uuid stringlengths 4 8 | template_uuid stringclasses 40 values | question stringlengths 13 193 | answer stringlengths 29 2.2k | benchmark_query stringlengths 138 627 | execution_results stringlengths 2 1.14M | query_type stringclasses 2 values | sql_category stringclasses 26 values | bio_category stringclasses 14 values |
|---|---|---|---|---|---|---|---|---|
Q10.722 | Q10 | Are there any TTC7A SNPs that have a statistically significant association with Parkinson's Disease? | No, according to the largest European genome-wide meta-analysis of Parkinson's Disease (Nalls et al., 2019), there are no SNPs within TTC7A that are significantly associated with Parkinson's Disease. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'TTC7A' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.1247 | Q10 | Are there any SLC8B1 SNPs that have a statistically significant association with Alzheimer's Disease? | No, according to the largest European genome-wide meta-analysis of Alzheimer's Disease (Bellenguez, 2022), there are no SNPs within SLC8B1 that are significantly associated with Alzheimer's Disease. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'SLC8B1' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.1236 | Q10 | Are there any RP11-245J24.1 SNPs that have a statistically significant association with Parkinson's Disease? | No, according to the largest European genome-wide meta-analysis of Parkinson's Disease (Nalls et al., 2019), there are no SNPs within RP11-245J24.1 that are significantly associated with Parkinson's Disease. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'RP11-245J24.1' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.1076 | Q10 | Are there any GPNMB SNPs that have a statistically significant association with Parkinson's Disease? | Yes, according to the largest European genome-wide meta-analysis of Parkinson's Disease (Nalls et al., 2019), there is at least 13 GPNMB SNP that are significantly associatied with Parkinson's Disease:
• rs466225 (GWAS p-value: 4.66e-09; b-value: 0.1037)
• rs858240 (GWAS p-value: 8.48e-09; b-value: -0.1002)
• rs858273 (GWAS p-value: 1.01e-08; b-value: -0.0991)
• rs4282457 (GWAS p-value: 1.02e-08; b-value: 0.1008)
• rs858239 (GWAS p-value: 1.16e-08; b-value: -0.0987)
• rs858274 (GWAS p-value: 1.16e-08; b-value: 0.0987)
• rs199351 (GWAS p-value: 1.41e-08; b-value: -0.0987)
• rs858275 (GWAS p-value: 1.47e-08; b-value: -0.098)
• rs1637190 (GWAS p-value: 1.80e-08; b-value: 0.0974)
• rs199357 (GWAS p-value: 2.48e-08; b-value: 0.097) | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'GPNMB' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_447894', 'Gene': 'GPNMB', 'topRSID': 'rs466225', 'p_GWAS': 4.663443e-09, 'b_GWAS': 0.1037}, {'UUID': 'NDD_SMR_genes_all_update_text_1386055', 'Gene': 'GPNMB', 'topRSID': 'rs858240', 'p_GWAS': 8.480402e-09, 'b_GWAS': -0.1002}, {'UUID': 'NDD_SMR_genes_all_update_text_1461950', 'Gene': 'GPNMB', 'topRSID': 'rs858273', 'p_GWAS': 1.014279e-08, 'b_GWAS': -0.0991}, {'UUID': 'NDD_SMR_genes_all_update_text_1260547', 'Gene': 'GPNMB', 'topRSID': 'rs858273', 'p_GWAS': 1.014279e-08, 'b_GWAS': -0.0991}, {'UUID': 'NDD_SMR_genes_all_update_text_1603160', 'Gene': 'GPNMB', 'topRSID': 'rs858273', 'p_GWAS': 1.014279e-08, 'b_GWAS': -0.0991}, {'UUID': 'NDD_SMR_genes_all_update_text_27340', 'Gene': 'GPNMB', 'topRSID': 'rs4282457', 'p_GWAS': 1.02058e-08, 'b_GWAS': 0.1008}, {'UUID': 'NDD_SMR_genes_all_update_text_1636966', 'Gene': 'GPNMB', 'topRSID': 'rs858274', 'p_GWAS': 1.16205e-08, 'b_GWAS': 0.0987}, {'UUID': 'NDD_SMR_genes_all_update_text_1557764', 'Gene': 'GPNMB', 'topRSID': 'rs858239', 'p_GWAS': 1.16205e-08, 'b_GWAS': -0.0987}, {'UUID': 'NDD_SMR_genes_all_update_text_1279901', 'Gene': 'GPNMB', 'topRSID': 'rs199351', 'p_GWAS': 1.407994e-08, 'b_GWAS': -0.0987}, {'UUID': 'NDD_SMR_genes_all_update_text_1431548', 'Gene': 'GPNMB', 'topRSID': 'rs858275', 'p_GWAS': 1.472477e-08, 'b_GWAS': -0.098}, {'UUID': 'NDD_SMR_genes_all_update_text_20283', 'Gene': 'GPNMB', 'topRSID': 'rs1637190', 'p_GWAS': 1.801492e-08, 'b_GWAS': 0.0974}, {'UUID': 'NDD_SMR_genes_all_update_text_447895', 'Gene': 'GPNMB', 'topRSID': 'rs199357', 'p_GWAS': 2.479388e-08, 'b_GWAS': 0.097}, {'UUID': 'NDD_SMR_genes_all_update_text_447896', 'Gene': 'GPNMB', 'topRSID': 'rs199357', 'p_GWAS': 2.479388e-08, 'b_GWAS': 0.097}, {'UUID': 'NDD_SMR_genes_all_update_text_1167543', 'Gene': 'GPNMB', 'topRSID': 'rs199357', 'p_GWAS': 2.479388e-08, 'b_GWAS': -0.097}, {'UUID': 'NDD_SMR_genes_all_update_text_1237816', 'Gene': 'GPNMB', 'topRSID': 'rs199357', 'p_GWAS': 2.479388e-08, 'b_GWAS': -0.097}, {'UUID': 'NDD_SMR_genes_all_update_text_447897', 'Gene': 'GPNMB', 'topRSID': 'rs199357', 'p_GWAS': 2.479388e-08, 'b_GWAS': 0.097}, {'UUID': 'NDD_SMR_genes_all_update_text_1189327', 'Gene': 'GPNMB', 'topRSID': 'rs199357', 'p_GWAS': 2.479388e-08, 'b_GWAS': -0.097}, {'UUID': 'NDD_SMR_genes_all_update_text_447899', 'Gene': 'GPNMB', 'topRSID': 'rs199357', 'p_GWAS': 2.479388e-08, 'b_GWAS': 0.097}, {'UUID': 'NDD_SMR_genes_all_update_text_1728685', 'Gene': 'GPNMB', 'topRSID': 'rs199357', 'p_GWAS': 2.479388e-08, 'b_GWAS': -0.097}, {'UUID': 'NDD_SMR_genes_all_update_text_1324774', 'Gene': 'GPNMB', 'topRSID': 'rs199357', 'p_GWAS': 2.479388e-08, 'b_GWAS': -0.097}, {'UUID': 'NDD_SMR_genes_all_update_text_1487264', 'Gene': 'GPNMB', 'topRSID': 'rs199357', 'p_GWAS': 2.479388e-08, 'b_GWAS': -0.097}, {'UUID': 'NDD_SMR_genes_all_update_text_447893', 'Gene': 'GPNMB', 'topRSID': 'rs199357', 'p_GWAS': 2.479388e-08, 'b_GWAS': 0.097}, {'UUID': 'NDD_SMR_genes_all_update_text_447900', 'Gene': 'GPNMB', 'topRSID': 'rs199357', 'p_GWAS': 2.479388e-08, 'b_GWAS': 0.097}, {'UUID': 'NDD_SMR_genes_all_update_text_1593746', 'Gene': 'GPNMB', 'topRSID': 'rs199357', 'p_GWAS': 2.479388e-08, 'b_GWAS': -0.097}, {'UUID': 'NDD_SMR_genes_all_update_text_1708096', 'Gene': 'GPNMB', 'topRSID': 'rs199357', 'p_GWAS': 2.479388e-08, 'b_GWAS': -0.097}, {'UUID': 'NDD_SMR_genes_all_update_text_447901', 'Gene': 'GPNMB', 'topRSID': 'rs199355', 'p_GWAS': 2.562562e-08, 'b_GWAS': 0.0969}, {'UUID': 'NDD_SMR_genes_all_update_text_447902', 'Gene': 'GPNMB', 'topRSID': 'rs199355', 'p_GWAS': 2.562562e-08, 'b_GWAS': 0.0969}, {'UUID': 'NDD_SMR_genes_all_update_text_1146423', 'Gene': 'GPNMB', 'topRSID': 'rs199348', 'p_GWAS': 2.562562e-08, 'b_GWAS': 0.0969}, {'UUID': 'NDD_SMR_genes_all_update_text_32845', 'Gene': 'GPNMB', 'topRSID': 'rs1728292', 'p_GWAS': 2.637303e-08, 'b_GWAS': 0.0957}] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.1907 | Q10 | Are there any LINC00595 SNPs that have a statistically significant association with Parkinson's Disease? | No, according to the largest European genome-wide meta-analysis of Parkinson's Disease (Nalls et al., 2019), there are no SNPs within LINC00595 that are significantly associated with Parkinson's Disease. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'LINC00595' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.264 | Q10 | Are there any STX1B SNPs that have a statistically significant association with Parkinson's Disease? | Yes, according to the largest European genome-wide meta-analysis of Parkinson's Disease (Nalls et al., 2019), there are at least 3 STX1B SNPs that are significantly associatied with Parkinson's Disease:
• rs1046276 (GWAS p-value: 2.57e-10; b-value: -0.1176)
• rs13708 (GWAS p-value: 4.25e-09; b-value: -0.1075)
• rs2305880 (GWAS p-value: 3.48e-09; b-value: -0.1081) | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'STX1B' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_974675', 'Gene': 'STX1B', 'topRSID': 'rs1046276', 'p_GWAS': 2.572307e-10, 'b_GWAS': -0.1176}, {'UUID': 'NDD_SMR_genes_all_update_text_1639762', 'Gene': 'STX1B', 'topRSID': 'rs2305880', 'p_GWAS': 3.481743e-09, 'b_GWAS': -0.1081}, {'UUID': 'NDD_SMR_genes_all_update_text_1435343', 'Gene': 'STX1B', 'topRSID': 'rs13708', 'p_GWAS': 4.245904e-09, 'b_GWAS': -0.1075}] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.1437 | Q10 | Are there any RP11-521O16.1 SNPs that have a statistically significant association with Alzheimer's Disease? | Yes, according to the largest European genome-wide meta-analysis of Alzheimer's Disease (Bellenguez, 2022), there are at least 2 RP11-521O16.1 SNPs that are significantly associatied with Alzheimer's Disease:
• rs12617974 (GWAS p-value: 4.92e-09; b-value: -0.0585)
• rs2404175 (GWAS p-value: 5.22e-09; b-value: 0.0584) | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'RP11-521O16.1' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_631113', 'Gene': 'RP11-521O16.1', 'topRSID': 'rs12617974', 'p_GWAS': 4.91573e-09, 'b_GWAS': 0.0585}, {'UUID': 'NDD_SMR_genes_all_update_text_46328', 'Gene': 'RP11-521O16.1', 'topRSID': 'rs12617974', 'p_GWAS': 4.91573e-09, 'b_GWAS': -0.0585}, {'UUID': 'NDD_SMR_genes_all_update_text_631110', 'Gene': 'RP11-521O16.1', 'topRSID': 'rs2404175', 'p_GWAS': 5.220082e-09, 'b_GWAS': 0.0584}, {'UUID': 'NDD_SMR_genes_all_update_text_631112', 'Gene': 'RP11-521O16.1', 'topRSID': 'rs2404175', 'p_GWAS': 5.220082e-09, 'b_GWAS': 0.0584}, {'UUID': 'NDD_SMR_genes_all_update_text_631111', 'Gene': 'RP11-521O16.1', 'topRSID': 'rs2404175', 'p_GWAS': 5.220082e-09, 'b_GWAS': 0.0584}] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.1339 | Q10 | Are there any ACMSD SNPs that have a statistically significant association with Parkinson's Disease? | Yes, according to the largest European genome-wide meta-analysis of Parkinson's Disease (Nalls et al., 2019), there are at least 2 ACMSD SNPs that are significantly associatied with Parkinson's Disease:
• rs4953936 (GWAS p-value: 1.26e-11; b-value: -0.1192)
