prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Pcmtd1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
Pcmtd1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Pcmtd1 (protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein ubiquitination; MF: S-adenosylmethionine-dependent methyltransferase activity, protein-L-isoaspartate (D-aspartate) O-methyltransferase activity, ubiquitin-like ligase-substrate adaptor activity; CC: Cul5-RING ubiquitin ligase complex, cytoplasm, membrane
Pathways:
UniProt: P59913
Entrez ID: 319263
|
Does Knockout of Zfp940 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Zfp940
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Zfp940 (zinc finger protein 940)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Mus musculus (mouse), RNA Polymerase II Transcription
UniProt: Q8R2Q3, Q3UVK2
Entrez ID: 233057
|
Does Knockout of Hcn3 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Hcn3
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Hcn3 (hyperpolarization-activated, cyclic nucleotide-gated K+ 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to cAMP, monoatomic ion transmembrane transport, monoatomic ion transport, potassium ion transmembrane transport, potassium ion transport, regulation of membrane depolarization, regulation of membrane potential, sodium ion transmembrane transport, sodium ion transport, transmembrane transport; MF: cAMP binding, intracellularly cAMP-activated cation channel activity, monoatomic ion channel activity, nucleotide binding, potassium channel activity, protein binding, sodium channel activity, voltage-gated potassium channel activity, voltage-gated sodium channel activity; CC: HCN channel complex, axon, cone cell pedicle, dendrite, membrane, monoatomic ion channel complex, neuronal cell body, plasma membrane
Pathways: GnRH secretion - Mus musculus (mouse), HCN channels, Neuronal System, Potassium Channels
UniProt: O88705
Entrez ID: 15168
|
Does Knockout of Gm9869 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,279
|
Knockout
|
Gm9869
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Gm9869 (predicted gene 9869)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID:
|
Does Knockout of Usp20 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Usp20
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Usp20 (ubiquitin specific peptidase 20)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: antiviral innate immune response, canonical NF-kappaB signal transduction, endocytosis, negative regulation of canonical NF-kappaB signal transduction, nervous system development, positive regulation of autophagy, protein K48-linked deubiquitination, protein K63-linked deubiquitination, protein deubiquitination, proteolysis, regulation of G protein-coupled receptor signaling pathway; MF: G protein-coupled receptor binding, cysteine-type deubiquitinase activity, cysteine-type endopeptidase activity, cysteine-type peptidase activity, hydrolase activity, metal ion binding, peptidase activity, zinc ion binding; CC: centrosome, cytoplasm, cytoskeleton, endoplasmic reticulum, perinuclear region of cytoplasm
Pathways: Deubiquitination, Metabolism of proteins, Post-translational protein modification, Ub-specific processing proteases
UniProt: Q8C6M1
Entrez ID: 74270
|
Does Knockout of Cldn12 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Cldn12
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Cldn12 (claudin 12)
Type: protein-coding
Summary: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene, along with several other family members, is expressed in the inner ear. The protein encoded by this gene and another family member, claudin 2, are critical for vitamin D-dependent Ca2+ absorption between enterocytes. Multiple alternatively spliced transcript variants encoding the same protein have been found. [provided by RefSeq, Oct 2011].
Gene Ontology: BP: calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules, tight junction assembly; CC: anchoring junction, bicellular tight junction, cell periphery, lateral plasma membrane, membrane, plasma membrane, tight junction
Pathways:
UniProt: Q9ET43
Entrez ID: 64945
|
Does Knockout of Wdsub1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Wdsub1
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Wdsub1 (WD repeat, SAM and U-box domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, protein ubiquitination; MF: molecular_function, ubiquitin-protein transferase activity
Pathways:
UniProt: Q9D0I6
Entrez ID: 72137
|
Does Knockout of Adarb2 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 161
|
Knockout
|
Adarb2
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Adarb2 (adenosine deaminase, RNA-specific, B2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 3'-UTR-mediated mRNA stabilization, RNA processing, adenosine to inosine editing, mRNA processing; MF: RNA binding, adenosine deaminase activity, double-stranded RNA adenosine deaminase activity, double-stranded RNA binding, hydrolase activity, mRNA binding, metal ion binding, tRNA-specific adenosine deaminase activity; CC: cytoplasm, nucleolus, nucleus
Pathways:
UniProt: Q9JI20
Entrez ID: 94191
|
Does Knockout of Prrg3 in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Prrg3
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Prrg3 (proline rich Gla (G-carboxyglutamic acid) 3 (transmembrane))
Type: protein-coding
Summary: This gene encodes proline-rich gamma-carboxyglutamic acid protein 3, a member of vitamin K-dependent membrane proteins containing gamma-carboxyglutamic acid residues. The encoded precursor protein contains an N-terminal propeptide that is required for the carboxylation of glutamate residues in the mature protein. Alternate splicing of this gene results in multiple transcript variants that encode the same protein. [provided by RefSeq, Dec 2014].
Gene Ontology: BP: biological_process, blood coagulation, proteolysis; MF: calcium ion binding, molecular_function, serine-type endopeptidase activity; CC: extracellular region, extracellular space, membrane
Pathways:
UniProt: Q6PAQ9
Entrez ID: 208748
|
Does Knockout of Larp1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
Larp1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Larp1 (La ribonucleoprotein 1, translational regulator)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: TOR signaling, TORC1 signaling, cell population proliferation, cellular response to rapamycin, mRNA stabilization, negative regulation of translation, negative regulation of translational initiation, positive regulation of macroautophagy, positive regulation of translation, positive regulation of translational initiation, positive regulation of viral genome replication, post-transcriptional regulation of gene expression, regulation of translation, response to amino acid starvation, translational initiation; MF: RNA 7-methylguanosine cap binding, RNA binding, RNA cap binding, eukaryotic initiation factor 4E binding, mRNA 3'-UTR binding, mRNA 5'-UTR binding, ribosomal small subunit binding, translation activator activity, translation initiation factor binding; CC: TORC1 complex, cytoplasm, cytoplasmic stress granule, cytosol
Pathways:
UniProt: Q6ZQ58
Entrez ID: 73158
|
Does Knockout of Det1 in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Det1
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Det1 (DET1 partner of COP1 E3 ubiquitin ligase)
Type: protein-coding
Summary: Predicted to enable ubiquitin protein ligase binding activity and ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination; and protein-containing complex assembly. Predicted to be part of Cul4A-RING E3 ubiquitin ligase complex. Predicted to be active in nucleus. Orthologous to human DET1 (DET1 partner of COP1 E3 ubiquitin ligase). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: positive regulation of proteasomal ubiquitin-dependent protein catabolic process, protein ubiquitination, protein-containing complex assembly; MF: protein-containing complex binding, ubiquitin protein ligase binding, ubiquitin-like ligase-substrate adaptor activity; CC: Cul4-RING E3 ubiquitin ligase complex, Cul4A-RING E3 ubiquitin ligase complex, cullin-RING ubiquitin ligase complex, nucleus
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System, Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: Q9D0A0
Entrez ID: 76375
|
Does Knockout of Tmem268 in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,398
|
Knockout
|
Tmem268
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Tmem268 (transmembrane protein 268)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, membrane, plasma membrane
Pathways:
UniProt: Q8R239
Entrez ID: 230279
|
Does Knockout of Tead4 in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Tead4
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Tead4 (TEA domain family member 4)
Type: protein-coding
Summary: This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is preferentially expressed in the skeletal muscle, and binds to the M-CAT regulatory element found in promoters of muscle-specific genes to direct their gene expression. This factor may play a role in the embryonic development of skeletal muscle. Alternatively spliced transcripts encoding distinct isoforms, which are translated through the use of a non-AUG (AUU) initiation codon, have been described for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA-templated transcription, blastocyst formation, cell fate commitment, cell fate specification, embryo implantation, embryonic organ development, hippo signaling, in utero embryonic development, positive regulation of DNA-templated transcription, positive regulation of stem cell population maintenance, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, trophectodermal cell fate commitment; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, protein binding, sequence-specific DNA binding; CC: cytoplasm, nucleoplasm, nucleus, protein-DNA complex, transcription regulator complex
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Hippo signaling pathway - Mus musculus (mouse), Hippo signaling pathway - multiple species - Mus musculus (mouse), RNA Polymerase II Transcription, RUNX3 regulates YAP1-mediated transcription, Transcriptional regulation by RUNX3, YAP1- and WWTR1 (TAZ)-stimulated gene expression
UniProt: Q62296
Entrez ID: 21679
|
Does Knockout of Tmem132d in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
Tmem132d
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Tmem132d (transmembrane protein 132D)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q76HP3
Entrez ID: 243274
|
Does Knockout of Dgat2 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,174
|
Knockout
|
Dgat2
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Dgat2 (diacylglycerol O-acyltransferase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to oleic acid, cholesterol homeostasis, diacylglycerol biosynthetic process, diacylglycerol metabolic process, fat pad development, fatty acid homeostasis, glycerol metabolic process, intracellular triglyceride homeostasis, lipid metabolic process, lipid storage, long-chain fatty-acyl-CoA metabolic process, low-density lipoprotein particle clearance, monoacylglycerol biosynthetic process, negative regulation of fatty acid oxidation, positive regulation of gluconeogenesis, positive regulation of triglyceride biosynthetic process, regulation of cholesterol metabolic process, regulation of lipoprotein metabolic process, regulation of plasma lipoprotein particle levels, response to nutrient, retinol metabolic process, triglyceride biosynthetic process; MF: 2-acylglycerol O-acyltransferase activity, O-acyltransferase activity, acyltransferase activity, diacylglycerol O-acyltransferase activity, protein homodimerization activity, retinol O-fatty-acyltransferase activity, transferase activity; CC: cytoplasm, cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, lipid droplet, membrane, mitochondrion, perinuclear endoplasmic reticulum membrane, perinuclear region of cytoplasm
Pathways: Acyl chain remodeling of DAG and TAG, Fat digestion and absorption - Mus musculus (mouse), Glycerolipid metabolism - Mus musculus (mouse), Glycerophospholipid biosynthesis, Metabolism, Metabolism of lipids, Phospholipid metabolism, Triglyceride biosynthesis, Triglyceride metabolism, triacylglycerol biosynthesis, wax esters biosynthesis II
UniProt: Q9DCV3
Entrez ID: 67800
|
Does Knockout of Zfyve28 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,285
|
Knockout
|
Zfyve28
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Zfyve28 (zinc finger, FYVE domain containing 28)
Type: protein-coding
Summary: Predicted to enable phosphatidylinositol-3-phosphate binding activity. Predicted to be involved in negative regulation of epidermal growth factor-activated receptor activity. Predicted to be located in cytosol. Predicted to be active in early endosome membrane. Orthologous to human ZFYVE28 (zinc finger FYVE-type containing 28). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: negative regulation of epidermal growth factor receptor signaling pathway, negative regulation of epidermal growth factor-activated receptor activity; MF: metal ion binding, phosphatidylinositol-3-phosphate binding, zinc ion binding; CC: cytoplasm, cytosol, early endosome membrane, endosome, membrane
Pathways:
UniProt: Q6ZPK7
Entrez ID: 231125
|
Does Knockout of Guk1 in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Guk1
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Guk1 (guanylate kinase 1)
Type: protein-coding
Summary: Enables ATP binding activity and guanylate kinase activity. Involved in purine nucleotide metabolic process. Located in cytosol and photoreceptor inner segment. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome-21. Orthologous to human GUK1 (guanylate kinase 1). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: GDP biosynthetic process, GDP metabolic process, GDP-mannose metabolic process, GMP metabolic process, dATP metabolic process, dGDP biosynthetic process, dGMP metabolic process, glycoprotein transport, purine nucleotide metabolic process, xenobiotic metabolic process; MF: ATP binding, GMP kinase activity, kinase activity, nucleotide binding, transferase activity; CC: cytoplasm, cytosol, mitochondrion, photoreceptor inner segment
Pathways: Azathioprine ADME, Drug ADME, Interconversion of nucleotide di- and triphosphates, Metabolism, Metabolism of nucleotides, Purine metabolism - Mus musculus (mouse), purine and pyrimidine metabolism
UniProt: Q64520
Entrez ID: 14923
|
Does Knockout of Wdr54 in Immortal mouse chromaffin cells causally result in cell viability?
