prompt string | hit int64 | screen_id int64 | crispr_strategy string | gene string | phenotype string | cell_type string | gene_context string |
|---|---|---|---|---|---|---|---|
Does Knockout of Tmem253 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,682 | Knockout | Tmem253 | protein/peptide distribution | myoblast cell line | Gene: Tmem253 (transmembrane protein 253)
Type: protein-coding
Summary: Predicted to be located in membrane. Orthologous to human TMEM253 (transmembrane protein 253). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: CC: cellular_component, membrane
Pathways:
... |
Does Knockout of Numb in myoblast cell line causally result in protein/peptide distribution? | 1 | 1,681 | Knockout | Numb | protein/peptide distribution | myoblast cell line | Gene: Numb (NUMB endocytic adaptor protein)
Type: protein-coding
Summary: This gene encodes a conserved protein that is distributed asymmetrically during cell division in the developing embryo. The encoded protein participates in cell fate decisions by interacting with the Notch receptor. Loss of functi... |
Does Knockout of Tbc1d23 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 0 | 84 | Knockout | Tbc1d23 | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Tbc1d23 (TBC1 domain family, member 23)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: animal organ development, brain development, embryonic brain development, nervous system development, neuron projection development, positive regulation of interleukin-6 producti... |
Does Knockout of Nrsn1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 0 | 81 | Knockout | Nrsn1 | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Nrsn1 (neurensin 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: nervous system development; CC: cell projection, cytoplasmic vesicle, growth cone, membrane, neuron projection, neuronal cell body, transport vesicle
Pathways:
UniProt: P97799
... |
Does Knockout of Fign in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,272 | Knockout | Fign | cell proliferation | Mouse kidney carcinoma cell | Gene: Fign (fidgetin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, microtubule severing; MF: ATP binding, ATP hydrolysis activity, microtubule severing ATPase activity, nucleotide binding, protein binding; CC: centrosome, cytoplasm, cytoskeleton, microtu... |
Does Knockout of Rmdn2 in Regulatory T cell causally result in cell proliferation? | 0 | 2,127 | Knockout | Rmdn2 | cell proliferation | Regulatory T cell | Gene: Rmdn2 (regulator of microtubule dynamics 2)
Type: protein-coding
Summary: Predicted to enable microtubule binding activity. Located in mitochondrion. Is expressed in adrenal gland; anal canal; glans of male genital tubercle; hindgut; and testis. Orthologous to human RMDN2 (regulator of microtubule... |
Does Knockout of Cacnb1 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity? | 0 | 2,175 | Knockout | Cacnb1 | tumorigenicity | Breast Adenocarcinoma Cell Line | Gene: Cacnb1 (calcium channel, voltage-dependent, beta 1 subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: calcium ion transmembrane transport, calcium ion transport, cellular response to amyloid-beta, chemical synaptic transmission, monoatomic ion transmembrane tr... |
Does Knockout of Tas2r114 in Regulatory T cell causally result in cell proliferation? | 0 | 1,484 | Knockout | Tas2r114 | cell proliferation | Regulatory T cell | Gene: Tas2r114 (taste receptor, type 2, member 114)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, detection of chemical stimulus involved in sensory perception of bitter taste, detection of chemical stimulus involved in sens... |
Does Knockout of Tonsl in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,286 | Knockout | Tonsl | cell proliferation | Mouse kidney carcinoma cell | Gene: Tonsl (tonsoku-like, DNA repair protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, chromatin organization, double-strand break repair via homologous recombination, protein localization to chromatin, replication fork processing;... |
Does Knockout of Xpo7 in myoblast cell line causally result in protein/peptide distribution? | 1 | 1,683 | Knockout | Xpo7 | protein/peptide distribution | myoblast cell line | Gene: Xpo7 (exportin 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intracellular protein transport, nuclear transport, nucleocytoplasmic transport, protein export from nucleus, protein transport; MF: nuclear export signal receptor activity, protein binding, small GTP... |
Does Knockout of Lbh in breast epithelium causally result in cell cycle progression? | 0 | 1,469 | Knockout | Lbh | cell cycle progression | breast epithelium | Gene: Lbh (limb-bud and heart)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mammary gland development, mammary gland epithelial cell differentiation, negative regulation of DNA-templated transcription, negative regulation of intracellular estrogen receptor signaling pa... |
Does Knockout of Stat4 in breast epithelium causally result in cell cycle progression? | 0 | 1,470 | Knockout | Stat4 | cell cycle progression | breast epithelium | Gene: Stat4 (signal transducer and activator of transcription 4)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases,... |
