prompt string | hit int64 | screen_id int64 | crispr_strategy string | gene string | phenotype string | cell_type string | gene_context string |
|---|---|---|---|---|---|---|---|
Does Knockout of Bsdc1 in Pancreatic Cancer Cell Line causally result in response to chemicals? | 0 | 2,359 | Knockout | Bsdc1 | response to chemicals | Pancreatic Cancer Cell Line | Gene: Bsdc1 (BSD domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q80Y55
Entrez ID: 100383 |
Does Knockout of Glyctk in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,287 | Knockout | Glyctk | cell proliferation | Mouse kidney carcinoma cell | Gene: Glyctk (glycerate kinase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: fructose catabolic process, protein phosphorylation; MF: ATP binding, glycerate kinase activity, kinase activity, nucleotide binding, transferase activity; CC: Golgi apparatus, cytoplasm, cyto... |
Does Knockout of Scarb1 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity? | 0 | 2,172 | Knockout | Scarb1 | tumorigenicity | Breast Adenocarcinoma Cell Line | Gene: Scarb1 (scavenger receptor class B, member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adhesion of symbiont to host, androgen biosynthetic process, blood vessel endothelial cell migration, cholesterol catabolic process, cholesterol efflux, cholesterol homeost... |
Does Knockout of Plk2 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity? | 0 | 1,664 | Knockout | Plk2 | tumorigenicity | Breast Adenocarcinoma Cell Line | Gene: Plk2 (polo like kinase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G1/S transition of mitotic cell cycle, Rap protein signal transduction, Ras protein signal transduction, long-term synaptic depression, long-term synaptic potentiation, memory, mitotic cell cy... |
Does Knockout of Bsn in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,287 | Knockout | Bsn | cell proliferation | Mouse kidney carcinoma cell | Gene: Bsn (bassoon)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: axo-dendritic transport, maintenance of presynaptic active zone structure, modulation of chemical synaptic transmission, presynaptic active zone assembly, presynaptic active zone organization, protein loc... |
Does Knockout of Mmachc in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 1,273 | Knockout | Mmachc | cell proliferation | Mammary Gland Tumor Cell Line | Gene: Mmachc (methylmalonic aciduria cblC type, with homocystinuria)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cobalamin metabolic process, demethylation, glutathione metabolic process; MF: FAD binding, cobalamin binding, cyanocobalamin reductase (cyanide-eliminatin... |
Does Knockout of Mir466b-3 in breast epithelium causally result in cell cycle progression? | 0 | 1,469 | Knockout | Mir466b-3 | cell cycle progression | breast epithelium | Gene: Mir466b-3 (microRNA 466b-3)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polyme... |
Does Knockout of Hectd3 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 0 | 1,130 | Knockout | Hectd3 | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Hectd3 (HECT domain E3 ubiquitin protein ligase 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: proteasome-mediated ubiquitin-dependent protein catabolic process, protein ubiquitination; MF: syntaxin binding, transferase activity, ubiquitin protein ligase activit... |
Does Knockout of Zmiz2 in Melanoma Cell Line causally result in cell proliferation? | 0 | 1,269 | Knockout | Zmiz2 | cell proliferation | Melanoma Cell Line | Gene: Zmiz2 (zinc finger, MIZ-type containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of transcription by RNA polymerase II, protein sumoylation, regulation of transcription by RNA polymerase II; MF: SUMO ligase activity, metal ion binding, ... |
Does Knockout of Slc35f2 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 0 | 161 | Knockout | Slc35f2 | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Slc35f2 (solute carrier family 35, member F2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, transmembrane transport; MF: molecular_function, transmembrane transporter activity; CC: cellular_component, membrane
Pathways:
UniPr... |
Does Knockout of Cfdp1 in macrophage causally result in phagocytosis? | 0 | 1,890 | Knockout | Cfdp1 | phagocytosis | macrophage | Gene: Cfdp1 (craniofacial development protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, chromatin remodeling, negative regulation of fibroblast apoptotic process, regulation of cell population proliferation, regulation of cell shape; CC: Swr1 compl... |
Does Knockout of Tmem269 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 0 | 82 | Knockout | Tmem269 | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Tmem269 (transmembrane protein 269)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q9D4Y8
Entrez ID: 75180 |
Does Knockout of Glp1r in Colonic Cancer Cell Line causally result in tumorigenicity? | 0 | 2,178 | Knockout | Glp1r | tumorigenicity | Colonic Cancer Cell Line | Gene: Glp1r (glucagon-like peptide 1 receptor)