| 0
| 2,469
|
Knockout
|
Wdr54
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Wdr54 (WD repeat domain 54)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: fusion of sperm to egg plasma membrane involved in single fertilization, negative regulation of receptor internalization, regulation of MAPK cascade, regulation of epidermal growth factor receptor signaling pathway, single fertilization; MF: protein homodimerization activity; CC: cytoplasm, membrane, motile cilium, plasma membrane, vesicle
Pathways:
UniProt: Q9R0D8
Entrez ID: 75659
|
Does Knockout of Gm5108 in breast epithelium causally result in cell cycle progression?
| 0
| 1,469
|
Knockout
|
Gm5108
|
cell cycle progression
|
breast epithelium
|
Gene: Gm5108 (predicted gene 5108)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 330097
|
Does Knockout of Cgn in Immortal mouse chromaffin cells causally result in cell viability?
| 0
| 2,469
|
Knockout
|
Cgn
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Cgn (cingulin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: bicellular tight junction assembly, epithelial cell morphogenesis, microtubule cytoskeleton organization; MF: actin binding, microtubule binding, protein binding; CC: anchoring junction, apical junction complex, bicellular tight junction, brush border, cell junction, myosin complex, plasma membrane
Pathways: Tight junction - Mus musculus (mouse)
UniProt: A0A5F8MPT6, E9QMC1, D3YUW7, A0A0G2JFG0, A0A0G2JEK8
Entrez ID: 70737
|
Does Knockout of Hspa1l in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
Hspa1l
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Hspa1l (heat shock protein 1-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: binding of sperm to zona pellucida, cell differentiation, positive regulation of protein targeting to mitochondrion, protein folding, protein refolding, spermatogenesis; MF: ATP binding, ATP hydrolysis activity, ATP-dependent protein folding chaperone, heat shock protein binding, nucleotide binding, protein folding chaperone, ubiquitin protein ligase binding, unfolded protein binding; CC: COP9 signalosome, cell body, cytoplasm, cytosol, nucleus, plasma membrane, zona pellucida receptor complex
Pathways: Antigen processing and presentation - Mus musculus (mouse), Antiviral mechanism by IFN-stimulated genes, Attenuation phase, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Cytokine Signaling in Immune system, Endocytosis - Mus musculus (mouse), Estrogen signaling pathway - Mus musculus (mouse), HSF1-dependent transactivation, HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand, Immune System, Interferon Signaling, Legionellosis - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), Longevity regulating pathway - multiple species - Mus musculus (mouse), MAPK signaling pathway - Mus musculus (mouse), Measles - Mus musculus (mouse), PKR-mediated signaling, Prion disease - Mus musculus (mouse), Protein processing in endoplasmic reticulum - Mus musculus (mouse), Regulation of HSF1-mediated heat shock response, Spliceosome - Mus musculus (mouse), Toxoplasmosis - Mus musculus (mouse)
UniProt: P16627
Entrez ID: 15482
|
Does Knockout of Fbxo25 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Fbxo25
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Fbxo25 (F-box protein 25)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein ubiquitination; MF: actin binding, protein binding; CC: SCF ubiquitin ligase complex, cytoplasm, nucleus
Pathways: FoxO signaling pathway - Mus musculus (mouse)
UniProt: Q9D2Y6
Entrez ID: 66822
|
Does Knockout of Brwd3 in Melanoma Cell Line causally result in tumorigenicity?
| 0
| 2,186
|
Knockout
|
Brwd3
|
tumorigenicity
|
Melanoma Cell Line
|
Gene: Brwd3 (bromodomain and WD repeat domain containing 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoskeleton organization, regulation of cell shape, regulation of transcription by RNA polymerase II
Pathways:
UniProt: A2AHJ4
Entrez ID: 382236
|
Does Knockout of Slc7a5 in Cytotoxic T-lymphocyte (CD8+ T cells) causally result in cell proliferation?
| 1
| 2,412
|
Knockout
|
Slc7a5
|
cell proliferation
|
Cytotoxic T-lymphocyte (CD8+ T cells)
|
Gene: Slc7a5 (solute carrier family 7 (cationic amino acid transporter, y+ system), member 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: L-amino acid transport, L-histidine transport, L-leucine import across plasma membrane, L-leucine transport, L-tryptophan transmembrane transport, alanine transport, amino acid import across plasma membrane, amino acid transmembrane transport, amino acid transport, cellular response to L-arginine, cellular response to amino acid stimulus, cellular response to glucose starvation, cellular response to lipopolysaccharide, isoleucine transport, liver regeneration, methionine transport, negative regulation of autophagy, negative regulation of gene expression, negative regulation of vascular associated smooth muscle cell apoptotic process, neutral amino acid transport, phenylalanine transport, positive regulation of L-leucine import across plasma membrane, positive regulation of glial cell proliferation, positive regulation of interleukin-17 production, positive regulation of interleukin-4 production, positive regulation of type II interferon production, proline transport, response to hyperoxia, response to muscle activity, thyroid hormone transport, transmembrane transport, tryptophan transport, tyrosine transport, valine transport, xenobiotic transport; MF: L-amino acid transmembrane transporter activity, L-leucine transmembrane transporter activity, L-tryptophan transmembrane transporter activity, amino acid transmembrane transporter activity, antiporter activity, aromatic amino acid transmembrane transporter activity, neutral L-amino acid transmembrane transporter activity, protein binding, thyroid hormone transmembrane transporter activity, transmembrane transporter activity; CC: amino acid transport complex, apical plasma membrane, basal plasma membrane, basolateral plasma membrane, cytosol, external side of apical plasma membrane, lysosomal membrane, lysosome, membrane, microvillus membrane, plasma membrane
Pathways: Amino acid transport across the plasma membrane, Basigin interactions, Cell surface interactions at the vascular wall, Central carbon metabolism in cancer - Mus musculus (mouse), Hemostasis, Metabolism, Metabolism of amino acids and derivatives, SLC-mediated transmembrane transport, SLC-mediated transport of amino acids, Transport of small molecules, Tryptophan catabolism, mTOR signaling pathway - Mus musculus (mouse)
UniProt: Q9Z127
Entrez ID: 20539
|
Does Knockout of Sec11c in Regulatory T cell causally result in cell proliferation?
| 0
| 2,127
|
Knockout
|
Sec11c
|
cell proliferation
|
Regulatory T cell
|
Gene: Sec11c (SEC11 homolog C, signal peptidase complex subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: proteolysis, signal peptide processing; MF: hydrolase activity, peptidase activity, serine-type endopeptidase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, signal peptidase complex
Pathways: Adherens junctions interactions, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Metabolism of proteins, Peptide hormone metabolism, Protein export - Mus musculus (mouse), Regulation of CDH1 Expression and Function, Regulation of CDH1 posttranslational processing and trafficking to plasma membrane, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Synthesis, secretion, and deacylation of Ghrelin
UniProt: Q9D8V7
Entrez ID: 66286
|
Does Knockout of Sephs2 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 1,565
|
Knockout
|
Sephs2
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Sephs2 (selenophosphate synthetase 2)
Type: protein-coding
Summary: This gene encodes an enzyme that catalyzes the production of monoselenophosphate (MSP) from selenide and ATP. MSP is the selenium donor required for synthesis of selenocysteine (Sec), which is co-translationally incorporated into selenoproteins at in-frame UGA codons that normally signal translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is itself a selenoprotein containing a Sec residue at its active site, suggesting the existence of an autoregulatory mechanism. It is preferentially expressed in tissues implicated in the synthesis of selenoproteins and in sites of blood cell development. [provided by RefSeq, May 2017].
Gene Ontology: BP: selenium compound metabolic process, selenocysteine biosynthetic process, selenocysteine metabolic process; MF: ATP binding, kinase activity, metal ion binding, nucleotide binding, selenide, water dikinase activity, transferase activity
Pathways: Metabolism, Metabolism of amino acids and derivatives, Selenoamino acid metabolism, Selenocompound metabolism - Mus musculus (mouse), Selenocysteine synthesis, selenocysteine biosynthesis II (archaea and eukaryotes)
UniProt: P97364
Entrez ID: 20768
|
Does Knockout of Eif3i in macrophage causally result in phagocytosis?
| 0
| 1,889
|
Knockout
|
Eif3i
|
phagocytosis
|
macrophage
|
Gene: Eif3i (eukaryotic translation initiation factor 3, subunit I)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translational initiation, formation of cytoplasmic translation initiation complex, translation, translational initiation; MF: RNA binding, protein binding, translation initiation factor activity; CC: cytoplasm, eukaryotic 43S preinitiation complex, eukaryotic 48S preinitiation complex, eukaryotic translation initiation factor 3 complex, eukaryotic translation initiation factor 3 complex, eIF3m, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Metabolism of proteins, Ribosomal scanning and start codon recognition, Translation, Translation initiation complex formation
UniProt: Q9QZD9
Entrez ID: 54709
|
Does Knockout of Psg29 in Neuroblastoma Cell Line causally result in response to virus?
