prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Atad2b in Lung Cancer Cell Line causally result in tumorigenicity?
| 1
| 1,089
|
Knockout
|
Atad2b
|
tumorigenicity
|
Lung Cancer Cell Line
|
Gene: Atad2b (ATPase family, AAA domain containing 2B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: nucleosome assembly, nucleosome disassembly, transcription initiation-coupled chromatin remodeling; MF: ATP binding, ATP hydrolysis activity, chromatin binding, histone binding, histone reader activity, nucleotide binding; CC: nucleoplasm, nucleus
Pathways:
UniProt:
Entrez ID: 320817
|
Does Knockout of 4930449I24Rik in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
4930449I24Rik
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: 4930449I24Rik (RIKEN cDNA 4930449I24 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: guanyl-nucleotide exchange factor activity, molecular_function
Pathways:
UniProt: Q9D5E3
Entrez ID: 67410
|
Does Knockout of Ms4a8a in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Ms4a8a
|
cell cycle progression
|
breast epithelium
|
Gene: Ms4a8a (membrane-spanning 4-domains, subfamily A, member 8A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: membrane, plasma membrane
Pathways:
UniProt: Q99N10
Entrez ID: 64381
|
Does Knockout of Tpr in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Tpr
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Tpr (translocated promoter region, nuclear basket protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA export from nucleus, RNA import into nucleus, cell division, cellular response to heat, cellular response to interferon-alpha, mRNA export from nucleus, mRNA export from nucleus in response to heat stress, mRNA transport, mitotic spindle assembly checkpoint signaling, negative regulation of RNA export from nucleus, negative regulation of transcription by RNA polymerase II, negative regulation of translational initiation, nuclear matrix organization, nuclear pore complex assembly, nuclear pore organization, nucleocytoplasmic transport, positive regulation of heterochromatin formation, positive regulation of intracellular protein transport, positive regulation of mitotic cell cycle spindle assembly checkpoint, positive regulation of protein export from nucleus, positive regulation of protein import into nucleus, protein export from nucleus, protein import into nucleus, protein transport, regulation of mitotic sister chromatid separation, regulation of mitotic spindle assembly, regulation of protein import into nucleus, regulation of protein localization, regulation of protein stability, response to epidermal growth factor; MF: chromatin binding, dynein complex binding, heat shock protein binding, mRNA binding, mitogen-activated protein kinase binding, protein binding, protein homodimerization activity, protein-membrane adaptor activity, structural constituent of nuclear pore, tubulin binding; CC: chromosome, chromosome, centromeric region, cytoplasm, cytoplasmic dynein complex, cytoskeleton, kinetochore, membrane, mitotic spindle, nuclear envelope, nuclear inclusion body, nuclear membrane, nuclear periphery, nuclear pore, nuclear pore nuclear basket, nucleus, spindle
Pathways: Amyotrophic lateral sclerosis - Mus musculus (mouse), Cell Cycle, Cell Cycle, Mitotic, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Gene Silencing by RNA, Gene expression (Transcription), Glucose metabolism, Glycolysis, IP3 and IP4 transport between cytosol and nucleus, IP6 and IP7 transport between cytosol and nucleus, IPs transport between nucleus and cytosol, Inositol phosphate metabolism, M Phase, Metabolism, Metabolism of RNA, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of non-coding RNA, Metabolism of proteins, Mitotic Prophase, Nuclear Envelope Breakdown, Nuclear Pore Complex (NPC) Disassembly, Nucleocytoplasmic transport - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Post-translational protein modification, Processing of Capped Intron-Containing Pre-mRNA, Regulation of Glucokinase by Glucokinase Regulatory Protein, Regulation of HSF1-mediated heat shock response, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, SUMOylation of DNA replication proteins, SUMOylation of RNA binding proteins, SUMOylation of SUMOylation proteins, SUMOylation of chromatin organization proteins, SUMOylation of ubiquitinylation proteins, Thyroid cancer - Mus musculus (mouse), Transcriptional regulation by small RNAs, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNA derived from an Intron-Containing Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, Transport of the SLBP Dependant Mature mRNA, Transport of the SLBP independent Mature mRNA, snRNP Assembly
UniProt: F6ZDS4
Entrez ID: 108989
|
Does Knockout of 1700109H08Rik in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,681
|
Knockout
|
1700109H08Rik
|
protein/peptide distribution
|
myoblast cell line
|
Gene: 1700109H08Rik (RIKEN cDNA 1700109H08 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, regulation of signal transduction; MF: calcium ion binding, metal ion binding, molecular_function
Pathways:
UniProt: D6RH70, Q9D9C0, F6QJ46, F6YAH5
Entrez ID: 77036
|
Does Knockout of Tnfsf11 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Tnfsf11
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Tnfsf11 (tumor necrosis factor (ligand) superfamily, member 11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: animal organ morphogenesis, bone development, bone resorption, calcium ion homeostasis, calcium-mediated signaling, cell differentiation, cell surface receptor signaling pathway, cellular response to leukemia inhibitory factor, cytokine-mediated signaling pathway, immune response, lymph node development, mammary gland alveolus development, mammary gland epithelial cell proliferation, monocyte chemotaxis, negative regulation of transcription by RNA polymerase II, ossification, osteoclast development, osteoclast differentiation, osteoclast proliferation, paracrine signaling, positive regulation of ERK1 and ERK2 cascade, positive regulation of JNK cascade, positive regulation of MAPK cascade, positive regulation of T cell activation, positive regulation of bone resorption, positive regulation of canonical NF-kappaB signal transduction, positive regulation of corticotropin-releasing hormone secretion, positive regulation of extrinsic apoptotic signaling pathway, positive regulation of fever generation by positive regulation of prostaglandin secretion, positive regulation of gene expression, positive regulation of homotypic cell-cell adhesion, positive regulation of intracellular signal transduction, positive regulation of non-canonical NF-kappaB signal transduction, positive regulation of osteoclast development, positive regulation of osteoclast differentiation, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of transcription by RNA polymerase II, regulation of osteoclast differentiation, tooth eruption, tumor necrosis factor-mediated signaling pathway; MF: cytokine activity, identical protein binding, protein binding, receptor ligand activity, tumor necrosis factor receptor binding, tumor necrosis factor receptor superfamily binding; CC: cytoplasm, extracellular region, extracellular space, membrane, plasma membrane
Pathways: Breast cancer - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Cytokine-cytokine receptor interaction - Mus musculus (mouse), NF-kappa B signaling pathway - Mus musculus (mouse), Osteoclast differentiation - Mus musculus (mouse), Parathyroid hormone synthesis, secretion and action - Mus musculus (mouse), Prolactin signaling pathway - Mus musculus (mouse), Rheumatoid arthritis - Mus musculus (mouse)
UniProt: O35235
Entrez ID: 21943
|
Does Knockout of Dhh in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Dhh
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Dhh (desert hedgehog)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Leydig cell differentiation, Schwann cell development, cell fate specification, cell-cell signaling, developmental process involved in reproduction, intein-mediated protein splicing, male gonad development, male sex determination, myelination, osteoblast differentiation, paracrine signaling, positive regulation of smoothened signaling pathway, protein autoprocessing, proteolysis, regulation of gene expression, regulation of steroid biosynthetic process, response to estradiol, response to estrogen, self proteolysis, smoothened signaling pathway, spermatid development, spermatogenesis, system development; MF: calcium ion binding, cholesterol-protein transferase activity, hydrolase activity, metal ion binding, patched binding, peptidase activity, protein binding, transferase activity, zinc ion binding; CC: Golgi apparatus, Golgi membrane, endoplasmic reticulum, endoplasmic reticulum membrane, extracellular region, extracellular space, membrane, plasma membrane
Pathways: Activation of SMO, Hedgehog 'on' state, Hedgehog ligand biogenesis, Hedgehog signaling pathway - Mus musculus (mouse), Ligand-receptor interactions, Release of Hh-Np from the secreting cell, Signal Transduction, Signaling by Hedgehog
UniProt: Q61488
Entrez ID: 13363
|
Does Knockout of Esp5 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 83
|
Knockout
|
Esp5
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Esp5 (exocrine gland secreted peptide 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 102577427
|
Does Knockout of Ighmbp2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Ighmbp2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Ighmbp2 (immunoglobulin mu DNA binding protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of transcription by RNA polymerase II, neuromuscular process, spinal cord motor neuron differentiation, translation; MF: 5'-3' DNA helicase activity, 5'-3' RNA helicase activity, ATP binding, ATP hydrolysis activity, ATP-dependent activity, acting on DNA, ATP-dependent activity, acting on RNA, DNA binding, G-rich single-stranded DNA binding, RNA binding, RNA helicase activity, double-stranded DNA helicase activity, general transcription initiation factor binding, helicase activity, hydrolase activity, identical protein binding, metal ion binding, nucleic acid binding, nucleotide binding, ribosome binding, single-stranded DNA binding, single-stranded RNA binding, tRNA binding, zinc ion binding; CC: axon, cell projection, cytoplasm, cytosol, growth cone, neuronal cell body, nuclear body, nucleoplasm, nucleus, perinuclear region of cytoplasm, ribonucleoprotein complex
Pathways:
UniProt: D6RFT3, A0A0B4J1E3, D3Z5P5
Entrez ID: 20589
|
Does Knockout of Pappa in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Pappa
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Pappa (pregnancy-associated plasma protein A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell surface receptor signaling pathway, protein catabolic process, proteolysis, response to dexamethasone; MF: endopeptidase activity, hydrolase activity, metal ion binding, metalloendopeptidase activity, metallopeptidase activity, peptidase activity; CC: extracellular region, extracellular space
Pathways: Metabolism of proteins, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
UniProt: Q8R4K8
Entrez ID: 18491
|
Does Knockout of Fbxw11 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Fbxw11
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Fbxw11 (F-box and WD-40 domain protein 11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, Wnt signaling pathway, brain morphogenesis, establishment of mitotic spindle orientation, germ cell development, microtubule organizing center organization, negative regulation of canonical NF-kappaB signal transduction, negative regulation of non-canonical NF-kappaB signal transduction, nuclear migration, positive regulation of DNA-templated transcription, positive regulation of canonical NF-kappaB signal transduction, positive regulation of circadian rhythm, positive regulation of proteolysis, proteasome-mediated ubiquitin-dependent protein catabolic process, protein dephosphorylation, protein destabilization, protein polyubiquitination, protein ubiquitination, regulation of circadian rhythm, retrograde axonal transport, rhythmic process, vesicle transport along microtubule; MF: dynein complex binding, microtubule plus-end binding, protein binding, protein dimerization activity, ubiquitin protein ligase activity, ubiquitin-like ligase-substrate adaptor activity, ubiquitin-protein transferase activity; CC: SCF ubiquitin ligase complex, axon cytoplasm, centrosome, cytoplasm, cytoplasmic microtubule, cytosol, kinetochore, microtubule associated complex, neuron projection, neuronal cell body, nuclear envelope, nucleus
Pathways: Activation of NF-kappaB in B cells, Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, C-type lectin receptors (CLRs), CLEC7A (Dectin-1) signaling, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cellular senescence - Mus musculus (mouse), Circadian rhythm - Mus musculus (mouse), Class I MHC mediated antigen processing & presentation, Cytokine Signaling in Immune system, Dectin-1 mediated noncanonical NF-kB signaling, Downstream TCR signaling, Downstream signaling events of B Cell Receptor (BCR), FCERI mediated NF-kB activation, Fc epsilon receptor (FCERI) signaling, G1/S DNA Damage Checkpoints, G2/M Transition, Hedgehog signaling pathway - Mus musculus (mouse), Hippo signaling pathway - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Immune System, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, Interleukin-17 signaling, MAP kinase activation, MAP3K8 (TPL2)-dependent MAPK1/3 activation, Metabolism of proteins, Mitotic G2-G2/M phases, MyD88 cascade initiated on plasma membrane, MyD88 dependent cascade initiated on endosome, MyD88-independent TLR4 cascade , MyD88:MAL(TIRAP) cascade initiated on plasma membrane, NIK-->noncanonical NF-kB signaling, Neddylation, Oocyte meiosis - Mus musculus (mouse), Post-translational protein modification, Regulation of PLK1 Activity at G2/M Transition, Signaling by Interleukins, Signaling by the B Cell Receptor (BCR), TCR signaling, TNFR2 non-canonical NF-kB pathway, TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, TRIF (TICAM1)-mediated TLR4 signaling , Toll Like Receptor 10 (TLR10) Cascade, Toll Like Receptor 2 (TLR2) Cascade, Toll Like Receptor 3 (TLR3) Cascade, Toll Like Receptor 4 (TLR4) Cascade, Toll Like Receptor 5 (TLR5) Cascade, Toll Like Receptor 7/8 (TLR7/8) Cascade, Toll Like Receptor 9 (TLR9) Cascade, Toll Like Receptor TLR1:TLR2 Cascade, Toll Like Receptor TLR6:TLR2 Cascade, Toll-like Receptor Cascades, Ubiquitin mediated proteolysis - Mus musculus (mouse), Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, Wnt signaling pathway - Mus musculus (mouse), p53-Independent G1/S DNA Damage Checkpoint
