prompt string | hit int64 | screen_id int64 | crispr_strategy string | gene string | phenotype string | cell_type string | gene_context string |
|---|---|---|---|---|---|---|---|
Does Knockout of Necab2 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,680 | Knockout | Necab2 | protein/peptide distribution | myoblast cell line | Gene: Necab2 (N-terminal EF-hand calcium binding protein 2)
Type: protein-coding
Summary: Predicted to enable A2A adenosine receptor binding activity; identical protein binding activity; and type 5 metabotropic glutamate receptor binding activity. Predicted to be involved in positive regulation of prote... |
Does Knockout of Dhcr7 in Immortal mouse chromaffin cells causally result in cell viability? | 0 | 2,469 | Knockout | Dhcr7 | cell viability | Immortal mouse chromaffin cells | Gene: Dhcr7 (7-dehydrocholesterol reductase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: blood vessel development, cholesterol biosynthetic process, cholesterol biosynthetic process via desmosterol, cholesterol biosynthetic process via lathosterol, cholesterol metabol... |
Does Knockout of Cyp2u1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 0 | 84 | Knockout | Cyp2u1 | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Cyp2u1 (cytochrome P450, family 2, subfamily u, polypeptide 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: lipid metabolic process, omega-hydroxylase P450 pathway, organic acid metabolic process, steroid metabolic process, xenobiotic metabolic process; MF: arach... |
Does Knockout of Slc22a15 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 0 | 83 | Knockout | Slc22a15 | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Slc22a15 (solute carrier family 22 (organic anion/cation transporter), member 15)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: amino acid transport, amino-acid betaine transport, monoatomic ion transport, transmembrane transport; MF: amino-acid betaine transmembr... |
Does Knockout of Vps26b in Colonic Cancer Cell Line causally result in tumorigenicity? | 0 | 2,177 | Knockout | Vps26b | tumorigenicity | Colonic Cancer Cell Line | Gene: Vps26b (VPS26 retromer complex component B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to type II interferon, intracellular protein transport, protein transport, regulation of neurotransmitter receptor localization to postsynaptic specializati... |
Does Knockout of Sfmbt2 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 1,565 | Knockout | Sfmbt2 | response to chemicals | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: Sfmbt2 (Scm-like with four mbt domains 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of DNA-templated transcription, negative regulation of gene expression, regulation of DNA-templated transcription; MF: chromatin binding, histone binding, t... |
Does Knockout of Zfp983 in Mouse cell causally result in protein/peptide accumulation? | 0 | 1,047 | Knockout | Zfp983 | protein/peptide accumulation | Mouse cell | Gene: Zfp983 (zinc finger protein 983)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, response to bacterium; MF: DNA binding, DNA-binding transcription factor activity, RNA polym... |
Does Knockout of Dpy19l2 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 2,308 | Knockout | Dpy19l2 | response to chemicals | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: Dpy19l2 (dpy-19 like 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, spermatid development, spermatogenesis; MF: glycosyltransferase activity, mannosyltransferase activity, protein binding, transferase activity; CC: membrane, nuclear inner m... |
Does Knockout of Stip1 in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 1,263 | Knockout | Stip1 | cell proliferation | Colonic Cancer Cell Line | Gene: Stip1 (stress-induced phosphoprotein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: Hsp70 protein binding, Hsp90 protein binding, protein binding, protein-folding chaperone binding; CC: cytoplasm, cytosol, dynein axonemal particle, myelin sheath, nucleus, protei... |
Does Knockout of Pnlip in Melanoma Cell Line causally result in cell proliferation? | 0 | 1,269 | Knockout | Pnlip | cell proliferation | Melanoma Cell Line | Gene: Pnlip (pancreatic lipase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cholesterol homeostasis, fatty acid biosynthetic process, high-density lipoprotein particle remodeling, intestinal cholesterol absorption, lipid catabolic process, lipid metabolic process, pos... |
Does Knockout of Lpar1 in Colonic Cancer Cell Line causally result in tumorigenicity? | 0 | 2,180 | Knockout | Lpar1 | tumorigenicity | Colonic Cancer Cell Line | Gene: Lpar1 (lysophosphatidic acid receptor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, Golgi to plasma membrane protein transport, adenylate cyclase-activating G protein-coupled receptor signaling pathway, adenylate cy... |
Does Knockout of Dchs2 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,285 | Knockout | Dchs2 | cell proliferation | Mouse kidney carcinoma cell | Gene: Dchs2 (dachsous cadherin related 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: branching involved in ureteric bud morphogenesis, cell adhesion, cell differentiation, cell-cell adhesion, condensed mesenchymal cell proliferation, digestive tract development, esta... |
