prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Necab2 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,680
|
Knockout
|
Necab2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Necab2 (N-terminal EF-hand calcium binding protein 2)
Type: protein-coding
Summary: Predicted to enable A2A adenosine receptor binding activity; identical protein binding activity; and type 5 metabotropic glutamate receptor binding activity. Predicted to be involved in positive regulation of protein localization to membrane; regulation of amyloid precursor protein biosynthetic process; and regulation of signal transduction. Predicted to be located in plasma membrane. Predicted to be active in cytoplasm. Is expressed in brain; embryo ectoderm; eye; nasal pit; and trigeminal ganglion. Orthologous to human NECAB2 (N-terminal EF-hand calcium binding protein 2). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: negative regulation of G protein-coupled receptor internalization, positive regulation of ERK1 and ERK2 cascade, positive regulation of adenosine receptor signaling pathway, positive regulation of glutamate receptor signaling pathway, positive regulation of protein localization to membrane, regulation of amyloid precursor protein biosynthetic process; MF: A2A adenosine receptor binding, calcium ion binding, identical protein binding, metal ion binding, type 5 metabotropic glutamate receptor binding; CC: axon, cell projection, cytoplasm, dendrite, membrane, plasma membrane, postsynapse, presynapse
Pathways:
UniProt: Q91ZP9
Entrez ID: 117148
|
Does Knockout of Dhcr7 in Immortal mouse chromaffin cells causally result in cell viability?
| 0
| 2,469
|
Knockout
|
Dhcr7
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Dhcr7 (7-dehydrocholesterol reductase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: blood vessel development, cholesterol biosynthetic process, cholesterol biosynthetic process via desmosterol, cholesterol biosynthetic process via lathosterol, cholesterol metabolic process, lipid metabolic process, lung development, lung epithelial cell differentiation, multicellular organism growth, positive regulation of ferroptosis, post-embryonic development, regulation of cell population proliferation, regulation of cholesterol biosynthetic process, steroid biosynthetic process, steroid metabolic process, sterol biosynthetic process; MF: 7-dehydrocholesterol reductase activity, NADP binding, cholesterol-5,6-oxide hydrolase activity, hydrolase activity, oxidoreductase activity, oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, nuclear outer membrane
Pathways: Cholesterol biosynthesis, Cholesterol biosynthesis via desmosterol, Cholesterol biosynthesis via lathosterol, Metabolism, Metabolism of lipids, Metabolism of steroids, Steroid biosynthesis - Mus musculus (mouse), cholesterol biosynthesis I, cholesterol biosynthesis II (via 24,25-dihydrolanosterol), cholesterol biosynthesis III (via desmosterol), superpathway of cholesterol biosynthesis
UniProt: O88455
Entrez ID: 13360
|
Does Knockout of Cyp2u1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 84
|
Knockout
|
Cyp2u1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Cyp2u1 (cytochrome P450, family 2, subfamily u, polypeptide 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: lipid metabolic process, omega-hydroxylase P450 pathway, organic acid metabolic process, steroid metabolic process, xenobiotic metabolic process; MF: arachidonate omega-hydroxylase activity, heme binding, iron ion binding, long-chain fatty acid omega-hydroxylase activity, metal ion binding, monooxygenase activity, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen, steroid hydroxylase activity; CC: cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, intracellular membrane-bounded organelle, membrane, mitochondrial inner membrane, mitochondrion
Pathways: Arachidonate metabolism, Arachidonic acid metabolism - Mus musculus (mouse), Biological oxidations, Cytochrome P450 - arranged by substrate type, Fatty acid degradation - Mus musculus (mouse), Fatty acid metabolism, Metabolism, Metabolism of lipids, Miscellaneous substrates, Phase I - Functionalization of compounds, Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE), bupropion degradation, nicotine degradation II, nicotine degradation III
UniProt: Q9CX98
Entrez ID: 71519
|
Does Knockout of Slc22a15 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 83
|
Knockout
|
Slc22a15
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Slc22a15 (solute carrier family 22 (organic anion/cation transporter), member 15)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: amino acid transport, amino-acid betaine transport, monoatomic ion transport, transmembrane transport; MF: amino-acid betaine transmembrane transporter activity, transmembrane transporter activity; CC: membrane, plasma membrane
Pathways: SLC-mediated transmembrane transport, SLC-mediated transport of organic cations, Transport of small molecules
UniProt: Q504N2
Entrez ID: 242126
|
Does Knockout of Vps26b in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,177
|
Knockout
|
Vps26b
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Vps26b (VPS26 retromer complex component B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to type II interferon, intracellular protein transport, protein transport, regulation of neurotransmitter receptor localization to postsynaptic specialization membrane, retrograde transport, endosome to Golgi; CC: cytoplasm, cytosol, early endosome, endosome, glutamatergic synapse, late endosome, membrane, phagocytic vesicle, postsynaptic early endosome, postsynaptic recycling endosome, retromer complex
Pathways: Endocytosis - Mus musculus (mouse)
UniProt: Q8C0E2
Entrez ID: 69091
|
Does Knockout of Sfmbt2 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,565
|
Knockout
|
Sfmbt2
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Sfmbt2 (Scm-like with four mbt domains 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of DNA-templated transcription, negative regulation of gene expression, regulation of DNA-templated transcription; MF: chromatin binding, histone binding, transcription corepressor activity; CC: aggresome, cytosol, nuclear body, nuclear speck, nucleoplasm, nucleus
Pathways:
UniProt: Q8BG70, Q3UH07, Q3UH63
Entrez ID: 353282
|
Does Knockout of Zfp983 in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Zfp983
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Zfp983 (zinc finger protein 983)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, response to bacterium; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding
Pathways:
UniProt: E9PUT0
Entrez ID: 73229
|
Does Knockout of Dpy19l2 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,308
|
Knockout
|
Dpy19l2
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Dpy19l2 (dpy-19 like 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, spermatid development, spermatogenesis; MF: glycosyltransferase activity, mannosyltransferase activity, protein binding, transferase activity; CC: membrane, nuclear inner membrane, nucleus
Pathways:
UniProt: P0CW70
Entrez ID: 320752
|
Does Knockout of Stip1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,263
|
Knockout
|
Stip1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Stip1 (stress-induced phosphoprotein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: Hsp70 protein binding, Hsp90 protein binding, protein binding, protein-folding chaperone binding; CC: cytoplasm, cytosol, dynein axonemal particle, myelin sheath, nucleus, protein folding chaperone complex, protein-containing complex
Pathways: Cellular responses to stimuli, Cellular responses to stress, HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand, Prion disease - Mus musculus (mouse), RHO GTPase cycle, RND1 GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q60864
Entrez ID: 20867
|
Does Knockout of Pnlip in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,269
|
Knockout
|
Pnlip
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Pnlip (pancreatic lipase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cholesterol homeostasis, fatty acid biosynthetic process, high-density lipoprotein particle remodeling, intestinal cholesterol absorption, lipid catabolic process, lipid metabolic process, post-embryonic development, retinoid metabolic process, retinol metabolic process, triglyceride catabolic process; MF: all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity, carboxylic ester hydrolase activity, hydrolase activity, lipase activity, lipoprotein lipase activity, metal ion binding, phospholipase A1 activity, retinyl-palmitate esterase activity, triacylglycerol lipase activity; CC: extracellular region, extracellular space
Pathways: Digestion, Digestion and absorption, Digestion of dietary lipid, Fat digestion and absorption - Mus musculus (mouse), Glycerolipid metabolism - Mus musculus (mouse), Metabolism, Metabolism of fat-soluble vitamins, Metabolism of vitamins and cofactors, Pancreatic secretion - Mus musculus (mouse), Retinoid metabolism and transport, Sensory Perception, Visual phototransduction, Vitamin digestion and absorption - Mus musculus (mouse)
UniProt: Q6P8U6
Entrez ID: 69060
|
Does Knockout of Lpar1 in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,180
|
Knockout
|
Lpar1
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Lpar1 (lysophosphatidic acid receptor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, Golgi to plasma membrane protein transport, adenylate cyclase-activating G protein-coupled receptor signaling pathway, adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway, bleb assembly, cell chemotaxis, cellular response to 1-oleoyl-sn-glycerol 3-phosphate, cellular response to oxygen levels, cerebellum development, corpus callosum development, myelination, negative regulation of cAMP/PKA signal transduction, negative regulation of cilium assembly, negative regulation of neuron projection development, neurogenesis, oligodendrocyte development, optic nerve development, phospholipase C-activating G protein-coupled receptor signaling pathway, positive regulation of MAPK cascade, positive regulation of Rho protein signal transduction, positive regulation of apoptotic process, positive regulation of canonical NF-kappaB signal transduction, positive regulation of cilium assembly, positive regulation of dendritic spine development, positive regulation of smooth muscle cell chemotaxis, positive regulation of stress fiber assembly, protein localization to cilium, regulation of cell shape, regulation of postsynaptic neurotransmitter receptor internalization, regulation of synaptic vesicle cycle, regulation of vesicle-mediated transport, signal transduction; MF: G protein-coupled receptor activity, G-protein alpha-subunit binding, PDZ domain binding, lysophosphatidic acid binding, lysophosphatidic acid receptor activity, phospholipid binding, protein binding; CC: GABA-ergic synapse, cell surface, cytoplasm, dendritic shaft, dendritic spine, endocytic vesicle, endosome, glutamatergic synapse, membrane, neuronal cell body, plasma membrane, postsynaptic membrane, presynaptic membrane
Pathways: Class A/1 (Rhodopsin-like receptors), G alpha (i) signalling events, G alpha (q) signalling events, GPCR downstream signalling, GPCR ligand binding, Gap junction - Mus musculus (mouse), Lysosphingolipid and LPA receptors, Neuroactive ligand-receptor interaction - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Phospholipase D signaling pathway - Mus musculus (mouse), Rap1 signaling pathway - Mus musculus (mouse), Regulation of actin cytoskeleton - Mus musculus (mouse), Signal Transduction, Signaling by GPCR
UniProt: P61793
Entrez ID: 14745
|
Does Knockout of Dchs2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,285
|
Knockout
|
Dchs2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Dchs2 (dachsous cadherin related 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: branching involved in ureteric bud morphogenesis, cell adhesion, cell differentiation, cell-cell adhesion, condensed mesenchymal cell proliferation, digestive tract development, establishment or maintenance of cell polarity, heart morphogenesis, hippo signaling, homophilic cell adhesion via plasma membrane adhesion molecules, nephron development, ossification involved in bone maturation; MF: calcium ion binding; CC: cell-cell junction, membrane, plasma membrane
Pathways: Hippo signaling pathway - multiple species - Mus musculus (mouse)
UniProt: A0A0A6YW72
Entrez ID: 100534287
|
Does Knockout of 4930555G01Rik in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,838
|
Knockout
|
4930555G01Rik
|
cell proliferation
|
Melanoma Cell Line
|
Gene: 4930555G01Rik (RIKEN cDNA 4930555G01 gene)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID:
|
Does Knockout of Leng8 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Leng8
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Leng8 (leukocyte receptor cluster (LRC) member 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q8CBY3
Entrez ID: 232798
|
Does Knockout of Srek1ip1 in macrophage causally result in phagocytosis?