• rs7599054 (GWAS p-value: 2.67e-12; b-value: -0.1224) | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'ACMSD' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1019157', 'Gene': 'ACMSD', 'topRSID': 'rs7599054', 'p_GWAS': 2.666137e-12, 'b_GWAS': -0.1224}, {'UUID': 'NDD_SMR_genes_all_update_text_1019156', 'Gene': 'ACMSD', 'topRSID': 'rs4953936', 'p_GWAS': 1.263771e-11, 'b_GWAS': -0.1192}] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.243 | Q10 | Are there any C21orf33 SNPs that have a statistically significant association with Alzheimer's Disease? | No, according to the largest European genome-wide meta-analysis of Alzheimer's Disease (Bellenguez, 2022), there are no SNPs within C21orf33 that are significantly associated with Alzheimer's Disease. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'C21orf33' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.1010 | Q10 | Are there any TPRG1 SNPs that have a statistically significant association with Parkinson's Disease? | No, according to the largest European genome-wide meta-analysis of Parkinson's Disease (Nalls et al., 2019), there are no SNPs within TPRG1 that are significantly associated with Parkinson's Disease. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'TPRG1' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.685 | Q10 | Are there any SRGN SNPs that have a statistically significant association with Alzheimer's Disease? | No, according to the largest European genome-wide meta-analysis of Alzheimer's Disease (Bellenguez, 2022), there are no SNPs within SRGN that are significantly associated with Alzheimer's Disease. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'SRGN' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.1268 | Q10 | Are there any CPA2 SNPs that have a statistically significant association with Amyotrophic Lateral Sclerosis? | No, according to genome-wide analysis of Amyotrophic Lateral Sclerosis (Nicolas et al., 2018), there are no SNPs within CPA2 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'CPA2' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.1475 | Q10 | Are there any AC012370.3 SNPs that have a statistically significant association with Parkinson's Disease? | No, according to the largest European genome-wide meta-analysis of Parkinson's Disease (Nalls et al., 2019), there are no SNPs within AC012370.3 that are significantly associated with Parkinson's Disease. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'AC012370.3' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.1502 | Q10 | Are there any LPHN2 SNPs that have a statistically significant association with Alzheimer's Disease? | No, according to the largest European genome-wide meta-analysis of Alzheimer's Disease (Bellenguez, 2022), there are no SNPs within LPHN2 that are significantly associated with Alzheimer's Disease. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'LPHN2' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.370 | Q10 | Are there any NALCN SNPs that have a statistically significant association with Alzheimer's Disease? | No, according to the largest European genome-wide meta-analysis of Alzheimer's Disease (Bellenguez, 2022), there are no SNPs within NALCN that are significantly associated with Alzheimer's Disease. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'NALCN' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.1009 | Q10 | Are there any C7orf55-LUC7L2 SNPs that have a statistically significant association with Alzheimer's Disease? | No, according to the largest European genome-wide meta-analysis of Alzheimer's Disease (Bellenguez, 2022), there are no SNPs within C7orf55-LUC7L2 that are significantly associated with Alzheimer's Disease. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'C7orf55-LUC7L2' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.1239 | Q10 | Are there any SLC3A2 SNPs that have a statistically significant association with Alzheimer's Disease? | No, according to the largest European genome-wide meta-analysis of Alzheimer's Disease (Bellenguez, 2022), there are no SNPs within SLC3A2 that are significantly associated with Alzheimer's Disease. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'SLC3A2' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.595 | Q10 | Are there any MOBKL2B SNPs that have a statistically significant association with Amyotrophic Lateral Sclerosis? | Yes, according to genome-wide analysis of Amyotrophic Lateral Sclerosis (Nicolas et al., 2018), there is at least 1 MOBKL2B SNP that are significantly associatied with Amyotrophic Lateral Sclerosis:
• rs10812605 (GWAS p-value: 4.84e-18; b-value: 0.1212) | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'MOBKL2B' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_745096', 'Gene': 'MOBKL2B', 'topRSID': 'rs10812605', 'p_GWAS': 4.837363e-18, 'b_GWAS': 0.1212}] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.728 | Q10 | Are there any QSOX1 SNPs that have a statistically significant association with Progressive supranuclear palsy? | No, according to genome-wide analysis of Progressive supranuclear palsy (Höglinger et al., 2011), there are no SNPs within QSOX1 that are significantly associated with Progressive supranuclear palsy. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'QSOX1' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.486 | Q10 | Are there any RAB7L1 SNPs that have a statistically significant association with Parkinson's Disease? | Yes, according to the largest European genome-wide meta-analysis of Parkinson's Disease (Nalls et al., 2019), there are at least 2 RAB7L1 SNPs that are significantly associatied with Parkinson's Disease:
• rs823118 (GWAS p-value: 5.15e-09; b-value: 0.0999)
• rs708723 (GWAS p-value: 1.03e-08; b-value: -0.0979) | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'RAB7L1' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1592939', 'Gene': 'RAB7L1', 'topRSID': 'rs823118', 'p_GWAS': 5.154522e-09, 'b_GWAS': 0.0999}, {'UUID': 'NDD_SMR_genes_all_update_text_1634804', 'Gene': 'RAB7L1', 'topRSID': 'rs823118', 'p_GWAS': 5.154522e-09, 'b_GWAS': 0.0999}, {'UUID': 'NDD_SMR_genes_all_update_text_1259430', 'Gene': 'RAB7L1', 'topRSID': 'rs823118', 'p_GWAS': 5.154522e-09, 'b_GWAS': 0.0999}, {'UUID': 'NDD_SMR_genes_all_update_text_1727741', 'Gene': 'RAB7L1', 'topRSID': 'rs823118', 'p_GWAS': 5.154522e-09, 'b_GWAS': 0.0999}, {'UUID': 'NDD_SMR_genes_all_update_text_1461296', 'Gene': 'RAB7L1', 'topRSID': 'rs708723', 'p_GWAS': 1.033447e-08, 'b_GWAS': 0.0979}, {'UUID': 'NDD_SMR_genes_all_update_text_1674701', 'Gene': 'RAB7L1', 'topRSID': 'rs708723', 'p_GWAS': 1.033447e-08, 'b_GWAS': 0.0979}, {'UUID': 'NDD_SMR_genes_all_update_text_1428778', 'Gene': 'RAB7L1', 'topRSID': 'rs708723', 'p_GWAS': 1.033447e-08, 'b_GWAS': -0.0979}, {'UUID': 'NDD_SMR_genes_all_update_text_1706647', 'Gene': 'RAB7L1', 'topRSID': 'rs708723', 'p_GWAS': 1.033447e-08, 'b_GWAS': 0.0979}] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.573 | Q10 | Are there any MBD5 SNPs that have a statistically significant association with Progressive supranuclear palsy? | No, according to genome-wide analysis of Progressive supranuclear palsy (Höglinger et al., 2011), there are no SNPs within MBD5 that are significantly associated with Progressive supranuclear palsy. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'MBD5' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.74 | Q10 | Are there any TUSC2 SNPs that have a statistically significant association with Alzheimer's Disease? | No, according to the largest European genome-wide meta-analysis of Alzheimer's Disease (Bellenguez, 2022), there are no SNPs within TUSC2 that are significantly associated with Alzheimer's Disease. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'TUSC2' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.635 | Q10 | Are there any SORL1 SNPs that have a statistically significant association with Parkinson's Disease? | No, according to the largest European genome-wide meta-analysis of Parkinson's Disease (Nalls et al., 2019), there are no SNPs within SORL1 that are significantly associated with Parkinson's Disease. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'SORL1' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.262 | Q10 | Are there any SPATA7 SNPs that have a statistically significant association with Alzheimer's Disease? | No, according to the largest European genome-wide meta-analysis of Alzheimer's Disease (Bellenguez, 2022), there are no SNPs within SPATA7 that are significantly associated with Alzheimer's Disease. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'SPATA7' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.52 | Q10 | Are there any SPPL2C SNPs that have a statistically significant association with Parkinson's Disease? | Yes, according to the largest European genome-wide meta-analysis of Parkinson's Disease (Nalls et al., 2019), there are at least 5 SPPL2C SNPs that are significantly associatied with Parkinson's Disease:
• rs2532233 (GWAS p-value: 1.47e-19; b-value: 0.2325)
• rs55980621 (GWAS p-value: 3.91e-21; b-value: 0.2538)
• rs56023973 (GWAS p-value: 2.06e-20; b-value: -0.25)
• rs17577369 (GWAS p-value: 3.44e-21; b-value: -0.257)
