uuid stringlengths 4 8 | template_uuid stringclasses 40
values | question stringlengths 13 193 | answer stringlengths 29 2.2k | benchmark_query stringlengths 133 622 | execution_results stringlengths 2 1.14M | query_type stringclasses 2
values | sql_category stringclasses 26
values | bio_category stringclasses 14
values |
|---|---|---|---|---|---|---|---|---|
Q40.331 | Q40 | Are there any specific alleles within the gene RGS22 associated with increased susceptibility to developing Amyotrophic Lateral Sclerosis, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood, Cortex and Tibial Nerve samples tested, there are no alleles within the gene RGS22 that are significantly associated with an increased susceptibility to developing Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RGS22' AND Disease = 'ALS' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.448 | Q40 | Are there any specific alleles within the gene ZCWPW1 associated with increased susceptibility to developing Amyotrophic Lateral Sclerosis, as determined by significant SMR analysis? | No, based on the Basal Ganglia, Spinalcord, Whole Brain, Whole Blood, Cortex, Frontal Cortex, Prefrontal Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Hippocampus, Multi Ancestry Whole Brain, Substantia nigra, Hypothalamus, Anterior Cingulate Cortex BA24, Putamen Basal Ganglia, Amygdala and Nucleus Accu... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'ZCWPW1' AND Disease = 'ALS' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.766 | Q40 | Are there any specific alleles within the gene RP11-69G7.1 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Whole Blood samples tested, there are no alleles within the gene RP11-69G7.1 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP11-69G7.1' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1844 | Q40 | Are there any specific alleles within the gene FCER1G associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | Yes, there is 1 allele within the gene FCER1G that is significantly associated with an increased susceptibility to developing Alzheimer's Disease:
• rs4379692
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 2.89e-07; b: 1.6738e-01 | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'FCER1G' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1389452', 'Gene': 'FCER1G', 'Omic_tissue': 'Multi Ancestry Whole Brain', 'topSNP': 'rs4379692', 'A1': 'T', 'A2': 'C', 'Freq': 0.320041, 'p_SMR_multi': 2.894472e-07, 'Disease': 'AD', 'b_SMR': 0.167383, 'p_HEIDI': 0.005983408}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.913 | Q40 | Are there any specific alleles within the gene AP001597.1 associated with increased susceptibility to developing Progressive supranuclear palsy, as determined by significant SMR analysis? | No, based on the Whole Brain samples tested, there are no alleles within the gene AP001597.1 that are significantly associated with an increased susceptibility to developing Progressive supranuclear palsy. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'AP001597.1' AND Disease = 'PSP' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1141 | Q40 | Are there any specific alleles within the gene RP11-734K21.4 associated with increased susceptibility to developing Lewy Body Dementia, as determined by significant SMR analysis? | No, based on the Whole Brain and Whole Blood samples tested, there are no alleles within the gene RP11-734K21.4 that are significantly associated with an increased susceptibility to developing Lewy Body Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP11-734K21.4' AND Disease = 'LBD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.180 | Q40 | Are there any specific alleles within the gene CDS2 associated with increased susceptibility to developing Lewy Body Dementia, as determined by significant SMR analysis? | No, based on the Cerebellum, Basal Ganglia, Cortex, Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Caudate Basal Ganglia, Tibial Nerve, Hippocampus, Multi Ancestry Whole Brain, Substantia nigra, Anterior Cingulate Cortex BA24, Whole Blood, Putamen Basal Ganglia, Amygdala, Whole Brain and Nucleus Accumbens Ba... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'CDS2' AND Disease = 'LBD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.729 | Q40 | Are there any specific alleles within the gene RP11-706F1.2 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Prefrontal Cortex samples tested, there are no alleles within the gene RP11-706F1.2 that are significantly associated with an increased susceptibility to developing Parkinson's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP11-706F1.2' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1273 | Q40 | Are there any specific alleles within the gene MIR4513 associated with increased susceptibility to developing Lewy Body Dementia, as determined by significant SMR analysis? | No, based on the Whole Blood samples tested, there are no alleles within the gene MIR4513 that are significantly associated with an increased susceptibility to developing Lewy Body Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'MIR4513' AND Disease = 'LBD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.89 | Q40 | Are there any specific alleles within the gene BCL3 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | Yes, there is 1 allele within the gene BCL3 that is significantly associated with an increased susceptibility to developing Alzheimer's Disease:
• rs62117204
• Whole Brain: Adjusted SMR multi-SNP P-value: 2.18e-12; b: 2.9942e-01 | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'BCL3' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_122454', 'Gene': 'BCL3', 'Omic_tissue': 'Whole Brain', 'topSNP': 'rs62117204', 'A1': 'C', 'A2': 'T', 'Freq': 0.945808, 'p_SMR_multi': 2.17823e-12, 'Disease': 'AD', 'b_SMR': 0.299421, 'p_HEIDI': 3.038828e-06}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1410 | Q40 | Are there any specific alleles within the gene RP11-173D14.3 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Prefrontal Cortex samples tested, there are no alleles within the gene RP11-173D14.3 that are significantly associated with an increased susceptibility to developing Parkinson's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP11-173D14.3' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1900 | Q40 | Are there any specific alleles within the gene FAM190A associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | Yes, there is 1 allele within the gene FAM190A that is significantly associated with an increased susceptibility to developing Parkinson's Disease:
• rs1835524