| 0
| 1,889
|
Knockout
|
Srek1ip1
|
phagocytosis
|
macrophage
|
Gene: Srek1ip1 (splicing regulatory glutamine/lysine-rich protein 1interacting protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, biological_process, mRNA processing; MF: metal ion binding, molecular_function, nucleic acid binding, zinc ion binding
Pathways:
UniProt: Q4V9W2
Entrez ID: 67288
|
Does Knockout of Crnkl1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,272
|
Knockout
|
Crnkl1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Crnkl1 (crooked neck pre-mRNA splicing factor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA processing, RNA splicing, mRNA processing, mRNA splicing, via spliceosome, spliceosomal complex assembly; MF: RNA binding; CC: Prp19 complex, U2-type catalytic step 2 spliceosome, catalytic step 2 spliceosome, nuclear speck, nucleus, post-mRNA release spliceosomal complex, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: P63154
Entrez ID: 66877
|
Does Knockout of Ndufs1 in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Ndufs1
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Ndufs1 (NADH:ubiquinone oxidoreductase core subunit S1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ATP synthesis coupled electron transport, aerobic respiration, cellular respiration, mitochondrial electron transport, NADH to ubiquinone, mitochondrial respiratory chain complex I assembly, proton motive force-driven mitochondrial ATP synthesis, proton transmembrane transport; MF: 2 iron, 2 sulfur cluster binding, 4 iron, 4 sulfur cluster binding, NADH dehydrogenase (ubiquinone) activity, electron transfer activity, iron-sulfur cluster binding, metal ion binding, oxidoreductase activity, oxidoreductase activity, acting on NAD(P)H, protein binding; CC: membrane, mitochondrial inner membrane, mitochondrial intermembrane space, mitochondrion, myelin sheath, respiratory chain complex I
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Complex I biogenesis, Diabetic cardiomyopathy - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Metabolism, Metabolism of proteins, Mitochondrial protein degradation, NADH to cytochrome <i>bd</i> oxidase electron transfer I, NADH to cytochrome <i>bo</i> oxidase electron transfer I, Non-alcoholic fatty liver disease - Mus musculus (mouse), Oxidative phosphorylation - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Respiratory electron transport, Retrograde endocannabinoid signaling - Mus musculus (mouse), Thermogenesis - Mus musculus (mouse), aerobic respiration -- electron donor II
UniProt: Q91VD9
Entrez ID: 227197
|
Does Knockout of Ppp4r3a in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,399
|
Knockout
|
Ppp4r3a
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Ppp4r3a (protein phosphatase 4 regulatory subunit 3A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, gluconeogenesis, positive regulation of gluconeogenesis, regulation of double-strand break repair; MF: protein binding, protein phosphatase activator activity, protein phosphatase regulator activity; CC: centrosome, cytoplasm, cytoskeleton, cytosol, nuclear speck, nucleoplasm, nucleus, protein phosphatase 4 complex
Pathways: Glucagon signaling pathway - Mus musculus (mouse)
UniProt: Q6P2K6
Entrez ID: 68734
|
Does Knockout of Vmn2r38 in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,399
|
Knockout
|
Vmn2r38
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Vmn2r38 (vomeronasal 2, receptor 38)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, signal transduction; MF: G protein-coupled receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: G3UYA8
Entrez ID: 434110
|
Does Knockout of Chil6 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,261
|
Knockout
|
Chil6
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Chil6 (chitinase-like 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: carbohydrate metabolic process, chitin catabolic process, positive regulation of chemokine production, production of molecular mediator involved in inflammatory response; MF: chitin binding, chitinase activity, kinase binding; CC: extracellular region, extracellular space
Pathways: Amino sugar and nucleotide sugar metabolism - Mus musculus (mouse)
UniProt: Q80W26
Entrez ID: 229688
|
Does Knockout of Xpo4 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,269
|
Knockout
|
Xpo4
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Xpo4 (exportin 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: glycolytic process, nuclear transport, positive regulation of protein export from nucleus, protein export from nucleus, protein transport; MF: nuclear export signal receptor activity, small GTPase binding; CC: cytoplasm, cytosol, nuclear pore, nucleoplasm, nucleus
Pathways: Nucleocytoplasmic transport - Mus musculus (mouse)
UniProt: Q9ESJ0
Entrez ID: 57258
|
Does Knockout of Trim17 in Regulatory T cell causally result in cell proliferation?
| 0
| 2,127
|
Knockout
|
Trim17
|
cell proliferation
|
Regulatory T cell
|
Gene: Trim17 (tripartite motif-containing 17)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagy, innate immune response, protein autoubiquitination, protein ubiquitination, regulation of gene expression, regulation of protein localization; MF: metal ion binding, protein-macromolecule adaptor activity, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: cytoplasm, lysosome
Pathways:
UniProt: Q7TPM3
Entrez ID: 56631
|
Does Knockout of Tmprss9 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Tmprss9
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Tmprss9 (transmembrane protease, serine 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: plasminogen activation, proteolysis; MF: hydrolase activity, peptidase activity, serine-type endopeptidase activity, serine-type peptidase activity; CC: membrane, plasma membrane
Pathways:
UniProt: D3YTR8
Entrez ID: 432478
|
Does Knockout of Rpusd4 in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Rpusd4
|
cell cycle progression
|
breast epithelium
|
Gene: Rpusd4 (RNA pseudouridylate synthase domain containing 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA modification, RNA splicing, mRNA processing, mRNA pseudouridine synthesis, mitochondrial tRNA pseudouridine synthesis, positive regulation of mitochondrial translation, pseudouridine synthesis, rRNA processing, rRNA pseudouridine synthesis, tRNA processing; MF: RNA binding, isomerase activity, mitochondrial ribosomal large subunit rRNA binding, pseudouridine synthase activity, tRNA binding, tRNA pseudouridine synthase activity; CC: cytoplasm, mitochondrial matrix, mitochondrion, nucleoplasm, nucleus, ribonucleoprotein granule
Pathways:
UniProt: Q9CWX4
Entrez ID: 71989
|
Does Knockout of Pole2 in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Pole2
|
cell cycle progression
|
breast epithelium
|
Gene: Pole2 (polymerase (DNA directed), epsilon 2 (p59 subunit))
Type: protein-coding
Summary: Predicted to enable DNA binding activity. Predicted to be involved in DNA-templated DNA replication and error-prone translesion synthesis. Predicted to be located in nuclear body. Predicted to be part of epsilon DNA polymerase complex. Is expressed in several structures, including brain; limb mesenchyme; musculature; respiratory system; and tongue. Orthologous to human POLE2 (DNA polymerase epsilon 2, accessory subunit). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: DNA metabolic process, DNA replication, DNA-templated DNA replication, error-prone translesion synthesis; CC: chromosome, epsilon DNA polymerase complex, nuclear body, nuclear lumen, nucleoplasm, nucleus
Pathways: Activation of the pre-replicative complex, Base Excision Repair, Base excision repair - Mus musculus (mouse), Cell Cycle, Cell Cycle, Mitotic, DNA Damage Bypass, DNA Double-Strand Break Repair, DNA Repair, DNA Replication, DNA Replication Pre-Initiation, DNA replication - Mus musculus (mouse), DNA replication initiation, Dual Incision in GG-NER, Dual incision in TC-NER, G1/S Transition, Gap-filling DNA repair synthesis and ligation in GG-NER, Gap-filling DNA repair synthesis and ligation in TC-NER, Global Genome Nucleotide Excision Repair (GG-NER), HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homology Directed Repair, Mitotic G1 phase and G1/S transition, Nucleotide Excision Repair, Nucleotide excision repair - Mus musculus (mouse), PCNA-Dependent Long Patch Base Excision Repair, Recognition of DNA damage by PCNA-containing replication complex, Resolution of AP sites via the multiple-nucleotide patch replacement pathway, Resolution of Abasic Sites (AP sites), S Phase, Synthesis of DNA, Termination of translesion DNA synthesis, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
UniProt: O54956
Entrez ID: 18974
|
Does Knockout of Synpo2l in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,683
|
Knockout
|
Synpo2l
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Synpo2l (synaptopodin 2-like)
Type: protein-coding
Summary: Predicted to enable actin binding activity. Involved in several processes, including positive regulation of Rho protein signal transduction; positive regulation of stress fiber assembly; and sarcomere organization. Located in Z disc and nucleus. Is expressed in several structures, including blood vessel; embryo mesenchyme; extrinsic ocular pre-muscle mass; heart; and musculature. Orthologous to human SYNPO2L (synaptopodin 2 like). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: heart morphogenesis, positive regulation of Rho protein signal transduction, positive regulation of actin filament bundle assembly, positive regulation of stress fiber assembly, sarcomere organization; MF: actin binding, protein binding; CC: Z disc, actin cytoskeleton, cytoplasm, cytoskeleton, nucleus, organelle
Pathways:
UniProt: Q8BWB1
Entrez ID: 68760
|
Does Knockout of Lamtor2 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Lamtor2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Lamtor2 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: TORC1 signaling, cellular response to amino acid stimulus, fibroblast migration, intracellular protein localization, positive regulation of MAPK cascade, positive regulation of TOR signaling, positive regulation of TORC1 signaling, positive regulation of intracellular signal transduction, protein localization to cell junction, regulation of cell growth, regulation of cell-substrate junction organization; MF: guanyl-nucleotide exchange factor activity, molecular adaptor activity, protein binding; CC: FNIP-folliculin RagC/D GAP, Ragulator complex, cytoplasm, endosome, late endosome, late endosome membrane, lysosomal membrane, lysosome, membrane
Pathways: Amino acids regulate mTORC1, Autophagy, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Energy dependent regulation of mTOR by LKB1-AMPK, Gene expression (Transcription), Generic Transcription Pathway, Immune System, Innate Immune System, Intracellular signaling by second messengers, MAP2K and MAPK activation, MAPK family signaling cascades, MAPK1/MAPK3 signaling, MTOR signalling, Macroautophagy, Neutrophil degranulation, PIP3 activates AKT signaling, PTEN Regulation, RAF/MAP kinase cascade, RNA Polymerase II Transcription, Regulation of PTEN gene transcription, Signal Transduction, TP53 Regulates Metabolic Genes, Transcriptional Regulation by TP53, mTOR signaling pathway - Mus musculus (mouse), mTORC1-mediated signalling
UniProt: Q9JHS3
Entrez ID: 83409
|
Does Knockout of Cbx8 in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,177
|
Knockout
|
Cbx8
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Cbx8 (chromobox 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to hydrogen peroxide, chromatin organization, heterochromatin formation, negative regulation of transcription by RNA polymerase II, positive regulation of DNA repair, positive regulation of cell population proliferation, positive regulation of collagen biosynthetic process; MF: chromatin binding, histone H3K27me3 reader activity, protein binding, single-stranded RNA binding, ubiquitin-protein transferase activator activity; CC: PRC1 complex, PcG protein complex, chromatin, chromosome, heterochromatin, nucleoplasm, nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Metabolism of proteins, Post-translational protein modification, RNA Polymerase II Transcription, RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, SUMOylation of RNA binding proteins, SUMOylation of chromatin organization proteins, SUMOylation of transcription cofactors, Transcriptional regulation by RUNX1
UniProt: Q9QXV1
Entrez ID: 30951
|
Does Knockout of Inppl1 in Melanoma Cell Line causally result in tumorigenicity?
