uuid stringlengths 4 8 | template_uuid stringclasses 40
values | question stringlengths 13 193 | answer stringlengths 29 2.2k | benchmark_query stringlengths 133 622 | execution_results stringlengths 2 1.14M | query_type stringclasses 2
values | sql_category stringclasses 26
values | bio_category stringclasses 14
values |
|---|---|---|---|---|---|---|---|---|
Q11.1746 | Q11 | Are there any CTD-2545M3.8 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene CTD-2545M3.8 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'CTD-2545M3.8' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.697 | Q11 | Are there any SLC10A4 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex, Prefrontal Cortex, Tibial Nerve and Skeletal Muscle samples tested there are no SNPs within the gene SLC10A4 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'SLC10A4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1632 | Q11 | Are there any STOX2 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood and Liver samples tested there are no SNPs within the gene STOX2 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'STOX2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1877 | Q11 | Are there any CRLF3 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex, Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Tibial Nerve, Multi Ancestry Whole Brain, Hypothalamus, Anterior Cingulate Cortex BA24, Amygdala and Nucleus Accumbens Basal samples tested there are no SNPs within the gene CRLF3 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'CRLF3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.696 | Q11 | Are there any RGS13 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene RGS13 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'RGS13' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.858 | Q11 | Are there any HAX1 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Cortex, Multi Ancestry Whole Brain and Whole Blood samples tested there are no SNPs within the gene HAX1 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'HAX1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.162 | Q11 | Are there any CYP4F8 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex and Prefrontal Cortex samples tested there are no SNPs within the gene CYP4F8 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'CYP4F8' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.902 | Q11 | Are there any RP11-321E2.4 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene RP11-321E2.4 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'RP11-321E2.4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1576 | Q11 | Are there any PIK3CB SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Multi Ancestry Whole Brain and Whole Blood samples tested there are no SNPs within the gene PIK3CB that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'PIK3CB' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.260 | Q11 | Are there any KATNA1 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex and Skeletal Muscle samples tested there are no SNPs within the gene KATNA1 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'KATNA1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.339 | Q11 | Are there any BMP8A SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex and Tibial Nerve samples tested there are no SNPs within the gene BMP8A that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'BMP8A' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1881 | Q11 | Are there any RP13-93L13.2 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene RP13-93L13.2 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'RP13-93L13.2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1048 | Q11 | Are there any NCF1B SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene NCF1B that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'NCF1B' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.521 | Q11 | Are there any PTPRJ SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex, Tibial Nerve and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene PTPRJ that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'PTPRJ' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1363 | Q11 | Are there any RNF151 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain, Whole Blood and Cortex samples tested there are no SNPs within the gene RNF151 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'RNF151' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1024 | Q11 | Are there any TRGJ1 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene TRGJ1 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'TRGJ1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.775 | Q11 | Are there any TTC19 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the TTC19 gene has 1 SNP that is statistically significant in Parkinson's Disease:
• rs11078331
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 2.07e-06; HEIDI: 6.3673e-05 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'TTC19' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1435717', 'Gene': 'TTC19', 'topRSID': 'rs11078331', 'p_SMR_multi': 2.065432e-06, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'p_HEIDI': 6.367344e-05}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1748 | Q11 | Are there any CASKIN1 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene CASKIN1 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'CASKIN1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.768 | Q11 | Are there any UCHL5 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene UCHL5 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'UCHL5' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1256 | Q11 | Are there any UBDP1 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene UBDP1 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'UBDP1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1213 | Q11 | Are there any DNAJC21 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex, Tibial Nerve, Skeletal Muscle and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene DNAJC21 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'DNAJC21' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1469 | Q11 | Are there any HIP1R SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the HIP1R gene has 1 SNP that is statistically significant in Parkinson's Disease:
• rs10847864
• Cerebellum: Adjusted SMR multi-SNP P-value: 1.64e-07; HEIDI: 6.6299e-01 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'HIP1R' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_20980', 'Gene': 'HIP1R', 'topRSID': 'rs10847864', 'p_SMR_multi': 1.644024e-07, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': 0.6629918}, {'UUID': 'NDD_SMR_genes_all_update_text_1709448', 'Gene': 'HIP1R', 'topRSID': 'rs10847864', 'p_SMR_multi': 2.068632e-06, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': 0.05608517}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1984 | Q11 | Are there any UGT2B7 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex and Prefrontal Cortex samples tested there are no SNPs within the gene UGT2B7 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'UGT2B7' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.527 | Q11 | Are there any RP11-226P1.2 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Prefrontal Cortex samples tested there are no SNPs within the gene RP11-226P1.2 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'RP11-226P1.2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.23 | Q11 | Are there any NAAA SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the NAAA gene has 1 SNP that is statistically significant in Parkinson's Disease:
• rs11732759
• Whole Blood: Adjusted SMR multi-SNP P-value: 3.53e-07; HEIDI: 3.9148e-03 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'NAAA' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1555885', 'Gene': 'NAAA', 'topRSID': 'rs11732759', 'p_SMR_multi': 3.5262e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.003914818}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.361 | Q11 | Are there any PRKAR1A SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Brain, Skeletal Muscle, Multi Ancestry Whole Brain and Whole Blood samples tested there are no SNPs within the gene PRKAR1A that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'PRKAR1A' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1288 | Q11 | Are there any C21orf67 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Frontal Cortex, Prefrontal Cortex, Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain, Hypothalamus, Anterior Cingulate Cortex BA24 and Nucleus Accumbens Basal samples tested there are no SNPs within the gene C21orf67 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'C21orf67' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1326 | Q11 | Are there any MARK4 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the MARK4 gene has 4 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs10409232
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.73e-11; HEIDI: 2.7206e-14
• rs12459074
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.62e-07; HEIDI: 2.4969e-08
• rs344806
• Whole Blood: Adjusted SMR multi-SNP P-value: 4.89e-07; HEIDI: 1.0352e-06
• rs2041262
• Whole Brain: Adjusted SMR multi-SNP P-value: 1.18e-06; HEIDI: 1.2108e-12
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'MARK4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_637449', 'Gene': 'MARK4', 'topRSID': 'rs10409232', 'p_SMR_multi': 1.728605e-11, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 2.720626e-14}, {'UUID': 'NDD_SMR_genes_all_update_text_637454', 'Gene': 'MARK4', 'topRSID': 'rs12459074', 'p_SMR_multi': 2.622366e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 2.496883e-08}, {'UUID': 'NDD_SMR_genes_all_update_text_1503916', 'Gene': 'MARK4', 'topRSID': 'rs344806', 'p_SMR_multi': 4.892338e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 1.03524e-06}, {'UUID': 'NDD_SMR_genes_all_update_text_122480', 'Gene': 'MARK4', 'topRSID': 'rs2041262', 'p_SMR_multi': 1.177207e-06, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 1.210811e-12}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1683 | Q11 | Are there any ZMPSTE24 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Cortex, Multi Ancestry Whole Brain, Whole Blood and Whole Brain samples tested there are no SNPs within the gene ZMPSTE24 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'ZMPSTE24' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.344 | Q11 | Are there any SERPINA4 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene SERPINA4 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'SERPINA4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.437 | Q11 | Are there any NOL12 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood and Prefrontal Cortex samples tested there are no SNPs within the gene NOL12 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'NOL12' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.479 | Q11 | Are there any P2RX4 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex, Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Tibial Nerve, Skeletal Muscle and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene P2RX4 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'P2RX4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.220 | Q11 | Are there any CORO6 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex, Prefrontal Cortex, Multi Ancestry Whole Brain and Cerebellum samples tested there are no SNPs within the gene CORO6 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'CORO6' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.919 | Q11 | Are there any RIIAD1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Cortex, Prefrontal Cortex, Caudate Basal Ganglia, Putamen Basal Ganglia, Amygdala, Whole Brain and Nucleus Accumbens Basal samples tested there are no SNPs within the gene RIIAD1 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'RIIAD1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1237 | Q11 | Are there any RN7SL199P SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the RN7SL199P gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs199447