Does Knockout of 4930555G01Rik in Melanoma Cell Line causally result in cell proliferation? | 0 | 1,838 | Knockout | 4930555G01Rik | cell proliferation | Melanoma Cell Line | Gene: 4930555G01Rik (RIKEN cDNA 4930555G01 gene)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: |
Does Knockout of Leng8 in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,278 | Knockout | Leng8 | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: Leng8 (leukocyte receptor cluster (LRC) member 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q8CBY3
Entrez ID: 232798 |
Does Knockout of Srek1ip1 in macrophage causally result in phagocytosis? | 0 | 1,889 | Knockout | Srek1ip1 | phagocytosis | macrophage | Gene: Srek1ip1 (splicing regulatory glutamine/lysine-rich protein 1interacting protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, biological_process, mRNA processing; MF: metal ion binding, molecular_function, nucleic acid binding, zinc ion binding
... |
Does Knockout of Crnkl1 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,272 | Knockout | Crnkl1 | cell proliferation | Mouse kidney carcinoma cell | Gene: Crnkl1 (crooked neck pre-mRNA splicing factor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA processing, RNA splicing, mRNA processing, mRNA splicing, via spliceosome, spliceosomal complex assembly; MF: RNA binding; CC: Prp19 complex, U2-type catalytic step ... |
Does Knockout of Ndufs1 in Pancreatic Cancer Cell Line causally result in response to chemicals? | 0 | 2,359 | Knockout | Ndufs1 | response to chemicals | Pancreatic Cancer Cell Line | Gene: Ndufs1 (NADH:ubiquinone oxidoreductase core subunit S1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ATP synthesis coupled electron transport, aerobic respiration, cellular respiration, mitochondrial electron transport, NADH to ubiquinone, mitochondrial respirato... |
Does Knockout of Ppp4r3a in Microglial Cell Line causally result in protein/peptide accumulation? | 0 | 1,399 | Knockout | Ppp4r3a | protein/peptide accumulation | Microglial Cell Line | Gene: Ppp4r3a (protein phosphatase 4 regulatory subunit 3A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, gluconeogenesis, positive regulation of gluconeogenesis, regulation of double-strand break repair; MF: protein binding, protein phosphatase act... |
Does Knockout of Vmn2r38 in Microglial Cell Line causally result in protein/peptide accumulation? | 0 | 1,399 | Knockout | Vmn2r38 | protein/peptide accumulation | Microglial Cell Line | Gene: Vmn2r38 (vomeronasal 2, receptor 38)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, signal transduction; MF: G protein-coupled receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: G3UYA... |
Does Knockout of Chil6 in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,261 | Knockout | Chil6 | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: Chil6 (chitinase-like 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: carbohydrate metabolic process, chitin catabolic process, positive regulation of chemokine production, production of molecular mediator involved in inflammatory response; MF: chitin binding, ch... |
Does Knockout of Xpo4 in Melanoma Cell Line causally result in cell proliferation? | 0 | 1,269 | Knockout | Xpo4 | cell proliferation | Melanoma Cell Line | Gene: Xpo4 (exportin 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: glycolytic process, nuclear transport, positive regulation of protein export from nucleus, protein export from nucleus, protein transport; MF: nuclear export signal receptor activity, small GTPase bin... |
Does Knockout of Trim17 in Regulatory T cell causally result in cell proliferation? | 0 | 2,127 | Knockout | Trim17 | cell proliferation | Regulatory T cell | Gene: Trim17 (tripartite motif-containing 17)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagy, innate immune response, protein autoubiquitination, protein ubiquitination, regulation of gene expression, regulation of protein localization; MF: metal ion binding, p... |
Does Knockout of Tmprss9 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity? | 0 | 688 | Knockout | Tmprss9 | tumorigenicity | Immortal Mouse Liver-derived Cell Line | Gene: Tmprss9 (transmembrane protease, serine 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: plasminogen activation, proteolysis; MF: hydrolase activity, peptidase activity, serine-type endopeptidase activity, serine-type peptidase activity; CC: membrane, plasma membr... |
Does Knockout of Rpusd4 in breast epithelium causally result in cell cycle progression? | 0 | 1,470 | Knockout | Rpusd4 | cell cycle progression | breast epithelium | Gene: Rpusd4 (RNA pseudouridylate synthase domain containing 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA modification, RNA splicing, mRNA processing, mRNA pseudouridine synthesis, mitochondrial tRNA pseudouridine synthesis, positive regulation of mitochondrial ... |
Does Knockout of Pole2 in breast epithelium causally result in cell cycle progression? | 0 | 1,470 | Knockout | Pole2 | cell cycle progression | breast epithelium | Gene: Pole2 (polymerase (DNA directed), epsilon 2 (p59 subunit))
