrinsic apoptotic signaling pathway in absence of ligand, extrinsic apoptotic signaling pathway via death domain receptors, immune system process, innate immune response, kidney development, lymph node development, motor neuron apoptotic process, necroptotic signaling pathway, negative regulation of activation-induced cell death of T cells, negative regulation of necroptotic process, positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation, positive regulation of T cell mediated cytotoxicity, positive regulation of activated T cell proliferation, positive regulation of adaptive immune response, positive regulation of apoptotic process, positive regulation of canonical NF-kappaB signal transduction, positive regulation of cytokine production, positive regulation of execution phase of apoptosis, positive regulation of extrinsic apoptotic signaling pathway, positive regulation of immune response, positive regulation of innate immune response, positive regulation of interleukin-8 production, positive regulation of macrophage differentiation, positive regulation of proteolysis, positive regulation of transcription by RNA polymerase II, positive regulation of tumor necrosis factor production, positive regulation of type I interferon-mediated signaling pathway, positive regulation of type II interferon production, regulation of apoptotic process, regulation of necroptotic process, response to cocaine, signal transduction, spleen development, thymus development; MF: caspase binding, death effector domain binding, death receptor binding, identical protein binding, protease binding, protein binding, protein-containing complex binding, protein-macromolecule adaptor activity, receptor serine/threonine kinase binding, signaling adaptor activity, tumor necrosis factor receptor binding, tumor necrosis factor receptor superfamily binding; CC: CD95 death-inducing signaling complex, cell body, cytoplasm, cytosol, death-inducing signaling complex, plasma membrane, protein-containing complex, ripoptosome
Pathways: Alcoholic liver disease - Mus musculus (mouse), Alzheimer disease - Mus musculus (mouse), Apoptosis, Apoptosis - Mus musculus (mouse), Apoptosis - multiple species - Mus musculus (mouse), CASP8 activity is inhibited, Caspase activation via Death Receptors in the presence of ligand, Caspase activation via extrinsic apoptotic signalling pathway, Chagas disease - Mus musculus (mouse), Death Receptor Signaling, Dimerization of procaspase-8, Epstein-Barr virus infection - Mus musculus (mouse), FasL/ CD95L signaling, Hepatitis B - Mus musculus (mouse), Hepatitis C - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), IL-17 signaling pathway - Mus musculus (mouse), Immune System, Influenza A - Mus musculus (mouse), Innate Immune System, Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Measles - Mus musculus (mouse), MyD88-independent TLR4 cascade , NOD-like receptor signaling pathway - Mus musculus (mouse), Necroptosis - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Programmed Cell Death, RIG-I-like receptor signaling pathway - Mus musculus (mouse), RIPK1-mediated regulated necrosis, Regulated Necrosis, Regulation by c-FLIP, Regulation of TNFR1 signaling, Regulation of necroptotic cell death, Salmonella infection - Mus musculus (mouse), Signal Transduction, TNF signaling, TNF signaling pathway - Mus musculus (mouse), TNFR1-induced proapoptotic signaling, TRAIL signaling, TRIF (TICAM1)-mediated TLR4 signaling , TRIF-mediated programmed cell death, Toll Like Receptor 4 (TLR4) Cascade, Toll-like Receptor Cascades, Toll-like receptor signaling pathway - Mus musculus (mouse), Tuberculosis - Mus musculus (mouse)
UniProt: Q61160
Entrez ID: 14082
|
Does Knockout of Hsd3b3 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Hsd3b3
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Hsd3b3 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: C21-steroid hormone biosynthetic process, C21-steroid hormone metabolic process, androgen biosynthetic process, negative regulation of iron ion transport, steroid biosynthetic process; MF: 3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity, catalytic activity, isomerase activity, oxidoreductase activity, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, steroid Delta-isomerase activity; CC: cilium, cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, intercellular bridge, intracellular membrane-bounded organelle, membrane, microtubule cytoskeleton, mitochondrial inner membrane, mitochondrial intermembrane space, mitochondrial membrane, mitochondrion, nucleolus