• Prefrontal Cortex: Adjusted SMR multi-SNP P-value: 3.95e-07; HEIDI: 1.1216e-02 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'RN7SL199P' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1203021', 'Gene': 'RN7SL199P', 'topRSID': 'rs199447', 'p_SMR_multi': 3.952554e-07, 'Omic_tissue': 'Prefrontal Cortex', 'p_HEIDI': 0.01121612}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1597 | Q11 | Are there any ZNF485 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene ZNF485 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'ZNF485' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1020 | Q11 | Are there any KANSL2 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex, Cerebellar Hemisphere, Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain and Liver samples tested there are no SNPs within the gene KANSL2 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'KANSL2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1950 | Q11 | Are there any RP11-798G7.8 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the RP11-798G7.8 gene has 5 SNPs that are statistically significant in Parkinson's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs62055937
• Skeletal Muscle: Adjusted SMR multi-SNP P-value: 9.49e-10; HEIDI: -9.9990e+03
• rs16940672
• Whole Brain: Adjusted SMR multi-SNP P-value: 9.64e-10; HEIDI: 3.5602e-05
• rs6503443
• Cerebellar Hemisphere: Adjusted SMR multi-SNP P-value: 6.65e-09; HEIDI: 6.8928e-02
• rs113564729
• Whole Blood: Adjusted SMR multi-SNP P-value: 7.04e-09; HEIDI: 5.9720e-11
• rs6503453
• Tibial Nerve: Adjusted SMR multi-SNP P-value: 1.36e-08; HEIDI: 1.0875e-08
• Cerebellum: Adjusted SMR multi-SNP P-value: 8.77e-07; HEIDI: 9.1970e-06
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'RP11-798G7.8' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1370538', 'Gene': 'RP11-798G7.8', 'topRSID': 'rs62055937', 'p_SMR_multi': 9.490696e-10, 'Omic_tissue': 'Skeletal Muscle', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1640215', 'Gene': 'RP11-798G7.8', 'topRSID': 'rs16940672', 'p_SMR_multi': 9.642483e-10, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 3.560198e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_1191165', 'Gene': 'RP11-798G7.8', 'topRSID': 'rs6503443', 'p_SMR_multi': 6.649033e-09, 'Omic_tissue': 'Cerebellar Hemisphere', 'p_HEIDI': 0.06892782}, {'UUID': 'NDD_SMR_genes_all_update_text_1564778', 'Gene': 'RP11-798G7.8', 'topRSID': 'rs113564729', 'p_SMR_multi': 7.036133e-09, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 5.972018e-11}, {'UUID': 'NDD_SMR_genes_all_update_text_1328925', 'Gene': 'RP11-798G7.8', 'topRSID': 'rs6503453', 'p_SMR_multi': 1.361595e-08, 'Omic_tissue': 'Tibial Nerve', 'p_HEIDI': 1.087544e-08}, {'UUID': 'NDD_SMR_genes_all_update_text_1710343', 'Gene': 'RP11-798G7.8', 'topRSID': 'rs6503453', 'p_SMR_multi': 8.772602e-07, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': 9.19701e-06}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.96 | Q11 | Are there any HOXB-AS4 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene HOXB-AS4 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'HOXB-AS4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1017 | Q11 | Are there any ARHGAP27 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the ARHGAP27 gene has 4 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs35489312
• Whole Blood: Adjusted SMR multi-SNP P-value: 5.52e-07; HEIDI: 1.4124e-02
• rs11012
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.39e-06; HEIDI: 1.5531e-02
• rs78026984
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.25e-06; HEIDI: 6.1904e-02
• rs62065394
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 2.90e-06; HEIDI: 1.9944e-01
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'ARHGAP27' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_591157', 'Gene': 'ARHGAP27', 'topRSID': 'rs35489312', 'p_SMR_multi': 5.523958e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.01412357}, {'UUID': 'NDD_SMR_genes_all_update_text_591156', 'Gene': 'ARHGAP27', 'topRSID': 'rs35489312', 'p_SMR_multi': 9.060511e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.02060621}, {'UUID': 'NDD_SMR_genes_all_update_text_591163', 'Gene': 'ARHGAP27', 'topRSID': 'rs11012', 'p_SMR_multi': 1.385153e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.0155306}, {'UUID': 'NDD_SMR_genes_all_update_text_591154', 'Gene': 'ARHGAP27', 'topRSID': 'rs78026984', 'p_SMR_multi': 2.248872e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.06190383}, {'UUID': 'NDD_SMR_genes_all_update_text_1396744', 'Gene': 'ARHGAP27', 'topRSID': 'rs62065394', 'p_SMR_multi': 2.904745e-06, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'p_HEIDI': 0.1994428}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1079 | Q11 | Are there any RP11-680F20.11 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Prefrontal Cortex and Whole Brain samples tested there are no SNPs within the gene RP11-680F20.11 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'RP11-680F20.11' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1101 | Q11 | Are there any AHRR SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex, Frontal Cortex, Skeletal Muscle and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene AHRR that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'AHRR' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1586 | Q11 | Are there any RP11-564C4.6 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Tibial Nerve, Hypothalamus, Liver, Whole Blood and Nucleus Accumbens Basal samples tested there are no SNPs within the gene RP11-564C4.6 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'RP11-564C4.6' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1321 | Q11 | Are there any STIM1 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex, Tibial Nerve and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene STIM1 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'STIM1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.703 | Q11 | Are there any RTEL1-TNFRSF6B SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene RTEL1-TNFRSF6B that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'RTEL1-TNFRSF6B' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1794 | Q11 | Are there any SLC16A6 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene SLC16A6 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'SLC16A6' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1005 | Q11 | Are there any BST1 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the BST1 gene has 1 SNP that is statistically significant in Parkinson's Disease:
• rs34559912
• Whole Blood: Adjusted SMR multi-SNP P-value: 7.48e-11; HEIDI: 1.5845e-01 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'BST1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1555730', 'Gene': 'BST1', 'topRSID': 'rs34559912', 'p_SMR_multi': 7.480451e-11, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.1584458}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.156 | Q11 | Are there any LIN7A SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain, Whole Blood and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene LIN7A that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'LIN7A' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1108 | Q11 | Are there any RP11-809O17.1 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Frontal Cortex, Prefrontal Cortex, Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Hippocampus, Substantia nigra, Hypothalamus, Liver, Anterior Cingulate Cortex BA24, Whole Blood, Amygdala, Whole Brain and Nucleus Accumbens Basal samples tested there are no SNPs within the gene RP11-809O17.1 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'RP11-809O17.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1719 | Q11 | Are there any C1QTNF7 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex, Prefrontal Cortex and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene C1QTNF7 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'C1QTNF7' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1998 | Q11 | Are there any C4orf51 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene C4orf51 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'C4orf51' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.796 | Q11 | Are there any NOTCH4 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the NOTCH4 gene has 3 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs34562262
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.29e-07; HEIDI: 3.1089e-03
• rs9271619
• Whole Blood: Adjusted SMR multi-SNP P-value: 3.74e-07; HEIDI: 5.7676e-04
• rs9271663
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.19e-06; HEIDI: 7.8770e-03
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'NOTCH4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_621620', 'Gene': 'NOTCH4', 'topRSID': 'rs34562262', 'p_SMR_multi': 1.292283e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.003108897}, {'UUID': 'NDD_SMR_genes_all_update_text_621617', 'Gene': 'NOTCH4', 'topRSID': 'rs9271619', 'p_SMR_multi': 3.736813e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.0005767593}, {'UUID': 'NDD_SMR_genes_all_update_text_621629', 'Gene': 'NOTCH4', 'topRSID': 'rs9271663', 'p_SMR_multi': 2.186115e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.007876985}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.587 | Q11 | Are there any FBXL5 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the FBXL5 gene has 2 SNPs that are statistically significant in Parkinson's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs62290605
• Whole Blood: Adjusted SMR multi-SNP P-value: 5.35e-08; HEIDI: 1.9065e-05
• rs6850422
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.39e-06; HEIDI: 3.4350e-05
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'FBXL5' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1555728', 'Gene': 'FBXL5', 'topRSID': 'rs62290605', 'p_SMR_multi': 5.350197e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 1.906549e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_997634', 'Gene': 'FBXL5', 'topRSID': 'rs6850422', 'p_SMR_multi': 2.394558e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 3.434998e-05}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.710 | Q11 | Are there any MAPT-AS1 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | Yes, the MAPT-AS1 gene has 6 SNPs that are statistically significant in Progressive supranuclear palsy. Here are the SNPs along with their adjusted SMR p-values:
• rs415430
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.17e-28; HEIDI: 2.3757e-07
• rs169201
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.87e-24; HEIDI: 1.1486e-06
• rs1981997
• Whole Brain: Adjusted SMR multi-SNP P-value: 1.54e-18; HEIDI: -9.9990e+03
• Hypothalamus: Adjusted SMR multi-SNP P-value: 5.20e-11; HEIDI: 2.2109e-07
• rs393152
• Nucleus Accumbens Basal: Adjusted SMR multi-SNP P-value: 6.30e-14; HEIDI: 3.2982e-13
• Caudate Basal Ganglia: Adjusted SMR multi-SNP P-value: 1.59e-09; HEIDI: 4.7026e-06
• rs11012
• Skeletal Muscle: Adjusted SMR multi-SNP P-value: 2.76e-11; HEIDI: 2.4408e-03
• rs12373139
• Whole Brain: Adjusted SMR multi-SNP P-value: 1.10e-07; HEIDI: -9.9990e+03