UniProt: Q5SRY7
Entrez ID: 103583
|
Does Knockout of Trim12c in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Trim12c
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Trim12c (tripartite motif-containing 12C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: activation of innate immune response, autophagy, host-mediated suppression of symbiont invasion, innate immune response, positive regulation of MAPK cascade, positive regulation of canonical NF-kappaB signal transduction, protein K63-linked ubiquitination, regulation of gene expression, regulation of lipopolysaccharide-mediated signaling pathway, regulation of protein localization, regulation of viral entry into host cell, suppression of viral release by host; MF: identical protein binding, metal ion binding, pattern recognition receptor activity, protein homodimerization activity, protein kinase binding, protein-macromolecule adaptor activity, transcription coactivator activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: P-body, cytoplasm, omegasome
Pathways: Human immunodeficiency virus 1 infection - Mus musculus (mouse)
UniProt: D3Z3L3
Entrez ID: 319236
|
Does Knockout of Vmn1r15 in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Vmn1r15
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Vmn1r15 (vomeronasal 1 receptor 15)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled receptor activity, pheromone binding, pheromone receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: Q14C10
Entrez ID: 113863
|
Does Knockout of Nmd3 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 579
|
Knockout
|
Nmd3
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Nmd3 (NMD3 ribosome export adaptor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of RNA biosynthetic process, positive regulation of protein localization to nucleolus, protein transport, ribosomal large subunit export from nucleus; MF: protein-macromolecule adaptor activity, ribosomal large subunit binding; CC: cytoplasm, nucleolus, nucleoplasm, nucleus
Pathways: Nucleocytoplasmic transport - Mus musculus (mouse), Ribosome biogenesis in eukaryotes - Mus musculus (mouse)
UniProt: Q99L48
Entrez ID: 97112
|
Does Knockout of Psmc6 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Psmc6
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Psmc6 (proteasome (prosome, macropain) 26S subunit, ATPase, 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ERAD pathway, positive regulation of RNA polymerase II transcription preinitiation complex assembly, positive regulation of inclusion body assembly, proteasome-mediated ubiquitin-dependent protein catabolic process; MF: ATP binding, ATP hydrolysis activity, identical protein binding, nucleotide binding, proteasome-activating activity; CC: cytoplasm, cytosolic proteasome complex, inclusion body, nucleus, proteasome accessory complex, proteasome complex, proteasome regulatory particle, base subcomplex
Pathways: ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, AUF1 (hnRNP D0) binds and destabilizes mRNA, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Activation of NF-kappaB in B cells, Adaptive Immune System, Adherens junctions interactions, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Antigen processing-Cross presentation, Antigen processing: Ubiquitination & Proteasome degradation, Assembly of the pre-replicative complex, Asymmetric localization of PCP proteins, Autodegradation of Cdh1 by Cdh1:APC/C, Autodegradation of the E3 ubiquitin ligase COP1, Beta-catenin independent WNT signaling, C-type lectin receptors (CLRs), CDK-mediated phosphorylation and removal of Cdc6, CLEC7A (Dectin-1) signaling, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cellular response to chemical stress, Cellular response to hypoxia, Cellular responses to stimuli, Cellular responses to stress, Circadian clock, Class I MHC mediated antigen processing & presentation, Co-inhibition by PD-1, Cross-presentation of soluble exogenous antigens (endosomes), Cyclin A:Cdk2-associated events at S phase entry, Cyclin E associated events during G1/S transition , Cytokine Signaling in Immune system, DNA Replication, DNA Replication Pre-Initiation, Dectin-1 mediated noncanonical NF-kB signaling, Degradation of AXIN, Degradation of CDH1, Degradation of CRY and PER proteins, Degradation of DVL, Degradation of GLI1 by the proteasome, Degradation of beta-catenin by the destruction complex, Deubiquitination, Downstream TCR signaling, Downstream signaling events of B Cell Receptor (BCR), Epstein-Barr virus infection - Mus musculus (mouse), FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, FCERI mediated NF-kB activation, Fc epsilon receptor (FCERI) signaling, G1/S DNA Damage Checkpoints, G1/S Transition, G2/M Checkpoints, G2/M Transition, GLI3 is processed to GLI3R by the proteasome, GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2, GSK3B-mediated proteasomal degradation of PD-L1(CD274), Gene expression (Transcription), Generic Transcription Pathway, Hedgehog 'off' state, Hedgehog 'on' state, Hedgehog ligand biogenesis, Huntington disease - Mus musculus (mouse), Immune System, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, Intracellular signaling by second messengers, KEAP1-NFE2L2 pathway, M Phase, MAPK family signaling cascades, MAPK1/MAPK3 signaling, MAPK6/MAPK4 signaling, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of polyamines, Metabolism of proteins, Mitotic Anaphase, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, NIK-->noncanonical NF-kB signaling, Neddylation, Nuclear events mediated by NFE2L2, Orc1 removal from chromatin, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, PCP/CE pathway, PIP3 activates AKT signaling, PTEN Regulation, Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Post-translational protein modification, Prion disease - Mus musculus (mouse), Proteasome - Mus musculus (mouse), Proteasome assembly, RAF/MAP kinase cascade, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of PTEN stability and activity, Regulation of RAS by GAPs, Regulation of RUNX2 expression and activity, Regulation of RUNX3 expression and activity, Regulation of T cell activation by CD28 family, Regulation of mRNA stability by proteins that bind AU-rich elements, Regulation of mitotic cell cycle, Regulation of ornithine decarboxylase (ODC), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, S Phase, SCF(Skp2)-mediated degradation of p27/p21, SPOP-mediated proteasomal degradation of PD-L1(CD274), Separation of Sister Chromatids, Signal Transduction, Signaling by Hedgehog, Signaling by Interleukins, Signaling by WNT, Signaling by the B Cell Receptor (BCR), Spinocerebellar ataxia - Mus musculus (mouse), Stabilization of p53, Switching of origins to a post-replicative state, Synthesis of DNA, TCF dependent signaling in response to WNT, TCR signaling, TNFR2 non-canonical NF-kB pathway, Targeted protein degradation, The role of GTSE1 in G2/M progression after G2 checkpoint, Transcriptional regulation by RUNX1, Transcriptional regulation by RUNX2, Transcriptional regulation by RUNX3, Translation, Transport of small molecules, UCH proteinases, Ub-specific processing proteases, Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, Ubiquitin-dependent degradation of Cyclin D, p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint, p53-Independent G1/S DNA Damage Checkpoint
UniProt: P62334
Entrez ID: 67089
|
Does Knockout of Rev1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Rev1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Rev1 (REV1, DNA directed polymerase)
Type: protein-coding
Summary: Enables deoxycytidyl transferase activity. Acts upstream of or within error-prone translesion synthesis. Predicted to be located in nucleus. Orthologous to human REV1 (REV1 DNA directed polymerase). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: DNA biosynthetic process, DNA damage response, DNA metabolic process, DNA repair, error-free translesion synthesis, error-prone translesion synthesis, response to UV, somatic hypermutation of immunoglobulin genes, translesion synthesis; MF: DNA binding, DNA-directed DNA polymerase activity, damaged DNA binding, deoxycytidyl transferase activity, metal ion binding, nucleotidyltransferase activity, protein binding, protein-macromolecule adaptor activity, transferase activity, ubiquitin binding; CC: nuclear replication fork, nucleus, site of DNA damage
Pathways: DNA Damage Bypass, DNA Repair, Fanconi anemia pathway - Mus musculus (mouse), Termination of translesion DNA synthesis, Translesion synthesis by POLI, Translesion synthesis by POLK, Translesion synthesis by REV1, Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
UniProt: Q920Q2
Entrez ID: 56210
|
Does Knockout of Rbfa in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,681
|
Knockout
|
Rbfa
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Rbfa (ribosome binding factor A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, mitochondrion
Pathways:
UniProt: Q6P3B9
Entrez ID: 68731
|
Does Knockout of Pdcd2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Pdcd2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Pdcd2 (programmed cell death 2)
Type: protein-coding
Summary: Predicted to enable enzyme binding activity. Predicted to be involved in positive regulation of apoptotic process; positive regulation of hematopoietic stem cell proliferation; and regulation of hematopoietic progenitor cell differentiation. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in cranial ganglion; cranial nerve; and dorsal root ganglion. Orthologous to human PDCD2 (programmed cell death 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: apoptotic process, positive regulation of apoptotic process, positive regulation of hematopoietic stem cell proliferation, programmed cell death, regulation of hematopoietic progenitor cell differentiation; MF: DNA binding, enzyme binding, metal ion binding, zinc ion binding; CC: cytoplasm, nucleus
Pathways:
UniProt: P46718
Entrez ID: 18567
|
Does Knockout of Prl3a1 in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
Prl3a1
|
cell cycle progression
|
breast epithelium
|
Gene: Prl3a1 (prolactin family 3, subfamily a, member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell surface receptor signaling pathway, female pregnancy, mammary gland development, positive regulation of lactation, positive regulation of receptor signaling pathway via JAK-STAT, response to nutrient levels; MF: hormone activity, prolactin receptor binding; CC: extracellular region, extracellular space
Pathways:
UniProt: Q78Y73
Entrez ID: 67000
|
Does Knockout of Trim52 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Trim52
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Trim52 (tripartite motif-containing 52)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: defense response to virus, innate immune response, positive regulation of canonical NF-kappaB signal transduction, protein autoubiquitination, protein ubiquitination; MF: metal ion binding, transcription coactivator activity, ubiquitin protein ligase activity, zinc ion binding; CC: cytoplasm, cytosol, nucleus
Pathways:
UniProt: Q8CDV4
Entrez ID: 212085
|
Does Knockout of Btbd35f1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Btbd35f1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Btbd35f1 (BTB domain containing 35, family member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, cell differentiation, germ cell development, protein ubiquitination, spermatogenesis; CC: nuclear matrix, nucleus
Pathways:
UniProt: A0A571BEF3
Entrez ID: 71847
|
Does Knockout of Pold4 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Pold4
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Pold4 (polymerase (DNA-directed), delta 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, DNA replication, DNA synthesis involved in DNA repair, DNA-templated DNA replication, positive regulation of endothelial cell proliferation; CC: delta DNA polymerase complex, nucleus
Pathways: Base Excision Repair, Base excision repair - Mus musculus (mouse), Cell Cycle, Cell Cycle, Mitotic, Chromosome Maintenance, DNA Damage Bypass, DNA Double-Strand Break Repair, DNA Repair, DNA Replication, DNA replication - Mus musculus (mouse), DNA strand elongation, Dual Incision in GG-NER, Dual incision in TC-NER, Extension of Telomeres, Gap-filling DNA repair synthesis and ligation in GG-NER, Gap-filling DNA repair synthesis and ligation in TC-NER, Global Genome Nucleotide Excision Repair (GG-NER), HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homologous recombination - Mus musculus (mouse), Homology Directed Repair, Lagging Strand Synthesis, Leading Strand Synthesis, Mismatch Repair, Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta), Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha), Mismatch repair - Mus musculus (mouse), Nucleotide Excision Repair, Nucleotide excision repair - Mus musculus (mouse), PCNA-Dependent Long Patch Base Excision Repair, Polymerase switching, Polymerase switching on the C-strand of the telomere, Processive synthesis on the C-strand of the telomere, Processive synthesis on the lagging strand, Recognition of DNA damage by PCNA-containing replication complex, Removal of the Flap Intermediate, Removal of the Flap Intermediate from the C-strand, Resolution of AP sites via the multiple-nucleotide patch replacement pathway, Resolution of Abasic Sites (AP sites), S Phase, Synthesis of DNA, Telomere C-strand (Lagging Strand) Synthesis, Telomere Maintenance, Termination of translesion DNA synthesis, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
UniProt: Q9CWP8
Entrez ID: 69745
|
Does Knockout of Ppp1r1a in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,681
|
Knockout
|
Ppp1r1a
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Ppp1r1a (protein phosphatase 1, regulatory inhibitor subunit 1A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: glycogen metabolic process, intracellular signal transduction, signal transduction; MF: protein binding, protein phosphatase inhibitor activity; CC: cytoplasm, extracellular space