Type: protein-coding
Summary: Predicted to enable glucagon receptor activity; glucagon-like peptide 1 receptor activity; and peptide hormone binding activity. Involved in several processes, including learning or memory; positive regulation of blood pressure... |
Does Knockout of Coq10a in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,263 | Knockout | Coq10a | cell proliferation | Colonic Cancer Cell Line | Gene: Coq10a (coenzyme Q10A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: mitochondrial inner membrane, mitochondrial membrane, mitochondrion
Pathways: Aerobic respiration and respiratory electron transport, Complex IV assembly, Metabolism, Respiratory electro... |
Does Knockout of Xpot in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,683 | Knockout | Xpot | protein/peptide distribution | myoblast cell line | Gene: Xpot (exportin, tRNA (nuclear export receptor for tRNAs))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intracellular protein transport, nucleocytoplasmic transport, tRNA export from nucleus, tRNA re-export from nucleus; MF: RNA binding, small GTPase binding, tRNA... |
Does Knockout of Cdrt4 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,681 | Knockout | Cdrt4 | protein/peptide distribution | myoblast cell line | Gene: Cdrt4 (CMT1A duplicated region transcript 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q9DA64
Entrez ID: 66338 |
Does Knockout of Angpt1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 0 | 82 | Knockout | Angpt1 | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Angpt1 (angiopoietin 1)
Type: protein-coding
Summary: This gene encodes a secreted glycoprotein that belongs to the angiopoietin family of vascular growth factors. The encoded protein is a ligand in the vascular tyrosine kinase signaling pathway and regulates the formation and stabilization of blo... |
Does Knockout of Ppp3cc in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,684 | Knockout | Ppp3cc | protein/peptide distribution | myoblast cell line | Gene: Ppp3cc (protein phosphatase 3, catalytic subunit, gamma isoform)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: calcineurin-NFAT signaling cascade, calcineurin-mediated signaling, negative regulation of calcium ion import across plasma membrane, penetration of zona... |
Does Knockout of Ssr3 in macrophage causally result in phagocytosis? | 0 | 1,890 | Knockout | Ssr3 | phagocytosis | macrophage | Gene: Ssr3 (signal sequence receptor, gamma)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Protein processing in endoplasmic reticulum - Mus musculus (mouse)
UniProt: Q9DCF9
... |
Does Knockout of Slf2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 1 | 83 | Knockout | Slf2 | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Slf2 (SMC5-SMC6 complex localization factor 2)
Type: protein-coding
Summary: Predicted to enable ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including positive regulation of cellular component organization; positive regulation of double-strand break re... |
Does Knockout of Uso1 in macrophage causally result in phagocytosis? | 0 | 1,888 | Knockout | Uso1 | phagocytosis | macrophage | Gene: Uso1 (USO1 vesicle docking factor)
Type: protein-coding
Summary: Acts upstream of or within several processes, including Golgi organization; regulation of cellular response to insulin stimulus; and small GTPase-mediated signal transduction. Located in cytosol and perinuclear region of cytoplasm. I... |
Does Knockout of Rplp0 in Microglial Cell Line causally result in protein/peptide accumulation? | 0 | 1,399 | Knockout | Rplp0 | protein/peptide accumulation | Microglial Cell Line | Gene: Rplp0 (ribosomal protein lateral stalk subunit P0)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to interleukin-4, cytoplasmic translation, ribosome biogenesis; MF: large ribosomal subunit rRNA binding, peptide binding, structural constituent of ... |
Does Knockout of Tex21 in Embryonic Stem Cell Line causally result in cell proliferation? | 0 | 2,477 | Knockout | Tex21 | cell proliferation | Embryonic Stem Cell Line | Gene: Tex21 (testis expressed gene 21)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q9R0U9, Q497Q3, Q9D4K1, A0A1W2P825
Entrez ID: 80384 |
Does Knockout of Tmem88 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 1,266 | Knockout | Tmem88 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: Tmem88 (transmembrane protein 88)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Wnt signaling pathway, negative regulation of canonical Wnt signaling pathway, protein localization to plasma membrane, protein stabilization; MF: PDZ domain binding, protein binding; ... |
Does Knockout of Tnks1bp1 in Melanoma Cell Line causally result in protein/peptide accumulation? | 0 | 1,839 | Knockout | Tnks1bp1 | protein/peptide accumulation | Melanoma Cell Line | Gene: Tnks1bp1 (tankyrase 1 binding protein 1)
