uuid stringlengths 4 8 | template_uuid stringclasses 40
values | question stringlengths 13 193 | answer stringlengths 29 2.2k | benchmark_query stringlengths 133 622 | execution_results stringlengths 2 1.14M | query_type stringclasses 2
values | sql_category stringclasses 26
values | bio_category stringclasses 14
values |
|---|---|---|---|---|---|---|---|---|
Q11.1011 | Q11 | Are there any JAKMIP3 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Cerebellum, Basal Ganglia, Spinalcord, Hippocampus, Whole Brain, Whole Blood, Cortex, Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain, Substantia nigra, Hypothalamus, Anterior Cingulate Cortex BA24, Putamen Basal Ganglia, Amygdala and Nucleus Accumbens Basal samples tested there are no SNPs within the gene JAKMIP3 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'JAKMIP3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1086 | Q11 | Are there any ADAT3 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the ADAT3 gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs754799
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.98e-07; HEIDI: 4.4567e-05 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'ADAT3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_634445', 'Gene': 'ADAT3', 'topRSID': 'rs754799', 'p_SMR_multi': 2.976108e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 4.456736e-05}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.844 | Q11 | Are there any RP11-137L10.6 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Tibial Nerve samples tested there are no SNPs within the gene RP11-137L10.6 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'RP11-137L10.6' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1792 | Q11 | Are there any LRRC37A17P SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the LRRC37A17P gene has 1 SNP that is statistically significant in Parkinson's Disease:
• rs4630591
• Prefrontal Cortex: Adjusted SMR multi-SNP P-value: 2.43e-06; HEIDI: 2.6625e-01 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'LRRC37A17P' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1242291', 'Gene': 'LRRC37A17P', 'topRSID': 'rs4630591', 'p_SMR_multi': 2.430773e-06, 'Omic_tissue': 'Prefrontal Cortex', 'p_HEIDI': 0.2662457}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.308 | Q11 | Are there any GUCY2D SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Blood and Cortex samples tested there are no SNPs within the gene GUCY2D that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'GUCY2D' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1380 | Q11 | Are there any ZNF646 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the ZNF646 gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs750952
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.55e-06; HEIDI: 4.5718e-04 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'ZNF646' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_577503', 'Gene': 'ZNF646', 'topRSID': 'rs750952', 'p_SMR_multi': 2.551509e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.0004571813}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1558 | Q11 | Are there any SPDYE2 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Cortex, Skeletal Muscle and Whole Blood samples tested there are no SNPs within the gene SPDYE2 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'SPDYE2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.317 | Q11 | Are there any MYC SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene MYC that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'MYC' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.152 | Q11 | Are there any WDFY4 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain and Nucleus Accumbens Basal samples tested there are no SNPs within the gene WDFY4 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'WDFY4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1158 | Q11 | Are there any SKA3 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex and Tibial Nerve samples tested there are no SNPs within the gene SKA3 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'SKA3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1223 | Q11 | Are there any RP11-184E9.1 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Prefrontal Cortex samples tested there are no SNPs within the gene RP11-184E9.1 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'RP11-184E9.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.580 | Q11 | Are there any PHF21A SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene PHF21A that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'PHF21A' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.51 | Q11 | Are there any RAB3GAP1 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene RAB3GAP1 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'RAB3GAP1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1553 | Q11 | Are there any PTP4A2 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene PTP4A2 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'PTP4A2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.733 | Q11 | Are there any INAFM2 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Cortex samples tested there are no SNPs within the gene INAFM2 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'INAFM2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.840 | Q11 | Are there any WWC2 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood and Skeletal Muscle samples tested there are no SNPs within the gene WWC2 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'WWC2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1392 | Q11 | Are there any COL19A1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Tibial Nerve and Cerebellum samples tested there are no SNPs within the gene COL19A1 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'COL19A1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1125 | Q11 | Are there any TGFB3 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene TGFB3 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'TGFB3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1176 | Q11 | Are there any DUSP15 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex, Skeletal Muscle and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene DUSP15 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'DUSP15' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.476 | Q11 | Are there any RP4-753D10.3 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cerebellum and Nucleus Accumbens Basal samples tested there are no SNPs within the gene RP4-753D10.3 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'RP4-753D10.3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.980 | Q11 | Are there any EDDM3B SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain samples tested there are no SNPs within the gene EDDM3B that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'EDDM3B' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.660 | Q11 | Are there any C12orf62 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene C12orf62 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'C12orf62' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.405 | Q11 | Are there any RP11-259G18.3 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the RP11-259G18.3 gene has 8 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs2732705
• Prefrontal Cortex: Adjusted SMR multi-SNP P-value: 3.73e-08; HEIDI: 3.9600e-03
• rs199439
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.07e-07; HEIDI: 2.2189e-01
• rs2696673
• Whole Blood: Adjusted SMR multi-SNP P-value: 5.05e-07; HEIDI: 5.7575e-01
• rs169201
• Skeletal Muscle: Adjusted SMR multi-SNP P-value: 8.43e-07; HEIDI: -9.9990e+03
• rs199456
• Tibial Nerve: Adjusted SMR multi-SNP P-value: 1.12e-06; HEIDI: -9.9990e+03
• Hippocampus: Adjusted SMR multi-SNP P-value: 2.65e-06; HEIDI: 9.6401e-01
• rs199533
• Cortex: Adjusted SMR multi-SNP P-value: 1.71e-06; HEIDI: 3.4653e-01
• Anterior Cingulate Cortex BA24: Adjusted SMR multi-SNP P-value: 2.10e-06; HEIDI: 8.7716e-01
• Whole Brain: Adjusted SMR multi-SNP P-value: 2.13e-06; HEIDI: 1.0895e-01
• rs9468
• Liver: Adjusted SMR multi-SNP P-value: 2.15e-06; HEIDI: 8.9609e-01
• rs55974014
• Nucleus Accumbens Basal: Adjusted SMR multi-SNP P-value: 2.36e-06; HEIDI: 7.6312e-01
• Caudate Basal Ganglia: Adjusted SMR multi-SNP P-value: 2.56e-06; HEIDI: 7.8226e-01
• Cerebellar Hemisphere: Adjusted SMR multi-SNP P-value: 2.83e-06; HEIDI: 7.6071e-01
• Hypothalamus: Adjusted SMR multi-SNP P-value: 2.92e-06; HEIDI: 9.3172e-01
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'RP11-259G18.3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1203014', 'Gene': 'RP11-259G18.3', 'topRSID': 'rs2732705', 'p_SMR_multi': 3.726622e-08, 'Omic_tissue': 'Prefrontal Cortex', 'p_HEIDI': 0.003959957}, {'UUID': 'NDD_SMR_genes_all_update_text_1502451', 'Gene': 'RP11-259G18.3', 'topRSID': 'rs199439', 'p_SMR_multi': 1.071189e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.2218925}, {'UUID': 'NDD_SMR_genes_all_update_text_1652501', 'Gene': 'RP11-259G18.3', 'topRSID': 'rs2696673', 'p_SMR_multi': 5.051548e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.5757453}, {'UUID': 'NDD_SMR_genes_all_update_text_1343156', 'Gene': 'RP11-259G18.3', 'topRSID': 'rs169201', 'p_SMR_multi': 8.431199e-07, 'Omic_tissue': 'Skeletal Muscle', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1291763', 'Gene': 'RP11-259G18.3', 'topRSID': 'rs199456', 'p_SMR_multi': 1.120949e-06, 'Omic_tissue': 'Tibial Nerve', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1247086', 'Gene': 'RP11-259G18.3', 'topRSID': 'rs199533', 'p_SMR_multi': 1.711899e-06, 'Omic_tissue': 'Cortex', 'p_HEIDI': 0.346528}, {'UUID': 'NDD_SMR_genes_all_update_text_1480161', 'Gene': 'RP11-259G18.3', 'topRSID': 'rs199533', 'p_SMR_multi': 2.101674e-06, 'Omic_tissue': 'Anterior Cingulate Cortex BA24', 'p_HEIDI': 0.8771589}, {'UUID': 'NDD_SMR_genes_all_update_text_1610868', 'Gene': 'RP11-259G18.3', 'topRSID': 'rs199533', 'p_SMR_multi': 2.129162e-06, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.1089491}, {'UUID': 'NDD_SMR_genes_all_update_text_1466648', 'Gene': 'RP11-259G18.3', 'topRSID': 'rs9468', 'p_SMR_multi': 2.153877e-06, 'Omic_tissue': 'Liver', 'p_HEIDI': 0.8960887}, {'UUID': 'NDD_SMR_genes_all_update_text_1717380', 'Gene': 'RP11-259G18.3', 'topRSID': 'rs55974014', 'p_SMR_multi': 2.358769e-06, 'Omic_tissue': 'Nucleus Accumbens Basal', 'p_HEIDI': 0.7631184}, {'UUID': 'NDD_SMR_genes_all_update_text_1268118', 'Gene': 'RP11-259G18.3', 'topRSID': 'rs55974014', 'p_SMR_multi': 2.561308e-06, 'Omic_tissue': 'Caudate Basal Ganglia', 'p_HEIDI': 0.7822575}, {'UUID': 'NDD_SMR_genes_all_update_text_1378571', 'Gene': 'RP11-259G18.3', 'topRSID': 'rs199456', 'p_SMR_multi': 2.650341e-06, 'Omic_tissue': 'Hippocampus', 'p_HEIDI': 0.9640104}, {'UUID': 'NDD_SMR_genes_all_update_text_1174600', 'Gene': 'RP11-259G18.3', 'topRSID': 'rs55974014', 'p_SMR_multi': 2.826981e-06, 'Omic_tissue': 'Cerebellar Hemisphere', 'p_HEIDI': 0.7607059}, {'UUID': 'NDD_SMR_genes_all_update_text_1454359', 'Gene': 'RP11-259G18.3', 'topRSID': 'rs55974014', 'p_SMR_multi': 2.924175e-06, 'Omic_tissue': 'Hypothalamus', 'p_HEIDI': 0.9317189}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.517 | Q11 | Are there any RP11-627K11.1 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene RP11-627K11.1 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'RP11-627K11.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.324 | Q11 | Are there any EML6 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex, Hippocampus and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene EML6 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'EML6' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.20 | Q11 | Are there any KLHL7-AS1 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Hippocampus, Substantia nigra, Hypothalamus, Liver, Anterior Cingulate Cortex BA24, Putamen Basal Ganglia, Amygdala, Cerebellum and Nucleus Accumbens Basal samples tested there are no SNPs within the gene KLHL7-AS1 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'KLHL7-AS1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.691 | Q11 | Are there any BNIP2 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cerebellar Hemisphere, Skeletal Muscle, Multi Ancestry Whole Brain and Cerebellum samples tested there are no SNPs within the gene BNIP2 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'BNIP2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.36 | Q11 | Are there any KIR3DL2 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene KIR3DL2 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'KIR3DL2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.910 | Q11 | Are there any TAP2 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the TAP2 gene has 4 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs241437
