Datasets:

uuid
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4
8
template_uuid
stringclasses
40 values
question
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13
193
answer
stringlengths
29
2.2k
benchmark_query
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627
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1.14M
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2 values
sql_category
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bio_category
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14 values
Q10.446
Q10
Are there any AK3P3 SNPs that have a statistically significant association with Parkinson's Disease?
No, according to the largest European genome-wide meta-analysis of Parkinson's Disease (Nalls et al., 2019), there are no SNPs within AK3P3 that are significantly associated with Parkinson's Disease.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'PD' AND Gene = 'AK3P3' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
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Q10.579
Q10
Are there any WHSC1 SNPs that have a statistically significant association with Amyotrophic Lateral Sclerosis?
No, according to genome-wide analysis of Amyotrophic Lateral Sclerosis (Nicolas et al., 2018), there are no SNPs within WHSC1 that are significantly associated with Amyotrophic Lateral Sclerosis.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'ALS' AND Gene = 'WHSC1' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
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Q10.955
Q10
Are there any LINC00263 SNPs that have a statistically significant association with Amyotrophic Lateral Sclerosis?
No, according to genome-wide analysis of Amyotrophic Lateral Sclerosis (Nicolas et al., 2018), there are no SNPs within LINC00263 that are significantly associated with Amyotrophic Lateral Sclerosis.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'ALS' AND Gene = 'LINC00263' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
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Q10.509
Q10
Are there any NDUFAF6 SNPs that have a statistically significant association with Alzheimer's Disease?
Yes, according to the largest European genome-wide meta-analysis of Alzheimer's Disease (Bellenguez, 2022), there is at least 12 NDUFAF6 SNP that are significantly associatied with Alzheimer's Disease: • rs896847 (GWAS p-value: 1.01e-08; b-value: -0.0464) • rs7815762 (GWAS p-value: 1.01e-08; b-value: -0.0464) • rs10098778 (GWAS p-value: 1.17e-08; b-value: -0.0462) • rs13278601 (GWAS p-value: 1.35e-08; b-value: 0.046) • rs6471503 (GWAS p-value: 1.81e-08; b-value: 0.0456) • rs13257021 (GWAS p-value: 2.40e-08; b-value: -0.0452) • rs10097617 (GWAS p-value: 2.97e-08; b-value: -0.0449) • rs6987752 (GWAS p-value: 2.99e-08; b-value: -0.046) • rs726816 (GWAS p-value: 3.31e-08; b-value: -0.0453) • rs896853 (GWAS p-value: 3.42e-08; b-value: -0.0447)
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'AD' AND Gene = 'NDUFAF6' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
[{'UUID': 'NDD_SMR_genes_all_update_text_1608133', 'Gene': 'NDUFAF6', 'topRSID': 'rs7815762', 'p_GWAS': 1.013852e-08, 'b_GWAS': -0.0464}, {'UUID': 'NDD_SMR_genes_all_update_text_1109758', 'Gene': 'NDUFAF6', 'topRSID': 'rs896847', 'p_GWAS': 1.013852e-08, 'b_GWAS': -0.0464}, {'UUID': 'NDD_SMR_genes_all_update_text_1393056', 'Gene': 'NDUFAF6', 'topRSID': 'rs896847', 'p_GWAS': 1.013852e-08, 'b_GWAS': 0.0464}, {'UUID': 'NDD_SMR_genes_all_update_text_1288273', 'Gene': 'NDUFAF6', 'topRSID': 'rs10098778', 'p_GWAS': 1.172318e-08, 'b_GWAS': 0.0462}, {'UUID': 'NDD_SMR_genes_all_update_text_79375', 'Gene': 'NDUFAF6', 'topRSID': 'rs10098778', 'p_GWAS': 1.172318e-08, 'b_GWAS': -0.0462}, {'UUID': 'NDD_SMR_genes_all_update_text_79378', 'Gene': 'NDUFAF6', 'topRSID': 'rs10098778', 'p_GWAS': 1.172318e-08, 'b_GWAS': -0.0462}, {'UUID': 'NDD_SMR_genes_all_update_text_1173066', 'Gene': 'NDUFAF6', 'topRSID': 'rs10098778', 'p_GWAS': 1.172318e-08, 'b_GWAS': 0.0462}, {'UUID': 'NDD_SMR_genes_all_update_text_1688154', 'Gene': 'NDUFAF6', 'topRSID': 'rs13278601', 'p_GWAS': 1.354747e-08, 'b_GWAS': 0.046}, {'UUID': 'NDD_SMR_genes_all_update_text_1583346', 'Gene': 'NDUFAF6', 'topRSID': 'rs6471503', 'p_GWAS': 1.80597e-08, 'b_GWAS': 0.0456}, {'UUID': 'NDD_SMR_genes_all_update_text_616797', 'Gene': 'NDUFAF6', 'topRSID': 'rs13257021', 'p_GWAS': 2.401774e-08, 'b_GWAS': -0.0452}, {'UUID': 'NDD_SMR_genes_all_update_text_79381', 'Gene': 'NDUFAF6', 'topRSID': 'rs10097617', 'p_GWAS': 2.969765e-08, 'b_GWAS': -0.0449}, {'UUID': 'NDD_SMR_genes_all_update_text_616799', 'Gene': 'NDUFAF6', 'topRSID': 'rs6987752', 'p_GWAS': 2.987483e-08, 'b_GWAS': -0.046}, {'UUID': 'NDD_SMR_genes_all_update_text_616800', 'Gene': 'NDUFAF6', 'topRSID': 'rs6987752', 'p_GWAS': 2.987483e-08, 'b_GWAS': -0.046}, {'UUID': 'NDD_SMR_genes_all_update_text_616795', 'Gene': 'NDUFAF6', 'topRSID': 'rs6987752', 'p_GWAS': 2.987483e-08, 'b_GWAS': -0.046}, {'UUID': 'NDD_SMR_genes_all_update_text_616796', 'Gene': 'NDUFAF6', 'topRSID': 'rs6987752', 'p_GWAS': 2.987483e-08, 'b_GWAS': -0.046}, {'UUID': 'NDD_SMR_genes_all_update_text_79376', 'Gene': 'NDUFAF6', 'topRSID': 'rs726816', 'p_GWAS': 3.306318e-08, 'b_GWAS': -0.0453}, {'UUID': 'NDD_SMR_genes_all_update_text_79377', 'Gene': 'NDUFAF6', 'topRSID': 'rs896853', 'p_GWAS': 3.418695e-08, 'b_GWAS': -0.0447}, {'UUID': 'NDD_SMR_genes_all_update_text_79382', 'Gene': 'NDUFAF6', 'topRSID': 'rs896853', 'p_GWAS': 3.418695e-08, 'b_GWAS': -0.0447}, {'UUID': 'NDD_SMR_genes_all_update_text_79379', 'Gene': 'NDUFAF6', 'topRSID': 'rs896853', 'p_GWAS': 3.418695e-08, 'b_GWAS': -0.0447}, {'UUID': 'NDD_SMR_genes_all_update_text_79374', 'Gene': 'NDUFAF6', 'topRSID': 'rs896853', 'p_GWAS': 3.418695e-08, 'b_GWAS': -0.0447}, {'UUID': 'NDD_SMR_genes_all_update_text_616793', 'Gene': 'NDUFAF6', 'topRSID': 'rs896853', 'p_GWAS': 3.418695e-08, 'b_GWAS': -0.0447}, {'UUID': 'NDD_SMR_genes_all_update_text_79380', 'Gene': 'NDUFAF6', 'topRSID': 'rs896853', 'p_GWAS': 3.418695e-08, 'b_GWAS': -0.0447}, {'UUID': 'NDD_SMR_genes_all_update_text_616794', 'Gene': 'NDUFAF6', 'topRSID': 'rs2879813', 'p_GWAS': 3.933154e-08, 'b_GWAS': -0.0445}, {'UUID': 'NDD_SMR_genes_all_update_text_616798', 'Gene': 'NDUFAF6', 'topRSID': 'rs1320164', 'p_GWAS': 3.933154e-08, 'b_GWAS': -0.0445}]
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Q10.612
Q10
Are there any SPI1 SNPs that have a statistically significant association with Alzheimer's Disease?