• rs17573607 (GWAS p-value: 8.00e-21; b-value: -0.2368) | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'SPPL2C' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1242272', 'Gene': 'SPPL2C', 'topRSID': 'rs17577369', 'p_GWAS': 3.436243e-21, 'b_GWAS': -0.257}, {'UUID': 'NDD_SMR_genes_all_update_text_1147254', 'Gene': 'SPPL2C', 'topRSID': 'rs55980621', 'p_GWAS': 3.912023e-21, 'b_GWAS': 0.2538}, {'UUID': 'NDD_SMR_genes_all_update_text_1710348', 'Gene': 'SPPL2C', 'topRSID': 'rs17573607', 'p_GWAS': 7.997568e-21, 'b_GWAS': -0.2368}, {'UUID': 'NDD_SMR_genes_all_update_text_1191170', 'Gene': 'SPPL2C', 'topRSID': 'rs56023973', 'p_GWAS': 2.058553e-20, 'b_GWAS': -0.25}, {'UUID': 'NDD_SMR_genes_all_update_text_19646', 'Gene': 'SPPL2C', 'topRSID': 'rs2532233', 'p_GWAS': 1.473642e-19, 'b_GWAS': 0.2325}] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.201 | Q10 | Are there any NR1H3 SNPs that have a statistically significant association with Amyotrophic Lateral Sclerosis? | No, according to genome-wide analysis of Amyotrophic Lateral Sclerosis (Nicolas et al., 2018), there are no SNPs within NR1H3 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'NR1H3' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.432 | Q10 | Are there any RP13-1032I1.7 SNPs that have a statistically significant association with Progressive supranuclear palsy? | No, according to genome-wide analysis of Progressive supranuclear palsy (Höglinger et al., 2011), there are no SNPs within RP13-1032I1.7 that are significantly associated with Progressive supranuclear palsy. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'RP13-1032I1.7' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.1563 | Q10 | Are there any CTSE SNPs that have a statistically significant association with Progressive supranuclear palsy? | No, according to genome-wide analysis of Progressive supranuclear palsy (Höglinger et al., 2011), there are no SNPs within CTSE that are significantly associated with Progressive supranuclear palsy. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'CTSE' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.336 | Q10 | Are there any PKD1L1 SNPs that have a statistically significant association with Amyotrophic Lateral Sclerosis? | No, according to genome-wide analysis of Amyotrophic Lateral Sclerosis (Nicolas et al., 2018), there are no SNPs within PKD1L1 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'PKD1L1' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.1557 | Q10 | Are there any PCGF2 SNPs that have a statistically significant association with Parkinson's Disease? | No, according to the largest European genome-wide meta-analysis of Parkinson's Disease (Nalls et al., 2019), there are no SNPs within PCGF2 that are significantly associated with Parkinson's Disease. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'PCGF2' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.1539 | Q10 | Are there any CMTM2 SNPs that have a statistically significant association with Progressive supranuclear palsy? | No, according to genome-wide analysis of Progressive supranuclear palsy (Höglinger et al., 2011), there are no SNPs within CMTM2 that are significantly associated with Progressive supranuclear palsy. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'CMTM2' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.426 | Q10 | Are there any EPOR SNPs that have a statistically significant association with Amyotrophic Lateral Sclerosis? | No, according to genome-wide analysis of Amyotrophic Lateral Sclerosis (Nicolas et al., 2018), there are no SNPs within EPOR that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'EPOR' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.637 | Q10 | Are there any MGST1 SNPs that have a statistically significant association with Parkinson's Disease? | No, according to the largest European genome-wide meta-analysis of Parkinson's Disease (Nalls et al., 2019), there are no SNPs within MGST1 that are significantly associated with Parkinson's Disease. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'MGST1' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.941 | Q10 | Are there any GALNT8 SNPs that have a statistically significant association with Amyotrophic Lateral Sclerosis? | No, according to genome-wide analysis of Amyotrophic Lateral Sclerosis (Nicolas et al., 2018), there are no SNPs within GALNT8 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'GALNT8' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.993 | Q10 | Are there any CEP170P1 SNPs that have a statistically significant association with Alzheimer's Disease? | No, according to the largest European genome-wide meta-analysis of Alzheimer's Disease (Bellenguez, 2022), there are no SNPs within CEP170P1 that are significantly associated with Alzheimer's Disease. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'CEP170P1' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.868 | Q10 | Are there any ZNF429 SNPs that have a statistically significant association with Parkinson's Disease? | No, according to the largest European genome-wide meta-analysis of Parkinson's Disease (Nalls et al., 2019), there are no SNPs within ZNF429 that are significantly associated with Parkinson's Disease. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'ZNF429' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.1951 | Q10 | Are there any PABPC1 SNPs that have a statistically significant association with Alzheimer's Disease? | Yes, according to the largest European genome-wide meta-analysis of Alzheimer's Disease (Bellenguez, 2022), there are at least 2 PABPC1 SNPs that are significantly associatied with Alzheimer's Disease:
• rs1693551 (GWAS p-value: 1.46e-08; b-value: 0.0459)
• rs1693560 (GWAS p-value: 3.54e-08; b-value: 0.0452) | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'PABPC1' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1608146', 'Gene': 'PABPC1', 'topRSID': 'rs1693551', 'p_GWAS': 1.456022e-08, 'b_GWAS': -0.0459}, {'UUID': 'NDD_SMR_genes_all_update_text_1393075', 'Gene': 'PABPC1', 'topRSID': 'rs1693551', 'p_GWAS': 1.456022e-08, 'b_GWAS': 0.0459}, {'UUID': 'NDD_SMR_genes_all_update_text_1453596', 'Gene': 'PABPC1', 'topRSID': 'rs1693560', 'p_GWAS': 3.543857e-08, 'b_GWAS': 0.0452}] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.558 | Q10 | Are there any AC069363.1 SNPs that have a statistically significant association with Amyotrophic Lateral Sclerosis? | No, according to genome-wide analysis of Amyotrophic Lateral Sclerosis (Nicolas et al., 2018), there are no SNPs within AC069363.1 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'AC069363.1' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.433 | Q10 | Are there any PPM1H SNPs that have a statistically significant association with Amyotrophic Lateral Sclerosis? | No, according to genome-wide analysis of Amyotrophic Lateral Sclerosis (Nicolas et al., 2018), there are no SNPs within PPM1H that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'PPM1H' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.1777 | Q10 | Are there any MGC57346 SNPs that have a statistically significant association with Alzheimer's Disease? | Yes, according to the largest European genome-wide meta-analysis of Alzheimer's Disease (Bellenguez, 2022), there is at least 1 MGC57346 SNP that are significantly associatied with Alzheimer's Disease:
• rs62056790 (GWAS p-value: 3.01e-08; b-value: -0.0543) | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'MGC57346' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_591168', 'Gene': 'MGC57346', 'topRSID': 'rs62056790', 'p_GWAS': 3.010649e-08, 'b_GWAS': -0.0543}] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.1834 | Q10 | Are there any NSF SNPs that have a statistically significant association with Alzheimer's Disease? | No, according to the largest European genome-wide meta-analysis of Alzheimer's Disease (Bellenguez, 2022), there are no SNPs within NSF that are significantly associated with Alzheimer's Disease. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'NSF' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.1977 | Q10 | Are there any TRAF1 SNPs that have a statistically significant association with Amyotrophic Lateral Sclerosis? | No, according to genome-wide analysis of Amyotrophic Lateral Sclerosis (Nicolas et al., 2018), there are no SNPs within TRAF1 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'TRAF1' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.1506 | Q10 | Are there any PHF20L1 SNPs that have a statistically significant association with Parkinson's Disease? | No, according to the largest European genome-wide meta-analysis of Parkinson's Disease (Nalls et al., 2019), there are no SNPs within PHF20L1 that are significantly associated with Parkinson's Disease. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'PHF20L1' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.1622 | Q10 | Are there any DND1P1 SNPs that have a statistically significant association with Progressive supranuclear palsy? | Yes, according to genome-wide analysis of Progressive supranuclear palsy (Höglinger et al., 2011), there are at least 5 DND1P1 SNPs that are significantly associatied with Progressive supranuclear palsy:
• rs169201 (GWAS p-value: 8.55e-46; b-value: -1.588)
• rs1981997 (GWAS p-value: 1.79e-51; b-value: 1.715)
• rs1635291 (GWAS p-value: 5.42e-51; b-value: -1.421)
• rs12373139 (GWAS p-value: 4.65e-51; b-value: 1.688)