• Whole Blood: Adjusted SMR multi-SNP P-value: 8.32e-09; HEIDI: 3.6952e-03
• rs4148876
• Whole Blood: Adjusted SMR multi-SNP P-value: 9.94e-08; HEIDI: 1.7132e-04
• rs4148874
• Whole Blood: Adjusted SMR multi-SNP P-value: 5.53e-07; HEIDI: 5.7160e-03
• rs241439
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.10e-06; HEIDI: 4.3452e-03
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'TAP2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_621739', 'Gene': 'TAP2', 'topRSID': 'rs241437', 'p_SMR_multi': 8.321216e-09, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.003695236}, {'UUID': 'NDD_SMR_genes_all_update_text_1494776', 'Gene': 'TAP2', 'topRSID': 'rs4148876', 'p_SMR_multi': 9.936974e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.0001713229}, {'UUID': 'NDD_SMR_genes_all_update_text_621738', 'Gene': 'TAP2', 'topRSID': 'rs4148874', 'p_SMR_multi': 5.534853e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.005715957}, {'UUID': 'NDD_SMR_genes_all_update_text_621737', 'Gene': 'TAP2', 'topRSID': 'rs241439', 'p_SMR_multi': 2.095186e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.004345247}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.834 | Q11 | Are there any AP000462.3 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Cerebellar Hemisphere, Whole Brain and Cerebellum samples tested there are no SNPs within the gene AP000462.3 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'AP000462.3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1798 | Q11 | Are there any SLC25A45 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene SLC25A45 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'SLC25A45' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.413 | Q11 | Are there any ZFYVE26 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain, Skeletal Muscle and Whole Blood samples tested there are no SNPs within the gene ZFYVE26 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'ZFYVE26' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.928 | Q11 | Are there any TRIM34 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Cortex and Whole Blood samples tested there are no SNPs within the gene TRIM34 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'TRIM34' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.543 | Q11 | Are there any DNTT SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the DNTT gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs117699776
• Whole Blood: Adjusted SMR multi-SNP P-value: 9.39e-07; HEIDI: 9.9706e-01 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'DNTT' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1497703', 'Gene': 'DNTT', 'topRSID': 'rs117699776', 'p_SMR_multi': 9.393137e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.997057}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.765 | Q11 | Are there any ATAT1 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain samples tested there are no SNPs within the gene ATAT1 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'ATAT1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1905 | Q11 | Are there any FAM195B SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene FAM195B that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'FAM195B' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1071 | Q11 | Are there any NUP42 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the NUP42 gene has 2 SNPs that are statistically significant in Parkinson's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs2286272
• Cortex: Adjusted SMR multi-SNP P-value: 5.69e-08; HEIDI: 7.8191e-02
• rs10279691
• Cerebellum: Adjusted SMR multi-SNP P-value: 8.87e-08; HEIDI: 7.1990e-02
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'NUP42' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1146422', 'Gene': 'NUP42', 'topRSID': 'rs2286272', 'p_SMR_multi': 5.686312e-08, 'Omic_tissue': 'Cortex', 'p_HEIDI': 0.07819106}, {'UUID': 'NDD_SMR_genes_all_update_text_20282', 'Gene': 'NUP42', 'topRSID': 'rs10279691', 'p_SMR_multi': 8.866859e-08, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': 0.07198956}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1209 | Q11 | Are there any CRHR1 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the CRHR1 gene has 16 SNPs that are statistically significant in Parkinson's Disease. Here are the top 10 SNPs along with their adjusted SMR p-values:
• rs17689882
• Whole Blood: Adjusted SMR multi-SNP P-value: 8.63e-15; HEIDI: 7.3978e-05
• rs112746008
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.74e-13; HEIDI: 6.3243e-02
• rs113790915
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.26e-12; HEIDI: 9.6087e-05
• rs878888
• Whole Brain: Adjusted SMR multi-SNP P-value: 1.34e-12; HEIDI: 1.5840e-01
• rs567299266
• Prefrontal Cortex: Adjusted SMR multi-SNP P-value: 1.59e-12; HEIDI: 3.4935e-03
• rs2668632
• Cortex: Adjusted SMR multi-SNP P-value: 2.83e-12; HEIDI: 1.3856e-01
• rs453997
• Whole Brain: Adjusted SMR multi-SNP P-value: 9.55e-10; HEIDI: -9.9990e+03
• rs12944712
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.09e-09; HEIDI: 1.4367e-03
• rs241028
• Whole Brain: Adjusted SMR multi-SNP P-value: 5.91e-09; HEIDI: -9.9990e+03
• rs62054387
• Whole Brain: Adjusted SMR multi-SNP P-value: 7.59e-09; HEIDI: 1.7275e-01