Pathways: Adrenergic signaling in cardiomyocytes - Mus musculus (mouse), Long-term potentiation - Mus musculus (mouse)
UniProt: Q9ERT9
Entrez ID: 58200
|
Does Knockout of Dapl1 in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
Dapl1
|
cell cycle progression
|
breast epithelium
|
Gene: Dapl1 (death associated protein-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, apoptotic signaling pathway, cell differentiation, cell population proliferation, gene expression, negative regulation of CD8-positive, alpha-beta T cell activation, negative regulation of autophagy, ribosome hibernation; MF: ribosome binding, translation initiation factor binding, translation repressor activity; CC: cellular_component, nucleus
Pathways:
UniProt: Q9D757
Entrez ID: 76747
|
Does Knockout of Taar5 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Taar5
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Taar5 (trace amine-associated receptor 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, adenylate cyclase-activating G protein-coupled receptor signaling pathway, cell surface receptor signaling pathway, cognition, mating behavior, sensory perception of chemical stimulus, signal transduction, social behavior; MF: G protein-coupled amine receptor activity, G protein-coupled receptor activity, trace-amine receptor activity, transmembrane signaling receptor activity, trimethylamine receptor activity; CC: membrane, plasma membrane
Pathways: Amine ligand-binding receptors, Class A/1 (Rhodopsin-like receptors), G alpha (s) signalling events, GPCR downstream signalling, GPCR ligand binding, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Signal Transduction, Signaling by GPCR
UniProt: Q5QD14
Entrez ID: 215854
|
Does Knockout of Camk2a in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Camk2a
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Camk2a (calcium/calmodulin-dependent protein kinase II alpha)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G1/S transition of mitotic cell cycle, angiotensin-activated signaling pathway, calcium ion transport, cell surface receptor signaling pathway via JAK-STAT, cellular response to interferon-beta, cellular response to type II interferon, dendrite morphogenesis, dendritic spine development, ionotropic glutamate receptor signaling pathway, negative regulation of ferroptosis, negative regulation of hydrolase activity, neurotransmitter receptor transport to plasma membrane, peptidyl-threonine autophosphorylation, positive regulation of calcium ion transport, positive regulation of cardiac muscle cell apoptotic process, positive regulation of receptor signaling pathway via JAK-STAT, regulation of endocannabinoid signaling pathway, regulation of mitochondrial membrane permeability involved in apoptotic process, regulation of neuron migration, regulation of neuronal synaptic plasticity, regulation of neurotransmitter receptor localization to postsynaptic specialization membrane, regulation of neurotransmitter secretion, regulation of protein localization to plasma membrane, regulation of synaptic vesicle docking, response to ischemia; MF: ATP binding, GTPase activating protein binding, calcium/calmodulin-dependent protein kinase activity, calmodulin binding, glutamate receptor binding, identical protein binding, kinase activity, metal ion binding, nucleotide binding, protein binding, protein homodimerization activity, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: Schaffer collateral - CA1 synapse, axon, calcium- and calmodulin-dependent protein kinase complex, cell projection, cytoplasm, dendrite, dendrite cytoplasm, dendritic spine, glutamatergic synapse, mitochondrion, neuron projection, neuronal cell body, organelle, postsynaptic cytosol, postsynaptic density, presynaptic cytosol, synapse
Pathways: Activation of NMDA receptors and postsynaptic events, Adrenergic signaling in cardiomyocytes - Mus musculus (mouse), Aldosterone synthesis and secretion - Mus musculus (mouse), Amphetamine addiction - Mus musculus (mouse), Axon guidance - Mus musculus (mouse), Beta-catenin independent WNT signaling, Ca2+ pathway, Calcium signaling pathway - Mus musculus (mouse), Cardiac conduction, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Cholinergic synapse - Mus musculus (mouse), Circadian entrainment - Mus musculus (mouse), Cushing syndrome - Mus musculus (mouse), Cytokine Signaling in Immune system, Diabetic cardiomyopathy - Mus musculus (mouse), Dopaminergic synapse - Mus musculus (mouse), ErbB signaling pathway - Mus musculus (mouse), Gastric acid secretion - Mus musculus (mouse), Glioma - Mus musculus (mouse), Glucagon signaling pathway - Mus musculus (mouse), Glutamate binding, activation of AMPA receptors and synaptic plasticity, GnRH signaling pathway - Mus musculus (mouse), HIF-1 signaling pathway - Mus musculus (mouse), HSF1-dependent transactivation, Immune System, Inflammatory mediator regulation of TRP channels - Mus musculus (mouse), Insulin secretion - Mus musculus (mouse), Interferon Signaling, Interferon gamma signaling, Ion channel transport, Ion homeostasis, Ion transport by P-type ATPases, Lipid and atherosclerosis - Mus musculus (mouse), Long-term potentiation - Mus musculus (mouse), MAPK family signaling cascades, MAPK1/MAPK3 signaling, Melanogenesis - Mus musculus (mouse), Muscle contraction, Necroptosis - Mus musculus (mouse), Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, Neurotrophin signaling pathway - Mus musculus (mouse), Olfactory transduction - Mus musculus (mouse), Oocyte meiosis - Mus musculus (mouse), Oxytocin signaling pathway - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Proteoglycans in cancer - Mus musculus (mouse), RAF activation, RAF/MAP kinase cascade, Signal Transduction, Signaling by WNT, Trafficking of AMPA receptors, Transmission across Chemical Synapses, Transport of small molecules, Tuberculosis - Mus musculus (mouse), Unblocking of NMDA receptors, glutamate binding and activation, Wnt signaling pathway - Mus musculus (mouse), cAMP signaling pathway - Mus musculus (mouse)
UniProt: P11798
Entrez ID: 12322
|
Does Knockout of Magoh in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Magoh
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Magoh (mago homolog, exon junction complex core component)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, female gamete generation, mRNA export from nucleus, mRNA processing, mRNA splicing, via spliceosome, mRNA transport, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, regulation of alternative mRNA splicing, via spliceosome, regulation of mRNA processing, regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, regulation of translation; CC: catalytic step 2 spliceosome, cytoplasm, cytosol, exon-exon junction complex, exon-exon junction subcomplex mago-y14, nuclear speck, nucleus, spliceosomal complex
Pathways: Gene expression (Transcription), Metabolism of RNA, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), Nucleocytoplasmic transport - Mus musculus (mouse), Processing of Capped Intron-Containing Pre-mRNA, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, Spliceosome - Mus musculus (mouse), Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA derived from an Intron-Containing Transcript, mRNA 3'-end processing, mRNA Splicing, mRNA Splicing - Major Pathway, mRNA surveillance pathway - Mus musculus (mouse)
UniProt: P61327
Entrez ID: 17149
|
Does Knockout of Xrcc1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Xrcc1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Xrcc1 (X-ray repair complementing defective repair in Chinese hamster cells 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, base-excision repair, double-strand break repair, double-strand break repair via nonhomologous end joining, hippocampus development, negative regulation of protection from non-homologous end joining at telomere, regulation of base-excision repair, response to hydroperoxide, single strand break repair, telomeric DNA-containing double minutes formation; MF: 3' overhang single-stranded DNA endodeoxyribonuclease activity, ADP-D-ribose modification-dependent protein binding, damaged DNA binding, enzyme binding, oxidized DNA binding, poly-ADP-D-ribose binding; CC: ERCC4-ERCC1 complex, chromatin, chromosome, chromosome, telomeric region, nucleolus, nucleoplasm, nucleus, site of DNA damage
Pathways: APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway, Base Excision Repair, Base excision repair - Mus musculus (mouse), DNA Double-Strand Break Repair, DNA Repair, Gap-filling DNA repair synthesis and ligation in TC-NER, HDR through MMEJ (alt-NHEJ), Homology Directed Repair, Nucleotide Excision Repair, Resolution of AP sites via the single-nucleotide replacement pathway, Resolution of Abasic Sites (AP sites), Transcription-Coupled Nucleotide Excision Repair (TC-NER)
UniProt: Q60596
Entrez ID: 22594
|
Does Knockout of Pdf in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
Pdf
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Pdf (peptide deformylase (mitochondrial))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of cell population proliferation, post-translational protein modification, translation; MF: hydrolase activity, metal ion binding, peptide deformylase activity; CC: mitochondrion
Pathways:
UniProt: S4R2K0
Entrez ID: 68023
|
Does Knockout of Pcsk7 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,172
|
Knockout
|
Pcsk7
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Pcsk7 (proprotein convertase subtilisin/kexin type 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein processing, proteolysis; MF: hydrolase activity, peptidase activity, serine-type endopeptidase activity, serine-type peptidase activity; CC: Golgi apparatus, Golgi membrane, endoplasmic reticulum lumen, membrane, trans-Golgi network
Pathways: Adherens junctions interactions, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Regulation of CDH1 Expression and Function, Regulation of CDH1 posttranslational processing and trafficking to plasma membrane, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion
UniProt: Q61139
Entrez ID: 18554
|
Does Knockout of Urb2 in Microglial Cell Line causally result in protein/peptide distribution?
| 1
| 1,585
|
Knockout
|
Urb2
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Urb2 (URB2 ribosome biogenesis 2 homolog (S. cerevisiae))
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: aggresome, midbody, nucleolus
Pathways:
UniProt: G3UX45, E9Q7L1
Entrez ID: 382038
|
Does Knockout of Prkrip1 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Prkrip1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Prkrip1 (Prkr interacting protein 1 (IL11 inducible))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, mRNA processing, renal system process; MF: double-stranded RNA binding, protein binding, protein kinase binding, protein kinase inhibitor activity; CC: nucleolus, nucleus, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q9CWV6
Entrez ID: 66801
|
Does Knockout of Cadps2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
Cadps2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Cadps2 (Ca2+-dependent activator protein for secretion 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to starvation, dense core granule exocytosis, exocytosis, hematopoietic stem cell homeostasis, positive regulation of exocytosis, protein transport, regulated exocytosis, synaptic vesicle exocytosis, synaptic vesicle priming; MF: lipid binding, metal ion binding, protein binding; CC: cell projection, centrosome, ciliary basal body, cilium, cytoplasm, cytoplasmic vesicle, cytoplasmic vesicle membrane, cytoskeleton, glutamatergic synapse, membrane, nucleoplasm, parallel fiber to Purkinje cell synapse, postsynaptic membrane, presynapse, presynaptic membrane, synapse
Pathways:
UniProt: Q8BYR5
Entrez ID: 320405
|
Does Knockout of Ttll5 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Ttll5
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Ttll5 (tubulin tyrosine ligase-like family, member 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: fertilization, flagellated sperm motility, retina development in camera-type eye, sperm axoneme assembly, spermatogenesis; MF: ATP binding, ligase activity, metal ion binding, nucleotide binding, protein-glutamic acid ligase activity, elongating, protein-glutamic acid ligase activity, initiating, tubulin binding, tubulin-glutamic acid ligase activity; CC: 9+0 non-motile cilium, cell projection, centrosome, ciliary basal body, cilium, cytoplasm, cytoskeleton, cytosol, microtubule, nucleus, plasma membrane
Pathways: Carboxyterminal post-translational modifications of tubulin, Metabolism of proteins, Post-translational protein modification
UniProt: Q8CHB8
Entrez ID: 320244
|
Does Knockout of Lhfpl1 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Lhfpl1
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Lhfpl1 (lipoma HMGIC fusion partner-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: membrane
Pathways:
UniProt: Q80SV1
Entrez ID: 237091
|
Does Knockout of Atat1 in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Atat1
|
cell cycle progression
|
breast epithelium
|
Gene: Atat1 (alpha tubulin acetyltransferase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: alpha-tubulin acetylation, dentate gyrus development, microtubule cytoskeleton organization, neuron development, positive regulation of NLRP3 inflammasome complex assembly, regulation of fat cell differentiation, regulation of microtubule cytoskeleton organization, response to mechanical stimulus, response to pain, spermatogenesis; MF: L-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor, acetyltransferase activity, acyltransferase activity, transferase activity, tubulin N-acetyltransferase activity; CC: Golgi apparatus, anchoring junction, axon, cell projection, clathrin-coated pit, cytoplasm, cytoskeleton, cytosol, focal adhesion, membrane, microtubule, microtubule bundle, mitotic spindle, spindle
Pathways: Cargo trafficking to the periciliary membrane, Cilium Assembly, Organelle biogenesis and maintenance
UniProt: Q8K341
Entrez ID: 73242
|
Does Knockout of Rpgrip1 in Regulatory T cell causally result in cell proliferation?