Does Knockout of Spag1 in breast epithelium causally result in cell cycle progression? | 0 | 1,468 | Knockout | Spag1 | cell cycle progression | breast epithelium | Gene: Spag1 (sperm associated antigen 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: axonemal dynein complex assembly, single fertilization; MF: GTP binding, hydrolase activity, nucleotide binding; CC: cilium, cytoplasm, cytosol, dynein axonemal particle, nucleoplasm,... |
Does Knockout of Defb48 in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,261 | Knockout | Defb48 | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: Defb48 (defensin beta 48)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell chemotaxis, defense response, defense response to bacterium, positive chemotaxis; MF: CCR6 chemokine receptor binding, chemoattractant activity; CC: extracellular region, extracellular sp... |
Does Knockout of Zfp474 in Melanoma Cell Line causally result in protein/peptide accumulation? | 0 | 1,839 | Knockout | Zfp474 | protein/peptide accumulation | Melanoma Cell Line | Gene: Zfp474 (zinc finger protein 474)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: metal ion binding, molecular_function, zinc ion binding
Pathways:
UniProt: Q6V5K9
Entrez ID: 66758 |
Does Knockout of Zfp992 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 1 | 81 | Knockout | Zfp992 | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Zfp992 (zinc finger protein 992)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RN... |
Does Knockout of Tomm22 in breast epithelium causally result in cell cycle progression? | 0 | 1,470 | Knockout | Tomm22 | cell cycle progression | breast epithelium | Gene: Tomm22 (translocase of outer mitochondrial membrane 22)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intracellular protein transport, positive regulation of apoptotic process, protein import into mitochondrial matrix, protein insertion into mitochondrial membrane... |
Does Knockout of Zfp948 in Regulatory T cell causally result in cell proliferation? | 0 | 2,127 | Knockout | Zfp948 | cell proliferation | Regulatory T cell | Gene: Zfp948 (zinc finger protein 948)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of DNA-templated transcription, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: metal ion binding, sequence-specific... |
Does Knockout of Psmg4 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 1 | 82 | Knockout | Psmg4 | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Psmg4 (proteasome (prosome, macropain) assembly chaperone 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, proteasome assembly; MF: molecular_function, protein binding, protein-containing complex binding; CC: cytosol, protein-containing complex... |
Does Knockout of Cct4 in Embryonic Fibroblast Cell Line causally result in cell proliferation? | 1 | 345 | Knockout | Cct4 | cell proliferation | Embryonic Fibroblast Cell Line | Gene: Cct4 (chaperonin containing TCP1 subunit 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: binding of sperm to zona pellucida, positive regulation of telomerase RNA localization to Cajal body, positive regulation of telomere maintenance via telomerase, protein fold... |
Does Knockout of Slc13a3 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 2,307 | Knockout | Slc13a3 | response to chemicals | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: Slc13a3 (solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: alpha-ketoglutarate transport, aspartate transmembrane transport, carboxylic acid transport, citrate transport, dicarboxylic aci... |
Does Knockout of Trim72 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 0 | 82 | Knockout | Trim72 | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Trim72 (tripartite motif-containing 72)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: exocytosis, innate immune response, muscle organ development, muscle system process, negative regulation of insulin receptor signaling pathway, negative regulation of insulin-lik... |
Does Knockout of Rad51ap2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 0 | 81 | Knockout | Rad51ap2 | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Rad51ap2 (RAD51 associated protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: protein-containing complex
Pathways:
UniProt: G3UW63
Entrez ID: 209550 |
Does Knockout of Slc41a1 in macrophage causally result in phagocytosis? | 0 | 1,888 | Knockout | Slc41a1 | phagocytosis | macrophage | Gene: Slc41a1 (solute carrier family 41, member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to magnesium ion, intracellular magnesium ion homeostasis, magnesium ion transmembrane transport, magnesium ion transport, metal ion transport, monoatomic ... |
Does Knockout of Myo7b in renal medulla cell line causally result in response to bacteria? | 0 | 2,049 | Knockout | Myo7b | response to bacteria | renal medulla cell line | Gene: Myo7b (myosin VIIB)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin filament organization, actin filament-based movement, brush border assembly, cell differentiation, endocytosis, sensory organ development, sensory perception of sound; MF: ATP binding, actin b... |