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'CRHR1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_948861', 'Gene': 'CRHR1', 'topRSID': 'rs17689882', 'p_SMR_multi': 8.633399e-15, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 7.397796e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_948860', 'Gene': 'CRHR1', 'topRSID': 'rs112746008', 'p_SMR_multi': 2.741624e-13, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.06324297}, {'UUID': 'NDD_SMR_genes_all_update_text_948859', 'Gene': 'CRHR1', 'topRSID': 'rs113790915', 'p_SMR_multi': 1.255948e-12, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 9.60871e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_491090', 'Gene': 'CRHR1', 'topRSID': 'rs878888', 'p_SMR_multi': 1.344956e-12, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.1584008}, {'UUID': 'NDD_SMR_genes_all_update_text_1242271', 'Gene': 'CRHR1', 'topRSID': 'rs567299266', 'p_SMR_multi': 1.592654e-12, 'Omic_tissue': 'Prefrontal Cortex', 'p_HEIDI': 0.003493543}, {'UUID': 'NDD_SMR_genes_all_update_text_1147253', 'Gene': 'CRHR1', 'topRSID': 'rs2668632', 'p_SMR_multi': 2.828437e-12, 'Omic_tissue': 'Cortex', 'p_HEIDI': 0.1385602}, {'UUID': 'NDD_SMR_genes_all_update_text_948858', 'Gene': 'CRHR1', 'topRSID': 'rs113790915', 'p_SMR_multi': 5.272382e-12, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 2.167782e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_491087', 'Gene': 'CRHR1', 'topRSID': 'rs453997', 'p_SMR_multi': 9.548118e-10, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_948867', 'Gene': 'CRHR1', 'topRSID': 'rs12944712', 'p_SMR_multi': 1.085194e-09, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.001436736}, {'UUID': 'NDD_SMR_genes_all_update_text_491086', 'Gene': 'CRHR1', 'topRSID': 'rs241028', 'p_SMR_multi': 5.908091e-09, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_491088', 'Gene': 'CRHR1', 'topRSID': 'rs62054387', 'p_SMR_multi': 7.589803e-09, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.172753}, {'UUID': 'NDD_SMR_genes_all_update_text_1328931', 'Gene': 'CRHR1', 'topRSID': 'rs8070723', 'p_SMR_multi': 7.718008e-09, 'Omic_tissue': 'Tibial Nerve', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_491085', 'Gene': 'CRHR1', 'topRSID': 'rs3108317', 'p_SMR_multi': 1.034952e-08, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_948864', 'Gene': 'CRHR1', 'topRSID': 'rs62057073', 'p_SMR_multi': 2.486475e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.01253115}, {'UUID': 'NDD_SMR_genes_all_update_text_948866', 'Gene': 'CRHR1', 'topRSID': 'rs111273167', 'p_SMR_multi': 8.427721e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.0008187465}, {'UUID': 'NDD_SMR_genes_all_update_text_491089', 'Gene': 'CRHR1', 'topRSID': 'rs56303031', 'p_SMR_multi': 3.078916e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.9774144}, {'UUID': 'NDD_SMR_genes_all_update_text_1370543', 'Gene': 'CRHR1', 'topRSID': 'rs199439', 'p_SMR_multi': 1.996057e-06, 'Omic_tissue': 'Skeletal Muscle', 'p_HEIDI': 0.2494065}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.248 | Q11 | Are there any THOP1 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex, Skeletal Muscle, Multi Ancestry Whole Brain, Liver and Cerebellum samples tested there are no SNPs within the gene THOP1 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'THOP1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1431 | Q11 | Are there any LINC00484 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cerebellar Hemisphere, Prefrontal Cortex, Tibial Nerve, Skeletal Muscle and Cerebellum samples tested there are no SNPs within the gene LINC00484 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'LINC00484' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1137 | Q11 | Are there any Y_RNA SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the Y_RNA gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs114202986
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.22e-06; HEIDI: 1.7214e-02 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'Y_RNA' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1494722', 'Gene': 'Y_RNA', 'topRSID': 'rs114202986', 'p_SMR_multi': 2.22355e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.01721355}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.791 | Q11 | Are there any SCTR SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex and Tibial Nerve samples tested there are no SNPs within the gene SCTR that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'SCTR' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1744 | Q11 | Are there any MRE11A SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Hippocampus, Multi Ancestry Whole Brain, Substantia nigra, Hypothalamus, Liver, Anterior Cingulate Cortex BA24, Whole Blood, Putamen Basal Ganglia, Amygdala, Whole Brain, Cerebellum and Nucleus Accumbens Basal samples tested there are no SNPs within the gene MRE11A that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'MRE11A' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.495 | Q11 | Are there any RP11-538I12.2 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene RP11-538I12.2 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'RP11-538I12.2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.157 | Q11 | Are there any RBBP4 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene RBBP4 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'RBBP4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.970 | Q11 | Are there any LA16c-325D7.1 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene LA16c-325D7.1 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'LA16c-325D7.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.860 | Q11 | Are there any RP11-33B1.4 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene RP11-33B1.4 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'RP11-33B1.4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1325 | Q11 | Are there any RP11-156P1.3 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | Yes, the RP11-156P1.3 gene has 1 SNP that is statistically significant in Progressive supranuclear palsy:
• rs10491149