| 1
| 2,127
|
Knockout
|
Rpgrip1
|
cell proliferation
|
Regulatory T cell
|
Gene: Rpgrip1 (retinitis pigmentosa GTPase regulator interacting protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: camera-type eye development, eye photoreceptor cell development, neural precursor cell proliferation, non-motile cilium assembly, retina development in camera-type eye, retinal rod cell development, visual perception; CC: axoneme, cell projection, ciliary rootlet, ciliary transition zone, cilium, cytoplasm, cytoskeleton, cytosol, intercellular bridge, microtubule cytoskeleton, neuron projection, non-motile cilium, photoreceptor connecting cilium, photoreceptor distal connecting cilium
Pathways:
UniProt: Q9EPQ2
Entrez ID: 77945
|
Does Knockout of Itfg1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Itfg1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Itfg1 (integrin alpha FG-GAP repeat containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: molecular_function, protein binding; CC: extracellular region, membrane, plasma membrane
Pathways:
UniProt: Q99KW9
Entrez ID: 71927
|
Does Knockout of Trim27 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Trim27
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Trim27 (tripartite motif-containing 27)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Arp2/3 complex-mediated actin nucleation, innate immune response, negative regulation of autophagy, negative regulation of gene expression, epigenetic, negative regulation of transcription by RNA polymerase II, negative regulation of type I interferon production, negative regulation of viral transcription, positive regulation of DNA-templated transcription, positive regulation of actin nucleation, positive regulation of autophagy, positive regulation of type I interferon production, protein K63-linked ubiquitination, protein ubiquitination, retrograde transport, endosome to Golgi, suppression of viral release by host; MF: DNA binding, SUMO transferase activity, identical protein binding, metal ion binding, phosphatidylinositol 3-kinase inhibitor activity, protein binding, transcription coactivator activity, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: PML body, cytoplasm, cytosol, early endosome, endosome, fibrillar center, mitochondrion, nuclear membrane, nucleolus, nucleoplasm, nucleus, retromer complex
Pathways: Intracellular signaling by second messengers, Metabolism of proteins, PIP3 activates AKT signaling, PTEN Regulation, Post-translational protein modification, Regulation of PTEN stability and activity, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of ubiquitinylation proteins, Signal Transduction
UniProt: Q62158
Entrez ID: 19720
|
Does Knockout of Zxdb in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Zxdb
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Zxdb (zinc finger, X-linked, duplicated B)
Type: protein-coding
Summary: Predicted to enable C2H2 zinc finger domain binding activity and transcription coactivator activity. Predicted to be involved in positive regulation of DNA-templated transcription and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in genitourinary system. Orthologous to human ZXDA (zinc finger X-linked duplicated A) and ZXDB (zinc finger X-linked duplicated B). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: positive regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: C2H2 zinc finger domain binding, metal ion binding, transcription coactivator activity, transcription coregulator activity, zinc ion binding; CC: nucleus
Pathways:
UniProt: A2CE44
Entrez ID: 668166
|
Does Knockout of Gchfr in Microglial Cell Line causally result in response to virus?
| 0
| 2,429
|
Knockout
|
Gchfr
|
response to virus
|
Microglial Cell Line
|
Gene: Gchfr (GTP cyclohydrolase I feedback regulator)
Type: protein-coding
Summary: Enables GTP cyclohydrolase I regulator activity and enzyme inhibitor activity. Involved in negative regulation of small molecule metabolic process. Predicted to be located in dendrite; melanosome; and nucleus. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm and nucleus. Is expressed in dorsal raphe nucleus; medulla oblongata basal plate marginal layer; midbrain mantle layer; and pons marginal layer. Orthologous to human GCHFR (GTP cyclohydrolase I feedback regulator). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: negative regulation of biosynthetic process, negative regulation of small molecule metabolic process, protein-containing complex assembly; MF: GTP cyclohydrolase I regulator activity, GTP cyclohydrolase binding, GTP-dependent protein binding, amino acid binding, enzyme inhibitor activity, identical protein binding, protein-containing complex binding; CC: cytoplasm, cytosol, dendrite, intracellular protein-containing complex, melanosome, membrane, nuclear membrane, nucleoplasm, nucleus, protein-containing complex
Pathways: Metabolism, Metabolism of cofactors, Metabolism of vitamins and cofactors, Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
UniProt: P99025
Entrez ID: 320415
|
Does Knockout of Rab6a in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Rab6a
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Rab6a (RAB6A, member RAS oncogene family)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: antigen processing and presentation, early endosome to Golgi transport, intra-Golgi vesicle-mediated transport, intracellular protein transport, protein localization to Golgi apparatus, protein localization to Golgi membrane, protein transport, retrograde transport, endosome to Golgi, retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum, vesicle-mediated transport; MF: ATPase activator activity, ATPase binding, G protein activity, GTP binding, GTPase activity, hydrolase activity, metal ion binding, myosin V binding, nucleotide binding, protein binding, protein domain specific binding; CC: Golgi apparatus, Golgi membrane, acrosomal membrane, centrosome, ciliary basal body, cytoplasmic vesicle, cytosol, endomembrane system, endosome to plasma membrane transport vesicle, membrane, nucleoplasm, presynapse, trans-Golgi network
Pathways: COPI-independent Golgi-to-ER retrograde traffic, Golgi-to-ER retrograde transport, Immune System, Innate Immune System, Intra-Golgi and retrograde Golgi-to-ER traffic, Membrane Trafficking, Metabolism of proteins, Neutrophil degranulation, Post-translational protein modification, RAB GEFs exchange GTP for GDP on RABs, RAB geranylgeranylation, Rab regulation of trafficking, Retrograde transport at the Trans-Golgi-Network, TBC/RABGAPs, Vesicle-mediated transport
UniProt: P35279
Entrez ID: 19346
|
Does Knockout of Pcp4l1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,271
|
Knockout
|
Pcp4l1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Pcp4l1 (Purkinje cell protein 4-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q6W8Q3
Entrez ID: 66425
|
Does Knockout of Hspd1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,262
|
Knockout
|
Hspd1
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Hspd1 (heat shock protein 1 (chaperonin))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell activation, B cell proliferation, MyD88-dependent toll-like receptor signaling pathway, T cell activation, adhesion of symbiont to host, apoptotic mitochondrial changes, biological process involved in interaction with symbiont, cellular response to interleukin-7, isotype switching to IgG isotypes, mitochondrial unfolded protein response, negative regulation of apoptotic process, negative regulation of execution phase of apoptosis, positive regulation of T cell activation, positive regulation of T cell mediated immune response to tumor cell, positive regulation of cytokine production, positive regulation of execution phase of apoptosis, positive regulation of interferon-alpha production, positive regulation of interleukin-10 production, positive regulation of interleukin-12 production, positive regulation of interleukin-6 production, positive regulation of macrophage activation, positive regulation of type II interferon production, protein folding, protein import into mitochondrial intermembrane space, protein refolding, protein stabilization, response to cold, response to unfolded protein; MF: ATP binding, ATP-dependent protein folding chaperone, apolipoprotein A-I binding, apolipoprotein binding, cysteine-type endopeptidase activator activity, double-stranded RNA binding, enzyme binding, high-density lipoprotein particle binding, isomerase activity, lipopolysaccharide binding, modification-dependent protein binding, nucleotide binding, p53 binding, protein-containing complex binding, protein-folding chaperone binding, ubiquitin protein ligase binding; CC: Golgi cisterna, cell surface, clathrin-coated pit, coated vesicle, cytoplasm, cytosol, early endosome, extracellular exosome, extracellular space, lipopolysaccharide receptor complex, membrane, migrasome, mitochondrial crista, mitochondrial inner membrane, mitochondrial matrix, mitochondrion, myelin sheath, peroxisomal matrix, plasma membrane, protein-containing complex, secretory granule, sperm midpiece, sperm plasma membrane, zymogen granule
Pathways: Legionellosis - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), Metabolism of proteins, Mitochondrial protein degradation, Mitochondrial protein import, Protein localization, RNA degradation - Mus musculus (mouse), Tuberculosis - Mus musculus (mouse), Type I diabetes mellitus - Mus musculus (mouse)
UniProt: P63038
Entrez ID: 15510
|
Does Knockout of Sdhb in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Sdhb
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Sdhb (succinate dehydrogenase complex, subunit B, iron sulfur (Ip))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: aerobic respiration, mitochondrial electron transport, succinate to ubiquinone, proton motive force-driven mitochondrial ATP synthesis, respiratory electron transport chain, succinate metabolic process, tricarboxylic acid cycle; MF: 2 iron, 2 sulfur cluster binding, 3 iron, 4 sulfur cluster binding, 4 iron, 4 sulfur cluster binding, electron transfer activity, iron-sulfur cluster binding, metal ion binding, oxidoreductase activity, succinate dehydrogenase (quinone) activity, ubiquinone binding; CC: membrane, mitochondrial inner membrane, mitochondrial membrane, mitochondrion, nucleoplasm, plasma membrane, respiratory chain complex II (succinate dehydrogenase)
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Citrate cycle (TCA cycle) - Mus musculus (mouse), Citric acid cycle (TCA cycle), Diabetic cardiomyopathy - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Maturation of TCA enzymes and regulation of TCA cycle, Metabolism, Non-alcoholic fatty liver disease - Mus musculus (mouse), Oxidative phosphorylation - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), TCA cycle, TCA cycle variation III (eukaryotic), Thermogenesis - Mus musculus (mouse), aerobic respiration -- electron donor II, aerobic respiration -- electron donors reaction list
UniProt: Q9CQA3
Entrez ID: 67680
|
Does Knockout of Chrnb2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,271
|
Knockout
|
Chrnb2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Chrnb2 (cholinergic receptor nicotinic beta 2 subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell activation, acetylcholine receptor signaling pathway, associative learning, behavioral response to nicotine, calcium ion transport, central nervous system neuron axonogenesis, central nervous system projection neuron axonogenesis, chemical synaptic transmission, cognition, conditioned taste aversion, establishment of localization in cell, excitatory postsynaptic potential, lateral geniculate nucleus development, learning, locomotory behavior, membrane depolarization, memory, monoatomic ion transmembrane transport, monoatomic ion transport, negative regulation of neuronal action potential, nervous system process, neuronal action potential, optic nerve morphogenesis, positive regulation of B cell proliferation, positive regulation of dopamine secretion, positive regulation of synaptic transmission, dopaminergic, presynaptic modulation of chemical synaptic transmission, regulation of circadian sleep/wake cycle, REM sleep, regulation of circadian sleep/wake cycle, non-REM sleep, regulation of dendrite morphogenesis, regulation of dopamine metabolic process, regulation of dopamine secretion, regulation of membrane potential, regulation of postsynaptic membrane potential, regulation of synapse assembly, regulation of synaptic transmission, dopaminergic, regulation of transmission of nerve impulse, response to acetylcholine, response to cocaine, response to ethanol, response to hypoxia, response to nicotine, sensory perception of pain, sensory perception of sound, signal transduction, smooth muscle contraction, social behavior, synaptic transmission involved in micturition, synaptic transmission, cholinergic, vestibulocochlear nerve development, visual learning, visual perception; MF: acetylcholine binding, acetylcholine receptor activity, acetylcholine-gated monoatomic cation-selective channel activity, extracellular ligand-gated monoatomic ion channel activity, heterocyclic compound binding, monoatomic ion channel activity, protein binding, protein-containing complex binding, quaternary ammonium group binding, transmembrane signaling receptor activity, transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential; CC: acetylcholine-gated channel complex, cation channel complex, cholinergic synapse, dopaminergic synapse, external side of plasma membrane, membrane, neuron projection, neurotransmitter receptor complex, plasma membrane, plasma membrane raft, postsynaptic membrane, postsynaptic specialization membrane, presynaptic membrane, protein-containing complex, synapse, synaptic membrane
Pathways: Acetylcholine binding and downstream events, Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Cholinergic synapse - Mus musculus (mouse), Highly calcium permeable nicotinic acetylcholine receptors, Highly calcium permeable postsynaptic nicotinic acetylcholine receptors, Highly sodium permeable postsynaptic acetylcholine nicotinic receptors, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, Nicotine addiction - Mus musculus (mouse), Postsynaptic nicotinic acetylcholine receptors, Presynaptic nicotinic acetylcholine receptors, Transmission across Chemical Synapses
UniProt: Q9ERK7
Entrez ID: 11444
|
Does Knockout of Cebpz in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 2,307
|
Knockout
|
Cebpz
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Cebpz (CCAAT/enhancer binding protein zeta)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: CCAAT-binding factor complex, nucleoplasm, nucleus
Pathways:
UniProt: P53569
Entrez ID: 12607
|
Does Knockout of Hinfp in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,267
|
Knockout
|
Hinfp
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Hinfp (histone H4 transcription factor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage checkpoint signaling, DNA repair, DNA-templated transcription, G1/S transition of mitotic cell cycle, cell cycle G1/S phase transition, establishment of protein localization, in utero embryonic development, myoblast differentiation, negative regulation of DNA-templated transcription, negative regulation of gene expression, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of gene expression, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, chromatin binding, enzyme binding, histone binding, metal ion binding, transcription cis-regulatory region binding, zinc ion binding; CC: Cajal body, nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: Q8K1K9
Entrez ID: 102423
|
Does Knockout of Cnih4 in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
Cnih4
|
cell cycle progression
|
breast epithelium
|