Does Knockout of Arl2 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity? | 1 | 2,172 | Knockout | Arl2 | tumorigenicity | Breast Adenocarcinoma Cell Line | Gene: Arl2 (ADP-ribosylation factor-like 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: acetylcholine transport, bicellular tight junction assembly, centrosome cycle, maintenance of protein location in nucleus, negative regulation of GTPase activity, positive regulati... |
Does Knockout of Cenpm in myoblast cell line causally result in protein/peptide distribution? | 1 | 1,683 | Knockout | Cenpm | protein/peptide distribution | myoblast cell line | Gene: Cenpm (centromere protein M)
Type: protein-coding
Summary: This gene encodes a protein that is present in the nucleus of actively growing cells but is excluded from the nucleus during cell division or during growth arrest as a result of contact inhibition. In human, this protein is a component of ... |
Does Knockout of Mpz in Embryonic Cell Line causally result in protein/peptide accumulation? | 0 | 1,440 | Knockout | Mpz | protein/peptide accumulation | Embryonic Cell Line | Gene: Mpz (myelin protein zero)
Type: protein-coding
Summary: This gene is specifically expressed in Schwann cells of the peripheral nervous system and encodes a type I transmembrane glycoprotein that is a major structural protein of the peripheral myelin sheath. The encoded protein contains a large hyd... |
Does Knockout of Fabp4 in Embryonic Cell Line causally result in protein/peptide accumulation? | 0 | 1,152 | Knockout | Fabp4 | protein/peptide accumulation | Embryonic Cell Line | Gene: Fabp4 (fatty acid binding protein 4, adipocyte)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: brown fat cell differentiation, cellular response to lithium ion, cellular response to tumor necrosis factor, cholesterol homeostasis, fatty acid metabolic process, fatty... |
Does Knockout of Acy1 in Melanoma Cell Line causally result in protein/peptide accumulation? | 0 | 1,839 | Knockout | Acy1 | protein/peptide accumulation | Melanoma Cell Line | Gene: Acy1 (aminoacylase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: amino acid metabolic process, protein catabolic process; MF: aminoacylase activity, hydrolase activity, identical protein binding, metal ion binding; CC: cytoplasm, extracellular exosome
... |
Does Knockout of Pogz in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 1,265 | Knockout | Pogz | cell proliferation | Mammary Gland Tumor Cell Line | Gene: Pogz (pogo transposable element with ZNF domain)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, cell division, double-strand break repair via homologous recombination, kinetochore assembly, mitotic sister chromati... |
Does Knockout of 4930546C10Rik in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,278 | Knockout | 4930546C10Rik | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: 4930546C10Rik (RIKEN cDNA 4930546C10 gene)
Type: ncRNA
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 78931 |
Does Knockout of Pon3 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 1,266 | Knockout | Pon3 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: Pon3 (paraoxonase 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: carboxylic acid catabolic process, coumarin catabolic process, establishment of localization in cell, lactone catabolic process, negative regulation of superoxide anion generation, phenylacetate ca... |
Does Knockout of Hoxb13 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 0 | 1,130 | Knockout | Hoxb13 | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Hoxb13 (homeobox B13)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and methyl-CpG binding activity. Acts upstream of or within epithelial c... |
Does Knockout of Cyyr1 in Embryonic Stem Cell Line causally result in cell proliferation? | 0 | 579 | Knockout | Cyyr1 | cell proliferation | Embryonic Stem Cell Line | Gene: Cyyr1 (cysteine and tyrosine-rich protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, membrane
Pathways:
UniProt: Q8VIH7
Entrez ID: 224405 |
Does Knockout of Chodl in myoblast cell line causally result in protein/peptide distribution? | 1 | 1,681 | Knockout | Chodl | protein/peptide distribution | myoblast cell line | Gene: Chodl (chondrolectin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: nervous system development, positive regulation of axonogenesis, regulation of neuron projection development; MF: carbohydrate binding, hyaluronic acid binding, protein binding; CC: centrosome, cy... |
Does Knockout of Decr2 in Melanoma Cell Line causally result in protein/peptide accumulation? | 0 | 1,839 | Knockout | Decr2 | protein/peptide accumulation | Melanoma Cell Line | Gene: Decr2 (2-4-dienoyl-Coenzyme A reductase 2, peroxisomal)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: fatty acid catabolic process, fatty acid metabolic process, lipid metabolic process, unsaturated fatty acid biosynthetic process; MF: 2,4-dienoyl-CoA reductase (N... |
Does Knockout of Gbp11 in Embryonic Stem Cell Line causally result in cell proliferation? | 0 | 578 | Knockout | Gbp11 | cell proliferation | Embryonic Stem Cell Line | Gene: Gbp11 (guanylate binding protein 11)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q2TA93
Entrez ID: 634650 |