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.66e-07; b: 1.2194e-01 | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'FAM190A' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_998616', 'Gene': 'FAM190A', 'Omic_tissue': 'Whole Blood', 'topSNP': 'rs1835524', 'A1': 'C', 'A2': 'T', 'Freq': 0.168712, 'p_SMR_multi': 2.663993e-07, 'Disease': 'PD', 'b_SMR': 0.121939, 'p_HEIDI': 0.0001542441}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.463 | Q40 | Are there any specific alleles within the gene ZNF213 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood, Cortex, Skeletal Muscle and Multi Ancestry Whole Brain samples tested, there are no alleles within the gene ZNF213 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'ZNF213' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1830 | Q40 | Are there any specific alleles within the gene PRSS36 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | Yes, there is 1 allele within the gene PRSS36 that is significantly associated with an increased susceptibility to developing Alzheimer's Disease:
• rs55667375
• Whole Brain: Adjusted SMR multi-SNP P-value: 6.46e-07; b: 9.2811e-02 | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'PRSS36' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_109538', 'Gene': 'PRSS36', 'Omic_tissue': 'Whole Brain', 'topSNP': 'rs55667375', 'A1': 'C', 'A2': 'T', 'Freq': 0.710634, 'p_SMR_multi': 6.457535e-07, 'Disease': 'AD', 'b_SMR': 0.0928108, 'p_HEIDI': 0.01582905}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.55 | Q40 | Are there any specific alleles within the gene STN1 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Cortex samples tested, there are no alleles within the gene STN1 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'STN1' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1503 | Q40 | Are there any specific alleles within the gene ZNF843 associated with increased susceptibility to developing Amyotrophic Lateral Sclerosis, as determined by significant SMR analysis? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex, Cerebellar Hemisphere, Tibial Nerve and Skeletal Muscle samples tested, there are no alleles within the gene ZNF843 that are significantly associated with an increased susceptibility to developing Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'ZNF843' AND Disease = 'ALS' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.650 | Q40 | Are there any specific alleles within the gene OR13C2 associated with increased susceptibility to developing Amyotrophic Lateral Sclerosis, as determined by significant SMR analysis? | No, based on the Cortex samples tested, there are no alleles within the gene OR13C2 that are significantly associated with an increased susceptibility to developing Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'OR13C2' AND Disease = 'ALS' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.684 | Q40 | Are there any specific alleles within the gene CYP21A2 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | Yes, there is 1 allele within the gene CYP21A2 that is significantly associated with an increased susceptibility to developing Alzheimer's Disease:
• rs433061
• Whole Blood: Adjusted SMR multi-SNP P-value: 9.25e-07; b: 1.9942e-02 | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'CYP21A2' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_621330', 'Gene': 'CYP21A2', 'Omic_tissue': 'Whole Blood', 'topSNP': 'rs433061', 'A1': 'A', 'A2': 'G', 'Freq': 0.0715746, 'p_SMR_multi': 9.251523e-07, 'Disease': 'AD', 'b_SMR': 0.0199423, 'p_HEIDI': 0.02788399}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.224 | Q40 | Are there any specific alleles within the gene TNRC6A associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Whole Brain and Whole Blood samples tested, there are no alleles within the gene TNRC6A that are significantly associated with an increased susceptibility to developing Frontotemporal Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'TNRC6A' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.116 | Q40 | Are there any specific alleles within the gene LSM14A associated with increased susceptibility to developing Amyotrophic Lateral Sclerosis, as determined by significant SMR analysis? | No, based on the Whole Blood samples tested, there are no alleles within the gene LSM14A that are significantly associated with an increased susceptibility to developing Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'LSM14A' AND Disease = 'ALS' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1552 | Q40 | Are there any specific alleles within the gene PDCD2L associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Whole Brain and Whole Blood samples tested, there are no alleles within the gene PDCD2L that are significantly associated with an increased susceptibility to developing Frontotemporal Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'PDCD2L' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1303 | Q40 | Are there any specific alleles within the gene MAPK8IP2 associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Cerebellum, Whole Brain, Whole Blood, Tibial Nerve and Multi Ancestry Whole Brain samples tested, there are no alleles within the gene MAPK8IP2 that are significantly associated with an increased susceptibility to developing Frontotemporal Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'MAPK8IP2' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.987 | Q40 | Are there any specific alleles within the gene RP11-50B3.2 associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Whole Blood and Skeletal Muscle samples tested, there are no alleles within the gene RP11-50B3.2 that are significantly associated with an increased susceptibility to developing Frontotemporal Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP11-50B3.2' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.177 | Q40 | Are there any specific alleles within the gene KANSL1 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | Yes, there are 5 alleles within the gene KANSL1 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease:
• rs2696569
• Whole Brain: Adjusted SMR multi-SNP P-value: 5.27e-08; b: 3.9240e-02
• rs12150087