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'MAPT-AS1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1041727', 'Gene': 'MAPT-AS1', 'topRSID': 'rs415430', 'p_SMR_multi': 1.165767e-28, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 2.375653e-07}, {'UUID': 'NDD_SMR_genes_all_update_text_1041730', 'Gene': 'MAPT-AS1', 'topRSID': 'rs169201', 'p_SMR_multi': 2.8666459999999998e-24, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 1.148598e-06}, {'UUID': 'NDD_SMR_genes_all_update_text_1041728', 'Gene': 'MAPT-AS1', 'topRSID': 'rs169201', 'p_SMR_multi': 4.351189e-23, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 6.134486e-08}, {'UUID': 'NDD_SMR_genes_all_update_text_560854', 'Gene': 'MAPT-AS1', 'topRSID': 'rs1981997', 'p_SMR_multi': 1.544458e-18, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1041726', 'Gene': 'MAPT-AS1', 'topRSID': 'rs169201', 'p_SMR_multi': 1.882031e-14, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 3.562272e-08}, {'UUID': 'NDD_SMR_genes_all_update_text_1732394', 'Gene': 'MAPT-AS1', 'topRSID': 'rs393152', 'p_SMR_multi': 6.295433e-14, 'Omic_tissue': 'Nucleus Accumbens Basal', 'p_HEIDI': 3.298201e-13}, {'UUID': 'NDD_SMR_genes_all_update_text_560853', 'Gene': 'MAPT-AS1', 'topRSID': 'rs1981997', 'p_SMR_multi': 3.057081e-12, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1375928', 'Gene': 'MAPT-AS1', 'topRSID': 'rs11012', 'p_SMR_multi': 2.764951e-11, 'Omic_tissue': 'Skeletal Muscle', 'p_HEIDI': 0.00244082}, {'UUID': 'NDD_SMR_genes_all_update_text_1464417', 'Gene': 'MAPT-AS1', 'topRSID': 'rs1981997', 'p_SMR_multi': 5.200702e-11, 'Omic_tissue': 'Hypothalamus', 'p_HEIDI': 2.210853e-07}, {'UUID': 'NDD_SMR_genes_all_update_text_1283701', 'Gene': 'MAPT-AS1', 'topRSID': 'rs393152', 'p_SMR_multi': 1.594923e-09, 'Omic_tissue': 'Caudate Basal Ganglia', 'p_HEIDI': 4.702647e-06}, {'UUID': 'NDD_SMR_genes_all_update_text_1041729', 'Gene': 'MAPT-AS1', 'topRSID': 'rs169201', 'p_SMR_multi': 6.797631e-09, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.2503576}, {'UUID': 'NDD_SMR_genes_all_update_text_560852', 'Gene': 'MAPT-AS1', 'topRSID': 'rs1981997', 'p_SMR_multi': 7.283735e-09, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_560850', 'Gene': 'MAPT-AS1', 'topRSID': 'rs12373139', 'p_SMR_multi': 1.098773e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_560851', 'Gene': 'MAPT-AS1', 'topRSID': 'rs12373139', 'p_SMR_multi': 1.960933e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': -9999.0}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1222 | Q11 | Are there any DOK6 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene DOK6 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'DOK6' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1308 | Q11 | Are there any RP11-517P14.2 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain, Frontal Cortex, Prefrontal Cortex, Cortex, Tibial Nerve, Skeletal Muscle, Whole Blood, Amygdala, Cerebellum and Nucleus Accumbens Basal samples tested there are no SNPs within the gene RP11-517P14.2 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'RP11-517P14.2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1666 | Q11 | Are there any TRAF7 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene TRAF7 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'TRAF7' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1270 | Q11 | Are there any RP5-1180C18.1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene RP5-1180C18.1 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'RP5-1180C18.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.493 | Q11 | Are there any C16orf13 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cerebellar Hemisphere, Prefrontal Cortex, Cortex, Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain, Hypothalamus and Cerebellum samples tested there are no SNPs within the gene C16orf13 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'C16orf13' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.565 | Q11 | Are there any RP11-78B10.2 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the RP11-78B10.2 gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs6672474
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.99e-07; HEIDI: 1.0680e-15 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'RP11-78B10.2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1491153', 'Gene': 'RP11-78B10.2', 'topRSID': 'rs6672474', 'p_SMR_multi': 1.988645e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 1.068048e-15}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1151 | Q11 | Are there any XPR1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene XPR1 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'XPR1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1129 | Q11 | Are there any HDC SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene HDC that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'HDC' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.808 | Q11 | Are there any CTD-2555A7.3 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene CTD-2555A7.3 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'CTD-2555A7.3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.518 | Q11 | Are there any RP11-96C23.11 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Tibial Nerve, Skeletal Muscle and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene RP11-96C23.11 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'RP11-96C23.11' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.640 | Q11 | Are there any RP1-18D14.7 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood and Tibial Nerve samples tested there are no SNPs within the gene RP1-18D14.7 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'RP1-18D14.7' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1480 | Q11 | Are there any RNF121 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene RNF121 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'RNF121' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1789 | Q11 | Are there any OR7G2 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain samples tested there are no SNPs within the gene OR7G2 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'OR7G2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1546 | Q11 | Are there any APOC4 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the APOC4 gene has 9 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs5120
• Whole Blood: Adjusted SMR multi-SNP P-value: 3.10e-20; HEIDI: 3.5519e-17
• rs10402642
• Cortex: Adjusted SMR multi-SNP P-value: 4.72e-16; HEIDI: 1.2404e-11
• rs11878597