Type: protein-coding
Summary: Predicted to enable DNA binding activity. Predicted to be involved in DNA-templated DNA replication and error-prone translesion synthesis. Predicted to be located in nuclear body. Predicted to be part of epsil... |
Does Knockout of Synpo2l in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,683 | Knockout | Synpo2l | protein/peptide distribution | myoblast cell line | Gene: Synpo2l (synaptopodin 2-like)
Type: protein-coding
Summary: Predicted to enable actin binding activity. Involved in several processes, including positive regulation of Rho protein signal transduction; positive regulation of stress fiber assembly; and sarcomere organization. Located in Z disc and n... |
Does Knockout of Lamtor2 in myoblast cell line causally result in protein/peptide distribution? | 1 | 1,684 | Knockout | Lamtor2 | protein/peptide distribution | myoblast cell line | Gene: Lamtor2 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: TORC1 signaling, cellular response to amino acid stimulus, fibroblast migration, intracellular protein localization, positive regulation of MAPK cas... |
Does Knockout of Cbx8 in Colonic Cancer Cell Line causally result in tumorigenicity? | 0 | 2,177 | Knockout | Cbx8 | tumorigenicity | Colonic Cancer Cell Line | Gene: Cbx8 (chromobox 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to hydrogen peroxide, chromatin organization, heterochromatin formation, negative regulation of transcription by RNA polymerase II, positive regulation of DNA repair, positive regul... |
Does Knockout of Inppl1 in Melanoma Cell Line causally result in tumorigenicity? | 0 | 2,187 | Knockout | Inppl1 | tumorigenicity | Melanoma Cell Line | Gene: Inppl1 (inositol polyphosphate phosphatase-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ERK1 and ERK2 cascade, actin filament organization, apoptotic process, cell adhesion, endochondral ossification, endocytosis, establishment of mitotic spindle orientat... |
Does Knockout of Adam10 in Neuroblastoma Cell Line causally result in response to virus? | 0 | 1,422 | Knockout | Adam10 | response to virus | Neuroblastoma Cell Line | Gene: Adam10 (a disintegrin and metallopeptidase domain 10)
Type: protein-coding
Summary: This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. The encoded... |
Does Knockout of Ttk in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,288 | Knockout | Ttk | cell proliferation | Mouse kidney carcinoma cell | Gene: Ttk (Ttk protein kinase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromosome segregation, female meiosis chromosome segregation, meiotic spindle assembly checkpoint signaling, mitotic spindle assembly checkpoint signaling, nuclear chromosome segregation, nucl... |
Does Knockout of Tspan7 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,272 | Knockout | Tspan7 | cell proliferation | Mouse kidney carcinoma cell | Gene: Tspan7 (tetraspanin 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: membrane, plasma membrane, postsynapse
Pathways: Glutamate binding, activation of AMPA receptors and synaptic plasticity, Neuronal System, Neurotransmitter receptors and postsynaptic sig... |
Does Knockout of Dcdc2a in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,683 | Knockout | Dcdc2a | protein/peptide distribution | myoblast cell line | Gene: Dcdc2a (doublecortin domain containing 2a)
Type: protein-coding
Summary: This gene encodes a member of the doublecortin family. The protein encoded by this gene contains two doublecortin domains. The doublecortin domain has been demonstrated to bind tubulin and enhance microtubule polymerization. ... |
Does Knockout of Fignl1 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,275 | Knockout | Fignl1 | cell proliferation | Colonic Cancer Cell Line | Gene: Fignl1 (fidgetin-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ATP metabolic process, cellular response to ionizing radiation, male meiotic nuclear division, microtubule severing, negative regulation of apoptotic process, negative regulation of intrinsic a... |
Does Knockout of Nes in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,259 | Knockout | Nes | cell proliferation | Mouse kidney carcinoma cell | Gene: Nes (nestin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G2/M transition of mitotic cell cycle, brain development, cell projection morphogenesis, embryonic camera-type eye development, negative regulation of neuron apoptotic process, nervous system development, ... |
Does Knockout of Calu in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,280 | Knockout | Calu | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: Calu (calumenin)
Type: protein-coding
Summary: Enables calcium ion binding activity. Located in endoplasmic reticulum. Is expressed in several structures, including central nervous system; genitourinary system; gut; heart; and immune system. Orthologous to human CALU (calumenin). [provided by Alli... |
Does Knockout of Ndp in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,681 | Knockout | Ndp | protein/peptide distribution | myoblast cell line | Gene: Ndp (Norrie disease (pseudoglioma) (human))
Type: protein-coding