• rs11012 (GWAS p-value: 2.11e-42; b-value: 1.608) | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'DND1P1' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1478184', 'Gene': 'DND1P1', 'topRSID': 'rs1981997', 'p_GWAS': 1.792216e-51, 'b_GWAS': 1.7146}, {'UUID': 'NDD_SMR_genes_all_update_text_1388479', 'Gene': 'DND1P1', 'topRSID': 'rs1981997', 'p_GWAS': 1.792216e-51, 'b_GWAS': 1.7146}, {'UUID': 'NDD_SMR_genes_all_update_text_1604710', 'Gene': 'DND1P1', 'topRSID': 'rs1981997', 'p_GWAS': 1.792216e-51, 'b_GWAS': 1.7146}, {'UUID': 'NDD_SMR_genes_all_update_text_1464414', 'Gene': 'DND1P1', 'topRSID': 'rs1981997', 'p_GWAS': 1.792216e-51, 'b_GWAS': 1.7146}, {'UUID': 'NDD_SMR_genes_all_update_text_1489534', 'Gene': 'DND1P1', 'topRSID': 'rs1981997', 'p_GWAS': 1.792216e-51, 'b_GWAS': 1.7146}, {'UUID': 'NDD_SMR_genes_all_update_text_1596819', 'Gene': 'DND1P1', 'topRSID': 'rs1981997', 'p_GWAS': 1.792216e-51, 'b_GWAS': 1.7146}, {'UUID': 'NDD_SMR_genes_all_update_text_1732391', 'Gene': 'DND1P1', 'topRSID': 'rs1981997', 'p_GWAS': 1.792216e-51, 'b_GWAS': 1.7146}, {'UUID': 'NDD_SMR_genes_all_update_text_1283698', 'Gene': 'DND1P1', 'topRSID': 'rs1981997', 'p_GWAS': 1.792216e-51, 'b_GWAS': 1.7146}, {'UUID': 'NDD_SMR_genes_all_update_text_1452479', 'Gene': 'DND1P1', 'topRSID': 'rs1981997', 'p_GWAS': 1.792216e-51, 'b_GWAS': 1.7146}, {'UUID': 'NDD_SMR_genes_all_update_text_1170870', 'Gene': 'DND1P1', 'topRSID': 'rs1981997', 'p_GWAS': 1.792216e-51, 'b_GWAS': 1.7146}, {'UUID': 'NDD_SMR_genes_all_update_text_1714151', 'Gene': 'DND1P1', 'topRSID': 'rs1981997', 'p_GWAS': 1.792216e-51, 'b_GWAS': 1.7146}, {'UUID': 'NDD_SMR_genes_all_update_text_1264978', 'Gene': 'DND1P1', 'topRSID': 'rs1981997', 'p_GWAS': 1.792216e-51, 'b_GWAS': 1.7146}, {'UUID': 'NDD_SMR_genes_all_update_text_1375925', 'Gene': 'DND1P1', 'topRSID': 'rs12373139', 'p_GWAS': 4.650637e-51, 'b_GWAS': 1.6879}, {'UUID': 'NDD_SMR_genes_all_update_text_1684931', 'Gene': 'DND1P1', 'topRSID': 'rs12373139', 'p_GWAS': 4.650637e-51, 'b_GWAS': 1.6879}, {'UUID': 'NDD_SMR_genes_all_update_text_1336285', 'Gene': 'DND1P1', 'topRSID': 'rs12373139', 'p_GWAS': 4.650637e-51, 'b_GWAS': 1.6879}, {'UUID': 'NDD_SMR_genes_all_update_text_1194212', 'Gene': 'DND1P1', 'topRSID': 'rs1635291', 'p_GWAS': 5.423847e-51, 'b_GWAS': -1.4209}, {'UUID': 'NDD_SMR_genes_all_update_text_1041717', 'Gene': 'DND1P1', 'topRSID': 'rs169201', 'p_GWAS': 8.550985e-46, 'b_GWAS': 1.5881}, {'UUID': 'NDD_SMR_genes_all_update_text_560847', 'Gene': 'DND1P1', 'topRSID': 'rs169201', 'p_GWAS': 8.550985e-46, 'b_GWAS': -1.5881}, {'UUID': 'NDD_SMR_genes_all_update_text_1579417', 'Gene': 'DND1P1', 'topRSID': 'rs11012', 'p_GWAS': 2.1076899999999998e-42, 'b_GWAS': 1.6076}] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.404 | Q10 | Are there any CRHR1 SNPs that have a statistically significant association with Progressive supranuclear palsy? | Yes, according to genome-wide analysis of Progressive supranuclear palsy (Höglinger et al., 2011), there are at least 6 CRHR1 SNPs that are significantly associatied with Progressive supranuclear palsy:
• rs393152 (GWAS p-value: 8.30e-51; b-value: 1.652)
• rs12373139 (GWAS p-value: 4.65e-51; b-value: 1.688)
• rs2074404 (GWAS p-value: 3.33e-37; b-value: 1.044)
• rs169201 (GWAS p-value: 8.55e-46; b-value: 1.588)
• rs173365 (GWAS p-value: 1.21e-15; b-value: 0.4506)
• rs8070723 (GWAS p-value: 2.23e-51; b-value: 1.704) | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'CRHR1' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1336289', 'Gene': 'CRHR1', 'topRSID': 'rs8070723', 'p_GWAS': 2.234221e-51, 'b_GWAS': 1.7039}, {'UUID': 'NDD_SMR_genes_all_update_text_560849', 'Gene': 'CRHR1', 'topRSID': 'rs12373139', 'p_GWAS': 4.6506369999999996e-51, 'b_GWAS': 1.6879}, {'UUID': 'NDD_SMR_genes_all_update_text_1154394', 'Gene': 'CRHR1', 'topRSID': 'rs393152', 'p_GWAS': 8.302968999999999e-51, 'b_GWAS': -1.6521}, {'UUID': 'NDD_SMR_genes_all_update_text_560848', 'Gene': 'CRHR1', 'topRSID': 'rs393152', 'p_GWAS': 8.302968999999999e-51, 'b_GWAS': 1.6521}, {'UUID': 'NDD_SMR_genes_all_update_text_1041721', 'Gene': 'CRHR1', 'topRSID': 'rs169201', 'p_GWAS': 8.550985e-46, 'b_GWAS': 1.5881}, {'UUID': 'NDD_SMR_genes_all_update_text_1041722', 'Gene': 'CRHR1', 'topRSID': 'rs169201', 'p_GWAS': 8.550985e-46, 'b_GWAS': 1.5881}, {'UUID': 'NDD_SMR_genes_all_update_text_1041723', 'Gene': 'CRHR1', 'topRSID': 'rs169201', 'p_GWAS': 8.550985e-46, 'b_GWAS': 1.5881}, {'UUID': 'NDD_SMR_genes_all_update_text_1041725', 'Gene': 'CRHR1', 'topRSID': 'rs169201', 'p_GWAS': 8.550985e-46, 'b_GWAS': 1.5881}, {'UUID': 'NDD_SMR_genes_all_update_text_1041720', 'Gene': 'CRHR1', 'topRSID': 'rs169201', 'p_GWAS': 8.550985e-46, 'b_GWAS': 1.5881}, {'UUID': 'NDD_SMR_genes_all_update_text_1041719', 'Gene': 'CRHR1', 'topRSID': 'rs2074404', 'p_GWAS': 3.331984e-37, 'b_GWAS': 1.0438}, {'UUID': 'NDD_SMR_genes_all_update_text_1041724', 'Gene': 'CRHR1', 'topRSID': 'rs173365', 'p_GWAS': 1.208802e-15, 'b_GWAS': 0.4506}] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.1791 | Q10 | Are there any SPIRE2 SNPs that have a statistically significant association with Amyotrophic Lateral Sclerosis? | No, according to genome-wide analysis of Amyotrophic Lateral Sclerosis (Nicolas et al., 2018), there are no SNPs within SPIRE2 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'SPIRE2' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.195 | Q10 | Are there any PLEKHO2 SNPs that have a statistically significant association with Amyotrophic Lateral Sclerosis? | No, according to genome-wide analysis of Amyotrophic Lateral Sclerosis (Nicolas et al., 2018), there are no SNPs within PLEKHO2 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'PLEKHO2' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.1281 | Q10 | Are there any ZNF668 SNPs that have a statistically significant association with Parkinson's Disease? | No, according to the largest European genome-wide meta-analysis of Parkinson's Disease (Nalls et al., 2019), there are no SNPs within ZNF668 that are significantly associated with Parkinson's Disease. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'ZNF668' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.1381 | Q10 | Are there any CD96 SNPs that have a statistically significant association with Parkinson's Disease? | No, according to the largest European genome-wide meta-analysis of Parkinson's Disease (Nalls et al., 2019), there are no SNPs within CD96 that are significantly associated with Parkinson's Disease. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'CD96' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.677 | Q10 | Are there any DND1P1 SNPs that have a statistically significant association with Parkinson's Disease? | Yes, according to the largest European genome-wide meta-analysis of Parkinson's Disease (Nalls et al., 2019), there are at least 8 DND1P1 SNPs that are significantly associatied with Parkinson's Disease:
• rs1724390 (GWAS p-value: 5.14e-16; b-value: -0.21)
• rs57213017 (GWAS p-value: 2.30e-16; b-value: -0.2117)
• rs199447 (GWAS p-value: 2.80e-19; b-value: -0.2271)
• rs55974014 (GWAS p-value: 8.84e-21; b-value: -0.2571)
• rs1724400 (GWAS p-value: 9.51e-18; b-value: 0.2205)
• rs575074983 (GWAS p-value: 4.98e-12; b-value: -0.2134)
• rs113991678 (GWAS p-value: 2.98e-18; b-value: -0.2239)
• rs4327090 (GWAS p-value: 9.12e-20; b-value: -0.2666) | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'DND1P1' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1730060', 'Gene': 'DND1P1', 'topRSID': 'rs55974014', 'p_GWAS': 8.840428e-21, 'b_GWAS': -0.2571}, {'UUID': 'NDD_SMR_genes_all_update_text_1476423', 'Gene': 'DND1P1', 'topRSID': 'rs55974014', 'p_GWAS': 8.840428e-21, 'b_GWAS': -0.2571}, {'UUID': 'NDD_SMR_genes_all_update_text_1679562', 'Gene': 'DND1P1', 'topRSID': 'rs55974014', 'p_GWAS': 8.840428e-21, 'b_GWAS': -0.2571}, {'UUID': 'NDD_SMR_genes_all_update_text_1386988', 'Gene': 'DND1P1', 'topRSID': 'rs55974014', 'p_GWAS': 8.840428e-21, 'b_GWAS': -0.2571}, {'UUID': 'NDD_SMR_genes_all_update_text_1462890', 'Gene': 'DND1P1', 'topRSID': 'rs55974014', 'p_GWAS': 8.840428e-21, 'b_GWAS': -0.2571}, {'UUID': 'NDD_SMR_genes_all_update_text_1603773', 'Gene': 'DND1P1', 'topRSID': 'rs55974014', 'p_GWAS': 8.840428e-21, 'b_GWAS': -0.2571}, {'UUID': 'NDD_SMR_genes_all_update_text_1488136', 'Gene': 'DND1P1', 'topRSID': 'rs55974014', 'p_GWAS': 8.840428e-21, 'b_GWAS': -0.2571}, {'UUID': 'NDD_SMR_genes_all_update_text_1594920', 'Gene': 'DND1P1', 'topRSID': 'rs55974014', 'p_GWAS': 8.840428e-21, 'b_GWAS': -0.2571}, {'UUID': 'NDD_SMR_genes_all_update_text_1328927', 'Gene': 'DND1P1', 'topRSID': 'rs55974014', 'p_GWAS': 8.840428e-21, 'b_GWAS': -0.2571}, {'UUID': 'NDD_SMR_genes_all_update_text_1281350', 'Gene': 'DND1P1', 'topRSID': 'rs55974014', 'p_GWAS': 8.840428e-21, 'b_GWAS': -0.2571}, {'UUID': 'NDD_SMR_genes_all_update_text_1168832', 'Gene': 'DND1P1', 'topRSID': 'rs55974014', 'p_GWAS': 8.840428e-21, 'b_GWAS': -0.2571}, {'UUID': 'NDD_SMR_genes_all_update_text_1262221', 'Gene': 'DND1P1', 'topRSID': 'rs55974014', 'p_GWAS': 8.840428e-21, 'b_GWAS': -0.2571}, {'UUID': 'NDD_SMR_genes_all_update_text_1451660', 'Gene': 'DND1P1', 'topRSID': 'rs55974014', 'p_GWAS': 8.840428e-21, 'b_GWAS': -0.2571}, {'UUID': 'NDD_SMR_genes_all_update_text_1710345', 'Gene': 'DND1P1', 'topRSID': 'rs55974014', 'p_GWAS': 8.840428e-21, 'b_GWAS': -0.2571}, {'UUID': 'NDD_SMR_genes_all_update_text_1370540', 'Gene': 'DND1P1', 'topRSID': 'rs55974014', 'p_GWAS': 8.840428e-21, 'b_GWAS': -0.2571}, {'UUID': 'NDD_SMR_genes_all_update_text_1640217', 'Gene': 'DND1P1', 'topRSID': 'rs4327090', 'p_GWAS': 9.11874e-20, 'b_GWAS': -0.2666}, {'UUID': 'NDD_SMR_genes_all_update_text_948856', 'Gene': 'DND1P1', 'topRSID': 'rs199447', 'p_GWAS': 2.8006439999999998e-19, 'b_GWAS': -0.2271}, {'UUID': 'NDD_SMR_genes_all_update_text_1564780', 'Gene': 'DND1P1', 'topRSID': 'rs113991678', 'p_GWAS': 2.983957e-18, 'b_GWAS': -0.2239}, {'UUID': 'NDD_SMR_genes_all_update_text_1191167', 'Gene': 'DND1P1', 'topRSID': 'rs1724400', 'p_GWAS': 9.506589e-18, 'b_GWAS': 0.2205}, {'UUID': 'NDD_SMR_genes_all_update_text_491081', 'Gene': 'DND1P1', 'topRSID': 'rs57213017', 'p_GWAS': 2.29774e-16, 'b_GWAS': -0.2117}, {'UUID': 'NDD_SMR_genes_all_update_text_491080', 'Gene': 'DND1P1', 'topRSID': 'rs1724390', 'p_GWAS': 5.141398e-16, 'b_GWAS': -0.21}, {'UUID': 'NDD_SMR_genes_all_update_text_1242266', 'Gene': 'DND1P1', 'topRSID': 'rs575074983', 'p_GWAS': 4.979874e-12, 'b_GWAS': -0.2134}] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.795 | Q10 | Are there any FFAR2 SNPs that have a statistically significant association with Amyotrophic Lateral Sclerosis? | No, according to genome-wide analysis of Amyotrophic Lateral Sclerosis (Nicolas et al., 2018), there are no SNPs within FFAR2 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'FFAR2' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.1463 | Q10 | Are there any FMNL1 SNPs that have a statistically significant association with Parkinson's Disease? | Yes, according to the largest European genome-wide meta-analysis of Parkinson's Disease (Nalls et al., 2019), there are at least 3 FMNL1 SNPs that are significantly associatied with Parkinson's Disease:
• rs12150464 (GWAS p-value: 5.19e-21; b-value: 0.253)
• rs62062283 (GWAS p-value: 5.71e-21; b-value: -0.2377)
• rs62063276 (GWAS p-value: 1.61e-20; b-value: -0.2507) | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'FMNL1' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_19643', 'Gene': 'FMNL1', 'topRSID': 'rs12150464', 'p_GWAS': 5.192914e-21, 'b_GWAS': 0.253}, {'UUID': 'NDD_SMR_genes_all_update_text_1191159', 'Gene': 'FMNL1', 'topRSID': 'rs62062283', 'p_GWAS': 5.707835e-21, 'b_GWAS': -0.2377}, {'UUID': 'NDD_SMR_genes_all_update_text_1435910', 'Gene': 'FMNL1', 'topRSID': 'rs62063276', 'p_GWAS': 1.6142619999999998e-20, 'b_GWAS': -0.2507}, {'UUID': 'NDD_SMR_genes_all_update_text_1710337', 'Gene': 'FMNL1', 'topRSID': 'rs62063276', 'p_GWAS': 1.6142619999999998e-20, 'b_GWAS': -0.2507}] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.1457 | Q10 | Are there any CTC-513N18.7 SNPs that have a statistically significant association with Parkinson's Disease? | No, according to the largest European genome-wide meta-analysis of Parkinson's Disease (Nalls et al., 2019), there are no SNPs within CTC-513N18.7 that are significantly associated with Parkinson's Disease. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'CTC-513N18.7' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.144 | Q10 | Are there any RP11-339B21.10 SNPs that have a statistically significant association with Amyotrophic Lateral Sclerosis? | No, according to genome-wide analysis of Amyotrophic Lateral Sclerosis (Nicolas et al., 2018), there are no SNPs within RP11-339B21.10 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'RP11-339B21.10' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.1188 | Q10 | Are there any MIR4453 SNPs that have a statistically significant association with Progressive supranuclear palsy? | No, according to genome-wide analysis of Progressive supranuclear palsy (Höglinger et al., 2011), there are no SNPs within MIR4453 that are significantly associated with Progressive supranuclear palsy. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'MIR4453' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.3 | Q10 | Are there any HIRIP3 SNPs that have a statistically significant association with Alzheimer's Disease? | Yes, according to the largest European genome-wide meta-analysis of Alzheimer's Disease (Bellenguez, 2022), there are at least 2 HIRIP3 SNPs that are significantly associatied with Alzheimer's Disease:
• rs4077410 (GWAS p-value: 1.26e-08; b-value: 0.0461)
• rs8054556 (GWAS p-value: 2.13e-09; b-value: -0.0491) | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'HIRIP3' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_577414', 'Gene': 'HIRIP3', 'topRSID': 'rs8054556', 'p_GWAS': 2.12692e-09, 'b_GWAS': -0.0491}, {'UUID': 'NDD_SMR_genes_all_update_text_109449', 'Gene': 'HIRIP3', 'topRSID': 'rs4077410', 'p_GWAS': 1.260329e-08, 'b_GWAS': 0.0461}] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.743 | Q10 | Are there any TAFA4 SNPs that have a statistically significant association with Amyotrophic Lateral Sclerosis? | No, according to genome-wide analysis of Amyotrophic Lateral Sclerosis (Nicolas et al., 2018), there are no SNPs within TAFA4 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'TAFA4' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.1871 | Q10 | Are there any RAB3GAP1 SNPs that have a statistically significant association with Parkinson's Disease? | No, according to the largest European genome-wide meta-analysis of Parkinson's Disease (Nalls et al., 2019), there are no SNPs within RAB3GAP1 that are significantly associated with Parkinson's Disease. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'RAB3GAP1' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.1516 | Q10 | Are there any RP11-342K6.4 SNPs that have a statistically significant association with Parkinson's Disease? | No, according to the largest European genome-wide meta-analysis of Parkinson's Disease (Nalls et al., 2019), there are no SNPs within RP11-342K6.4 that are significantly associated with Parkinson's Disease. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'RP11-342K6.4' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.343 | Q10 | Are there any CD55 SNPs that have a statistically significant association with Alzheimer's Disease? | No, according to the largest European genome-wide meta-analysis of Alzheimer's Disease (Bellenguez, 2022), there are no SNPs within CD55 that are significantly associated with Alzheimer's Disease. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'CD55' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.626 | Q10 | Are there any ARL17B SNPs that have a statistically significant association with Parkinson's Disease? | Yes, according to the largest European genome-wide meta-analysis of Parkinson's Disease (Nalls et al., 2019), there are at least 4 ARL17B SNPs that are significantly associatied with Parkinson's Disease:
• rs9896243 (GWAS p-value: 3.17e-18; b-value: -0.2185)
• rs199451 (GWAS p-value: 3.35e-19; b-value: 0.2266)
• rs199533 (GWAS p-value: 1.09e-18; b-value: 0.2224)
• rs538628 (GWAS p-value: 5.93e-19; b-value: 0.225) | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'ARL17B' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_30030', 'Gene': 'ARL17B', 'topRSID': 'rs199451', 'p_GWAS': 3.3508139999999995e-19, 'b_GWAS': 0.2266}, {'UUID': 'NDD_SMR_genes_all_update_text_1147258', 'Gene': 'ARL17B', 'topRSID': 'rs538628', 'p_GWAS': 5.933073e-19, 'b_GWAS': 0.225}, {'UUID': 'NDD_SMR_genes_all_update_text_33016', 'Gene': 'ARL17B', 'topRSID': 'rs199533', 'p_GWAS': 1.090724e-18, 'b_GWAS': 0.2224}, {'UUID': 'NDD_SMR_genes_all_update_text_27184', 'Gene': 'ARL17B', 'topRSID': 'rs9896243', 'p_GWAS': 3.170731e-18, 'b_GWAS': -0.2185}] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.484 | Q10 | Are there any KTN1-AS1 SNPs that have a statistically significant association with Progressive supranuclear palsy? | No, according to genome-wide analysis of Progressive supranuclear palsy (Höglinger et al., 2011), there are no SNPs within KTN1-AS1 that are significantly associated with Progressive supranuclear palsy. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'KTN1-AS1' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.532 | Q10 | Are there any RP11-154D6.1 SNPs that have a statistically significant association with Progressive supranuclear palsy? | No, according to genome-wide analysis of Progressive supranuclear palsy (Höglinger et al., 2011), there are no SNPs within RP11-154D6.1 that are significantly associated with Progressive supranuclear palsy. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'RP11-154D6.1' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.268 | Q10 | Are there any AC010150.1 SNPs that have a statistically significant association with Parkinson's Disease? | No, according to the largest European genome-wide meta-analysis of Parkinson's Disease (Nalls et al., 2019), there are no SNPs within AC010150.1 that are significantly associated with Parkinson's Disease. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'AC010150.1' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.1390 | Q10 | Are there any RP11-175P19.2 SNPs that have a statistically significant association with Alzheimer's Disease? | No, according to the largest European genome-wide meta-analysis of Alzheimer's Disease (Bellenguez, 2022), there are no SNPs within RP11-175P19.2 that are significantly associated with Alzheimer's Disease. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'RP11-175P19.2' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.681 | Q10 | Are there any SKP2 SNPs that have a statistically significant association with Amyotrophic Lateral Sclerosis? | No, according to genome-wide analysis of Amyotrophic Lateral Sclerosis (Nicolas et al., 2018), there are no SNPs within SKP2 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'SKP2' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.492 | Q10 | Are there any ICA1L SNPs that have a statistically significant association with Alzheimer's Disease? | No, according to the largest European genome-wide meta-analysis of Alzheimer's Disease (Bellenguez, 2022), there are no SNPs within ICA1L that are significantly associated with Alzheimer's Disease. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'ICA1L' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.445 | Q10 | Are there any ITGB1BP1 SNPs that have a statistically significant association with Alzheimer's Disease? | No, according to the largest European genome-wide meta-analysis of Alzheimer's Disease (Bellenguez, 2022), there are no SNPs within ITGB1BP1 that are significantly associated with Alzheimer's Disease. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'ITGB1BP1' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.274 | Q10 | Are there any CTC-503J8.6 SNPs that have a statistically significant association with Progressive supranuclear palsy? | No, according to genome-wide analysis of Progressive supranuclear palsy (Höglinger et al., 2011), there are no SNPs within CTC-503J8.6 that are significantly associated with Progressive supranuclear palsy. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'CTC-503J8.6' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.187 | Q10 | Are there any INTS7 SNPs that have a statistically significant association with Progressive supranuclear palsy? | No, according to genome-wide analysis of Progressive supranuclear palsy (Höglinger et al., 2011), there are no SNPs within INTS7 that are significantly associated with Progressive supranuclear palsy. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'INTS7' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.950 | Q10 | Are there any SCARA3 SNPs that have a statistically significant association with Alzheimer's Disease? | Yes, according to the largest European genome-wide meta-analysis of Alzheimer's Disease (Bellenguez, 2022), there are at least 3 SCARA3 SNPs that are significantly associatied with Alzheimer's Disease:
• rs536332 (GWAS p-value: 1.32e-08; b-value: -0.0466)
• rs530324 (GWAS p-value: 5.57e-09; b-value: -0.0478)
• rs9331908 (GWAS p-value: 9.37e-11; b-value: 0.0557) | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'SCARA3' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1199214', 'Gene': 'SCARA3', 'topRSID': 'rs9331908', 'p_GWAS': 9.372289e-11, 'b_GWAS': 0.0557}, {'UUID': 'NDD_SMR_genes_all_update_text_78269', 'Gene': 'SCARA3', 'topRSID': 'rs530324', 'p_GWAS': 5.567094e-09, 'b_GWAS': -0.0478}, {'UUID': 'NDD_SMR_genes_all_update_text_78268', 'Gene': 'SCARA3', 'topRSID': 'rs536332', 'p_GWAS': 1.324089e-08, 'b_GWAS': -0.0466}] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.247 | Q10 | Are there any LRRC37A SNPs that have a statistically significant association with Alzheimer's Disease? | Yes, according to the largest European genome-wide meta-analysis of Alzheimer's Disease (Bellenguez, 2022), there are at least 5 LRRC37A SNPs that are significantly associatied with Alzheimer's Disease:
• rs2696466 (GWAS p-value: 4.51e-10; b-value: 0.053)
• rs62055515 (GWAS p-value: 3.19e-08; b-value: 0.0542)
• rs7225002 (GWAS p-value: 1.63e-10; b-value: -0.0537)
• rs4510068 (GWAS p-value: 1.33e-10; b-value: -0.0546)
• rs2668632 (GWAS p-value: 4.64e-08; b-value: -0.0541) | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'LRRC37A' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1598273', 'Gene': 'LRRC37A', 'topRSID': 'rs4510068', 'p_GWAS': 1.331504e-10, 'b_GWAS': -0.0546}, {'UUID': 'NDD_SMR_genes_all_update_text_1268121', 'Gene': 'LRRC37A', 'topRSID': 'rs4510068', 'p_GWAS': 1.331504e-10, 'b_GWAS': -0.0546}, {'UUID': 'NDD_SMR_genes_all_update_text_1652503', 'Gene': 'LRRC37A', 'topRSID': 'rs4510068', 'p_GWAS': 1.331504e-10, 'b_GWAS': -0.0546}, {'UUID': 'NDD_SMR_genes_all_update_text_1454362', 'Gene': 'LRRC37A', 'topRSID': 'rs4510068', 'p_GWAS': 1.331504e-10, 'b_GWAS': -0.0546}, {'UUID': 'NDD_SMR_genes_all_update_text_1690051', 'Gene': 'LRRC37A', 'topRSID': 'rs4510068', 'p_GWAS': 1.331504e-10, 'b_GWAS': -0.0546}, {'UUID': 'NDD_SMR_genes_all_update_text_1480164', 'Gene': 'LRRC37A', 'topRSID': 'rs4510068', 'p_GWAS': 1.331504e-10, 'b_GWAS': -0.0546}, {'UUID': 'NDD_SMR_genes_all_update_text_1247089', 'Gene': 'LRRC37A', 'topRSID': 'rs4510068', 'p_GWAS': 1.331504e-10, 'b_GWAS': -0.0546}, {'UUID': 'NDD_SMR_genes_all_update_text_1378573', 'Gene': 'LRRC37A', 'topRSID': 'rs4510068', 'p_GWAS': 1.331504e-10, 'b_GWAS': -0.0546}, {'UUID': 'NDD_SMR_genes_all_update_text_1174603', 'Gene': 'LRRC37A', 'topRSID': 'rs4510068', 'p_GWAS': 1.331504e-10, 'b_GWAS': -0.0546}, {'UUID': 'NDD_SMR_genes_all_update_text_1717383', 'Gene': 'LRRC37A', 'topRSID': 'rs4510068', 'p_GWAS': 1.331504e-10, 'b_GWAS': -0.0546}, {'UUID': 'NDD_SMR_genes_all_update_text_1291766', 'Gene': 'LRRC37A', 'topRSID': 'rs7225002', 'p_GWAS': 1.628144e-10, 'b_GWAS': -0.0537}, {'UUID': 'NDD_SMR_genes_all_update_text_1584316', 'Gene': 'LRRC37A', 'topRSID': 'rs7225002', 'p_GWAS': 1.628144e-10, 'b_GWAS': -0.0537}, {'UUID': 'NDD_SMR_genes_all_update_text_1157205', 'Gene': 'LRRC37A', 'topRSID': 'rs7225002', 'p_GWAS': 1.628144e-10, 'b_GWAS': -0.0537}, {'UUID': 'NDD_SMR_genes_all_update_text_1343159', 'Gene': 'LRRC37A', 'topRSID': 'rs7225002', 'p_GWAS': 1.628144e-10, 'b_GWAS': -0.0537}, {'UUID': 'NDD_SMR_genes_all_update_text_1466650', 'Gene': 'LRRC37A', 'topRSID': 'rs7225002', 'p_GWAS': 1.628144e-10, 'b_GWAS': -0.0537}, {'UUID': 'NDD_SMR_genes_all_update_text_1106831', 'Gene': 'LRRC37A', 'topRSID': 'rs2696466', 'p_GWAS': 4.509301e-10, 'b_GWAS': 0.053}, {'UUID': 'NDD_SMR_genes_all_update_text_2658', 'Gene': 'LRRC37A', 'topRSID': 'rs2696466', 'p_GWAS': 4.509301e-10, 'b_GWAS': 0.053}, {'UUID': 'NDD_SMR_genes_all_update_text_24566', 'Gene': 'LRRC37A', 'topRSID': 'rs2696466', 'p_GWAS': 4.509301e-10, 'b_GWAS': -0.053}, {'UUID': 'NDD_SMR_genes_all_update_text_30833', 'Gene': 'LRRC37A', 'topRSID': 'rs2696466', 'p_GWAS': 4.509301e-10, 'b_GWAS': -0.053}, {'UUID': 'NDD_SMR_genes_all_update_text_28414', 'Gene': 'LRRC37A', 'topRSID': 'rs62055515', 'p_GWAS': 3.19115e-08, 'b_GWAS': 0.0542}, {'UUID': 'NDD_SMR_genes_all_update_text_1203016', 'Gene': 'LRRC37A', 'topRSID': 'rs2668632', 'p_GWAS': 4.638303e-08, 'b_GWAS': -0.0541}] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.1100 | Q10 | Are there any FAM96A SNPs that have a statistically significant association with Alzheimer's Disease? | No, according to the largest European genome-wide meta-analysis of Alzheimer's Disease (Bellenguez, 2022), there are no SNPs within FAM96A that are significantly associated with Alzheimer's Disease. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'FAM96A' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.1018 | Q10 | Are there any ZNF771 SNPs that have a statistically significant association with Parkinson's Disease? | No, according to the largest European genome-wide meta-analysis of Parkinson's Disease (Nalls et al., 2019), there are no SNPs within ZNF771 that are significantly associated with Parkinson's Disease. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'ZNF771' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.590 | Q10 | Are there any MMRN1 SNPs that have a statistically significant association with Parkinson's Disease? | Yes, according to the largest European genome-wide meta-analysis of Parkinson's Disease (Nalls et al., 2019), there is at least 12 MMRN1 SNP that are significantly associatied with Parkinson's Disease:
• rs28532850 (GWAS p-value: 1.13e-14; b-value: 0.3383)
• rs1866995 (GWAS p-value: 7.81e-14; b-value: 0.3236)
• rs79093919 (GWAS p-value: 1.63e-12; b-value: 0.3143)
• rs112334424 (GWAS p-value: 1.97e-12; b-value: -0.3103)
• rs78945589 (GWAS p-value: 2.36e-12; b-value: 0.312)
• rs75329999 (GWAS p-value: 3.52e-12; b-value: -0.3095)
• rs76644078 (GWAS p-value: 4.20e-12; b-value: 0.3084)
• rs79994234 (GWAS p-value: 5.18e-12; b-value: 0.3057)
• rs75943295 (GWAS p-value: 5.30e-10; b-value: 0.2782)
• rs142595770 (GWAS p-value: 6.76e-10; b-value: 0.2518) | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'MMRN1' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1366625', 'Gene': 'MMRN1', 'topRSID': 'rs28532850', 'p_GWAS': 1.129613e-14, 'b_GWAS': 0.3383}, {'UUID': 'NDD_SMR_genes_all_update_text_1475008', 'Gene': 'MMRN1', 'topRSID': 'rs1866995', 'p_GWAS': 7.812441e-14, 'b_GWAS': 0.3236}, {'UUID': 'NDD_SMR_genes_all_update_text_1236436', 'Gene': 'MMRN1', 'topRSID': 'rs79093919', 'p_GWAS': 1.63038e-12, 'b_GWAS': 0.3143}, {'UUID': 'NDD_SMR_genes_all_update_text_1430395', 'Gene': 'MMRN1', 'topRSID': 'rs79093919', 'p_GWAS': 1.63038e-12, 'b_GWAS': 0.3143}, {'UUID': 'NDD_SMR_genes_all_update_text_1140477', 'Gene': 'MMRN1', 'topRSID': 'rs112334424', 'p_GWAS': 1.974383e-12, 'b_GWAS': -0.3103}, {'UUID': 'NDD_SMR_genes_all_update_text_998615', 'Gene': 'MMRN1', 'topRSID': 'rs78945589', 'p_GWAS': 2.36222e-12, 'b_GWAS': 0.312}, {'UUID': 'NDD_SMR_genes_all_update_text_19153', 'Gene': 'MMRN1', 'topRSID': 'rs75329999', 'p_GWAS': 3.524216e-12, 'b_GWAS': -0.3095}, {'UUID': 'NDD_SMR_genes_all_update_text_1323565', 'Gene': 'MMRN1', 'topRSID': 'rs76644078', 'p_GWAS': 4.19839e-12, 'b_GWAS': 0.3084}, {'UUID': 'NDD_SMR_genes_all_update_text_1385772', 'Gene': 'MMRN1', 'topRSID': 'rs79994234', 'p_GWAS': 5.175522e-12, 'b_GWAS': 0.3057}, {'UUID': 'NDD_SMR_genes_all_update_text_1486995', 'Gene': 'MMRN1', 'topRSID': 'rs75943295', 'p_GWAS': 5.304484e-10, 'b_GWAS': 0.2782}, {'UUID': 'NDD_SMR_genes_all_update_text_1167152', 'Gene': 'MMRN1', 'topRSID': 'rs75943295', 'p_GWAS': 5.304484e-10, 'b_GWAS': 0.2782}, {'UUID': 'NDD_SMR_genes_all_update_text_1728267', 'Gene': 'MMRN1', 'topRSID': 'rs75943295', 'p_GWAS': 5.304484e-10, 'b_GWAS': 0.2782}, {'UUID': 'NDD_SMR_genes_all_update_text_1279470', 'Gene': 'MMRN1', 'topRSID': 'rs75943295', 'p_GWAS': 5.304484e-10, 'b_GWAS': 0.2782}, {'UUID': 'NDD_SMR_genes_all_update_text_1260051', 'Gene': 'MMRN1', 'topRSID': 'rs75943295', 'p_GWAS': 5.304484e-10, 'b_GWAS': 0.2782}, {'UUID': 'NDD_SMR_genes_all_update_text_1450943', 'Gene': 'MMRN1', 'topRSID': 'rs75943295', 'p_GWAS': 5.304484e-10, 'b_GWAS': 0.2782}, {'UUID': 'NDD_SMR_genes_all_update_text_1461650', 'Gene': 'MMRN1', 'topRSID': 'rs142595770', 'p_GWAS': 6.761577e-10, 'b_GWAS': 0.2518}, {'UUID': 'NDD_SMR_genes_all_update_text_1188798', 'Gene': 'MMRN1', 'topRSID': 'rs116370523', 'p_GWAS': 2.788864e-09, 'b_GWAS': 0.2633}, {'UUID': 'NDD_SMR_genes_all_update_text_1602983', 'Gene': 'MMRN1', 'topRSID': 'rs116370523', 'p_GWAS': 2.788864e-09, 'b_GWAS': 0.2633}, {'UUID': 'NDD_SMR_genes_all_update_text_1593387', 'Gene': 'MMRN1', 'topRSID': 'rs116370523', 'p_GWAS': 2.788864e-09, 'b_GWAS': 0.2633}, {'UUID': 'NDD_SMR_genes_all_update_text_1707457', 'Gene': 'MMRN1', 'topRSID': 'rs116370523', 'p_GWAS': 2.788864e-09, 'b_GWAS': 0.2633}, {'UUID': 'NDD_SMR_genes_all_update_text_1636024', 'Gene': 'MMRN1', 'topRSID': 'rs77823616', 'p_GWAS': 4.627665e-08, 'b_GWAS': 0.2033}] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.1629 | Q10 | Are there any PTPRR SNPs that have a statistically significant association with Parkinson's Disease? | No, according to the largest European genome-wide meta-analysis of Parkinson's Disease (Nalls et al., 2019), there are no SNPs within PTPRR that are significantly associated with Parkinson's Disease. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'PTPRR' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.535 | Q10 | Are there any RP13-638C3.3 SNPs that have a statistically significant association with Parkinson's Disease? | No, according to the largest European genome-wide meta-analysis of Parkinson's Disease (Nalls et al., 2019), there are no SNPs within RP13-638C3.3 that are significantly associated with Parkinson's Disease. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'RP13-638C3.3' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.899 | Q10 | Are there any ANGPTL7 SNPs that have a statistically significant association with Parkinson's Disease? | No, according to the largest European genome-wide meta-analysis of Parkinson's Disease (Nalls et al., 2019), there are no SNPs within ANGPTL7 that are significantly associated with Parkinson's Disease. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'ANGPTL7' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.1483 | Q10 | Are there any SERPINA10 SNPs that have a statistically significant association with Alzheimer's Disease? | No, according to the largest European genome-wide meta-analysis of Alzheimer's Disease (Bellenguez, 2022), there are no SNPs within SERPINA10 that are significantly associated with Alzheimer's Disease. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'SERPINA10' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.1109 | Q10 | Are there any KANSL1 SNPs that have a statistically significant association with Parkinson's Disease? | Yes, according to the largest European genome-wide meta-analysis of Parkinson's Disease (Nalls et al., 2019), there are at least 24 KANSL1 SNPs that are significantly associatied with Parkinson's Disease:
• rs8712 (GWAS p-value: 3.71e-21; b-value: -0.2379)
• rs17661015 (GWAS p-value: 4.30e-21; b-value: -0.2573)
• rs1966345 (GWAS p-value: 4.63e-21; b-value: -0.2392)
• rs2316955 (GWAS p-value: 5.71e-21; b-value: -0.2377)
• rs41374248 (GWAS p-value: 5.93e-21; b-value: -0.2376)
• rs62060852 (GWAS p-value: 5.93e-21; b-value: -0.2376)
• rs12150087 (GWAS p-value: 6.10e-21; b-value: -0.2394)
• rs112197756 (GWAS p-value: 6.15e-21; b-value: -0.2375)
• rs111273167 (GWAS p-value: 8.32e-21; b-value: -0.2526)
• rs62057144 (GWAS p-value: 1.79e-20; b-value: -0.2504) | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'KANSL1' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_491134', 'Gene': 'KANSL1', 'topRSID': 'rs8712', 'p_GWAS': 3.710891e-21, 'b_GWAS': -0.2379}, {'UUID': 'NDD_SMR_genes_all_update_text_491138', 'Gene': 'KANSL1', 'topRSID': 'rs17661015', 'p_GWAS': 4.30481e-21, 'b_GWAS': -0.2573}, {'UUID': 'NDD_SMR_genes_all_update_text_491141', 'Gene': 'KANSL1', 'topRSID': 'rs1966345', 'p_GWAS': 4.627357e-21, 'b_GWAS': -0.2392}, {'UUID': 'NDD_SMR_genes_all_update_text_491144', 'Gene': 'KANSL1', 'topRSID': 'rs1966345', 'p_GWAS': 4.627357e-21, 'b_GWAS': -0.2392}, {'UUID': 'NDD_SMR_genes_all_update_text_491143', 'Gene': 'KANSL1', 'topRSID': 'rs1966345', 'p_GWAS': 4.627357e-21, 'b_GWAS': -0.2392}, {'UUID': 'NDD_SMR_genes_all_update_text_491142', 'Gene': 'KANSL1', 'topRSID': 'rs1966345', 'p_GWAS': 4.627357e-21, 'b_GWAS': -0.2392}, {'UUID': 'NDD_SMR_genes_all_update_text_491147', 'Gene': 'KANSL1', 'topRSID': 'rs2316955', 'p_GWAS': 5.707835e-21, 'b_GWAS': -0.2377}, {'UUID': 'NDD_SMR_genes_all_update_text_491135', 'Gene': 'KANSL1', 'topRSID': 'rs41374248', 'p_GWAS': 5.926176e-21, 'b_GWAS': -0.2376}, {'UUID': 'NDD_SMR_genes_all_update_text_491136', 'Gene': 'KANSL1', 'topRSID': 'rs62060852', 'p_GWAS': 5.926176e-21, 'b_GWAS': -0.2376}, {'UUID': 'NDD_SMR_genes_all_update_text_491140', 'Gene': 'KANSL1', 'topRSID': 'rs12150087', 'p_GWAS': 6.101391e-21, 'b_GWAS': -0.2394}, {'UUID': 'NDD_SMR_genes_all_update_text_491139', 'Gene': 'KANSL1', 'topRSID': 'rs12150087', 'p_GWAS': 6.101391e-21, 'b_GWAS': -0.2394}, {'UUID': 'NDD_SMR_genes_all_update_text_948902', 'Gene': 'KANSL1', 'topRSID': 'rs112197756', 'p_GWAS': 6.152774e-21, 'b_GWAS': -0.2375}, {'UUID': 'NDD_SMR_genes_all_update_text_948914', 'Gene': 'KANSL1', 'topRSID': 'rs111273167', 'p_GWAS': 8.316151e-21, 'b_GWAS': -0.2526}, {'UUID': 'NDD_SMR_genes_all_update_text_948910', 'Gene': 'KANSL1', 'topRSID': 'rs62057144', 'p_GWAS': 1.791684e-20, 'b_GWAS': -0.2504}, {'UUID': 'NDD_SMR_genes_all_update_text_948901', 'Gene': 'KANSL1', 'topRSID': 'rs199529', 'p_GWAS': 5.749695e-20, 'b_GWAS': -0.215}, {'UUID': 'NDD_SMR_genes_all_update_text_33014', 'Gene': 'KANSL1', 'topRSID': 'rs79730878', 'p_GWAS': 6.812257e-20, 'b_GWAS': -0.2447}, {'UUID': 'NDD_SMR_genes_all_update_text_491151', 'Gene': 'KANSL1', 'topRSID': 'rs2668665', 'p_GWAS': 1.0312529999999999e-19, 'b_GWAS': -0.2335}, {'UUID': 'NDD_SMR_genes_all_update_text_491145', 'Gene': 'KANSL1', 'topRSID': 'rs2696610', 'p_GWAS': 1.068802e-19, 'b_GWAS': -0.2334}, {'UUID': 'NDD_SMR_genes_all_update_text_491152', 'Gene': 'KANSL1', 'topRSID': 'rs571792649', 'p_GWAS': 1.3241959999999998e-19, 'b_GWAS': -0.2328}, {'UUID': 'NDD_SMR_genes_all_update_text_948906', 'Gene': 'KANSL1', 'topRSID': 'rs2532233', 'p_GWAS': 1.473642e-19, 'b_GWAS': -0.2325}, {'UUID': 'NDD_SMR_genes_all_update_text_948907', 'Gene': 'KANSL1', 'topRSID': 'rs2532233', 'p_GWAS': 1.473642e-19, 'b_GWAS': -0.2325}, {'UUID': 'NDD_SMR_genes_all_update_text_1640221', 'Gene': 'KANSL1', 'topRSID': 'rs2532233', 'p_GWAS': 1.473642e-19, 'b_GWAS': -0.2325}, {'UUID': 'NDD_SMR_genes_all_update_text_491148', 'Gene': 'KANSL1', 'topRSID': 'rs545648705', 'p_GWAS': 1.5270689999999999e-19, 'b_GWAS': -0.2324}, {'UUID': 'NDD_SMR_genes_all_update_text_491149', 'Gene': 'KANSL1', 'topRSID': 'rs546433642', 'p_GWAS': 2.4229079999999996e-19, 'b_GWAS': -0.2311}, {'UUID': 'NDD_SMR_genes_all_update_text_1435917', 'Gene': 'KANSL1', 'topRSID': 'rs199447', 'p_GWAS': 2.8006439999999998e-19, 'b_GWAS': -0.2271}, {'UUID': 'NDD_SMR_genes_all_update_text_30028', 'Gene': 'KANSL1', 'topRSID': 'rs199451', 'p_GWAS': 3.3508139999999995e-19, 'b_GWAS': 0.2266}, {'UUID': 'NDD_SMR_genes_all_update_text_1147256', 'Gene': 'KANSL1', 'topRSID': 'rs169201', 'p_GWAS': 4.460973e-19, 'b_GWAS': 0.2258}, {'UUID': 'NDD_SMR_genes_all_update_text_19647', 'Gene': 'KANSL1', 'topRSID': 'rs112995313', 'p_GWAS': 1.891693e-18, 'b_GWAS': 0.2261}, {'UUID': 'NDD_SMR_genes_all_update_text_948903', 'Gene': 'KANSL1', 'topRSID': 'rs199525', 'p_GWAS': 3.699924e-16, 'b_GWAS': -0.2037}, {'UUID': 'NDD_SMR_genes_all_update_text_1242276', 'Gene': 'KANSL1', 'topRSID': 'rs2732615', 'p_GWAS': 6.139616e-11, 'b_GWAS': -0.2191}] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.421 | Q10 | Are there any APOL6 SNPs that have a statistically significant association with Progressive supranuclear palsy? | No, according to genome-wide analysis of Progressive supranuclear palsy (Höglinger et al., 2011), there are no SNPs within APOL6 that are significantly associated with Progressive supranuclear palsy. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'APOL6' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.277 | Q10 | Are there any COLGALT1 SNPs that have a statistically significant association with Progressive supranuclear palsy? | No, according to genome-wide analysis of Progressive supranuclear palsy (Höglinger et al., 2011), there are no SNPs within COLGALT1 that are significantly associated with Progressive supranuclear palsy. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'COLGALT1' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.1174 | Q10 | Are there any RP11-9G1.3 SNPs that have a statistically significant association with Amyotrophic Lateral Sclerosis? | No, according to genome-wide analysis of Amyotrophic Lateral Sclerosis (Nicolas et al., 2018), there are no SNPs within RP11-9G1.3 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'RP11-9G1.3' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.1487 | Q10 | Are there any LACTB SNPs that have a statistically significant association with Alzheimer's Disease? | Yes, according to the largest European genome-wide meta-analysis of Alzheimer's Disease (Bellenguez, 2022), there is at least 1 LACTB SNP that are significantly associatied with Alzheimer's Disease:
• rs34367270 (GWAS p-value: 1.39e-08; b-value: 0.0471) | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'LACTB' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1446595', 'Gene': 'LACTB', 'topRSID': 'rs34367270', 'p_GWAS': 1.389329e-08, 'b_GWAS': 0.0471}] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.1456 | Q10 | Are there any LRRC37A SNPs that have a statistically significant association with Progressive supranuclear palsy? | Yes, according to genome-wide analysis of Progressive supranuclear palsy (Höglinger et al., 2011), there are at least 5 LRRC37A SNPs that are significantly associatied with Progressive supranuclear palsy:
• rs7225002 (GWAS p-value: 1.75e-11; b-value: -0.3874)
• rs8070723 (GWAS p-value: 2.23e-51; b-value: -1.704)
• rs1981997 (GWAS p-value: 1.79e-51; b-value: 1.715)
• rs17692129 (GWAS p-value: 5.79e-22; b-value: -0.5568)