| 0
| 1,422
|
Knockout
|
Psg29
|
response to virus
|
Neuroblastoma Cell Line
|
Gene: Psg29 (pregnancy-specific beta-1-glycoprotein 29)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of immune system process, signal transduction; CC: cell surface, plasma membrane
Pathways: Cell surface interactions at the vascular wall, Hemostasis, Immune System, Innate Immune System, Metabolism of proteins, Neutrophil degranulation, Post-translational modification: synthesis of GPI-anchored proteins, Post-translational protein modification
UniProt: Q3URN6
Entrez ID: 114872
|
Does Knockout of Lama3 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
Lama3
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Lama3 (laminin, alpha 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: animal organ morphogenesis, axon guidance, cell adhesion, cell-cell adhesion, endodermal cell differentiation, hemidesmosome assembly, regulation of cell adhesion, regulation of cell migration, regulation of embryonic development, tissue development; MF: extracellular matrix structural constituent, signaling receptor binding; CC: adherens junction, basement membrane, endoplasmic reticulum, extracellular matrix, extracellular region, hemidesmosome, laminin complex, laminin-3 complex, laminin-5 complex
Pathways: Amoebiasis - Mus musculus (mouse), ECM-receptor interaction - Mus musculus (mouse), Focal adhesion - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Small cell lung cancer - Mus musculus (mouse), Toxoplasmosis - Mus musculus (mouse)
UniProt: Q61789
Entrez ID: 16774
|
Does Knockout of Gnat3 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 161
|
Knockout
|
Gnat3
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Gnat3 (G protein subunit alpha transducin 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, adenylate cyclase-modulating G protein-coupled receptor signaling pathway, detection of light stimulus involved in visual perception, phototransduction, visible light, response to nicotine, sensory perception of bitter taste, sensory perception of sweet taste, sensory perception of taste, sensory perception of umami taste, signal transduction; MF: G protein-coupled receptor binding, G-protein beta/gamma-subunit complex binding, GTP binding, GTPase activity, guanyl nucleotide binding, metal ion binding, nucleotide binding; CC: acrosomal vesicle, apical plasma membrane, axoneme, cytoplasm, heterotrimeric G-protein complex, membrane, plasma membrane, protein-containing complex
Pathways: ADP signalling through P2Y purinoceptor 12, Activation of GABAB receptors, Adenylate cyclase inhibitory pathway, Carbohydrate digestion and absorption - Mus musculus (mouse), ESR-mediated signaling, Extra-nuclear estrogen signaling, G alpha (i) signalling events, G-protein mediated events, GABA B receptor activation, GABA receptor activation, GPCR downstream signalling, Hemostasis, Incretin synthesis, secretion, and inactivation, Metabolism of proteins, Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, Opioid Signalling, Peptide hormone metabolism, Platelet activation, signaling and aggregation, Sensory Perception, Sensory perception of sweet, bitter, and umami (glutamate) taste, Sensory perception of taste, Signal Transduction, Signal amplification, Signaling by GPCR, Signaling by Nuclear Receptors, Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1), Taste transduction - Mus musculus (mouse), Transmission across Chemical Synapses
UniProt: Q3V3I2
Entrez ID: 242851
|
Does Knockout of Zeb2 in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Zeb2
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Zeb2 (zinc finger E-box binding homeobox 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: astrocyte activation, cell proliferation in forebrain, central nervous system development, collateral sprouting, corpus callosum morphogenesis, corticospinal tract morphogenesis, developmental pigmentation, embryonic morphogenesis, endothelial cell migration, endothelial cell proliferation, fibroblast activation, hippocampus development, mammillary axonal complex development, melanocyte migration, myofibroblast differentiation, negative regulation of fibroblast migration, negative regulation of transcription by RNA polymerase II, neural crest cell migration, neural tube closure, positive regulation of Wnt signaling pathway, positive regulation of axonogenesis, positive regulation of canonical Wnt signaling pathway, positive regulation of lens fiber cell differentiation, positive regulation of melanin biosynthetic process, positive regulation of melanocyte differentiation, positive regulation of myofibroblast contraction, positive regulation of transcription by RNA polymerase II, positive regulation of transforming growth factor beta receptor signaling pathway, pyroptotic inflammatory response, regulation of blood-brain barrier permeability, regulation of melanosome organization, regulation of myofibroblast cell apoptotic process, regulation of transcription by RNA polymerase II, response to oxygen-glucose deprivation, somitogenesis, stress fiber assembly; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, R-SMAD binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: chromatin, chromosome, nucleolus, nucleoplasm, nucleus, plasma membrane
Pathways: Adherens junctions interactions, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, MicroRNAs in cancer - Mus musculus (mouse), Regulation of CDH11 Expression and Function, Regulation of CDH11 gene transcription, Regulation of Expression and Function of Type II Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion
UniProt: Q9R0G7
Entrez ID: 24136
|
Does Knockout of Plekhf2 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Plekhf2
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Plekhf2 (pleckstrin homology domain containing, family F (with FYVE domain) member 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: endosome organization, endosome to lysosome transport, protein transport; MF: metal ion binding, phosphatidylinositol binding, zinc ion binding; CC: cytoplasmic vesicle, early endosome, early endosome membrane, endomembrane system, endoplasmic reticulum, endosome, membrane, transport vesicle
Pathways:
UniProt: Q91WB4
Entrez ID: 71801
|
Does Knockout of Zar1l in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,263
|
Knockout
|
Zar1l
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Zar1l (zygote arrest 1-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, negative regulation of translation, oocyte maturation, oogenesis, translation; MF: RNA binding, mRNA 3'-UTR binding, mRNA binding, metal ion binding, protein binding, zinc ion binding; CC: cytoplasm, cytoplasmic ribonucleoprotein granule, intracellular membraneless organelle
Pathways:
UniProt: C3VD30
Entrez ID: 545824
|
Does Knockout of Dynlrb1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,259
|
Knockout
|
Dynlrb1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Dynlrb1 (dynein light chain roadblock-type 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: microtubule-based movement, visual behavior; MF: dynein intermediate chain binding, identical protein binding, protein binding; CC: centrosome, cytoplasm, cytoplasmic dynein complex, cytoskeleton, dynein complex, microtubule
Pathways: Cilium Assembly, Intraflagellar transport, Organelle biogenesis and maintenance, Salmonella infection - Mus musculus (mouse)
UniProt: P62627
Entrez ID: 67068
|
Does Knockout of Pogk in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,308
|
Knockout
|
Pogk
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Pogk (pogo transposable element with KRAB domain)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, regulation of DNA-templated transcription; MF: DNA binding, molecular_function, nucleic acid binding; CC: nucleoplasm, nucleus
Pathways:
UniProt: Q80TC5
Entrez ID: 71592
|
Does Knockout of Mmel1 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Mmel1
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Mmel1 (membrane metallo-endopeptidase-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein processing, proteolysis; MF: endopeptidase activity, hydrolase activity, metal ion binding, metalloendopeptidase activity, metallopeptidase activity, peptidase activity, zinc ion binding; CC: Golgi apparatus, endoplasmic reticulum, extracellular region, extracellular space, membrane, plasma membrane
Pathways:
UniProt: Q9JLI3
Entrez ID: 27390
|
Does Knockout of Cndp2 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Cndp2
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Cndp2 (CNDP dipeptidase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: proteolysis; MF: carboxypeptidase activity, dipeptidase activity, hydrolase activity, metal ion binding, metallodipeptidase activity, metallopeptidase activity, peptidase activity; CC: cytoplasm, cytosol, nucleoplasm
Pathways: Arginine and proline metabolism - Mus musculus (mouse), Biological oxidations, Drug ADME, Glutathione conjugation, Glutathione synthesis and recycling, Histidine metabolism - Mus musculus (mouse), Metabolism, Paracetamol ADME, Phase II - Conjugation of compounds, beta-Alanine metabolism - Mus musculus (mouse)
UniProt: Q9D1A2
Entrez ID: 66054
|
Does Knockout of Col6a4 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Col6a4
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Col6a4 (collagen, type VI, alpha 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, extracellular matrix organization; MF: collagen binding, extracellular matrix structural constituent conferring tensile strength; CC: collagen trimer, collagen type VI trimer, extracellular matrix, extracellular region, protein-containing complex
Pathways: ECM-receptor interaction - Mus musculus (mouse), Focal adhesion - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), Protein digestion and absorption - Mus musculus (mouse)
UniProt: A2AX52
Entrez ID: 68553
|
Does Knockout of Iffo2 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Iffo2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Iffo2 (intermediate filament family orphan 2)
Type: protein-coding
Summary: Predicted to be located in intermediate filament. Is expressed in 4th ventricle; axial skeleton; choroid plexus; lateral ventricle choroid plexus; and rib. Orthologous to human IFFO2 (intermediate filament family orphan 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: CC: cellular_component, intermediate filament
Pathways:
UniProt: Q8R2V2
Entrez ID: 212632
|
Does Knockout of Cnpy1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
Cnpy1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Cnpy1 (canopy FGF signaling regulator 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q4VAB4
Entrez ID: 269637
|
Does Knockout of Ube2ql1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 83
|
Knockout
|
Ube2ql1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Ube2ql1 (ubiquitin-conjugating enzyme E2Q family-like 1)
Type: protein-coding
Summary: Predicted to enable ubiquitin conjugating enzyme activity. Predicted to be involved in protein polyubiquitination. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be active in nucleus. Is expressed in bone; central nervous system; dorsal root ganglion; heart; and liver. Orthologous to human UBE2QL1 (ubiquitin conjugating enzyme E2 QL1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: protein polyubiquitination, protein ubiquitination; MF: ATP binding, nucleotide binding, transferase activity, ubiquitin conjugating enzyme activity; CC: nucleoplasm, nucleus, plasma membrane
Pathways: Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: A0PJN4
Entrez ID: 76980
|
Does Knockout of Add2 in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Add2
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Add2 (adducin 2)
Type: protein-coding
Summary: This gene encodes the beta subunit of the adducin family. Adducins, encoded by alpha, beta and gamma genes, are heteromeric proteins that crosslink actin filaments with spectrin at the cytoskeletal membrane. This protein, primarily found in the brain and hematopoietic cells, is regulated by phosphorylation and calmodulin interactions as it promotes spectrin assembly onto actin filaments, bundles actin and caps barbed ends of actin filaments. In mouse, deficiency of this gene can lead to mild hemolytic anemia and impaired synaptic plasticity. Mutations of this gene in mouse serve as a pathophysiological model for hereditary spherocytosis and hereditary elliptocytosis. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Dec 2012].