• Whole Blood: Adjusted SMR multi-SNP P-value: 8.77e-08; HEIDI: 7.8655e-03 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'RP11-156P1.3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1579436', 'Gene': 'RP11-156P1.3', 'topRSID': 'rs10491149', 'p_SMR_multi': 8.772626e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.007865466}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.632 | Q11 | Are there any PIGF SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex, Prefrontal Cortex, Caudate Basal Ganglia, Tibial Nerve and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene PIGF that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'PIGF' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.692 | Q11 | Are there any ETV1 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain, Prefrontal Cortex and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene ETV1 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'ETV1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1562 | Q11 | Are there any NKAIN4 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Cerebellum, Basal Ganglia, Whole Brain, Whole Blood, Cortex, Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Caudate Basal Ganglia, Tibial Nerve, Hippocampus, Hypothalamus, Anterior Cingulate Cortex BA24, Putamen Basal Ganglia, Amygdala and Nucleus Accumbens Basal samples tested there are no SNPs within the gene NKAIN4 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'NKAIN4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.575 | Q11 | Are there any GPR97 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene GPR97 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'GPR97' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1909 | Q11 | Are there any SNORD83 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene SNORD83 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'SNORD83' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.18 | Q11 | Are there any MT1IP SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene MT1IP that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'MT1IP' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.130 | Q11 | Are there any FPR1 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex, Tibial Nerve and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene FPR1 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'FPR1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1361 | Q11 | Are there any WI2-87327B8.1 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Skeletal Muscle and Whole Blood samples tested there are no SNPs within the gene WI2-87327B8.1 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'WI2-87327B8.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1291 | Q11 | Are there any PPP1R3B SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene PPP1R3B that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'PPP1R3B' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1969 | Q11 | Are there any CD2AP SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the CD2AP gene has 6 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs13193054
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.60e-09; HEIDI: 5.1958e-02
• rs6931478
• Whole Blood: Adjusted SMR multi-SNP P-value: 5.59e-09; HEIDI: 3.7628e-02
• rs7738044
• Whole Brain: Adjusted SMR multi-SNP P-value: 6.50e-08; HEIDI: 1.0480e-01
• rs1004173
• Whole Brain: Adjusted SMR multi-SNP P-value: 8.80e-08; HEIDI: 6.3690e-02
• rs13212790
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.45e-07; HEIDI: 9.3337e-02
• rs12200115
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 6.09e-07; HEIDI: 3.4946e-08
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'CD2AP' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_622985', 'Gene': 'CD2AP', 'topRSID': 'rs13193054', 'p_SMR_multi': 2.598285e-09, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.05195758}, {'UUID': 'NDD_SMR_genes_all_update_text_622988', 'Gene': 'CD2AP', 'topRSID': 'rs6931478', 'p_SMR_multi': 5.589146e-09, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.03762816}, {'UUID': 'NDD_SMR_genes_all_update_text_67374', 'Gene': 'CD2AP', 'topRSID': 'rs7738044', 'p_SMR_multi': 6.498931e-08, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.1048021}, {'UUID': 'NDD_SMR_genes_all_update_text_67371', 'Gene': 'CD2AP', 'topRSID': 'rs1004173', 'p_SMR_multi': 8.803264e-08, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.06368991}, {'UUID': 'NDD_SMR_genes_all_update_text_622986', 'Gene': 'CD2AP', 'topRSID': 'rs13212790', 'p_SMR_multi': 1.447096e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.09333707}, {'UUID': 'NDD_SMR_genes_all_update_text_1392018', 'Gene': 'CD2AP', 'topRSID': 'rs12200115', 'p_SMR_multi': 6.092703e-07, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'p_HEIDI': 3.494603e-08}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.935 | Q11 | Are there any AC008060.8 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cerebellar Hemisphere and Cerebellum samples tested there are no SNPs within the gene AC008060.8 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'AC008060.8' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.989 | Q11 | Are there any CCL3 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Cortex and Whole Blood samples tested there are no SNPs within the gene CCL3 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'CCL3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1965 | Q11 | Are there any AC005841.1 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene AC005841.1 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'AC005841.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.193 | Q11 | Are there any FAM115D SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the FAM115D gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs2949770
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.24e-06; HEIDI: 9.9320e-04 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'FAM115D' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1496074', 'Gene': 'FAM115D', 'topRSID': 'rs2949770', 'p_SMR_multi': 1.235843e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.0009931984}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1149 | Q11 | Are there any RELB SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the RELB gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs75654248