Summary: This gene encodes a secreted protein that acts a ligand for multiple different receptors and participates in both Wnt and Wnt-independant signalling. Its activity is important in vascular development of the eye and inner ear... |
Does Knockout of 1700029F12Rik in Microglial Cell Line causally result in protein/peptide accumulation? | 0 | 1,399 | Knockout | 1700029F12Rik | protein/peptide accumulation | Microglial Cell Line | Gene: 1700029F12Rik (RIKEN cDNA 1700029F12 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q810S0, Q9CRB4
Entrez ID: 66479 |
Does Knockout of Cdkl4 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,290 | Knockout | Cdkl4 | cell proliferation | Mouse kidney carcinoma cell | Gene: Cdkl4 (cyclin dependent kinase like 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: ATP binding, cyclin-dependent protein serine/threonine kinase activity, kinase activity, nucleotide binding, protein kinase activity, protein serine kinase activity, protein serin... |
Does Knockout of Msr1 in pro-B-lymphocyte causally result in response to chemicals? | 0 | 1,720 | Knockout | Msr1 | response to chemicals | pro-B-lymphocyte | Gene: Msr1 (macrophage scavenger receptor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: amyloid-beta clearance, cholesterol transport, endocytosis, establishment of localization in cell, lipoprotein transport, negative regulation of gene expression, phagocytosis, eng... |
Does Knockout of Fam174b in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,288 | Knockout | Fam174b | cell proliferation | Mouse kidney carcinoma cell | Gene: Fam174b (family with sequence similarity 174, member B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi organization; CC: Golgi apparatus, membrane, plasma membrane
Pathways:
UniProt: Q8K064
Entrez ID: 100038347 |
Does Knockout of A630095N17Rik in Melanoma Cell Line causally result in cell proliferation? | 0 | 1,838 | Knockout | A630095N17Rik | cell proliferation | Melanoma Cell Line | Gene: A630095N17Rik (RIKEN cDNA A630095N17 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: J3QMK5, J3KMM7, A0A087WQ76
Entrez ID: 381272 |
Does Knockout of Il5ra in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,262 | Knockout | Il5ra | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: Il5ra (interleukin 5 receptor, alpha)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytokine-mediated signaling pathway, eosinophil differentiation, inflammatory response to antigenic stimulus, interleukin-5-mediated signaling pathway, positive regulation of cell ... |
Does Knockout of Rsbn1l in Microglial Cell Line causally result in protein/peptide accumulation? | 0 | 1,399 | Knockout | Rsbn1l | protein/peptide accumulation | Microglial Cell Line | Gene: Rsbn1l (round spermatid basic protein 1-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: dioxygenase activity, metal ion binding, molecular_function, oxidoreductase activity; CC: nucleus
Pathways:
UniProt: A0A0G2JDQ6, D3Z0K6, A0A0G2JEI9
... |
Does Knockout of Txndc8 in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 2,173 | Knockout | Txndc8 | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: Txndc8 (thioredoxin domain containing 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, spermatogenesis; CC: Golgi apparatus, acrosomal vesicle, cytoplasm, sperm flagellum
Pathways:
UniProt: Q69AB2
Entrez ID: 67402 |
Does Knockout of Acer1 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 1,266 | Knockout | Acer1 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: Acer1 (alkaline ceramidase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, cellular response to calcium ion, ceramide catabolic process, ceramide metabolic process, epidermis development, keratinocyte differentiation, lipid metabolic process... |
Does Knockout of Trp53tg5 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 0 | 82 | Knockout | Trp53tg5 | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Trp53tg5 (transformation related protein 53 target 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: chromosome, nucleolus
Pathways:
UniProt: Q9D976
Entrez ID: 73603 |
Does Knockout of Slamf9 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,289 | Knockout | Slamf9 | cell proliferation | Mouse kidney carcinoma cell | Gene: Slamf9 (SLAM family member 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell activation, defense response to bacterium, immune response, plasmacytoid dendritic cell chemotaxis, plasmacytoid dendritic cell differentiation; CC: cell surface, external side of p... |
Does Knockout of Fastk in Breast Adenocarcinoma Cell Line causally result in tumorigenicity? | 0 | 1,664 | Knockout | Fastk | tumorigenicity | Breast Adenocarcinoma Cell Line | Gene: Fastk (Fas-activated serine/threonine kinase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, mitochondrial RNA processing, regulation of RNA splicing, regulation of mitochondrial mRNA stability; MF: ATP binding, Fas-activated serine/threonine kin... |
Does Knockout of Msl1 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,683 | Knockout | Msl1 | protein/peptide distribution | myoblast cell line | Gene: Msl1 (male specific lethal 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, chromatin remodeling, positive regulation of DNA-templated transcription; MF: protein binding, protein-macromolecule adaptor activity; CC: MSL complex, nuclear spec... |