• Whole Brain: Adjusted SMR multi-SNP P-value: 1.65e-07; b: 4.1158... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'KANSL1' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_115207', 'Gene': 'KANSL1', 'Omic_tissue': 'Whole Brain', 'topSNP': 'rs2696569', 'A1': 'C', 'A2': 'G', 'Freq': 0.238241, 'p_SMR_multi': 5.266316e-08, 'Disease': 'AD', 'b_SMR': 0.0392404, 'p_HEIDI': 0.01258408}, {'UUID': 'NDD_SMR_genes_all_update_text_115208', 'Gene': 'KANSL1', 'O... | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1650 | Q40 | Are there any specific alleles within the gene CALN1 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood, Cortex and Prefrontal Cortex samples tested, there are no alleles within the gene CALN1 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'CALN1' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.596 | Q40 | Are there any specific alleles within the gene RP11-258B16.1 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Whole Blood samples tested, there are no alleles within the gene RP11-258B16.1 that are significantly associated with an increased susceptibility to developing Parkinson's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP11-258B16.1' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1560 | Q40 | Are there any specific alleles within the gene YBX2 associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood, Cortex, Prefrontal Cortex, Multi Ancestry Whole Brain and Liver samples tested, there are no alleles within the gene YBX2 that are significantly associated with an increased susceptibility to developing Frontotemporal Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'YBX2' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.19 | Q40 | Are there any specific alleles within the gene NCOR1 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | Yes, there is 1 allele within the gene NCOR1 that is significantly associated with an increased susceptibility to developing Parkinson's Disease:
• rs178659
• Whole Brain: Adjusted SMR multi-SNP P-value: 1.21e-06; b: 1.1722e-01 | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'NCOR1' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_489615', 'Gene': 'NCOR1', 'Omic_tissue': 'Whole Brain', 'topSNP': 'rs178659', 'A1': 'C', 'A2': 'T', 'Freq': 0.473415, 'p_SMR_multi': 1.213845e-06, 'Disease': 'PD', 'b_SMR': 0.11722, 'p_HEIDI': -9999.0}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.429 | Q40 | Are there any specific alleles within the gene HMGB1L1 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain and Whole Blood samples tested, there are no alleles within the gene HMGB1L1 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'HMGB1L1' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1345 | Q40 | Are there any specific alleles within the gene NOTCH4 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | Yes, there are 2 alleles within the gene NOTCH4 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease:
• rs34562262
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.29e-07; b: 1.3920e-02
• rs9271663
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.19e-06; b: 6.6969... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'NOTCH4' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_621620', 'Gene': 'NOTCH4', 'Omic_tissue': 'Whole Blood', 'topSNP': 'rs34562262', 'A1': 'C', 'A2': 'G', 'Freq': 0.0337423, 'p_SMR_multi': 1.292283e-07, 'Disease': 'AD', 'b_SMR': 0.0139201, 'p_HEIDI': 0.003108897}, {'UUID': 'NDD_SMR_genes_all_update_text_621629', 'Gene': 'NOTCH4',... | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.289 | Q40 | Are there any specific alleles within the gene ARHGAP27 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | Yes, there are 14 alleles within the gene ARHGAP27 that are significantly associated with an increased susceptibility to developing Parkinson's Disease. Here are the top 10:
• rs35489312
• Whole Blood: Adjusted SMR multi-SNP P-value: 3.39e-15; b: 1.6945e-01
• rs62065376
• Whole Brain: Adjusted SMR multi-SNP P-v... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'ARHGAP27' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_948846', 'Gene': 'ARHGAP27', 'Omic_tissue': 'Whole Blood', 'topSNP': 'rs35489312', 'A1': 'C', 'A2': 'T', 'Freq': 0.190184, 'p_SMR_multi': 3.386602e-15, 'Disease': 'PD', 'b_SMR': 0.169454, 'p_HEIDI': 0.001263654}, {'UUID': 'NDD_SMR_genes_all_update_text_948845', 'Gene': 'ARHGAP27... | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1584 | Q40 | Are there any specific alleles within the gene RP5-921G16.1 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood, Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Cortex, Caudate Basal Ganglia, Hippocampus, Substantia nigra, Hypothalamus, Anterior Cingulate Cortex BA24, Putamen Basal Ganglia, Amygdala, Cerebellum and Nucleus Accumbens Basal samples tested, there are no alleles wi... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP5-921G16.1' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.434 | Q40 | Are there any specific alleles within the gene RP11-288L9.4 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Whole Blood samples tested, there are no alleles within the gene RP11-288L9.4 that are significantly associated with an increased susceptibility to developing Parkinson's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP11-288L9.4' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1640 | Q40 | Are there any specific alleles within the gene ACAD8 associated with increased susceptibility to developing Progressive supranuclear palsy, as determined by significant SMR analysis? | No, based on the Cerebellum and Whole Blood samples tested, there are no alleles within the gene ACAD8 that are significantly associated with an increased susceptibility to developing Progressive supranuclear palsy. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'ACAD8' AND Disease = 'PSP' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1245 | Q40 | Are there any specific alleles within the gene LAMC1 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Tibial Nerve, Skeletal Muscle and Multi Ancestry Whole Brain samples tested, there are no alleles within the gene LAMC1 that are significantly associated with an increased susceptibility to developing Parkinson's Di... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'LAMC1' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.676 | Q40 | Are there any specific alleles within the gene FAM38A associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain and Whole Blood samples tested, there are no alleles within the gene FAM38A that are significantly associated with an increased susceptibility to developing Parkinson's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'FAM38A' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.32 | Q40 | Are there any specific alleles within the gene ERLEC1 associated with increased susceptibility to developing Progressive supranuclear palsy, as determined by significant SMR analysis? | No, based on the Multi Ancestry Whole Brain and Whole Blood samples tested, there are no alleles within the gene ERLEC1 that are significantly associated with an increased susceptibility to developing Progressive supranuclear palsy. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'ERLEC1' AND Disease = 'PSP' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.934 | Q40 | Are there any specific alleles within the gene PDZD3 associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Whole Brain, Cortex, Cerebellar Hemisphere, Tibial Nerve and Whole Blood samples tested, there are no alleles within the gene PDZD3 that are significantly associated with an increased susceptibility to developing Frontotemporal Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'PDZD3' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.982 | Q40 | Are there any specific alleles within the gene RP11-195F19.5 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Skeletal Muscle samples tested, there are no alleles within the gene RP11-195F19.5 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP11-195F19.5' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.217 | Q40 | Are there any specific alleles within the gene TMF1 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Tibial Nerve, Multi Ancestry Whole Brain, Whole Blood and Whole Brain samples tested, there are no alleles within the gene TMF1 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'TMF1' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1130 | Q40 | Are there any specific alleles within the gene PIK3C2B associated with increased susceptibility to developing Amyotrophic Lateral Sclerosis, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood, Cortex and Multi Ancestry Whole Brain samples tested, there are no alleles within the gene PIK3C2B that are significantly associated with an increased susceptibility to developing Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'PIK3C2B' AND Disease = 'ALS' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.330 | Q40 | Are there any specific alleles within the gene AC006014.10 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Prefrontal Cortex samples tested, there are no alleles within the gene AC006014.10 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'AC006014.10' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.566 | Q40 | Are there any specific alleles within the gene GPCPD1 associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Whole Blood samples tested, there are no alleles within the gene GPCPD1 that are significantly associated with an increased susceptibility to developing Frontotemporal Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'GPCPD1' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1112 | Q40 | Are there any specific alleles within the gene ZNF296 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | Yes, there is 1 allele within the gene ZNF296 that is significantly associated with an increased susceptibility to developing Alzheimer's Disease:
• rs8100183
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 4.95e-09; b: 1.2019e-01 | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'ZNF296' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1397649', 'Gene': 'ZNF296', 'Omic_tissue': 'Multi Ancestry Whole Brain', 'topSNP': 'rs8100183', 'A1': 'T', 'A2': 'C', 'Freq': 0.185072, 'p_SMR_multi': 4.947535e-09, 'Disease': 'AD', 'b_SMR': 0.120194, 'p_HEIDI': 5.789577e-09}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.707 | Q40 | Are there any specific alleles within the gene TPP2 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood, Cortex, Prefrontal Cortex, Skeletal Muscle and Multi Ancestry Whole Brain samples tested, there are no alleles within the gene TPP2 that are significantly associated with an increased susceptibility to developing Parkinson's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'TPP2' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1979 | Q40 | Are there any specific alleles within the gene FBXL19 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | Yes, there is 1 allele within the gene FBXL19 that is significantly associated with an increased susceptibility to developing Parkinson's Disease:
• rs7200879
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.68e-06; b: 3.3047e-01 | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'FBXL19' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_974661', 'Gene': 'FBXL19', 'Omic_tissue': 'Whole Blood', 'topSNP': 'rs7200879', 'A1': 'G', 'A2': 'A', 'Freq': 0.249489, 'p_SMR_multi': 2.676196e-06, 'Disease': 'PD', 'b_SMR': 0.330471, 'p_HEIDI': 0.07563902}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1189 | Q40 | Are there any specific alleles within the gene FAM209B associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | Yes, there is 1 allele within the gene FAM209B that is significantly associated with an increased susceptibility to developing Alzheimer's Disease:
• rs56104586
• Whole Blood: Adjusted SMR multi-SNP P-value: 5.44e-07; b: 8.9144e-02 | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'FAM209B' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1504675', 'Gene': 'FAM209B', 'Omic_tissue': 'Whole Blood', 'topSNP': 'rs56104586', 'A1': 'G', 'A2': 'A', 'Freq': 0.349693, 'p_SMR_multi': 5.439246e-07, 'Disease': 'AD', 'b_SMR': 0.089144, 'p_HEIDI': 0.0001051177}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.345 | Q40 | Are there any specific alleles within the gene CD8B2 associated with increased susceptibility to developing Lewy Body Dementia, as determined by significant SMR analysis? | No, based on the Cerebellum and Cortex samples tested, there are no alleles within the gene CD8B2 that are significantly associated with an increased susceptibility to developing Lewy Body Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'CD8B2' AND Disease = 'LBD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.636 | Q40 | Are there any specific alleles within the gene POU5F1 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | Yes, there is 1 allele within the gene POU5F1 that is significantly associated with an increased susceptibility to developing Alzheimer's Disease:
• rs1265098
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.17e-06; b: 1.1694e-02 | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'POU5F1' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_620801', 'Gene': 'POU5F1', 'Omic_tissue': 'Whole Blood', 'topSNP': 'rs1265098', 'A1': 'C', 'A2': 'T', 'Freq': 0.275051, 'p_SMR_multi': 1.168562e-06, 'Disease': 'AD', 'b_SMR': 0.0116943, 'p_HEIDI': 0.01435111}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.150 | Q40 | Are there any specific alleles within the gene TMPRSS6 associated with increased susceptibility to developing Amyotrophic Lateral Sclerosis, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood and Nucleus Accumbens Basal samples tested, there are no alleles within the gene TMPRSS6 that are significantly associated with an increased susceptibility to developing Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'TMPRSS6' AND Disease = 'ALS' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1197 | Q40 | Are there any specific alleles within the gene IFI6 associated with increased susceptibility to developing Lewy Body Dementia, as determined by significant SMR analysis? | No, based on the Whole Blood and Multi Ancestry Whole Brain samples tested, there are no alleles within the gene IFI6 that are significantly associated with an increased susceptibility to developing Lewy Body Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'IFI6' AND Disease = 'LBD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.365 | Q40 | Are there any specific alleles within the gene RP11-332J15.2 associated with increased susceptibility to developing Lewy Body Dementia, as determined by significant SMR analysis? | No, based on the Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Cortex, Caudate Basal Ganglia, Putamen Basal Ganglia, Amygdala, Whole Brain, Cerebellum and Nucleus Accumbens Basal samples tested, there are no alleles within the gene RP11-332J15.2 that are significantly associated with an increased susceptibi... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP11-332J15.2' AND Disease = 'LBD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.86 | Q40 | Are there any specific alleles within the gene TGFB2 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain and Whole Blood samples tested, there are no alleles within the gene TGFB2 that are significantly associated with an increased susceptibility to developing Parkinson's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'TGFB2' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.49 | Q40 | Are there any specific alleles within the gene MAPT-AS1 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | Yes, there are 4 alleles within the gene MAPT-AS1 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease:
• rs1819040
• Prefrontal Cortex: Adjusted SMR multi-SNP P-value: 1.74e-07; b: 1.0117e-01
• rs112310745
• Whole Blood: Adjusted SMR multi-SNP P-value: 7.63e-07; ... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'MAPT-AS1' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1203009', 'Gene': 'MAPT-AS1', 'Omic_tissue': 'Prefrontal Cortex', 'topSNP': 'rs1819040', 'A1': 'A', 'A2': 'T', 'Freq': 0.237219, 'p_SMR_multi': 1.741788e-07, 'Disease': 'AD', 'b_SMR': 0.101165, 'p_HEIDI': 0.008558721}, {'UUID': 'NDD_SMR_genes_all_update_text_591182', 'Gene': 'MA... | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.474 | Q40 | Are there any specific alleles within the gene H2AFY2 associated with increased susceptibility to developing Lewy Body Dementia, as determined by significant SMR analysis? | No, based on the Whole Brain and Whole Blood samples tested, there are no alleles within the gene H2AFY2 that are significantly associated with an increased susceptibility to developing Lewy Body Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'H2AFY2' AND Disease = 'LBD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.158 | Q40 | Are there any specific alleles within the gene TMEM179 associated with increased susceptibility to developing Progressive supranuclear palsy, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood and Tibial Nerve samples tested, there are no alleles within the gene TMEM179 that are significantly associated with an increased susceptibility to developing Progressive supranuclear palsy. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'TMEM179' AND Disease = 'PSP' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.764 | Q40 | Are there any specific alleles within the gene NBPF10 associated with increased susceptibility to developing Amyotrophic Lateral Sclerosis, as determined by significant SMR analysis? | No, based on the Whole Blood and Whole Brain samples tested, there are no alleles within the gene NBPF10 that are significantly associated with an increased susceptibility to developing Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'NBPF10' AND Disease = 'ALS' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1027 | Q40 | Are there any specific alleles within the gene LL21NC02-1C16.1 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Frontal Cortex, Prefrontal Cortex, Cortex and Tibial Nerve samples tested, there are no alleles within the gene LL21NC02-1C16.1 that are significantly associated with an increased susceptibility to developing Parkinson's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'LL21NC02-1C16.1' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1200 | Q40 | Are there any specific alleles within the gene LA16c-381G6.1 associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Whole Brain and Whole Blood samples tested, there are no alleles within the gene LA16c-381G6.1 that are significantly associated with an increased susceptibility to developing Frontotemporal Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'LA16c-381G6.1' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1404 | Q40 | Are there any specific alleles within the gene ZSCAN22 associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Whole Blood and Multi Ancestry Whole Brain samples tested, there are no alleles within the gene ZSCAN22 that are significantly associated with an increased susceptibility to developing Frontotemporal Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'ZSCAN22' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1202 | Q40 | Are there any specific alleles within the gene SPATA32 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Whole Blood samples tested, there are no alleles within the gene SPATA32 that are significantly associated with an increased susceptibility to developing Parkinson's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'SPATA32' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1631 | Q40 | Are there any specific alleles within the gene TRAFD1 associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Whole Brain, Multi Ancestry Whole Brain and Whole Blood samples tested, there are no alleles within the gene TRAFD1 that are significantly associated with an increased susceptibility to developing Frontotemporal Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'TRAFD1' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.506 | Q40 | Are there any specific alleles within the gene SFTA2 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | Yes, there are 3 alleles within the gene SFTA2 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease:
• rs2233980
• Whole Blood: Adjusted SMR multi-SNP P-value: 4.14e-08; b: 9.9546e-03
• rs3132556
