uuid stringlengths 4 8 | template_uuid stringclasses 40
values | question stringlengths 13 193 | answer stringlengths 29 2.2k | benchmark_query stringlengths 133 622 | execution_results stringlengths 2 1.14M | query_type stringclasses 2
values | sql_category stringclasses 26
values | bio_category stringclasses 14
values |
|---|---|---|---|---|---|---|---|---|
Q11.1954 | Q11 | Are there any THAP2 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene THAP2 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'THAP2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.954 | Q11 | Are there any ZNF461 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Cerebellum, Whole Blood, Cortex and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene ZNF461 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'ZNF461' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.172 | Q11 | Are there any MYL4 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Blood and Tibial Nerve samples tested there are no SNPs within the gene MYL4 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'MYL4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1406 | Q11 | Are there any CAMKMT SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex, Skeletal Muscle and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene CAMKMT that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'CAMKMT' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1207 | Q11 | Are there any MRP63 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Prefrontal Cortex, Skeletal Muscle and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene MRP63 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'MRP63' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1263 | Q11 | Are there any KANSL1-AS1 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the KANSL1-AS1 gene has 9 SNPs that are statistically significant in Parkinson's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs55974014
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 5.69e-16; HEIDI: 1.4916e-02
• Skeletal Muscle: Adjusted SMR multi-SNP P-value: 1.31e-15; HEIDI: 7.7233e-03
• Cortex: Adjusted SMR multi-SNP P-value: 5.03e-13; HEIDI: 6.7514e-01
• Nucleus Accumbens Basal: Adjusted SMR multi-SNP P-value: 1.08e-12; HEIDI: 7.2357e-02
• Putamen Basal Ganglia: Adjusted SMR multi-SNP P-value: 1.42e-12; HEIDI: 4.0248e-01
• Cerebellum: Adjusted SMR multi-SNP P-value: 2.32e-12; HEIDI: 7.3485e-01
• Cerebellar Hemisphere: Adjusted SMR multi-SNP P-value: 7.96e-12; HEIDI: 1.9775e-01
• rs2732615
• Prefrontal Cortex: Adjusted SMR multi-SNP P-value: 1.67e-15; HEIDI: 2.6966e-03
• rs2532233
• Whole Blood: Adjusted SMR multi-SNP P-value: 6.35e-15; HEIDI: 5.3542e-07
• rs1378358
• Whole Brain: Adjusted SMR multi-SNP P-value: 6.39e-15; HEIDI: 3.4598e-09
• rs199456
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.47e-14; HEIDI: 7.6797e-03
• Tibial Nerve: Adjusted SMR multi-SNP P-value: 9.21e-14; HEIDI: 3.5900e-03
• rs9468
• Liver: Adjusted SMR multi-SNP P-value: 2.20e-12; HEIDI: -9.9990e+03
• rs199533
• Caudate Basal Ganglia: Adjusted SMR multi-SNP P-value: 4.07e-12; HEIDI: 1.2173e-02
• Frontal Cortex: Adjusted SMR multi-SNP P-value: 9.22e-12; HEIDI: 4.9541e-03
• Hippocampus: Adjusted SMR multi-SNP P-value: 1.68e-11; HEIDI: 7.8540e-04
• Hypothalamus: Adjusted SMR multi-SNP P-value: 3.33e-11; HEIDI: 3.8299e-03
• Anterior Cingulate Cortex BA24: Adjusted SMR multi-SNP P-value: 6.63e-11; HEIDI: 9.0884e-03
• rs9896243
• Amygdala: Adjusted SMR multi-SNP P-value: 2.28e-10; HEIDI: 2.0364e-03
• rs12185243
• Substantia nigra: Adjusted SMR multi-SNP P-value: 9.56e-09; HEIDI: -9.9990e+03