• Whole Brain: Adjusted SMR multi-SNP P-value: 1.94e-13; HEIDI: 5.9012e-09
• rs73045696
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.19e-13; HEIDI: 8.9722e-08
• rs73045691
• Liver: Adjusted SMR multi-SNP P-value: 3.17e-11; HEIDI: 4.6883e-01
• rs7252480
• Cerebellum: Adjusted SMR multi-SNP P-value: 4.99e-11; HEIDI: 2.4856e-08
• Whole Brain: Adjusted SMR multi-SNP P-value: 5.09e-07; HEIDI: 4.6441e-04
• rs7259679
• Whole Brain: Adjusted SMR multi-SNP P-value: 2.48e-10; HEIDI: 8.6673e-10
• rs112391061
• Whole Brain: Adjusted SMR multi-SNP P-value: 1.45e-07; HEIDI: -9.9990e+03
• rs204482
• Whole Blood: Adjusted SMR multi-SNP P-value: 5.99e-07; HEIDI: 2.4283e-06
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'APOC4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_637435', 'Gene': 'APOC4', 'topRSID': 'rs5120', 'p_SMR_multi': 3.09724e-20, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 3.551854e-17}, {'UUID': 'NDD_SMR_genes_all_update_text_1108030', 'Gene': 'APOC4', 'topRSID': 'rs10402642', 'p_SMR_multi': 4.721456e-16, 'Omic_tissue': 'Cortex', 'p_HEIDI': 1.240352e-11}, {'UUID': 'NDD_SMR_genes_all_update_text_637433', 'Gene': 'APOC4', 'topRSID': 'rs5120', 'p_SMR_multi': 8.002815e-15, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 5.155316e-15}, {'UUID': 'NDD_SMR_genes_all_update_text_122468', 'Gene': 'APOC4', 'topRSID': 'rs11878597', 'p_SMR_multi': 1.942575e-13, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 5.901231e-09}, {'UUID': 'NDD_SMR_genes_all_update_text_637430', 'Gene': 'APOC4', 'topRSID': 'rs73045696', 'p_SMR_multi': 2.19402e-13, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 8.972214e-08}, {'UUID': 'NDD_SMR_genes_all_update_text_1466879', 'Gene': 'APOC4', 'topRSID': 'rs73045691', 'p_SMR_multi': 3.171686e-11, 'Omic_tissue': 'Liver', 'p_HEIDI': 0.4688313}, {'UUID': 'NDD_SMR_genes_all_update_text_4009', 'Gene': 'APOC4', 'topRSID': 'rs7252480', 'p_SMR_multi': 4.989487e-11, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': 2.48562e-08}, {'UUID': 'NDD_SMR_genes_all_update_text_122467', 'Gene': 'APOC4', 'topRSID': 'rs7259679', 'p_SMR_multi': 2.481681e-10, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 8.667319e-10}, {'UUID': 'NDD_SMR_genes_all_update_text_122465', 'Gene': 'APOC4', 'topRSID': 'rs112391061', 'p_SMR_multi': 1.454977e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_122466', 'Gene': 'APOC4', 'topRSID': 'rs7252480', 'p_SMR_multi': 5.086284e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.0004644108}, {'UUID': 'NDD_SMR_genes_all_update_text_637434', 'Gene': 'APOC4', 'topRSID': 'rs204482', 'p_SMR_multi': 5.994865e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 2.428296e-06}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1160 | Q11 | Are there any TMEM238L SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Cortex samples tested there are no SNPs within the gene TMEM238L that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'TMEM238L' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.797 | Q11 | Are there any OFCC1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene OFCC1 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'OFCC1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.119 | Q11 | Are there any PERM1 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Cortex samples tested there are no SNPs within the gene PERM1 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'PERM1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.747 | Q11 | Are there any RP11-799N11.1 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Prefrontal Cortex samples tested there are no SNPs within the gene RP11-799N11.1 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'RP11-799N11.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1691 | Q11 | Are there any RP11-18H21.2 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain and Prefrontal Cortex samples tested there are no SNPs within the gene RP11-18H21.2 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'RP11-18H21.2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1090 | Q11 | Are there any RP5-1042K10.12 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene RP5-1042K10.12 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'RP5-1042K10.12' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.837 | Q11 | Are there any TMPO-AS1 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene TMPO-AS1 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'TMPO-AS1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.122 | Q11 | Are there any SLC9C1 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood and Cortex samples tested there are no SNPs within the gene SLC9C1 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'SLC9C1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.663 | Q11 | Are there any RP11-280K24.6 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Prefrontal Cortex samples tested there are no SNPs within the gene RP11-280K24.6 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'RP11-280K24.6' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1908 | Q11 | Are there any RP11-388C12.5 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain samples tested there are no SNPs within the gene RP11-388C12.5 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'RP11-388C12.5' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.642 | Q11 | Are there any PIK3R6 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene PIK3R6 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'PIK3R6' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.374 | Q11 | Are there any AL133493.2 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Tibial Nerve and Cerebellum samples tested there are no SNPs within the gene AL133493.2 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'AL133493.2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.271 | Q11 | Are there any TEKT3 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Tibial Nerve, Skeletal Muscle, Substantia nigra, Hypothalamus, Putamen Basal Ganglia and Nucleus Accumbens Basal samples tested there are no SNPs within the gene TEKT3 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'TEKT3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.662 | Q11 | Are there any KIAA0556 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene KIAA0556 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'KIAA0556' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.944 | Q11 | Are there any RP11-456P18.2 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Blood and Cerebellum samples tested there are no SNPs within the gene RP11-456P18.2 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'RP11-456P18.2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.829 | Q11 | Are there any PMS2P1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the PMS2P1 gene has 2 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs7384878