Type: protein-coding
Summary: Predicted to enable ankyrin repeat binding activity and enzyme binding activity. Predicted to be involved in cellular response to ionizing radiation; double-strand break repair; and positive regulation of protein phosphorylatio... |
Does Knockout of C1rb in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity? | 0 | 687 | Knockout | C1rb | tumorigenicity | Immortal Mouse Liver-derived Cell Line | Gene: C1rb (complement component 1, r subcomponent B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: activation of membrane attack complex, complement activation, complement activation, classical pathway, immune system process, innate immune response, killing of cells of... |
Does Knockout of Ptges2 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 0 | 165 | Knockout | Ptges2 | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Ptges2 (prostaglandin E synthase 2)
Type: protein-coding
Summary: The protein encoded by this gene is a Golgi membrane-associated prostaglandin E synthase candidate, which is capable of catalyzing the conversion of prostaglandin H2 to prostaglandin E2 in vitro. However, a study using mice deficien... |
Does Knockout of Zdhhc12 in renal medulla cell line causally result in response to bacteria? | 0 | 2,049 | Knockout | Zdhhc12 | response to bacteria | renal medulla cell line | Gene: Zdhhc12 (zinc finger, DHHC domain containing 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chaperone-mediated autophagy, gamma-aminobutyric acid receptor clustering, gephyrin clustering involved in postsynaptic density assembly, negative regulation of NLRP3 in... |
Does Knockout of Sod2 in renal medulla cell line causally result in response to bacteria? | 0 | 2,049 | Knockout | Sod2 | response to bacteria | renal medulla cell line | Gene: Sod2 (superoxide dismutase 2, mitochondrial)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure, apoptotic mitochondrial changes, cellular response to ethanol, cellular respo... |
Does Knockout of Nemp2 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,279 | Knockout | Nemp2 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: Nemp2 (nuclear envelope integral membrane protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: membrane, nuclear envelope, nuclear inner membrane, nucleus
Pathways:
UniProt: Q8CB65
Entrez ID: 227094 |
Does Knockout of Kat6a in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,271 | Knockout | Kat6a | cell proliferation | Mouse kidney carcinoma cell | Gene: Kat6a (K(lysine) acetyltransferase 6A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: aorta morphogenesis, cellular senescence, chromatin organization, embryonic hemopoiesis, face morphogenesis, heart morphogenesis, myeloid cell differentiation, negative regulation... |
Does Knockout of Map3k13 in Immortal mouse chromaffin cells causally result in cell viability? | 1 | 2,469 | Knockout | Map3k13 | cell viability | Immortal mouse chromaffin cells | Gene: Map3k13 (mitogen-activated protein kinase kinase kinase 13)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: JNK cascade, positive regulation of axon extension, positive regulation of branching morphogenesis of a nerve, positive regulation of neuron maturation, posit... |
Does Knockout of Senp7 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity? | 0 | 2,174 | Knockout | Senp7 | tumorigenicity | Breast Adenocarcinoma Cell Line | Gene: Senp7 (SUMO1/sentrin specific peptidase 7)
Type: protein-coding
Summary: This gene encodes a SUMO deconjugating enzyme of the Sentrin/SUMO-specific protease (SENP) family. The encoded protein is a protease that exhibits deSUMOylating activity towards proteins involved in chromatin remodeling and p... |
Does Knockout of Vwde in Embryonic Stem Cell Line causally result in cell proliferation? | 0 | 579 | Knockout | Vwde | cell proliferation | Embryonic Stem Cell Line | Gene: Vwde (von Willebrand factor D and EGF domains)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, extracellular region
Pathways:
UniProt: Q6DFV8
Entrez ID: 232585 |
Does Knockout of Hnf4a in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 2,308 | Knockout | Hnf4a | response to chemicals | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: Hnf4a (hepatic nuclear factor 4, alpha)
Type: protein-coding
Summary: The protein encoded by this gene is a transcription factor involved in the development of the pancreas, liver, kidney, and intestines. The encoded protein also functions to maintain glucose homeostasis. Several transcript varian... |
Does Knockout of Nlrp4c in pro-B-lymphocyte causally result in response to chemicals? | 0 | 1,720 | Knockout | Nlrp4c | response to chemicals | pro-B-lymphocyte | Gene: Nlrp4c (NLR family, pyrin domain containing 4C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: antiviral innate immune response, biological_process, inflammatory response, negative regulation of innate immune response, proteasome-mediated ubiquitin-dependent protei... |