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'KANSL1-AS1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1435918', 'Gene': 'KANSL1-AS1', 'topRSID': 'rs55974014', 'p_SMR_multi': 5.6905e-16, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'p_HEIDI': 0.01491641}, {'UUID': 'NDD_SMR_genes_all_update_text_1370546', 'Gene': 'KANSL1-AS1', 'topRSID': 'rs55974014', 'p_SMR_multi': 1.30958e-15, 'Omic_tissue': 'Skeletal Muscle', 'p_HEIDI': 0.007723259}, {'UUID': 'NDD_SMR_genes_all_update_text_1242277', 'Gene': 'KANSL1-AS1', 'topRSID': 'rs2732615', 'p_SMR_multi': 1.667997e-15, 'Omic_tissue': 'Prefrontal Cortex', 'p_HEIDI': 0.002696587}, {'UUID': 'NDD_SMR_genes_all_update_text_1564785', 'Gene': 'KANSL1-AS1', 'topRSID': 'rs2532233', 'p_SMR_multi': 6.350781e-15, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 5.354246e-07}, {'UUID': 'NDD_SMR_genes_all_update_text_1640222', 'Gene': 'KANSL1-AS1', 'topRSID': 'rs1378358', 'p_SMR_multi': 6.392017e-15, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 3.459837e-09}, {'UUID': 'NDD_SMR_genes_all_update_text_1679566', 'Gene': 'KANSL1-AS1', 'topRSID': 'rs199456', 'p_SMR_multi': 2.471419e-14, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.007679726}, {'UUID': 'NDD_SMR_genes_all_update_text_1328934', 'Gene': 'KANSL1-AS1', 'topRSID': 'rs199456', 'p_SMR_multi': 9.205373e-14, 'Omic_tissue': 'Tibial Nerve', 'p_HEIDI': 0.003589979}, {'UUID': 'NDD_SMR_genes_all_update_text_1262225', 'Gene': 'KANSL1-AS1', 'topRSID': 'rs55974014', 'p_SMR_multi': 5.034906e-13, 'Omic_tissue': 'Cortex', 'p_HEIDI': 0.6751382}, {'UUID': 'NDD_SMR_genes_all_update_text_1730065', 'Gene': 'KANSL1-AS1', 'topRSID': 'rs55974014', 'p_SMR_multi': 1.078886e-12, 'Omic_tissue': 'Nucleus Accumbens Basal', 'p_HEIDI': 0.07235706}, {'UUID': 'NDD_SMR_genes_all_update_text_1594924', 'Gene': 'KANSL1-AS1', 'topRSID': 'rs55974014', 'p_SMR_multi': 1.416904e-12, 'Omic_tissue': 'Putamen Basal Ganglia', 'p_HEIDI': 0.4024768}, {'UUID': 'NDD_SMR_genes_all_update_text_1476427', 'Gene': 'KANSL1-AS1', 'topRSID': 'rs9468', 'p_SMR_multi': 2.195508e-12, 'Omic_tissue': 'Liver', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1710350', 'Gene': 'KANSL1-AS1', 'topRSID': 'rs55974014', 'p_SMR_multi': 2.318566e-12, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': 0.7348483}, {'UUID': 'NDD_SMR_genes_all_update_text_1281355', 'Gene': 'KANSL1-AS1', 'topRSID': 'rs199533', 'p_SMR_multi': 4.067206e-12, 'Omic_tissue': 'Caudate Basal Ganglia', 'p_HEIDI': 0.01217283}, {'UUID': 'NDD_SMR_genes_all_update_text_1191172', 'Gene': 'KANSL1-AS1', 'topRSID': 'rs55974014', 'p_SMR_multi': 7.957344e-12, 'Omic_tissue': 'Cerebellar Hemisphere', 'p_HEIDI': 0.1977533}, {'UUID': 'NDD_SMR_genes_all_update_text_1168835', 'Gene': 'KANSL1-AS1', 'topRSID': 'rs199533', 'p_SMR_multi': 9.2192e-12, 'Omic_tissue': 'Frontal Cortex', 'p_HEIDI': 0.0049541}, {'UUID': 'NDD_SMR_genes_all_update_text_1386991', 'Gene': 'KANSL1-AS1', 'topRSID': 'rs199533', 'p_SMR_multi': 1.677659e-11, 'Omic_tissue': 'Hippocampus', 'p_HEIDI': 0.0007854035}, {'UUID': 'NDD_SMR_genes_all_update_text_1462895', 'Gene': 'KANSL1-AS1', 'topRSID': 'rs199533', 'p_SMR_multi': 3.33133e-11, 'Omic_tissue': 'Hypothalamus', 'p_HEIDI': 0.003829891}, {'UUID': 'NDD_SMR_genes_all_update_text_1488140', 'Gene': 'KANSL1-AS1', 'topRSID': 'rs199533', 'p_SMR_multi': 6.633594e-11, 'Omic_tissue': 'Anterior Cingulate Cortex BA24', 'p_HEIDI': 0.009088412}, {'UUID': 'NDD_SMR_genes_all_update_text_1603776', 'Gene': 'KANSL1-AS1', 'topRSID': 'rs9896243', 'p_SMR_multi': 2.280565e-10, 'Omic_tissue': 'Amygdala', 'p_HEIDI': 0.002036426}, {'UUID': 'NDD_SMR_genes_all_update_text_1451663', 'Gene': 'KANSL1-AS1', 'topRSID': 'rs12185243', 'p_SMR_multi': 9.562358e-09, 'Omic_tissue': 'Substantia nigra', 'p_HEIDI': -9999.0}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1400 | Q11 | Are there any AKAIN1 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Cerebellum and Cortex samples tested there are no SNPs within the gene AKAIN1 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'AKAIN1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.920 | Q11 | Are there any FGGY SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex, Prefrontal Cortex, Tibial Nerve, Skeletal Muscle and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene FGGY that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'FGGY' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.497 | Q11 | Are there any AC098820.2 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene AC098820.2 