Gene Ontology: BP: actin cytoskeleton organization, actin filament bundle assembly, barbed-end actin filament capping, hemopoiesis, leukocyte migration, leukocyte tethering or rolling, monoatomic ion transport, protein-containing complex assembly, synapse assembly; MF: actin binding, actin filament binding, calmodulin binding, cytoskeletal anchor activity, protein dimerization activity, protein heterodimerization activity, protein homodimerization activity, protein kinase binding, spectrin binding, structural constituent of cytoskeleton; CC: F-actin capping protein complex, cytoplasm, cytoplasmic vesicle, cytoskeleton, glutamatergic synapse, membrane, plasma membrane, plasma membrane raft, postsynapse, postsynaptic density
Pathways: Miscellaneous transport and binding events, Transport of small molecules
UniProt: Q9QYB8
Entrez ID: 11519
|
Does Knockout of Pcsk6 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 163
|
Knockout
|
Pcsk6
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Pcsk6 (proprotein convertase subtilisin/kexin type 6)
Type: protein-coding
Summary: Predicted to enable heparin binding activity; nerve growth factor binding activity; and serine-type endopeptidase activity. Acts upstream of or within determination of left/right symmetry; protein processing; and zygotic determination of anterior/posterior axis, embryo. Predicted to be active in several cellular components, including cell surface; collagen-containing extracellular matrix; and extracellular space. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; limb; and skeleton. Orthologous to human PCSK6 (proprotein convertase subtilisin/kexin type 6). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: determination of left/right symmetry, glycoprotein metabolic process, nerve growth factor production, peptide hormone processing, protein processing, proteolysis, secretion by cell, zygotic determination of anterior/posterior axis, embryo; MF: endopeptidase activity, heparin binding, hydrolase activity, nerve growth factor binding, peptidase activity, serine-type endopeptidase activity, serine-type peptidase activity; CC: cell surface, cytoplasmic vesicle, endoplasmic reticulum lumen, extracellular matrix, extracellular space, membrane
Pathways: Adherens junctions interactions, Assembly of active LPL and LIPC lipase complexes, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Expression and Processing of Neurotrophins, NGF processing, Plasma lipoprotein assembly, remodeling, and clearance, Plasma lipoprotein remodeling, Regulation of CDH1 Expression and Function, Regulation of CDH1 posttranslational processing and trafficking to plasma membrane, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Signal Transduction, Signaling by NTRKs, Signaling by Receptor Tyrosine Kinases, Transport of small molecules
UniProt: E9Q4D0, F6XJP7, H3BJL4, H3BLN2
Entrez ID: 18553
|
Does Knockout of Rnls in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Rnls
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Rnls (renalase, FAD-dependent amine oxidase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cardiac left ventricle morphogenesis, dopamine metabolic process, epinephrine metabolic process, heart contraction, negative regulation of blood pressure, negative regulation of heart rate, norepinephrine metabolic process, phosphate ion homeostasis, regulation of systemic arterial blood pressure, response to norepinephrine, response to salt; MF: NADH binding, epinephrine binding, monoamine oxidase activity, oxidoreductase activity, oxidoreductase activity, acting on NAD(P)H; CC: extracellular region, extracellular space
Pathways:
UniProt:
Entrez ID: 67795
|
Does Knockout of Uqcr10 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,259
|
Knockout
|
Uqcr10
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Uqcr10 (ubiquinol-cytochrome c reductase, complex III subunit X)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular respiration, mitochondrial electron transport, ubiquinol to cytochrome c; CC: membrane, mitochondrial inner membrane, mitochondrion, respiratory chain complex III
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Cardiac muscle contraction - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Complex III assembly, Diabetic cardiomyopathy - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Metabolism, Non-alcoholic fatty liver disease - Mus musculus (mouse), Oxidative phosphorylation - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Respiratory electron transport, Thermogenesis - Mus musculus (mouse), aerobic respiration -- electron donor II
UniProt: Q8R1I1
Entrez ID: 66152
|
Does Knockout of Dleu7 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Dleu7
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Dleu7 (deleted in lymphocytic leukemia, 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q8CHZ8
Entrez ID: 239133
|
Does Knockout of Timm17a in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Timm17a
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Timm17a (translocase of inner mitochondrial membrane 17a)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of protein processing, protein import into mitochondrial matrix, protein transport; MF: enzyme binding, protein transmembrane transporter activity; CC: TIM23 mitochondrial import inner membrane translocase complex, membrane, mitochondrial inner membrane, mitochondrion, nucleoplasm
Pathways:
UniProt: Q9Z0V8
Entrez ID: 21854
|
Does Knockout of Mbd3l2 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,269
|
Knockout
|
Mbd3l2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Mbd3l2 (methyl-CpG binding domain protein 3-like 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA methylation-dependent constitutive heterochromatin formation, biological_process, negative regulation of transcription by RNA polymerase II; MF: methyl-CpG binding, molecular_function; CC: cellular_component, nucleus
Pathways:
UniProt: Q6P237, Q3UXB0
Entrez ID: 234988
|
Does Knockout of Cyp4a31 in Microglial Cell Line causally result in phagocytosis?
| 0
| 1,587
|
Knockout
|
Cyp4a31
|
phagocytosis
|
Microglial Cell Line
|
Gene: Cyp4a31 (cytochrome P450, family 4, subfamily a, polypeptide 31)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: arachidonate metabolic process, fatty acid metabolic process, icosanoid biosynthetic process, kidney development, lauric acid metabolic process, linoleic acid metabolic process; MF: 16-hydroxypalmitate dehydrogenase activity, alkane 1-monooxygenase activity, arachidonate epoxygenase activity, arachidonate monooxygenase activity, heme binding, iron ion binding, leukotriene-B4 20-monooxygenase activity, long-chain fatty acid omega-hydroxylase activity, medium-chain fatty acid omega-hydroxylase activity, metal ion binding, monooxygenase activity, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; CC: apical plasma membrane, cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, extracellular space, intracellular membrane-bounded organelle, membrane
Pathways: Arachidonate metabolism, Arachidonic acid metabolism - Mus musculus (mouse), Biological oxidations, Cytochrome P450 - arranged by substrate type, Eicosanoids, Fatty acid degradation - Mus musculus (mouse), Fatty acid metabolism, Fatty acids, Inflammatory mediator regulation of TRP channels - Mus musculus (mouse), Metabolism, Metabolism of lipids, Miscellaneous substrates, PPAR signaling pathway - Mus musculus (mouse), Phase I - Functionalization of compounds, Retinol metabolism - Mus musculus (mouse), Synthesis of Leukotrienes (LT) and Eoxins (EX), Vascular smooth muscle contraction - Mus musculus (mouse)
UniProt: F8WGU9, Q91WU1, A2A8S8, A2A8S9
Entrez ID: 666168
|
Does Knockout of Commd7 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,284
|
Knockout
|
Commd7
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Commd7 (COMM domain containing 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of DNA-templated transcription, tumor necrosis factor-mediated signaling pathway; MF: NF-kappaB binding
Pathways: Metabolism of proteins, Neddylation, Post-translational protein modification
UniProt: Q8BG94
Entrez ID: 99311
|
Does Knockout of P2rx3 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
P2rx3
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: P2rx3 (purinergic receptor P2X, ligand-gated ion channel, 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: behavioral response to formalin induced pain, behavioral response to pain, calcium ion transmembrane transport, cellular response to ATP, chemical synaptic transmission, establishment of localization in cell, excitatory postsynaptic potential, inorganic cation transmembrane transport, modulation of chemical synaptic transmission, monoatomic cation transmembrane transport, monoatomic cation transport, monoatomic ion transmembrane transport, monoatomic ion transport, neuromuscular synaptic transmission, neuronal action potential, peristalsis, protein homotrimerization, purinergic nucleotide receptor signaling pathway, regulation of synaptic plasticity, response to ATP, response to carbohydrate, response to cold, response to heat, response to hypoxia, response to mechanical stimulus, response to temperature stimulus, sensory perception of taste, urinary bladder smooth muscle contraction; MF: ATP binding, extracellularly ATP-gated monoatomic cation channel activity, identical protein binding, metal ion binding, monoatomic ion channel activity, nucleotide binding, purinergic nucleotide receptor activity; CC: Schaffer collateral - CA1 synapse, axon, dendritic spine, hippocampal mossy fiber to CA3 synapse, membrane, neuron projection, neuronal cell body, plasma membrane, postsynapse, presynaptic membrane, receptor complex, terminal bouton
Pathways: Calcium signaling pathway - Mus musculus (mouse), Elevation of cytosolic Ca2+ levels, Hemostasis, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Platelet calcium homeostasis, Platelet homeostasis, Taste transduction - Mus musculus (mouse)
UniProt: Q3UR32
Entrez ID: 228139
|
Does Knockout of BC004004 in Embryonic Fibroblast Cell Line causally result in cell proliferation?
| 0
| 345
|
Knockout
|
BC004004
|
cell proliferation
|
Embryonic Fibroblast Cell Line
|
Gene: BC004004 (cDNA sequence BC004004)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagy, chromatin remodeling, collagen metabolic process, connective tissue replacement, epithelial cell proliferation, fibroblast proliferation, positive regulation of cell cycle, response to bleomycin, wound healing; MF: molecular_function, protein binding; CC: Golgi apparatus, Golgi membrane, cytoplasm, membrane, midbody, nucleolus, plasma membrane
Pathways:
UniProt: Q99KU6
Entrez ID: 80748
|
Does Knockout of Cldn34b4 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 161
|
Knockout
|
Cldn34b4
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Cldn34b4 (claudin 34B4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: bicellular tight junction assembly, cell adhesion; MF: molecular_function, structural molecule activity; CC: anchoring junction, bicellular tight junction, membrane, plasma membrane
Pathways:
UniProt: Q3V0X2
Entrez ID: 619294
|
Does Knockout of Tenm2 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,685
|
Knockout
|
Tenm2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Tenm2 (teneurin transmembrane protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, cell-cell adhesion, negative regulation of transcription by RNA polymerase II, neuron development, positive regulation of filopodium assembly, retrograde trans-synaptic signaling by trans-synaptic protein complex, signal transduction; MF: cell adhesion molecule binding, identical protein binding, protein binding, protein heterodimerization activity, protein homodimerization activity, signaling receptor binding; CC: Golgi apparatus, PML body, cell junction, cell projection, cell-cell junction, dendrite, dendritic spine, endoplasmic reticulum, extrinsic component of postsynaptic membrane, filopodium, glutamatergic synapse, growth cone, membrane, neuron projection, nucleus, plasma membrane, postsynaptic membrane, presynaptic membrane, synapse
Pathways:
UniProt: A0A0A0MQ92, A0A0A0MQB7, B9EJ72
Entrez ID: 23964
|
Does Knockout of Tmem255a in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Tmem255a
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Tmem255a (transmembrane protein 255A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, membrane
Pathways:
UniProt: Q8BHW5
Entrez ID: 245386
|
Does Knockout of Mis18a in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 167
|
Knockout
|
Mis18a
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Mis18a (MIS18 kinetochore protein A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CENP-A containing chromatin assembly, cell division, chromosome segregation, heterochromatin formation, pericentric heterochromatin organization, protein localization to chromosome, centromeric region; MF: identical protein binding, metal ion binding, protein binding, protein-macromolecule adaptor activity; CC: CENP-A recruiting complex, chromatin, chromosome, chromosome, centromeric region, cytosol, nucleoplasm, nucleus
Pathways: Cell Cycle, Chromosome Maintenance, Deposition of new CENPA-containing nucleosomes at the centromere, Nucleosome assembly
UniProt: Q9CZJ6
Entrez ID: 66578
|
Does Knockout of Bin2 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Bin2
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Bin2 (bridging integrator 2)
Type: protein-coding
Summary: Predicted to enable phospholipid binding activity. Predicted to be involved in several processes, including phagocytosis, engulfment; plasma membrane tubulation; and podosome assembly. Predicted to be located in anchoring junction; cell cortex; and cell projection. Predicted to be active in plasma membrane and podosome. Predicted to colocalize with phagocytic cup. Is expressed in liver and thymus primordium. Orthologous to human BIN2 (bridging integrator 2). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: cell chemotaxis, phagocytosis, engulfment, plasma membrane tubulation, podosome assembly; MF: phospholipid binding; CC: anchoring junction, cell cortex, cell projection, cytoplasm, membrane, phagocytic cup, plasma membrane, podosome
Pathways:
UniProt: S4R1B8, S4R270, S4R171, S4R2J8, A0A5F8MQ05, S4R1Q1
Entrez ID: 668218
|
Does Knockout of Igsf9 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Igsf9
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Igsf9 (immunoglobulin superfamily, member 9)
Type: protein-coding
Summary: Enables cell-cell adhesion mediator activity. Acts upstream of or within dendrite development; homophilic cell adhesion via plasma membrane adhesion molecules; and regulation of synapse organization. Located in axon; dendrite; and inhibitory synapse. Is expressed in several structures, including alimentary system; central nervous system; limb; sensory organ; and urinary system. Orthologous to human IGSF9 (immunoglobulin superfamily member 9). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cell differentiation, cell-cell adhesion, dendrite development, homophilic cell adhesion via plasma membrane adhesion molecules, nervous system development, regulation of synapse maturation, regulation of synapse organization; CC: axon, dendrite, glutamatergic synapse, inhibitory synapse, membrane, plasma membrane, postsynaptic density membrane, synapse
Pathways:
UniProt: Q05BQ1
Entrez ID: 93842
|
Does Knockout of Pnrc2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,284
|
Knockout
|
Pnrc2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Pnrc2 (proline-rich nuclear receptor coactivator 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mRNA metabolic process, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; CC: Golgi apparatus, P-body, cytoplasm, nucleoplasm, nucleus
Pathways: Metabolism of RNA, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD)
UniProt: Q9CR73
Entrez ID: 52830
|
Does Knockout of Tmem45a2 in macrophage causally result in phagocytosis?