Pathways: Aldosterone synthesis and secretion - Mus musculus (mouse), Androgen biosynthesis, Cortisol synthesis and secretion - Mus musculus (mouse), Cushing syndrome - Mus musculus (mouse), Glucocorticoid biosynthesis, Metabolism, Metabolism of lipids, Metabolism of steroid hormones, Metabolism of steroids, Mineralocorticoid biosynthesis, Ovarian steroidogenesis - Mus musculus (mouse), Steroid hormone biosynthesis - Mus musculus (mouse), biosynthesis of androgens, biosynthesis of corticosteroids
UniProt: P26150
Entrez ID: 15494
|
Does Knockout of Cox5b in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Cox5b
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Cox5b (cytochrome c oxidase subunit 5B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial electron transport, cytochrome c to oxygen, oxidative phosphorylation; CC: membrane, mitochondrial envelope, mitochondrial inner membrane, mitochondrial membrane, mitochondrion, myelin sheath, respiratory chain complex IV
Pathways: Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Cardiac muscle contraction - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Diabetic cardiomyopathy - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Non-alcoholic fatty liver disease - Mus musculus (mouse), Oxidative phosphorylation - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Thermogenesis - Mus musculus (mouse), aerobic respiration -- electron donor II
UniProt: A0A0A6YVR0, Q9D881, F7C106
Entrez ID: 12859
|
Does Knockout of Elmo2 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Elmo2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Elmo2 (engulfment and cell motility 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin filament organization, apoptotic process, cell chemotaxis, cell motility, phagocytosis; MF: SH3 domain binding, receptor tyrosine kinase binding; CC: cytoplasm, cytosol, membrane
Pathways: Bacterial invasion of epithelial cells - Mus musculus (mouse), Fcgamma receptor (FCGR) dependent phagocytosis, Immune System, Innate Immune System, PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases, RHO GTPase cycle, RHOG GTPase cycle, Regulation of actin dynamics for phagocytic cup formation, Salmonella infection - Mus musculus (mouse), Signal Transduction, Signaling by Non-Receptor Tyrosine Kinases, Signaling by PTK6, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by VEGF, VEGFA-VEGFR2 Pathway, Yersinia infection - Mus musculus (mouse)
UniProt: Q8BHL5
Entrez ID: 140579
|
Does Knockout of Cdk11b in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Cdk11b
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Cdk11b (cyclin dependent kinase 11B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: blastocyst development, mitotic sister chromatid cohesion, centromeric, negative regulation of apoptotic signaling pathway, regulation of RNA splicing, regulation of apoptotic process, regulation of cell cycle, regulation of centrosome cycle, regulation of mitotic nuclear division; MF: ATP binding, cyclin-dependent protein serine/threonine kinase activity, kinase activity, nucleotide binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cyclin-dependent protein kinase holoenzyme complex, nucleoplasm, nucleus
Pathways: Cell Cycle, Cell Cycle, Mitotic, Centrosome maturation, G2/M Transition, Mitotic G2-G2/M phases, Recruitment of mitotic centrosome proteins and complexes
UniProt: P24788
Entrez ID: 12537
|
Does Knockout of Tbx21 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Tbx21
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Tbx21 (T-box 21)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell differentiation, T-helper 1 cell lineage commitment, cell fate specification, lymphocyte migration, negative regulation of DNA-templated transcription, negative regulation of T-helper 17 cell differentiation, negative regulation of T-helper 17 cell lineage commitment, negative regulation of T-helper 2 cell cytokine production, negative regulation of interleukin-2 production, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of T-helper 1 cell cytokine production, positive regulation of gene expression, positive regulation of isotype switching to IgG isotypes, positive regulation of transcription by RNA polymerase II, proteasome-mediated ubiquitin-dependent protein catabolic process, regulation of DNA-templated transcription, regulation of T cell differentiation, regulation of immune response, regulation of transcription by RNA polymerase II, response to virus; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding; CC: chromatin, neuronal cell body, nucleus
Pathways: Inflammatory bowel disease - Mus musculus (mouse), Th1 and Th2 cell differentiation - Mus musculus (mouse), Th17 cell differentiation - Mus musculus (mouse)
UniProt: Q9JKD8