• Whole Blood: Adjusted SMR multi-SNP P-value: 3.19e-10; HEIDI: 5.5924e-04 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'RELB' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_637442', 'Gene': 'RELB', 'topRSID': 'rs75654248', 'p_SMR_multi': 3.188959e-10, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.0005592422}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1001 | Q11 | Are there any ADAMTSL2 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Blood, Cortex, Prefrontal Cortex, Tibial Nerve, Multi Ancestry Whole Brain and Whole Brain samples tested there are no SNPs within the gene ADAMTSL2 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'ADAMTSL2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1956 | Q11 | Are there any RP4-758J18.13 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain and Whole Blood samples tested there are no SNPs within the gene RP4-758J18.13 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'RP4-758J18.13' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1657 | Q11 | Are there any POLR3A SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain, Prefrontal Cortex, Skeletal Muscle and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene POLR3A that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'POLR3A' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.613 | Q11 | Are there any PELI1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene PELI1 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'PELI1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.183 | Q11 | Are there any P2RX3 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex and Liver samples tested there are no SNPs within the gene P2RX3 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'P2RX3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.305 | Q11 | Are there any RP1-244F24.1 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Tibial Nerve samples tested there are no SNPs within the gene RP1-244F24.1 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'RP1-244F24.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.502 | Q11 | Are there any RP11-702H23.6 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain samples tested there are no SNPs within the gene RP11-702H23.6 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'RP11-702H23.6' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1696 | Q11 | Are there any C15orf38-AP3S2 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood and Prefrontal Cortex samples tested there are no SNPs within the gene C15orf38-AP3S2 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'C15orf38-AP3S2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1721 | Q11 | Are there any VEGFC SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene VEGFC that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'VEGFC' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1662 | Q11 | Are there any NAT10 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain, Cortex, Frontal Cortex, Prefrontal Cortex, Multi Ancestry Whole Brain, Whole Blood and Cerebellum samples tested there are no SNPs within the gene NAT10 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'NAT10' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1639 | Q11 | Are there any RP11-706F1.2 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Prefrontal Cortex samples tested there are no SNPs within the gene RP11-706F1.2 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'RP11-706F1.2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.523 | Q11 | Are there any C14orf1 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain samples tested there are no SNPs within the gene C14orf1 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'C14orf1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1985 | Q11 | Are there any CCDC23 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Hippocampus, Multi Ancestry Whole Brain, Substantia nigra, Hypothalamus, Liver, Anterior Cingulate Cortex BA24, Putamen Basal Ganglia, Amygdala, Cerebellum and Nucleus Accumbens Basal samples tested there are no SNPs within the gene CCDC23 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'CCDC23' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1078 | Q11 | Are there any ITGB4 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex, Prefrontal Cortex, Tibial Nerve and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene ITGB4 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'ITGB4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.482 | Q11 | Are there any CPVL SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex, Frontal Cortex, Prefrontal Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Hippocampus, Multi Ancestry Whole Brain and Substantia nigra samples tested there are no SNPs within the gene CPVL that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'CPVL' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.160 | Q11 | Are there any ORMDL1 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex, Frontal Cortex, Cerebellar Hemisphere, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Hippocampus, Multi Ancestry Whole Brain, Substantia nigra, Hypothalamus, Liver, Anterior Cingulate Cortex BA24, Putamen Basal Ganglia, Amygdala and Nucleus Accumbens Basal samples tested there are no SNPs within the gene ORMDL1 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'ORMDL1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1253 | Q11 | Are there any RN7SKP70 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Tibial Nerve samples tested there are no SNPs within the gene RN7SKP70 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'RN7SKP70' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1205 | Q11 | Are there any KXD1 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Cortex, Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain, Whole Blood and Whole Brain samples tested there are no SNPs within the gene KXD1 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'KXD1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.17 | Q11 | Are there any GPCPD1 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene GPCPD1 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'GPCPD1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1550 | Q11 | Are there any INPP5D SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the INPP5D gene has 3 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs62192877