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.03e-07; b: 1.4139e-... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'SFTA2' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_620616', 'Gene': 'SFTA2', 'Omic_tissue': 'Whole Blood', 'topSNP': 'rs2233980', 'A1': 'A', 'A2': 'G', 'Freq': 0.0838446, 'p_SMR_multi': 4.13716e-08, 'Disease': 'AD', 'b_SMR': 0.00995464, 'p_HEIDI': 0.02253225}, {'UUID': 'NDD_SMR_genes_all_update_text_620617', 'Gene': 'SFTA2', 'Om... | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1670 | Q40 | Are there any specific alleles within the gene FAM135B associated with increased susceptibility to developing Lewy Body Dementia, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood and Tibial Nerve samples tested, there are no alleles within the gene FAM135B that are significantly associated with an increased susceptibility to developing Lewy Body Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'FAM135B' AND Disease = 'LBD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.182 | Q40 | Are there any specific alleles within the gene CTC-458G6.4 associated with increased susceptibility to developing Lewy Body Dementia, as determined by significant SMR analysis? | No, based on the Whole Blood samples tested, there are no alleles within the gene CTC-458G6.4 that are significantly associated with an increased susceptibility to developing Lewy Body Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'CTC-458G6.4' AND Disease = 'LBD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1419 | Q40 | Are there any specific alleles within the gene GBF1 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain and Whole Blood samples tested, there are no alleles within the gene GBF1 that are significantly associated with an increased susceptibility to developing Parkinson's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'GBF1' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1014 | Q40 | Are there any specific alleles within the gene RP11-665G4.1 associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Whole Brain and Whole Blood samples tested, there are no alleles within the gene RP11-665G4.1 that are significantly associated with an increased susceptibility to developing Frontotemporal Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP11-665G4.1' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1978 | Q40 | Are there any specific alleles within the gene PLXNB2 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood, Tibial Nerve, Skeletal Muscle and Multi Ancestry Whole Brain samples tested, there are no alleles within the gene PLXNB2 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'PLXNB2' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.864 | Q40 | Are there any specific alleles within the gene IFI35 associated with increased susceptibility to developing Progressive supranuclear palsy, as determined by significant SMR analysis? | No, based on the Whole Blood samples tested, there are no alleles within the gene IFI35 that are significantly associated with an increased susceptibility to developing Progressive supranuclear palsy. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'IFI35' AND Disease = 'PSP' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1620 | Q40 | Are there any specific alleles within the gene AC005355.1 associated with increased susceptibility to developing Amyotrophic Lateral Sclerosis, as determined by significant SMR analysis? | No, based on the Whole Brain and Whole Blood samples tested, there are no alleles within the gene AC005355.1 that are significantly associated with an increased susceptibility to developing Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'AC005355.1' AND Disease = 'ALS' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.534 | Q40 | Are there any specific alleles within the gene MYOC associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood and Skeletal Muscle samples tested, there are no alleles within the gene MYOC that are significantly associated with an increased susceptibility to developing Alzheimer's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'MYOC' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.350 | Q40 | Are there any specific alleles within the gene DPPA3 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Whole Blood samples tested, there are no alleles within the gene DPPA3 that are significantly associated with an increased susceptibility to developing Parkinson's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'DPPA3' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1389 | Q40 | Are there any specific alleles within the gene CD55 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | Yes, there are 3 alleles within the gene CD55 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease:
• rs891376
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.92e-09; b: 2.8747e-02
• rs7545125
• Whole Blood: Adjusted SMR multi-SNP P-value: 7.09e-09; b: 3.0404e-02... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'CD55' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1491150', 'Gene': 'CD55', 'Omic_tissue': 'Whole Blood', 'topSNP': 'rs891376', 'A1': 'T', 'A2': 'C', 'Freq': 0.256646, 'p_SMR_multi': 1.915107e-09, 'Disease': 'AD', 'b_SMR': 0.0287466, 'p_HEIDI': 4.65526e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_655837', 'Gene': 'CD55', 'Omic... | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1961 | Q40 | Are there any specific alleles within the gene SH3PXD2A associated with increased susceptibility to developing Progressive supranuclear palsy, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood and Skeletal Muscle samples tested, there are no alleles within the gene SH3PXD2A that are significantly associated with an increased susceptibility to developing Progressive supranuclear palsy. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'SH3PXD2A' AND Disease = 'PSP' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1301 | Q40 | Are there any specific alleles within the gene CTD-3157E16.1 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Frontal Cortex, Cortex, Tibial Nerve, Hypothalamus, Anterior Cingulate Cortex BA24, Putamen Basal Ganglia, Amygdala, Whole Brain and Nucleus Accumbens Basal samples tested, there are no alleles within the gene CTD-3157E16.1 that are significantly associated with an increased susceptibility to developin... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'CTD-3157E16.1' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1973 | Q40 | Are there any specific alleles within the gene LRRC20 associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood, Cortex, Prefrontal Cortex, Tibial Nerve, Skeletal Muscle and Multi Ancestry Whole Brain samples tested, there are no alleles within the gene LRRC20 that are significantly associated with an increased susceptibility to developing Frontotemporal Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'LRRC20' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1980 | Q40 | Are there any specific alleles within the gene NDUFAF6 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | Yes, there are 2 alleles within the gene NDUFAF6 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease:
• rs10098778
• Whole Brain: Adjusted SMR multi-SNP P-value: 7.12e-07; b: 3.8090e-02
• rs896853