Yes, according to the largest European genome-wide meta-analysis of Alzheimer's Disease (Bellenguez, 2022), there is at least 1 SPI1 SNP that are significantly associatied with Alzheimer's Disease: • rs12801188 (GWAS p-value: 1.70e-09; b-value: 0.0506)
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'AD' AND Gene = 'SPI1' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
[{'UUID': 'NDD_SMR_genes_all_update_text_608486', 'Gene': 'SPI1', 'topRSID': 'rs12801188', 'p_GWAS': 1.703588e-09, 'b_GWAS': 0.0506}]
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Q10.1864
Q10
Are there any XXbac-B476C20.9 SNPs that have a statistically significant association with Amyotrophic Lateral Sclerosis?
No, according to genome-wide analysis of Amyotrophic Lateral Sclerosis (Nicolas et al., 2018), there are no SNPs within XXbac-B476C20.9 that are significantly associated with Amyotrophic Lateral Sclerosis.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'ALS' AND Gene = 'XXbac-B476C20.9' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
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Q10.1725
Q10
Are there any KCTD21 SNPs that have a statistically significant association with Parkinson's Disease?
No, according to the largest European genome-wide meta-analysis of Parkinson's Disease (Nalls et al., 2019), there are no SNPs within KCTD21 that are significantly associated with Parkinson's Disease.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'PD' AND Gene = 'KCTD21' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
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Q10.1885
Q10
Are there any MTF2 SNPs that have a statistically significant association with Parkinson's Disease?
No, according to the largest European genome-wide meta-analysis of Parkinson's Disease (Nalls et al., 2019), there are no SNPs within MTF2 that are significantly associated with Parkinson's Disease.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'PD' AND Gene = 'MTF2' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
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Q10.853
Q10
Are there any RNASE11 SNPs that have a statistically significant association with Parkinson's Disease?
No, according to the largest European genome-wide meta-analysis of Parkinson's Disease (Nalls et al., 2019), there are no SNPs within RNASE11 that are significantly associated with Parkinson's Disease.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'PD' AND Gene = 'RNASE11' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
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Q10.4
Q10
Are there any PPP1R3A SNPs that have a statistically significant association with Alzheimer's Disease?
No, according to the largest European genome-wide meta-analysis of Alzheimer's Disease (Bellenguez, 2022), there are no SNPs within PPP1R3A that are significantly associated with Alzheimer's Disease.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'AD' AND Gene = 'PPP1R3A' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
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Q10.1569
Q10
Are there any RP11-108M9.4 SNPs that have a statistically significant association with Amyotrophic Lateral Sclerosis?
No, according to genome-wide analysis of Amyotrophic Lateral Sclerosis (Nicolas et al., 2018), there are no SNPs within RP11-108M9.4 that are significantly associated with Amyotrophic Lateral Sclerosis.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'ALS' AND Gene = 'RP11-108M9.4' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
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Q10.1461
Q10
Are there any CCDC30 SNPs that have a statistically significant association with Amyotrophic Lateral Sclerosis?
No, according to genome-wide analysis of Amyotrophic Lateral Sclerosis (Nicolas et al., 2018), there are no SNPs within CCDC30 that are significantly associated with Amyotrophic Lateral Sclerosis.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'ALS' AND Gene = 'CCDC30' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
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Q10.473
Q10
Are there any RP11-307C19.3 SNPs that have a statistically significant association with Progressive supranuclear palsy?
No, according to genome-wide analysis of Progressive supranuclear palsy (Höglinger et al., 2011), there are no SNPs within RP11-307C19.3 that are significantly associated with Progressive supranuclear palsy.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'PSP' AND Gene = 'RP11-307C19.3' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
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Q10.325
Q10
Are there any ARL17B SNPs that have a statistically significant association with Alzheimer's Disease?
Yes, according to the largest European genome-wide meta-analysis of Alzheimer's Disease (Bellenguez, 2022), there are at least 5 ARL17B SNPs that are significantly associatied with Alzheimer's Disease: • rs7225002 (GWAS p-value: 1.63e-10; b-value: 0.0537) • rs199533 (GWAS p-value: 1.29e-08; b-value: -0.0563) • rs199451 (GWAS p-value: 2.85e-09; b-value: 0.0594) • rs538628 (GWAS p-value: 3.86e-09; b-value: 0.0589) • rs4510068 (GWAS p-value: 1.33e-10; b-value: -0.0546)
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'AD' AND Gene = 'ARL17B' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
[{'UUID': 'NDD_SMR_genes_all_update_text_1690050', 'Gene': 'ARL17B', 'topRSID': 'rs4510068', 'p_GWAS': 1.331504e-10, 'b_GWAS': -0.0546}, {'UUID': 'NDD_SMR_genes_all_update_text_2659', 'Gene': 'ARL17B', 'topRSID': 'rs7225002', 'p_GWAS': 1.628144e-10, 'b_GWAS': 0.0537}, {'UUID': 'NDD_SMR_genes_all_update_text_28415', 'Gene': 'ARL17B', 'topRSID': 'rs199451', 'p_GWAS': 2.850221e-09, 'b_GWAS': 0.0594}, {'UUID': 'NDD_SMR_genes_all_update_text_1106832', 'Gene': 'ARL17B', 'topRSID': 'rs538628', 'p_GWAS': 3.861956e-09, 'b_GWAS': 0.0589}, {'UUID': 'NDD_SMR_genes_all_update_text_24567', 'Gene': 'ARL17B', 'topRSID': 'rs199533', 'p_GWAS': 1.293899e-08, 'b_GWAS': -0.0563}, {'UUID': 'NDD_SMR_genes_all_update_text_30834', 'Gene': 'ARL17B', 'topRSID': 'rs199533', 'p_GWAS': 1.293899e-08, 'b_GWAS': 0.0563}]
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Q10.6
Q10
Are there any TRIM51BP SNPs that have a statistically significant association with Amyotrophic Lateral Sclerosis?
No, according to genome-wide analysis of Amyotrophic Lateral Sclerosis (Nicolas et al., 2018), there are no SNPs within TRIM51BP that are significantly associated with Amyotrophic Lateral Sclerosis.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'ALS' AND Gene = 'TRIM51BP' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
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Q10.225
Q10
Are there any RP4-799P18.2 SNPs that have a statistically significant association with Parkinson's Disease?
No, according to the largest European genome-wide meta-analysis of Parkinson's Disease (Nalls et al., 2019), there are no SNPs within RP4-799P18.2 that are significantly associated with Parkinson's Disease.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'PD' AND Gene = 'RP4-799P18.2' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
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Q10.1376
Q10
Are there any FBXL19 SNPs that have a statistically significant association with Alzheimer's Disease?
No, according to the largest European genome-wide meta-analysis of Alzheimer's Disease (Bellenguez, 2022), there are no SNPs within FBXL19 that are significantly associated with Alzheimer's Disease.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'AD' AND Gene = 'FBXL19' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
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Q10.553
Q10
Are there any MRGPRX2 SNPs that have a statistically significant association with Alzheimer's Disease?
No, according to the largest European genome-wide meta-analysis of Alzheimer's Disease (Bellenguez, 2022), there are no SNPs within MRGPRX2 that are significantly associated with Alzheimer's Disease.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'AD' AND Gene = 'MRGPRX2' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
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Q10.231
Q10
Are there any AP001891.1 SNPs that have a statistically significant association with Amyotrophic Lateral Sclerosis?