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'AC098820.2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.962 | Q11 | Are there any RP11-542C16.2 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene RP11-542C16.2 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'RP11-542C16.2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1106 | Q11 | Are there any APOPT1 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Frontal Cortex, Prefrontal Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Hippocampus, Multi Ancestry Whole Brain, Liver, Putamen Basal Ganglia and Nucleus Accumbens Basal samples tested there are no SNPs within the gene APOPT1 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'APOPT1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1041 | Q11 | Are there any RP11-399O19.9 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Prefrontal Cortex, Caudate Basal Ganglia, Whole Blood, Putamen Basal Ganglia and Nucleus Accumbens Basal samples tested there are no SNPs within the gene RP11-399O19.9 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'RP11-399O19.9' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.594 | Q11 | Are there any GPR107 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain, Cortex, Multi Ancestry Whole Brain and Whole Blood samples tested there are no SNPs within the gene GPR107 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'GPR107' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.757 | Q11 | Are there any RP11-389C8.2 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene RP11-389C8.2 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'RP11-389C8.2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.664 | Q11 | Are there any RP11-889L3.1 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain, Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Cortex, Caudate Basal Ganglia, Tibial Nerve, Multi Ancestry Whole Brain, Anterior Cingulate Cortex BA24, Whole Blood, Putamen Basal Ganglia, Amygdala, Cerebellum and Nucleus Accumbens Basal samples tested there are no SNPs within the gene RP11-889L3.1 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'RP11-889L3.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.237 | Q11 | Are there any POLM SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain, Cortex, Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain, Liver, Anterior Cingulate Cortex BA24, Whole Blood, Amygdala, Cerebellum and Nucleus Accumbens Basal samples tested there are no SNPs within the gene POLM that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'POLM' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.739 | Q11 | Are there any ADAM15 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the ADAM15 gene has 1 SNP that is statistically significant in Parkinson's Disease:
• rs11264305
• Whole Brain: Adjusted SMR multi-SNP P-value: 1.86e-06; HEIDI: 5.0548e-03 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'ADAM15' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_415490', 'Gene': 'ADAM15', 'topRSID': 'rs11264305', 'p_SMR_multi': 1.857978e-06, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.005054781}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1989 | Q11 | Are there any BECN1 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Tibial Nerve and Whole Blood samples tested there are no SNPs within the gene BECN1 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'BECN1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1633 | Q11 | Are there any LRRC37A SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | Yes, the LRRC37A gene has 5 SNPs that are statistically significant in Progressive supranuclear palsy. Here are the SNPs along with their adjusted SMR p-values:
• rs7225002
• Cortex: Adjusted SMR multi-SNP P-value: 3.50e-38; HEIDI: 6.5115e-33
• Tibial Nerve: Adjusted SMR multi-SNP P-value: 7.64e-21; HEIDI: 3.7607e-16
• Cerebellum: Adjusted SMR multi-SNP P-value: 8.47e-21; HEIDI: 7.8044e-15
• Cerebellar Hemisphere: Adjusted SMR multi-SNP P-value: 5.77e-17; HEIDI: 1.9188e-11
• Skeletal Muscle: Adjusted SMR multi-SNP P-value: 4.30e-14; HEIDI: 2.6389e-14