Entrez ID: 57765
|
Does Knockout of Nup214 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 2,307
|
Knockout
|
Nup214
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Nup214 (nucleoporin 214)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA export from nucleus, intracellular protein transport, mRNA export from nucleus, mRNA transport, nucleocytoplasmic transport, protein export from nucleus, protein import into nucleus, protein transport, regulation of cell cycle, regulation of nucleocytoplasmic transport; MF: nuclear export signal receptor activity, nuclear localization sequence binding, structural constituent of nuclear pore; CC: cytoplasmic side of nuclear pore, nuclear envelope, nuclear pore, nucleus
Pathways: Amyotrophic lateral sclerosis - Mus musculus (mouse), Cell Cycle, Cell Cycle, Mitotic, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Gene Silencing by RNA, Gene expression (Transcription), Glucose metabolism, Glycolysis, HuR (ELAVL1) binds and stabilizes mRNA, IP3 and IP4 transport between cytosol and nucleus, IP6 and IP7 transport between cytosol and nucleus, IPs transport between nucleus and cytosol, Inositol phosphate metabolism, M Phase, Metabolism, Metabolism of RNA, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of non-coding RNA, Metabolism of proteins, Mitotic Prophase, Nuclear Envelope Breakdown, Nuclear Pore Complex (NPC) Disassembly, Nucleocytoplasmic transport - Mus musculus (mouse), Post-translational protein modification, Processing of Capped Intron-Containing Pre-mRNA, Regulation of Glucokinase by Glucokinase Regulatory Protein, Regulation of HSF1-mediated heat shock response, Regulation of mRNA stability by proteins that bind AU-rich elements, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, SUMOylation of DNA replication proteins, SUMOylation of RNA binding proteins, SUMOylation of SUMOylation proteins, SUMOylation of chromatin organization proteins, SUMOylation of ubiquitinylation proteins, Transcriptional regulation by small RNAs, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNA derived from an Intron-Containing Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, Transport of the SLBP Dependant Mature mRNA, Transport of the SLBP independent Mature mRNA, snRNP Assembly
UniProt: Q80U93
Entrez ID: 227720
|
Does Knockout of Serpinb3b in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
Serpinb3b
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Serpinb3b (serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: cysteine-type endopeptidase inhibitor activity, enzyme binding, peptidase inhibitor activity, protease binding, serine-type endopeptidase inhibitor activity, virus receptor activity; CC: cytoplasm, cytoplasmic vesicle, cytosol, extracellular exosome, extracellular space, nucleus, plasma membrane
Pathways: Amoebiasis - Mus musculus (mouse), Immune System, Innate Immune System, Neutrophil degranulation
UniProt: Q9D1Q5
Entrez ID: 383548
|
Does Knockout of Dnttip2 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,264
|
Knockout
|
Dnttip2
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Dnttip2 (deoxynucleotidyltransferase, terminal, interacting protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA processing, ribosomal small subunit biogenesis; CC: chromosome, nucleolus, nucleoplasm, nucleus, small-subunit processome
Pathways:
UniProt: Q8R2M2
Entrez ID: 99480
|
Does Knockout of Ccdc71 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Ccdc71
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Ccdc71 (coiled-coil domain containing 71)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q8VEG0
Entrez ID: 72454
|
Does Knockout of Chmp4b in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,264
|
Knockout
|
Chmp4b
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Chmp4b (charged multivesicular body protein 4B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagosome maturation, autophagy, exit from mitosis, late endosome to lysosome transport, late endosome to vacuole transport via multivesicular body sorting pathway, membrane fission, midbody abscission, mitotic cytokinesis, mitotic metaphase chromosome alignment, multivesicular body assembly, multivesicular body sorting pathway, multivesicular body-lysosome fusion, nuclear membrane reassembly, nucleus organization, plasma membrane repair, protein transport, regulation of autophagy, regulation of mitotic spindle assembly, ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway, vacuolar transport, vesicle budding from membrane, vesicle fusion with vacuole, viral budding from plasma membrane, viral budding via host ESCRT complex; MF: identical protein binding, protein binding, protein homodimerization activity; CC: ESCRT III complex, amphisome membrane, autophagosome membrane, cytoplasm, cytoplasmic side of plasma membrane, cytosol, endosome, endosome membrane, glutamatergic synapse, kinetochore, kinetochore microtubule, late endosome membrane, lysosomal membrane, membrane, membrane coat, midbody, multivesicular body, multivesicular body membrane, nuclear envelope, nuclear pore, nucleus, plasma membrane, postsynaptic density, vesicle