| 0
| 1,890
|
Knockout
|
Tmem45a2
|
phagocytosis
|
macrophage
|
Gene: Tmem45a2 (transmembrane protein 45A2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, membrane
Pathways:
UniProt: Q8CEZ6, B7ZWJ5
Entrez ID: 69457
|
Does Knockout of Lima1 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Lima1
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Lima1 (LIM domain and actin binding 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin filament bundle assembly, cell migration, cholesterol homeostasis, cholesterol metabolic process, intestinal cholesterol absorption, lipid metabolic process, negative regulation of actin filament depolymerization, negative regulation of cell migration, negative regulation of cilium assembly, positive regulation of actin filament bundle assembly, regulation of lamellipodium organization, ruffle organization, steroid metabolic process; MF: actin binding, actin filament binding, actin monomer binding, metal ion binding, microtubule stabilizing activity, protein binding; CC: actin cytoskeleton, actin filament, anchoring junction, brush border, brush border membrane, cell projection, cleavage furrow, cytoplasm, cytoskeleton, cytosol, focal adhesion, lamellipodium, membrane, plasma membrane, ruffle, stress fiber
Pathways:
UniProt: Q9ERG0
Entrez ID: 65970
|
Does Knockout of Zbtb8b in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
Zbtb8b
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Zbtb8b (zinc finger and BTB domain containing 8b)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, metal ion binding, zinc ion binding; CC: cytosol, nucleoplasm, nucleus
Pathways:
UniProt: Q8CII0
Entrez ID: 215627
|
Does Knockout of Dcun1d1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,289
|
Knockout
|
Dcun1d1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Dcun1d1 (defective in cullin neddylation 1 domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of protein neddylation, protein neddylation, regulation of protein neddylation, regulation of protein ubiquitination; MF: cullin family protein binding, ubiquitin conjugating enzyme binding, ubiquitin-like protein binding; CC: cytoplasm, cytosol, nucleoplasm, nucleus, ubiquitin ligase complex
Pathways: Metabolism of proteins, Neddylation, Post-translational protein modification
UniProt: Q9QZ73
Entrez ID: 114893
|
Does Knockout of Top2a in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,276
|
Knockout
|
Top2a
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Top2a (topoisomerase (DNA) II alpha)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA metabolic process, DNA topological change, apoptotic chromosome condensation, chromatin organization, chromosome condensation, chromosome segregation, embryonic cleavage, female meiosis chromosome separation, female meiotic nuclear division, hematopoietic progenitor cell differentiation, positive regulation of apoptotic process, positive regulation of single stranded viral RNA replication via double stranded DNA intermediate, positive regulation of transcription by RNA polymerase II, regulation of circadian rhythm, resolution of meiotic recombination intermediates, rhythmic process, sister chromatid segregation; MF: ATP binding, ATP-dependent activity, acting on DNA, DNA binding, DNA binding, bending, DNA topoisomerase activity, DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity, chromatin binding, isomerase activity, magnesium ion binding, metal ion binding, nucleotide binding, protein binding, protein heterodimerization activity, protein homodimerization activity, protein kinase C binding, sequence-specific DNA binding, ubiquitin binding; CC: DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex, centriole, chromosome, centromeric region, condensed chromosome, cytoplasm, male germ cell nucleus, nuclear chromosome, nucleolus, nucleoplasm, nucleus, protein-containing complex, ribonucleoprotein complex
Pathways: Metabolism of proteins, Post-translational protein modification, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA replication proteins
UniProt: Q01320
Entrez ID: 21973
|
Does Knockout of Pex2 in Neuroblastoma Cell Line causally result in response to virus?
| 0
| 1,422
|
Knockout
|
Pex2
|
response to virus
|
Neuroblastoma Cell Line
|
Gene: Pex2 (peroxisomal biogenesis factor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: bile acid biosynthetic process, cellular response to reactive oxygen species, cholesterol homeostasis, fatty acid beta-oxidation, negative regulation of epithelial cell proliferation, negative regulation of fibroblast proliferation, nervous system development, neuron migration, peroxisome organization, pexophagy, protein destabilization, protein import into peroxisome matrix, protein import into peroxisome matrix, receptor recycling, protein import into peroxisome matrix, substrate release, protein monoubiquitination, protein transport, protein ubiquitination, protein unfolding, regulation of cholesterol biosynthetic process, response to amino acid starvation, very long-chain fatty acid metabolic process; MF: metal ion binding, transferase activity, ubiquitin protein ligase activity, zinc ion binding; CC: Cdc73/Paf1 complex, membrane, nucleoplasm, peroxisomal membrane, peroxisome
Pathways: Class I peroxisomal membrane protein import, E3 ubiquitin ligases ubiquitinate target proteins, Metabolism of proteins, Peroxisomal protein import, Peroxisome - Mus musculus (mouse), Post-translational protein modification, Protein localization, Protein ubiquitination
UniProt: P55098
Entrez ID: 19302
|
Does Knockout of Kcnk6 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Kcnk6
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Kcnk6 (potassium inwardly-rectifying channel, subfamily K, member 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: monoatomic ion transmembrane transport, monoatomic ion transport, negative regulation of systemic arterial blood pressure, positive regulation of NLRP3 inflammasome complex assembly, potassium ion transmembrane transport, potassium ion transport, regulation of lysosome size, regulation of resting membrane potential, regulation of systemic arterial blood pressure; MF: metal ion binding, outward rectifier potassium channel activity, potassium channel activity, potassium ion leak channel activity; CC: endosome, late endosome membrane, lysosomal membrane, lysosome, membrane, plasma membrane
Pathways: Cardiac conduction, Muscle contraction, Neuronal System, Phase 4 - resting membrane potential, Potassium Channels, Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK), Tandem pore domain potassium channels
UniProt: Q3TBV4
Entrez ID: 52150
|
Does Knockout of Pick1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Pick1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Pick1 (protein interacting with C kinase 1)
Type: protein-coding
Summary: Enables protein kinase C binding activity and signaling receptor binding activity. Involved in receptor clustering. Acts upstream of or within protein targeting. Located in several cellular components, including Golgi apparatus; perinuclear region of cytoplasm; and postsynaptic density. Is expressed in brain; cerebellum Purkinje cell layer; cerebellum molecular layer; cerebral cortex ventricular layer; and cortical plate. Orthologous to human PICK1 (protein interacting with PRKCA 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cellular response to decreased oxygen levels, cellular response to glucose starvation, dendritic spine maintenance, dendritic spine organization, glial cell development, intracellular protein transport, intracellular signal transduction, long-term synaptic depression, monoamine transport, negative regulation of Arp2/3 complex-mediated actin nucleation, negative regulation of gene expression, positive regulation of receptor internalization, protein phosphorylation, protein targeting, receptor clustering, regulation of Arp2/3 complex-mediated actin nucleation, regulation of insulin secretion, regulation of postsynaptic neurotransmitter receptor internalization, regulation of synapse structure or activity; MF: Arp2/3 complex binding, G protein-coupled glutamate receptor binding, G protein-coupled receptor binding, SNAP receptor activity, actin binding, actin filament binding, cytoskeletal protein binding, identical protein binding, ionotropic glutamate receptor binding, membrane curvature sensor activity, metal ion binding, phospholipid binding, protein binding, protein domain specific binding, protein kinase C binding, signaling receptor binding; CC: Golgi apparatus, cytoplasm, cytoskeleton, cytosol, dendrite, dendritic spine, excitatory synapse, glutamatergic synapse, membrane, mitochondrion, neuron projection, perinuclear region of cytoplasm, plasma membrane, postsynaptic density, postsynaptic endocytic zone, postsynaptic specialization, presynaptic membrane, protein-containing complex, synapse, synaptic vesicle, trans-Golgi network membrane
Pathways:
UniProt: Q8C1W2, E9PUZ5
Entrez ID: 18693
|
Does Knockout of Slc30a5 in Neuroblastoma Cell Line causally result in response to virus?