No, according to genome-wide analysis of Amyotrophic Lateral Sclerosis (Nicolas et al., 2018), there are no SNPs within AP001891.1 that are significantly associated with Amyotrophic Lateral Sclerosis.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'ALS' AND Gene = 'AP001891.1' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
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Q10.40
Q10
Are there any PGAM1P3 SNPs that have a statistically significant association with Parkinson's Disease?
No, according to the largest European genome-wide meta-analysis of Parkinson's Disease (Nalls et al., 2019), there are no SNPs within PGAM1P3 that are significantly associated with Parkinson's Disease.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'PD' AND Gene = 'PGAM1P3' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
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Q10.548
Q10
Are there any CHADL SNPs that have a statistically significant association with Amyotrophic Lateral Sclerosis?
No, according to genome-wide analysis of Amyotrophic Lateral Sclerosis (Nicolas et al., 2018), there are no SNPs within CHADL that are significantly associated with Amyotrophic Lateral Sclerosis.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'ALS' AND Gene = 'CHADL' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
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Q10.245
Q10
Are there any C6orf10 SNPs that have a statistically significant association with Parkinson's Disease?
Yes, according to the largest European genome-wide meta-analysis of Parkinson's Disease (Nalls et al., 2019), there are at least 3 C6orf10 SNPs that are significantly associatied with Parkinson's Disease: • rs35265698 (GWAS p-value: 4.09e-11; b-value: -0.2) • rs601945 (GWAS p-value: 2.21e-10; b-value: -0.1853) • rs34855541 (GWAS p-value: 7.38e-11; b-value: -0.2032)
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'PD' AND Gene = 'C6orf10' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
[{'UUID': 'NDD_SMR_genes_all_update_text_992070', 'Gene': 'C6orf10', 'topRSID': 'rs35265698', 'p_GWAS': 4.093312e-11, 'b_GWAS': -0.2}, {'UUID': 'NDD_SMR_genes_all_update_text_992077', 'Gene': 'C6orf10', 'topRSID': 'rs35265698', 'p_GWAS': 4.093312e-11, 'b_GWAS': -0.2}, {'UUID': 'NDD_SMR_genes_all_update_text_992068', 'Gene': 'C6orf10', 'topRSID': 'rs35265698', 'p_GWAS': 4.093312e-11, 'b_GWAS': -0.2}, {'UUID': 'NDD_SMR_genes_all_update_text_992079', 'Gene': 'C6orf10', 'topRSID': 'rs35265698', 'p_GWAS': 4.093312e-11, 'b_GWAS': -0.2}, {'UUID': 'NDD_SMR_genes_all_update_text_992067', 'Gene': 'C6orf10', 'topRSID': 'rs35265698', 'p_GWAS': 4.093312e-11, 'b_GWAS': -0.2}, {'UUID': 'NDD_SMR_genes_all_update_text_992078', 'Gene': 'C6orf10', 'topRSID': 'rs35265698', 'p_GWAS': 4.093312e-11, 'b_GWAS': -0.2}, {'UUID': 'NDD_SMR_genes_all_update_text_992073', 'Gene': 'C6orf10', 'topRSID': 'rs34855541', 'p_GWAS': 7.375262e-11, 'b_GWAS': -0.2032}, {'UUID': 'NDD_SMR_genes_all_update_text_992071', 'Gene': 'C6orf10', 'topRSID': 'rs601945', 'p_GWAS': 2.211426e-10, 'b_GWAS': -0.1853}, {'UUID': 'NDD_SMR_genes_all_update_text_992072', 'Gene': 'C6orf10', 'topRSID': 'rs601945', 'p_GWAS': 2.211426e-10, 'b_GWAS': -0.1853}, {'UUID': 'NDD_SMR_genes_all_update_text_992076', 'Gene': 'C6orf10', 'topRSID': 'rs601945', 'p_GWAS': 2.211426e-10, 'b_GWAS': -0.1853}]
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Q10.905
Q10
Are there any AC009166.5 SNPs that have a statistically significant association with Parkinson's Disease?
No, according to the largest European genome-wide meta-analysis of Parkinson's Disease (Nalls et al., 2019), there are no SNPs within AC009166.5 that are significantly associated with Parkinson's Disease.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'PD' AND Gene = 'AC009166.5' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
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Q10.1429
Q10
Are there any AC009133.12 SNPs that have a statistically significant association with Parkinson's Disease?
No, according to the largest European genome-wide meta-analysis of Parkinson's Disease (Nalls et al., 2019), there are no SNPs within AC009133.12 that are significantly associated with Parkinson's Disease.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'PD' AND Gene = 'AC009133.12' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
[]
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GWAS Significance
Q10.139
Q10
Are there any KRTAP4-5 SNPs that have a statistically significant association with Parkinson's Disease?
No, according to the largest European genome-wide meta-analysis of Parkinson's Disease (Nalls et al., 2019), there are no SNPs within KRTAP4-5 that are significantly associated with Parkinson's Disease.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'PD' AND Gene = 'KRTAP4-5' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
[]
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GWAS Significance
Q10.1191
Q10
Are there any OAT SNPs that have a statistically significant association with Alzheimer's Disease?
No, according to the largest European genome-wide meta-analysis of Alzheimer's Disease (Bellenguez, 2022), there are no SNPs within OAT that are significantly associated with Alzheimer's Disease.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'AD' AND Gene = 'OAT' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
[]
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GWAS Significance
Q10.1757
Q10
Are there any PIK3R2 SNPs that have a statistically significant association with Progressive supranuclear palsy?
No, according to genome-wide analysis of Progressive supranuclear palsy (Höglinger et al., 2011), there are no SNPs within PIK3R2 that are significantly associated with Progressive supranuclear palsy.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'PSP' AND Gene = 'PIK3R2' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
[]
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GWAS Significance
Q10.1573
Q10
Are there any IGHV3-72 SNPs that have a statistically significant association with Alzheimer's Disease?
No, according to the largest European genome-wide meta-analysis of Alzheimer's Disease (Bellenguez, 2022), there are no SNPs within IGHV3-72 that are significantly associated with Alzheimer's Disease.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'AD' AND Gene = 'IGHV3-72' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
[]
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GWAS Significance
Q10.1443
Q10
Are there any RP11-344N10.5 SNPs that have a statistically significant association with Amyotrophic Lateral Sclerosis?
No, according to genome-wide analysis of Amyotrophic Lateral Sclerosis (Nicolas et al., 2018), there are no SNPs within RP11-344N10.5 that are significantly associated with Amyotrophic Lateral Sclerosis.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'ALS' AND Gene = 'RP11-344N10.5' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
[]
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GWAS Significance
Q10.836
Q10
Are there any CTD-2165H16.4 SNPs that have a statistically significant association with Alzheimer's Disease?
No, according to the largest European genome-wide meta-analysis of Alzheimer's Disease (Bellenguez, 2022), there are no SNPs within CTD-2165H16.4 that are significantly associated with Alzheimer's Disease.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'AD' AND Gene = 'CTD-2165H16.4' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
[]
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GWAS Significance
Q10.451
Q10
Are there any FAM92A1 SNPs that have a statistically significant association with Alzheimer's Disease?
No, according to the largest European genome-wide meta-analysis of Alzheimer's Disease (Bellenguez, 2022), there are no SNPs within FAM92A1 that are significantly associated with Alzheimer's Disease.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'AD' AND Gene = 'FAM92A1' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
[]
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GWAS Significance
Q10.849
Q10
Are there any GTF2H2B SNPs that have a statistically significant association with Progressive supranuclear palsy?
No, according to genome-wide analysis of Progressive supranuclear palsy (Höglinger et al., 2011), there are no SNPs within GTF2H2B that are significantly associated with Progressive supranuclear palsy.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'PSP' AND Gene = 'GTF2H2B' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
[]
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GWAS Significance
Q10.1087
Q10
Are there any RP11-465N4.4 SNPs that have a statistically significant association with Parkinson's Disease?
