prompt string | hit int64 | screen_id int64 | crispr_strategy string | gene string | phenotype string | cell_type string | gene_context string |
|---|---|---|---|---|---|---|---|
Does Knockout of Atad2b in Lung Cancer Cell Line causally result in tumorigenicity? | 1 | 1,089 | Knockout | Atad2b | tumorigenicity | Lung Cancer Cell Line | Gene: Atad2b (ATPase family, AAA domain containing 2B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: nucleosome assembly, nucleosome disassembly, transcription initiation-coupled chromatin remodeling; MF: ATP binding, ATP hydrolysis activity, chromatin binding, histone ... |
Does Knockout of 4930449I24Rik in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 1 | 82 | Knockout | 4930449I24Rik | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: 4930449I24Rik (RIKEN cDNA 4930449I24 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: guanyl-nucleotide exchange factor activity, molecular_function
Pathways:
UniProt: Q9D5E3
Entrez ID: 67410 |
Does Knockout of Ms4a8a in breast epithelium causally result in cell cycle progression? | 0 | 1,470 | Knockout | Ms4a8a | cell cycle progression | breast epithelium | Gene: Ms4a8a (membrane-spanning 4-domains, subfamily A, member 8A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: membrane, plasma membrane
Pathways:
UniProt: Q99N10
Entrez ID: 64381 |
Does Knockout of Tpr in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,278 | Knockout | Tpr | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: Tpr (translocated promoter region, nuclear basket protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA export from nucleus, RNA import into nucleus, cell division, cellular response to heat, cellular response to interferon-alpha, mRNA export from nucleus, mR... |
Does Knockout of 1700109H08Rik in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,681 | Knockout | 1700109H08Rik | protein/peptide distribution | myoblast cell line | Gene: 1700109H08Rik (RIKEN cDNA 1700109H08 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, regulation of signal transduction; MF: calcium ion binding, metal ion binding, molecular_function
Pathways:
UniProt: D6RH70, Q9D9C0, F6Q... |
Does Knockout of Tnfsf11 in Embryonic Stem Cell Line causally result in cell proliferation? | 0 | 579 | Knockout | Tnfsf11 | cell proliferation | Embryonic Stem Cell Line | Gene: Tnfsf11 (tumor necrosis factor (ligand) superfamily, member 11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: animal organ morphogenesis, bone development, bone resorption, calcium ion homeostasis, calcium-mediated signaling, cell differentiation, cell surface rec... |
Does Knockout of Dhh in myoblast cell line causally result in protein/peptide distribution? | 1 | 1,679 | Knockout | Dhh | protein/peptide distribution | myoblast cell line | Gene: Dhh (desert hedgehog)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Leydig cell differentiation, Schwann cell development, cell fate specification, cell-cell signaling, developmental process involved in reproduction, intein-mediated protein splicing, male gonad de... |
Does Knockout of Esp5 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 0 | 83 | Knockout | Esp5 | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Esp5 (exocrine gland secreted peptide 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 102577427 |
Does Knockout of Ighmbp2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 1 | 83 | Knockout | Ighmbp2 | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Ighmbp2 (immunoglobulin mu DNA binding protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of transcription by RNA polymerase II, neuromuscular process, spinal cord motor neuron differentiation, translation; MF: 5'-3' DNA helicase activity... |
Does Knockout of Pappa in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,278 | Knockout | Pappa | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: Pappa (pregnancy-associated plasma protein A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell surface receptor signaling pathway, protein catabolic process, proteolysis, response to dexamethasone; MF: endopeptidase activity, hydrolase activity, metal ion bindin... |
Does Knockout of Fbxw11 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 1 | 165 | Knockout | Fbxw11 | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Fbxw11 (F-box and WD-40 domain protein 11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, Wnt signaling pathway, brain morphogenesis, establishment of mitotic spindle orientation, germ cell de... |
Does Knockout of Trim12c in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,287 | Knockout | Trim12c | cell proliferation | Mouse kidney carcinoma cell | Gene: Trim12c (tripartite motif-containing 12C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: activation of innate immune response, autophagy, host-mediated suppression of symbiont invasion, innate immune response, positive regulation of MAPK cascade, positive regulatio... |
Does Knockout of Vmn1r15 in Immortal mouse chromaffin cells causally result in cell viability? | 1 | 2,469 | Knockout | Vmn1r15 | cell viability | Immortal mouse chromaffin cells | Gene: Vmn1r15 (vomeronasal 1 receptor 15)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled receptor activity, pheromone ... |