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.28e-14; HEIDI: 2.0808e-02
• rs10933431
• Whole Blood: Adjusted SMR multi-SNP P-value: 5.83e-13; HEIDI: 3.1253e-01
• rs6715767
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.38e-07; HEIDI: 3.3362e-01
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'INPP5D' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1492359', 'Gene': 'INPP5D', 'topRSID': 'rs62192877', 'p_SMR_multi': 1.280101e-14, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.020808}, {'UUID': 'NDD_SMR_genes_all_update_text_633025', 'Gene': 'INPP5D', 'topRSID': 'rs10933431', 'p_SMR_multi': 5.825275e-13, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.312526}, {'UUID': 'NDD_SMR_genes_all_update_text_1648149', 'Gene': 'INPP5D', 'topRSID': 'rs6715767', 'p_SMR_multi': 1.380763e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.3336205}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1081 | Q11 | Are there any RP11-429B14.1 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene RP11-429B14.1 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'RP11-429B14.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1972 | Q11 | Are there any FAM180B SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the FAM180B gene has 2 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs11039308
• Cortex: Adjusted SMR multi-SNP P-value: 3.65e-07; HEIDI: 5.2947e-06
• rs11039307
• Cerebellum: Adjusted SMR multi-SNP P-value: 2.64e-06; HEIDI: 1.0866e-04
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'FAM180B' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1112428', 'Gene': 'FAM180B', 'topRSID': 'rs11039308', 'p_SMR_multi': 3.649495e-07, 'Omic_tissue': 'Cortex', 'p_HEIDI': 5.294735e-06}, {'UUID': 'NDD_SMR_genes_all_update_text_1529', 'Gene': 'FAM180B', 'topRSID': 'rs11039307', 'p_SMR_multi': 2.636371e-06, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': 0.0001086569}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.552 | Q11 | Are there any BFSP2 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene BFSP2 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'BFSP2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1554 | Q11 | Are there any EIF4G3 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain, Skeletal Muscle, Multi Ancestry Whole Brain and Whole Blood samples tested there are no SNPs within the gene EIF4G3 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'EIF4G3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.665 | Q11 | Are there any NCAM1 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Tibial Nerve, Skeletal Muscle and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene NCAM1 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'NCAM1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1626 | Q11 | Are there any FNBP4 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the FNBP4 gene has 2 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs11039337
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.09e-07; HEIDI: 3.3332e-04
• rs12807014
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.16e-06; HEIDI: 3.2125e-02
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'FNBP4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1498222', 'Gene': 'FNBP4', 'topRSID': 'rs11039337', 'p_SMR_multi': 2.085072e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.0003333185}, {'UUID': 'NDD_SMR_genes_all_update_text_608507', 'Gene': 'FNBP4', 'topRSID': 'rs12807014', 'p_SMR_multi': 1.162814e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.03212485}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1028 | Q11 | Are there any RP13-98N21.2 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Brain samples tested there are no SNPs within the gene RP13-98N21.2 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'RP13-98N21.2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1994 | Q11 | Are there any RP11-440G5.2 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Tibial Nerve samples tested there are no SNPs within the gene RP11-440G5.2 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'RP11-440G5.2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1519 | Q11 | Are there any TOB2P1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the TOB2P1 gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs1736890
• Whole Blood: Adjusted SMR multi-SNP P-value: 6.89e-07; HEIDI: 2.8982e-01 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'TOB2P1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_619608', 'Gene': 'TOB2P1', 'topRSID': 'rs1736890', 'p_SMR_multi': 6.886801e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.2898161}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.968 | Q11 | Are there any RP11-521O16.2 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the RP11-521O16.2 gene has 2 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs77279236
• Prefrontal Cortex: Adjusted SMR multi-SNP P-value: 7.65e-07; HEIDI: 2.3597e-01
• rs2404175
• Whole Brain: Adjusted SMR multi-SNP P-value: 2.63e-06; HEIDI: 4.8245e-06
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'RP11-521O16.2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1196032', 'Gene': 'RP11-521O16.2', 'topRSID': 'rs77279236', 'p_SMR_multi': 7.651473e-07, 'Omic_tissue': 'Prefrontal Cortex', 'p_HEIDI': 0.2359738}, {'UUID': 'NDD_SMR_genes_all_update_text_46329', 'Gene': 'RP11-521O16.2', 'topRSID': 'rs2404175', 'p_SMR_multi': 2.626947e-06, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 4.824502e-06}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1883 | Q11 | Are there any ZYX SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the ZYX gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs11772895