No, according to the largest European genome-wide meta-analysis of Parkinson's Disease (Nalls et al., 2019), there are no SNPs within RP11-465N4.4 that are significantly associated with Parkinson's Disease.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'PD' AND Gene = 'RP11-465N4.4' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
[]
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GWAS Significance
Q10.1420
Q10
Are there any SLC16A9 SNPs that have a statistically significant association with Progressive supranuclear palsy?
No, according to genome-wide analysis of Progressive supranuclear palsy (Höglinger et al., 2011), there are no SNPs within SLC16A9 that are significantly associated with Progressive supranuclear palsy.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'PSP' AND Gene = 'SLC16A9' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
[]
refined
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GWAS Significance
Q10.1154
Q10
Are there any NLRC3 SNPs that have a statistically significant association with Parkinson's Disease?
No, according to the largest European genome-wide meta-analysis of Parkinson's Disease (Nalls et al., 2019), there are no SNPs within NLRC3 that are significantly associated with Parkinson's Disease.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'PD' AND Gene = 'NLRC3' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
[]
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GWAS Significance
Q10.1826
Q10
Are there any ATP6V1E1 SNPs that have a statistically significant association with Alzheimer's Disease?
No, according to the largest European genome-wide meta-analysis of Alzheimer's Disease (Bellenguez, 2022), there are no SNPs within ATP6V1E1 that are significantly associated with Alzheimer's Disease.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'AD' AND Gene = 'ATP6V1E1' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
[]
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GWAS Significance
Q10.588
Q10
Are there any VKORC1L1 SNPs that have a statistically significant association with Progressive supranuclear palsy?
No, according to genome-wide analysis of Progressive supranuclear palsy (Höglinger et al., 2011), there are no SNPs within VKORC1L1 that are significantly associated with Progressive supranuclear palsy.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'PSP' AND Gene = 'VKORC1L1' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
[]
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GWAS Significance
Q10.1892
Q10
Are there any GCSHP4 SNPs that have a statistically significant association with Alzheimer's Disease?
No, according to the largest European genome-wide meta-analysis of Alzheimer's Disease (Bellenguez, 2022), there are no SNPs within GCSHP4 that are significantly associated with Alzheimer's Disease.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'AD' AND Gene = 'GCSHP4' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
[]
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GWAS Significance
Q10.1970
Q10
Are there any DLGAP1-AS3 SNPs that have a statistically significant association with Progressive supranuclear palsy?
No, according to genome-wide analysis of Progressive supranuclear palsy (Höglinger et al., 2011), there are no SNPs within DLGAP1-AS3 that are significantly associated with Progressive supranuclear palsy.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'PSP' AND Gene = 'DLGAP1-AS3' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
[]
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GWAS Significance
Q10.668
Q10
Are there any TBPL2 SNPs that have a statistically significant association with Alzheimer's Disease?
No, according to the largest European genome-wide meta-analysis of Alzheimer's Disease (Bellenguez, 2022), there are no SNPs within TBPL2 that are significantly associated with Alzheimer's Disease.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'AD' AND Gene = 'TBPL2' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
[]
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GWAS Significance
Q10.442
Q10
Are there any HDAC11 SNPs that have a statistically significant association with Progressive supranuclear palsy?
No, according to genome-wide analysis of Progressive supranuclear palsy (Höglinger et al., 2011), there are no SNPs within HDAC11 that are significantly associated with Progressive supranuclear palsy.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'PSP' AND Gene = 'HDAC11' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
[]
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GWAS Significance
Q10.1857
Q10
Are there any LINC00304 SNPs that have a statistically significant association with Alzheimer's Disease?
No, according to the largest European genome-wide meta-analysis of Alzheimer's Disease (Bellenguez, 2022), there are no SNPs within LINC00304 that are significantly associated with Alzheimer's Disease.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'AD' AND Gene = 'LINC00304' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
[]
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GWAS Significance
Q10.382
Q10
Are there any CRTC1 SNPs that have a statistically significant association with Parkinson's Disease?
No, according to the largest European genome-wide meta-analysis of Parkinson's Disease (Nalls et al., 2019), there are no SNPs within CRTC1 that are significantly associated with Parkinson's Disease.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'PD' AND Gene = 'CRTC1' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
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GWAS Significance
Q10.1478
Q10
Are there any EPHA1 SNPs that have a statistically significant association with Alzheimer's Disease?
Yes, according to the largest European genome-wide meta-analysis of Alzheimer's Disease (Bellenguez, 2022), there is at least 1 EPHA1 SNP that are significantly associatied with Alzheimer's Disease: • rs3935067 (GWAS p-value: 1.08e-08; b-value: 0.0486)
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'AD' AND Gene = 'EPHA1' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
[{'UUID': 'NDD_SMR_genes_all_update_text_75159', 'Gene': 'EPHA1', 'topRSID': 'rs3935067', 'p_GWAS': 1.080092e-08, 'b_GWAS': 0.0486}, {'UUID': 'NDD_SMR_genes_all_update_text_587065', 'Gene': 'EPHA1', 'topRSID': 'rs3935067', 'p_GWAS': 1.080092e-08, 'b_GWAS': 0.0486}, {'UUID': 'NDD_SMR_genes_all_update_text_587066', 'Gene': 'EPHA1', 'topRSID': 'rs3935067', 'p_GWAS': 1.080092e-08, 'b_GWAS': 0.0486}]
refined
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GWAS Significance
Q10.974
Q10
Are there any KIAA1614 SNPs that have a statistically significant association with Progressive supranuclear palsy?
Yes, according to genome-wide analysis of Progressive supranuclear palsy (Höglinger et al., 2011), there is at least 1 KIAA1614 SNP that are significantly associatied with Progressive supranuclear palsy: • rs1411478 (GWAS p-value: 1.86e-09; b-value: -0.3191)
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'PSP' AND Gene = 'KIAA1614' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
[{'UUID': 'NDD_SMR_genes_all_update_text_509721', 'Gene': 'KIAA1614', 'topRSID': 'rs1411478', 'p_GWAS': 1.861926e-09, 'b_GWAS': -0.3191}, {'UUID': 'NDD_SMR_genes_all_update_text_1331138', 'Gene': 'KIAA1614', 'topRSID': 'rs1411478', 'p_GWAS': 1.861926e-09, 'b_GWAS': 0.3191}, {'UUID': 'NDD_SMR_genes_all_update_text_1730843', 'Gene': 'KIAA1614', 'topRSID': 'rs1411478', 'p_GWAS': 1.861926e-09, 'b_GWAS': 0.3191}]
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GWAS Significance
Q10.1210
Q10
Are there any IFNL4 SNPs that have a statistically significant association with Alzheimer's Disease?
No, according to the largest European genome-wide meta-analysis of Alzheimer's Disease (Bellenguez, 2022), there are no SNPs within IFNL4 that are significantly associated with Alzheimer's Disease.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'AD' AND Gene = 'IFNL4' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
[]
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GWAS Significance
Q10.318
Q10
Are there any SNORA31 SNPs that have a statistically significant association with Alzheimer's Disease?
No, according to the largest European genome-wide meta-analysis of Alzheimer's Disease (Bellenguez, 2022), there are no SNPs within SNORA31 that are significantly associated with Alzheimer's Disease.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'AD' AND Gene = 'SNORA31' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
[]
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GWAS Significance
Q10.698
Q10
Are there any STH SNPs that have a statistically significant association with Alzheimer's Disease?
Yes, according to the largest European genome-wide meta-analysis of Alzheimer's Disease (Bellenguez, 2022), there is at least 1 STH SNP that are significantly associatied with Alzheimer's Disease: • rs3785884 (GWAS p-value: 1.27e-08; b-value: 0.0552)
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'AD' AND Gene = 'STH' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
[{'UUID': 'NDD_SMR_genes_all_update_text_1106829', 'Gene': 'STH', 'topRSID': 'rs3785884', 'p_GWAS': 1.265036e-08, 'b_GWAS': 0.0552}]
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Distinct, Multi-Filter, Order By
GWAS Significance
Q10.1505
Q10
Are there any MS4A6E SNPs that have a statistically significant association with Alzheimer's Disease?