Does Knockout of Nmd3 in Embryonic Stem Cell Line causally result in cell proliferation? | 1 | 579 | Knockout | Nmd3 | cell proliferation | Embryonic Stem Cell Line | Gene: Nmd3 (NMD3 ribosome export adaptor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of RNA biosynthetic process, positive regulation of protein localization to nucleolus, protein transport, ribosomal large subunit export from nucleus; MF: protein... |
Does Knockout of Psmc6 in Embryonic Stem Cell Line causally result in cell proliferation? | 1 | 2,477 | Knockout | Psmc6 | cell proliferation | Embryonic Stem Cell Line | Gene: Psmc6 (proteasome (prosome, macropain) 26S subunit, ATPase, 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ERAD pathway, positive regulation of RNA polymerase II transcription preinitiation complex assembly, positive regulation of inclusion body assembly, protea... |
Does Knockout of Rev1 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,288 | Knockout | Rev1 | cell proliferation | Mouse kidney carcinoma cell | Gene: Rev1 (REV1, DNA directed polymerase)
Type: protein-coding
Summary: Enables deoxycytidyl transferase activity. Acts upstream of or within error-prone translesion synthesis. Predicted to be located in nucleus. Orthologous to human REV1 (REV1 DNA directed polymerase). [provided by Alliance of Genome ... |
Does Knockout of Rbfa in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,681 | Knockout | Rbfa | protein/peptide distribution | myoblast cell line | Gene: Rbfa (ribosome binding factor A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, mitochondrion
Pathways:
UniProt: Q6P3B9
Entrez ID: 68731 |
Does Knockout of Pdcd2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 1 | 82 | Knockout | Pdcd2 | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Pdcd2 (programmed cell death 2)
Type: protein-coding
Summary: Predicted to enable enzyme binding activity. Predicted to be involved in positive regulation of apoptotic process; positive regulation of hematopoietic stem cell proliferation; and regulation of hematopoietic progenitor cell differentia... |
Does Knockout of Prl3a1 in breast epithelium causally result in cell cycle progression? | 0 | 1,468 | Knockout | Prl3a1 | cell cycle progression | breast epithelium | Gene: Prl3a1 (prolactin family 3, subfamily a, member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell surface receptor signaling pathway, female pregnancy, mammary gland development, positive regulation of lactation, positive regulation of receptor signaling pathw... |
Does Knockout of Trim52 in Embryonic Cell Line causally result in protein/peptide accumulation? | 0 | 2,403 | Knockout | Trim52 | protein/peptide accumulation | Embryonic Cell Line | Gene: Trim52 (tripartite motif-containing 52)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: defense response to virus, innate immune response, positive regulation of canonical NF-kappaB signal transduction, protein autoubiquitination, protein ubiquitination; MF: metal i... |
Does Knockout of Btbd35f1 in Embryonic Stem Cell Line causally result in cell proliferation? | 1 | 2,477 | Knockout | Btbd35f1 | cell proliferation | Embryonic Stem Cell Line | Gene: Btbd35f1 (BTB domain containing 35, family member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, cell differentiation, germ cell development, protein ubiquitination, spermatogenesis; CC: nuclear matrix, nucleus
Pathways:
Un... |
Does Knockout of Pold4 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,684 | Knockout | Pold4 | protein/peptide distribution | myoblast cell line | Gene: Pold4 (polymerase (DNA-directed), delta 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, DNA replication, DNA synthesis involved in DNA repair, DNA-templated DNA replication, positive regulation of endothelial cell proliferation; C... |
Does Knockout of Ppp1r1a in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,681 | Knockout | Ppp1r1a | protein/peptide distribution | myoblast cell line | Gene: Ppp1r1a (protein phosphatase 1, regulatory inhibitor subunit 1A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: glycogen metabolic process, intracellular signal transduction, signal transduction; MF: protein binding, protein phosphatase inhibitor activity; CC: cyto... |
Does Knockout of Dapl1 in breast epithelium causally result in cell cycle progression? | 0 | 1,468 | Knockout | Dapl1 | cell cycle progression | breast epithelium | Gene: Dapl1 (death associated protein-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, apoptotic signaling pathway, cell differentiation, cell population proliferation, gene expression, negative regulation of CD8-positive, alpha-beta T cell activ... |
Does Knockout of Taar5 in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,262 | Knockout | Taar5 | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: Taar5 (trace amine-associated receptor 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, adenylate cyclase-activating G protein-coupled receptor signaling pathway, cell surface receptor signaling pathway, cognition, mat... |