Does Knockout of Mex3b in renal medulla cell line causally result in response to bacteria? | 0 | 2,049 | Knockout | Mex3b | response to bacteria | renal medulla cell line | Gene: Mex3b (mex3 RNA binding family member B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: establishment of localization in cell, positive regulation of cell-cell adhesion, positive regulation of phagocytosis, protein localization to cell cortex; MF: GTPase activating... |
Does Knockout of Pet117 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity? | 1 | 2,172 | Knockout | Pet117 | tumorigenicity | Breast Adenocarcinoma Cell Line | Gene: Pet117 (PET117 homolog)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: mitochondrion
Pathways:
UniProt: P0DJF2
Entrez ID: 100048644 |
Does Knockout of Herc4 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,685 | Knockout | Herc4 | protein/peptide distribution | myoblast cell line | Gene: Herc4 (hect domain and RLD 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, negative regulation of smoothened signaling pathway, protein ubiquitination, spermatogenesis, ubiquitin-dependent protein catabolic process; MF: transferase activity,... |
Does Knockout of Gatad1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 1 | 81 | Knockout | Gatad1 | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Gatad1 (GATA zinc finger domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, chromatin remodeling, regulation of DNA-templated transcription, regulation of gene expression; MF: metal ion binding, sequence-specific DNA binding... |
Does Knockout of Nme6 in Mouse Embryonic Stem Cell causally result in protein/peptide accumulation? | 0 | 1,077 | Knockout | Nme6 | protein/peptide accumulation | Mouse Embryonic Stem Cell | Gene: Nme6 (NME/NM23 nucleoside diphosphate kinase 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CTP biosynthetic process, GTP biosynthetic process, UTP biosynthetic process, negative regulation of cell growth, negative regulation of mitotic nuclear division, nucleot... |
Does Knockout of Gm7356 in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,278 | Knockout | Gm7356 | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: Gm7356 (predicted gene 7356)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity
Pathways:
UniProt:
Entr... |
Does Knockout of Alg11 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,275 | Knockout | Alg11 | cell proliferation | Colonic Cancer Cell Line | Gene: Alg11 (ALG11 alpha-1,2-mannosyltransferase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: dolichol-linked oligosaccharide biosynthetic process, protein N-linked glycosylation; MF: GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity, glycosyltrans... |
Does Knockout of Shc2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 0 | 83 | Knockout | Shc2 | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Shc2 (SHC (Src homology 2 domain containing) transforming protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell surface receptor protein tyrosine kinase signaling pathway, intracellular signal transduction
Pathways: Alcoholism - Mus musculus (mous... |
Does Knockout of Maf1 in Mouse Embryonic Stem Cell causally result in protein/peptide accumulation? | 0 | 1,077 | Knockout | Maf1 | protein/peptide accumulation | Mouse Embryonic Stem Cell | Gene: Maf1 (MAF1 homolog, negative regulator of RNA polymerase III)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of transcription by RNA polymerase I, negative regulation of transcription by RNA polymerase III; MF: GABA receptor binding, RNA polymer... |
Does Knockout of Llgl2 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,264 | Knockout | Llgl2 | cell proliferation | Colonic Cancer Cell Line | Gene: Llgl2 (LLGL2 scribble cell polarity complex component)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi to plasma membrane transport, L-leucine transport, branching involved in labyrinthine layer morphogenesis, cell division, cortical actin cytoskeleton organiz... |
Does Knockout of Fam118a in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,263 | Knockout | Fam118a | cell proliferation | Colonic Cancer Cell Line | Gene: Fam118a (family with sequence similarity 118, member A)
Type: protein-coding
Summary: Predicted to enable identical protein binding activity. Predicted to be located in membrane. Is expressed in cerebral cortex and cerebral cortex marginal layer. Orthologous to human FAM118A (family with sequence ... |
Does Knockout of Mtif3 in Regulatory T cell causally result in protein/peptide accumulation? | 0 | 1,481 | Knockout | Mtif3 | protein/peptide accumulation | Regulatory T cell | Gene: Mtif3 (mitochondrial translational initiation factor 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial translational initiation, ribosome disassembly, translation, translational initiation; MF: ribosomal small subunit binding, ribosome binding, transl... |