| 0
| 2,187
|
Knockout
|
Inppl1
|
tumorigenicity
|
Melanoma Cell Line
|
Gene: Inppl1 (inositol polyphosphate phosphatase-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ERK1 and ERK2 cascade, actin filament organization, apoptotic process, cell adhesion, endochondral ossification, endocytosis, establishment of mitotic spindle orientation, gene expression, glucose metabolic process, immune system process, inositol trisphosphate metabolic process, lipid metabolic process, negative regulation of DNA replication, negative regulation of cell population proliferation, negative regulation of gene expression, negative regulation of insulin receptor signaling pathway, negative regulation of insulin-like growth factor receptor signaling pathway, negative regulation of neuron projection development, negative regulation of platelet-derived growth factor receptor signaling pathway, phosphatidylinositol 3-kinase/protein kinase B signal transduction, phosphatidylinositol biosynthetic process, phosphatidylinositol dephosphorylation, post-embryonic development, regulation of actin filament organization, regulation of immune response, regulation of protein localization, response to insulin, ruffle assembly; MF: SH2 domain binding, SH3 domain binding, actin binding, hydrolase activity, inositol-polyphosphate 5-phosphatase activity, phosphatase activity, phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity, phosphatidylinositol-3,4,5-trisphosphate binding, protein binding; CC: Golgi apparatus, basal plasma membrane, cell projection, cytoplasm, cytoskeleton, cytosol, filopodium, lamellipodium, membrane, nuclear speck, nucleus, plasma membrane, spindle pole
Pathways: B cell receptor signaling pathway - Mus musculus (mouse), Cytokine Signaling in Immune system, Fc gamma R-mediated phagocytosis - Mus musculus (mouse), Immune System, Inositol phosphate metabolism, Inositol phosphate metabolism - Mus musculus (mouse), Insulin signaling pathway - Mus musculus (mouse), Interleukin receptor SHC signaling, Interleukin-2 family signaling, Interleukin-3, Interleukin-5 and GM-CSF signaling, Metabolism, Metabolism of lipids, PI Metabolism, Phosphatidylinositol signaling system - Mus musculus (mouse), Phospholipid metabolism, Signaling by Interleukins, Synthesis of IP3 and IP4 in the cytosol, Synthesis of PIPs at the plasma membrane
UniProt: Q6P549
Entrez ID: 16332
|
Does Knockout of Adam10 in Neuroblastoma Cell Line causally result in response to virus?
| 0
| 1,422
|
Knockout
|
Adam10
|
response to virus
|
Neuroblastoma Cell Line
|
Gene: Adam10 (a disintegrin and metallopeptidase domain 10)
Type: protein-coding
Summary: This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. The encoded preproprotein undergoes proteolytic processing to generate a mature enzyme that is involved in the proteolytic release of membrane-bound proteins in a process called ectodomain shedding. Mice lacking the encoded protein die in utero with multiple defects of the developing central nervous system, somites, and cardiovascular system. [provided by RefSeq, May 2016].
Gene Ontology: BP: ERBB2-ERBB4 signaling pathway, Notch receptor processing, Notch signaling pathway, adherens junction organization, amyloid precursor protein catabolic process, amyloid-beta formation, cochlea development, constitutive protein ectodomain proteolysis, epidermal growth factor receptor ligand maturation, epidermal growth factor receptor signaling pathway, in utero embryonic development, membrane protein ectodomain proteolysis, monocyte activation, negative regulation of cell adhesion, negative regulation of gene expression, pore complex assembly, positive regulation of T cell chemotaxis, positive regulation of apoptotic process, positive regulation of cell growth, positive regulation of cell migration, positive regulation of cell population proliferation, positive regulation of neuron projection development, positive regulation of tumor necrosis factor production, positive regulation of tumor necrosis factor-mediated signaling pathway, postsynapse organization, protein catabolic process at postsynapse, protein processing, proteolysis, regulation of Notch signaling pathway, regulation of dendritic spine morphogenesis, regulation of neurotransmitter receptor localization to postsynaptic specialization membrane, regulation of postsynapse organization, regulation of vasculature development, response to tumor necrosis factor, signaling receptor ligand precursor processing; MF: SH3 domain binding, endopeptidase activity, hydrolase activity, metal ion binding, metallodipeptidase activity, metalloendopeptidase activity, metalloendopeptidase activity involved in amyloid precursor protein catabolic process, metallopeptidase activity, peptidase activity, protein binding, protein homodimerization activity; CC: Golgi apparatus, Golgi membrane, Golgi-associated vesicle, adherens junction, anchoring junction, axon, cell projection, cell surface, clathrin-coated vesicle, cytoplasm, cytoplasmic vesicle, dendrite, dendritic spine, extracellular matrix, glutamatergic synapse, membrane, neuronal cell body, perinuclear endoplasmic reticulum, plasma membrane, pore complex, postsynapse, postsynaptic density, postsynaptic membrane, synaptic membrane, synaptic vesicle, tetraspanin-enriched microdomain, trans-Golgi network
Pathways: Alzheimer disease - Mus musculus (mouse), Degradation of the extracellular matrix, Extracellular matrix organization, Immune System, Innate Immune System, Metabolism of proteins, NOTCH3 Activation and Transmission of Signal to the Nucleus, Neutrophil degranulation, Post-translational protein modification, Post-translational protein phosphorylation, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Signal Transduction, Signaling by NOTCH, Signaling by NOTCH3
UniProt: O35598
Entrez ID: 11487
|
Does Knockout of Ttk in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Ttk
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Ttk (Ttk protein kinase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromosome segregation, female meiosis chromosome segregation, meiotic spindle assembly checkpoint signaling, mitotic spindle assembly checkpoint signaling, nuclear chromosome segregation, nuclear division, protein localization to chromosome, protein localization to kinetochore, protein localization to meiotic spindle midzone, repair of mitotic kinetochore microtubule attachment defect; MF: ATP binding, identical protein binding, kinase activity, nucleotide binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, protein serine/threonine/tyrosine kinase activity, protein tyrosine kinase activity, transferase activity; CC: cytoplasm, kinetochore, membrane, nucleus
Pathways: Cell cycle - Mus musculus (mouse)
UniProt: P35761
Entrez ID: 22137
|
Does Knockout of Tspan7 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,272
|
Knockout
|
Tspan7
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Tspan7 (tetraspanin 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: membrane, plasma membrane, postsynapse
Pathways: Glutamate binding, activation of AMPA receptors and synaptic plasticity, Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, Trafficking of AMPA receptors, Trafficking of GluR2-containing AMPA receptors, Transcriptional misregulation in cancer - Mus musculus (mouse), Transmission across Chemical Synapses
UniProt: Q62283
Entrez ID: 21912
|
Does Knockout of Dcdc2a in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,683
|
Knockout
|
Dcdc2a
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Dcdc2a (doublecortin domain containing 2a)
Type: protein-coding
Summary: This gene encodes a member of the doublecortin family. The protein encoded by this gene contains two doublecortin domains. The doublecortin domain has been demonstrated to bind tubulin and enhance microtubule polymerization. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Sep 2010].