Yes, according to the largest European genome-wide meta-analysis of Alzheimer's Disease (Bellenguez, 2022), there is at least 1 MS4A6E SNP that are significantly associatied with Alzheimer's Disease: • rs10792267 (GWAS p-value: 1.85e-11; b-value: -0.0571)
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'AD' AND Gene = 'MS4A6E' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
[{'UUID': 'NDD_SMR_genes_all_update_text_91396', 'Gene': 'MS4A6E', 'topRSID': 'rs10792267', 'p_GWAS': 1.846823e-11, 'b_GWAS': -0.0571}, {'UUID': 'NDD_SMR_genes_all_update_text_91397', 'Gene': 'MS4A6E', 'topRSID': 'rs10792267', 'p_GWAS': 1.846823e-11, 'b_GWAS': -0.0571}]
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GWAS Significance
Q10.430
Q10
Are there any RGL1 SNPs that have a statistically significant association with Parkinson's Disease?
No, according to the largest European genome-wide meta-analysis of Parkinson's Disease (Nalls et al., 2019), there are no SNPs within RGL1 that are significantly associated with Parkinson's Disease.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'PD' AND Gene = 'RGL1' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
[]
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GWAS Significance
Q10.601
Q10
Are there any NUDT16 SNPs that have a statistically significant association with Amyotrophic Lateral Sclerosis?
No, according to genome-wide analysis of Amyotrophic Lateral Sclerosis (Nicolas et al., 2018), there are no SNPs within NUDT16 that are significantly associated with Amyotrophic Lateral Sclerosis.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'ALS' AND Gene = 'NUDT16' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
[]
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GWAS Significance
Q10.1964
Q10
Are there any FBXW11P1 SNPs that have a statistically significant association with Parkinson's Disease?
No, according to the largest European genome-wide meta-analysis of Parkinson's Disease (Nalls et al., 2019), there are no SNPs within FBXW11P1 that are significantly associated with Parkinson's Disease.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'PD' AND Gene = 'FBXW11P1' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
[]
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GWAS Significance
Q10.629
Q10
Are there any EZR-AS1 SNPs that have a statistically significant association with Alzheimer's Disease?
No, according to the largest European genome-wide meta-analysis of Alzheimer's Disease (Bellenguez, 2022), there are no SNPs within EZR-AS1 that are significantly associated with Alzheimer's Disease.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'AD' AND Gene = 'EZR-AS1' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
[]
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GWAS Significance
Q10.1170
Q10
Are there any C1orf194 SNPs that have a statistically significant association with Amyotrophic Lateral Sclerosis?
No, according to genome-wide analysis of Amyotrophic Lateral Sclerosis (Nicolas et al., 2018), there are no SNPs within C1orf194 that are significantly associated with Amyotrophic Lateral Sclerosis.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'ALS' AND Gene = 'C1orf194' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
[]
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GWAS Significance
Q10.1254
Q10
Are there any RP11-620J15.3 SNPs that have a statistically significant association with Amyotrophic Lateral Sclerosis?
No, according to genome-wide analysis of Amyotrophic Lateral Sclerosis (Nicolas et al., 2018), there are no SNPs within RP11-620J15.3 that are significantly associated with Amyotrophic Lateral Sclerosis.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'ALS' AND Gene = 'RP11-620J15.3' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
[]
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GWAS Significance
Q10.230
Q10
Are there any AC005606.15 SNPs that have a statistically significant association with Alzheimer's Disease?
No, according to the largest European genome-wide meta-analysis of Alzheimer's Disease (Bellenguez, 2022), there are no SNPs within AC005606.15 that are significantly associated with Alzheimer's Disease.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'AD' AND Gene = 'AC005606.15' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
[]
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GWAS Significance
Q10.1180
Q10
Are there any IGHV3-73 SNPs that have a statistically significant association with Alzheimer's Disease?
No, according to the largest European genome-wide meta-analysis of Alzheimer's Disease (Bellenguez, 2022), there are no SNPs within IGHV3-73 that are significantly associated with Alzheimer's Disease.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'AD' AND Gene = 'IGHV3-73' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
[]
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GWAS Significance
Q10.1332
Q10
Are there any WDR5 SNPs that have a statistically significant association with Parkinson's Disease?
No, according to the largest European genome-wide meta-analysis of Parkinson's Disease (Nalls et al., 2019), there are no SNPs within WDR5 that are significantly associated with Parkinson's Disease.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'PD' AND Gene = 'WDR5' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
[]
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GWAS Significance
Q10.1587
Q10
Are there any AC007163.8 SNPs that have a statistically significant association with Amyotrophic Lateral Sclerosis?
No, according to genome-wide analysis of Amyotrophic Lateral Sclerosis (Nicolas et al., 2018), there are no SNPs within AC007163.8 that are significantly associated with Amyotrophic Lateral Sclerosis.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'ALS' AND Gene = 'AC007163.8' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
[]
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GWAS Significance
Q10.69
Q10
Are there any SH3BP5L SNPs that have a statistically significant association with Alzheimer's Disease?
No, according to the largest European genome-wide meta-analysis of Alzheimer's Disease (Bellenguez, 2022), there are no SNPs within SH3BP5L that are significantly associated with Alzheimer's Disease.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'AD' AND Gene = 'SH3BP5L' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
[]
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GWAS Significance
Q10.25
Q10
Are there any ARMC2 SNPs that have a statistically significant association with Amyotrophic Lateral Sclerosis?
No, according to genome-wide analysis of Amyotrophic Lateral Sclerosis (Nicolas et al., 2018), there are no SNPs within ARMC2 that are significantly associated with Amyotrophic Lateral Sclerosis.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'ALS' AND Gene = 'ARMC2' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
[]
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GWAS Significance
Q10.147
Q10
Are there any AL392086.1 SNPs that have a statistically significant association with Alzheimer's Disease?
No, according to the largest European genome-wide meta-analysis of Alzheimer's Disease (Bellenguez, 2022), there are no SNPs within AL392086.1 that are significantly associated with Alzheimer's Disease.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'AD' AND Gene = 'AL392086.1' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
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Q10.542
Q10
Are there any SDS SNPs that have a statistically significant association with Parkinson's Disease?
No, according to the largest European genome-wide meta-analysis of Parkinson's Disease (Nalls et al., 2019), there are no SNPs within SDS that are significantly associated with Parkinson's Disease.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'PD' AND Gene = 'SDS' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
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Q10.818
Q10
Are there any LINC00313 SNPs that have a statistically significant association with Amyotrophic Lateral Sclerosis?
No, according to genome-wide analysis of Amyotrophic Lateral Sclerosis (Nicolas et al., 2018), there are no SNPs within LINC00313 that are significantly associated with Amyotrophic Lateral Sclerosis.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'ALS' AND Gene = 'LINC00313' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
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Q10.1120
Q10
Are there any PPOX SNPs that have a statistically significant association with Alzheimer's Disease?
No, according to the largest European genome-wide meta-analysis of Alzheimer's Disease (Bellenguez, 2022), there are no SNPs within PPOX that are significantly associated with Alzheimer's Disease.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'AD' AND Gene = 'PPOX' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
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Q10.88
Q10
Are there any CYCSP34 SNPs that have a statistically significant association with Alzheimer's Disease?
No, according to the largest European genome-wide meta-analysis of Alzheimer's Disease (Bellenguez, 2022), there are no SNPs within CYCSP34 that are significantly associated with Alzheimer's Disease.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'AD' AND Gene = 'CYCSP34' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
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Q10.1183
Q10
Are there any REXO1 SNPs that have a statistically significant association with Alzheimer's Disease?
