uuid stringlengths 4 8 | template_uuid stringclasses 40
values | question stringlengths 13 193 | answer stringlengths 29 2.2k | benchmark_query stringlengths 133 622 | execution_results stringlengths 2 1.14M | query_type stringclasses 2
values | sql_category stringclasses 26
values | bio_category stringclasses 14
values |
|---|---|---|---|---|---|---|---|---|
Q40.1318 | Q40 | Are there any specific alleles within the gene PLPP3 associated with increased susceptibility to developing Amyotrophic Lateral Sclerosis, as determined by significant SMR analysis? | No, based on the Cortex samples tested, there are no alleles within the gene PLPP3 that are significantly associated with an increased susceptibility to developing Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'PLPP3' AND Disease = 'ALS' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1358 | Q40 | Are there any specific alleles within the gene OCM associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Cerebellum, Cortex and Whole Blood samples tested, there are no alleles within the gene OCM that are significantly associated with an increased susceptibility to developing Frontotemporal Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'OCM' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.414 | Q40 | Are there any specific alleles within the gene CTD-3105H18.4 associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Skeletal Muscle, Whole Brain and Cerebellum samples tested, there are no alleles within the gene CTD-3105H18.4 that are significantly associated with an increased susceptibility to developing Frontotemporal Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'CTD-3105H18.4' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1615 | Q40 | Are there any specific alleles within the gene CTC-429P9.3 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Prefrontal Cortex, Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain, Whole Blood, Whole Brain and Cerebellum samples tested, there are no alleles within the gene CTC-429P9.3 that are significantly associated with an increased susceptibility to developing Alzheime... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'CTC-429P9.3' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.687 | Q40 | Are there any specific alleles within the gene C11orf84 associated with increased susceptibility to developing Progressive supranuclear palsy, as determined by significant SMR analysis? | No, based on the Whole Brain and Whole Blood samples tested, there are no alleles within the gene C11orf84 that are significantly associated with an increased susceptibility to developing Progressive supranuclear palsy. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'C11orf84' AND Disease = 'PSP' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.621 | Q40 | Are there any specific alleles within the gene RP4-816N1.6 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain and Whole Blood samples tested, there are no alleles within the gene RP4-816N1.6 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP4-816N1.6' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.923 | Q40 | Are there any specific alleles within the gene ESPL1 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Cerebellum, Basal Ganglia, Whole Brain, Cortex, Caudate Basal Ganglia, Multi Ancestry Whole Brain, Hypothalamus, Liver, Putamen Basal Ganglia and Nucleus Accumbens Basal samples tested, there are no alleles within the gene ESPL1 that are significantly associated with an increased susceptibility to deve... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'ESPL1' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1199 | Q40 | Are there any specific alleles within the gene MOCS1 associated with increased susceptibility to developing Amyotrophic Lateral Sclerosis, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood, Cortex, Prefrontal Cortex, Skeletal Muscle and Multi Ancestry Whole Brain samples tested, there are no alleles within the gene MOCS1 that are significantly associated with an increased susceptibility to developing Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'MOCS1' AND Disease = 'ALS' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.839 | Q40 | Are there any specific alleles within the gene RP11-173P15.7 associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood and Skeletal Muscle samples tested, there are no alleles within the gene RP11-173P15.7 that are significantly associated with an increased susceptibility to developing Frontotemporal Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP11-173P15.7' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1771 | Q40 | Are there any specific alleles within the gene CHD1 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Prefrontal Cortex, Multi Ancestry Whole Brain and Whole Blood samples tested, there are no alleles within the gene CHD1 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'CHD1' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.953 | Q40 | Are there any specific alleles within the gene RETN associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Whole Brain and Whole Blood samples tested, there are no alleles within the gene RETN that are significantly associated with an increased susceptibility to developing Frontotemporal Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RETN' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.185 | Q40 | Are there any specific alleles within the gene WNT3 associated with increased susceptibility to developing Progressive supranuclear palsy, as determined by significant SMR analysis? | Yes, there are 4 alleles within the gene WNT3 that are significantly associated with an increased susceptibility to developing Progressive supranuclear palsy:
• rs2074404
• Whole Blood: Adjusted SMR multi-SNP P-value: 6.75e-20; b: 9.2244e+00
• rs8069437