Does Knockout of Robo1 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity? | 0 | 687 | Knockout | Robo1 | tumorigenicity | Immortal Mouse Liver-derived Cell Line | Gene: Robo1 (roundabout guidance receptor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Roundabout signaling pathway, aorta development, aortic valve morphogenesis, axon guidance, axon midline choice point recognition, cell differentiation, cell migration involved in... |
Does Knockout of Clta in Microglial Cell Line causally result in protein/peptide distribution? | 0 | 1,585 | Knockout | Clta | protein/peptide distribution | Microglial Cell Line | Gene: Clta (clathrin light chain A)
Type: protein-coding
Summary: Clathrin is a large, soluble protein composed of heavy and light chains. It functions as the main structural component of the lattice-type cytoplasmic face of coated pits and vesicles which entrap specific macromolecules during receptor-m... |
Does Knockout of Ndufs7 in Embryonic Stem Cell Line causally result in cell proliferation? | 1 | 579 | Knockout | Ndufs7 | cell proliferation | Embryonic Stem Cell Line | Gene: Ndufs7 (NADH:ubiquinone oxidoreductase core subunit S7)
Type: protein-coding
Summary: Predicted to enable NADH dehydrogenase (ubiquinone) activity and protease binding activity. Predicted to contribute to NADH dehydrogenase activity. Predicted to be involved in electron transport coupled proton tr... |
Does Knockout of Mogat1 in Colonic Cancer Cell Line causally result in tumorigenicity? | 0 | 2,178 | Knockout | Mogat1 | tumorigenicity | Colonic Cancer Cell Line | Gene: Mogat1 (monoacylglycerol O-acyltransferase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: diacylglycerol biosynthetic process, glycerol metabolic process, lipid metabolic process, triglyceride biosynthetic process; MF: 2-acylglycerol O-acyltransferase activity, ... |
Does Knockout of Tmem86a in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 1,274 | Knockout | Tmem86a | cell proliferation | Mammary Gland Tumor Cell Line | Gene: Tmem86a (transmembrane protein 86A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: alkenylglycerophosphocholine hydrolase activity, hydrolase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways:
UniProt: Q9D8N3
... |
Does Knockout of Sgo1 in Embryonic Stem Cell Line causally result in cell proliferation? | 1 | 579 | Knockout | Sgo1 | cell proliferation | Embryonic Stem Cell Line | Gene: Sgo1 (shugoshin 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: attachment of spindle microtubules to kinetochore, cell division, centriole-centriole cohesion, chromosome segregation, meiotic chromosome segregation, mitotic sister chromatid cohesion, centromeric;... |
Does Knockout of Tlr4 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,290 | Knockout | Tlr4 | cell proliferation | Mouse kidney carcinoma cell | Gene: Tlr4 (toll-like receptor 4)
Type: protein-coding
Summary: This gene belongs to the evolutionarily-conserved Toll-like receptor family, whose members are type-1 transmembrane proteins that are involved in innate immunity. Toll-like receptors are characterized by an extracellular leucine-rich repeat... |
Does Knockout of Morf4l1 in Lymphoma Cell Line causally result in response to chemicals? | 0 | 1,536 | Knockout | Morf4l1 | response to chemicals | Lymphoma Cell Line | Gene: Morf4l1 (mortality factor 4 like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, cell population proliferation, chromatin organization, chromatin remodeling, double-strand break repair via homologous recombinati... |
Does Knockout of Mup16 in Regulatory T cell causally result in protein/peptide accumulation? | 0 | 1,481 | Knockout | Mup16 | protein/peptide accumulation | Regulatory T cell | Gene: Mup16 (major urinary protein 16)
Type: protein-coding
Summary: Predicted to be located in extracellular space. [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology:
Pathways:
UniProt: P02762
Entrez ID: 100039177 |
Does Knockout of Mptx2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 0 | 82 | Knockout | Mptx2 | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Mptx2 (mucosal pentraxin 2)
Type: protein-coding
Summary: Predicted to enable complement component C1q complex binding activity. Predicted to be involved in innate immune response. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2025]
Gene Ont... |
Does Knockout of Padi6 in Melanoma Cell Line causally result in cell proliferation? | 0 | 1,282 | Knockout | Padi6 | cell proliferation | Melanoma Cell Line | Gene: Padi6 (peptidyl arginine deiminase, type VI)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasm organization, cytoskeleton organization, embryonic cleavage, epigenetic programming in the zygotic pronuclei, in utero embryonic development, intracellular protein... |
Does Knockout of Hccs in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 1 | 81 | Knockout | Hccs | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Hccs (holocytochrome c synthetase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: heme binding, holocytochrome-c synthase activity, lyase activity, metal ion binding, protein binding; CC: cytosol, membrane, mitochondrial inner membrane, mitochondrion
Pathw... |
Does Knockout of Cdh5 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity? | 0 | 688 | Knockout | Cdh5 | tumorigenicity | Immortal Mouse Liver-derived Cell Line | Gene: Cdh5 (cadherin 5)