Yes, according to the largest European genome-wide meta-analysis of Alzheimer's Disease (Bellenguez, 2022), there are at least 4 REXO1 SNPs that are significantly associatied with Alzheimer's Disease: • rs11669862 (GWAS p-value: 2.85e-08; b-value: -0.0494) • rs11667638 (GWAS p-value: 3.04e-08; b-value: 0.0493) • rs12977787 (GWAS p-value: 4.91e-08; b-value: -0.048) • rs11668832 (GWAS p-value: 2.26e-08; b-value: 0.0492)
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'AD' AND Gene = 'REXO1' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
[{'UUID': 'NDD_SMR_genes_all_update_text_1397198', 'Gene': 'REXO1', 'topRSID': 'rs11668832', 'p_GWAS': 2.258838e-08, 'b_GWAS': 0.0492}, {'UUID': 'NDD_SMR_genes_all_update_text_119558', 'Gene': 'REXO1', 'topRSID': 'rs11669862', 'p_GWAS': 2.84753e-08, 'b_GWAS': -0.0494}, {'UUID': 'NDD_SMR_genes_all_update_text_634425', 'Gene': 'REXO1', 'topRSID': 'rs11667638', 'p_GWAS': 3.036382e-08, 'b_GWAS': 0.0493}, {'UUID': 'NDD_SMR_genes_all_update_text_1107645', 'Gene': 'REXO1', 'topRSID': 'rs12977787', 'p_GWAS': 4.909828e-08, 'b_GWAS': -0.048}]
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Q10.1333
Q10
Are there any PSMD4 SNPs that have a statistically significant association with Parkinson's Disease?
No, according to the largest European genome-wide meta-analysis of Parkinson's Disease (Nalls et al., 2019), there are no SNPs within PSMD4 that are significantly associated with Parkinson's Disease.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'PD' AND Gene = 'PSMD4' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
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Q10.1806
Q10
Are there any GPR160 SNPs that have a statistically significant association with Parkinson's Disease?
No, according to the largest European genome-wide meta-analysis of Parkinson's Disease (Nalls et al., 2019), there are no SNPs within GPR160 that are significantly associated with Parkinson's Disease.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'PD' AND Gene = 'GPR160' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
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Q10.1819
Q10
Are there any PRIMA1 SNPs that have a statistically significant association with Alzheimer's Disease?
No, according to the largest European genome-wide meta-analysis of Alzheimer's Disease (Bellenguez, 2022), there are no SNPs within PRIMA1 that are significantly associated with Alzheimer's Disease.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'AD' AND Gene = 'PRIMA1' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
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Q10.1374
Q10
Are there any MSLN SNPs that have a statistically significant association with Amyotrophic Lateral Sclerosis?
No, according to genome-wide analysis of Amyotrophic Lateral Sclerosis (Nicolas et al., 2018), there are no SNPs within MSLN that are significantly associated with Amyotrophic Lateral Sclerosis.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'ALS' AND Gene = 'MSLN' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
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Q10.1144
Q10
Are there any USP46 SNPs that have a statistically significant association with Alzheimer's Disease?
No, according to the largest European genome-wide meta-analysis of Alzheimer's Disease (Bellenguez, 2022), there are no SNPs within USP46 that are significantly associated with Alzheimer's Disease.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'AD' AND Gene = 'USP46' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
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Q10.367
Q10
Are there any MIPOL1 SNPs that have a statistically significant association with Parkinson's Disease?
No, according to the largest European genome-wide meta-analysis of Parkinson's Disease (Nalls et al., 2019), there are no SNPs within MIPOL1 that are significantly associated with Parkinson's Disease.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'PD' AND Gene = 'MIPOL1' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
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Q10.1790
Q10
Are there any AP002856.5 SNPs that have a statistically significant association with Parkinson's Disease?
No, according to the largest European genome-wide meta-analysis of Parkinson's Disease (Nalls et al., 2019), there are no SNPs within AP002856.5 that are significantly associated with Parkinson's Disease.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'PD' AND Gene = 'AP002856.5' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
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Q10.1208
Q10
Are there any CTC-232P5.1 SNPs that have a statistically significant association with Alzheimer's Disease?
No, according to the largest European genome-wide meta-analysis of Alzheimer's Disease (Bellenguez, 2022), there are no SNPs within CTC-232P5.1 that are significantly associated with Alzheimer's Disease.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'AD' AND Gene = 'CTC-232P5.1' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
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Q10.1035
Q10
Are there any DPEP3 SNPs that have a statistically significant association with Progressive supranuclear palsy?
No, according to genome-wide analysis of Progressive supranuclear palsy (Höglinger et al., 2011), there are no SNPs within DPEP3 that are significantly associated with Progressive supranuclear palsy.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'PSP' AND Gene = 'DPEP3' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
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Q10.1039
Q10
Are there any LINC00297 SNPs that have a statistically significant association with Alzheimer's Disease?
No, according to the largest European genome-wide meta-analysis of Alzheimer's Disease (Bellenguez, 2022), there are no SNPs within LINC00297 that are significantly associated with Alzheimer's Disease.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'AD' AND Gene = 'LINC00297' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
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Q10.1761
Q10
Are there any RPL4P6 SNPs that have a statistically significant association with Alzheimer's Disease?
No, according to the largest European genome-wide meta-analysis of Alzheimer's Disease (Bellenguez, 2022), there are no SNPs within RPL4P6 that are significantly associated with Alzheimer's Disease.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'AD' AND Gene = 'RPL4P6' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
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Q10.1357
Q10
Are there any TBX5-AS1 SNPs that have a statistically significant association with Amyotrophic Lateral Sclerosis?
No, according to genome-wide analysis of Amyotrophic Lateral Sclerosis (Nicolas et al., 2018), there are no SNPs within TBX5-AS1 that are significantly associated with Amyotrophic Lateral Sclerosis.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'ALS' AND Gene = 'TBX5-AS1' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
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Q10.1875
Q10
Are there any SLC43A2 SNPs that have a statistically significant association with Alzheimer's Disease?
No, according to the largest European genome-wide meta-analysis of Alzheimer's Disease (Bellenguez, 2022), there are no SNPs within SLC43A2 that are significantly associated with Alzheimer's Disease.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'AD' AND Gene = 'SLC43A2' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
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Q10.672
Q10
Are there any novel_or_none SNPs that have a statistically significant association with Alzheimer's Disease?