• Whole Brain: Adjusted SMR multi-SNP P-value: 6.42e-15; HEIDI: 1.7959e-05
• rs2405442
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.21e-13; HEIDI: 6.3277e-01
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'PMS2P1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_74053', 'Gene': 'PMS2P1', 'topRSID': 'rs7384878', 'p_SMR_multi': 6.417134e-15, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 1.79595e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_585989', 'Gene': 'PMS2P1', 'topRSID': 'rs2405442', 'p_SMR_multi': 2.205734e-13, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.6327656}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.873 | Q11 | Are there any BRUNOL5 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene BRUNOL5 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'BRUNOL5' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.47 | Q11 | Are there any RP11-104J23.1 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene RP11-104J23.1 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'RP11-104J23.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1388 | Q11 | Are there any RPS21P8 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene RPS21P8 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'RPS21P8' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1709 | Q11 | Are there any GOLGA4 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Cortex, Prefrontal Cortex, Skeletal Muscle, Multi Ancestry Whole Brain, Whole Blood and Whole Brain samples tested there are no SNPs within the gene GOLGA4 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'GOLGA4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1000 | Q11 | Are there any SIX5 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Skeletal Muscle and Whole Blood samples tested there are no SNPs within the gene SIX5 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'SIX5' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.883 | Q11 | Are there any FAM83H SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Cerebellum, Hippocampus, Whole Brain, Whole Blood, Cortex, Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Multi Ancestry Whole Brain, Anterior Cingulate Cortex BA24, Amygdala and Nucleus Accumbens Basal samples tested there are no SNPs within the gene FAM83H that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'FAM83H' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.780 | Q11 | Are there any RP4-559A3.7 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene RP4-559A3.7 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'RP4-559A3.7' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1229 | Q11 | Are there any STAT4 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain, Cortex, Prefrontal Cortex, Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain and Whole Blood samples tested there are no SNPs within the gene STAT4 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'STAT4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.2000 | Q11 | Are there any AC005944.2 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene AC005944.2 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'AC005944.2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.5 | Q11 | Are there any RP11-705C15.2 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cerebellar Hemisphere, Prefrontal Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain, Hypothalamus, Amygdala, Cerebellum and Nucleus Accumbens Basal samples tested there are no SNPs within the gene RP11-705C15.2 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'RP11-705C15.2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1012 | Q11 | Are there any ANKDD1A SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Cerebellum, Whole Blood, Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Multi Ancestry Whole Brain and Whole Brain samples tested there are no SNPs within the gene ANKDD1A that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'ANKDD1A' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1724 | Q11 | Are there any OR12D2 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene OR12D2 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'OR12D2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.266 | Q11 | Are there any AC067945.4 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene AC067945.4 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'AC067945.4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1570 | Q11 | Are there any ARL17A SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the ARL17A gene has 20 SNPs that are statistically significant in Parkinson's Disease. Here are the top 10 SNPs along with their adjusted SMR p-values:
• rs2532233
• Cortex: Adjusted SMR multi-SNP P-value: 2.00e-15; HEIDI: -9.9990e+03
• rs58879558
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 3.03e-15; HEIDI: 1.6144e-01
• Cortex: Adjusted SMR multi-SNP P-value: 2.27e-11; HEIDI: 2.6749e-01
• Nucleus Accumbens Basal: Adjusted SMR multi-SNP P-value: 7.11e-11; HEIDI: 1.6951e-01
• rs4471723
• Cerebellum: Adjusted SMR multi-SNP P-value: 1.34e-13; HEIDI: -9.9990e+03
• rs55974014