Gene: Cnih4 (cornichon family AMPA receptor auxiliary protein 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: endoplasmic reticulum to Golgi vesicle-mediated transport, protein transport, vesicle-mediated transport; MF: CCR5 chemokine receptor binding, signaling receptor binding; CC: COPII-coated ER to Golgi transport vesicle, endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum-Golgi intermediate compartment, membrane
Pathways:
UniProt: Q9CX13
Entrez ID: 98417
|
Does Knockout of Sox10 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Sox10
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Sox10 (SRY (sex determining region Y)-box 10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, cell maturation, cellular response to progesterone stimulus, cellular response to xenobiotic stimulus, central nervous system myelination, developmental growth, digestive tract morphogenesis, enteric nervous system development, in utero embryonic development, lacrimal gland development, melanocyte differentiation, morphogenesis of a branching epithelium, morphogenesis of an epithelium, negative regulation of DNA-templated transcription, negative regulation of Schwann cell proliferation, negative regulation of apoptotic process, negative regulation of canonical Wnt signaling pathway, negative regulation of transcription by RNA polymerase II, neural crest cell development, neural crest cell migration, oligodendrocyte development, oligodendrocyte differentiation, peripheral nervous system development, positive regulation of DNA-templated transcription, positive regulation of gene expression, positive regulation of gliogenesis, positive regulation of myelination, positive regulation of neuroblast proliferation, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, stem cell differentiation, transcription elongation by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription factor binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, chromatin binding, identical protein binding, promoter-specific chromatin binding, protein binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding; CC: chromatin, cytoplasm, membrane, mitochondrial outer membrane, mitochondrion, nucleoplasm, nucleus
Pathways: Developmental Biology, MITF-M-regulated melanocyte development, Transcriptional and post-translational regulation of MITF-M expression and activity
UniProt: Q04888
Entrez ID: 20665
|
Does Knockout of Rhpn1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Rhpn1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Rhpn1 (rhophilin, Rho GTPase binding protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: focal adhesion assembly, glomerular filtration, kidney development, negative regulation of stress fiber assembly, plasma membrane bounded cell projection morphogenesis, renal albumin absorption, signal transduction; CC: cell periphery, cytosol, plasma membrane
Pathways: RHO GTPase Effectors, RHO GTPase cycle, RHO GTPases Activate Rhotekin and Rhophilins, RHOA GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q61085
Entrez ID: 14787
|
Does Knockout of Srd5a3 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Srd5a3
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Srd5a3 (steroid 5 alpha-reductase 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: dolichol-linked oligosaccharide biosynthetic process, dolichyl monophosphate biosynthetic process, lipid metabolic process, polyprenol catabolic process, protein glycosylation; MF: 3-oxo-5-alpha-steroid 4-dehydrogenase (NADP+) activity, oxidoreductase activity, oxidoreductase activity, acting on the CH-CH group of donors, oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor, polyprenal reductase activity, polyprenol reductase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Androgen biosynthesis, Asparagine N-linked glycosylation, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, Metabolism, Metabolism of lipids, Metabolism of proteins, Metabolism of steroid hormones, Metabolism of steroids, N-Glycan biosynthesis - Mus musculus (mouse), Post-translational protein modification, Steroid hormone biosynthesis - Mus musculus (mouse), Synthesis of dolichyl-phosphate, Synthesis of substrates in N-glycan biosythesis
UniProt: Q9WUP4
Entrez ID: 57357
|
Does Knockout of Gpr160 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,278
|
Knockout
|
Gpr160
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Gpr160 (G protein-coupled receptor 160)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, signal transduction; CC: membrane, plasma membrane, receptor complex
Pathways:
UniProt: Q3U3F9
Entrez ID: 71862
|
Does Knockout of Ttc39a in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Ttc39a
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Ttc39a (tetratricopeptide repeat domain 39A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: centrosome
Pathways:
UniProt: A2ACP1
Entrez ID: 230603
|
Does Knockout of Nvl in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Nvl
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Nvl (nuclear VCP-like)
Type: protein-coding
Summary: Predicted to enable ATP binding activity; ATP hydrolysis activity; and preribosome binding activity. Predicted to be involved in rRNA processing; regulation of protein localization to nucleolus; and ribosomal large subunit biogenesis. Predicted to be located in nucleoplasm. Predicted to be part of nuclear exosome (RNase complex) and telomerase holoenzyme complex. Predicted to be active in nucleus. Predicted to colocalize with nucleolus. Orthologous to human NVL (nuclear VCP like). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: positive regulation of protein binding, positive regulation of telomere maintenance, rRNA processing, regulation of protein localization to nucleolus, ribosomal large subunit biogenesis, ribosome biogenesis, telomerase holoenzyme complex assembly; MF: ATP binding, ATP hydrolysis activity, nucleotide binding, preribosome binding; CC: nuclear exosome (RNase complex), nucleolus, nucleoplasm, nucleus, telomerase holoenzyme complex
Pathways: Ribosome biogenesis in eukaryotes - Mus musculus (mouse)
UniProt: Q9DBY8
Entrez ID: 67459
|
Does Knockout of Naca in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Naca
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Naca (nascent polypeptide-associated complex alpha polypeptide)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: myoblast migration, negative regulation of protein localization to endoplasmic reticulum, positive regulation of DNA-templated transcription, protein targeting to membrane; MF: DNA binding, TBP-class protein binding, transcription coactivator activity, unfolded protein binding; CC: cytoplasm, nascent polypeptide-associated complex, nucleus
Pathways: Parathyroid hormone synthesis, secretion and action - Mus musculus (mouse)
UniProt: Q60817, P70670
Entrez ID: 17938
|
Does Knockout of Add3 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 82
|
Knockout
|
Add3
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Add3 (adducin 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: barbed-end actin filament capping, cytoskeleton organization, positive regulation of cytoskeleton organization, positive regulation of vasoconstriction, response to xenobiotic stimulus; MF: actin binding, actin filament binding, calmodulin binding, protein kinase C binding, structural constituent of cytoskeleton; CC: brush border, cell cortex, cell-cell junction, condensed nuclear chromosome, cytoplasm, cytoskeleton, membrane, plasma membrane, postsynaptic density
Pathways: Miscellaneous transport and binding events, RHO GTPase cycle, RHOD GTPase cycle, RHOF GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Transport of small molecules
UniProt: Q9QYB5
Entrez ID: 27360
|
Does Knockout of Vmn1r224 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Vmn1r224
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Vmn1r224 (vomeronasal 1 receptor 224)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, biological_process, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled receptor activity, molecular_function, pheromone binding, pheromone receptor activity; CC: cellular_component, membrane, plasma membrane
Pathways:
UniProt: A0A3B2W7L7, E9PWK2, A0A3B2WBL6
Entrez ID: 665525
|
Does Knockout of Mrpl21 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,264
|
Knockout
|
Mrpl21
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Mrpl21 (mitochondrial ribosomal protein L21)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial translation, translation; MF: RNA binding, structural constituent of ribosome; CC: cytoplasm, mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Ribosome - Mus musculus (mouse), Translation
UniProt: Q9D1N9
Entrez ID: 353242
|
Does Knockout of Abcd1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Abcd1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Abcd1 (ATP-binding cassette, sub-family D member 1)
Type: protein-coding
Summary: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. This peroxisomal membrane protein is likely involved in the peroxisomal transport or catabolism of very long chain fatty acids. Defects in the human gene have been identified as the underlying cause of adrenoleukodystrophy, an X-chromosome recessively inherited demyelinating disorder of the nervous system. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: alpha-linolenic acid metabolic process, amide transport, fatty acid beta-oxidation, fatty acid biosynthetic process, fatty acid derivative biosynthetic process, fatty acid elongation, fatty acid homeostasis, fatty-acyl-CoA transport, linoleic acid metabolic process, long-chain fatty acid biosynthetic process, long-chain fatty acid catabolic process, long-chain fatty acid import into peroxisome, myelin maintenance, negative regulation of cytokine production involved in inflammatory response, negative regulation of reactive oxygen species biosynthetic process, neuron projection maintenance, nucleobase-containing compound transport, organophosphate ester transport, peroxisome organization, positive regulation of fatty acid beta-oxidation, positive regulation of unsaturated fatty acid biosynthetic process, regulation of cellular response to oxidative stress, regulation of fatty acid beta-oxidation, regulation of mitochondrial depolarization, regulation of oxidative phosphorylation, sterol homeostasis, transmembrane transport, unsaturated fatty acid biosynthetic process, very long-chain fatty acid catabolic process, very long-chain fatty acid metabolic process, very long-chain fatty-acyl-CoA catabolic process; MF: ABC-type fatty-acyl-CoA transporter activity, ABC-type transporter activity, ADP binding, ATP binding, ATP hydrolysis activity, ATPase-coupled transmembrane transporter activity, amide transmembrane transporter activity, enzyme binding, fatty acyl-CoA hydrolase activity, hydrolase activity, identical protein binding, long-chain fatty acid transmembrane transporter activity, nucleobase-containing compound transmembrane transporter activity, nucleotide binding, organophosphate ester transmembrane transporter activity, protein binding, protein heterodimerization activity, protein homodimerization activity, sulfur compound transmembrane transporter activity, very long-chain fatty acyl-CoA hydrolase activity; CC: cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, lysosomal membrane, lysosome, membrane, mitochondrial membrane, mitochondrion, perinuclear region of cytoplasm, peroxisomal membrane, peroxisome
Pathways: ABC transporters - Mus musculus (mouse), ABC transporters in lipid homeostasis, ABC-family proteins mediated transport, Beta-oxidation of very long chain fatty acids, Class I peroxisomal membrane protein import, Fatty acid metabolism, Linoleic acid (LA) metabolism, Metabolism, Metabolism of lipids, Peroxisomal lipid metabolism, Peroxisome - Mus musculus (mouse), Protein localization, Transport of small molecules, alpha-linolenic (omega3) and linoleic (omega6) acid metabolism, alpha-linolenic acid (ALA) metabolism
UniProt: P48410
Entrez ID: 11666
|
Does Knockout of Snapc2 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Snapc2
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Snapc2 (small nuclear RNA activating complex, polypeptide 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, snRNA transcription, transcription by RNA polymerase II; MF: RNA polymerase II general transcription initiation factor activity, molecular_function; CC: cytosol, nuclear body, nucleoplasm, nucleus
Pathways: Gene expression (Transcription), RNA Polymerase II Transcription, RNA Polymerase III Transcription, RNA Polymerase III Transcription Initiation, RNA Polymerase III Transcription Initiation From Type 3 Promoter, RNA polymerase II transcribes snRNA genes
UniProt: Q91XA5
Entrez ID: 102209
|
Does Knockout of Kat7 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,681
|
Knockout
|
Kat7
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Kat7 (K(lysine) acetyltransferase 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, DNA replication, DNA replication-dependent chromatin disassembly, T cell differentiation, chromatin organization, internal peptidyl-lysine acetylation, natural killer cell differentiation, positive regulation of DNA replication, positive regulation of DNA-templated transcription, elongation, positive regulation of erythrocyte differentiation, positive regulation of hematopoietic stem cell proliferation, positive regulation of nucleobase-containing compound metabolic process, positive regulation of protein localization to nucleus, positive regulation of transcription by RNA polymerase II, regulation of DNA biosynthetic process, regulation of DNA replication, regulation of DNA-templated DNA replication initiation, regulation of DNA-templated transcription, regulation of cell cycle, regulation of cell growth, regulation of nucleotide-excision repair, regulation of transcription by RNA polymerase II, response to actinomycin D, response to anisomycin, response to dithiothreitol, response to hydroxyurea, response to sorbitol, stress-activated protein kinase signaling cascade, transcription initiation-coupled chromatin remodeling; MF: DNA replication origin binding, acyltransferase activity, chromatin binding, histone H3 acetyltransferase activity, histone H3K14 acetyltransferase activity, histone H3K23 acetyltransferase activity, histone H3K4 acetyltransferase activity, histone H4 acetyltransferase activity, histone H4K12 acetyltransferase activity, histone H4K16 acetyltransferase activity, histone H4K5 acetyltransferase activity, histone H4K8 acetyltransferase activity, histone acetyltransferase activity, metal ion binding, protein-lysine-acetyltransferase activity, transcription coregulator activity, transferase activity, zinc ion binding; CC: chromatin, chromosome, chromosome, centromeric region, cytoplasm, cytosol, histone H3-K14 acetyltransferase complex, histone acetyltransferase complex, nucleolus, nucleoplasm, nucleus, site of DNA damage
Pathways: Chromatin modifying enzymes, Chromatin organization, HATs acetylate histones
UniProt: Q5SVQ0
Entrez ID: 217127
|
Does Knockout of Psma6 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,265
|
Knockout
|
Psma6
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Psma6 (proteasome subunit alpha 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of canonical NF-kappaB signal transduction, proteasome-mediated ubiquitin-dependent protein catabolic process, proteolysis involved in protein catabolic process, regulation of inflammatory response, skeletal muscle tissue development, ubiquitin-dependent protein catabolic process; MF: NF-kappaB binding, RNA binding, protein binding; CC: P-body, cilium, cytoplasm, cytosol, mitochondrion, myofibril, nuclear matrix, nucleoplasm, nucleus, proteasome complex, proteasome core complex, proteasome core complex, alpha-subunit complex, ribosome, sarcomere