Does Knockout of Camk2a in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 1 | 165 | Knockout | Camk2a | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Camk2a (calcium/calmodulin-dependent protein kinase II alpha)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G1/S transition of mitotic cell cycle, angiotensin-activated signaling pathway, calcium ion transport, cell surface receptor signaling pathway via JAK-STAT,... |
Does Knockout of Magoh in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 1 | 83 | Knockout | Magoh | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Magoh (mago homolog, exon junction complex core component)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, female gamete generation, mRNA export from nucleus, mRNA processing, mRNA splicing, via spliceosome, mRNA transport, nuclear-transcribed mRNA cat... |
Does Knockout of Xrcc1 in myoblast cell line causally result in protein/peptide distribution? | 1 | 1,682 | Knockout | Xrcc1 | protein/peptide distribution | myoblast cell line | Gene: Xrcc1 (X-ray repair complementing defective repair in Chinese hamster cells 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, base-excision repair, double-strand break repair, double-strand break repair via nonhomologous end joining... |
Does Knockout of Pdf in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 0 | 81 | Knockout | Pdf | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Pdf (peptide deformylase (mitochondrial))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of cell population proliferation, post-translational protein modification, translation; MF: hydrolase activity, metal ion binding, peptide deformylase activ... |
Does Knockout of Pcsk7 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity? | 0 | 2,172 | Knockout | Pcsk7 | tumorigenicity | Breast Adenocarcinoma Cell Line | Gene: Pcsk7 (proprotein convertase subtilisin/kexin type 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein processing, proteolysis; MF: hydrolase activity, peptidase activity, serine-type endopeptidase activity, serine-type peptidase activity; CC: Golgi apparatus... |
Does Knockout of Urb2 in Microglial Cell Line causally result in protein/peptide distribution? | 1 | 1,585 | Knockout | Urb2 | protein/peptide distribution | Microglial Cell Line | Gene: Urb2 (URB2 ribosome biogenesis 2 homolog (S. cerevisiae))
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: aggresome, midbody, nucleolus
Pathways:
UniProt: G3UX45, E9Q7L1
Entrez ID: 382038 |
Does Knockout of Prkrip1 in Melanoma Cell Line causally result in cell proliferation? | 1 | 1,270 | Knockout | Prkrip1 | cell proliferation | Melanoma Cell Line | Gene: Prkrip1 (Prkr interacting protein 1 (IL11 inducible))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, mRNA processing, renal system process; MF: double-stranded RNA binding, protein binding, protein kinase binding, protein kinase inhibitor activity; CC... |
Does Knockout of Cadps2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 0 | 81 | Knockout | Cadps2 | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Cadps2 (Ca2+-dependent activator protein for secretion 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to starvation, dense core granule exocytosis, exocytosis, hematopoietic stem cell homeostasis, positive regulation of exocytosis, protein tran... |
Does Knockout of Ttll5 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 1 | 82 | Knockout | Ttll5 | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Ttll5 (tubulin tyrosine ligase-like family, member 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: fertilization, flagellated sperm motility, retina development in camera-type eye, sperm axoneme assembly, spermatogenesis; MF: ATP binding, ligase activity, metal i... |
Does Knockout of Lhfpl1 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 1,265 | Knockout | Lhfpl1 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: Lhfpl1 (lipoma HMGIC fusion partner-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: membrane
Pathways:
UniProt: Q80SV1
Entrez ID: 237091 |
Does Knockout of Atat1 in breast epithelium causally result in cell cycle progression? | 0 | 1,470 | Knockout | Atat1 | cell cycle progression | breast epithelium | Gene: Atat1 (alpha tubulin acetyltransferase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: alpha-tubulin acetylation, dentate gyrus development, microtubule cytoskeleton organization, neuron development, positive regulation of NLRP3 inflammasome complex assembly, reg... |
Does Knockout of Rpgrip1 in Regulatory T cell causally result in cell proliferation? | 1 | 2,127 | Knockout | Rpgrip1 | cell proliferation | Regulatory T cell | Gene: Rpgrip1 (retinitis pigmentosa GTPase regulator interacting protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: camera-type eye development, eye photoreceptor cell development, neural precursor cell proliferation, non-motile cilium assembly, retina development... |
Does Knockout of Itfg1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 0 | 1,130 | Knockout | Itfg1 | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Itfg1 (integrin alpha FG-GAP repeat containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: molecular_function, protein binding; CC: extracellular region, membrane, plasma membrane