Type: protein-coding
Summary: This gene encodes a member of the cadherin family of calcium-dependent glycoproteins that mediate cell adhesion and regulate many morphogenetic events during development. The encoded preproprotein is further processed to generate a mature protein. Mi... |
Does Knockout of Lpar3 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,679 | Knockout | Lpar3 | protein/peptide distribution | myoblast cell line | Gene: Lpar3 (lysophosphatidic acid receptor 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, adenylate cyclase-activating G protein-coupled receptor signaling pathway, bleb assembly, gene expression, positive regulation of M... |
Does Knockout of Hacd1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,268 | Knockout | Hacd1 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: Hacd1 (3-hydroxyacyl-CoA dehydratase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cementum mineralization, fatty acid biosynthetic process, fatty acid elongation, fatty acid metabolic process, lipid metabolic process, myotube differentiation, positive regulati... |
Does Knockout of Rgs18 in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,261 | Knockout | Rgs18 | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: Rgs18 (regulator of G-protein signaling 18)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, negative regulation of signal transduction, regulation of G protein-coupled receptor signaling pathway; CC: cytoplasm
P... |
Does Knockout of Vax1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 0 | 167 | Knockout | Vax1 | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Vax1 (ventral anterior homeobox 1)
Type: protein-coding
Summary: This gene encodes a member of the EMX homeobox protein family. The encoded protein functions as a transcription factor which is important in the development of anterior ventral forebrain and visual system. Disruption of this gene cau... |
Does Knockout of Gsc in myoblast cell line causally result in protein/peptide distribution? | 1 | 1,681 | Knockout | Gsc | protein/peptide distribution | myoblast cell line | Gene: Gsc (goosecoid homeobox)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: anatomical structure morphogenesis, animal organ development, dorsal/ventral neural tube patterning, ear development, embryonic skeletal system morphogenesis, forebrain development, middle ear ... |
Does Knockout of Zfp583 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,271 | Knockout | Zfp583 | cell proliferation | Mouse kidney carcinoma cell | Gene: Zfp583 (zinc finger protein 583)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA ... |
Does Knockout of Mzt2 in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,261 | Knockout | Mzt2 | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: Mzt2 (mitotic spindle organizing protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: centrosome, cytoplasm, cytoskeleton, cytosol, gamma-tubulin ring complex, nucleoplasm, spindle
Pathways: Cell Cycle, Cell Cycle, Mitotic, Centrosome maturation, G2/M... |
Does Knockout of Gm15107 in Microglial Cell Line causally result in protein/peptide accumulation? | 0 | 1,398 | Knockout | Gm15107 | protein/peptide accumulation | Microglial Cell Line | Gene: Gm15107 (predicted gene 15107)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: B1B0X0
Entrez ID: 434864 |
Does Knockout of Perp in Microglial Cell Line causally result in protein/peptide distribution? | 0 | 1,585 | Knockout | Perp | protein/peptide distribution | Microglial Cell Line | Gene: Perp (PERP, TP53 apoptosis effector)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Notch signaling pathway, amelogenesis, apoptotic process, cell adhesion, cell-cell adhesion, desmosome organization, heterotypic cell-cell adhesion, intrinsic apoptotic signaling pa... |
Does Knockout of Socs4 in renal medulla cell line causally result in response to bacteria? | 0 | 2,049 | Knockout | Socs4 | response to bacteria | renal medulla cell line | Gene: Socs4 (suppressor of cytokine signaling 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytokine-mediated signaling pathway, intracellular signal transduction, negative regulation of epidermal growth factor-activated receptor activity, negative regulation of sign... |
Does Knockout of Psma3 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 1 | 1,265 | Knockout | Psma3 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: Psma3 (proteasome subunit alpha 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: proteasome-mediated ubiquitin-dependent protein catabolic process, proteolysis involved in protein catabolic process, ubiquitin-dependent protein catabolic process; MF: protein bindin... |
Does Knockout of Hlf in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity? | 0 | 687 | Knockout | Hlf | tumorigenicity | Immortal Mouse Liver-derived Cell Line | Gene: Hlf (hepatic leukemia factor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, rhythmic process, skeletal muscle ce... |