Pathways: ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, AUF1 (hnRNP D0) binds and destabilizes mRNA, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Activation of NF-kappaB in B cells, Adaptive Immune System, Adherens junctions interactions, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Antigen processing-Cross presentation, Antigen processing: Ub, ATP-independent proteasomal degradation, Antigen processing: Ubiquitination & Proteasome degradation, Assembly of the pre-replicative complex, Asymmetric localization of PCP proteins, Autodegradation of Cdh1 by Cdh1:APC/C, Autodegradation of the E3 ubiquitin ligase COP1, Beta-catenin independent WNT signaling, C-type lectin receptors (CLRs), CDK-mediated phosphorylation and removal of Cdc6, CLEC7A (Dectin-1) signaling, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cellular response to chemical stress, Cellular response to hypoxia, Cellular responses to stimuli, Cellular responses to stress, Circadian clock, Class I MHC mediated antigen processing & presentation, Co-inhibition by PD-1, Cross-presentation of soluble exogenous antigens (endosomes), Cyclin A:Cdk2-associated events at S phase entry, Cyclin E associated events during G1/S transition , Cytokine Signaling in Immune system, DNA Replication, DNA Replication Pre-Initiation, Dectin-1 mediated noncanonical NF-kB signaling, Degradation of AXIN, Degradation of CDH1, Degradation of CRY and PER proteins, Degradation of DVL, Degradation of GLI1 by the proteasome, Degradation of beta-catenin by the destruction complex, Deubiquitination, Downstream TCR signaling, Downstream signaling events of B Cell Receptor (BCR), ER-Phagosome pathway, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, FCERI mediated NF-kB activation, Fc epsilon receptor (FCERI) signaling, G1/S DNA Damage Checkpoints, G1/S Transition, G2/M Checkpoints, G2/M Transition, GLI3 is processed to GLI3R by the proteasome, GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2, GSK3B-mediated proteasomal degradation of PD-L1(CD274), Gene expression (Transcription), Generic Transcription Pathway, Hedgehog 'off' state, Hedgehog 'on' state, Hedgehog ligand biogenesis, Huntington disease - Mus musculus (mouse), Immune System, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, Intracellular signaling by second messengers, KEAP1-NFE2L2 pathway, M Phase, MAPK family signaling cascades, MAPK1/MAPK3 signaling, MAPK6/MAPK4 signaling, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of polyamines, Metabolism of proteins, Mitotic Anaphase, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, NIK-->noncanonical NF-kB signaling, Neddylation, Nuclear events mediated by NFE2L2, Orc1 removal from chromatin, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, PCP/CE pathway, PIP3 activates AKT signaling, PTEN Regulation, Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Post-translational protein modification, Prion disease - Mus musculus (mouse), Proteasome - Mus musculus (mouse), Proteasome assembly, RAF/MAP kinase cascade, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of PTEN stability and activity, Regulation of RAS by GAPs, Regulation of RUNX2 expression and activity, Regulation of RUNX3 expression and activity, Regulation of T cell activation by CD28 family, Regulation of mRNA stability by proteins that bind AU-rich elements, Regulation of mitotic cell cycle, Regulation of ornithine decarboxylase (ODC), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, S Phase, SCF(Skp2)-mediated degradation of p27/p21, SPOP-mediated proteasomal degradation of PD-L1(CD274), Separation of Sister Chromatids, Signal Transduction, Signaling by Hedgehog, Signaling by Interleukins, Signaling by WNT, Signaling by the B Cell Receptor (BCR), Spinocerebellar ataxia - Mus musculus (mouse), Stabilization of p53, Switching of origins to a post-replicative state, Synthesis of DNA, TCF dependent signaling in response to WNT, TCR signaling, TNFR2 non-canonical NF-kB pathway, Targeted protein degradation, The role of GTSE1 in G2/M progression after G2 checkpoint, Transcriptional regulation by RUNX1, Transcriptional regulation by RUNX2, Transcriptional regulation by RUNX3, Translation, Transport of small molecules, UCH proteinases, Ub-specific processing proteases, Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, Ubiquitin-dependent degradation of Cyclin D, p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint, p53-Independent G1/S DNA Damage Checkpoint
UniProt: Q9QUM9
Entrez ID: 26443
|
Does Knockout of Ndufb5 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 2,307
|
Knockout
|
Ndufb5
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Ndufb5 (NADH:ubiquinone oxidoreductase subunit B5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: aerobic respiration, proton motive force-driven mitochondrial ATP synthesis; CC: membrane, mitochondrial inner membrane, mitochondrion, nucleoplasm, respiratory chain complex I
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Complex I biogenesis, Diabetic cardiomyopathy - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Metabolism, NADH to cytochrome <i>bd</i> oxidase electron transfer I, NADH to cytochrome <i>bo</i> oxidase electron transfer I, Non-alcoholic fatty liver disease - Mus musculus (mouse), Oxidative phosphorylation - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Respiratory electron transport, Retrograde endocannabinoid signaling - Mus musculus (mouse), Thermogenesis - Mus musculus (mouse), aerobic respiration -- electron donor II
UniProt: Q9CQH3
Entrez ID: 66046
|
Does Knockout of Nms in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Nms
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Nms (neuromedin S)
Type: protein-coding
Summary: This gene encodes a member of the neuromedin family of neuropeptides. The encoded protein is a precursor that is proteolytically processed to generate a biologically active neuropeptide that plays a role in the regulation of circadian rhythm, anorexigenic action, antidiuretic action, cardiovascular function and stimulation of oxytocin and vasopressin release. Mice lacking the encoded neuropeptide exhibit decreased heart rate without any accompanying changes in blood pressure. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate the mature peptide. [provided by RefSeq, Aug 2015].
Gene Ontology: BP: locomotor rhythm, neuropeptide signaling pathway
Pathways: Class A/1 (Rhodopsin-like receptors), G alpha (i) signalling events, G alpha (q) signalling events, GPCR downstream signalling, GPCR ligand binding, Peptide ligand-binding receptors, Signal Transduction, Signaling by GPCR
UniProt: Q5H8A1
Entrez ID: 433292
|
Does Knockout of Hipk2 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Hipk2
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Hipk2 (homeodomain interacting protein kinase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA damage response, signal transduction by p53 class mediator, SMAD protein signal transduction, adult locomotory behavior, adult walking behavior, anterior/posterior pattern specification, apoptotic process, embryonic camera-type eye morphogenesis, embryonic retina morphogenesis in camera-type eye, gene expression, intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, iris morphogenesis, lens induction in camera-type eye, lung morphogenesis, negative regulation of BMP signaling pathway, negative regulation of neuron apoptotic process, negative regulation of transcription by RNA polymerase II, negative regulation of ubiquitin-dependent protein catabolic process, neuron differentiation, positive regulation of DNA binding, positive regulation of JNK cascade, positive regulation of angiogenesis, positive regulation of cell population proliferation, positive regulation of transcription by RNA polymerase II, positive regulation of transforming growth factor beta receptor signaling pathway, protein phosphorylation, respiratory system process, retina layer formation, smoothened signaling pathway, thyroid gland development, transforming growth factor beta receptor signaling pathway, voluntary musculoskeletal movement; MF: ATP binding, DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, SMAD binding, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, protein tyrosine kinase activity, transcription coactivator activity, transcription corepressor activity, transferase activity, virion binding; CC: PML body, RNA polymerase II transcription regulator complex, cytoplasm, cytoplasmic stress granule, nuclear body, nucleoplasm, nucleus, protein-containing complex
Pathways: Cellular senescence - Mus musculus (mouse), Gene expression (Transcription), Generic Transcription Pathway, Metabolism of proteins, Post-translational protein modification, RNA Polymerase II Transcription, RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known, Regulation of MECP2 expression and activity, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of transcription cofactors, Transcriptional Regulation by MECP2, Transcriptional Regulation by TP53, Transcriptional regulation by RUNX1
UniProt: Q9QZR5
Entrez ID: 15258
|
Does Knockout of Snph in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Snph
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Snph (syntaphilin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of endocytosis, neuron differentiation, vesicle fusion; CC: cytoplasm, cytoplasmic microtubule, membrane, mitochondrial membrane, mitochondrion, neuron projection, neuronal cell body, presynaptic membrane, synapse
Pathways:
UniProt: Q80U23
Entrez ID: 241727
|
Does Knockout of Bhlhe41 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Bhlhe41
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Bhlhe41 (basic helix-loop-helix family, member e41)
Type: protein-coding
Summary: This gene encodes a basic helix-loop-helix protein expressed in various tissues. The encoded protein can interact with Arntl or compete for E-box binding sites in the promoter of Per1 and repress Clock/Arntl's transactivation of Per1. This gene is believed to be involved in the control of circadian rhythm and cell differentiation. Defects in this gene are associated with the short sleep phenotype. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2014].
Gene Ontology: BP: anterior/posterior pattern specification, circadian regulation of gene expression, circadian rhythm, negative regulation of DNA-templated transcription, negative regulation of myotube differentiation, negative regulation of transcription by RNA polymerase II, negative regulation of transcription by competitive promoter binding, regulation of DNA-templated transcription, regulation of neurogenesis, regulation of transcription by RNA polymerase II, rhythmic process; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, E-box binding, MRF binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, bHLH transcription factor binding, histone deacetylase binding, protein binding, protein dimerization activity, protein heterodimerization activity, protein homodimerization activity, sequence-specific double-stranded DNA binding, transcription corepressor activity; CC: nucleoplasm, nucleus, transcription repressor complex
Pathways: Circadian rhythm - Mus musculus (mouse)
UniProt: Q99PV5
Entrez ID: 79362
|
Does Knockout of Rab24 in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Rab24
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Rab24 (RAB24, member RAS oncogene family)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: attachment of spindle microtubules to kinetochore, autophagy, intracellular protein transport, meiotic nuclear division, oocyte maturation, protein transport; MF: G protein activity, GTP binding, GTPase activity, hydrolase activity, metal ion binding, nucleotide binding, protein binding; CC: autophagosome, autophagosome membrane, cytoplasm, cytoplasmic vesicle, cytoskeleton, cytosol, endocytic vesicle, endomembrane system, endosome, membrane, mitochondrion, perinuclear region of cytoplasm, spindle
Pathways: Immune System, Innate Immune System, Metabolism of proteins, Neutrophil degranulation, Post-translational protein modification, RAB geranylgeranylation
UniProt: P35290
Entrez ID: 19336
|
Does Knockout of Pitpnm1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Pitpnm1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Pitpnm1 (phosphatidylinositol transfer protein, membrane-associated 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intermembrane lipid transfer, phospholipid transport, protein transport; MF: calcium ion binding, metal ion binding, phosphatidic acid binding, phosphatidylcholine binding, phosphatidylcholine transporter activity, phosphatidylinositol binding, phosphatidylinositol transfer activity, phospholipid binding, phospholipid transporter activity, receptor tyrosine kinase binding; CC: Golgi apparatus, Golgi cisterna membrane, cell body, cleavage furrow, cytoplasm, cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, lipid droplet, membrane, midbody
Pathways: Glycerophospholipid biosynthesis, Metabolism, Metabolism of lipids, Phospholipid metabolism, Synthesis of PI
UniProt: O35954
Entrez ID: 18739
|
Does Knockout of Mfsd13b in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Mfsd13b
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Mfsd13b (major facilitator superfamily domain containing 13B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, membrane
Pathways:
UniProt: A0A1L1SUA2, Q9D3Y2, F6RDL4, D3YWD7, D3Z0S3
Entrez ID: 74466
|
Does Knockout of Rskr in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
Rskr
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Rskr (ribosomal protein S6 kinase related)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity
Pathways:
UniProt: Q5SYL1
Entrez ID: 216976
|
Does Knockout of Rbm25 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Rbm25
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Rbm25 (RNA binding motif protein 25)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, apoptotic process, mRNA processing, regulation of alternative mRNA splicing, via spliceosome, regulation of apoptotic process; MF: RNA binding, mRNA binding, nucleic acid binding; CC: cytoplasm, nuclear speck, nucleus
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: B2RY56
Entrez ID: 67039
|
Does Knockout of Kmt2d in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Kmt2d
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Kmt2d (lysine (K)-specific methyltransferase 2D)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, developmental growth, heterochromatin formation, in utero embryonic development, methylation, oocyte growth, oogenesis, positive regulation of cell population proliferation, positive regulation of intracellular estrogen receptor signaling pathway, positive regulation of transcription by RNA polymerase II, regulation of gene expression, response to estrogen; MF: DNA-binding transcription activator activity, RNA polymerase II-specific, histone H3K4 methyltransferase activity, histone H3K4 monomethyltransferase activity, histone H3K4 trimethyltransferase activity, metal ion binding, methyltransferase activity, protein binding, transcription cis-regulatory region binding, transcription coactivator activity, transferase activity, zinc ion binding; CC: MLL3/4 complex, histone methyltransferase complex, nucleoplasm, nucleus
Pathways: Cushing syndrome - Mus musculus (mouse), Lysine degradation - Mus musculus (mouse)
UniProt: Q6PDK2
Entrez ID: 381022
|
Does Knockout of Gpx1 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
Gpx1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Gpx1 (glutathione peroxidase 1)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Knockout mice lacking this gene are highly sensitive to oxidants, and develop mature cataracts due to damage to the eye lens nucleus. Other studies indicate that H2O2 is also essential for growth-factor mediated signal transduction, mitochondrial function, and maintenance of thiol redox-balance; therefore, by limiting H2O2 accumulation, glutathione peroxidases are also involved in modulating these processes. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is the most abundant, is ubiquitously expressed and localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. It is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2016].