Pathways:
UniProt: Q99KW9
Entrez ID: 71927 |
Does Knockout of Trim27 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 1 | 82 | Knockout | Trim27 | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Trim27 (tripartite motif-containing 27)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Arp2/3 complex-mediated actin nucleation, innate immune response, negative regulation of autophagy, negative regulation of gene expression, epigenetic, negative regulation of tra... |
Does Knockout of Zxdb in myoblast cell line causally result in protein/peptide distribution? | 1 | 1,681 | Knockout | Zxdb | protein/peptide distribution | myoblast cell line | Gene: Zxdb (zinc finger, X-linked, duplicated B)
Type: protein-coding
Summary: Predicted to enable C2H2 zinc finger domain binding activity and transcription coactivator activity. Predicted to be involved in positive regulation of DNA-templated transcription and regulation of transcription by RNA polyme... |
Does Knockout of Gchfr in Microglial Cell Line causally result in response to virus? | 0 | 2,429 | Knockout | Gchfr | response to virus | Microglial Cell Line | Gene: Gchfr (GTP cyclohydrolase I feedback regulator)
Type: protein-coding
Summary: Enables GTP cyclohydrolase I regulator activity and enzyme inhibitor activity. Involved in negative regulation of small molecule metabolic process. Predicted to be located in dendrite; melanosome; and nucleus. Predicted ... |
Does Knockout of Rab6a in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 1 | 83 | Knockout | Rab6a | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Rab6a (RAB6A, member RAS oncogene family)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: antigen processing and presentation, early endosome to Golgi transport, intra-Golgi vesicle-mediated transport, intracellular protein transport, protein localization to Golgi a... |
Does Knockout of Pcp4l1 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,271 | Knockout | Pcp4l1 | cell proliferation | Mouse kidney carcinoma cell | Gene: Pcp4l1 (Purkinje cell protein 4-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q6W8Q3
Entrez ID: 66425 |
Does Knockout of Hspd1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 1,262 | Knockout | Hspd1 | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: Hspd1 (heat shock protein 1 (chaperonin))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell activation, B cell proliferation, MyD88-dependent toll-like receptor signaling pathway, T cell activation, adhesion of symbiont to host, apoptotic mitochondrial changes,... |
Does Knockout of Sdhb in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,280 | Knockout | Sdhb | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: Sdhb (succinate dehydrogenase complex, subunit B, iron sulfur (Ip))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: aerobic respiration, mitochondrial electron transport, succinate to ubiquinone, proton motive force-driven mitochondrial ATP synthesis, respiratory el... |
Does Knockout of Chrnb2 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,271 | Knockout | Chrnb2 | cell proliferation | Mouse kidney carcinoma cell | Gene: Chrnb2 (cholinergic receptor nicotinic beta 2 subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell activation, acetylcholine receptor signaling pathway, associative learning, behavioral response to nicotine, calcium ion transport, central nervous system n... |
Does Knockout of Cebpz in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals? | 1 | 2,307 | Knockout | Cebpz | response to chemicals | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: Cebpz (CCAAT/enhancer binding protein zeta)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: CCAAT-binding factor complex, nucleoplasm, nucleus
Pathways:
UniProt: P53569
Entrez ID: 12607 |
Does Knockout of Hinfp in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 1,267 | Knockout | Hinfp | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: Hinfp (histone H4 transcription factor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage checkpoint signaling, DNA repair, DNA-templated transcription, G1/S transition of mitotic cell cycle, cell cycle G1/S phase transition, establishment of protein locali... |
Does Knockout of Cnih4 in breast epithelium causally result in cell cycle progression? | 0 | 1,468 | Knockout | Cnih4 | cell cycle progression | breast epithelium | Gene: Cnih4 (cornichon family AMPA receptor auxiliary protein 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: endoplasmic reticulum to Golgi vesicle-mediated transport, protein transport, vesicle-mediated transport; MF: CCR5 chemokine receptor binding, signaling recept... |
Does Knockout of Sox10 in Embryonic Stem Cell Line causally result in cell proliferation? | 1 | 2,477 | Knockout | Sox10 | cell proliferation | Embryonic Stem Cell Line | Gene: Sox10 (SRY (sex determining region Y)-box 10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, cell maturation, cellular response to progesterone stimulus, cellular response to xenobiotic stimulus, central nervous system myelination, development... |