• rs169201 (GWAS p-value: 8.55e-46; b-value: -1.588) | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'LRRC37A' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1444274', 'Gene': 'LRRC37A', 'topRSID': 'rs1981997', 'p_GWAS': 1.792216e-51, 'b_GWAS': 1.7146}, {'UUID': 'NDD_SMR_genes_all_update_text_30482', 'Gene': 'LRRC37A', 'topRSID': 'rs8070723', 'p_GWAS': 2.234221e-51, 'b_GWAS': -1.7039}, {'UUID': 'NDD_SMR_genes_all_update_text_1646048', 'Gene': 'LRRC37A', 'topRSID': 'rs169201', 'p_GWAS': 8.550985e-46, 'b_GWAS': -1.5881}, {'UUID': 'NDD_SMR_genes_all_update_text_1579426', 'Gene': 'LRRC37A', 'topRSID': 'rs17692129', 'p_GWAS': 5.788764e-22, 'b_GWAS': -0.5568}, {'UUID': 'NDD_SMR_genes_all_update_text_1170877', 'Gene': 'LRRC37A', 'topRSID': 'rs7225002', 'p_GWAS': 1.747569e-11, 'b_GWAS': 0.3874}, {'UUID': 'NDD_SMR_genes_all_update_text_1336296', 'Gene': 'LRRC37A', 'topRSID': 'rs7225002', 'p_GWAS': 1.747569e-11, 'b_GWAS': 0.3874}, {'UUID': 'NDD_SMR_genes_all_update_text_1388485', 'Gene': 'LRRC37A', 'topRSID': 'rs7225002', 'p_GWAS': 1.747569e-11, 'b_GWAS': 0.3874}, {'UUID': 'NDD_SMR_genes_all_update_text_22218', 'Gene': 'LRRC37A', 'topRSID': 'rs7225002', 'p_GWAS': 1.747569e-11, 'b_GWAS': -0.3874}, {'UUID': 'NDD_SMR_genes_all_update_text_1154398', 'Gene': 'LRRC37A', 'topRSID': 'rs7225002', 'p_GWAS': 1.747569e-11, 'b_GWAS': -0.3874}, {'UUID': 'NDD_SMR_genes_all_update_text_1283708', 'Gene': 'LRRC37A', 'topRSID': 'rs7225002', 'p_GWAS': 1.747569e-11, 'b_GWAS': 0.3874}, {'UUID': 'NDD_SMR_genes_all_update_text_1596827', 'Gene': 'LRRC37A', 'topRSID': 'rs7225002', 'p_GWAS': 1.747569e-11, 'b_GWAS': 0.3874}, {'UUID': 'NDD_SMR_genes_all_update_text_1464422', 'Gene': 'LRRC37A', 'topRSID': 'rs7225002', 'p_GWAS': 1.747569e-11, 'b_GWAS': 0.3874}, {'UUID': 'NDD_SMR_genes_all_update_text_1478191', 'Gene': 'LRRC37A', 'topRSID': 'rs7225002', 'p_GWAS': 1.747569e-11, 'b_GWAS': 0.3874}, {'UUID': 'NDD_SMR_genes_all_update_text_1452485', 'Gene': 'LRRC37A', 'topRSID': 'rs7225002', 'p_GWAS': 1.747569e-11, 'b_GWAS': 0.3874}, {'UUID': 'NDD_SMR_genes_all_update_text_1489542', 'Gene': 'LRRC37A', 'topRSID': 'rs7225002', 'p_GWAS': 1.747569e-11, 'b_GWAS': 0.3874}, {'UUID': 'NDD_SMR_genes_all_update_text_1714161', 'Gene': 'LRRC37A', 'topRSID': 'rs7225002', 'p_GWAS': 1.747569e-11, 'b_GWAS': 0.3874}, {'UUID': 'NDD_SMR_genes_all_update_text_1264987', 'Gene': 'LRRC37A', 'topRSID': 'rs7225002', 'p_GWAS': 1.747569e-11, 'b_GWAS': 0.3874}, {'UUID': 'NDD_SMR_genes_all_update_text_33472', 'Gene': 'LRRC37A', 'topRSID': 'rs7225002', 'p_GWAS': 1.747569e-11, 'b_GWAS': 0.3874}, {'UUID': 'NDD_SMR_genes_all_update_text_27913', 'Gene': 'LRRC37A', 'topRSID': 'rs7225002', 'p_GWAS': 1.747569e-11, 'b_GWAS': 0.3874}, {'UUID': 'NDD_SMR_genes_all_update_text_1684939', 'Gene': 'LRRC37A', 'topRSID': 'rs7225002', 'p_GWAS': 1.747569e-11, 'b_GWAS': 0.3874}, {'UUID': 'NDD_SMR_genes_all_update_text_1604717', 'Gene': 'LRRC37A', 'topRSID': 'rs7225002', 'p_GWAS': 1.747569e-11, 'b_GWAS': 0.3874}, {'UUID': 'NDD_SMR_genes_all_update_text_1375934', 'Gene': 'LRRC37A', 'topRSID': 'rs7225002', 'p_GWAS': 1.747569e-11, 'b_GWAS': 0.3874}, {'UUID': 'NDD_SMR_genes_all_update_text_1732400', 'Gene': 'LRRC37A', 'topRSID': 'rs7225002', 'p_GWAS': 1.747569e-11, 'b_GWAS': 0.3874}, {'UUID': 'NDD_SMR_genes_all_update_text_1194221', 'Gene': 'LRRC37A', 'topRSID': 'rs7225002', 'p_GWAS': 1.747569e-11, 'b_GWAS': 0.3874}] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.253 | Q10 | Are there any POLR2L SNPs that have a statistically significant association with Progressive supranuclear palsy? | No, according to genome-wide analysis of Progressive supranuclear palsy (Höglinger et al., 2011), there are no SNPs within POLR2L that are significantly associated with Progressive supranuclear palsy. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'POLR2L' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.419 | Q10 | Are there any CHRNA1 SNPs that have a statistically significant association with Alzheimer's Disease? | No, according to the largest European genome-wide meta-analysis of Alzheimer's Disease (Bellenguez, 2022), there are no SNPs within CHRNA1 that are significantly associated with Alzheimer's Disease. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'CHRNA1' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.1590 | Q10 | Are there any C8orf33 SNPs that have a statistically significant association with Amyotrophic Lateral Sclerosis? | No, according to genome-wide analysis of Amyotrophic Lateral Sclerosis (Nicolas et al., 2018), there are no SNPs within C8orf33 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'C8orf33' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.1895 | Q10 | Are there any GAK SNPs that have a statistically significant association with Alzheimer's Disease? | No, according to the largest European genome-wide meta-analysis of Alzheimer's Disease (Bellenguez, 2022), there are no SNPs within GAK that are significantly associated with Alzheimer's Disease. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'GAK' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.582 | Q10 | Are there any HSD17B2 SNPs that have a statistically significant association with Parkinson's Disease? | No, according to the largest European genome-wide meta-analysis of Parkinson's Disease (Nalls et al., 2019), there are no SNPs within HSD17B2 that are significantly associated with Parkinson's Disease. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'HSD17B2' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.314 | Q10 | Are there any C16orf45 SNPs that have a statistically significant association with Parkinson's Disease? | No, according to the largest European genome-wide meta-analysis of Parkinson's Disease (Nalls et al., 2019), there are no SNPs within C16orf45 that are significantly associated with Parkinson's Disease. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'C16orf45' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.1962 | Q10 | Are there any VAC14-AS1 SNPs that have a statistically significant association with Parkinson's Disease? | No, according to the largest European genome-wide meta-analysis of Parkinson's Disease (Nalls et al., 2019), there are no SNPs within VAC14-AS1 that are significantly associated with Parkinson's Disease. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'VAC14-AS1' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.387 | Q10 | Are there any ADORA2B SNPs that have a statistically significant association with Amyotrophic Lateral Sclerosis? | No, according to genome-wide analysis of Amyotrophic Lateral Sclerosis (Nicolas et al., 2018), there are no SNPs within ADORA2B that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'ADORA2B' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.541 | Q10 | Are there any KCTD13 SNPs that have a statistically significant association with Alzheimer's Disease? | No, according to the largest European genome-wide meta-analysis of Alzheimer's Disease (Bellenguez, 2022), there are no SNPs within KCTD13 that are significantly associated with Alzheimer's Disease. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'KCTD13' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.431 | Q10 | Are there any OR10AB1P SNPs that have a statistically significant association with Progressive supranuclear palsy? | No, according to genome-wide analysis of Progressive supranuclear palsy (Höglinger et al., 2011), there are no SNPs within OR10AB1P that are significantly associated with Progressive supranuclear palsy. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'OR10AB1P' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.657 | Q10 | Are there any C14orf142 SNPs that have a statistically significant association with Amyotrophic Lateral Sclerosis? | No, according to genome-wide analysis of Amyotrophic Lateral Sclerosis (Nicolas et al., 2018), there are no SNPs within C14orf142 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'C14orf142' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.1642 | Q10 | Are there any RP11-295M18.2 SNPs that have a statistically significant association with Amyotrophic Lateral Sclerosis? | No, according to genome-wide analysis of Amyotrophic Lateral Sclerosis (Nicolas et al., 2018), there are no SNPs within RP11-295M18.2 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'RP11-295M18.2' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.1318 | Q10 | Are there any SDCBP SNPs that have a statistically significant association with Amyotrophic Lateral Sclerosis? | No, according to genome-wide analysis of Amyotrophic Lateral Sclerosis (Nicolas et al., 2018), there are no SNPs within SDCBP that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'SDCBP' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.1358 | Q10 | Are there any CD2AP SNPs that have a statistically significant association with Alzheimer's Disease? | Yes, according to the largest European genome-wide meta-analysis of Alzheimer's Disease (Bellenguez, 2022), there are at least 6 CD2AP SNPs that are significantly associatied with Alzheimer's Disease:
• rs9349407 (GWAS p-value: 6.02e-12; b-value: 0.0626)
• rs1004173 (GWAS p-value: 7.03e-12; b-value: 0.0624)
• rs7738044 (GWAS p-value: 8.19e-12; b-value: 0.0622)
• rs13193054 (GWAS p-value: 9.55e-12; b-value: 0.062)
• rs13212790 (GWAS p-value: 1.03e-11; b-value: 0.0619)
• rs6931478 (GWAS p-value: 8.84e-12; b-value: 0.0621) | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'CD2AP' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_67370', 'Gene': 'CD2AP', 'topRSID': 'rs9349407', 'p_GWAS': 6.022304e-12, 'b_GWAS': 0.0626}, {'UUID': 'NDD_SMR_genes_all_update_text_67371', 'Gene': 'CD2AP', 'topRSID': 'rs1004173', 'p_GWAS': 7.025137e-12, 'b_GWAS': 0.0624}, {'UUID': 'NDD_SMR_genes_all_update_text_67374', 'Gene': 'CD2AP', 'topRSID': 'rs7738044', 'p_GWAS': 8.191079e-12, 'b_GWAS': 0.0622}, {'UUID': 'NDD_SMR_genes_all_update_text_622988', 'Gene': 'CD2AP', 'topRSID': 'rs6931478', 'p_GWAS': 8.843152e-12, 'b_GWAS': 0.0621}, {'UUID': 'NDD_SMR_genes_all_update_text_622985', 'Gene': 'CD2AP', 'topRSID': 'rs13193054', 'p_GWAS': 9.546005e-12, 'b_GWAS': 0.062}, {'UUID': 'NDD_SMR_genes_all_update_text_622986', 'Gene': 'CD2AP', 'topRSID': 'rs13212790', 'p_GWAS': 1.03035e-11, 'b_GWAS': 0.0619}] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.414 | Q10 | Are there any RP11-209E8.1 SNPs that have a statistically significant association with Progressive supranuclear palsy? | No, according to genome-wide analysis of Progressive supranuclear palsy (Höglinger et al., 2011), there are no SNPs within RP11-209E8.1 that are significantly associated with Progressive supranuclear palsy. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'RP11-209E8.1' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
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