• Cortex: Adjusted SMR multi-SNP P-value: 9.26e-18; b: 2.8... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'WNT3' AND Disease = 'PSP' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1579433', 'Gene': 'WNT3', 'Omic_tissue': 'Whole Blood', 'topSNP': 'rs2074404', 'A1': 'G', 'A2': 'T', 'Freq': 0.263804, 'p_SMR_multi': 6.747848e-20, 'Disease': 'PSP', 'b_SMR': 9.22443, 'p_HEIDI': 0.000130815}, {'UUID': 'NDD_SMR_genes_all_update_text_1154402', 'Gene': 'WNT3', 'Omi... | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1072 | Q40 | Are there any specific alleles within the gene PLEKHO1 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood, Multi Ancestry Whole Brain and Cerebellum samples tested, there are no alleles within the gene PLEKHO1 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'PLEKHO1' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.711 | Q40 | Are there any specific alleles within the gene GNGT1 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain and Whole Blood samples tested, there are no alleles within the gene GNGT1 that are significantly associated with an increased susceptibility to developing Parkinson's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'GNGT1' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.173 | Q40 | Are there any specific alleles within the gene MDFIC associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Whole Blood, Cortex, Skeletal Muscle and Multi Ancestry Whole Brain samples tested, there are no alleles within the gene MDFIC that are significantly associated with an increased susceptibility to developing Alzheimer's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'MDFIC' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.296 | Q40 | Are there any specific alleles within the gene KRT18P55 associated with increased susceptibility to developing Lewy Body Dementia, as determined by significant SMR analysis? | No, based on the Whole Blood samples tested, there are no alleles within the gene KRT18P55 that are significantly associated with an increased susceptibility to developing Lewy Body Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'KRT18P55' AND Disease = 'LBD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.554 | Q40 | Are there any specific alleles within the gene ZNF232 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | Yes, there is 1 allele within the gene ZNF232 that is significantly associated with an increased susceptibility to developing Alzheimer's Disease:
• rs2585266
• Whole Blood: Adjusted SMR multi-SNP P-value: 3.31e-07; b: 6.4019e-02 | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'ZNF232' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_589049', 'Gene': 'ZNF232', 'Omic_tissue': 'Whole Blood', 'topSNP': 'rs2585266', 'A1': 'T', 'A2': 'C', 'Freq': 0.0838446, 'p_SMR_multi': 3.314652e-07, 'Disease': 'AD', 'b_SMR': 0.0640194, 'p_HEIDI': 0.07594454}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.763 | Q40 | Are there any specific alleles within the gene BBS2 associated with increased susceptibility to developing Amyotrophic Lateral Sclerosis, as determined by significant SMR analysis? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain and Liver samples tested, there are no alleles within the gene BBS2 that are significantly associated with an increased susceptibility... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'BBS2' AND Disease = 'ALS' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.304 | Q40 | Are there any specific alleles within the gene MITD1 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Cerebellum, Cortex, Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain, Whole Blood, Whole Brain and Nucleus Accumbens Basal samples tested, there are no alleles within the gene MITD1 that are significantly associat... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'MITD1' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1878 | Q40 | Are there any specific alleles within the gene MKL1 associated with increased susceptibility to developing Amyotrophic Lateral Sclerosis, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood, Skeletal Muscle and Multi Ancestry Whole Brain samples tested, there are no alleles within the gene MKL1 that are significantly associated with an increased susceptibility to developing Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'MKL1' AND Disease = 'ALS' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1093 | Q40 | Are there any specific alleles within the gene RNF169 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Cerebellum, Basal Ganglia, Whole Brain, Whole Blood and Cortex samples tested, there are no alleles within the gene RNF169 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RNF169' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1747 | Q40 | Are there any specific alleles within the gene KNSTRN associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Cerebellum, Basal Ganglia, Spinalcord, Hippocampus, Whole Blood, Cortex, Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain, Substantia nigra, Hypothalamus, Liver, Anterior Cingulate Cortex BA24, Putamen Basal Gangl... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'KNSTRN' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1652 | Q40 | Are there any specific alleles within the gene C9orf72 associated with increased susceptibility to developing Amyotrophic Lateral Sclerosis, as determined by significant SMR analysis? | Yes, there are 7 alleles within the gene C9orf72 that are significantly associated with an increased susceptibility to developing Amyotrophic Lateral Sclerosis:
• rs774358
• Whole Blood: Adjusted SMR multi-SNP P-value: 6.69e-22; b: 1.3310e-01
• Whole Brain: Adjusted SMR multi-SNP P-value: 4.22e-14; b: 6.7751e-0... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'C9orf72' AND Disease = 'ALS' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1512421', 'Gene': 'C9orf72', 'Omic_tissue': 'Whole Blood', 'topSNP': 'rs774358', 'A1': 'T', 'A2': 'A', 'Freq': 0.280164, 'p_SMR_multi': 6.686547e-22, 'Disease': 'ALS', 'b_SMR': 0.133099, 'p_HEIDI': 2.803834e-11}, {'UUID': 'NDD_SMR_genes_all_update_text_1114010', 'Gene': 'C9orf72... | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.914 | Q40 | Are there any specific alleles within the gene ATP2C2 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex, Tibial Nerve, Multi Ancestry Whole Brain, Liver and Nucleus Accumbens Basal samples tested, there are no alleles within the gene ATP2C2 that are significantly associated with an increased susceptibility to developing Parkinson's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'ATP2C2' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1932 | Q40 | Are there any specific alleles within the gene RP5-1027O11.1 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Skeletal Muscle samples tested, there are no alleles within the gene RP5-1027O11.1 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP5-1027O11.1' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.275 | Q40 | Are there any specific alleles within the gene CAPN15 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex, Tibial Nerve and Multi Ancestry Whole Brain samples tested, there are no alleles within the gene CAPN15 that are significantly associated with an increased susceptibility