Does Knockout of Apol11a in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,264 | Knockout | Apol11a | cell proliferation | Colonic Cancer Cell Line | Gene: Apol11a (apolipoprotein L 11a)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, chloride transmembrane transport, cytolysis by host of symbiont cells, innate immune response, lipid transport, lipoprotein metabolic process; MF: chloride channel act... |
Does Knockout of Hspg2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 0 | 82 | Knockout | Hspg2 | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Hspg2 (perlecan (heparan sulfate proteoglycan 2))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: angiogenesis, animal organ morphogenesis, brain development, cardiac muscle tissue development, cartilage development involved in endochondral bone morphogenesis, cell ... |
Does Knockout of Tlr5 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,268 | Knockout | Tlr5 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: Tlr5 (toll-like receptor 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: immune response, immune system process, inflammatory response, innate immune response, positive regulation of cytokine production, positive regulation of interleukin-8 production, positive r... |
Does Knockout of Ccdc152 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 0 | 163 | Knockout | Ccdc152 | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Ccdc152 (coiled-coil domain containing 152)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: A0A2I3BPP3, E9PX14
Entrez ID: 100039139 |
Does Knockout of Nsa2 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 1,267 | Knockout | Nsa2 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: Nsa2 (NSA2 ribosome biogenesis homolog)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: maturation of 5.8S rRNA, maturation of LSU-rRNA, rRNA processing, ribosomal large subunit biogenesis, ribosome biogenesis; CC: nucleolus, nucleus, preribosome, preribosome, large... |
Does Knockout of Gpr137b in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,262 | Knockout | Gpr137b | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: Gpr137b (G protein-coupled receptor 137B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagy, negative regulation of bone resorption, negative regulation of osteoclast differentiation, positive regulation of TORC1 signaling, positive regulation of protein loc... |
Does Knockout of Lrrfip1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,262 | Knockout | Lrrfip1 | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: Lrrfip1 (leucine rich repeat (in FLII) interacting protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: ... |
Does Knockout of Sclt1 in Embryonic Cell Line causally result in protein/peptide accumulation? | 0 | 2,403 | Knockout | Sclt1 | protein/peptide accumulation | Embryonic Cell Line | Gene: Sclt1 (sodium channel and clathrin linker 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cilium assembly, clustering of voltage-gated sodium channels; MF: clathrin binding, sodium channel regulator activity; CC: centriole, centrosome, ciliary basal body, ciliary... |
Does Knockout of Ptms in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 1,274 | Knockout | Ptms | cell proliferation | Mammary Gland Tumor Cell Line | Gene: Ptms (parathymosin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: immune system process, negative regulation of apoptotic process, positive regulation of transcription by RNA polymerase II; MF: histone binding, zinc ion binding
Pathways:
UniProt... |
Does Knockout of Dvl1 in macrophage causally result in response to bacteria? | 0 | 2,211 | Knockout | Dvl1 | response to bacteria | macrophage | Gene: Dvl1 (dishevelled segment polarity protein 1)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the Dishevelled family of proteins. These proteins have an N-terminal Dishevelled/Axin domain, a Dishevelled, EGL-10, Plextrin domain, a central PDZ domain, and a C-terminal ... |
Does Knockout of Rbm38 in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,261 | Knockout | Rbm38 | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: Rbm38 (RNA binding motif protein 38)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 3'-UTR-mediated mRNA stabilization, DNA damage response, signal transduction by p53 class mediator, RNA splicing, cell differentiation, mRNA processing, negative regulation of cell ... |
Does Knockout of Shisa7 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,272 | Knockout | Shisa7 | cell proliferation | Mouse kidney carcinoma cell | Gene: Shisa7 (shisa family member 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: gamma-aminobutyric acid receptor clustering, gamma-aminobutyric acid signaling pathway, memory, positive regulation of long-term synaptic potentiation, regulation of AMPA glutamate recept... |
Does Knockout of Zbtb18 in Immortal mouse chromaffin cells causally result in cell viability? | 0 | 2,469 | Knockout | Zbtb18 | cell viability | Immortal mouse chromaffin cells | Gene: Zbtb18 (zinc finger and BTB domain containing 18)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cerebellum development, cerebral cortex development, hippocampus development, homeostasis of number of cells, in utero embryonic development, negative regulation of DNA... |