Does Knockout of Rhpn1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 1 | 81 | Knockout | Rhpn1 | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Rhpn1 (rhophilin, Rho GTPase binding protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: focal adhesion assembly, glomerular filtration, kidney development, negative regulation of stress fiber assembly, plasma membrane bounded cell projection morphogenesis, r... |
Does Knockout of Srd5a3 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 1 | 165 | Knockout | Srd5a3 | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Srd5a3 (steroid 5 alpha-reductase 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: dolichol-linked oligosaccharide biosynthetic process, dolichyl monophosphate biosynthetic process, lipid metabolic process, polyprenol catabolic process, protein glycosylation; MF: ... |
Does Knockout of Gpr160 in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 1,278 | Knockout | Gpr160 | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: Gpr160 (G protein-coupled receptor 160)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, signal transduction; CC: membrane, plasma membrane, receptor complex
Pathways:
UniProt: Q3U3F9
Entrez ID:... |
Does Knockout of Ttc39a in Immortal mouse chromaffin cells causally result in cell viability? | 1 | 2,469 | Knockout | Ttc39a | cell viability | Immortal mouse chromaffin cells | Gene: Ttc39a (tetratricopeptide repeat domain 39A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: centrosome
Pathways:
UniProt: A2ACP1
Entrez ID: 230603 |
Does Knockout of Nvl in Embryonic Stem Cell Line causally result in cell proliferation? | 1 | 2,477 | Knockout | Nvl | cell proliferation | Embryonic Stem Cell Line | Gene: Nvl (nuclear VCP-like)
Type: protein-coding
Summary: Predicted to enable ATP binding activity; ATP hydrolysis activity; and preribosome binding activity. Predicted to be involved in rRNA processing; regulation of protein localization to nucleolus; and ribosomal large subunit biogenesis. Predicted ... |
Does Knockout of Naca in Embryonic Stem Cell Line causally result in cell proliferation? | 1 | 2,477 | Knockout | Naca | cell proliferation | Embryonic Stem Cell Line | Gene: Naca (nascent polypeptide-associated complex alpha polypeptide)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: myoblast migration, negative regulation of protein localization to endoplasmic reticulum, positive regulation of DNA-templated transcription, protein targ... |
Does Knockout of Add3 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 0 | 82 | Knockout | Add3 | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Add3 (adducin 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: barbed-end actin filament capping, cytoskeleton organization, positive regulation of cytoskeleton organization, positive regulation of vasoconstriction, response to xenobiotic stimulus; MF: actin bindi... |
Does Knockout of Vmn1r224 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,267 | Knockout | Vmn1r224 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: Vmn1r224 (vomeronasal 1 receptor 224)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, biological_process, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled recepto... |
Does Knockout of Mrpl21 in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 1,264 | Knockout | Mrpl21 | cell proliferation | Colonic Cancer Cell Line | Gene: Mrpl21 (mitochondrial ribosomal protein L21)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial translation, translation; MF: RNA binding, structural constituent of ribosome; CC: cytoplasm, mitochondrial inner membrane, mitochondrial large ribosomal subun... |
Does Knockout of Abcd1 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,287 | Knockout | Abcd1 | cell proliferation | Mouse kidney carcinoma cell | Gene: Abcd1 (ATP-binding cassette, sub-family D member 1)
Type: protein-coding
Summary: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC... |
Does Knockout of Snapc2 in Embryonic Stem Cell Line causally result in cell proliferation? | 1 | 2,477 | Knockout | Snapc2 | cell proliferation | Embryonic Stem Cell Line | Gene: Snapc2 (small nuclear RNA activating complex, polypeptide 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, snRNA transcription, transcription by RNA polymerase II; MF: RNA polymerase II general transcription initiation factor activity, molecula... |
Does Knockout of Kat7 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,681 | Knockout | Kat7 | protein/peptide distribution | myoblast cell line | Gene: Kat7 (K(lysine) acetyltransferase 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, DNA replication, DNA replication-dependent chromatin disassembly, T cell differentiation, chromatin organization, internal peptidyl-lysine acetylati... |
Does Knockout of Psma6 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 1 | 1,265 | Knockout | Psma6 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: Psma6 (proteasome subunit alpha 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of canonical NF-kappaB signal transduction, proteasome-mediated ubiquitin-dependent protein catabolic process, proteolysis involved in protein catabolic process, r... |