to developing Parkinson's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'CAPN15' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1147 | Q40 | Are there any specific alleles within the gene TBX5 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood, Cortex and Prefrontal Cortex samples tested, there are no alleles within the gene TBX5 that are significantly associated with an increased susceptibility to developing Parkinson's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'TBX5' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1589 | Q40 | Are there any specific alleles within the gene RP11-680B3.2 associated with increased susceptibility to developing Amyotrophic Lateral Sclerosis, as determined by significant SMR analysis? | No, based on the Whole Brain and Whole Blood samples tested, there are no alleles within the gene RP11-680B3.2 that are significantly associated with an increased susceptibility to developing Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP11-680B3.2' AND Disease = 'ALS' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.700 | Q40 | Are there any specific alleles within the gene GACAT1 associated with increased susceptibility to developing Lewy Body Dementia, as determined by significant SMR analysis? | No, based on the Whole Blood samples tested, there are no alleles within the gene GACAT1 that are significantly associated with an increased susceptibility to developing Lewy Body Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'GACAT1' AND Disease = 'LBD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1765 | Q40 | Are there any specific alleles within the gene PPP3CC associated with increased susceptibility to developing Lewy Body Dementia, as determined by significant SMR analysis? | No, based on the Cerebellum, Whole Blood, Cortex, Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Caudate Basal Ganglia, Multi Ancestry Whole Brain, Hypothalamus, Anterior Cingulate Cortex BA24, Whole Brain and Nucleus Accumbens Basal samples tested, there are no alleles within the gene PPP3CC that are signif... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'PPP3CC' AND Disease = 'LBD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.488 | Q40 | Are there any specific alleles within the gene GDAP2 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood, Prefrontal Cortex and Multi Ancestry Whole Brain samples tested, there are no alleles within the gene GDAP2 that are significantly associated with an increased susceptibility to developing Parkinson's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'GDAP2' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.428 | Q40 | Are there any specific alleles within the gene C17orf51 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Whole Blood, Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain and Liver samples tested, there are no alleles within the gene C17orf51 that are significantly associated with an increased susceptibility to developing Parkinson's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'C17orf51' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.377 | Q40 | Are there any specific alleles within the gene AC138969.1 associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Cortex samples tested, there are no alleles within the gene AC138969.1 that are significantly associated with an increased susceptibility to developing Frontotemporal Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'AC138969.1' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1008 | Q40 | Are there any specific alleles within the gene RP11-264L1.4 associated with increased susceptibility to developing Progressive supranuclear palsy, as determined by significant SMR analysis? | No, based on the Whole Brain and Whole Blood samples tested, there are no alleles within the gene RP11-264L1.4 that are significantly associated with an increased susceptibility to developing Progressive supranuclear palsy. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP11-264L1.4' AND Disease = 'PSP' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1003 | Q40 | Are there any specific alleles within the gene RP11-122K13.12 associated with increased susceptibility to developing Lewy Body Dementia, as determined by significant SMR analysis? | No, based on the Tibial Nerve and Whole Blood samples tested, there are no alleles within the gene RP11-122K13.12 that are significantly associated with an increased susceptibility to developing Lewy Body Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP11-122K13.12' AND Disease = 'LBD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1940 | Q40 | Are there any specific alleles within the gene RP11-669E14.4 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | Yes, there are 2 alleles within the gene RP11-669E14.4 that are significantly associated with an increased susceptibility to developing Parkinson's Disease:
• rs17661027
• Liver: Adjusted SMR multi-SNP P-value: 2.52e-11; b: 4.0692e-01
• rs575074983
• Prefrontal Cortex: Adjusted SMR multi-SNP P-value: 6.39e-09; ... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP11-669E14.4' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1476425', 'Gene': 'RP11-669E14.4', 'Omic_tissue': 'Liver', 'topSNP': 'rs17661027', 'A1': 'A', 'A2': 'C', 'Freq': 0.236196, 'p_SMR_multi': 2.516234e-11, 'Disease': 'PD', 'b_SMR': 0.406924, 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1242275', 'Gene': 'RP11-669E14... | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.714 | Q40 | Are there any specific alleles within the gene RP11-867G2.8 associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Prefrontal Cortex samples tested, there are no alleles within the gene RP11-867G2.8 that are significantly associated with an increased susceptibility to developing Frontotemporal Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP11-867G2.8' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1335 | Q40 | Are there any specific alleles within the gene DENND1C associated with increased susceptibility to developing Amyotrophic Lateral Sclerosis, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood, Cortex, Frontal Cortex, Prefrontal Cortex and Multi Ancestry Whole Brain samples tested, there are no alleles within the gene DENND1C that are significantly associated with an increased susceptibility to developing Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'DENND1C' AND Disease = 'ALS' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1156 | Q40 | Are there any specific alleles within the gene RP11-384O8.1 