Gene Ontology: BP: cell projection organization, cilium assembly, dendrite morphogenesis, intracellular signal transduction, nervous system development, neuron migration, neuronal action potential, regulation of Wnt signaling pathway, regulation of cilium assembly, sensory perception of sound, synaptic transmission, glutamatergic, visual learning; MF: kinesin binding, molecular_function; CC: axoneme, cell projection, cilium, cytoplasm, cytoskeleton, kinocilium, microtubule, microtubule organizing center, synapse
Pathways:
UniProt: Q5DU00
Entrez ID: 195208
|
Does Knockout of Fignl1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Fignl1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Fignl1 (fidgetin-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ATP metabolic process, cellular response to ionizing radiation, male meiotic nuclear division, microtubule severing, negative regulation of apoptotic process, negative regulation of intrinsic apoptotic signaling pathway, osteoblast differentiation, osteoblast proliferation, regulation of cell cycle, regulation of double-strand break repair via homologous recombination; MF: ATP binding, ATP hydrolysis activity, hydrolase activity, magnesium ion binding, metal ion binding, microtubule severing ATPase activity, nucleotide binding; CC: cytoplasm, nuclear chromosome, nucleus, perinuclear region of cytoplasm
Pathways: Cell Cycle, DNA Double-Strand Break Repair, DNA Repair, HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homology Directed Repair, Meiosis, Meiotic recombination, Reproduction, Resolution of D-Loop Structures, Resolution of D-loop Structures through Holliday Junction Intermediates
UniProt: Q8BPY9
Entrez ID: 60530
|
Does Knockout of Nes in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,259
|
Knockout
|
Nes
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Nes (nestin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G2/M transition of mitotic cell cycle, brain development, cell projection morphogenesis, embryonic camera-type eye development, negative regulation of neuron apoptotic process, nervous system development, positive regulation of intermediate filament depolymerization, positive regulation of neural precursor cell proliferation, stem cell proliferation; MF: CCR5 chemokine receptor binding, intermediate filament binding, protein binding; CC: cytoplasm, intermediate filament, intermediate filament cytoskeleton
Pathways:
UniProt: Q6P5H2
Entrez ID: 18008
|
Does Knockout of Calu in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Calu
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Calu (calumenin)
Type: protein-coding
Summary: Enables calcium ion binding activity. Located in endoplasmic reticulum. Is expressed in several structures, including central nervous system; genitourinary system; gut; heart; and immune system. Orthologous to human CALU (calumenin). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: MF: calcium ion binding, enzyme binding, enzyme inhibitor activity, metal ion binding; CC: Golgi apparatus, endoplasmic reticulum, endoplasmic reticulum lumen, endoplasmic reticulum membrane, extracellular region, melanosome, membrane, sarcoplasmic reticulum, sarcoplasmic reticulum lumen
Pathways: Metabolism of proteins, Post-translational protein modification, Post-translational protein phosphorylation, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
UniProt: O35887
Entrez ID: 12321
|
Does Knockout of Ndp in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,681
|
Knockout
|
Ndp
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Ndp (Norrie disease (pseudoglioma) (human))
Type: protein-coding
Summary: This gene encodes a secreted protein that acts a ligand for multiple different receptors and participates in both Wnt and Wnt-independant signalling. Its activity is important in vascular development of the eye and inner ear. Mutation of the related gene in humans causes Norrie syndrome. [provided by RefSeq, May 2015].
Gene Ontology: BP: L-serine metabolic process, Norrin signaling pathway, Wnt signaling pathway, action potential, angiogenesis, blood vessel remodeling, canonical Wnt signaling pathway, cell population proliferation, cellular response to hypoxia, cone retinal bipolar cell differentiation, decidualization, dendrite development, dendritic spine development, endothelial cell differentiation, establishment of blood-brain barrier, establishment of blood-retinal barrier, exploration behavior, extracellular matrix-cell signaling, gene expression, glutathione metabolic process, glycine metabolic process, inflammatory response, intracellular protein localization, lens development in camera-type eye, microglia differentiation, microglial cell proliferation, mitotic cell cycle, nervous system development, neural retina development, neuron apoptotic process, neuron differentiation, optic nerve development, placenta development, positive regulation of DNA-templated transcription, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of transcription by RNA polymerase II, protein targeting to lysosome, protein ubiquitination, re-entry into mitotic cell cycle, regulation of signal transduction, response to axon injury, response to hypoxia, retina blood vessel maintenance, retina development in camera-type eye, retina layer formation, retina morphogenesis in camera-type eye, retina vasculature development in camera-type eye, retina vasculature morphogenesis in camera-type eye, retinal blood vessel morphogenesis, retinal ganglion cell axon guidance, retinal pigment epithelium development, retinal rod cell differentiation, smoothened signaling pathway, transcription by RNA polymerase II, transforming growth factor beta receptor signaling pathway, tricarboxylic acid cycle, ubiquitin-dependent endocytosis; MF: cytokine activity, frizzled binding, protein homodimerization activity; CC: cell surface, extracellular matrix, extracellular region, extracellular space
Pathways:
UniProt: P48744
Entrez ID: 17986
|
Does Knockout of 1700029F12Rik in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,399
|
Knockout
|
1700029F12Rik
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: 1700029F12Rik (RIKEN cDNA 1700029F12 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q810S0, Q9CRB4
Entrez ID: 66479
|
Does Knockout of Cdkl4 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Cdkl4
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Cdkl4 (cyclin dependent kinase like 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: ATP binding, cyclin-dependent protein serine/threonine kinase activity, kinase activity, nucleotide binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cytoplasm, nucleus
Pathways:
UniProt: Q3TZA2
Entrez ID: 381113
|
Does Knockout of Msr1 in pro-B-lymphocyte causally result in response to chemicals?
| 0
| 1,720
|
Knockout
|
Msr1
|
response to chemicals
|
pro-B-lymphocyte
|
Gene: Msr1 (macrophage scavenger receptor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: amyloid-beta clearance, cholesterol transport, endocytosis, establishment of localization in cell, lipoprotein transport, negative regulation of gene expression, phagocytosis, engulfment, plasma lipoprotein particle clearance, positive regulation of cholesterol storage, positive regulation of macrophage derived foam cell differentiation, receptor-mediated endocytosis; MF: amyloid-beta binding, cargo receptor activity, low-density lipoprotein particle binding, scavenger receptor activity; CC: collagen trimer, low-density lipoprotein particle, membrane, plasma membrane
Pathways: Binding and Uptake of Ligands by Scavenger Receptors, Phagosome - Mus musculus (mouse), Scavenging by Class A Receptors, Vesicle-mediated transport
UniProt: P30204
Entrez ID: 20288
|
Does Knockout of Fam174b in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Fam174b
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Fam174b (family with sequence similarity 174, member B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi organization; CC: Golgi apparatus, membrane, plasma membrane
Pathways:
UniProt: Q8K064
Entrez ID: 100038347
|
Does Knockout of A630095N17Rik in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,838
|
Knockout
|
A630095N17Rik
|
cell proliferation
|
Melanoma Cell Line
|
Gene: A630095N17Rik (RIKEN cDNA A630095N17 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: J3QMK5, J3KMM7, A0A087WQ76
Entrez ID: 381272
|
Does Knockout of Il5ra in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Il5ra
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Il5ra (interleukin 5 receptor, alpha)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytokine-mediated signaling pathway, eosinophil differentiation, inflammatory response to antigenic stimulus, interleukin-5-mediated signaling pathway, positive regulation of cell population proliferation, regulation of interleukin-5 production; MF: cytokine binding, cytokine receptor activity, interleukin-5 receptor activity; CC: external side of plasma membrane, membrane, plasma membrane, receptor complex
Pathways: Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Mus musculus (mouse), Hematopoietic cell lineage - Mus musculus (mouse), Immune System, Interleukin receptor SHC signaling, Interleukin-2 family signaling, Interleukin-3, Interleukin-5 and GM-CSF signaling, JAK-STAT signaling pathway - Mus musculus (mouse), MAPK family signaling cascades, MAPK1/MAPK3 signaling, Pathways in cancer - Mus musculus (mouse), RAF/MAP kinase cascade, Signal Transduction, Signaling by Interleukins
UniProt: P21183
Entrez ID: 16192
|
Does Knockout of Rsbn1l in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,399
|
Knockout
|
Rsbn1l
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Rsbn1l (round spermatid basic protein 1-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: dioxygenase activity, metal ion binding, molecular_function, oxidoreductase activity; CC: nucleus
Pathways:
UniProt: A0A0G2JDQ6, D3Z0K6, A0A0G2JEI9
Entrez ID: 242860
|
Does Knockout of Txndc8 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 2,173
|
Knockout
|
Txndc8
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Txndc8 (thioredoxin domain containing 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, spermatogenesis; CC: Golgi apparatus, acrosomal vesicle, cytoplasm, sperm flagellum
Pathways:
UniProt: Q69AB2
Entrez ID: 67402
|
Does Knockout of Acer1 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,266
|
Knockout
|
Acer1
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Acer1 (alkaline ceramidase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, cellular response to calcium ion, ceramide catabolic process, ceramide metabolic process, epidermis development, keratinocyte differentiation, lipid metabolic process, regulation of lipid metabolic process, response to alkaline pH, sebaceous gland development, sphingolipid biosynthetic process, sphingolipid metabolic process, sphingosine biosynthetic process; MF: N-acylsphingosine amidohydrolase activity, hydrolase activity, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides, metal ion binding; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Metabolism, Metabolism of lipids, Sphingolipid catabolism, Sphingolipid metabolism, Sphingolipid metabolism - Mus musculus (mouse), Sphingolipid signaling pathway - Mus musculus (mouse), sphingosine and sphingosine-1-phosphate metabolism
UniProt: Q8R4X1
Entrez ID: 171168
|
Does Knockout of Trp53tg5 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 82
|
Knockout
|
Trp53tg5
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Trp53tg5 (transformation related protein 53 target 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: chromosome, nucleolus
Pathways:
UniProt: Q9D976
Entrez ID: 73603
|
Does Knockout of Slamf9 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
Slamf9
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Slamf9 (SLAM family member 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell activation, defense response to bacterium, immune response, plasmacytoid dendritic cell chemotaxis, plasmacytoid dendritic cell differentiation; CC: cell surface, external side of plasma membrane, membrane
Pathways:
UniProt: Q9D780
Entrez ID: 98365
|
Does Knockout of Fastk in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 1,664
|
Knockout
|
Fastk