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.13e-08; HEIDI: 2.0754e-07 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'ZYX' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1496070', 'Gene': 'ZYX', 'topRSID': 'rs11772895', 'p_SMR_multi': 2.126153e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 2.075432e-07}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.287 | Q11 | Are there any HIPK2 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene HIPK2 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'HIPK2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q12.589 | Q12 | What other names are there for the drug Trimeprazine Tartrate? | Some additional names for Trimeprazine Tartrate are Panectyl, Vallergan, Trimeprazine tartrate, NSC-757358, Repeltin, Temaril, Trimeprazine hemitartrate, Methylpromazine tartrate, NSC-17475, Alimemazine tartrate, Theralene, Alimemazine hemitartrate, and Vallergan fte. | SELECT DISTINCT UUID, drugName, tradeNames_string, drugSynonyms_string
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE (LOWER(drugName) LIKE "%trimeprazine tartrate%" OR LOWER(tradeNames_string) LIKE "%trimeprazine tartrate%" OR LOWER(drugSynonyms_string) LIKE "%trimeprazine tartrate%")
LIMIT 100 | [{'UUID': 'DrugGeneTargets_v2_3705', 'drugName': 'Trimeprazine Tartrate', 'tradeNames_string': 'Temaril, Trimeprazine tartrate, Vallergan, Vallergan fte', 'drugSynonyms_string': 'Alimemazine hemitartrate, Alimemazine tartrate, Methylpromazine tartrate, NSC-17475, NSC-757358, Panectyl, Repeltin, Theralene, Trimeprazine hemitartrate, Trimeprazine tartrate'}] | general | Distinct, Similarity Search | Metadata |
Q12.1868 | Q12 | What other names are there for the drug Msx-122? | The drug Msx-122 has one aditional name: Msx 122. | SELECT DISTINCT UUID, drugName, tradeNames_string, drugSynonyms_string
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE (LOWER(drugName) LIKE "%msx-122%" OR LOWER(tradeNames_string) LIKE "%msx-122%" OR LOWER(drugSynonyms_string) LIKE "%msx-122%")
LIMIT 100 | [{'UUID': 'DrugGeneTargets_v2_1123', 'drugName': 'Msx-122', 'tradeNames_string': '', 'drugSynonyms_string': 'Msx 122, Msx-122'}] | general | Distinct, Similarity Search | Metadata |
Q12.1061 | Q12 | What other names are there for the drug Trazpiroben? | Some additional names for Trazpiroben are TAK906, TAK-906, and Tak-906. | SELECT DISTINCT UUID, drugName, tradeNames_string, drugSynonyms_string
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE (LOWER(drugName) LIKE "%trazpiroben%" OR LOWER(tradeNames_string) LIKE "%trazpiroben%" OR LOWER(drugSynonyms_string) LIKE "%trazpiroben%")
LIMIT 100 | [{'UUID': 'DrugGeneTargets_v2_2839', 'drugName': 'Trazpiroben', 'tradeNames_string': '', 'drugSynonyms_string': 'TAK-906, TAK906, Tak-906, Trazpiroben'}, {'UUID': 'DrugGeneTargets_v2_2840', 'drugName': 'Trazpiroben', 'tradeNames_string': '', 'drugSynonyms_string': 'TAK-906, TAK906, Tak-906, Trazpiroben'}] | general | Distinct, Similarity Search | Metadata |
Q12.1084 | Q12 | What other names are there for the drug Macimorelin Acetate? | Some additional names for Macimorelin Acetate are Macimorelin acetate, Macrilen, EP 1572, ARD 07, and D-87575. | SELECT DISTINCT UUID, drugName, tradeNames_string, drugSynonyms_string
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE (LOWER(drugName) LIKE "%macimorelin acetate%" OR LOWER(tradeNames_string) LIKE "%macimorelin acetate%" OR LOWER(drugSynonyms_string) LIKE "%macimorelin acetate%")
LIMIT 100 | [{'UUID': 'DrugGeneTargets_v2_942', 'drugName': 'Macimorelin Acetate', 'tradeNames_string': 'Macrilen', 'drugSynonyms_string': 'ARD 07, D-87575, EP 1572, Macimorelin acetate'}] | general | Distinct, Similarity Search | Metadata |
Q12.925 | Q12 | What other names are there for the drug Aripiprazole? | Some additional names for Aripiprazole are Abilify, Abilify maintena kit, Abilify maintena, NSC-759266, OPC-14597, Aripiprex, Abilify mycite, OPC-31, and Abilify mycite kit. | SELECT DISTINCT UUID, drugName, tradeNames_string, drugSynonyms_string
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE (LOWER(drugName) LIKE "%aripiprazole%" OR LOWER(tradeNames_string) LIKE "%aripiprazole%" OR LOWER(drugSynonyms_string) LIKE "%aripiprazole%")
LIMIT 100 | [{'UUID': 'DrugGeneTargets_v2_2619', 'drugName': 'Aripiprazole', 'tradeNames_string': 'Abilify, Abilify maintena, Abilify maintena kit, Abilify mycite kit, Aripiprazole', 'drugSynonyms_string': 'Abilify mycite, Aripiprazole, Aripiprex, NSC-759266, OPC-14597, OPC-31'}, {'UUID': 'DrugGeneTargets_v2_2620', 'drugName': 'Aripiprazole', 'tradeNames_string': 'Abilify, Abilify maintena, Abilify maintena kit, Abilify mycite kit, Aripiprazole', 'drugSynonyms_string': 'Abilify mycite, Aripiprazole, Aripiprex, NSC-759266, OPC-14597, OPC-31'}, {'UUID': 'DrugGeneTargets_v2_2621', 'drugName': 'Aripiprazole', 'tradeNames_string': 'Abilify, Abilify maintena, Abilify maintena kit, Abilify mycite kit, Aripiprazole', 'drugSynonyms_string': 'Abilify mycite, Aripiprazole, Aripiprex, NSC-759266, OPC-14597, OPC-31'}, {'UUID': 'DrugGeneTargets_v2_4679', 'drugName': 'Aripiprazole Lauroxil', 'tradeNames_string': 'Aristada, Aristada initio kit', 'drugSynonyms_string': 'ALKS 9072, ALKS-9070, ALKS-9072, Aripiprazole lauroxil, Aristada initio, RDC-3317, RDC3317'}, {'UUID': 'DrugGeneTargets_v2_4680', 'drugName': 'Aripiprazole Lauroxil', 'tradeNames_string': 'Aristada, Aristada initio kit', 'drugSynonyms_string': 'ALKS 9072, ALKS-9070, ALKS-9072, Aripiprazole lauroxil, Aristada initio, RDC-3317, RDC3317'}, {'UUID': 'DrugGeneTargets_v2_4681', 'drugName': 'Aripiprazole Lauroxil', 'tradeNames_string': 'Aristada, Aristada initio kit', 'drugSynonyms_string': 'ALKS 9072, ALKS-9070, ALKS-9072, Aripiprazole lauroxil, Aristada initio, RDC-3317, RDC3317'}] | general | Distinct, Similarity Search | Metadata |
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