Does Knockout of Etnppl in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 0 | 81 | Knockout | Etnppl | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Etnppl (ethanolamine phosphate phospholyase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, cellular response to glucocorticoid stimulus, ceramide phosphoethanolamine catabolic process, lipid homeostasis, phospholipid transfer to membrane, respo... |
Does Knockout of Prdx2 in Neuroblastoma Cell Line causally result in response to virus? | 0 | 1,422 | Knockout | Prdx2 | response to virus | Neuroblastoma Cell Line | Gene: Prdx2 (peroxiredoxin 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell homeostasis, T cell proliferation, cell redox homeostasis, cellular response to oxidative stress, defense response to tumor cell, hydrogen peroxide catabolic process, hydrogen peroxide me... |
Does Knockout of S100a16 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,271 | Knockout | S100a16 | cell proliferation | Mouse kidney carcinoma cell | Gene: S100a16 (S100 calcium binding protein A16)
Type: protein-coding
Summary: Enables calcium ion binding activity and identical protein binding activity. Acts upstream of or within response to calcium ion. Located in cytoplasm and nucleus. Is expressed in several structures, including brain ventricula... |
Does Knockout of Sag in Embryonic Fibroblast Cell Line causally result in response to virus? | 0 | 1,133 | Knockout | Sag | response to virus | Embryonic Fibroblast Cell Line | Gene: Sag (S-antigen, retina and pineal gland (arrestin))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor internalization, sensory perception, signal transduction; MF: G protein-coupled receptor binding, opsin binding, phosphoprotein binding, sp... |
Does Knockout of Cdc42se2 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 1,273 | Knockout | Cdc42se2 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: Cdc42se2 (CDC42 small effector 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: phagocytosis, regulation of Rho protein signal transduction, regulation of cell shape, regulation of signal transduction; MF: signaling adaptor activity, small GTPase binding; CC: cell... |
Does Knockout of Bysl in breast epithelium causally result in cell cycle progression? | 0 | 1,468 | Knockout | Bysl | cell cycle progression | breast epithelium | Gene: Bysl (bystin-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: blastocyst formation, in utero embryonic development, maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing, ribosome biogenesis, stem cell prolife... |
Does Knockout of Chm in Pancreatic Cancer Cell Line causally result in response to chemicals? | 0 | 2,359 | Knockout | Chm | response to chemicals | Pancreatic Cancer Cell Line | Gene: Chm (CHM Rab escort protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: blood vessel development, intracellular protein transport, protein geranylgeranylation, protein targeting to membrane, small GTPase-mediated signal transduction, vesicle-mediated transport;... |
Does Knockout of Plekha3 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,264 | Knockout | Plekha3 | cell proliferation | Colonic Cancer Cell Line | Gene: Plekha3 (pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: endosome organization, receptor recycling, retrograde transport, endosome to Golgi; MF: identical protein binding, ... |
Does Knockout of Edaradd in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 0 | 1,130 | Knockout | Edaradd | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Edaradd (EDAR associated via death domain)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: canonical NF-kappaB signal transduction, cell differentiation, hair follicle development, odontogenesis of dentin-containing tooth, positive regulation of non-canonical NF-kap... |
Does Knockout of Usf1 in Embryonic Stem Cell Line causally result in cell proliferation? | 0 | 579 | Knockout | Usf1 | cell proliferation | Embryonic Stem Cell Line | Gene: Usf1 (upstream transcription factor 1)
Type: protein-coding
Summary: This protein encoded by this gene is a member of the basic-Helix-Hoop-Helix-Leucine zipper (bHLH-LZ) family and encodes a protein that can act as a transcription factor. Studies indicate that the basic region interacts with DNA a... |
Does Knockout of Usp48 in Embryonic Fibroblast Cell Line causally result in response to virus? | 0 | 1,133 | Knockout | Usp48 | response to virus | Embryonic Fibroblast Cell Line | Gene: Usp48 (ubiquitin specific peptidase 48)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein deubiquitination, proteolysis, regulation of protein stability; MF: cysteine-type deubiquitinase activity, cysteine-type endopeptidase activity, cysteine-type peptidase a... |