| 0
| 1,422
|
Knockout
|
Slc30a5
|
response to virus
|
Neuroblastoma Cell Line
|
Gene: Slc30a5 (solute carrier family 30 (zinc transporter), member 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: GPI anchor biosynthetic process, cobalt ion transport, insulin processing, intracellular zinc ion homeostasis, monoatomic cation transport, monoatomic ion transport, response to zinc ion, transmembrane transport, zinc ion import across plasma membrane, zinc ion import into Golgi lumen, zinc ion import into organelle, zinc ion transport; MF: antiporter activity, metal ion binding, monoatomic cation transmembrane transporter activity, zinc efflux transmembrane transporter activity, zinc ion transmembrane transporter activity, zinc:proton antiporter activity; CC: ER to Golgi transport vesicle membrane, Golgi apparatus, Golgi cis cisterna membrane, Golgi cisterna membrane, Golgi membrane, apical plasma membrane, cytoplasmic vesicle, endoplasmic reticulum membrane, membrane, nucleolus, nucleoplasm, plasma membrane, secretory granule, secretory granule membrane, trans-Golgi network membrane, transport vesicle membrane
Pathways: Insulin processing, Metabolism of proteins, Metal ion SLC transporters, Peptide hormone metabolism, SLC-mediated transmembrane transport, Transport of small molecules, Zinc efflux and compartmentalization by the SLC30 family, Zinc transporters
UniProt: Q8R4H9
Entrez ID: 69048
|
Does Knockout of Pcgf6 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Pcgf6
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Pcgf6 (polycomb group ring finger 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin remodeling, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II; MF: metal ion binding, protein binding, protein domain specific binding, zinc ion binding; CC: PRC1 complex, PcG protein complex, nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription, Signaling pathways regulating pluripotency of stem cells - Mus musculus (mouse), Transcriptional Regulation by E2F6
UniProt: Q99NA9
Entrez ID: 71041
|
Does Knockout of Spata20 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,273
|
Knockout
|
Spata20
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Spata20 (spermatogenesis associated 20)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: carbohydrate metabolic process, cell differentiation, spermatogenesis
Pathways:
UniProt: Q80YT5
Entrez ID: 217116
|
Does Knockout of Sirt6 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Sirt6
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Sirt6 (sirtuin 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, DNA repair-dependent chromatin remodeling, Ras protein signal transduction, base-excision repair, cardiac muscle cell differentiation, cellular response to angiotensin, cellular response to endothelin, cellular response to hydrogen peroxide, chromatin organization, chromatin remodeling, circadian regulation of gene expression, determination of adult lifespan, double-strand break repair, gluconeogenesis, glucose homeostasis, glycolytic process, inflammatory response, ketone biosynthetic process, negative regulation of D-glucose import, negative regulation of DNA-templated transcription, negative regulation of cell population proliferation, negative regulation of cellular senescence, negative regulation of gene expression, epigenetic, negative regulation of gluconeogenesis, negative regulation of glycolytic process, negative regulation of protein import into nucleus, negative regulation of protein localization to chromatin, negative regulation of transcription by RNA polymerase II, negative regulation of transcription elongation by RNA polymerase II, pericentric heterochromatin formation, positive regulation of blood vessel branching, positive regulation of cellular senescence, positive regulation of chondrocyte proliferation, positive regulation of cold-induced thermogenesis, positive regulation of double-strand break repair, positive regulation of fat cell differentiation, positive regulation of fibroblast proliferation, positive regulation of gluconeogenesis, positive regulation of insulin secretion, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of protein export from nucleus, positive regulation of protein localization to chromatin, positive regulation of stem cell differentiation, positive regulation of stem cell population maintenance, positive regulation of stem cell proliferation, positive regulation of telomere maintenance, positive regulation of transcription by RNA polymerase II, positive regulation of vascular endothelial cell proliferation, post-embryonic cardiac muscle cell growth involved in heart morphogenesis, protein deacetylation, protein delipidation, protein destabilization, protein import into nucleus, protein localization to site of double-strand break, protein poly-ADP-ribosylation, regulation of circadian rhythm, regulation of double-strand break repair via homologous recombination, regulation of lipid catabolic process, regulation of lipid metabolic process, regulation of protein export from nucleus, regulation of protein localization to plasma membrane, regulation of protein secretion, response to UV, response to nutrient levels, subtelomeric heterochromatin formation, transcription pausing by RNA polymerase II, transposable element silencing; MF: DNA binding, DNA damage sensor activity, NAD+ binding, NAD+-protein mono-ADP-ribosyltransferase activity, NAD+-protein-arginine ADP-ribosyltransferase activity, NAD+-protein-lysine ADP-ribosyltransferase activity, NAD-dependent protein demyristoylase activity, NAD-dependent protein depalmitoylase activity, NAD-dependent protein lysine deacetylase activity, RNA binding, TORC2 complex binding, acyltransferase activity, chromatin DNA binding, chromatin binding, damaged DNA binding, enzyme regulator activity, glycosyltransferase activity, histone H3K18 deacetylase activity, NAD-dependent, histone H3K56 deacetylase activity, NAD-dependent, histone H3K9 deacetylase activity, NAD-dependent, histone H3K9 deacetylase activity, hydrolytic mechanism, histone deacetylase activity, NAD-dependent, histone deacetylase regulator activity, lncRNA binding, metal ion binding, nucleosome binding, nucleotidyltransferase activity, protein homodimerization activity, protein lysine deacetylase activity, transcription corepressor activity, transferase activity, zinc ion binding; CC: chromatin, chromosome, chromosome, subtelomeric region, chromosome, telomeric region, endoplasmic reticulum, nucleolus, nucleoplasm, nucleus, pericentric heterochromatin, site of DNA damage, site of double-strand break
Pathways: Central carbon metabolism in cancer - Mus musculus (mouse), DNA Double-Strand Break Repair, DNA Repair, HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homology Directed Repair, Nicotinate and nicotinamide metabolism - Mus musculus (mouse), Processing of DNA double-strand break ends, Thermogenesis - Mus musculus (mouse)
UniProt: P59941
Entrez ID: 50721
|
Does Knockout of Tmem97 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Tmem97
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Tmem97 (transmembrane protein 97)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cholesterol homeostasis, positive regulation of lipoprotein transport, positive regulation of wound healing, regulation of intracellular cholesterol transport, regulation of intracellular lipid transport; MF: cholesterol binding, molecular_function, oxysterol binding; CC: endoplasmic reticulum, lysosome, membrane, nuclear membrane, nucleus, plasma membrane, rough endoplasmic reticulum, rough endoplasmic reticulum membrane
Pathways:
UniProt: Q8VD00
Entrez ID: 69071
|
Does Knockout of Tbxas1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 167
|
Knockout
|
Tbxas1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Tbxas1 (thromboxane A synthase 1, platelet)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: fatty acid biosynthetic process, fatty acid metabolic process, icosanoid metabolic process, intracellular chloride ion homeostasis, lipid metabolic process, long-chain fatty acid biosynthetic process, positive regulation of vasoconstriction, prostaglandin biosynthetic process, prostaglandin metabolic process, prostanoid biosynthetic process, response to ethanol, response to fatty acid; MF: 12-hydroxyheptadecatrienoic acid synthase activity, heme binding, hydroperoxy icosatetraenoate dehydratase activity, iron ion binding, isomerase activity, lyase activity, metal ion binding, monooxygenase activity, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, thromboxane-A synthase activity; CC: cytosol, endoplasmic reticulum, endoplasmic reticulum lumen, endoplasmic reticulum membrane, membrane
Pathways: Arachidonate metabolism, Arachidonic acid metabolism - Mus musculus (mouse), Biological oxidations, Cytochrome P450 - arranged by substrate type, Eicosanoids, Fatty acid metabolism, Metabolism, Metabolism of lipids, Phase I - Functionalization of compounds, Platelet activation - Mus musculus (mouse), Synthesis of Prostaglandins (PG) and Thromboxanes (TX), biosynthesis of prostaglandins
UniProt: P36423
Entrez ID: 21391
|
Does Knockout of Usp18 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 2,176
|
Knockout
|
Usp18
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Usp18 (ubiquitin specific peptidase 18)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: antiviral innate immune response, negative regulation of type I interferon-mediated signaling pathway, protein deubiquitination, proteolysis, regulation of inflammatory response, regulation of protein stability, response to bacterium, response to other organism, response to stilbenoid; MF: ISG15-specific peptidase activity, cysteine-type deubiquitinase activity, cysteine-type peptidase activity, hydrolase activity, molecular adaptor activity, peptidase activity, protein binding; CC: cytosol, nucleus
Pathways: Antiviral mechanism by IFN-stimulated genes, Cytokine Signaling in Immune system, Deubiquitination, ISG15 antiviral mechanism, Immune System, Innate Immune System, Interferon Signaling, Interferon alpha/beta signaling, Interleukin-1 family signaling, Interleukin-1 signaling, Metabolism of proteins, MyD88 cascade initiated on plasma membrane, MyD88 dependent cascade initiated on endosome, MyD88-independent TLR4 cascade , MyD88:MAL(TIRAP) cascade initiated on plasma membrane, Post-translational protein modification, Regulation of IFNA/IFNB signaling, Regulation of NF-kappa B signaling, Signaling by Interleukins, TAK1-dependent IKK and NF-kappa-B activation , TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, TRIF (TICAM1)-mediated TLR4 signaling , Toll Like Receptor 10 (TLR10) Cascade, Toll Like Receptor 2 (TLR2) Cascade, Toll Like Receptor 3 (TLR3) Cascade, Toll Like Receptor 4 (TLR4) Cascade, Toll Like Receptor 5 (TLR5) Cascade, Toll Like Receptor 7/8 (TLR7/8) Cascade, Toll Like Receptor 9 (TLR9) Cascade, Toll Like Receptor TLR1:TLR2 Cascade, Toll Like Receptor TLR6:TLR2 Cascade, Toll-like Receptor Cascades, Ub-specific processing proteases
UniProt: Q9WTV6
Entrez ID: 24110
|
Does Knockout of Defb48 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
Defb48
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Defb48 (defensin beta 48)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell chemotaxis, defense response, defense response to bacterium, positive chemotaxis; MF: CCR6 chemokine receptor binding, chemoattractant activity; CC: extracellular region, extracellular space
Pathways: Antimicrobial peptides, Beta defensins, Defensins, Immune System, Innate Immune System
UniProt: Q3UW22
Entrez ID: 432867
|
Does Knockout of Abca3 in Regulatory T cell causally result in cell proliferation?
| 0
| 1,483
|
Knockout
|
Abca3
|
cell proliferation
|
Regulatory T cell
|
Gene: Abca3 (ATP-binding cassette, sub-family A member 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intermembrane lipid transfer, lipid translocation, lipid transport, lung development, organelle assembly, phosphatidylcholine metabolic process, phosphatidylglycerol metabolic process, phospholipid homeostasis, phospholipid transport, positive regulation of cholesterol efflux, positive regulation of phospholipid efflux, positive regulation of phospholipid transport, positive regulation of protein homooligomerization, regulation of lipid biosynthetic process, regulation of lipid transport, regulation of phosphatidylcholine metabolic process, response to glucocorticoid, surfactant homeostasis, transmembrane transport, xenobiotic export from cell, xenobiotic transmembrane transport, xenobiotic transport; MF: ABC-type transporter activity, ABC-type xenobiotic transporter activity, ATP binding, ATP hydrolysis activity, ATPase-coupled intramembrane lipid transporter activity, ATPase-coupled transmembrane transporter activity, lipid transporter activity, nucleotide binding, phosphatidylcholine flippase activity, phosphatidylcholine transfer activity; CC: alveolar lamellar body, alveolar lamellar body membrane, cytoplasm, cytoplasmic vesicle, cytoplasmic vesicle membrane, endomembrane system, endosome, intracellular membrane-bounded organelle, lamellar body, lamellar body membrane, late endosome, late endosome membrane, lysosomal membrane, lysosome, membrane, multivesicular body membrane, plasma membrane
Pathways: ABC transporters - Mus musculus (mouse), ABC transporters in lipid homeostasis, ABC-family proteins mediated transport, Metabolism of proteins, Surfactant metabolism, Transport of small molecules
UniProt: Q8R420
Entrez ID: 27410
|
Does Knockout of Unc5b in Mouse Embryonic Stem Cell causally result in protein/peptide accumulation?
| 0
| 1,077
|
Knockout
|
Unc5b
|
protein/peptide accumulation
|
Mouse Embryonic Stem Cell
|
Gene: Unc5b (unc-5 netrin receptor B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: angiogenesis, anterior/posterior axon guidance, apoptotic process, axon guidance, negative regulation of extrinsic apoptotic signaling pathway in absence of ligand, negative regulation of neuron apoptotic process, netrin-activated signaling pathway, positive regulation of extrinsic apoptotic signaling pathway in absence of ligand, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, signal transduction; MF: netrin receptor activity, protein binding; CC: cytosol, membrane, membrane raft, plasma membrane
Pathways: Axon guidance - Mus musculus (mouse)
UniProt: Q8K1S3
Entrez ID: 107449
|
Does Knockout of Sox13 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Sox13
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Sox13 (SRY (sex determining region Y)-box 13)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, cell fate commitment, gamma-delta T cell differentiation, negative regulation of DNA-templated transcription, negative regulation of canonical Wnt signaling pathway, negative regulation of transcription by RNA polymerase II, oligodendrocyte differentiation, positive regulation of brown fat cell differentiation, positive regulation of cell differentiation, positive regulation of gamma-delta T cell differentiation, regulation of DNA-templated transcription, regulation of gamma-delta T cell differentiation, regulation of transcription by RNA polymerase II, spinal cord oligodendrocyte cell differentiation; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, identical protein binding, protein binding, sequence-specific DNA binding, transcription cis-regulatory region binding; CC: cytoplasm, nucleoplasm, nucleus
Pathways: Deactivation of the beta-catenin transactivating complex, Signal Transduction, Signaling by WNT, TCF dependent signaling in response to WNT
UniProt: Q04891
Entrez ID: 20668
|
Does Knockout of Sgip1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Sgip1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Sgip1 (SH3-domain GRB2-like (endophilin) interacting protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: clathrin-dependent endocytosis, endocytosis, energy homeostasis, plasma membrane tubulation, positive regulation of eating behavior, positive regulation of feeding behavior, positive regulation of multicellular organism growth, positive regulation of receptor-mediated endocytosis, response to dietary excess, synaptic vesicle endocytosis; MF: SH3 domain binding, microtubule binding, phospholipid binding, protein binding, tubulin binding; CC: AP-2 adaptor complex, clathrin-coated pit, clathrin-coated vesicle, cytoplasm, membrane, plasma membrane, presynapse
Pathways:
UniProt: Q8VD37
Entrez ID: 73094
|
Does Knockout of Gm10840 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,282
|
Knockout
|
Gm10840
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Gm10840 (predicted gene 10840)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID:
|
Does Knockout of Uqcr10 in macrophage causally result in response to bacteria?