Yes, according to the largest European genome-wide meta-analysis of Alzheimer's Disease (Bellenguez, 2022), there are at least 30 novel_or_none SNPs that are significantly associatied with Alzheimer's Disease: • rs6743470 (GWAS p-value: 3.42e-24; b-value: 0.1035) • rs2927472 (GWAS p-value: 3.61e-24; b-value: -0.1288) • rs11230187 (GWAS p-value: 1.64e-19; b-value: 0.0768) • rs7114331 (GWAS p-value: 9.02e-17; b-value: 0.0682) • rs601945 (GWAS p-value: 2.48e-16; b-value: -0.0918) • rs17057438 (GWAS p-value: 9.40e-15; b-value: -0.0674) • rs7821500 (GWAS p-value: 3.29e-14; b-value: 0.066) • rs11234552 (GWAS p-value: 4.90e-14; b-value: -0.0761) • rs1532279 (GWAS p-value: 2.66e-13; b-value: 0.0636) • rs56157503 (GWAS p-value: 7.46e-13; b-value: 0.0882)
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'AD' AND Gene = 'novel_or_none' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
[{'UUID': 'NDD_SMR_genes_all_update_text_46342', 'Gene': 'novel_or_none', 'topRSID': 'rs6743470', 'p_GWAS': 3.415004e-24, 'b_GWAS': 0.1035}, {'UUID': 'NDD_SMR_genes_all_update_text_637424', 'Gene': 'novel_or_none', 'topRSID': 'rs2927472', 'p_GWAS': 3.606466e-24, 'b_GWAS': -0.1288}, {'UUID': 'NDD_SMR_genes_all_update_text_637423', 'Gene': 'novel_or_none', 'topRSID': 'rs2927472', 'p_GWAS': 3.606466e-24, 'b_GWAS': -0.1288}, {'UUID': 'NDD_SMR_genes_all_update_text_91393', 'Gene': 'novel_or_none', 'topRSID': 'rs11230187', 'p_GWAS': 1.6356199999999998e-19, 'b_GWAS': 0.0768}, {'UUID': 'NDD_SMR_genes_all_update_text_610283', 'Gene': 'novel_or_none', 'topRSID': 'rs7114331', 'p_GWAS': 9.016209000000001e-17, 'b_GWAS': 0.0682}, {'UUID': 'NDD_SMR_genes_all_update_text_621711', 'Gene': 'novel_or_none', 'topRSID': 'rs601945', 'p_GWAS': 2.476343e-16, 'b_GWAS': -0.0918}, {'UUID': 'NDD_SMR_genes_all_update_text_78257', 'Gene': 'novel_or_none', 'topRSID': 'rs17057438', 'p_GWAS': 9.399535e-15, 'b_GWAS': -0.0674}, {'UUID': 'NDD_SMR_genes_all_update_text_615767', 'Gene': 'novel_or_none', 'topRSID': 'rs7821500', 'p_GWAS': 3.294063e-14, 'b_GWAS': 0.066}, {'UUID': 'NDD_SMR_genes_all_update_text_93002', 'Gene': 'novel_or_none', 'topRSID': 'rs11234552', 'p_GWAS': 4.896334e-14, 'b_GWAS': -0.0761}, {'UUID': 'NDD_SMR_genes_all_update_text_615768', 'Gene': 'novel_or_none', 'topRSID': 'rs1532279', 'p_GWAS': 2.664577e-13, 'b_GWAS': 0.0636}, {'UUID': 'NDD_SMR_genes_all_update_text_610284', 'Gene': 'novel_or_none', 'topRSID': 'rs56157503', 'p_GWAS': 7.459797e-13, 'b_GWAS': 0.0882}, {'UUID': 'NDD_SMR_genes_all_update_text_610285', 'Gene': 'novel_or_none', 'topRSID': 'rs10501610', 'p_GWAS': 1.262454e-12, 'b_GWAS': 0.0866}, {'UUID': 'NDD_SMR_genes_all_update_text_93001', 'Gene': 'novel_or_none', 'topRSID': 'rs565031', 'p_GWAS': 1.504499e-12, 'b_GWAS': -0.0573}, {'UUID': 'NDD_SMR_genes_all_update_text_78256', 'Gene': 'novel_or_none', 'topRSID': 'rs7012010', 'p_GWAS': 1.855363e-12, 'b_GWAS': -0.0627}, {'UUID': 'NDD_SMR_genes_all_update_text_78255', 'Gene': 'novel_or_none', 'topRSID': 'rs7012010', 'p_GWAS': 1.855363e-12, 'b_GWAS': -0.0627}, {'UUID': 'NDD_SMR_genes_all_update_text_78259', 'Gene': 'novel_or_none', 'topRSID': 'rs28661845', 'p_GWAS': 5.574931e-12, 'b_GWAS': -0.0627}, {'UUID': 'NDD_SMR_genes_all_update_text_615771', 'Gene': 'novel_or_none', 'topRSID': 'rs73229095', 'p_GWAS': 6.022304e-12, 'b_GWAS': 0.0626}, {'UUID': 'NDD_SMR_genes_all_update_text_615770', 'Gene': 'novel_or_none', 'topRSID': 'rs73229095', 'p_GWAS': 6.022304e-12, 'b_GWAS': 0.0626}, {'UUID': 'NDD_SMR_genes_all_update_text_615769', 'Gene': 'novel_or_none', 'topRSID': 'rs73229095', 'p_GWAS': 6.022304e-12, 'b_GWAS': 0.0626}, {'UUID': 'NDD_SMR_genes_all_update_text_591978', 'Gene': 'novel_or_none', 'topRSID': 'rs1800764', 'p_GWAS': 1.41758e-11, 'b_GWAS': -0.0554}, {'UUID': 'NDD_SMR_genes_all_update_text_78260', 'Gene': 'novel_or_none', 'topRSID': 'rs4732729', 'p_GWAS': 1.274089e-10, 'b_GWAS': -0.0553}, {'UUID': 'NDD_SMR_genes_all_update_text_66184', 'Gene': 'novel_or_none', 'topRSID': 'rs9268522', 'p_GWAS': 2.112365e-10, 'b_GWAS': -0.0648}, {'UUID': 'NDD_SMR_genes_all_update_text_85769', 'Gene': 'novel_or_none', 'topRSID': 'rs1361458', 'p_GWAS': 5.896165e-10, 'b_GWAS': 0.0545}, {'UUID': 'NDD_SMR_genes_all_update_text_631114', 'Gene': 'novel_or_none', 'topRSID': 'rs730306', 'p_GWAS': 1.284634e-09, 'b_GWAS': 0.0613}, {'UUID': 'NDD_SMR_genes_all_update_text_119561', 'Gene': 'novel_or_none', 'topRSID': 'rs11669170', 'p_GWAS': 1.810332e-08, 'b_GWAS': -0.0501}, {'UUID': 'NDD_SMR_genes_all_update_text_119560', 'Gene': 'novel_or_none', 'topRSID': 'rs11669170', 'p_GWAS': 1.810332e-08, 'b_GWAS': -0.0501}, {'UUID': 'NDD_SMR_genes_all_update_text_74020', 'Gene': 'novel_or_none', 'topRSID': 'rs10267212', 'p_GWAS': 2.061711e-08, 'b_GWAS': 0.0499}, {'UUID': 'NDD_SMR_genes_all_update_text_74017', 'Gene': 'novel_or_none', 'topRSID': 'rs6946168', 'p_GWAS': 2.143518e-08, 'b_GWAS': 0.0504}, {'UUID': 'NDD_SMR_genes_all_update_text_115144', 'Gene': 'novel_or_none', 'topRSID': 'rs17577975', 'p_GWAS': 2.194048e-08, 'b_GWAS': -0.0554}, {'UUID': 'NDD_SMR_genes_all_update_text_616933', 'Gene': 'novel_or_none', 'topRSID': 'rs1693571', 'p_GWAS': 2.501442e-08, 'b_GWAS': 0.0457}, {'UUID': 'NDD_SMR_genes_all_update_text_119574', 'Gene': 'novel_or_none', 'topRSID': 'rs34541064', 'p_GWAS': 2.84753e-08, 'b_GWAS': -0.0494}, {'UUID': 'NDD_SMR_genes_all_update_text_115227', 'Gene': 'novel_or_none', 'topRSID': 'rs2696610', 'p_GWAS': 3.29012e-08, 'b_GWAS': -0.0547}, {'UUID': 'NDD_SMR_genes_all_update_text_621721', 'Gene': 'novel_or_none', 'topRSID': 'rs2760994', 'p_GWAS': 3.427385e-08, 'b_GWAS': 0.0458}, {'UUID': 'NDD_SMR_genes_all_update_text_591228', 'Gene': 'novel_or_none', 'topRSID': 'rs2532233', 'p_GWAS': 3.690625e-08, 'b_GWAS': -0.0545}, {'UUID': 'NDD_SMR_genes_all_update_text_74018', 'Gene': 'novel_or_none', 'topRSID': 'rs10275052', 'p_GWAS': 3.797912e-08, 'b_GWAS': 0.0495}, {'UUID': 'NDD_SMR_genes_all_update_text_585966', 'Gene': 'novel_or_none', 'topRSID': 'rs10275052', 'p_GWAS': 3.797912e-08, 'b_GWAS': -0.0495}]
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GWAS Significance
Q10.369
Q10
Are there any VIL1 SNPs that have a statistically significant association with Parkinson's Disease?