Does Knockout of Ndufb5 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals? | 1 | 2,307 | Knockout | Ndufb5 | response to chemicals | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: Ndufb5 (NADH:ubiquinone oxidoreductase subunit B5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: aerobic respiration, proton motive force-driven mitochondrial ATP synthesis; CC: membrane, mitochondrial inner membrane, mitochondrion, nucleoplasm, respiratory chain ... |
Does Knockout of Nms in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,264 | Knockout | Nms | cell proliferation | Colonic Cancer Cell Line | Gene: Nms (neuromedin S)
Type: protein-coding
Summary: This gene encodes a member of the neuromedin family of neuropeptides. The encoded protein is a precursor that is proteolytically processed to generate a biologically active neuropeptide that plays a role in the regulation of circadian rhythm, anorex... |
Does Knockout of Hipk2 in Embryonic Stem Cell Line causally result in cell proliferation? | 0 | 578 | Knockout | Hipk2 | cell proliferation | Embryonic Stem Cell Line | Gene: Hipk2 (homeodomain interacting protein kinase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA damage response, signal transduction by p53 class mediator, SMAD protein signal transduction, adult locomotory behavior, adult walking behavior,... |
Does Knockout of Snph in Regulatory T cell causally result in protein/peptide accumulation? | 0 | 1,482 | Knockout | Snph | protein/peptide accumulation | Regulatory T cell | Gene: Snph (syntaphilin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of endocytosis, neuron differentiation, vesicle fusion; CC: cytoplasm, cytoplasmic microtubule, membrane, mitochondrial membrane, mitochondrion, neuron projection, neuronal cell b... |
Does Knockout of Bhlhe41 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,286 | Knockout | Bhlhe41 | cell proliferation | Mouse kidney carcinoma cell | Gene: Bhlhe41 (basic helix-loop-helix family, member e41)
Type: protein-coding
Summary: This gene encodes a basic helix-loop-helix protein expressed in various tissues. The encoded protein can interact with Arntl or compete for E-box binding sites in the promoter of Per1 and repress Clock/Arntl's transa... |
Does Knockout of Rab24 in Mouse cell causally result in protein/peptide accumulation? | 0 | 1,047 | Knockout | Rab24 | protein/peptide accumulation | Mouse cell | Gene: Rab24 (RAB24, member RAS oncogene family)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: attachment of spindle microtubules to kinetochore, autophagy, intracellular protein transport, meiotic nuclear division, oocyte maturation, protein transport; MF: G protein act... |
Does Knockout of Pitpnm1 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,290 | Knockout | Pitpnm1 | cell proliferation | Mouse kidney carcinoma cell | Gene: Pitpnm1 (phosphatidylinositol transfer protein, membrane-associated 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intermembrane lipid transfer, phospholipid transport, protein transport; MF: calcium ion binding, metal ion binding, phosphatidic acid binding, pho... |
Does Knockout of Mfsd13b in Embryonic Stem Cell Line causally result in cell proliferation? | 0 | 578 | Knockout | Mfsd13b | cell proliferation | Embryonic Stem Cell Line | Gene: Mfsd13b (major facilitator superfamily domain containing 13B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, membrane
Pathways:
UniProt: A0A1L1SUA2, Q9D3Y2, F6RDL4, D3YWD7, D3Z0S3
Entrez ID: 74466 |
Does Knockout of Rskr in Melanoma Cell Line causally result in cell proliferation? | 0 | 2,492 | Knockout | Rskr | cell proliferation | Melanoma Cell Line | Gene: Rskr (ribosomal protein S6 kinase related)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity
... |
Does Knockout of Rbm25 in myoblast cell line causally result in protein/peptide distribution? | 1 | 1,679 | Knockout | Rbm25 | protein/peptide distribution | myoblast cell line | Gene: Rbm25 (RNA binding motif protein 25)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, apoptotic process, mRNA processing, regulation of alternative mRNA splicing, via spliceosome, regulation of apoptotic process; MF: RNA binding, mRNA binding, nucleic a... |
Does Knockout of Kmt2d in myoblast cell line causally result in protein/peptide distribution? | 1 | 1,682 | Knockout | Kmt2d | protein/peptide distribution | myoblast cell line | Gene: Kmt2d (lysine (K)-specific methyltransferase 2D)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, developmental growth, heterochromatin formation, in utero embryonic development, methylation, oocyte growth, oogenesis, positive regulation of ce... |
Does Knockout of Gpx1 in Melanoma Cell Line causally result in cell proliferation? | 0 | 2,492 | Knockout | Gpx1 | cell proliferation | Melanoma Cell Line | Gene: Gpx1 (glutathione peroxidase 1)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative da... |