Does Knockout of Slc7a11 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,271 | Knockout | Slc7a11 | cell proliferation | Mouse kidney carcinoma cell | Gene: Slc7a11 (solute carrier family 7 (cationic amino acid transporter, y+ system), member 11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: L-cystine transport, L-glutamate import across plasma membrane, L-glutamate transmembrane transport, L-kynurenine transmembrane ... |
Does Knockout of Ap2s1 in myoblast cell line causally result in protein/peptide distribution? | 1 | 1,684 | Knockout | Ap2s1 | protein/peptide distribution | myoblast cell line | Gene: Ap2s1 (adaptor-related protein complex 2, sigma 1 subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: clathrin-dependent endocytosis, endocytosis, intracellular protein transport, postsynaptic neurotransmitter receptor internalization, protein transport, synapt... |
Does Knockout of Oas1e in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,283 | Knockout | Oas1e | cell proliferation | Mouse kidney carcinoma cell | Gene: Oas1e (2'-5' oligoadenylate synthetase 1E)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: antiviral innate immune response, cellular response to exogenous dsRNA, cellular response to interferon-alpha, cellular response to interferon-beta, defense response to bacter... |
Does Knockout of Smg6 in Microglial Cell Line causally result in response to virus? | 0 | 1,438 | Knockout | Smg6 | response to virus | Microglial Cell Line | Gene: Smg6 (SMG6 nonsense mediated mRNA decay factor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of telomere capping, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, regulation of telomere maintenance; MF: DNA binding, DNA pol... |
Does Knockout of Gsg1 in Microglial Cell Line causally result in cell proliferation? | 0 | 1,359 | Knockout | Gsg1 | cell proliferation | Microglial Cell Line | Gene: Gsg1 (germ cell associated 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: RNA polymerase binding, protein binding; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, plasma membrane
Pathways:
UniProt: Q8R1W2
Entrez ID... |
Does Knockout of Retnlb in pro-B-lymphocyte causally result in response to chemicals? | 0 | 1,720 | Knockout | Retnlb | response to chemicals | pro-B-lymphocyte | Gene: Retnlb (resistin like beta)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: response to bacterium, signal transduction; CC: extracellular region, extracellular space
Pathways:
UniProt: Q99P86
Entrez ID: 57263 |
Does Knockout of Adap2 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,260 | Knockout | Adap2 | cell proliferation | Mouse kidney carcinoma cell | Gene: Adap2 (ArfGAP with dual PH domains 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: heart development; MF: 1-phosphatidylinositol binding, GTPase activator activity, inositol 1,3,4,5 tetrakisphosphate binding, metal ion binding, phosphatidylinositol bisphosphate b... |
Does Knockout of Fam171b in myoblast cell line causally result in protein/peptide distribution? | 1 | 1,679 | Knockout | Fam171b | protein/peptide distribution | myoblast cell line | Gene: Fam171b (family with sequence similarity 171, member B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, membrane, synapse
Pathways:
UniProt: Q14CH0
Entrez ID: 241520 |
Does Knockout of Lrrn4 in Embryonic Stem Cell Line causally result in cell proliferation? | 0 | 578 | Knockout | Lrrn4 | cell proliferation | Embryonic Stem Cell Line | Gene: Lrrn4 (leucine rich repeat neuronal 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: long-term memory, visual learning; CC: membrane, plasma membrane
Pathways:
UniProt: P59383
Entrez ID: 320974 |
Does Knockout of Mis12 in Embryonic Fibroblast Cell Line causally result in cell proliferation? | 1 | 345 | Knockout | Mis12 | cell proliferation | Embryonic Fibroblast Cell Line | Gene: Mis12 (MIS12 kinetochore complex component)
Type: protein-coding
Summary: Predicted to be involved in attachment of mitotic spindle microtubules to kinetochore and kinetochore assembly. Predicted to be located in kinetochore and nucleus. Predicted to be part of MIS12/MIND type complex. Orthologous... |
Does Knockout of Dok6 in Embryonic Cell Line causally result in protein/peptide accumulation? | 0 | 1,440 | Knockout | Dok6 | protein/peptide accumulation | Embryonic Cell Line | Gene: Dok6 (docking protein 6)
Type: protein-coding
Summary: Predicted to be involved in cell surface receptor protein tyrosine kinase signaling pathway. Predicted to be active in cytoplasm. Is expressed in several structures, including central nervous system; dorsal root ganglion; and ureteric tip. Ort... |
Does Knockout of Ghdc in Embryonic Cell Line causally result in protein/peptide accumulation? | 0 | 1,152 | Knockout | Ghdc | protein/peptide accumulation | Embryonic Cell Line | Gene: Ghdc (GH3 domain containing)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cytoplasm, endoplasmic reticulum, nuclear envelope, nucleus
Pathways: Immune System, Innate Immune System, Neutrophil degranulation
UniProt: Q99J23
Entrez ID: 8086... |