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Fastk (Fas-activated serine/threonine kinase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, mitochondrial RNA processing, regulation of RNA splicing, regulation of mitochondrial mRNA stability; MF: ATP binding, Fas-activated serine/threonine kinase activity, RNA binding, kinase activity, nucleotide binding, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: mitochondrial matrix, mitochondrion, nuclear speck, ribonucleoprotein granule
Pathways:
UniProt: Q91WQ6, Q8C725, D6RCW0, E9QA06, D3Z4M5
Entrez ID: 66587
|
Does Knockout of Msl1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,683
|
Knockout
|
Msl1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Msl1 (male specific lethal 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, chromatin remodeling, positive regulation of DNA-templated transcription; MF: protein binding, protein-macromolecule adaptor activity; CC: MSL complex, nuclear speck, nucleoplasm, nucleus
Pathways: Chromatin modifying enzymes, Chromatin organization, HATs acetylate histones
UniProt: Q6PDM1
Entrez ID: 74026
|
Does Knockout of Slc7a11 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,271
|
Knockout
|
Slc7a11
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Slc7a11 (solute carrier family 7 (cationic amino acid transporter, y+ system), member 11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: L-cystine transport, L-glutamate import across plasma membrane, L-glutamate transmembrane transport, L-kynurenine transmembrane transport, adult behavior, amino acid transmembrane transport, amino acid transport, brain development, cellular response to oxidative stress, cellular response to stress, dipeptide import across plasma membrane, glutathione metabolic process, glutathione transmembrane transport, intracellular glutamate homeostasis, limb development, lung alveolus development, lysosomal lumen pH elevation, modulation of chemical synaptic transmission, negative regulation of ferroptosis, platelet aggregation, proton transmembrane transport, regulation of AMPA glutamate receptor clustering, regulation of cell population proliferation, regulation of cellular response to oxidative stress, regulation of cysteine metabolic process, regulation of glutamate metabolic process, regulation of glutathione biosynthetic process, regulation of melanin biosynthetic process, regulation of neutrophil apoptotic process, regulation of programmed cell death, regulation of protein transport, regulation of synapse organization, response to redox state, response to toxic substance, striatum development, transmembrane transport, ventricular system development, visual learning; MF: L-amino acid transmembrane transporter activity, L-kynurenine transmembrane transporter activity, cystine:glutamate antiporter activity, leak channel activity, proton channel activity, transmembrane transporter activity; CC: apical part of cell, astrocyte projection, brush border membrane, cell projection, cell surface, lysosomal membrane, membrane, microvillus membrane, plasma membrane
Pathways: Amino acid transport across the plasma membrane, Basigin interactions, Cell surface interactions at the vascular wall, Ferroptosis - Mus musculus (mouse), Hemostasis, SLC-mediated transmembrane transport, SLC-mediated transport of amino acids, Transport of small molecules
UniProt: Q9WTR6
Entrez ID: 26570
|
Does Knockout of Ap2s1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Ap2s1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Ap2s1 (adaptor-related protein complex 2, sigma 1 subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: clathrin-dependent endocytosis, endocytosis, intracellular protein transport, postsynaptic neurotransmitter receptor internalization, protein transport, synaptic vesicle endocytosis, vesicle-mediated transport; MF: clathrin adaptor activity, protein binding; CC: AP-2 adaptor complex, clathrin-coated pit, cytoplasmic side of plasma membrane, extrinsic component of presynaptic endocytic zone membrane, glutamatergic synapse, intracellular membrane-bounded organelle, membrane, membrane coat, plasma membrane, postsynapse, presynapse, synapse, synaptic vesicle
Pathways: Adaptive Immune System, Axon guidance, Beta-catenin independent WNT signaling, Cargo recognition for clathrin-mediated endocytosis, Clathrin-mediated endocytosis, Developmental Biology, Endocrine and other factor-regulated calcium reabsorption - Mus musculus (mouse), Endocytosis - Mus musculus (mouse), Glutamate binding, activation of AMPA receptors and synaptic plasticity, Huntington disease - Mus musculus (mouse), Immune System, L1CAM interactions, LDL clearance, MHC class II antigen presentation, Membrane Trafficking, Nervous system development, Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, PCP/CE pathway, Plasma lipoprotein assembly, remodeling, and clearance, Plasma lipoprotein clearance, Recycling pathway of L1, Retrograde neurotrophin signalling, Signal Transduction, Signaling by NTRK1 (TRKA), Signaling by NTRKs, Signaling by Receptor Tyrosine Kinases, Signaling by WNT, Synaptic vesicle cycle - Mus musculus (mouse), Trafficking of AMPA receptors, Trafficking of GluR2-containing AMPA receptors, Transmission across Chemical Synapses, Transport of small molecules, VLDLR internalisation and degradation, Vesicle-mediated transport, WNT5A-dependent internalization of FZD2, FZD5 and ROR2, WNT5A-dependent internalization of FZD4
UniProt: P62743
Entrez ID: 232910
|
Does Knockout of Oas1e in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,283
|
Knockout
|
Oas1e
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Oas1e (2'-5' oligoadenylate synthetase 1E)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: antiviral innate immune response, cellular response to exogenous dsRNA, cellular response to interferon-alpha, cellular response to interferon-beta, defense response to bacterium, defense response to virus, glucose homeostasis, glucose metabolic process, interleukin-27-mediated signaling pathway, negative regulation of IP-10 production, negative regulation of chemokine (C-X-C motif) ligand 2 production, negative regulation of type I interferon-mediated signaling pathway, negative regulation of viral genome replication, positive regulation of cellular respiration, positive regulation of interferon-beta production, positive regulation of monocyte chemotactic protein-1 production, positive regulation of tumor necrosis factor production, protein complex oligomerization, response to virus, surfactant homeostasis, toll-like receptor 3 signaling pathway, toll-like receptor 4 signaling pathway, type I interferon-mediated signaling pathway; MF: 2'-5'-oligoadenylate synthetase activity, RNA binding, double-stranded RNA binding, nucleotidyltransferase activity; CC: cytoplasm, cytosol, membrane, mitochondrion, nucleoplasm, nucleus, ribosome
Pathways:
UniProt: A0A0J9YV76, Q8C2W3, A0A0J9YV17
Entrez ID: 231699
|
Does Knockout of Smg6 in Microglial Cell Line causally result in response to virus?
| 0
| 1,438
|
Knockout
|
Smg6
|
response to virus
|
Microglial Cell Line
|
Gene: Smg6 (SMG6 nonsense mediated mRNA decay factor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of telomere capping, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, regulation of telomere maintenance; MF: DNA binding, DNA polymerase binding, RNA binding, RNA endonuclease activity, endonuclease activity, hydrolase activity, metal ion binding, nuclease activity, ribonucleoprotein complex binding, telomerase RNA binding, telomeric DNA binding; CC: chromosome, chromosome, telomeric region, ciliary basal body, cytoplasm, cytosol, exon-exon junction complex, nucleolus, nucleus, plasma membrane, telomerase holoenzyme complex
Pathways: Metabolism of RNA, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), mRNA surveillance pathway - Mus musculus (mouse)
UniProt: P61406
Entrez ID: 103677
|
Does Knockout of Gsg1 in Microglial Cell Line causally result in cell proliferation?
| 0
| 1,359
|
Knockout
|
Gsg1
|
cell proliferation
|
Microglial Cell Line
|
Gene: Gsg1 (germ cell associated 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: RNA polymerase binding, protein binding; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, plasma membrane
Pathways:
UniProt: Q8R1W2
Entrez ID: 14840
|
Does Knockout of Retnlb in pro-B-lymphocyte causally result in response to chemicals?
| 0
| 1,720
|
Knockout
|
Retnlb
|
response to chemicals
|
pro-B-lymphocyte
|
Gene: Retnlb (resistin like beta)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: response to bacterium, signal transduction; CC: extracellular region, extracellular space
Pathways:
UniProt: Q99P86
Entrez ID: 57263
|
Does Knockout of Adap2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,260
|
Knockout
|
Adap2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Adap2 (ArfGAP with dual PH domains 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: heart development; MF: 1-phosphatidylinositol binding, GTPase activator activity, inositol 1,3,4,5 tetrakisphosphate binding, metal ion binding, phosphatidylinositol bisphosphate binding, phosphatidylinositol-3,4,5-trisphosphate binding, phosphatidylinositol-3,4-bisphosphate binding, phosphatidylinositol-4,5-bisphosphate binding, zinc ion binding; CC: cytoplasm, intracellular membrane-bounded organelle, membrane, mitochondrial envelope, plasma membrane
Pathways: cyclic AMP biosynthesis
UniProt: Q8R2V5
Entrez ID: 216991
|
Does Knockout of Fam171b in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Fam171b
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Fam171b (family with sequence similarity 171, member B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, membrane, synapse
Pathways:
UniProt: Q14CH0
Entrez ID: 241520
|
Does Knockout of Lrrn4 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Lrrn4
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Lrrn4 (leucine rich repeat neuronal 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: long-term memory, visual learning; CC: membrane, plasma membrane
Pathways:
UniProt: P59383
Entrez ID: 320974
|
Does Knockout of Mis12 in Embryonic Fibroblast Cell Line causally result in cell proliferation?
| 1
| 345
|
Knockout
|
Mis12
|
cell proliferation
|
Embryonic Fibroblast Cell Line
|
Gene: Mis12 (MIS12 kinetochore complex component)
Type: protein-coding
Summary: Predicted to be involved in attachment of mitotic spindle microtubules to kinetochore and kinetochore assembly. Predicted to be located in kinetochore and nucleus. Predicted to be part of MIS12/MIND type complex. Orthologous to human MIS12 (MIS12 kinetochore complex component). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: attachment of mitotic spindle microtubules to kinetochore, attachment of spindle microtubules to kinetochore, cell division, chromosome segregation, kinetochore assembly, mitotic cell cycle, mitotic sister chromatid segregation; CC: MIS12/MIND type complex, chromosome, chromosome, centromeric region, kinetochore, nucleus, outer kinetochore, spindle pole
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, EML4 and NUDC in mitotic spindle formation, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, RHO GTPase Effectors, RHO GTPases Activate Formins, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q9CY25
Entrez ID: 67139
|
Does Knockout of Dok6 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Dok6
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Dok6 (docking protein 6)
Type: protein-coding
Summary: Predicted to be involved in cell surface receptor protein tyrosine kinase signaling pathway. Predicted to be active in cytoplasm. Is expressed in several structures, including central nervous system; dorsal root ganglion; and ureteric tip. Orthologous to human DOK6 (docking protein 6). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology:
Pathways: Axon guidance, Developmental Biology, Nervous system development, RET signaling
UniProt: Q2MHE5
Entrez ID: 623279
|
Does Knockout of Ghdc in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Ghdc
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Ghdc (GH3 domain containing)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cytoplasm, endoplasmic reticulum, nuclear envelope, nucleus
Pathways: Immune System, Innate Immune System, Neutrophil degranulation
UniProt: Q99J23
Entrez ID: 80860
|
Does Knockout of Gm10355 in Microglial Cell Line causally result in response to virus?