Pathways: Autophagy, Cell Cycle, Cell Cycle, Mitotic, Endocytosis - Mus musculus (mouse), Endosomal Sorting Complex Required For Transport (ESCRT), M Phase, Macroautophagy, Membrane Trafficking, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Necroptosis - Mus musculus (mouse), Nuclear Envelope (NE) Reassembly, Programmed Cell Death, Pyroptosis, Regulated Necrosis, Sealing of the nuclear envelope (NE) by ESCRT-III, Vesicle-mediated transport
UniProt: Q9D8B3
Entrez ID: 75608
|
Does Knockout of Nol4l in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Nol4l
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Nol4l (nucleolar protein 4-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cytosol, nucleoplasm
Pathways:
UniProt: Q3UH85, Q3TZG8, Q52KQ8
Entrez ID: 329540
|
Does Knockout of Fundc2 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Fundc2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Fundc2 (FUN14 domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagy of mitochondrion, intracellular triglyceride homeostasis, regulation of platelet activation; MF: phosphatidylinositol-3,4,5-trisphosphate binding; CC: membrane, mitochondrial outer membrane, mitochondrion, nucleus
Pathways:
UniProt: Q9D6K8
Entrez ID: 67391
|
Does Knockout of Cdr2l in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Cdr2l
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Cdr2l (cerebellar degeneration-related protein 2-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: identical protein binding, molecular_function
Pathways:
UniProt: A2A6T1
Entrez ID: 237988
|
Does Knockout of Ddx55 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,262
|
Knockout
|
Ddx55
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Ddx55 (DEAD box helicase 55)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: maturation of LSU-rRNA, rRNA processing, ribosome biogenesis; MF: ATP binding, ATP hydrolysis activity, RNA binding, RNA helicase activity, helicase activity, hydrolase activity, large ribosomal subunit rRNA binding, nucleic acid binding, nucleotide binding, rRNA binding; CC: cytosol, nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: Q6ZPL9
Entrez ID: 67848
|
Does Knockout of Mtrf1l in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Mtrf1l
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Mtrf1l (mitochondrial translational release factor 1-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial translational termination, translation, translational termination; MF: translation release factor activity, translation release factor activity, codon specific; CC: cytoplasm, mitochondrion
Pathways: Metabolism of proteins, Mitochondrial translation, Mitochondrial translation termination, Translation
UniProt: Q8BJU9
Entrez ID: 108853
|
Does Knockout of Neil3 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Neil3
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Neil3 (nei like 3 (E. coli))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, base-excision repair, interstrand cross-link repair, single strand break repair; MF: DNA N-glycosylase activity, DNA binding, DNA-(apurinic or apyrimidinic site) endonuclease activity, MCM complex binding, bubble DNA binding, catalytic activity, class I DNA-(apurinic or apyrimidinic site) endonuclease activity, damaged DNA binding, double-stranded DNA binding, hydrolase activity, hydrolase activity, acting on glycosyl bonds, hydrolase activity, hydrolyzing N-glycosyl compounds, lyase activity, metal ion binding, nucleic acid binding, single-stranded DNA binding, zinc ion binding; CC: chromosome, nucleoplasm, nucleus
Pathways: Base Excision Repair, Base excision repair - Mus musculus (mouse), Base-Excision Repair, AP Site Formation, Cleavage of the damaged purine, DNA Repair, Depurination, Recognition and association of DNA glycosylase with site containing an affected purine
UniProt: Q8K203
Entrez ID: 234258
|
Does Knockout of Schip1 in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
Schip1
|
cell cycle progression
|
breast epithelium
|
Gene: Schip1 (schwannomin interacting protein 1)
Type: protein-coding