Does Knockout of Gm10355 in Microglial Cell Line causally result in response to virus? | 0 | 2,429 | Knockout | Gm10355 | response to virus | Microglial Cell Line | Gene: Gm10355 (predicted gene 10355)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: |
Does Knockout of Cyp4f40 in myoblast cell line causally result in protein/peptide distribution? | 1 | 1,681 | Knockout | Cyp4f40 | protein/peptide distribution | myoblast cell line | Gene: Cyp4f40 (cytochrome P450, family 4, subfamily f, polypeptide 40)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: arachidonate metabolic process, fatty acid metabolic process, leukotriene B4 catabolic process; MF: alkane 1-monooxygenase activity, alpha-tocopherol ome... |
Does Knockout of Zfp729a in Melanoma Cell Line causally result in cell proliferation? | 0 | 2,492 | Knockout | Zfp729a | cell proliferation | Melanoma Cell Line | Gene: Zfp729a (zinc finger protein 729a)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription repressor activity, RNA polymerase II-specific,... |
Does Knockout of Krtap26-1 in Regulatory T cell causally result in protein/peptide accumulation? | 0 | 1,482 | Knockout | Krtap26-1 | protein/peptide accumulation | Regulatory T cell | Gene: Krtap26-1 (keratin associated protein 26-1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: molecular_function, structural molecule activity; CC: cellular_component, cytosol, intermediate filament, keratin filament
Pathways:
UniProt: Q9D7N2
... |
Does Knockout of Exosc4 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,679 | Knockout | Exosc4 | protein/peptide distribution | myoblast cell line | Gene: Exosc4 (exosome component 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA deamination, RNA catabolic process, RNA processing, U4 snRNA 3'-end processing, defense response to virus, gene expression, histone mRNA catabolic process, maturation of 5.8S rRNA, nucl... |
Does Knockout of Nop14 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 1 | 84 | Knockout | Nop14 | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Nop14 (NOP14 nucleolar protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: maturation of SSU-rRNA, rRNA processing, ribosomal small subunit biogenesis, ribosome biogenesis; MF: enzyme binding, snoRNA binding; CC: Noc4p-Nop14p complex, nucleolus, nucleoplasm, nu... |
Does Knockout of Il23r in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,272 | Knockout | Il23r | cell proliferation | Mouse kidney carcinoma cell | Gene: Il23r (interleukin 23 receptor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell surface receptor signaling pathway via JAK-STAT, cytokine-mediated signaling pathway, immune system process, inflammatory response, innate immune response, interleukin-23-mediated s... |
Does Knockout of Rassf4 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,263 | Knockout | Rassf4 | cell proliferation | Colonic Cancer Cell Line | Gene: Rassf4 (Ras association (RalGDS/AF-6) domain family member 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: signal transduction
Pathways: Hippo signaling pathway - multiple species - Mus musculus (mouse)
UniProt: Q8CB96
Entrez ID: 213391 |
Does Knockout of Gtf2h2 in Melanoma Cell Line causally result in cell proliferation? | 1 | 1,270 | Knockout | Gtf2h2 | cell proliferation | Melanoma Cell Line | Gene: Gtf2h2 (general transcription factor II H, polypeptide 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, DNA-templated transcription, nucleotide-excision repair, regulation of transcription by RNA polymerase II, transcription by RNA... |
Does Knockout of Gnb1l in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 1,267 | Knockout | Gnb1l | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: Gnb1l (guanine nucleotide binding protein (G protein), beta polypeptide 1-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage checkpoint signaling, DNA damage response, social behavior; CC: cytoplasm, nucleus
Pathways:
UniProt: Q9EQ15... |
Does Knockout of Kansl1 in Pancreatic Cell Line causally result in protein/peptide accumulation? | 0 | 2,196 | Knockout | Kansl1 | protein/peptide accumulation | Pancreatic Cell Line | Gene: Kansl1 (KAT8 regulatory NSL complex subunit 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, positive regulation of DNA-templated transcription, regulation of mitochondrial transcription; CC: H4 histone acetyltransferase complex, MLL1 compl... |
Does Knockout of Myh14 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,682 | Knockout | Myh14 | protein/peptide distribution | myoblast cell line | Gene: Myh14 (myosin, heavy polypeptide 14)
Type: protein-coding
Summary: Enables several functions, including ATP binding activity; actin filament binding activity; and microfilament motor activity. Acts upstream of or within actin filament-based movement. Located in several cellular components, includi... |
Does Knockout of Irs2 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 1,273 | Knockout | Irs2 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: Irs2 (insulin receptor substrate 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: brain development, cellular response to endothelin, cellular response to glucose stimulus, cellular response to insulin stimulus, epithelial cell migration, insulin receptor signalin... |