Does Knockout of Nusap1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals? | 1 | 1,565 | Knockout | Nusap1 | response to chemicals | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: Nusap1 (nucleolar and spindle associated protein 1)
Type: protein-coding
Summary: Enables microtubule binding activity. Predicted to be involved in establishment of mitotic spindle localization; mitotic chromosome condensation; and mitotic cytokinesis. Predicted to act upstream of or within mitoti... |
Does Knockout of Herc3 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity? | 0 | 2,171 | Knockout | Herc3 | tumorigenicity | Breast Adenocarcinoma Cell Line | Gene: Herc3 (hect domain and RLD 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein ubiquitination, ubiquitin-dependent protein catabolic process; MF: transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity; CC: cytoplasm
... |
Does Knockout of Kif13b in renal medulla cell line causally result in response to bacteria? | 0 | 2,049 | Knockout | Kif13b | response to bacteria | renal medulla cell line | Gene: Kif13b (kinesin family member 13B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: establishment of protein localization, microtubule-based movement, regulation of axonogenesis, vesicle transport along microtubule; MF: 14-3-3 protein binding, ATP binding, ATP hydrol... |
Does Knockout of Cel in Microglial Cell Line causally result in protein/peptide distribution? | 0 | 1,585 | Knockout | Cel | protein/peptide distribution | Microglial Cell Line | Gene: Cel (carboxyl ester lipase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ceramide catabolic process, intestinal cholesterol absorption, lipid catabolic process, lipid metabolic process, pancreatic juice secretion, retinol metabolic process; MF: acetylesterase act... |
Does Knockout of Hbb-y in Embryonic Cell Line causally result in protein/peptide accumulation? | 0 | 1,152 | Knockout | Hbb-y | protein/peptide accumulation | Embryonic Cell Line | Gene: Hbb-y (hemoglobin Y, beta-like embryonic chain)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: carbon dioxide transport, erythrocyte development, negative regulation of transcription by RNA polymerase II, oxygen transport; MF: heme binding, hemoglobin alpha binding... |
Does Knockout of Bmx in Breast Adenocarcinoma Cell Line causally result in tumorigenicity? | 0 | 1,664 | Knockout | Bmx | tumorigenicity | Breast Adenocarcinoma Cell Line | Gene: Bmx (BMX non-receptor tyrosine kinase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell receptor signaling pathway, adaptive immune response, apoptotic process, cell adhesion, intracellular signal transduction, signal transduction; MF: ATP binding, kinase acti... |
Does Knockout of Spire1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 0 | 81 | Knockout | Spire1 | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Spire1 (spire type actin nucleation factor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi vesicle transport, actin cytoskeleton organization, actin filament network formation, actin filament organization, actin nucleation, behavioral fear response, cleavag... |
Does Knockout of Gnao1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,267 | Knockout | Gnao1 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: Gnao1 (guanine nucleotide binding protein, alpha O)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled dopamine receptor signaling pathway, G protein-coupled receptor signaling pathway, adenylate cyclase-inhibiting G protein-coupled receptor signaling... |
Does Knockout of Cnksr2 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,260 | Knockout | Cnksr2 | cell proliferation | Mouse kidney carcinoma cell | Gene: Cnksr2 (connector enhancer of kinase suppressor of Ras 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intracellular signal transduction, postsynapse organization, postsynaptic specialization organization, regulation of signal transduction; MF: identical protein ... |
Does Knockout of Lat in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,260 | Knockout | Lat | cell proliferation | Mouse kidney carcinoma cell | Gene: Lat (linker for activation of T cells)
Type: protein-coding
Summary: Predicted to enable molecular condensate scaffold activity; protein kinase binding activity; and signaling receptor complex adaptor activity. Acts upstream of or within gene expression; inflammatory response; and lymphocyte homeo... |
Does Knockout of Ace2 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,685 | Knockout | Ace2 | protein/peptide distribution | myoblast cell line | Gene: Ace2 (angiotensin converting enzyme 2)
Type: protein-coding
Summary: Enables metallocarboxypeptidase activity. Involved in angiotensin maturation; positive regulation of cardiac muscle contraction; and tryptophan transport. Located in brush border membrane and cytoplasm. Is active in extracellular... |
Does Knockout of Adam34 in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,262 | Knockout | Adam34 | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: Adam34 (a disintegrin and metallopeptidase domain 34)
Type: protein-coding
Summary: Predicted to enable metalloendopeptidase activity. Predicted to be involved in male gonad development and proteolysis. Predicted to be active in external side of plasma membrane and sperm head plasma membrane. Is e... |