| 0
| 2,429
|
Knockout
|
Gm10355
|
response to virus
|
Microglial Cell Line
|
Gene: Gm10355 (predicted gene 10355)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID:
|
Does Knockout of Cyp4f40 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Cyp4f40
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Cyp4f40 (cytochrome P450, family 4, subfamily f, polypeptide 40)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: arachidonate metabolic process, fatty acid metabolic process, leukotriene B4 catabolic process; MF: alkane 1-monooxygenase activity, alpha-tocopherol omega-hydroxylase activity, arachidonate epoxygenase activity, arachidonate monooxygenase activity, arachidonate omega-hydroxylase activity, fatty acid binding, heme binding, iron ion binding, leukotriene-B4 20-monooxygenase activity, long-chain fatty acid omega-hydroxylase activity, metal ion binding, monooxygenase activity, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen; CC: apical plasma membrane, cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Arachidonate metabolism, Biological oxidations, Cytochrome P450 - arranged by substrate type, Eicosanoids, Fatty acid metabolism, Fatty acids, Metabolism, Metabolism of lipids, Miscellaneous substrates, Phase I - Functionalization of compounds, Synthesis of Leukotrienes (LT) and Eoxins (EX)
UniProt: G3UW81
Entrez ID: 631304
|
Does Knockout of Zfp729a in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
Zfp729a
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Zfp729a (zinc finger protein 729a)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription repressor activity, RNA polymerase II-specific, metal ion binding, zinc ion binding; CC: nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Mus musculus (mouse), RNA Polymerase II Transcription
UniProt: Q4QQP3
Entrez ID: 212281
|
Does Knockout of Krtap26-1 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Krtap26-1
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Krtap26-1 (keratin associated protein 26-1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: molecular_function, structural molecule activity; CC: cellular_component, cytosol, intermediate filament, keratin filament
Pathways:
UniProt: Q9D7N2
Entrez ID: 69533
|
Does Knockout of Exosc4 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Exosc4
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Exosc4 (exosome component 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA deamination, RNA catabolic process, RNA processing, U4 snRNA 3'-end processing, defense response to virus, gene expression, histone mRNA catabolic process, maturation of 5.8S rRNA, nuclear mRNA surveillance, nuclear-transcribed mRNA catabolic process, poly(A)-dependent snoRNA 3'-end processing, positive regulation of cell growth, rRNA catabolic process, rRNA processing; MF: RNA binding, mRNA 3'-UTR AU-rich region binding, protein binding; CC: cytoplasm, cytoplasmic exosome (RNase complex), cytosol, euchromatin, exosome (RNase complex), nuclear exosome (RNase complex), nucleolar exosome (RNase complex), nucleolus, nucleoplasm, nucleus
Pathways: Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA, Deadenylation-dependent mRNA decay, KSRP (KHSRP) binds and destabilizes mRNA, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Nuclear RNA decay, RNA degradation - Mus musculus (mouse), Regulation of mRNA stability by proteins that bind AU-rich elements, Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA, mRNA decay by 3' to 5' exoribonuclease, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q921I9
Entrez ID: 109075
|
Does Knockout of Nop14 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 84
|
Knockout
|
Nop14
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Nop14 (NOP14 nucleolar protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: maturation of SSU-rRNA, rRNA processing, ribosomal small subunit biogenesis, ribosome biogenesis; MF: enzyme binding, snoRNA binding; CC: Noc4p-Nop14p complex, nucleolus, nucleoplasm, nucleus, small-subunit processome
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q8R3N1
Entrez ID: 75416
|
Does Knockout of Il23r in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,272
|
Knockout
|
Il23r
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Il23r (interleukin 23 receptor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell surface receptor signaling pathway via JAK-STAT, cytokine-mediated signaling pathway, immune system process, inflammatory response, innate immune response, interleukin-23-mediated signaling pathway, leukocyte mediated immunity, negative regulation of interleukin-10 production, positive regulation of T-helper 1 type immune response, positive regulation of cell population proliferation, positive regulation of defense response to virus by host, positive regulation of interleukin-12 production, positive regulation of type II interferon production, prolactin signaling pathway, response to lipopolysaccharide, response to type II interferon; MF: cytokine binding, cytokine receptor activity, interleukin-12 receptor binding, interleukin-23 binding, interleukin-23 receptor activity, peptide hormone binding, prolactin receptor activity; CC: cell surface, external side of plasma membrane, interleukin-23 receptor complex, membrane, plasma membrane, receptor complex
Pathways: Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Mus musculus (mouse), Immune System, Inflammatory bowel disease - Mus musculus (mouse), Interleukin-12 family signaling, Interleukin-23 signaling, JAK-STAT signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Signaling by Interleukins, Th17 cell differentiation - Mus musculus (mouse)
UniProt: Q8K4B4
Entrez ID: 209590
|
Does Knockout of Rassf4 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,263
|
Knockout
|
Rassf4
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Rassf4 (Ras association (RalGDS/AF-6) domain family member 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: signal transduction
Pathways: Hippo signaling pathway - multiple species - Mus musculus (mouse)
UniProt: Q8CB96
Entrez ID: 213391
|
Does Knockout of Gtf2h2 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Gtf2h2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Gtf2h2 (general transcription factor II H, polypeptide 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, DNA-templated transcription, nucleotide-excision repair, regulation of transcription by RNA polymerase II, transcription by RNA polymerase II; MF: RNA polymerase II general transcription initiation factor activity, metal ion binding, zinc ion binding; CC: core TFIIH complex portion of holo TFIIH complex, nuclear speck, nucleus, transcription factor TFIID complex, transcription factor TFIIH core complex, transcription factor TFIIH holo complex
Pathways: Basal transcription factors - Mus musculus (mouse), DNA Repair, Dual Incision in GG-NER, Dual incision in TC-NER, Formation of Incision Complex in GG-NER, Formation of RNA Pol II elongation complex , Formation of TC-NER Pre-Incision Complex, Formation of the Early Elongation Complex, Gap-filling DNA repair synthesis and ligation in TC-NER, Gene expression (Transcription), Generic Transcription Pathway, Global Genome Nucleotide Excision Repair (GG-NER), Metabolism of RNA, Nucleotide Excision Repair, Nucleotide excision repair - Mus musculus (mouse), RNA Pol II CTD phosphorylation and interaction with CE, RNA Polymerase I Promoter Clearance, RNA Polymerase I Promoter Escape, RNA Polymerase I Transcription, RNA Polymerase I Transcription Initiation, RNA Polymerase I Transcription Termination, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Promoter Escape, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, RNA Polymerase II Transcription Initiation, RNA Polymerase II Transcription Initiation And Promoter Clearance, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, TP53 Regulates Transcription of DNA Repair Genes, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Transcriptional Regulation by TP53, Viral carcinogenesis - Mus musculus (mouse), mRNA Capping
UniProt: Q9JIB4
Entrez ID: 23894
|
Does Knockout of Gnb1l in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,267
|
Knockout
|
Gnb1l
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Gnb1l (guanine nucleotide binding protein (G protein), beta polypeptide 1-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage checkpoint signaling, DNA damage response, social behavior; CC: cytoplasm, nucleus
Pathways:
UniProt: Q9EQ15
Entrez ID: 13972
|
Does Knockout of Kansl1 in Pancreatic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,196
|
Knockout
|
Kansl1
|
protein/peptide accumulation
|
Pancreatic Cell Line
|
Gene: Kansl1 (KAT8 regulatory NSL complex subunit 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, positive regulation of DNA-templated transcription, regulation of mitochondrial transcription; CC: H4 histone acetyltransferase complex, MLL1 complex, NSL complex, chromosome, chromosome, centromeric region, cytoplasm, cytoskeleton, histone acetyltransferase complex, kinetochore, microtubule, mitochondrion, nucleoplasm, nucleus, spindle pole
Pathways: Chromatin modifying enzymes, Chromatin organization, Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of gene expression, Formation of WDR5-containing histone-modifying complexes, Gene expression (Transcription), HATs acetylate histones
UniProt: Q80TG1
Entrez ID: 76719
|
Does Knockout of Myh14 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Myh14
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Myh14 (myosin, heavy polypeptide 14)
Type: protein-coding
Summary: Enables several functions, including ATP binding activity; actin filament binding activity; and microfilament motor activity. Acts upstream of or within actin filament-based movement. Located in several cellular components, including brush border; growth cone; and stress fiber. Part of myosin complex. Is expressed in several structures, including alimentary system; central nervous system; respiratory system; sensory organ; and vibrissa. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 4A and sensorineural hearing loss. Orthologous to human MYH14 (myosin heavy chain 14). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: actin filament-based movement, actin filament-based process, actomyosin structure organization, mitochondrion organization, mitotic cytokinesis, neuronal action potential, regulation of cell shape, sensory perception of sound, skeletal muscle contraction, skeletal muscle tissue development, vocalization behavior; MF: ATP binding, actin binding, actin filament binding, calmodulin binding, cytoskeletal motor activity, cytoskeletal protein binding, microfilament motor activity, molecular adaptor activity, nucleotide binding; CC: actomyosin, axon, brush border, cytoplasm, growth cone, myelin sheath, myosin II complex, myosin II filament, myosin complex, myosin filament, stress fiber