Does Knockout of Krtap22-2 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 0 | 1,130 | Knockout | Krtap22-2 | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Krtap22-2 (keratin associated protein 22-2)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: J3QNX6
Entrez ID: 68740 |
Does Knockout of Catsper1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,279 | Knockout | Catsper1 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: Catsper1 (cation channel, sperm associated 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: calcium ion transmembrane transport, calcium ion transport, cell differentiation, flagellated sperm motility, fusion of sperm to egg plasma membrane involved in single fert... |
Does Knockout of Syt14 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,275 | Knockout | Syt14 | cell proliferation | Colonic Cancer Cell Line | Gene: Syt14 (synaptotagmin XIV)
Type: protein-coding
Summary: This gene encodes a member of the synaptotagmin family. The encoded protein may be involved in membrane trafficking. Disruption of a similar gene in human has been associated with autosomal recessive spinocerebellar ataxia. Alternative splici... |
Does Knockout of Ccdc88b in Melanoma Cell Line causally result in cell proliferation? | 0 | 1,838 | Knockout | Ccdc88b | cell proliferation | Melanoma Cell Line | Gene: Ccdc88b (coiled-coil domain containing 88B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic microtubule organization, cytoskeleton-dependent intracellular transport, defense response to protozoan, positive regulation of T cell activation, positive regula... |
Does Knockout of Dhrs13 in Embryonic Cell Line causally result in protein/peptide accumulation? | 0 | 1,152 | Knockout | Dhrs13 | protein/peptide accumulation | Embryonic Cell Line | Gene: Dhrs13 (dehydrogenase/reductase 13)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q5SS80
Entrez ID: 70451 |
Does Knockout of Tgm6 in Embryonic Cell Line causally result in protein/peptide accumulation? | 0 | 1,440 | Knockout | Tgm6 | protein/peptide accumulation | Embryonic Cell Line | Gene: Tgm6 (transglutaminase 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: acyltransferase activity, metal ion binding, protein-glutamine gamma-glutamyltransferase activity, transferase activity; CC: cytoplasm
Pathways:
UniProt: Q14CG3, Q8BM11
... |
Does Knockout of Rhox6 in Mouse cell causally result in protein/peptide accumulation? | 0 | 1,047 | Knockout | Rhox6 | protein/peptide accumulation | Mouse cell | Gene: Rhox6 (reproductive homeobox 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, positive regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator acti... |
Does Knockout of Adal in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,278 | Knockout | Adal | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: Adal (adenosine deaminase-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adenosine catabolic process, inosine biosynthetic process, nucleotide metabolic process, response to alcohol; MF: N6-methyl-AMP deaminase activity, adenosine deaminase activity, deaminas... |
Does Knockout of Ppp6c in Mouse kidney carcinoma cell causally result in cell proliferation? | 1 | 1,290 | Knockout | Ppp6c | cell proliferation | Mouse kidney carcinoma cell | Gene: Ppp6c (protein phosphatase 6, catalytic subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G1/S transition of mitotic cell cycle, cGAS/STING signaling pathway, immune system process, innate immune response, negative regulation of cGAS/STING signaling pathway; ... |
Does Knockout of A3galt2 in Microglial Cell Line causally result in protein/peptide distribution? | 0 | 1,585 | Knockout | A3galt2 | protein/peptide distribution | Microglial Cell Line | Gene: A3galt2 (alpha 1,3-galactosyltransferase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: carbohydrate metabolic process, cellular response to manganese ion, glycosphingolipid biosynthetic process, lipid metabolic process; MF: N-acetyllactosaminide 3-alpha-galacto... |
Does Knockout of Mrps15 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 1 | 82 | Knockout | Mrps15 | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Mrps15 (mitochondrial ribosomal protein S15)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial translation, translation; MF: protein binding, structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial matrix, mitochondrial riboso... |
Does Knockout of Elmod2 in breast epithelium causally result in cell cycle progression? | 0 | 1,469 | Knockout | Elmod2 | cell cycle progression | breast epithelium | Gene: Elmod2 (ELMO/CED-12 domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of defense response to virus; MF: GTPase activator activity
Pathways:
UniProt: Q8BGF6
Entrez ID: 244548 |
Does Knockout of Runx1t1 in Embryonic Fibroblast Cell Line causally result in cell proliferation? | 0 | 345 | Knockout | Runx1t1 | cell proliferation | Embryonic Fibroblast Cell Line | Gene: Runx1t1 (RUNX1 translocation partner 1)
Type: protein-coding