Does Knockout of Nmbr in macrophage causally result in phagocytosis? | 0 | 1,888 | Knockout | Nmbr | phagocytosis | macrophage | Gene: Nmbr (neuromedin B receptor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, antiviral innate immune response, bombesin receptor signaling pathway, negative regulation of interleukin-6 production, neuropeptide signaling ... |
Does Knockout of Igsf11 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,275 | Knockout | Igsf11 | cell proliferation | Colonic Cancer Cell Line | Gene: Igsf11 (immunoglobulin superfamily, member 11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, cell-cell adhesion via plasma-membrane adhesion molecules, homophilic cell adhesion via plasma membrane adhesion molecules, maintenance of protein location,... |
Does Knockout of Spdl1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 2,307 | Knockout | Spdl1 | response to chemicals | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: Spdl1 (spindle apparatus coiled-coil protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, cell migration, establishment of mitotic spindle orientation, mitotic metaphase chromosome alignment, mitotic spindle assembly checkpoint signaling, protei... |
Does Knockout of Slc44a3 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 1 | 165 | Knockout | Slc44a3 | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Slc44a3 (solute carrier family 44, member 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: organic cation transport, transmembrane transport; MF: organic cation transmembrane transporter activity, transmembrane transporter activity; CC: membrane
Pathways:... |
Does Knockout of Rap1gap2 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,288 | Knockout | Rap1gap2 | cell proliferation | Mouse kidney carcinoma cell | Gene: Rap1gap2 (RAP1 GTPase activating protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of neuron projection development, regulation of small GTPase mediated signal transduction; MF: GTPase activator activity; CC: centrosome, cytoplasm, cytos... |
Does Knockout of Hscb in Pancreatic Cancer Cell Line causally result in response to chemicals? | 0 | 2,359 | Knockout | Hscb | response to chemicals | Pancreatic Cancer Cell Line | Gene: Hscb (HscB iron-sulfur cluster co-chaperone)
Type: protein-coding
Summary: Predicted to enable identical protein binding activity. Involved in primitive erythrocyte differentiation. Located in mitochondrion. Human ortholog(s) of this gene implicated in sideroblastic anemia 5. Orthologous to human ... |
Does Knockout of Chd8 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,275 | Knockout | Chd8 | cell proliferation | Colonic Cancer Cell Line | Gene: Chd8 (chromodomain helicase DNA binding protein 8)
Type: protein-coding
Summary: This gene encodes a member of the chromodomain-helicase-DNA binding protein family, which is characterized by a SNF2-like domain and two chromatin organization modifier domains. The encoded protein also contains brahm... |
Does Knockout of Gadd45g in myoblast cell line causally result in protein/peptide distribution? | 1 | 1,681 | Knockout | Gadd45g | protein/peptide distribution | myoblast cell line | Gene: Gadd45g (growth arrest and DNA-damage-inducible 45 gamma)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T-helper 1 cell differentiation, apoptotic process, cell differentiation, positive regulation of JNK cascade, positive regulation of MAPK cascade, positive regu... |
Does Knockout of Uckl1 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,264 | Knockout | Uckl1 | cell proliferation | Colonic Cancer Cell Line | Gene: Uckl1 (uridine-cytidine kinase 1-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CMP biosynthetic process, UMP salvage, carbohydrate derivative biosynthetic process, nucleobase-containing compound biosynthetic process, nucleobase-containing small molecule me... |
Does Knockout of Gm5885 in Embryonic Fibroblast Cell Line causally result in response to virus? | 0 | 1,133 | Knockout | Gm5885 | response to virus | Embryonic Fibroblast Cell Line | Gene: Gm5885 (predicted gene 5885)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: |
Does Knockout of Ammecr1l in myoblast cell line causally result in protein/peptide distribution? | 1 | 1,681 | Knockout | Ammecr1l | protein/peptide distribution | myoblast cell line | Gene: Ammecr1l (AMME chromosomal region gene 1-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q8JZZ6
Entrez ID: 225339 |
Does Knockout of Endou in breast epithelium causally result in cell cycle progression? | 0 | 1,468 | Knockout | Endou | cell cycle progression | breast epithelium | Gene: Endou (endonuclease, polyU-specific)
Type: protein-coding
Summary: Predicted to enable RNA binding activity; RNA endonuclease activity; and serine-type peptidase activity. Predicted to be involved in female pregnancy; negative regulation of metabolic process; and proteolysis. Predicted to be locat... |
Does Knockout of Vmn2r90 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,290 | Knockout | Vmn2r90 | cell proliferation | Mouse kidney carcinoma cell | Gene: Vmn2r90 (vomeronasal 2, receptor 90)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, signal transduction; MF: G protein-coupled receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: A0A33... |