• Cerebellum: Adjusted SMR multi-SNP P-value: 2.94e-12; HEIDI: 2.0927e-01
• rs56046792
• Cerebellar Hemisphere: Adjusted SMR multi-SNP P-value: 2.62e-11; HEIDI: 3.9823e-01
• rs62074125
• Whole Blood: Adjusted SMR multi-SNP P-value: 5.25e-11; HEIDI: 1.4556e-13
• Tibial Nerve: Adjusted SMR multi-SNP P-value: 8.73e-09; HEIDI: 3.3344e-13
• rs62053939
• Skeletal Muscle: Adjusted SMR multi-SNP P-value: 7.24e-11; HEIDI: -9.9990e+03
• rs17698176
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.00e-10; HEIDI: 7.9092e-11
• rs62056812
• Frontal Cortex: Adjusted SMR multi-SNP P-value: 2.86e-10; HEIDI: -9.9990e+03
• rs17573607
• Hypothalamus: Adjusted SMR multi-SNP P-value: 3.98e-10; HEIDI: 7.6442e-01
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'ARL17A' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1147260', 'Gene': 'ARL17A', 'topRSID': 'rs2532233', 'p_SMR_multi': 1.997904e-15, 'Omic_tissue': 'Cortex', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1435921', 'Gene': 'ARL17A', 'topRSID': 'rs58879558', 'p_SMR_multi': 3.034114e-15, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'p_HEIDI': 0.1614406}, {'UUID': 'NDD_SMR_genes_all_update_text_19651', 'Gene': 'ARL17A', 'topRSID': 'rs4471723', 'p_SMR_multi': 1.337634e-13, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1710358', 'Gene': 'ARL17A', 'topRSID': 'rs55974014', 'p_SMR_multi': 2.936298e-12, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': 0.209266}, {'UUID': 'NDD_SMR_genes_all_update_text_1262233', 'Gene': 'ARL17A', 'topRSID': 'rs58879558', 'p_SMR_multi': 2.266335e-11, 'Omic_tissue': 'Cortex', 'p_HEIDI': 0.2674944}, {'UUID': 'NDD_SMR_genes_all_update_text_1191180', 'Gene': 'ARL17A', 'topRSID': 'rs56046792', 'p_SMR_multi': 2.624651e-11, 'Omic_tissue': 'Cerebellar Hemisphere', 'p_HEIDI': 0.3982277}, {'UUID': 'NDD_SMR_genes_all_update_text_1564793', 'Gene': 'ARL17A', 'topRSID': 'rs62074125', 'p_SMR_multi': 5.250435e-11, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 1.455558e-13}, {'UUID': 'NDD_SMR_genes_all_update_text_1730073', 'Gene': 'ARL17A', 'topRSID': 'rs58879558', 'p_SMR_multi': 7.112257e-11, 'Omic_tissue': 'Nucleus Accumbens Basal', 'p_HEIDI': 0.1695124}, {'UUID': 'NDD_SMR_genes_all_update_text_1370553', 'Gene': 'ARL17A', 'topRSID': 'rs62053939', 'p_SMR_multi': 7.243335e-11, 'Omic_tissue': 'Skeletal Muscle', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_948920', 'Gene': 'ARL17A', 'topRSID': 'rs17698176', 'p_SMR_multi': 1.000148e-10, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 7.909193e-11}, {'UUID': 'NDD_SMR_genes_all_update_text_1168843', 'Gene': 'ARL17A', 'topRSID': 'rs62056812', 'p_SMR_multi': 2.856301e-10, 'Omic_tissue': 'Frontal Cortex', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1462903', 'Gene': 'ARL17A', 'topRSID': 'rs17573607', 'p_SMR_multi': 3.975815e-10, 'Omic_tissue': 'Hypothalamus', 'p_HEIDI': 0.7644244}, {'UUID': 'NDD_SMR_genes_all_update_text_1640230', 'Gene': 'ARL17A', 'topRSID': 'rs35732828', 'p_SMR_multi': 1.347916e-09, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 1.598166e-09}, {'UUID': 'NDD_SMR_genes_all_update_text_33018', 'Gene': 'ARL17A', 'topRSID': 'rs3785884', 'p_SMR_multi': 2.771664e-09, 'Omic_tissue': 'Hippocampus', 'p_HEIDI': 0.2724067}, {'UUID': 'NDD_SMR_genes_all_update_text_1281363', 'Gene': 'ARL17A', 'topRSID': 'rs2942166', 'p_SMR_multi': 3.271795e-09, 'Omic_tissue': 'Caudate Basal Ganglia', 'p_HEIDI': 0.2822658}, {'UUID': 'NDD_SMR_genes_all_update_text_27186', 'Gene': 'ARL17A', 'topRSID': 'rs56127309', 'p_SMR_multi': 6.023346e-09, 'Omic_tissue': 'Basal Ganglia', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1242288', 'Gene': 'ARL17A', 'topRSID': 'rs3874943', 'p_SMR_multi': 7.071586e-09, 'Omic_tissue': 'Prefrontal Cortex', 'p_HEIDI': 1.616123e-10}, {'UUID': 'NDD_SMR_genes_all_update_text_1328942', 'Gene': 'ARL17A', 'topRSID': 'rs62074125', 'p_SMR_multi': 8.729084e-09, 'Omic_tissue': 'Tibial Nerve', 'p_HEIDI': 3.334365e-13}, {'UUID': 'NDD_SMR_genes_all_update_text_1488148', 'Gene': 'ARL17A', 'topRSID': 'rs393152', 'p_SMR_multi': 1.985285e-08, 'Omic_tissue': 'Anterior Cingulate Cortex BA24', 'p_HEIDI': 0.9268638}, {'UUID': 'NDD_SMR_genes_all_update_text_1594932', 'Gene': 'ARL17A', 'topRSID': 'rs757055', 'p_SMR_multi': 4.337545e-08, 'Omic_tissue': 'Putamen Basal Ganglia', 'p_HEIDI': 0.6514905}, {'UUID': 'NDD_SMR_genes_all_update_text_1386998', 'Gene': 'ARL17A', 'topRSID': 'rs2942166', 'p_SMR_multi': 1.44486e-07, 'Omic_tissue': 'Hippocampus', 'p_HEIDI': 0.9950892}, {'UUID': 'NDD_SMR_genes_all_update_text_1603783', 'Gene': 'ARL17A', 'topRSID': 'rs8073146', 'p_SMR_multi': 3.096916e-07, 'Omic_tissue': 'Amygdala', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1476434', 'Gene': 'ARL17A', 'topRSID': 'rs17692129', 'p_SMR_multi': 4.613315e-07, 'Omic_tissue': 'Liver', 'p_HEIDI': 0.0001848796}, {'UUID': 'NDD_SMR_genes_all_update_text_30032', 'Gene': 'ARL17A', 'topRSID': 'rs6503453', 'p_SMR_multi': 1.073847e-06, 'Omic_tissue': 'Spinalcord', 'p_HEIDI': 4.66739e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_1679573', 'Gene': 'ARL17A', 'topRSID': 'rs62074125', 'p_SMR_multi': 1.590794e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 1.19096e-09}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1832 | Q11 | Are there any AIF1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the AIF1 gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs9267576
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.27e-06; HEIDI: 5.8105e-02 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'AIF1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_621023', 'Gene': 'AIF1', 'topRSID': 'rs9267576', 'p_SMR_multi': 1.268674e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.05810536}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.449 | Q11 | Are there any AC067968.3 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene AC067968.3 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'AC067968.3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
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