Does Knockout of Abi2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 0 | 83 | Knockout | Abi2 | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Abi2 (abl interactor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Rac protein signal transduction, camera-type eye development, cell migration, cell projection morphogenesis, dendrite development, learning or memory, lens fiber cell morphogenesis, mitophagy, n... |
Does Knockout of Kcnh8 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 0 | 161 | Knockout | Kcnh8 | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Kcnh8 (potassium voltage-gated channel, subfamily H (eag-related), member 8)
Type: protein-coding
Summary: Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and delayed rectifier potassium channel activity. Predicted to be involved in negative regul... |
Does Knockout of Pgrmc2 in Melanoma Cell Line causally result in cell proliferation? | 0 | 1,269 | Knockout | Pgrmc2 | cell proliferation | Melanoma Cell Line | Gene: Pgrmc2 (progesterone receptor membrane component 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adipose tissue development, heme transport; MF: heme binding, heme transmembrane transporter activity, lipid binding, protein binding, steroid binding; CC: endomembra... |
Does Knockout of Cyb5d1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 0 | 167 | Knockout | Cyb5d1 | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Cyb5d1 (cytochrome b5 domain containing 1)
Type: protein-coding
Summary: Predicted to enable metal ion binding activity. Predicted to be involved in cilium movement and regulation of cilium beat frequency. Predicted to be located in cell projection; cytoplasm; and cytoskeleton. Is expressed in sev... |
Does Knockout of E2f8 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 0 | 163 | Knockout | E2f8 | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: E2f8 (E2F transcription factor 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell cycle comprising mitosis without cytokinesis, chorionic trophoblast cell differentiation, fibroblast proliferation, hepatocyte differentiation, negative regulation of cytokinesis,... |
Does Knockout of Mettl23 in Immortal mouse chromaffin cells causally result in cell viability? | 0 | 2,469 | Knockout | Mettl23 | cell viability | Immortal mouse chromaffin cells | Gene: Mettl23 (methyltransferase like 23)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, cognition, epigenetic programing of male pronucleus, epigenetic programming in the zygotic pronuclei, epigenetic regulation of gene expression, methylation, p... |
Does Knockout of Aldh1a3 in macrophage causally result in response to bacteria? | 0 | 2,211 | Knockout | Aldh1a3 | response to bacteria | macrophage | Gene: Aldh1a3 (aldehyde dehydrogenase family 1, subfamily A3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Harderian gland development, aldehyde metabolic process, embryonic camera-type eye development, embryonic eye morphogenesis, face development, inner ear morphogen... |
Does Knockout of Tas2r104 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 1,273 | Knockout | Tas2r104 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: Tas2r104 (taste receptor, type 2, member 104)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, detection of chemical stimulus involved in sensory perception of bitter taste, detection of chemical stimulus involved in sens... |
Does Knockout of Pax5 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,264 | Knockout | Pax5 | cell proliferation | Colonic Cancer Cell Line | Gene: Pax5 (paired box 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adult behavior, animal organ morphogenesis, cell differentiation, cerebral cortex development, dopaminergic neuron differentiation, embryonic cranial skeleton morphogenesis, embryonic organ morphoge... |
Does Knockout of Pced1a in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 2,308 | Knockout | Pced1a | response to chemicals | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: Pced1a (PC-esterase domain containing 1A)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q6P1Z5
Entrez ID: 319513 |
Does Knockout of Phf11d in Embryonic Fibroblast Cell Line causally result in cell proliferation? | 0 | 345 | Knockout | Phf11d | cell proliferation | Embryonic Fibroblast Cell Line | Gene: Phf11d (PHD finger protein 11D)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: metal ion binding, molecular_function, zinc ion binding; CC: nuclear membrane, nucleoplasm, nucleus
Pathways:
UniProt: A6H5X4
Entrez ID: 219132 |
Does Knockout of Ccnl1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,268 | Knockout | Ccnl1 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: Ccnl1 (cyclin L1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of RNA splicing, regulation of apoptotic process, regulation of cell cycle, regulation of centrosome cycle, regulation of transcription by RNA polymerase II; MF: cyclin-dependent protein se... |