Does Knockout of Maged1 in Mouse cell causally result in protein/peptide accumulation? | 0 | 1,047 | Knockout | Maged1 | protein/peptide accumulation | Mouse cell | Gene: Maged1 (MAGE family member D1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: circadian regulation of gene expression, negative regulation of DNA-templated transcription, negative regulation of epithelial cell proliferation, negative regulation of protein localizat... |
Does Knockout of Cnot10 in Melanoma Cell Line causally result in cell proliferation? | 0 | 2,492 | Knockout | Cnot10 | cell proliferation | Melanoma Cell Line | Gene: Cnot10 (CCR4-NOT transcription complex, subunit 10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mRNA catabolic process, negative regulation of translation, regulation of translation, regulatory ncRNA-mediated gene silencing; CC: CCR4-NOT complex, cytoplasm, cyto... |
Does Knockout of Prl6a1 in myoblast cell line causally result in protein/peptide distribution? | 1 | 1,679 | Knockout | Prl6a1 | protein/peptide distribution | myoblast cell line | Gene: Prl6a1 (prolactin family 6, subfamily a, member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell surface receptor signaling pathway, female pregnancy, mammary gland development, positive regulation of lactation, positive regulation of receptor signaling pathw... |
Does Knockout of Tnrc6b in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 1,265 | Knockout | Tnrc6b | cell proliferation | Mammary Gland Tumor Cell Line | Gene: Tnrc6b (trinucleotide repeat containing 6b)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: miRNA-mediated gene silencing by inhibition of translation, miRNA-mediated post-transcriptional gene silencing, positive regulation of nuclear-transcribed mRNA catabolic proc... |
Does Knockout of Xdh in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,287 | Knockout | Xdh | cell proliferation | Mouse kidney carcinoma cell | Gene: Xdh (xanthine dehydrogenase)
Type: protein-coding
Summary: This gene encodes a member of the xanthine dehydrogenase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The encoded protein exists as tw... |
Does Knockout of Itgb5 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 1 | 1,130 | Knockout | Itgb5 | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Itgb5 (integrin beta 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, cell adhesion mediated by integrin, cell migration, cell-cell adhesion, cell-matrix adhesion, epithelial cell-cell adhesion, integrin-mediated signaling pathway, stress fiber asse... |
Does Knockout of Ripor3 in Embryonic Fibroblast Cell Line causally result in autophagy? | 1 | 1,043 | Knockout | Ripor3 | autophagy | Embryonic Fibroblast Cell Line | Gene: Ripor3 (RIPOR family member 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: A1L3T7
Entrez ID: 69553 |
Does Knockout of H2-DMb2 in Embryonic Stem Cell Line causally result in cell proliferation? | 0 | 579 | Knockout | H2-DMb2 | cell proliferation | Embryonic Stem Cell Line | Gene: H2-DMb2 (histocompatibility 2, class II, locus Mb2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: MHC class II protein complex assembly, adaptive immune response, antigen processing and presentation, antigen processing and presentation of exogenous peptide antigen... |
Does Knockout of Cenpi in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 1,264 | Knockout | Cenpi | cell proliferation | Colonic Cancer Cell Line | Gene: Cenpi (centromere protein I)
Type: protein-coding
Summary: This gene encodes a protein that may be constitutively associated with centromeres and might be involved in recruiting centromere protein A to the centromere for kinetochore assembly. A similar gene in human is involved in the response of ... |
Does Knockout of Tyw3 in Immortal mouse chromaffin cells causally result in cell viability? | 1 | 2,469 | Knockout | Tyw3 | cell viability | Immortal mouse chromaffin cells | Gene: Tyw3 (tRNA-yW synthesizing protein 3 homolog (S. cerevisiae))
Type: protein-coding
Summary: Predicted to enable tRNA methyltransferase activity. Predicted to be involved in tRNA methylation and wybutosine biosynthetic process. Predicted to be active in cytoplasm. Is expressed in cerebral cortex. O... |
Does Knockout of Tnrc18 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 1 | 165 | Knockout | Tnrc18 | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Tnrc18 (trinucleotide repeat containing 18)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein localization to chromatin, transposable element silencing by heterochromatin formation; MF: chromatin binding, chromatin-protein adaptor activity, histone H3K9me2/3 r... |
Does Knockout of Shoc2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 1 | 82 | Knockout | Shoc2 | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Shoc2 (Shoc2, leucine rich repeat scaffold protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to growth hormone stimulus, cyclic-GMP-AMP transmembrane import across plasma membrane, intracellular signal transduction, negative regulation of ne... |
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