Pathways: RHO GTPase Effectors, RHO GTPases activate PAKs, Regulation of actin cytoskeleton - Mus musculus (mouse), Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Tight junction - Mus musculus (mouse), Vascular smooth muscle contraction - Mus musculus (mouse)
UniProt: Q6URW6
Entrez ID: 71960
|
Does Knockout of Irs2 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,273
|
Knockout
|
Irs2
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Irs2 (insulin receptor substrate 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: brain development, cellular response to endothelin, cellular response to glucose stimulus, cellular response to insulin stimulus, epithelial cell migration, insulin receptor signaling pathway, insulin-like growth factor receptor signaling pathway, mammary gland development, negative regulation of B cell apoptotic process, negative regulation of long-chain fatty acid import across plasma membrane, positive regulation of B cell proliferation, positive regulation of D-glucose import, positive regulation of cell population proliferation, positive regulation of epithelial cell migration, positive regulation of fatty acid beta-oxidation, positive regulation of glucose metabolic process, positive regulation of glycogen biosynthetic process, positive regulation of insulin secretion, positive regulation of mesenchymal cell proliferation, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of transport, positive regulation of type B pancreatic cell proliferation, response to glucose, signal transduction; MF: 14-3-3 protein binding, insulin receptor binding, phosphatidylinositol 3-kinase activator activity, phosphatidylinositol 3-kinase binding, protein binding, protein domain specific binding, protein kinase binding, protein phosphatase binding, protein-macromolecule adaptor activity, signaling adaptor activity, transmembrane receptor protein tyrosine kinase adaptor activity; CC: cytoplasm, cytosol, plasma membrane
Pathways: AMPK signaling pathway - Mus musculus (mouse), Adipocytokine signaling pathway - Mus musculus (mouse), Alzheimer disease - Mus musculus (mouse), Autophagy - animal - Mus musculus (mouse), Axon guidance, Cytokine Signaling in Immune system, Developmental Biology, Erythropoietin activates Phosphoinositide-3-kinase (PI3K), Erythropoietin activates RAS, FoxO signaling pathway - Mus musculus (mouse), Growth hormone synthesis, secretion and action - Mus musculus (mouse), IGF1R signaling cascade, IRS activation, IRS-mediated signalling, IRS-related events triggered by IGF1R, Immune System, Insulin receptor signalling cascade, Insulin resistance - Mus musculus (mouse), Insulin signaling pathway - Mus musculus (mouse), Interleukin-7 signaling, Intracellular signaling by second messengers, Longevity regulating pathway - Mus musculus (mouse), Longevity regulating pathway - multiple species - Mus musculus (mouse), MAPK family signaling cascades, MAPK1/MAPK3 signaling, MicroRNAs in cancer - Mus musculus (mouse), Negative regulation of the PI3K/AKT network, Nervous system development, Non-alcoholic fatty liver disease - Mus musculus (mouse), PI3K Cascade, PI3K/AKT activation, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, PIP3 activates AKT signaling, RAF/MAP kinase cascade, RET signaling, Regulation of lipolysis in adipocytes - Mus musculus (mouse), SOS-mediated signalling, Signal Transduction, Signal attenuation, Signaling by Erythropoietin, Signaling by Insulin receptor, Signaling by Interleukins, Signaling by NTRK1 (TRKA), Signaling by NTRKs, Signaling by Receptor Tyrosine Kinases, Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), Type II diabetes mellitus - Mus musculus (mouse), cGMP-PKG signaling pathway - Mus musculus (mouse)
UniProt: P81122
Entrez ID: 384783
|
Does Knockout of Krtap22-2 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Krtap22-2
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Krtap22-2 (keratin associated protein 22-2)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: J3QNX6
Entrez ID: 68740
|
Does Knockout of Catsper1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,279
|
Knockout
|
Catsper1
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Catsper1 (cation channel, sperm associated 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: calcium ion transmembrane transport, calcium ion transport, cell differentiation, flagellated sperm motility, fusion of sperm to egg plasma membrane involved in single fertilization, monoatomic ion transmembrane transport, monoatomic ion transport, regulation of calcium ion transport, regulation of cilium beat frequency involved in ciliary motility, spermatogenesis, transmembrane transport; MF: calcium channel activity, calcium-activated cation channel activity, monoatomic ion channel activity, protein binding, voltage-gated calcium channel activity; CC: CatSper complex, cell projection, cilium, membrane, monoatomic ion channel complex, motile cilium, plasma membrane, sperm flagellum, sperm principal piece
Pathways: Fertilization, Reproduction, Sperm Motility And Taxes
UniProt: Q91ZR5
Entrez ID: 225865
|
Does Knockout of Syt14 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Syt14
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Syt14 (synaptotagmin XIV)
Type: protein-coding
Summary: This gene encodes a member of the synaptotagmin family. The encoded protein may be involved in membrane trafficking. Disruption of a similar gene in human has been associated with autosomal recessive spinocerebellar ataxia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014].
Gene Ontology: MF: identical protein binding, phospholipid binding, protein binding; CC: membrane
Pathways:
UniProt: Q7TN84
Entrez ID: 329324
|
Does Knockout of Ccdc88b in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,838
|
Knockout
|
Ccdc88b
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Ccdc88b (coiled-coil domain containing 88B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic microtubule organization, cytoskeleton-dependent intracellular transport, defense response to protozoan, positive regulation of T cell activation, positive regulation of T cell proliferation, positive regulation of cytokine production; MF: dynein light intermediate chain binding, microtubule binding, protein binding; CC: Golgi apparatus, centrosome, cytoplasm, cytoskeleton, cytosol, endoplasmic reticulum, membrane, microtubule organizing center, nucleoplasm
Pathways:
UniProt: Q4QRL3
Entrez ID: 78317
|
Does Knockout of Dhrs13 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Dhrs13
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Dhrs13 (dehydrogenase/reductase 13)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q5SS80
Entrez ID: 70451
|
Does Knockout of Tgm6 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Tgm6
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Tgm6 (transglutaminase 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: acyltransferase activity, metal ion binding, protein-glutamine gamma-glutamyltransferase activity, transferase activity; CC: cytoplasm
Pathways:
UniProt: Q14CG3, Q8BM11
Entrez ID: 241636
|
Does Knockout of Rhox6 in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Rhox6
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Rhox6 (reproductive homeobox 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, positive regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific; CC: cellular_component, nucleus
Pathways:
UniProt: O70238
Entrez ID: 19202
|
Does Knockout of Adal in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Adal
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Adal (adenosine deaminase-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adenosine catabolic process, inosine biosynthetic process, nucleotide metabolic process, response to alcohol; MF: N6-methyl-AMP deaminase activity, adenosine deaminase activity, deaminase activity, hydrolase activity, metal ion binding
Pathways: Abacavir ADME, Abacavir metabolism, Drug ADME, Metabolism, Metabolism of nucleotides, Nucleotide salvage, Purine salvage
UniProt: Q80SY6
Entrez ID: 75894
|
Does Knockout of Ppp6c in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,290
|
Knockout
|
Ppp6c
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Ppp6c (protein phosphatase 6, catalytic subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G1/S transition of mitotic cell cycle, cGAS/STING signaling pathway, immune system process, innate immune response, negative regulation of cGAS/STING signaling pathway; MF: hydrolase activity, metal ion binding, phosphoprotein phosphatase activity, protein serine/threonine phosphatase activity; CC: cytoplasm, cytosol, mitochondrion
Pathways: Asparagine N-linked glycosylation, COPII-mediated vesicle transport, Cell Cycle, Chromosome Maintenance, ER to Golgi Anterograde Transport, Extension of Telomeres, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, Telomere Extension By Telomerase, Telomere Maintenance, Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: Q9CQR6
Entrez ID: 67857
|
Does Knockout of A3galt2 in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
A3galt2
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: A3galt2 (alpha 1,3-galactosyltransferase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: carbohydrate metabolic process, cellular response to manganese ion, glycosphingolipid biosynthetic process, lipid metabolic process; MF: N-acetyllactosaminide 3-alpha-galactosyltransferase activity, alpha-1,3-galactosyltransferase activity, glycosyltransferase activity, hexosyltransferase activity, metal ion binding, transferase activity; CC: Golgi apparatus, Golgi cisterna membrane, membrane, vesicle
Pathways: Glycosphingolipid biosynthesis - globo and isoglobo series - Mus musculus (mouse)
UniProt: Q3V1N9
Entrez ID: 215493
|
Does Knockout of Mrps15 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Mrps15
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Mrps15 (mitochondrial ribosomal protein S15)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial translation, translation; MF: protein binding, structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial matrix, mitochondrial ribosome, mitochondrial small ribosomal subunit, mitochondrion, nucleolus, nucleoplasm, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Ribosome - Mus musculus (mouse), Translation
UniProt: Q9DC71
Entrez ID: 66407
|
Does Knockout of Elmod2 in breast epithelium causally result in cell cycle progression?
| 0
| 1,469
|
Knockout
|
Elmod2
|
cell cycle progression
|
breast epithelium
|
Gene: Elmod2 (ELMO/CED-12 domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of defense response to virus; MF: GTPase activator activity
Pathways:
UniProt: Q8BGF6
Entrez ID: 244548
|
Does Knockout of Runx1t1 in Embryonic Fibroblast Cell Line causally result in cell proliferation?