No, according to the largest European genome-wide meta-analysis of Parkinson's Disease (Nalls et al., 2019), there are no SNPs within VIL1 that are significantly associated with Parkinson's Disease.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'PD' AND Gene = 'VIL1' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
[]
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GWAS Significance
Q10.80
Q10
Are there any CLEC4GP1 SNPs that have a statistically significant association with Alzheimer's Disease?
No, according to the largest European genome-wide meta-analysis of Alzheimer's Disease (Bellenguez, 2022), there are no SNPs within CLEC4GP1 that are significantly associated with Alzheimer's Disease.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'AD' AND Gene = 'CLEC4GP1' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
[]
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GWAS Significance
Q10.28
Q10
Are there any TRPC6 SNPs that have a statistically significant association with Amyotrophic Lateral Sclerosis?
No, according to genome-wide analysis of Amyotrophic Lateral Sclerosis (Nicolas et al., 2018), there are no SNPs within TRPC6 that are significantly associated with Amyotrophic Lateral Sclerosis.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'ALS' AND Gene = 'TRPC6' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
[]
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GWAS Significance
Q10.1438
Q10
Are there any SPDYE4 SNPs that have a statistically significant association with Progressive supranuclear palsy?
No, according to genome-wide analysis of Progressive supranuclear palsy (Höglinger et al., 2011), there are no SNPs within SPDYE4 that are significantly associated with Progressive supranuclear palsy.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'PSP' AND Gene = 'SPDYE4' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
[]
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GWAS Significance
Q10.531
Q10
Are there any RP11-350J20.9 SNPs that have a statistically significant association with Alzheimer's Disease?
No, according to the largest European genome-wide meta-analysis of Alzheimer's Disease (Bellenguez, 2022), there are no SNPs within RP11-350J20.9 that are significantly associated with Alzheimer's Disease.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'AD' AND Gene = 'RP11-350J20.9' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
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GWAS Significance
Q10.1836
Q10
Are there any CD101 SNPs that have a statistically significant association with Alzheimer's Disease?
No, according to the largest European genome-wide meta-analysis of Alzheimer's Disease (Bellenguez, 2022), there are no SNPs within CD101 that are significantly associated with Alzheimer's Disease.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'AD' AND Gene = 'CD101' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
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Q10.56
Q10
Are there any C1QTNF9B SNPs that have a statistically significant association with Amyotrophic Lateral Sclerosis?
No, according to genome-wide analysis of Amyotrophic Lateral Sclerosis (Nicolas et al., 2018), there are no SNPs within C1QTNF9B that are significantly associated with Amyotrophic Lateral Sclerosis.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'ALS' AND Gene = 'C1QTNF9B' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
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Q10.645
Q10
Are there any PRICKLE2 SNPs that have a statistically significant association with Amyotrophic Lateral Sclerosis?
No, according to genome-wide analysis of Amyotrophic Lateral Sclerosis (Nicolas et al., 2018), there are no SNPs within PRICKLE2 that are significantly associated with Amyotrophic Lateral Sclerosis.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'ALS' AND Gene = 'PRICKLE2' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
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Q10.306
Q10
Are there any CNN2 SNPs that have a statistically significant association with Alzheimer's Disease?
No, according to the largest European genome-wide meta-analysis of Alzheimer's Disease (Bellenguez, 2022), there are no SNPs within CNN2 that are significantly associated with Alzheimer's Disease.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'AD' AND Gene = 'CNN2' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
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Q10.725
Q10
Are there any PELI1 SNPs that have a statistically significant association with Amyotrophic Lateral Sclerosis?
No, according to genome-wide analysis of Amyotrophic Lateral Sclerosis (Nicolas et al., 2018), there are no SNPs within PELI1 that are significantly associated with Amyotrophic Lateral Sclerosis.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'ALS' AND Gene = 'PELI1' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
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Q10.631
Q10
Are there any ZNRF3 SNPs that have a statistically significant association with Progressive supranuclear palsy?
No, according to genome-wide analysis of Progressive supranuclear palsy (Höglinger et al., 2011), there are no SNPs within ZNRF3 that are significantly associated with Progressive supranuclear palsy.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'PSP' AND Gene = 'ZNRF3' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
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Q10.8
Q10
Are there any FLNB SNPs that have a statistically significant association with Parkinson's Disease?
No, according to the largest European genome-wide meta-analysis of Parkinson's Disease (Nalls et al., 2019), there are no SNPs within FLNB that are significantly associated with Parkinson's Disease.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'PD' AND Gene = 'FLNB' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
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Q10.810
Q10
Are there any REXO2 SNPs that have a statistically significant association with Alzheimer's Disease?
No, according to the largest European genome-wide meta-analysis of Alzheimer's Disease (Bellenguez, 2022), there are no SNPs within REXO2 that are significantly associated with Alzheimer's Disease.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'AD' AND Gene = 'REXO2' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
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Q10.1058
Q10
Are there any BZRAP1 SNPs that have a statistically significant association with Alzheimer's Disease?
Yes, according to the largest European genome-wide meta-analysis of Alzheimer's Disease (Bellenguez, 2022), there is at least 1 BZRAP1 SNP that are significantly associatied with Alzheimer's Disease: • rs2680700 (GWAS p-value: 9.57e-09; b-value: 0.0482)
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'AD' AND Gene = 'BZRAP1' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
[{'UUID': 'NDD_SMR_genes_all_update_text_115781', 'Gene': 'BZRAP1', 'topRSID': 'rs2680700', 'p_GWAS': 9.574727e-09, 'b_GWAS': 0.0482}]
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Q10.340
Q10
Are there any CDRT4 SNPs that have a statistically significant association with Progressive supranuclear palsy?
No, according to genome-wide analysis of Progressive supranuclear palsy (Höglinger et al., 2011), there are no SNPs within CDRT4 that are significantly associated with Progressive supranuclear palsy.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'PSP' AND Gene = 'CDRT4' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
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Q10.48
Q10
Are there any NR3C1 SNPs that have a statistically significant association with Progressive supranuclear palsy?
No, according to genome-wide analysis of Progressive supranuclear palsy (Höglinger et al., 2011), there are no SNPs within NR3C1 that are significantly associated with Progressive supranuclear palsy.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'PSP' AND Gene = 'NR3C1' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
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Q10.1481
Q10
Are there any ZBTB20-AS1 SNPs that have a statistically significant association with Amyotrophic Lateral Sclerosis?
No, according to genome-wide analysis of Amyotrophic Lateral Sclerosis (Nicolas et al., 2018), there are no SNPs within ZBTB20-AS1 that are significantly associated with Amyotrophic Lateral Sclerosis.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'ALS' AND Gene = 'ZBTB20-AS1' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
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Q10.109
Q10
Are there any RP11-67M1.1 SNPs that have a statistically significant association with Parkinson's Disease?
Yes, according to the largest European genome-wide meta-analysis of Parkinson's Disease (Nalls et al., 2019), there is at least 1 RP11-67M1.1 SNP that are significantly associatied with Parkinson's Disease: • rs1551980 (GWAS p-value: 1.45e-10; b-value: -0.1218)
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'PD' AND Gene = 'RP11-67M1.1' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
[{'UUID': 'NDD_SMR_genes_all_update_text_432422', 'Gene': 'RP11-67M1.1', 'topRSID': 'rs1551980', 'p_GWAS': 1.450181e-10, 'b_GWAS': -0.1218}]
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Q10.353
Q10
Are there any FOXJ1 SNPs that have a statistically significant association with Amyotrophic Lateral Sclerosis?
No, according to genome-wide analysis of Amyotrophic Lateral Sclerosis (Nicolas et al., 2018), there are no SNPs within FOXJ1 that are significantly associated with Amyotrophic Lateral Sclerosis.
SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full` WHERE Disease = 'ALS' AND Gene = 'FOXJ1' AND p_GWAS < 5e-8 ORDER BY p_GWAS LIMIT 100
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