| 0
| 2,211
|
Knockout
|
Uqcr10
|
response to bacteria
|
macrophage
|
Gene: Uqcr10 (ubiquinol-cytochrome c reductase, complex III subunit X)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular respiration, mitochondrial electron transport, ubiquinol to cytochrome c; CC: membrane, mitochondrial inner membrane, mitochondrion, respiratory chain complex III
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Cardiac muscle contraction - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Complex III assembly, Diabetic cardiomyopathy - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Metabolism, Non-alcoholic fatty liver disease - Mus musculus (mouse), Oxidative phosphorylation - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Respiratory electron transport, Thermogenesis - Mus musculus (mouse), aerobic respiration -- electron donor II
UniProt: Q8R1I1
Entrez ID: 66152
|
Does Knockout of Gm5797 in Immortal mouse chromaffin cells causally result in cell viability?
| 0
| 2,469
|
Knockout
|
Gm5797
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Gm5797 (predicted gene 5797)
Type: protein-coding
Summary: predicted gene 5797
Gene Ontology:
Pathways:
UniProt: Q5BKP9
Entrez ID: 545013
|
Does Knockout of Rsbn1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,683
|
Knockout
|
Rsbn1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Rsbn1 (rosbin, round spermatid basic protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, chromatin organization, chromatin remodeling; MF: dioxygenase activity, histone H4K20 demethylase activity, metal ion binding, oxidoreductase activity, protein binding; CC: nucleus
Pathways:
UniProt: Q80T69
Entrez ID: 229675
|
Does Knockout of Nedd4l in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 163
|
Knockout
|
Nedd4l
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Nedd4l (neural precursor cell expressed, developmentally down-regulated gene 4-like)
Type: protein-coding
Summary: Enables sodium channel inhibitor activity and ubiquitin protein ligase activity. Involved in regulation of postsynaptic neurotransmitter receptor internalization; regulation protein catabolic process at postsynapse; and ubiquitin-dependent protein catabolic process. Acts upstream of or within several processes, including negative regulation of systemic arterial blood pressure; regulation of bicellular tight junction assembly; and regulation of monoatomic ion transport. Is active in glutamatergic synapse. Is expressed in several structures, including central nervous system; genitourinary system; gut; limb segment; and retina. Human ortholog(s) of this gene implicated in periventricular nodular heterotopia. Orthologous to human NEDD4L (NEDD4 like E3 ubiquitin protein ligase). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cell differentiation, establishment of localization in cell, monoatomic ion transport, negative regulation of potassium ion export across plasma membrane, negative regulation of potassium ion transmembrane transport, negative regulation of protein localization to cell surface, negative regulation of sodium ion import across plasma membrane, negative regulation of sodium ion transmembrane transport, negative regulation of sodium ion transport, negative regulation of systemic arterial blood pressure, neuromuscular junction development, neuron projection development, positive regulation of caveolin-mediated endocytosis, positive regulation of dendrite extension, positive regulation of protein catabolic process, positive regulation of sodium ion transport, proteasome-mediated ubiquitin-dependent protein catabolic process, protein K48-linked ubiquitination, protein monoubiquitination, protein ubiquitination, receptor catabolic process, receptor internalization, regulation of bicellular tight junction assembly, regulation of biological quality, regulation of dendrite morphogenesis, regulation of membrane depolarization, regulation of membrane potential, regulation of membrane repolarization, regulation of postsynaptic neurotransmitter receptor internalization, regulation of protein stability, regulation of sodium ion transmembrane transport, regulation of sodium ion transport, regulation of synapse organization, regulation protein catabolic process at postsynapse, response to salt stress, sodium ion import across plasma membrane, ubiquitin-dependent protein catabolic process, ventricular cardiac muscle cell action potential; MF: potassium channel inhibitor activity, protein binding, sodium channel inhibitor activity, sodium channel regulator activity, transferase activity, transmembrane transporter binding, ubiquitin protein ligase activity, ubiquitin-protein transferase activity; CC: Golgi apparatus, apical plasma membrane, cytoplasm, endosome, glutamatergic synapse, multivesicular body, plasma membrane, postsynapse
Pathways: Aldosterone-regulated sodium reabsorption - Mus musculus (mouse), Endocytosis - Mus musculus (mouse), Tight junction - Mus musculus (mouse), Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: Q8CFI0
Entrez ID: 83814
|
Does Knockout of Cacna1c in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,488
|
Knockout
|
Cacna1c
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Cacna1c (calcium channel, voltage-dependent, L type, alpha 1C subunit)
Type: protein-coding
Summary: Enables enzyme binding activity and voltage-gated calcium channel activity involved in cardiac muscle cell action potential. Involved in positive regulation of adenylate cyclase activity. Acts upstream of or within several processes, including adult walking behavior; regulation of blood circulation; and secretion by cell. Located in several cellular components, including T-tubule; Z disc; and dendritic shaft. Part of caveolar macromolecular signaling complex and voltage-gated calcium channel complex. Is expressed in several structures, including central nervous system; eye; genitourinary system; gut; and heart. Used to study Timothy syndrome. Human ortholog(s) of this gene implicated in Brugada syndrome 3; Timothy syndrome; long QT syndrome 8; and neurodevelopmental disorder with hypotonia, language delay, and skeletal defects with or without seizures. Orthologous to human CACNA1C (calcium voltage-gated channel subunit alpha1 C). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: adult walking behavior, calcium ion import, calcium ion import across plasma membrane, calcium ion transmembrane import into cytosol, calcium ion transmembrane transport, calcium ion transmembrane transport via high voltage-gated calcium channel, calcium ion transport, calcium ion transport into cytosol, calcium-ion regulated exocytosis, camera-type eye development, cardiac conduction, cardiac muscle cell action potential involved in contraction, cell communication, cell communication involved in cardiac conduction, chemical synaptic transmission, embryonic forelimb morphogenesis, establishment of localization in cell, exocytosis, glucose homeostasis, growth hormone secretion, heart development, immune system development, insulin secretion, intracellular calcium ion homeostasis, membrane depolarization during AV node cell action potential, membrane depolarization during atrial cardiac muscle cell action potential, membrane depolarization during cardiac muscle cell action potential, monoatomic ion transmembrane transport, monoatomic ion transport, positive regulation of adenylate cyclase activity, positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel, positive regulation of cytosolic calcium ion concentration, positive regulation of insulin secretion, positive regulation of membrane depolarization, positive regulation of muscle contraction, regulation of blood pressure, regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion, regulation of heart contraction, regulation of heart rate by cardiac conduction, regulation of membrane potential, regulation of organ growth, regulation of vasoconstriction, regulation of ventricular cardiac muscle cell action potential, signaling, smooth muscle contraction, smooth muscle contraction involved in micturition, system process, transmembrane transport, visual learning; MF: alpha-actinin binding, calcium channel activity, calmodulin binding, enzyme binding, high voltage-gated calcium channel activity, metal ion binding, monoatomic ion channel activity, protein binding, protein domain specific binding, protein phosphatase 2A binding, translation initiation factor binding, transmembrane transporter binding, voltage-gated calcium channel activity, voltage-gated calcium channel activity involved in AV node cell action potential, voltage-gated calcium channel activity involved in cardiac muscle cell action potential; CC: L-type voltage-gated calcium channel complex, T-tubule, Z disc, axon, caveolar macromolecular signaling complex, cell projection, cell surface, cilium, cytoplasm, dendrite, dendritic shaft, glutamatergic synapse, membrane, monoatomic ion channel complex, neuronal cell body, nucleoplasm, perikaryon, plasma membrane, plasma membrane protein complex, postsynaptic density, postsynaptic density membrane, postsynaptic membrane, presynaptic membrane, protein-containing complex, sarcolemma, synapse, transmembrane transporter complex, voltage-gated calcium channel complex
Pathways: Adrenergic signaling in cardiomyocytes - Mus musculus (mouse), Aldosterone synthesis and secretion - Mus musculus (mouse), Alzheimer disease - Mus musculus (mouse), Amphetamine addiction - Mus musculus (mouse), Arrhythmogenic right ventricular cardiomyopathy - Mus musculus (mouse), Calcium signaling pathway - Mus musculus (mouse), Cardiac conduction, Cardiac muscle contraction - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Cholinergic synapse - Mus musculus (mouse), Circadian entrainment - Mus musculus (mouse), Cortisol synthesis and secretion - Mus musculus (mouse), Cushing syndrome - Mus musculus (mouse), Dilated cardiomyopathy - Mus musculus (mouse), Dopaminergic synapse - Mus musculus (mouse), GABAergic synapse - Mus musculus (mouse), Glutamatergic synapse - Mus musculus (mouse), GnRH secretion - Mus musculus (mouse), GnRH signaling pathway - Mus musculus (mouse), Growth hormone synthesis, secretion and action - Mus musculus (mouse), Hypertrophic cardiomyopathy - Mus musculus (mouse), Insulin secretion - Mus musculus (mouse), Integration of energy metabolism, Long-term potentiation - Mus musculus (mouse), MAPK signaling pathway - Mus musculus (mouse), Metabolism, Muscle contraction, Oxytocin signaling pathway - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Phase 0 - rapid depolarisation, Phase 2 - plateau phase, Prion disease - Mus musculus (mouse), Regulation of insulin secretion, Renin secretion - Mus musculus (mouse), Retrograde endocannabinoid signaling - Mus musculus (mouse), Serotonergic synapse - Mus musculus (mouse), Taste transduction - Mus musculus (mouse), Type II diabetes mellitus - Mus musculus (mouse), Vascular smooth muscle contraction - Mus musculus (mouse), cAMP signaling pathway - Mus musculus (mouse), cGMP-PKG signaling pathway - Mus musculus (mouse)
UniProt: Q01815
Entrez ID: 12288
|
Does Knockout of Vmn2r45 in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Vmn2r45
|
cell cycle progression
|
breast epithelium
|
Gene: Vmn2r45 (vomeronasal 2, receptor 45)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, signal transduction; MF: G protein-coupled receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: L7N2B5
Entrez ID: 100042810
|
Does Knockout of Ppy in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,680
|
Knockout
|
Ppy
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Ppy (pancreatic polypeptide)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: feeding behavior, neuropeptide signaling pathway; MF: G protein-coupled receptor binding, hormone activity, neuropeptide Y receptor binding, neuropeptide hormone activity; CC: cytoplasm, extracellular region, extracellular space
Pathways: Class A/1 (Rhodopsin-like receptors), G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Peptide ligand-binding receptors, Signal Transduction, Signaling by GPCR
UniProt: P10601
Entrez ID: 19064
|
Does Knockout of Ntrk1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Ntrk1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Ntrk1 (neurotrophic tyrosine kinase, receptor, type 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell differentiation, Sertoli cell development, axon guidance, axonogenesis involved in innervation, behavioral response to formalin induced pain, cell differentiation, cell surface receptor protein tyrosine kinase signaling pathway, cellular response to growth factor stimulus, cellular response to nerve growth factor stimulus, cellular response to nicotine, circadian rhythm, detection of mechanical stimulus involved in sensory perception of pain, detection of temperature stimulus involved in sensory perception of pain, ephrin receptor signaling pathway, innervation, learning or memory, mechanoreceptor differentiation, negative regulation of cell population proliferation, negative regulation of neuron apoptotic process, nerve development, nerve growth factor signaling pathway, nervous system development, neuron development, neuron projection development, neurotrophin TRK receptor signaling pathway, olfactory nerve development, peptidyl-tyrosine autophosphorylation, peptidyl-tyrosine phosphorylation, positive regulation of ERK1 and ERK2 cascade, positive regulation of GTPase activity, positive regulation of NF-kappaB transcription factor activity, positive regulation of Ras protein signal transduction, positive regulation of angiogenesis, positive regulation of neuron projection development, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of programmed cell death, positive regulation of synapse assembly, positive regulation of synaptic transmission, glutamatergic, programmed cell death, programmed cell death involved in cell development, protein autophosphorylation, response to activity, response to axon injury, response to electrical stimulus, response to hydrostatic pressure, response to nicotine, response to nutrient levels, response to xenobiotic stimulus, spermatogenesis, sympathetic nervous system development; MF: ATP binding, GPI-linked ephrin receptor activity, identical protein binding, kinase activity, kinase binding, nerve growth factor binding, nerve growth factor receptor activity, neurotrophin binding, neurotrophin p75 receptor binding, neurotrophin receptor activity, nucleotide binding, protein binding, protein homodimerization activity, protein kinase activity, protein tyrosine kinase activity, transferase activity, transmembrane receptor protein tyrosine kinase activity; CC: axon, cell surface, cytoplasm, dendrite, early endosome, early endosome membrane, endosome, late endosome, late endosome membrane, membrane, mitochondrion, neuronal cell body, plasma membrane, protein-containing complex, receptor complex, recycling endosome, recycling endosome membrane
Pathways: ARMS-mediated activation, Activation of TRKA receptors, Apoptosis - Mus musculus (mouse), Calcium signaling pathway - Mus musculus (mouse), Central carbon metabolism in cancer - Mus musculus (mouse), Frs2-mediated activation, Inflammatory mediator regulation of TRP channels - Mus musculus (mouse), MAPK signaling pathway - Mus musculus (mouse), Neurotrophin signaling pathway - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), PI3K/AKT activation, Pathways in cancer - Mus musculus (mouse), Prolonged ERK activation events, Ras signaling pathway - Mus musculus (mouse), Retrograde neurotrophin signalling, Signal Transduction, Signaling by NTRK1 (TRKA), Signaling by NTRKs, Signaling by Receptor Tyrosine Kinases, Signalling to ERKs, TRKA activation by NGF, Thyroid cancer - Mus musculus (mouse), Transcriptional misregulation in cancer - Mus musculus (mouse)
UniProt: Q3UFB7
Entrez ID: 18211
|
Does Knockout of Ighv1-12 in macrophage causally result in phagocytosis?