| 0
| 345
|
Knockout
|
Runx1t1
|
cell proliferation
|
Embryonic Fibroblast Cell Line
|
Gene: Runx1t1 (RUNX1 translocation partner 1)
Type: protein-coding
Summary: Enables identical protein binding activity. Involved in negative regulation of fat cell differentiation. Acts upstream of or within fat cell differentiation and regulation of DNA-templated transcription. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human RUNX1T1 (RUNX1 partner transcriptional co-repressor 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: DNA-templated transcription, fat cell differentiation, negative regulation of DNA-templated transcription, negative regulation of fat cell differentiation, negative regulation of neuron projection development, regulation of DNA-templated transcription; MF: DNA-binding transcription factor binding, identical protein binding, metal ion binding, protein binding, transcription corepressor activity, zinc ion binding; CC: nuclear matrix, nucleoplasm, nucleus, transcription repressor complex
Pathways: Acute myeloid leukemia - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Transcriptional misregulation in cancer - Mus musculus (mouse)
UniProt: Q61909
Entrez ID: 12395
|
Does Knockout of Fbxo7 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,275
|
Knockout
|
Fbxo7
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Fbxo7 (F-box protein 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagy of mitochondrion, negative regulation of G1/S transition of mitotic cell cycle, negative regulation of lymphocyte differentiation, negative regulation of neuron apoptotic process, negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway, positive regulation of autophagy of mitochondrion, positive regulation of mitophagy, proteasome-mediated ubiquitin-dependent protein catabolic process, protein K48-linked ubiquitination, protein targeting to mitochondrion, protein ubiquitination, regulation of locomotion, regulation of neuron projection development, regulation of protein stability, ubiquitin-dependent protein catabolic process; MF: protein heterodimerization activity, protein kinase binding, ubiquitin binding, ubiquitin protein ligase binding, ubiquitin-like ligase-substrate adaptor activity; CC: Lewy body core, Lewy body corona, Lewy neurite, SCF ubiquitin ligase complex, classical Lewy body, cytoplasm, cytosol, glial cytoplasmic inclusion, mitochondrion, nucleoplasm, nucleus, protein-containing complex, ubiquitin ligase complex
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System, Metabolism of proteins, Neddylation, Post-translational protein modification
UniProt: Q3U7U3
Entrez ID: 69754
|
Does Knockout of Hspa8 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,283
|
Knockout
|
Hspa8
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Hspa8 (heat shock protein 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ATP metabolic process, G1/S transition of mitotic cell cycle, RNA splicing, autophagy, axo-dendritic transport, cellular response to cadmium ion, cellular response to heat, cellular response to hydrogen peroxide, cerebellum development, chaperone-mediated autophagy, chaperone-mediated autophagy translocation complex disassembly, clathrin coat disassembly, estrous cycle, forebrain development, host-mediated activation of viral genome replication, host-mediated perturbation of viral process, kidney development, late endosomal microautophagy, mRNA processing, mRNA splicing, via spliceosome, maintenance of postsynaptic specialization structure, negative regulation of DNA-templated transcription, negative regulation of NLRP3 inflammasome complex assembly, negative regulation of cardiac muscle cell apoptotic process, negative regulation of supramolecular fiber organization, positive regulation of T cell mediated cytotoxicity, positive regulation of cell migration, positive regulation of ferroptosis, positive regulation of gene expression, positive regulation of lysosomal membrane permeability, positive regulation of mRNA splicing, via spliceosome, positive regulation of phagocytosis, positive regulation of protein refolding, positive regulation of proteolysis, protein catabolic process, protein folding, protein import into nucleus, protein refolding, protein targeting to lysosome involved in chaperone-mediated autophagy, protein transmembrane import into intracellular organelle, protein-containing complex disassembly, regulation of cell cycle, regulation of postsynapse organization, regulation of protein complex stability, regulation of protein stability, response to activity, response to estradiol, response to ethanol, response to nickel cation, response to odorant, response to progesterone, response to starvation, response to xenobiotic stimulus, skeletal muscle tissue development, slow axonal transport; MF: A1 adenosine receptor binding, ADP binding, ATP binding, ATP hydrolysis activity, ATP-dependent protein disaggregase activity, ATP-dependent protein folding chaperone, C3HC4-type RING finger domain binding, G protein-coupled receptor binding, RNA binding, clathrin-uncoating ATPase activity, enzyme binding, heat shock protein binding, hydrolase activity, lipid binding, nucleotide binding, peptide binding, phosphatidylserine binding, prostaglandin binding, protein binding, protein folding chaperone, protein-folding chaperone binding, protein-macromolecule adaptor activity, receptor ligand activity, signaling receptor binding, ubiquitin protein ligase binding, unfolded protein binding; CC: Prp19 complex, asymmetric synapse, autophagosome, axon, cell surface, cytoplasm, cytosol, dendrite, dendritic shaft, dendritic spine, extracellular exosome, extracellular space, glutamatergic synapse, glycinergic synapse, intermediate filament, late endosome, late endosome lumen, lysosomal matrix, lysosomal membrane, lysosome, melanosome, membrane, microtubule, myelin sheath, neuron spine, neuronal cell body, nucleolus, nucleus, perikaryon, perinuclear region of cytoplasm, photoreceptor inner segment, photoreceptor ribbon synapse, plasma membrane, postsynapse, postsynaptic density, postsynaptic specialization membrane, presynapse, protein folding chaperone complex, protein-containing complex, ribonucleoprotein complex, spliceosomal complex, synaptic vesicle, terminal bouton
Pathways: AUF1 (hnRNP D0) binds and destabilizes mRNA, Antigen processing and presentation - Mus musculus (mouse), Antiviral mechanism by IFN-stimulated genes, Attenuation phase, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Clathrin-mediated endocytosis, Cytokine Signaling in Immune system, Endocytosis - Mus musculus (mouse), Estrogen signaling pathway - Mus musculus (mouse), GABA synthesis, release, reuptake and degradation, Golgi Associated Vesicle Biogenesis, HSF1-dependent transactivation, HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand, Immune System, Innate Immune System, Interferon Signaling, Legionellosis - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), Longevity regulating pathway - multiple species - Mus musculus (mouse), Lysosome Vesicle Biogenesis, MAPK signaling pathway - Mus musculus (mouse), Measles - Mus musculus (mouse), Membrane Trafficking, Metabolism of RNA, Metabolism of proteins, Neuronal System, Neurotransmitter release cycle, Neutrophil degranulation, PKR-mediated signaling, Post-translational protein modification, Prion disease - Mus musculus (mouse), Processing of Capped Intron-Containing Pre-mRNA, Protein methylation, Protein processing in endoplasmic reticulum - Mus musculus (mouse), Regulation of HSF1-mediated heat shock response, Regulation of mRNA stability by proteins that bind AU-rich elements, Spliceosome - Mus musculus (mouse), Toxoplasmosis - Mus musculus (mouse), Transmission across Chemical Synapses, Vesicle-mediated transport, mRNA Splicing, mRNA Splicing - Major Pathway, trans-Golgi Network Vesicle Budding
UniProt: P63017
Entrez ID: 15481
|
Does Knockout of Cabp5 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,683
|
Knockout
|
Cabp5
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Cabp5 (calcium binding protein 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: calcium channel regulator activity, calcium ion binding, metal ion binding; CC: cytoplasm, cytosol
Pathways:
UniProt: Q9JLK3
Entrez ID: 29865
|
Does Knockout of Tmem200a in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
Tmem200a
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Tmem200a (transmembrane protein 200A)
Type: protein-coding
Summary: Predicted to be located in membrane. Orthologous to human TMEM200A (transmembrane protein 200A). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: CC: cellular_component, membrane
Pathways:
UniProt: Q8C817
Entrez ID: 77220
|
Does Knockout of Marcksl1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
Marcksl1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Marcksl1 (MARCKS-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin filament organization, central nervous system development, positive regulation of cell population proliferation, regulation of presynaptic cytosolic calcium ion concentration; MF: actin binding, actin filament binding, calmodulin binding; CC: cytoplasm, cytoskeleton, membrane, plasma membrane, presynaptic cytosol, presynaptic membrane, synaptic vesicle
Pathways: Fc gamma R-mediated phagocytosis - Mus musculus (mouse), Leishmaniasis - Mus musculus (mouse)
UniProt: P28667
Entrez ID: 17357
|
Does Knockout of Toporsl in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,565
|
Knockout
|
Toporsl
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Toporsl (topoisomerase I binding, arginine/serine-rich like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein monoubiquitination, protein polyubiquitination; MF: transferase activity, ubiquitin protein ligase activity
Pathways:
UniProt: Q9D2F8
Entrez ID: 68274
|
Does Knockout of Prrc2a in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Prrc2a
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Prrc2a (proline-rich coiled-coil 2A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cytoplasm, cytosol, nucleoplasm, nucleus, plasma membrane
Pathways:
UniProt: Q7TSC1
Entrez ID: 53761
|
Does Knockout of Slc4a4 in Pancreatic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,196
|
Knockout
|
Slc4a4
|
protein/peptide accumulation
|
Pancreatic Cell Line
|
Gene: Slc4a4 (solute carrier family 4 (anion exchanger), member 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: bicarbonate transport, establishment of localization in cell, inorganic anion transport, monoatomic anion transmembrane transport, monoatomic anion transport, monoatomic ion transport, positive regulation of glycolytic process, regulation of intracellular pH, regulation of membrane potential, regulation of pH, sodium ion export across plasma membrane, sodium ion transmembrane transport, sodium ion transport, transmembrane transport; MF: identical protein binding, monoatomic anion transmembrane transporter activity, protein binding, sodium:bicarbonate symporter activity, solute:inorganic anion antiporter activity, symporter activity; CC: basolateral plasma membrane, cell surface, cytosol, membrane, plasma membrane
Pathways: Bicarbonate transporters, Bile secretion - Mus musculus (mouse), Pancreatic secretion - Mus musculus (mouse), Proximal tubule bicarbonate reclamation - Mus musculus (mouse), SLC-mediated transmembrane transport, SLC-mediated transport of inorganic anions, Transport of small molecules
UniProt: O88343
Entrez ID: 54403
|
Does Knockout of Josd2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,259
|
Knockout
|
Josd2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Josd2 (Josephin domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein deubiquitination, proteolysis; MF: cysteine-type deubiquitinase activity, deubiquitinase activity, hydrolase activity, peptidase activity; CC: cellular_component, cytoplasm, cytosol
Pathways: Deubiquitination, Josephin domain DUBs, Metabolism of proteins, Post-translational protein modification
UniProt: Q9CR30
Entrez ID: 66124
|
Does Knockout of Rcc1l in Regulatory T cell causally result in cell proliferation?
| 0
| 1,484
|
Knockout
|
Rcc1l
|
cell proliferation
|
Regulatory T cell
|
Gene: Rcc1l (reculator of chromosome condensation 1 like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial fusion, mitochondrial large ribosomal subunit assembly, mitochondrial small ribosomal subunit assembly; MF: guanyl-nucleotide exchange factor activity, protein binding, rRNA binding; CC: membrane, mitochondrial inner membrane, mitochondrial matrix, mitochondrial membrane, mitochondrion
Pathways:
UniProt: Q9CYF5
Entrez ID: 94254
|
Does Knockout of Nap1l3 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,268
|
Knockout
|
Nap1l3
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Nap1l3 (nucleosome assembly protein 1-like 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: nucleosome assembly; MF: chromatin binding, histone binding; CC: chromatin, cytoplasm, nucleus
Pathways:
UniProt: Q794H2
Entrez ID: 54561
|
Does Knockout of Lipt2 in Microglial Cell Line causally result in response to virus?
| 0
| 1,438
|
Knockout
|
Lipt2
|
response to virus
|
Microglial Cell Line
|
Gene: Lipt2 (lipoyl(octanoyl) transferase 2 (putative))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of oxygen metabolic process, protein lipoylation; MF: acyltransferase activity, ligase activity, lipoyl(octanoyl) transferase activity, protein binding, transferase activity; CC: mitochondrion
Pathways: Lipoic acid metabolism - Mus musculus (mouse), Metabolism of proteins, Post-translational protein modification, Protein lipoylation
UniProt: Q9D009
Entrez ID: 67164
|
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