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Prefrontal Cortex samples tested, there are no alleles within the gene RP11-384O8.1 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP11-384O8.1' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.338 | Q40 | Are there any specific alleles within the gene RP4-647C14.2 associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Tibial Nerve and Whole Blood samples tested, there are no alleles within the gene RP4-647C14.2 that are significantly associated with an increased susceptibility to developing Frontotemporal Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP4-647C14.2' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1343 | Q40 | Are there any specific alleles within the gene RP11-498P14.5 associated with increased susceptibility to developing Amyotrophic Lateral Sclerosis, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood, Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Cortex, Caudate Basal Ganglia, Tibial Nerve, Hippocampus, Hypothalamus, Anterior Cingulate Cortex BA24, Putamen Basal Ganglia, Amygdala, Cerebellum and Nucleus Accumbens Basal samples tested, there are no alleles within... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP11-498P14.5' AND Disease = 'ALS' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1593 | Q40 | Are there any specific alleles within the gene TLR9 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood, Multi Ancestry Whole Brain and Cerebellum samples tested, there are no alleles within the gene TLR9 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'TLR9' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1993 | Q40 | Are there any specific alleles within the gene RP11-307I14.4 associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Prefrontal Cortex samples tested, there are no alleles within the gene RP11-307I14.4 that are significantly associated with an increased susceptibility to developing Frontotemporal Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP11-307I14.4' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.598 | Q40 | Are there any specific alleles within the gene MGC57346 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | Yes, there are 2 alleles within the gene MGC57346 that are significantly associated with an increased susceptibility to developing Parkinson's Disease:
• rs62056790
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.12e-11; b: 5.0660e-01
• rs389217
• Whole Brain: Adjusted SMR multi-SNP P-value: 5.49e-08; b: 4.631... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'MGC57346' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_948857', 'Gene': 'MGC57346', 'Omic_tissue': 'Whole Blood', 'topSNP': 'rs62056790', 'A1': 'A', 'A2': 'G', 'Freq': 0.235174, 'p_SMR_multi': 1.122792e-11, 'Disease': 'PD', 'b_SMR': 0.506599, 'p_HEIDI': 9.975255e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_491084', 'Gene': 'MGC5734... | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.16 | Q40 | Are there any specific alleles within the gene ATP6V0E1 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain and Whole Blood samples tested, there are no alleles within the gene ATP6V0E1 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'ATP6V0E1' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1855 | Q40 | Are there any specific alleles within the gene CCDC173 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Cerebellum, Basal Ganglia, Whole Brain, Whole Blood, Cortex, Prefrontal Cortex, Caudate Basal Ganglia, Tibial Nerve, Hippocampus and Nucleus Accumbens Basal samples tested, there are no alleles within the gene CCDC173 that are significantly associated with an increased susceptibility to developing Park... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'CCDC173' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1634 | Q40 | Are there any specific alleles within the gene PLEKHM1 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | Yes, there are 5 alleles within the gene PLEKHM1 that are significantly associated with an increased susceptibility to developing Parkinson's Disease:
• rs62065453
• Cerebellum: Adjusted SMR multi-SNP P-value: 8.05e-13; b: 2.3506e-01
• rs1991556
• Cerebellum: Adjusted SMR multi-SNP P-value: 3.70e-12; b: 2.1967e... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'PLEKHM1' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_19645', 'Gene': 'PLEKHM1', 'Omic_tissue': 'Cerebellum', 'topSNP': '17:45496053:rs62065453:C_T', 'A1': 'C', 'A2': 'T', 'Freq': 0.763804, 'p_SMR_multi': 8.047881e-13, 'Disease': 'PD', 'b_SMR': 0.235057, 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1710340', 'Gene':... | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1686 | Q40 | Are there any specific alleles within the gene MUC8 associated with increased susceptibility to developing Lewy Body Dementia, as determined by significant SMR analysis? | No, based on the Whole Brain and Whole Blood samples tested, there are no alleles within the gene MUC8 that are significantly associated with an increased susceptibility to developing Lewy Body Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'MUC8' AND Disease = 'LBD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.600 | Q40 | Are there any specific alleles within the gene NCOR1 associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood, Cortex, Prefrontal Cortex and Multi Ancestry Whole Brain samples tested, there are no alleles within the gene NCOR1 that are significantly associated with an increased susceptibility to developing Frontotemporal Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'NCOR1' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.924 | Q40 | Are there any specific alleles within the gene CRACD associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Cerebellum and Cortex samples tested, there are no alleles within the gene CRACD that are significantly associated with an increased susceptibility to developing Parkinson's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'CRACD' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.471 | Q40 | Are there any specific alleles within the gene SLU7 associated with increased susceptibility to developing Progressive supranuclear palsy, as determined by significant SMR analysis? | No, based on the Cerebellum, Cortex, Skeletal Muscle and Whole Blood samples tested, there are no alleles within the gene SLU7 that are significantly associated with an increased susceptibility to developing Progressive supranuclear palsy. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'SLU7' AND Disease = 'PSP' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.202 | Q40 | Are there any specific alleles within the gene USP2-AS1 associated with increased susceptibility to developing Amyotrophic Lateral Sclerosis, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood and Skeletal Muscle samples tested, there are no alleles within the gene USP2-AS1 that are significantly associated with an increased susceptibility to developing Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'USP2-AS1' AND Disease = 'ALS' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1206 | Q40 | Are there any specific alleles within the gene ZNF668 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | Yes, there are 2 alleles within the gene ZNF668 that are significantly associated with an increased susceptibility to developing Parkinson's Disease:
• rs2303222
• Whole Blood: Adjusted SMR multi-SNP P-value: 4.08e-08; b: 2.4919e-01
• rs4889530
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 1.47e... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'ZNF668' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1563812', 'Gene': 'ZNF668', 'Omic_tissue': 'Whole Blood', 'topSNP': 'rs2303222', 'A1': 'C', 'A2': 'T', 'Freq': 0.397751, 'p_SMR_multi': 4.075299e-08, 'Disease': 'PD', 'b_SMR': 0.249193, 'p_HEIDI': 0.00010508}, {'UUID': 'NDD_SMR_genes_all_update_text_1435345', 'Gene': 'ZNF668', '... | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1056 | Q40 | Are there any specific alleles within the gene RPL39P associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | Yes, there is 1 allele within the gene RPL39P that is significantly associated with an increased susceptibility to developing Alzheimer's Disease:
• rs17462136
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.77e-09; b: 2.7220e-01 | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RPL39P' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1504671', 'Gene': 'RPL39P', 'Omic_tissue': 'Whole Blood', 'topSNP': 'rs17462136', 'A1': 'C', 'A2': 'G', 'Freq': 0.0879346, 'p_SMR_multi': 1.767814e-09, 'Disease': 'AD', 'b_SMR': 0.272201, 'p_HEIDI': 0.08237445}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1195 | Q40 | Are there any specific alleles within the gene ANXA11 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | Yes, there are 2 alleles within the gene ANXA11 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease:
• rs11591611
• Whole Blood: Adjusted SMR multi-SNP P-value: 3.59e-08; b: 1.1259e-01
• rs11201989
• Cortex: Adjusted SMR multi-SNP P-value: 2.32e-07; b: 5.6525e-02... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'ANXA11' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1497627', 'Gene': 'ANXA11', 'Omic_tissue': 'Whole Blood', 'topSNP': 'rs11591611', 'A1': 'A', 'A2': 'G', 'Freq': 0.233129, 'p_SMR_multi': 3.590815e-08, 'Disease': 'AD', 'b_SMR': 0.112594, 'p_HEIDI': 1.805917e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_1105559', 'Gene': 'ANXA11'... | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1300 | Q40 | Are there any specific alleles within the gene SERPINB2 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood, Cortex and Prefrontal Cortex samples tested, there are no alleles within the gene SERPINB2 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'SERPINB2' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1276 | Q40 | Are there any specific alleles within the gene RP11-838N2.5 associated with increased susceptibility to developing Lewy Body Dementia, as determined by significant SMR analysis? | No, based on the Whole Brain and Whole Blood samples tested, there are no alleles within the gene RP11-838N2.5 that are significantly associated with an increased susceptibility to developing Lewy Body Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP11-838N2.5' AND Disease = 'LBD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1814 | Q40 | Are there any specific alleles within the gene OR4L1 associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Whole Brain samples tested, there are no alleles within the gene OR4L1 that are significantly associated with an increased susceptibility to developing Frontotemporal Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'OR4L1' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1402 | Q40 | Are there any specific alleles within the gene LDLRAD4 associated with increased susceptibility to developing Lewy Body Dementia, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood, Cortex and Multi Ancestry Whole Brain samples tested, there are no alleles within the gene LDLRAD4 that are significantly associated with an increased susceptibility to developing Lewy Body Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'LDLRAD4' AND Disease = 'LBD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1807 | Q40 | Are there any specific alleles within the gene CTC-467M3.1 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain and Whole Blood samples tested, there are no alleles within the gene CTC-467M3.1 that are significantly associated with an increased susceptibility to developing Parkinson's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'CTC-467M3.1' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.661 | Q40 | Are there any specific alleles within the gene NIT1 associated with increased susceptibility to developing Amyotrophic Lateral Sclerosis, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood, Cortex, Prefrontal Cortex, Tibial Nerve, Multi Ancestry Whole Brain and Cerebellum samples tested, there are no alleles within the gene NIT1 that are significantly associated with an increased susceptibility to developing Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'NIT1' AND Disease = 'ALS' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.560 | Q40 | Are there any specific alleles within the gene SLC6A18 associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Whole Brain and Whole Blood samples tested, there are no alleles within the gene SLC6A18 that are significantly associated with an increased susceptibility to developing Frontotemporal Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'SLC6A18' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.44 | Q40 | Are there any specific alleles within the gene PDCL3 associated with increased susceptibility to developing Amyotrophic Lateral Sclerosis, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood, Prefrontal Cortex, Skeletal Muscle and Multi Ancestry Whole Brain samples tested, there are no alleles within the gene PDCL3 that are significantly associated with an increased susceptibility to developing Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'PDCL3' AND Disease = 'ALS' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.278 | Q40 | Are there any specific alleles within the gene MS4A6A associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | Yes, there are 2 alleles within the gene MS4A6A that are significantly associated with an increased susceptibility to developing Alzheimer's Disease:
• rs7935829
• Whole Blood: Adjusted SMR multi-SNP P-value: 4.25e-20; b: 1.9233e-01
• rs636147
• Whole Blood: Adjusted SMR multi-SNP P-value: 3.20e-10; b: 5.1352e-... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'MS4A6A' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1498262', 'Gene': 'MS4A6A', 'Omic_tissue': 'Whole Blood', 'topSNP': 'rs7935829', 'A1': 'G', 'A2': 'A', 'Freq': 0.404908, 'p_SMR_multi': 4.2520899999999996e-20, 'Disease': 'AD', 'b_SMR': 0.192333, 'p_HEIDI': 0.004241877}, {'UUID': 'NDD_SMR_genes_all_update_text_1650729', 'Gene': ... | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1096 | Q40 | Are there any specific alleles within the gene MFAP3 associated with increased susceptibility to developing Progressive supranuclear palsy, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood, Tibial Nerve and Multi Ancestry Whole Brain samples tested, there are no alleles within the gene MFAP3 that are significantly associated with an increased susceptibility to developing Progressive supranuclear palsy. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'MFAP3' AND Disease = 'PSP' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.104 | Q40 | Are there any specific alleles within the gene KIF3A associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood, Tibial Nerve, Skeletal Muscle and Multi Ancestry Whole Brain samples tested, there are no alleles within the gene KIF3A that are significantly associated with an increased susceptibility to developing Frontotemporal Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'KIF3A' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.856 | Q40 | Are there any specific alleles within the gene MOBP associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood, Cortex and Tibial Nerve samples tested, there are no alleles within the gene MOBP that are significantly associated with an increased susceptibility to developing Parkinson's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'MOBP' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.985 | Q40 | Are there any specific alleles within the gene RP11-541N10.3 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Prefrontal Cortex, Multi Ancestry Whole Brain, Whole Blood and Cerebellum samples tested, there are no alleles within the gene RP11-541N10.3 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP11-541N10.3' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.948 | Q40 | Are there any specific alleles within the gene AC007461.1 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Prefrontal Cortex samples tested, there are no alleles within the gene AC007461.1 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'AC007461.1' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.110 | Q40 | Are there any specific alleles within the gene ASCC2 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex, Cerebellar Hemisphere, Tibial Nerve, Skeletal Muscle, Hippocampus, Multi Ancestry Whole Brain and Nucleus Accumbens Basal samples tested, there are no alleles within the gene ASCC2 that are significantly associated with an increased susceptibility to develo... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'ASCC2' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1296 | Q40 | Are there any specific alleles within the gene AC005484.5 associated with increased susceptibility to developing Lewy Body Dementia, as determined by significant SMR analysis? | No, based on the Whole Blood, Prefrontal Cortex and Whole Brain samples tested, there are no alleles within the gene AC005484.5 that are significantly associated with an increased susceptibility to developing Lewy Body Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'AC005484.5' AND Disease = 'LBD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.503 | Q40 | Are there any specific alleles within the gene RP11-139K4.2 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Whole Blood samples tested, there are no alleles within the gene RP11-139K4.2 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP11-139K4.2' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1981 | Q40 | Are there any specific alleles within the gene ZNF546 associated with increased susceptibility to developing Lewy Body Dementia, as determined by significant SMR analysis? | No, based on the Whole Brain and Cortex samples tested, there are no alleles within the gene ZNF546 that are significantly associated with an increased susceptibility to developing Lewy Body Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'ZNF546' AND Disease = 'LBD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.869 | Q40 | Are there any specific alleles within the gene GPR18 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain and Whole Blood samples tested, there are no alleles within the gene GPR18 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'GPR18' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.748 | Q40 | Are there any specific alleles within the gene RP11-23P13.4 associated with increased susceptibility to developing Lewy Body Dementia, as determined by significant SMR analysis? | No, based on the Whole Brain samples tested, there are no alleles within the gene RP11-23P13.4 that are significantly associated with an increased susceptibility to developing Lewy Body Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP11-23P13.4' AND Disease = 'LBD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1015 | Q40 | Are there any specific alleles within the gene EEF1A1P6 associated with increased susceptibility to developing Lewy Body Dementia, as determined by significant SMR analysis? | No, based on the Whole Blood samples tested, there are no alleles within the gene EEF1A1P6 that are significantly associated with an increased susceptibility to developing Lewy Body Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'EEF1A1P6' AND Disease = 'LBD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1315 | Q40 | Are there any specific alleles within the gene ZKSCAN1 associated with increased susceptibility to developing Amyotrophic Lateral Sclerosis, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood, Cortex, Tibial Nerve, Skeletal Muscle and Multi Ancestry Whole Brain samples tested, there are no alleles within the gene ZKSCAN1 that are significantly associated with an increased susceptibility to developing Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'ZKSCAN1' AND Disease = 'ALS' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1297 | Q40 | Are there any specific alleles within the gene RP11-54C4.1 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Hippocampus, Substantia nigra, Hypothalamus, Liver, Anterior Cingulate Cortex BA24, Whole Blood, Putamen Basal Ganglia, Amygdala, Whole Brain, Cerebellum and Nucleus Accumbens Basal s... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP11-54C4.1' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.609 | Q40 | Are there any specific alleles within the gene DND1P1 associated with increased susceptibility to developing Progressive supranuclear palsy, as determined by significant SMR analysis? | Yes, there are 5 alleles within the gene DND1P1 that are significantly associated with an increased susceptibility to developing Progressive supranuclear palsy:
• rs169201
• Whole Blood: Adjusted SMR multi-SNP P-value: 9.42e-44; b: 1.0726e+00
• Whole Brain: Adjusted SMR multi-SNP P-value: 2.27e-22; b: 1.1369e+0... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'DND1P1' AND Disease = 'PSP' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1041717', 'Gene': 'DND1P1', 'Omic_tissue': 'Whole Blood', 'topSNP': 'rs169201', 'A1': 'G', 'A2': 'A', 'Freq': 0.219836, 'p_SMR_multi': 9.423973e-44, 'Disease': 'PSP', 'b_SMR': 1.07257, 'p_HEIDI': 8.563959e-12}, {'UUID': 'NDD_SMR_genes_all_update_text_1375925', 'Gene': 'DND1P1', ... | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1362 | Q40 | Are there any specific alleles within the gene DCAF16 associated with increased susceptibility to developing Progressive supranuclear palsy, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood, Tibial Nerve and Multi Ancestry Whole Brain samples tested, there are no alleles within the gene DCAF16 that are significantly associated with an increased susceptibility to developing Progressive supranuclear palsy. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'DCAF16' AND Disease = 'PSP' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.75 | Q40 | Are there any specific alleles within the gene SLC51B associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood and Cortex samples tested, there are no alleles within the gene SLC51B that are significantly associated with an increased susceptibility to developing Parkinson's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'SLC51B' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1082 | Q40 | Are there any specific alleles within the gene MARK4 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | Yes, there are 3 alleles within the gene MARK4 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease:
• rs12459074
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.62e-07; b: 1.6716e-01
• rs344806
• Whole Blood: Adjusted SMR multi-SNP P-value: 4.89e-07; b: 6.3181e-... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'MARK4' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_637454', 'Gene': 'MARK4', 'Omic_tissue': 'Whole Blood', 'topSNP': 'rs12459074', 'A1': 'C', 'A2': 'G', 'Freq': 0.256646, 'p_SMR_multi': 2.622366e-07, 'Disease': 'AD', 'b_SMR': 0.167158, 'p_HEIDI': 2.496883e-08}, {'UUID': 'NDD_SMR_genes_all_update_text_1503916', 'Gene': 'MARK4', '... | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1214 | Q40 | Are there any specific alleles within the gene LMAN1L associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Whole Brain and Cortex samples tested, there are no alleles within the gene LMAN1L that are significantly associated with an increased susceptibility to developing Frontotemporal Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'LMAN1L' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1167 | Q40 | Are there any specific alleles within the gene RP11-664H17.1 associated with increased susceptibility to developing Amyotrophic Lateral Sclerosis, as determined by significant SMR analysis? | No, based on the Whole Brain and Whole Blood samples tested, there are no alleles within the gene RP11-664H17.1 that are significantly associated with an increased susceptibility to developing Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP11-664H17.1' AND Disease = 'ALS' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.625 | Q40 | Are there any specific alleles within the gene ZNF580 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Whole Blood, Cortex, Prefrontal Cortex, Skeletal Muscle, Multi Ancestry Whole Brain and Whole Brain samples tested, there are no alleles within the gene ZNF580 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'ZNF580' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.487 | Q40 | Are there any specific alleles within the gene PHLDB3 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood, Cortex, Frontal Cortex, Prefrontal Cortex, Caudate Basal Ganglia, Skeletal Muscle, Hippocampus, Multi Ancestry Whole Brain, Hypothalamus, Liver, Anterior Cingulate Cortex BA24, Putamen Basal Ganglia and Nucleus Accumbens Basal samples tested, there are no alleles within the ge... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'PHLDB3' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1579 | Q40 | Are there any specific alleles within the gene OR2F1 associated with increased susceptibility to developing Lewy Body Dementia, as determined by significant SMR analysis? | No, based on the Cortex and Prefrontal Cortex samples tested, there are no alleles within the gene OR2F1 that are significantly associated with an increased susceptibility to developing Lewy Body Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'OR2F1' AND Disease = 'LBD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.512 | Q40 | Are there any specific alleles within the gene SMIM5 associated with increased susceptibility to developing Progressive supranuclear palsy, as determined by significant SMR analysis? | No, based on the Whole Blood samples tested, there are no alleles within the gene SMIM5 that are significantly associated with an increased susceptibility to developing Progressive supranuclear palsy. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'SMIM5' AND Disease = 'PSP' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.740 | Q40 | Are there any specific alleles within the gene TEN1 associated with increased susceptibility to developing Amyotrophic Lateral Sclerosis, as determined by significant SMR analysis? | No, based on the Cerebellum, Spinalcord, Whole Blood, Cortex, Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Hippocampus, Multi Ancestry Whole Brain, Substantia nigra, Hypothalamus, Liver, Anterior Cingulate Cortex BA24, Putamen Basal Ganglia, Amygdala, W... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'TEN1' AND Disease = 'ALS' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.762 | Q40 | Are there any specific alleles within the gene RP11-571L19.7 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain and Whole Blood samples tested, there are no alleles within the gene RP11-571L19.7 that are significantly associated with an increased susceptibility to developing Parkinson's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP11-571L19.7' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1990 | Q40 | Are there any specific alleles within the gene HS3ST2 associated with increased susceptibility to developing Amyotrophic Lateral Sclerosis, as determined by significant SMR analysis? | No, based on the Whole Brain and Whole Blood samples tested, there are no alleles within the gene HS3ST2 that are significantly associated with an increased susceptibility to developing Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'HS3ST2' AND Disease = 'ALS' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.784 | Q40 | Are there any specific alleles within the gene AC093627.11 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain and Whole Blood samples tested, there are no alleles within the gene AC093627.11 that are significantly associated with an increased susceptibility to developing Parkinson's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'AC093627.11' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1763 | Q40 | Are there any specific alleles within the gene AC096669.1 associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Whole Brain samples tested, there are no alleles within the gene AC096669.1 that are significantly associated with an increased susceptibility to developing Frontotemporal Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'AC096669.1' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.848 | Q40 | Are there any specific alleles within the gene PSRC1 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood, Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain, Substantia nigra, Liver and Cerebellum samples tested, there are no alleles within the gene PSRC1 that are significantly associated with an increased susceptibility to ... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'PSRC1' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.315 | Q40 | Are there any specific alleles within the gene GPC2 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | Yes, there are 3 alleles within the gene GPC2 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease:
• rs866500
• Whole Brain: Adjusted SMR multi-SNP P-value: 6.78e-09; b: 4.9427e-02
• rs3779045
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.22e-08; b: 1.6797e-01... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'GPC2' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_74045', 'Gene': 'GPC2', 'Omic_tissue': 'Whole Brain', 'topSNP': 'rs866500', 'A1': 'G', 'A2': 'A', 'Freq': 0.766871, 'p_SMR_multi': 6.77721e-09, 'Disease': 'AD', 'b_SMR': 0.0494275, 'p_HEIDI': 5.570468e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_585980', 'Gene': 'GPC2', 'Omic_t... | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.816 | Q40 | Are there any specific alleles within the gene PARG associated with increased susceptibility to developing Lewy Body Dementia, as determined by significant SMR analysis? | No, based on the Prefrontal Cortex, Multi Ancestry Whole Brain, Whole Blood and Whole Brain samples tested, there are no alleles within the gene PARG that are significantly associated with an increased susceptibility to developing Lewy Body Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'PARG' AND Disease = 'LBD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.411 | Q40 | Are there any specific alleles within the gene RP11-392E22.3 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain and Whole Blood samples tested, there are no alleles within the gene RP11-392E22.3 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP11-392E22.3' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.826 | Q40 | Are there any specific alleles within the gene NARFL associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood, Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Hippocampus, Multi Ancestry Whole Brain, Hypothalamus, Liver, Anterior Cingulate Cortex BA24, Putamen Basal Ganglia, Cerebellum and Nucleus Accumbens Basal s... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'NARFL' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1143 | Q40 | Are there any specific alleles within the gene CRHR1-IT1 associated with increased susceptibility to developing Progressive supranuclear palsy, as determined by significant SMR analysis? | Yes, there are 4 alleles within the gene CRHR1-IT1 that are significantly associated with an increased susceptibility to developing Progressive supranuclear palsy:
• rs12373139
• Tibial Nerve: Adjusted SMR multi-SNP P-value: 2.25e-33; b: 1.4444e+00
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 3... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'CRHR1-IT1' AND Disease = 'PSP' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1336288', 'Gene': 'CRHR1-IT1', 'Omic_tissue': 'Tibial Nerve', 'topSNP': 'rs12373139', 'A1': 'A', 'A2': 'G', 'Freq': 0.235174, 'p_SMR_multi': 2.2496390000000006e-33, 'Disease': 'PSP', 'b_SMR': 1.44441, 'p_HEIDI': 3.916149e-19}, {'UUID': 'NDD_SMR_genes_all_update_text_1444270', 'G... | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.313 | Q40 | Are there any specific alleles within the gene DPCR1 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | Yes, there is 1 allele within the gene DPCR1 that is significantly associated with an increased susceptibility to developing Alzheimer's Disease:
• rs2233980
• Whole Blood: Adjusted SMR multi-SNP P-value: 5.38e-08; b: 9.4577e-03 | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'DPCR1' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_620628', 'Gene': 'DPCR1', 'Omic_tissue': 'Whole Blood', 'topSNP': 'rs2233980', 'A1': 'A', 'A2': 'G', 'Freq': 0.0838446, 'p_SMR_multi': 5.375279e-08, 'Disease': 'AD', 'b_SMR': 0.00945771, 'p_HEIDI': 0.03561558}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
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