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.77e-06; b: 1.0925... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'NDUFAF6' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_79375', 'Gene': 'NDUFAF6', 'Omic_tissue': 'Whole Brain', 'topSNP': 'rs10098778', 'A1': 'C', 'A2': 'T', 'Freq': 0.466258, 'p_SMR_multi': 7.122282e-07, 'Disease': 'AD', 'b_SMR': 0.0380897, 'p_HEIDI': 0.0001293247}, {'UUID': 'NDD_SMR_genes_all_update_text_616793', 'Gene': 'NDUFAF6'... | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.608 | Q40 | Are there any specific alleles within the gene RP11-677M14.2 associated with increased susceptibility to developing Progressive supranuclear palsy, as determined by significant SMR analysis? | No, based on the Whole Blood samples tested, there are no alleles within the gene RP11-677M14.2 that are significantly associated with an increased susceptibility to developing Progressive supranuclear palsy. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP11-677M14.2' AND Disease = 'PSP' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1050 | Q40 | Are there any specific alleles within the gene LINC00184 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Hippocampus, Hypothalamus, Anterior Cingulate Cortex BA24, Putamen Basal Ganglia, Whole Brain, Cerebellum and Nucleus Accumbens Basal samples tested, there are no alleles within the g... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'LINC00184' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.246 | Q40 | Are there any specific alleles within the gene CST3 associated with increased susceptibility to developing Lewy Body Dementia, as determined by significant SMR analysis? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex, Prefrontal Cortex, Tibial Nerve, Skeletal Muscle and Multi Ancestry Whole Brain samples tested, there are no alleles within the gene CST3 that are significantly associated with an increased susceptibility to developing Lewy Body Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'CST3' AND Disease = 'LBD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1681 | Q40 | Are there any specific alleles within the gene TOMM40 associated with increased susceptibility to developing Lewy Body Dementia, as determined by significant SMR analysis? | Yes, there is 1 allele within the gene TOMM40 that is significantly associated with an increased susceptibility to developing Lewy Body Dementia:
• rs7259620
• Whole Brain: Adjusted SMR multi-SNP P-value: 9.75e-08; b: 5.1138e-01 | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'TOMM40' AND Disease = 'LBD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1633475', 'Gene': 'TOMM40', 'Omic_tissue': 'Whole Brain', 'topSNP': 'rs7259620', 'A1': 'A', 'A2': 'G', 'Freq': 0.443763, 'p_SMR_multi': 9.749371e-08, 'Disease': 'LBD', 'b_SMR': 0.511382, 'p_HEIDI': 3.932821e-15}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1799 | Q40 | Are there any specific alleles within the gene FBXL13 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood and Cortex samples tested, there are no alleles within the gene FBXL13 that are significantly associated with an increased susceptibility to developing Parkinson's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'FBXL13' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1717 | Q40 | Are there any specific alleles within the gene C7orf73 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood, Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Hippocampus, Multi Ancestry Whole Brain, Liver, Anterior Cingulate Cortex BA24, Putamen Basal Ganglia, Amygdala, Cerebellum and Nucleus Accumbens Basal sampl... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'C7orf73' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.316 | Q40 | Are there any specific alleles within the gene TMEM44-AS1 associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood, Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Hippocampus, Multi Ancestry Whole Brain, Substantia nigra, Hypothalamus, Liver, Anterior Cingulate Cortex BA24, Putamen Basal Ganglia, Cerebellum and Nucleus... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'TMEM44-AS1' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.441 | Q40 | Are there any specific alleles within the gene GZMK associated with increased susceptibility to developing Amyotrophic Lateral Sclerosis, as determined by significant SMR analysis? | No, based on the Whole Blood samples tested, there are no alleles within the gene GZMK that are significantly associated with an increased susceptibility to developing Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'GZMK' AND Disease = 'ALS' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1899 | Q40 | Are there any specific alleles within the gene RAB29 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | Yes, there is 1 allele within the gene RAB29 that is significantly associated with an increased susceptibility to developing Parkinson's Disease:
• rs823118
• Cortex: Adjusted SMR multi-SNP P-value: 1.91e-06; b: 2.8958e-01 | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RAB29' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1142765', 'Gene': 'RAB29', 'Omic_tissue': 'Cortex', 'topSNP': '1:205754444:rs823118:C_T', 'A1': 'C', 'A2': 'T', 'Freq': 0.464213, 'p_SMR_multi': 1.914143e-06, 'Disease': 'PD', 'b_SMR': 0.289584, 'p_HEIDI': 0.004581236}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1637 | Q40 | Are there any specific alleles within the gene OR10G3 associated with increased susceptibility to developing Lewy Body Dementia, as determined by significant SMR analysis? | No, based on the Whole Brain samples tested, there are no alleles within the gene OR10G3 that are significantly associated with an increased susceptibility to developing Lewy Body Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'OR10G3' AND Disease = 'LBD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.312 | Q40 | Are there any specific alleles within the gene LINC00337 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain and Whole Blood samples tested, there are no alleles within the gene LINC00337 that are significantly associated with an increased susceptibility to developing Parkinson's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'LINC00337' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.436 | Q40 | Are there any specific alleles within the gene ZAN associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | Yes, there is 1 allele within the gene ZAN that is significantly associated with an increased susceptibility to developing Alzheimer's Disease:
• rs160602
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.14e-06; b: 2.5173e-02 | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'ZAN' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_586044', 'Gene': 'ZAN', 'Omic_tissue': 'Whole Blood', 'topSNP': 'rs160602', 'A1': 'T', 'A2': 'A', 'Freq': 0.462168, 'p_SMR_multi': 1.137107e-06, 'Disease': 'AD', 'b_SMR': 0.0251729, 'p_HEIDI': 0.05051785}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.667 | Q40 | Are there any specific alleles within the gene MAT1A associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | Yes, there are 2 alleles within the gene MAT1A that are significantly associated with an increased susceptibility to developing Alzheimer's Disease:
• rs1890578
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.08e-08; b: 7.3388e-02
• Whole Brain: Adjusted SMR multi-SNP P-value: 1.43e-06; b: 8.4956e-02
• rs10749... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'MAT1A' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_572621', 'Gene': 'MAT1A', 'Omic_tissue': 'Whole Blood', 'topSNP': 'rs1890578', 'A1': 'T', 'A2': 'C', 'Freq': 0.328221, 'p_SMR_multi': 2.078454e-08, 'Disease': 'AD', 'b_SMR': 0.0733884, 'p_HEIDI': 0.002468691}, {'UUID': 'NDD_SMR_genes_all_update_text_85765', 'Gene': 'MAT1A', 'Omi... | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.376 | Q40 | Are there any specific alleles within the gene TBX6 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | Yes, there is 1 allele within the gene TBX6 that is significantly associated with an increased susceptibility to developing Alzheimer's Disease:
• rs3809627
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 4.66e-07; b: 4.8477e-02 | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'TBX6' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1396163', 'Gene': 'TBX6', 'Omic_tissue': 'Multi Ancestry Whole Brain', 'topSNP': 'rs3809627', 'A1': 'A', 'A2': 'C', 'Freq': 0.415133, 'p_SMR_multi': 4.656974e-07, 'Disease': 'AD', 'b_SMR': 0.0484769, 'p_HEIDI': 1.912084e-07}, {'UUID': 'NDD_SMR_genes_all_update_text_577435', 'Gen... | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.572 | Q40 | Are there any specific alleles within the gene INO80E associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | Yes, there are 6 alleles within the gene INO80E that are significantly associated with an increased susceptibility to developing Alzheimer's Disease:
• rs9925915
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.00e-11; b: 1.6490e-01
• Cortex: Adjusted SMR multi-SNP P-value: 7.15e-08; b: 1.3221e-01
• rs10871451
... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'INO80E' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1501441', 'Gene': 'INO80E', 'Omic_tissue': 'Whole Blood', 'topSNP': 'rs9925915', 'A1': 'C', 'A2': 'G', 'Freq': 0.44274, 'p_SMR_multi': 1.99921e-11, 'Disease': 'AD', 'b_SMR': 0.1649, 'p_HEIDI': 0.03371315}, {'UUID': 'NDD_SMR_genes_all_update_text_1610394', 'Gene': 'INO80E', 'Omic... | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1226 | Q40 | Are there any specific alleles within the gene RP11-71G12.1 associated with increased susceptibility to developing Amyotrophic Lateral Sclerosis, as determined by significant SMR analysis? | No, based on the Whole Blood samples tested, there are no alleles within the gene RP11-71G12.1 that are significantly associated with an increased susceptibility to developing Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP11-71G12.1' AND Disease = 'ALS' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.184 | Q40 | Are there any specific alleles within the gene EEF2K associated with increased susceptibility to developing Lewy Body Dementia, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood, Cortex, Prefrontal Cortex, Tibial Nerve and Multi Ancestry Whole Brain samples tested, there are no alleles within the gene EEF2K that are significantly associated with an increased susceptibility to developing Lewy Body Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'EEF2K' AND Disease = 'LBD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1115 | Q40 | Are there any specific alleles within the gene AC012146.7 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | Yes, there is 1 allele within the gene AC012146.7 that is significantly associated with an increased susceptibility to developing Alzheimer's Disease:
• rs73976311
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 1.69e-07; b: 7.7590e-02 | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'AC012146.7' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1396457', 'Gene': 'AC012146.7', 'Omic_tissue': 'Multi Ancestry Whole Brain', 'topSNP': 'rs73976311', 'A1': 'G', 'A2': 'T', 'Freq': 0.113497, 'p_SMR_multi': 1.693054e-07, 'Disease': 'AD', 'b_SMR': 0.0775899, 'p_HEIDI': 5.131379e-06}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.628 | Q40 | Are there any specific alleles within the gene STXBP1 associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Whole Brain and Whole Blood samples tested, there are no alleles within the gene STXBP1 that are significantly associated with an increased susceptibility to developing Frontotemporal Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'STXBP1' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1910 | Q40 | Are there any specific alleles within the gene MYH10 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood, Cortex and Multi Ancestry Whole Brain samples tested, there are no alleles within the gene MYH10 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'MYH10' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1192 | Q40 | Are there any specific alleles within the gene OR7E22P associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Tibial Nerve samples tested, there are no alleles within the gene OR7E22P that are significantly associated with an increased susceptibility to developing Frontotemporal Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'OR7E22P' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.940 | Q40 | Are there any specific alleles within the gene APOC1 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | Yes, there are 2 alleles within the gene APOC1 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease:
• rs1064725
• Whole Blood: Adjusted SMR multi-SNP P-value: 7.25e-07; b: 6.5868e-01
• rs892101
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 1.57e-0... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'APOC1' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_637428', 'Gene': 'APOC1', 'Omic_tissue': 'Whole Blood', 'topSNP': 'rs1064725', 'A1': 'G', 'A2': 'T', 'Freq': 0.0521472, 'p_SMR_multi': 7.245738e-07, 'Disease': 'AD', 'b_SMR': 0.658681, 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1397647', 'Gene': 'APOC1', 'Omic_... | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1774 | Q40 | Are there any specific alleles within the gene AC004899.3 associated with increased susceptibility to developing Lewy Body Dementia, as determined by significant SMR analysis? | No, based on the Hippocampus samples tested, there are no alleles within the gene AC004899.3 that are significantly associated with an increased susceptibility to developing Lewy Body Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'AC004899.3' AND Disease = 'LBD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.