| 0
| 1,890
|
Knockout
|
Ighv1-12
|
phagocytosis
|
macrophage
|
Gene: Ighv1-12 (immunoglobulin heavy variable V1-12)
Type: other
Summary: No summary available.
Gene Ontology: BP: adaptive immune response, immune system process, immunoglobulin mediated immune response; CC: extracellular region, immunoglobulin complex
Pathways:
UniProt:
Entrez ID: 629860
|
Does Knockout of Hsd3b7 in Mouse Embryonic Stem Cell causally result in protein/peptide accumulation?
| 0
| 1,077
|
Knockout
|
Hsd3b7
|
protein/peptide accumulation
|
Mouse Embryonic Stem Cell
|
Gene: Hsd3b7 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell chemotaxis, cholesterol catabolic process, lipid metabolic process, regulation of cell growth, steroid biosynthetic process; MF: cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity, oxidoreductase activity, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; CC: endoplasmic reticulum, endoplasmic reticulum membrane, lipid droplet, membrane
Pathways: Bile acid and bile salt metabolism, Metabolism, Metabolism of lipids, Metabolism of steroids, Primary bile acid biosynthesis - Mus musculus (mouse), Synthesis of bile acids and bile salts, Synthesis of bile acids and bile salts via 24-hydroxycholesterol, Synthesis of bile acids and bile salts via 27-hydroxycholesterol, Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
UniProt: Q9EQC1
Entrez ID: 101502
|
Does Knockout of Pou2f1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Pou2f1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Pou2f1 (POU domain, class 2, transcription factor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: lens induction in camera-type eye, negative regulation of DNA-templated transcription, negative regulation of miRNA transcription, olfactory placode formation, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II core promoter sequence-specific DNA binding, chromatin binding, identical protein binding, protein binding, sequence-specific DNA binding, signaling receptor binding, transcription cis-regulatory region binding; CC: RNA polymerase II transcription regulator complex, endoplasmic reticulum, nucleoplasm, nucleus, transcription regulator complex
Pathways: Gene expression (Transcription), Herpes simplex virus 1 infection - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), RNA Polymerase II Transcription, RNA Polymerase III Transcription, RNA Polymerase III Transcription Initiation, RNA Polymerase III Transcription Initiation From Type 3 Promoter, RNA polymerase II transcribes snRNA genes
UniProt: P25425
Entrez ID: 18986
|
Does Knockout of Akr1c19 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Akr1c19
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Akr1c19 (aldo-keto reductase family 1, member C19)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: daunorubicin metabolic process, doxorubicin metabolic process, progesterone metabolic process, prostaglandin metabolic process; MF: 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity, 3-alpha-hydroxysteroid 3-dehydrogenase [NAD(P)+] activity, Delta4-3-oxosteroid 5beta-reductase activity, alcohol dehydrogenase (NADP+) activity, aldose reductase (NADPH) activity, all-trans-retinol dehydrogenase (NAD+) activity, androsterone dehydrogenase [NAD(P)+] activity, bile acid binding, carboxylic acid binding, chlordecone reductase activity, geranylgeranyl reductase activity, ketoreductase activity, ketosteroid monooxygenase activity, oxidoreductase activity, oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor, prostaglandin D2 11-ketoreductase activity, prostaglandin H2 endoperoxidase reductase activity, retinal dehydrogenase (NAD+) activity, trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity; CC: cytoplasm, cytosol, nucleus
Pathways:
UniProt: A0A1Y7VK17, G3X9Y6
Entrez ID: 432720
|
Does Knockout of Oscar in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Oscar
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Oscar (osteoclast associated receptor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Fc-gamma receptor signaling pathway, collagen-activated signaling pathway, immune response-regulating signaling pathway, multinuclear osteoclast differentiation, osteoclast differentiation, positive regulation of bone resorption; MF: collagen receptor activity, protein binding; CC: cell surface, membrane, plasma membrane
Pathways: Adaptive Immune System, Immune System, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, Innate Immune System, Neutrophil degranulation, Osteoclast differentiation - Mus musculus (mouse)
UniProt: Q8VBT3
Entrez ID: 232790
|
Does Knockout of Kcnk7 in macrophage causally result in phagocytosis?
| 0
| 1,890
|
Knockout
|
Kcnk7
|
phagocytosis
|
macrophage
|
Gene: Kcnk7 (potassium channel, subfamily K, member 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: monoatomic ion transmembrane transport, monoatomic ion transport, potassium ion transmembrane transport, potassium ion transport; MF: outward rectifier potassium channel activity, potassium channel activity, potassium ion leak channel activity; CC: membrane, monoatomic ion channel complex, plasma membrane
Pathways: Cardiac conduction, Muscle contraction, Neuronal System, Phase 4 - resting membrane potential, Potassium Channels, Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK), Tandem pore domain potassium channels
UniProt: Q9Z2T1
Entrez ID: 16530
|
Does Knockout of Sash3 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Sash3
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Sash3 (SAM and SH3 domain containing 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell homeostasis, homeostasis of number of cells within a tissue, positive regulation of B cell proliferation, positive regulation of CD4-positive, alpha-beta T cell differentiation, positive regulation of T cell cytokine production, positive regulation of T cell proliferation, positive regulation of adaptive immune response, positive regulation of immunoglobulin production, positive regulation of interleukin-10 production, positive regulation of interleukin-2 production, positive regulation of interleukin-4 production, positive regulation of lymphocyte activation, positive regulation of organ growth, positive regulation of tumor necrosis factor production, positive regulation of type II interferon production, regulation of intracellular signal transduction; CC: cytoplasm, nucleus
Pathways:
UniProt: Q8K352
Entrez ID: 74131
|
Does Knockout of Grin1os in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Grin1os
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Grin1os (glutamate receptor, ionotropic, NMDA1 (zeta 1), opposite strand)
Type: ncRNA
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 320354
|
Does Knockout of Pcbp4 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
Pcbp4
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Pcbp4 (poly(rC) binding protein 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of DNA damage response, signal transduction by p53 class mediator, negative regulation of mRNA splicing, via spliceosome, regulation of gene expression, regulation of mRNA metabolic process, regulation of mRNA stability, regulation of transcription by RNA polymerase II; MF: DNA binding, RNA binding, mRNA 3'-UTR binding, mRNA binding, nucleic acid binding; CC: cytoplasm, cytosol, nucleus, ribonucleoprotein complex
Pathways:
UniProt: P57724
Entrez ID: 59092
|
Does Knockout of Ndufc1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Ndufc1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Ndufc1 (NADH:ubiquinone oxidoreductase subunit C1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: aerobic respiration, proton motive force-driven mitochondrial ATP synthesis; CC: membrane, mitochondrial inner membrane, mitochondrion, respiratory chain complex I
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Complex I biogenesis, Diabetic cardiomyopathy - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Metabolism, NADH to cytochrome <i>bd</i> oxidase electron transfer I, NADH to cytochrome <i>bo</i> oxidase electron transfer I, Non-alcoholic fatty liver disease - Mus musculus (mouse), Oxidative phosphorylation - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Respiratory electron transport, Retrograde endocannabinoid signaling - Mus musculus (mouse), Thermogenesis - Mus musculus (mouse), aerobic respiration -- electron donor II
UniProt: Q9CQY9
Entrez ID: 66377
|
Does Knockout of Cep72 in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Cep72
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Cep72 (centrosomal protein 72)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: centriole replication, gamma-tubulin complex localization, regulation of protein localization to centrosome, spindle organization; CC: centriolar satellite, centrosome, ciliary basal body, cytoplasm, cytoskeleton, cytosol
Pathways: AURKA Activation by TPX2, Anchoring of the basal body to the plasma membrane, Cell Cycle, Cell Cycle, Mitotic, Centrosome maturation, Cilium Assembly, G2/M Transition, Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, Mitotic G2-G2/M phases, Mitotic Prometaphase, Organelle biogenesis and maintenance, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Regulation of PLK1 Activity at G2/M Transition
UniProt: Q9D3R3
Entrez ID: 74470
|
Does Knockout of Agbl2 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,565
|
Knockout
|
Agbl2
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Agbl2 (ATP/GTP binding protein-like 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein side chain deglutamylation, proteolysis; MF: carboxypeptidase activity, hydrolase activity, metal ion binding, metallocarboxypeptidase activity, metallopeptidase activity, peptidase activity, tubulin binding, zinc ion binding; CC: cell projection, centriole, ciliary basal body, cytoplasm, cytoskeleton, cytosol, microtubule cytoskeleton
Pathways:
UniProt: Q8CDK2
Entrez ID: 271813
|
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