Summary: Enables identical protein binding activity. Involved in negative regulation of fat cell differentiation. Acts upstream of or within fat cell differentiation and regulation of DNA-templated transcription. Located in nucleus. Is e... |
Does Knockout of Fbxo7 in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 1,275 | Knockout | Fbxo7 | cell proliferation | Colonic Cancer Cell Line | Gene: Fbxo7 (F-box protein 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagy of mitochondrion, negative regulation of G1/S transition of mitotic cell cycle, negative regulation of lymphocyte differentiation, negative regulation of neuron apoptotic process, nega... |
Does Knockout of Hspa8 in Mouse kidney carcinoma cell causally result in cell proliferation? | 1 | 1,283 | Knockout | Hspa8 | cell proliferation | Mouse kidney carcinoma cell | Gene: Hspa8 (heat shock protein 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ATP metabolic process, G1/S transition of mitotic cell cycle, RNA splicing, autophagy, axo-dendritic transport, cellular response to cadmium ion, cellular response to heat, cellular respons... |
Does Knockout of Cabp5 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,683 | Knockout | Cabp5 | protein/peptide distribution | myoblast cell line | Gene: Cabp5 (calcium binding protein 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: calcium channel regulator activity, calcium ion binding, metal ion binding; CC: cytoplasm, cytosol
Pathways:
UniProt: Q9JLK3
Entrez ID: 29865 |
Does Knockout of Tmem200a in Melanoma Cell Line causally result in cell proliferation? | 0 | 2,492 | Knockout | Tmem200a | cell proliferation | Melanoma Cell Line | Gene: Tmem200a (transmembrane protein 200A)
Type: protein-coding
Summary: Predicted to be located in membrane. Orthologous to human TMEM200A (transmembrane protein 200A). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: CC: cellular_component, membrane
Pathways:
... |
Does Knockout of Marcksl1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 0 | 81 | Knockout | Marcksl1 | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Marcksl1 (MARCKS-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin filament organization, central nervous system development, positive regulation of cell population proliferation, regulation of presynaptic cytosolic calcium ion concentration; MF: actin b... |
Does Knockout of Toporsl in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 1,565 | Knockout | Toporsl | response to chemicals | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: Toporsl (topoisomerase I binding, arginine/serine-rich like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein monoubiquitination, protein polyubiquitination; MF: transferase activity, ubiquitin protein ligase activity
Pathways:
UniProt: Q9D... |
Does Knockout of Prrc2a in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 1 | 81 | Knockout | Prrc2a | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Prrc2a (proline-rich coiled-coil 2A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cytoplasm, cytosol, nucleoplasm, nucleus, plasma membrane
Pathways:
UniProt: Q7TSC1
Entrez ID: 53761 |
Does Knockout of Slc4a4 in Pancreatic Cell Line causally result in protein/peptide accumulation? | 0 | 2,196 | Knockout | Slc4a4 | protein/peptide accumulation | Pancreatic Cell Line | Gene: Slc4a4 (solute carrier family 4 (anion exchanger), member 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: bicarbonate transport, establishment of localization in cell, inorganic anion transport, monoatomic anion transmembrane transport, monoatomic anion transport... |
Does Knockout of Josd2 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,259 | Knockout | Josd2 | cell proliferation | Mouse kidney carcinoma cell | Gene: Josd2 (Josephin domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein deubiquitination, proteolysis; MF: cysteine-type deubiquitinase activity, deubiquitinase activity, hydrolase activity, peptidase activity; CC: cellular_component, cytoplasm,... |
Does Knockout of Rcc1l in Regulatory T cell causally result in cell proliferation? | 0 | 1,484 | Knockout | Rcc1l | cell proliferation | Regulatory T cell | Gene: Rcc1l (reculator of chromosome condensation 1 like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial fusion, mitochondrial large ribosomal subunit assembly, mitochondrial small ribosomal subunit assembly; MF: guanyl-nucleotide exchange factor activity, ... |
Does Knockout of Nap1l3 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,268 | Knockout | Nap1l3 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: Nap1l3 (nucleosome assembly protein 1-like 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: nucleosome assembly; MF: chromatin binding, histone binding; CC: chromatin, cytoplasm, nucleus
Pathways:
UniProt: Q794H2
Entrez ID: 54561 |
Does Knockout of Lipt2 in Microglial Cell Line causally result in response to virus? | 0 | 1,438 | Knockout | Lipt2 | response to virus | Microglial Cell Line | Gene: Lipt2 (lipoyl(octanoyl) transferase 2 (putative))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of oxygen metabolic process, protein lipoylation; MF: acyltransferase activity, ligase activity, lipoyl(octanoyl) transferase activity, protein bind... |
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