Does Knockout of Scrn3 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 0 | 1,130 | Knockout | Scrn3 | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Scrn3 (secernin 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: detection of temperature stimulus involved in sensory perception of pain, proteolysis; MF: cysteine-type exopeptidase activity, dipeptidase activity, molecular_function
Pathways:
U... |
Does Knockout of Efr3b in Mouse Embryonic Stem Cell causally result in protein/peptide accumulation? | 0 | 1,077 | Knockout | Efr3b | protein/peptide accumulation | Mouse Embryonic Stem Cell | Gene: Efr3b (EFR3 homolog B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: phosphatidylinositol phosphate biosynthetic process, protein localization to plasma membrane, social behavior, transmission of nerve impulse; CC: actin cytoskeleton, cytoplasm, cytosol, membrane,... |
Does Knockout of Krt20 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,289 | Knockout | Krt20 | cell proliferation | Mouse kidney carcinoma cell | Gene: Krt20 (keratin 20)
Type: protein-coding
Summary: This gene encodes a member of the keratin protein family and is found within a cluster of cytokeratin genes on chromosome 11. Keratins are cytoskeletal proteins that are preferentially expressed in epithelial cells. The encoded protein may help main... |
Does Knockout of Pdyn in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 2,176 | Knockout | Pdyn | cell proliferation | Colonic Cancer Cell Line | Gene: Pdyn (prodynorphin)
Type: protein-coding
Summary: This gene encodes a preproprotein that is proteolytically cleaved to yield a number of active opium-like peptides. These peptides are the endogenous ligands for the Kappa-opioid receptor and similar G-protein-coupled receptors and are thought to fu... |
Does Knockout of Abo in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,683 | Knockout | Abo | protein/peptide distribution | myoblast cell line | Gene: Abo (ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: carbohydrate metabolic process, oligosaccharide biosynthetic process, protein glycosylation; MF: alpha-1,3-galactosyltransferas... |
Does Knockout of L2hgdh in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,679 | Knockout | L2hgdh | protein/peptide distribution | myoblast cell line | Gene: L2hgdh (L-2-hydroxyglutarate dehydrogenase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: small molecule metabolic process; MF: 2-hydroxyglutarate dehydrogenase activity, oxidoreductase activity, oxidoreductase activity, acting on CH-OH group of donors; CC: membra... |
Does Knockout of Mlst8 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,280 | Knockout | Mlst8 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: Mlst8 (MTOR associated protein, LST8 homolog (S. cerevisiae))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, TOR signaling, TORC1 signaling, TORC2 signaling, cellular response to hypoxia, cellular response to nutrient levels, cellular response ... |
Does Knockout of Comtd1 in Mouse kidney carcinoma cell causally result in cell proliferation? | 1 | 1,284 | Knockout | Comtd1 | cell proliferation | Mouse kidney carcinoma cell | Gene: Comtd1 (catechol-O-methyltransferase domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: O-methyltransferase activity, S-adenosylmethionine-dependent methyltransferase activity, methyltransferase activity, transferase activity; CC: membrane, mitocho... |
Does Knockout of Ubr2 in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 2,170 | Knockout | Ubr2 | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: Ubr2 (ubiquitin protein ligase E3 component n-recognin 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell receptor signaling pathway, cellular response to L-leucine, heterochromatin formation, male meiosis I, male meiotic nuclear division, negative regulation... |
Does Knockout of Gcsam in Embryonic Cell Line causally result in protein/peptide accumulation? | 0 | 1,440 | Knockout | Gcsam | protein/peptide accumulation | Embryonic Cell Line | Gene: Gcsam (germinal center associated, signaling and motility)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of lymphocyte migration, regulation of B cell receptor signaling pathway, regulation of lymphocyte migration; MF: actin binding, myosin II ... |
Does Knockout of Sult1c1 in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 1,276 | Knockout | Sult1c1 | cell proliferation | Colonic Cancer Cell Line | Gene: Sult1c1 (sulfotransferase family, cytosolic, 1C, member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 3'-phosphoadenosine 5'-phosphosulfate metabolic process, sulfation, sulfur compound metabolic process, xenobiotic metabolic process; MF: 3'-phosphoadenosine 5'... |
Does Knockout of Chrna5 in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 2,170 | Knockout | Chrna5 | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: Chrna5 (cholinergic receptor, nicotinic, alpha polypeptide 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: acetylcholine receptor signaling pathway, behavioral response to nicotine, cellular response to nicotine, detection of mechanical stimulus involved in senso... |
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