Does Knockout of Prss12 in Microglial Cell Line causally result in response to virus? | 0 | 2,429 | Knockout | Prss12 | response to virus | Microglial Cell Line | Gene: Prss12 (serine protease 12 neurotrypsin (motopsin))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: exocytosis, proteolysis, zymogen activation; MF: hydrolase activity, peptidase activity, serine-type endopeptidase activity, serine-type peptidase activity; CC: Schaf... |
Does Knockout of Odc1 in Microglial Cell Line causally result in protein/peptide accumulation? | 0 | 1,398 | Knockout | Odc1 | protein/peptide accumulation | Microglial Cell Line | Gene: Odc1 (ornithine decarboxylase, structural 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: alpha-amino acid metabolic process, kidney development, polyamine biosynthetic process, polyamine metabolic process, positive regulation of cell population proliferation, pu... |
Does Knockout of Igfbp7 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity? | 0 | 2,174 | Knockout | Igfbp7 | tumorigenicity | Breast Adenocarcinoma Cell Line | Gene: Igfbp7 (insulin-like growth factor binding protein 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: angiogenesis, cell adhesion, inner ear development, regulation of cell growth, regulation of signal transduction, regulation of steroid biosynthetic process; MF: ex... |
Does Knockout of Ankrd13d in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 0 | 161 | Knockout | Ankrd13d | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Ankrd13d (ankyrin repeat domain 13 family, member D)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of receptor internalization; MF: ubiquitin-modified protein reader activity; CC: cytoplasm, endosome, late endosome, membrane, perinuclear region... |
Does Knockout of Htr2a in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,260 | Knockout | Htr2a | cell proliferation | Mouse kidney carcinoma cell | Gene: Htr2a (5-hydroxytryptamine (serotonin) receptor 2A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger, G protein-coupled serotonin... |
Does Knockout of Sgf29 in myoblast cell line causally result in protein/peptide distribution? | 1 | 1,684 | Knockout | Sgf29 | protein/peptide distribution | myoblast cell line | Gene: Sgf29 (SAGA complex associated factor 29)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, negative regulation of DNA repair, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, regula... |
Does Knockout of Enpp7 in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,277 | Knockout | Enpp7 | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: Enpp7 (ectonucleotide pyrophosphatase/phosphodiesterase 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: fatty acid homeostasis, lipid digestion, lipid metabolic process, negative regulation of DNA replication, negative regulation of cell population proliferation,... |
Does Knockout of Gm5142 in Melanoma Cell Line causally result in cell proliferation? | 0 | 2,492 | Knockout | Gm5142 | cell proliferation | Melanoma Cell Line | Gene: Gm5142 (predicted gene 5142)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q8C5X9
Entrez ID: 380907 |
Does Knockout of Krtap9-1 in Microglial Cell Line causally result in response to virus? | 0 | 1,439 | Knockout | Krtap9-1 | response to virus | Microglial Cell Line | Gene: Krtap9-1 (keratin associated protein 9-1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: identical protein binding, molecular_function; CC: cellular_component, cytosol, intermediate filament, keratin filament
Pathways: Developmental Biology, Keratinization... |
Does Knockout of Syt5 in Microglial Cell Line causally result in protein/peptide distribution? | 0 | 1,585 | Knockout | Syt5 | protein/peptide distribution | Microglial Cell Line | Gene: Syt5 (synaptotagmin V)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: calcium-dependent activation of synaptic vesicle fusion, regulation of calcium ion-dependent exocytosis, regulation of synaptic vesicle exocytosis, vesicle-mediated transport; MF: SNARE binding, ... |
Does Knockout of Hcls1 in Mouse cell causally result in protein/peptide accumulation? | 0 | 1,047 | Knockout | Hcls1 | protein/peptide accumulation | Mouse cell | Gene: Hcls1 (hematopoietic cell specific Lyn substrate 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin filament organization, cell migration, cellular response to cytokine stimulus, erythrocyte differentiation, granulocyte colony-stimulating factor signaling path... |
Does Knockout of Klhl6 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity? | 0 | 688 | Knockout | Klhl6 | tumorigenicity | Immortal Mouse Liver-derived Cell Line | Gene: Klhl6 (kelch-like 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell receptor signaling pathway, germinal center formation, proteasome-mediated ubiquitin-dependent protein catabolic process, response to bacterium; CC: Cul3-RING ubiquitin ligase complex, cytop... |
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