Gene Ontology: BP: UV protection, angiogenesis involved in wound healing, apoptotic process, arachidonate metabolic process, biological process involved in interaction with symbiont, blood vessel endothelial cell migration, cell redox homeostasis, cellular oxidant detoxification, cellular response to glucose stimulus, cellular response to oxidative stress, endothelial cell development, epigenetic regulation of gene expression, fat cell differentiation, fibroblast proliferation, glutathione metabolic process, heart contraction, hydrogen peroxide catabolic process, intrinsic apoptotic signaling pathway in response to oxidative stress, lipid metabolic process, lipoxygenase pathway, myoblast differentiation, myoblast proliferation, myotube differentiation, negative regulation of extrinsic apoptotic signaling pathway via death domain receptors, negative regulation of inflammatory response to antigenic stimulus, negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway, negative regulation of release of cytochrome c from mitochondria, neuron apoptotic process, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, regulation of mammary gland epithelial cell proliferation, regulation of proteasomal protein catabolic process, response to estradiol, response to folic acid, response to gamma radiation, response to glucose, response to hormone, response to hydrogen peroxide, response to hydroperoxide, response to lipopolysaccharide, response to nicotine, response to oxidative stress, response to reactive oxygen species, response to selenium ion, response to symbiotic bacterium, response to toxic substance, response to vitamin E, response to wounding, response to xenobiotic stimulus, sensory perception of sound, skeletal muscle fiber development, skeletal muscle tissue regeneration, temperature homeostasis, triglyceride metabolic process, vasodilation; MF: SH3 domain binding, glutathione peroxidase activity, oxidoreductase activity, peroxidase activity, phospholipid-hydroperoxide glutathione peroxidase activity, protein binding, protein tyrosine kinase binding; CC: Lewy body, cytoplasm, cytosol, mitochondrion
Pathways: Amyotrophic lateral sclerosis - Mus musculus (mouse), Arachidonate metabolism, Arachidonic acid metabolism - Mus musculus (mouse), Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Detoxification of Reactive Oxygen Species, Fatty acid metabolism, Glutathione metabolism - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Metabolism, Metabolism of lipids, Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Synthesis of 12-eicosatetraenoic acid derivatives, Synthesis of 15-eicosatetraenoic acid derivatives, Thyroid hormone synthesis - Mus musculus (mouse), glutathione redox reactions I
UniProt: P11352
Entrez ID: 14775
|
Does Knockout of Nmbr in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Nmbr
|
phagocytosis
|
macrophage
|
Gene: Nmbr (neuromedin B receptor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, antiviral innate immune response, bombesin receptor signaling pathway, negative regulation of interleukin-6 production, neuropeptide signaling pathway, positive regulation of interferon-alpha production, positive regulation of osteoclast proliferation, positive regulation of respiratory gaseous exchange, signal transduction, sneeze reflex; MF: G protein-coupled peptide receptor activity, G protein-coupled receptor activity, bombesin receptor activity, neuropeptide receptor activity; CC: cytosol, membrane, plasma membrane
Pathways: Class A/1 (Rhodopsin-like receptors), G alpha (q) signalling events, GPCR downstream signalling, GPCR ligand binding, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Peptide ligand-binding receptors, Signal Transduction, Signaling by GPCR
UniProt: O54799
Entrez ID: 18101
|
Does Knockout of Igsf11 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Igsf11
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Igsf11 (immunoglobulin superfamily, member 11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, cell-cell adhesion via plasma-membrane adhesion molecules, homophilic cell adhesion via plasma membrane adhesion molecules, maintenance of protein location, positive regulation of long-term synaptic potentiation, positive regulation of mini excitatory postsynaptic potential, regulation of postsynaptic membrane neurotransmitter receptor levels, regulation of presynapse assembly, regulation of synaptic plasticity, trans-synaptic signaling; MF: ionotropic glutamate receptor binding; CC: cell-cell junction, excitatory synapse, glutamatergic synapse, membrane, plasma membrane, postsynaptic density, postsynaptic density membrane, synapse
Pathways: Cell adhesion molecules - Mus musculus (mouse)
UniProt: P0C673
Entrez ID: 207683
|
Does Knockout of Spdl1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Spdl1
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Spdl1 (spindle apparatus coiled-coil protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, cell migration, establishment of mitotic spindle orientation, mitotic metaphase chromosome alignment, mitotic spindle assembly checkpoint signaling, protein localization to kinetochore; MF: enzyme binding, kinetochore binding; CC: centrosome, chromosome, chromosome, centromeric region, cytoplasm, cytoskeleton, kinetochore, nucleus, outer kinetochore, spindle pole
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, EML4 and NUDC in mitotic spindle formation, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, RHO GTPase Effectors, RHO GTPases Activate Formins, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q923A2
Entrez ID: 70385
|
Does Knockout of Slc44a3 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Slc44a3
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Slc44a3 (solute carrier family 44, member 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: organic cation transport, transmembrane transport; MF: organic cation transmembrane transporter activity, transmembrane transporter activity; CC: membrane
Pathways: Choline metabolism in cancer - Mus musculus (mouse), Glycerophospholipid biosynthesis, Metabolism, Metabolism of lipids, Phospholipid metabolism, SLC-mediated bile acid transport, SLC-mediated transmembrane transport, SLC-mediated transport of organic anions, Synthesis of PC, Transport of small molecules
UniProt: Q921V7
Entrez ID: 213603
|
Does Knockout of Rap1gap2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Rap1gap2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Rap1gap2 (RAP1 GTPase activating protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of neuron projection development, regulation of small GTPase mediated signal transduction; MF: GTPase activator activity; CC: centrosome, cytoplasm, cytosol, neuron projection, nuclear membrane, plasma membrane
Pathways: Adaptive Immune System, Immune System, Rap1 signalling, cyclic AMP biosynthesis
UniProt: Q5SVL6
Entrez ID: 380711
|
Does Knockout of Hscb in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Hscb
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Hscb (HscB iron-sulfur cluster co-chaperone)
Type: protein-coding
Summary: Predicted to enable identical protein binding activity. Involved in primitive erythrocyte differentiation. Located in mitochondrion. Human ortholog(s) of this gene implicated in sideroblastic anemia 5. Orthologous to human HSCB (HscB mitochondrial iron-sulfur cluster cochaperone). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: [2Fe-2S] cluster assembly, erythrocyte differentiation, iron-sulfur cluster assembly, primitive erythrocyte differentiation, primitive hemopoiesis, protein complex oligomerization; MF: ATPase activator activity, identical protein binding, metal ion binding, protein-folding chaperone binding; CC: cytoplasm, cytosol, mitochondrion, nucleoplasm
Pathways: Aerobic respiration and respiratory electron transport, Complex I biogenesis, Complex III assembly, Metabolism, Mitochondrial iron-sulfur cluster biogenesis, Mitochondrial protein import, Protein localization, Respiratory electron transport
UniProt: Q8K3A0
Entrez ID: 100900
|
Does Knockout of Chd8 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Chd8
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Chd8 (chromodomain helicase DNA binding protein 8)
Type: protein-coding
Summary: This gene encodes a member of the chromodomain-helicase-DNA binding protein family, which is characterized by a SNF2-like domain and two chromatin organization modifier domains. The encoded protein also contains brahma and kismet domains, which is common to the subfamily of chromodomain-helicase-DNA binding proteins to which this protein belongs. In mammals, this gene has been shown to function in several processes including transcriptional regulation, epigenetic remodeling, promotion of cell proliferation, and regulation of RNA synthesis. Knockout of this gene causes early embryonic lethality due to widespread apoptosis. Heterozygous loss of function mutations result in autism spectrum disorder-like behaviors that include increased anxiety, repetitive behavior, and altered social behavior. [provided by RefSeq, Dec 2016].
Gene Ontology: BP: Wnt signaling pathway, brain development, chromatin organization, chromatin remodeling, digestive tract development, in utero embryonic development, long-term memory, mRNA processing, negative regulation of DNA-templated transcription, negative regulation of Wnt signaling pathway, negative regulation of apoptotic process, negative regulation of canonical Wnt signaling pathway, negative regulation of fibroblast apoptotic process, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, positive regulation of transcription by RNA polymerase III, prepulse inhibition, regulation of gene expression, social behavior, startle response; MF: ATP binding, ATP hydrolysis activity, ATP-dependent activity, acting on DNA, ATP-dependent chromatin remodeler activity, DNA binding, DNA helicase activity, armadillo repeat domain binding, beta-catenin binding, chromatin binding, histone H3K4me3 reader activity, histone binding, hydrolase activity, nucleotide binding, p53 binding, protein binding; CC: MLL1 complex, chromatin, nucleoplasm, nucleus, protein-containing complex
Pathways: Deactivation of the beta-catenin transactivating complex, Signal Transduction, Signaling by WNT, TCF dependent signaling in response to WNT, Wnt signaling pathway - Mus musculus (mouse)
UniProt: Q09XV5
Entrez ID: 67772
|
Does Knockout of Gadd45g in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Gadd45g
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Gadd45g (growth arrest and DNA-damage-inducible 45 gamma)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T-helper 1 cell differentiation, apoptotic process, cell differentiation, positive regulation of JNK cascade, positive regulation of MAPK cascade, positive regulation of apoptotic process, positive regulation of cold-induced thermogenesis, positive regulation of p38MAPK cascade, regulation of cell cycle; MF: identical protein binding, protein binding; CC: cytoplasm, nucleus
Pathways: Apoptosis - Mus musculus (mouse), Basal cell carcinoma - Mus musculus (mouse), Breast cancer - Mus musculus (mouse), Cell cycle - Mus musculus (mouse), Cellular senescence - Mus musculus (mouse), Chronic myeloid leukemia - Mus musculus (mouse), Colorectal cancer - Mus musculus (mouse), Endometrial cancer - Mus musculus (mouse), Epstein-Barr virus infection - Mus musculus (mouse), FoxO signaling pathway - Mus musculus (mouse), Gastric cancer - Mus musculus (mouse), Glioma - Mus musculus (mouse), Hepatocellular carcinoma - Mus musculus (mouse), MAPK signaling pathway - Mus musculus (mouse), Melanoma - Mus musculus (mouse), NF-kappa B signaling pathway - Mus musculus (mouse), Non-small cell lung cancer - Mus musculus (mouse), Pancreatic cancer - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Small cell lung cancer - Mus musculus (mouse), Thyroid cancer - Mus musculus (mouse), Transcriptional misregulation in cancer - Mus musculus (mouse), p53 signaling pathway - Mus musculus (mouse)
UniProt: Q9R0S0
Entrez ID: 23882
|
Does Knockout of Uckl1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Uckl1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Uckl1 (uridine-cytidine kinase 1-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CMP biosynthetic process, UMP salvage, carbohydrate derivative biosynthetic process, nucleobase-containing compound biosynthetic process, nucleobase-containing small molecule metabolic process, pyrimidine-containing compound salvage; MF: ATP binding, cytidine kinase activity, kinase activity, nucleotide binding, transferase activity, uridine kinase activity; CC: cytoplasm, nucleus
Pathways: Drug metabolism - other enzymes - Mus musculus (mouse), Metabolism, Metabolism of nucleotides, Nucleotide salvage, Pyrimidine metabolism - Mus musculus (mouse), Pyrimidine salvage
UniProt: Q91YL3
Entrez ID: 68556
|
Does Knockout of Gm5885 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Gm5885
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Gm5885 (predicted gene 5885)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID:
|
Does Knockout of Ammecr1l in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Ammecr1l
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Ammecr1l (AMME chromosomal region gene 1-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q8JZZ6
Entrez ID: 225339
|
Does Knockout of Endou in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
Endou
|
cell cycle progression
|
breast epithelium
|
Gene: Endou (endonuclease, polyU-specific)
Type: protein-coding
Summary: Predicted to enable RNA binding activity; RNA endonuclease activity; and serine-type peptidase activity. Predicted to be involved in female pregnancy; negative regulation of metabolic process; and proteolysis. Predicted to be located in cytoplasm. Is expressed in ileum; labyrinthine zone; and metanephros. Orthologous to human ENDOU (endonuclease, poly(U) specific). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: female pregnancy, immune response, negative regulation of lipid catabolic process, post-transcriptional gene silencing, proteolysis, vesicle-mediated transport; MF: RNA binding, RNA endonuclease activity, RNA nuclease activity, endonuclease activity, hydrolase activity, lyase activity, metal ion binding, nuclease activity, polysaccharide binding, scavenger receptor activity, serine-type peptidase activity; CC: cytoplasm, extracellular region
Pathways:
UniProt: Q3V188
Entrez ID: 19011
|
Does Knockout of Vmn2r90 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Vmn2r90
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Vmn2r90 (vomeronasal 2, receptor 90)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, signal transduction; MF: G protein-coupled receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: A0A338P6K0, E9PXJ8, A0A338P772, A0A338P698
Entrez ID: 626942
|
Does Knockout of Maged1 in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Maged1
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Maged1 (MAGE family member D1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: circadian regulation of gene expression, negative regulation of DNA-templated transcription, negative regulation of epithelial cell proliferation, negative regulation of protein localization to nucleus, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of MAP kinase activity, positive regulation of apoptotic signaling pathway, positive regulation of branching involved in ureteric bud morphogenesis, regulation of circadian rhythm, regulation of transcription by RNA polymerase II, rhythmic process; MF: identical protein binding, protein binding, transcription coactivator activity; CC: chromatin, cytoplasm, cytosol, membrane, nucleus, plasma membrane, protein-containing complex
Pathways: Gene expression (Transcription), Generic Transcription Pathway, NPAS4 regulates expression of target genes, Neurotrophin signaling pathway - Mus musculus (mouse), RNA Polymerase II Transcription, Transcriptional Regulation by NPAS4
UniProt: Q9QYH6
Entrez ID: 94275
|
Does Knockout of Cnot10 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
Cnot10
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Cnot10 (CCR4-NOT transcription complex, subunit 10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mRNA catabolic process, negative regulation of translation, regulation of translation, regulatory ncRNA-mediated gene silencing; CC: CCR4-NOT complex, cytoplasm, cytosol, nucleus
Pathways: Deadenylation of mRNA, Deadenylation-dependent mRNA decay, Gene expression (Transcription), Generic Transcription Pathway, Metabolism of RNA, RNA Polymerase II Transcription, RNA degradation - Mus musculus (mouse), TP53 Regulates Transcription of Cell Cycle Genes, TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain, Transcriptional Regulation by TP53
UniProt: Q8BH15
Entrez ID: 78893
|
Does Knockout of Prl6a1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Prl6a1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Prl6a1 (prolactin family 6, subfamily a, member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell surface receptor signaling pathway, female pregnancy, mammary gland development, positive regulation of lactation, positive regulation of receptor signaling pathway via JAK-STAT, response to nutrient levels; MF: hormone activity, prolactin receptor binding; CC: extracellular region, extracellular space
Pathways: Cytokine-cytokine receptor interaction - Mus musculus (mouse), JAK-STAT signaling pathway - Mus musculus (mouse), Neuroactive ligand-receptor interaction - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), Prolactin signaling pathway - Mus musculus (mouse)
UniProt: O35257
Entrez ID: 19111
|
Does Knockout of Tnrc6b in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Tnrc6b
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Tnrc6b (trinucleotide repeat containing 6b)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: miRNA-mediated gene silencing by inhibition of translation, miRNA-mediated post-transcriptional gene silencing, positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay, positive regulation of nuclear-transcribed mRNA poly(A) tail shortening, regulation of translation, regulatory ncRNA-mediated gene silencing; MF: RNA binding, nucleic acid binding; CC: P-body, cytoplasm, cytosol, nucleoplasm
Pathways: Gene Silencing by RNA, Gene expression (Transcription), Post-transcriptional silencing by small RNAs
UniProt: Q8BKI2
Entrez ID: 213988
|
Does Knockout of Xdh in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Xdh
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Xdh (xanthine dehydrogenase)
Type: protein-coding
Summary: This gene encodes a member of the xanthine dehydrogenase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The encoded protein exists as two distinct enzymatic forms, either as xanthine dehydrogenase, or as xanthine oxidase, and functions in purine degradation. Additional studies also suggest a role in adipogenesis, and a function as a structural protein in milk fat droplets in the lactating mammary gland. [provided by RefSeq, Jan 2014].
Gene Ontology: BP: AMP catabolic process, GMP catabolic process, IMP catabolic process, adenosine catabolic process, allantoin metabolic process, amide catabolic process, dAMP catabolic process, dGMP catabolic process, deoxyadenosine catabolic process, deoxyguanosine catabolic process, deoxyinosine catabolic process, guanine catabolic process, hypoxanthine catabolic process, inosine catabolic process, iron-sulfur cluster assembly, lactation, regulation of epithelial cell differentiation, response to aluminum ion, xanthine catabolic process; MF: 2 iron, 2 sulfur cluster binding, FAD binding, flavin adenine dinucleotide binding, hypoxanthine dehydrogenase activity, hypoxanthine oxidase activity, identical protein binding, iron ion binding, iron-sulfur cluster binding, metal ion binding, molybdenum ion binding, molybdopterin cofactor binding, nitrite reductase (NO-forming) activity, oxidoreductase activity, protein binding, protein homodimerization activity, xanthine dehydrogenase activity, xanthine oxidase activity; CC: cytoplasm, cytosol, extracellular region, extracellular space, peroxisome, sarcoplasmic reticulum
Pathways: Adaptive Immune System, Azathioprine ADME, Butyrophilin (BTN) family interactions, Caffeine metabolism - Mus musculus (mouse), Drug ADME, Drug metabolism - other enzymes - Mus musculus (mouse), Immune System, Metabolism, Metabolism of nucleotides, Nucleotide catabolism, Peroxisome - Mus musculus (mouse), Purine catabolism, Purine metabolism - Mus musculus (mouse), adenosine nucleotides degradation II, guanosine nucleotides degradation III, purine nucleotides degradation II (aerobic), urate biosynthesis/inosine 5,-phosphate degradation, ureide biosynthesis
UniProt: Q00519
Entrez ID: 22436
|
Does Knockout of Itgb5 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 1,130
|
Knockout
|
Itgb5
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Itgb5 (integrin beta 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, cell adhesion mediated by integrin, cell migration, cell-cell adhesion, cell-matrix adhesion, epithelial cell-cell adhesion, integrin-mediated signaling pathway, stress fiber assembly, transforming growth factor beta receptor signaling pathway, wound healing, spreading of epidermal cells; MF: integrin binding, metal ion binding, protein binding, signaling receptor binding; CC: cell leading edge, cell surface, focal adhesion, glutamatergic synapse, integrin alphav-beta5 complex, integrin complex, membrane, plasma membrane, receptor complex, synaptic membrane
Pathways: Adaptive Immune System, Antigen processing-Cross presentation, Arrhythmogenic right ventricular cardiomyopathy - Mus musculus (mouse), Class I MHC mediated antigen processing & presentation, Cross-presentation of particulate exogenous antigens (phagosomes), Dilated cardiomyopathy - Mus musculus (mouse), ECM proteoglycans, ECM-receptor interaction - Mus musculus (mouse), Elastic fibre formation, Extracellular matrix organization, Focal adhesion - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Hypertrophic cardiomyopathy - Mus musculus (mouse), Immune System, Integrin cell surface interactions, Molecules associated with elastic fibres, Muscle contraction, Non-integrin membrane-ECM interactions, PI3K-Akt signaling pathway - Mus musculus (mouse), Phagosome - Mus musculus (mouse), Proteoglycans in cancer - Mus musculus (mouse), Regulation of actin cytoskeleton - Mus musculus (mouse), Signal Transduction, Signaling by TGF-beta Receptor Complex, Signaling by TGFB family members, Smooth Muscle Contraction, Syndecan interactions, TGF-beta receptor signaling activates SMADs
UniProt: O70309
Entrez ID: 16419
|
Does Knockout of Ripor3 in Embryonic Fibroblast Cell Line causally result in autophagy?
| 1
| 1,043
|
Knockout
|
Ripor3
|
autophagy
|
Embryonic Fibroblast Cell Line
|
Gene: Ripor3 (RIPOR family member 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: A1L3T7
Entrez ID: 69553
|
Does Knockout of H2-DMb2 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
H2-DMb2
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: H2-DMb2 (histocompatibility 2, class II, locus Mb2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: MHC class II protein complex assembly, adaptive immune response, antigen processing and presentation, antigen processing and presentation of exogenous peptide antigen via MHC class II, antigen processing and presentation of peptide or polysaccharide antigen via MHC class II, immune response, immune system process, peptide antigen assembly with MHC class II protein complex, positive regulation of T cell activation, positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell, positive regulation of T cell proliferation, positive regulation of immune response, protein folding; MF: MHC class II protein complex binding, peptide antigen binding, protein binding; CC: MHC class II protein complex, endosome, endosome membrane, late endosome, late endosome membrane, lysosomal membrane, lysosome, membrane, multivesicular body
Pathways: Adaptive Immune System, Allograft rejection - Mus musculus (mouse), Antigen processing and presentation - Mus musculus (mouse), Asthma - Mus musculus (mouse), Autoimmune thyroid disease - Mus musculus (mouse), Cell adhesion molecules - Mus musculus (mouse), Epstein-Barr virus infection - Mus musculus (mouse), Graft-versus-host disease - Mus musculus (mouse), Hematopoietic cell lineage - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Immune System, Inflammatory bowel disease - Mus musculus (mouse), Influenza A - Mus musculus (mouse), Intestinal immune network for IgA production - Mus musculus (mouse), Leishmaniasis - Mus musculus (mouse), MHC class II antigen presentation, Phagosome - Mus musculus (mouse), Rheumatoid arthritis - Mus musculus (mouse), Staphylococcus aureus infection - Mus musculus (mouse), Systemic lupus erythematosus - Mus musculus (mouse), Th1 and Th2 cell differentiation - Mus musculus (mouse), Th17 cell differentiation - Mus musculus (mouse), Toxoplasmosis - Mus musculus (mouse), Tuberculosis - Mus musculus (mouse), Type I diabetes mellitus - Mus musculus (mouse), Viral myocarditis - Mus musculus (mouse)
UniProt: F7AD18, Q31099
Entrez ID: 15000
|
Does Knockout of Cenpi in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,264
|
Knockout
|
Cenpi
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Cenpi (centromere protein I)
Type: protein-coding
Summary: This gene encodes a protein that may be constitutively associated with centromeres and might be involved in recruiting centromere protein A to the centromere for kinetochore assembly. A similar gene in human is involved in the response of gonadal tissues to follicle-stimulating hormone. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2015].
Gene Ontology: BP: CENP-A containing chromatin assembly, biological_process, centromere complex assembly, chromosome segregation, mitotic sister chromatid segregation; CC: chromosome, chromosome, centromeric region, inner kinetochore, kinetochore, nuclear body, nucleoplasm, nucleus
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Chromosome Maintenance, Deposition of new CENPA-containing nucleosomes at the centromere, EML4 and NUDC in mitotic spindle formation, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, Nucleosome assembly, RHO GTPase Effectors, RHO GTPases Activate Formins, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q8K1K4
Entrez ID: 102920
|
Does Knockout of Tyw3 in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Tyw3
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Tyw3 (tRNA-yW synthesizing protein 3 homolog (S. cerevisiae))
Type: protein-coding
Summary: Predicted to enable tRNA methyltransferase activity. Predicted to be involved in tRNA methylation and wybutosine biosynthetic process. Predicted to be active in cytoplasm. Is expressed in cerebral cortex. Orthologous to human TYW3 (tRNA-yW synthesizing protein 3 homolog). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: methylation, tRNA methylation, tRNA processing, wybutosine biosynthetic process; MF: methyltransferase activity, tRNA methyltransferase activity, transferase activity
Pathways:
UniProt: Q8BSA9
Entrez ID: 209584
|
Does Knockout of Tnrc18 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Tnrc18
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Tnrc18 (trinucleotide repeat containing 18)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein localization to chromatin, transposable element silencing by heterochromatin formation; MF: chromatin binding, chromatin-protein adaptor activity, histone H3K9me2/3 reader activity; CC: chromatin, cytosol, mitochondrion, nuclear membrane, nucleoplasm, nucleus
Pathways:
UniProt: Q80WC3
Entrez ID: 231861
|
Does Knockout of Shoc2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Shoc2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Shoc2 (Shoc2, leucine rich repeat scaffold protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to growth hormone stimulus, cyclic-GMP-AMP transmembrane import across plasma membrane, intracellular signal transduction, negative regulation of neural precursor cell proliferation, negative regulation of neuron differentiation, nerve growth factor signaling pathway, positive regulation of Ras protein signal transduction, positive regulation of neuron differentiation, positive regulation of neuron projection development, regulation of MAPK cascade; MF: protein phosphatase 1 binding, protein phosphatase binding; CC: cytoplasm, cytosol, nucleoplasm, nucleus, protein phosphatase type 1 complex
Pathways: MAPK family signaling cascades, MAPK1/MAPK3 signaling, RAF activation, RAF/MAP kinase cascade, Ras signaling pathway - Mus musculus (mouse), Signal Transduction
UniProt: O88520
Entrez ID: 56392
|
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.