Summary: Predicted to enable protein homodimerization activity. Acts upstream of or within several processes, including face morphogenesis; fibroblast migration; and luteinization. Predicted to be located in cytoplasm. Predicted to be active in cell junction and plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; sensory organ; and submandibular gland primordium. Orthologous to human SCHIP1 (schwannomin interacting protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: axon ensheathment, estrogen metabolic process, face morphogenesis, female gonad development, fibroblast migration, kidney development, luteinization, negative regulation of cytoskeleton organization, platelet-derived growth factor receptor signaling pathway, positive regulation of hippo signaling, post-embryonic development, roof of mouth development, skeletal system morphogenesis, smooth muscle tissue development; MF: ankyrin binding, calmodulin binding, identical protein binding, protein binding, protein homodimerization activity, transmembrane transporter binding; CC: axon, axon initial segment, cell junction, cell projection, cytoplasm, dendrite, node of Ranvier, plasma membrane
Pathways:
UniProt: P0DPB4
Entrez ID: 30953
|
Does Knockout of Tatdn2 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Tatdn2
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Tatdn2 (TatD DNase domain containing 2)
Type: protein-coding
Summary: Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut; and hemolymphoid system. Orthologous to human TATDN2 (TatD DNase domain containing 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: MF: hydrolase activity, acting on ester bonds, molecular_function
Pathways:
UniProt: F8VQE6, B7ZNL9, F7CWI0, F6W3K2
Entrez ID: 381801
|
Does Knockout of Clec2e in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Clec2e
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Clec2e (C-type lectin domain family 2, member e)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: carbohydrate binding, molecular_function, natural killer cell lectin-like receptor binding; CC: cell surface, endoplasmic reticulum, external side of plasma membrane, membrane, plasma membrane
Pathways:
UniProt: H7BWZ4
Entrez ID: 232409
|
Does Knockout of Nhej1 in Lymphoma Cell Line causally result in response to chemicals?
| 1
| 1,553
|
Knockout
|
Nhej1
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Nhej1 (non-homologous end joining factor 1)
Type: protein-coding
Summary: Predicted to enable DNA end binding activity and DNA polymerase binding activity. Involved in double-strand break repair via nonhomologous end joining. Predicted to be located in fibrillar center and nucleoplasm. Predicted to be part of DNA ligase IV complex and DNA-dependent protein kinase-DNA ligase 4 complex. Predicted to be active in site of double-strand break. Human ortholog(s) of this gene implicated in severe combined immunodeficiency 124. Orthologous to human NHEJ1 (non-homologous end joining factor 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: B cell differentiation, DNA damage response, DNA repair, T cell differentiation, double-strand break repair, double-strand break repair via nonhomologous end joining, immunoglobulin V(D)J recombination, response to ionizing radiation, telomere maintenance; MF: DNA binding, DNA end binding, DNA polymerase binding, protein binding; CC: DNA ligase IV complex, DNA-dependent protein kinase-DNA ligase 4 complex, chromosome, fibrillar center, nonhomologous end joining complex, nucleoplasm, nucleus, site of double-strand break
Pathways: DNA Double-Strand Break Repair, DNA Repair, Non-homologous end-joining - Mus musculus (mouse), Nonhomologous End-Joining (NHEJ)
UniProt: Q3KNJ2
Entrez ID: 75570
|
Does Knockout of Txndc12 in Embryonic Fibroblast Cell Line causally result in autophagy?
| 1
| 1,043
|
Knockout
|
Txndc12
|
autophagy
|
Embryonic Fibroblast Cell Line
|
Gene: Txndc12 (thioredoxin domain containing 12 (endoplasmic reticulum))
Type: protein-coding
Summary: Predicted to enable protein-disulfide reductase (glutathione) activity. Predicted to act upstream of or within negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway. Located in endoplasmic reticulum lumen. Is expressed in several structures, including alimentary system; brain; cranium; eye; and respiratory system. Orthologous to human TXNDC12 (thioredoxin domain containing 12). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; MF: oxidoreductase activity, protein-disulfide reductase (glutathione) activity, protein-disulfide reductase activity; CC: endoplasmic reticulum, endoplasmic reticulum lumen
Pathways: Glutathione metabolism - Mus musculus (mouse)
UniProt: Q9CQU0
Entrez ID: 66073
|
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.