• Basal Ganglia: Adjusted SMR multi-SNP P-value: 6.05e-13; HEIDI: 2.2912e-08
• Whole Blood: Adjusted SMR multi-SNP P-value: 7.52e-12; HEIDI: 1.3863e-11
• Hypothalamus: Adjusted SMR multi-SNP P-value: 4.35e-11; HEIDI: 8.4045e-10
• Hippocampus: Adjusted SMR multi-SNP P-value: 6.31e-11; HEIDI: 2.1694e-07
• Frontal Cortex: Adjusted SMR multi-SNP P-value: 8.26e-11; HEIDI: 1.0346e-09
• Caudate Basal Ganglia: Adjusted SMR multi-SNP P-value: 1.31e-10; HEIDI: 1.5577e-08
• Nucleus Accumbens Basal: Adjusted SMR multi-SNP P-value: 6.08e-09; HEIDI: 6.1602e-09
• Substantia nigra: Adjusted SMR multi-SNP P-value: 7.75e-08; HEIDI: 1.4835e-05
• Putamen Basal Ganglia: Adjusted SMR multi-SNP P-value: 9.62e-08; HEIDI: 2.8760e-09
• Liver: Adjusted SMR multi-SNP P-value: 9.74e-08; HEIDI: 1.5390e-10
• Amygdala: Adjusted SMR multi-SNP P-value: 2.04e-07; HEIDI: 1.5664e-05
• Anterior Cingulate Cortex BA24: Adjusted SMR multi-SNP P-value: 2.24e-07; HEIDI: 7.5001e-09
• rs1981997
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 6.79e-37; HEIDI: 5.6052e-45
• rs169201
• Whole Brain: Adjusted SMR multi-SNP P-value: 2.25e-34; HEIDI: 7.5146e-10
• rs17692129
• Whole Blood: Adjusted SMR multi-SNP P-value: 3.31e-18; HEIDI: 6.3443e-16
• rs8070723
• Spinalcord: Adjusted SMR multi-SNP P-value: 2.85e-11; HEIDI: 1.3601e-06
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'LRRC37A' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1154398', 'Gene': 'LRRC37A', 'topRSID': 'rs7225002', 'p_SMR_multi': 3.495026e-38, 'Omic_tissue': 'Cortex', 'p_HEIDI': 6.511525e-33}, {'UUID': 'NDD_SMR_genes_all_update_text_1444274', 'Gene': 'LRRC37A', 'topRSID': 'rs1981997', 'p_SMR_multi': 6.786299e-37, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'p_HEIDI': 5.605194e-45}, {'UUID': 'NDD_SMR_genes_all_update_text_1646048', 'Gene': 'LRRC37A', 'topRSID': 'rs169201', 'p_SMR_multi': 2.247746e-34, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 7.514554e-10}, {'UUID': 'NDD_SMR_genes_all_update_text_1336296', 'Gene': 'LRRC37A', 'topRSID': 'rs7225002', 'p_SMR_multi': 7.636495e-21, 'Omic_tissue': 'Tibial Nerve', 'p_HEIDI': 3.760667e-16}, {'UUID': 'NDD_SMR_genes_all_update_text_22218', 'Gene': 'LRRC37A', 'topRSID': 'rs7225002', 'p_SMR_multi': 8.469841e-21, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': 7.804429e-15}, {'UUID': 'NDD_SMR_genes_all_update_text_1579426', 'Gene': 'LRRC37A', 'topRSID': 'rs17692129', 'p_SMR_multi': 3.3122350000000002e-18, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 6.344338e-16}, {'UUID': 'NDD_SMR_genes_all_update_text_1194221', 'Gene': 'LRRC37A', 'topRSID': 'rs7225002', 'p_SMR_multi': 5.768430000000001e-17, 'Omic_tissue': 'Cerebellar Hemisphere', 'p_HEIDI': 1.918771e-11}, {'UUID': 'NDD_SMR_genes_all_update_text_1714161', 'Gene': 'LRRC37A', 'topRSID': 'rs7225002', 'p_SMR_multi': 1.935107e-16, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': 1.614839e-11}, {'UUID': 'NDD_SMR_genes_all_update_text_1375934', 'Gene': 'LRRC37A', 'topRSID': 'rs7225002', 'p_SMR_multi': 4.300411e-14, 'Omic_tissue': 'Skeletal Muscle', 'p_HEIDI': 2.638922e-14}, {'UUID': 'NDD_SMR_genes_all_update_text_27913', 'Gene': 'LRRC37A', 'topRSID': 'rs7225002', 'p_SMR_multi': 6.047793e-13, 'Omic_tissue': 'Basal Ganglia', 'p_HEIDI': 2.29124e-08}, {'UUID': 'NDD_SMR_genes_all_update_text_1264987', 'Gene': 'LRRC37A', 'topRSID': 'rs7225002', 'p_SMR_multi': 1.701597e-12, 'Omic_tissue': 'Cortex', 'p_HEIDI': 2.216584e-11}, {'UUID': 'NDD_SMR_genes_all_update_text_1684939', 'Gene': 'LRRC37A', 'topRSID': 'rs7225002', 'p_SMR_multi': 7.518561e-12, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 1.386336e-11}, {'UUID': 'NDD_SMR_genes_all_update_text_30482', 'Gene': 'LRRC37A', 'topRSID': 'rs8070723', 'p_SMR_multi': 2.846173e-11, 'Omic_tissue': 'Spinalcord', 'p_HEIDI': 1.360096e-06}, {'UUID': 'NDD_SMR_genes_all_update_text_1464422', 'Gene': 'LRRC37A', 'topRSID': 'rs7225002', 'p_SMR_multi': 4.350176e-11, 'Omic_tissue': 'Hypothalamus', 'p_HEIDI': 8.404486e-10}, {'UUID': 'NDD_SMR_genes_all_update_text_33472', 'Gene': 'LRRC37A', 'topRSID': 'rs7225002', 'p_SMR_multi': 6.312069e-11, 'Omic_tissue': 'Hippocampus', 'p_HEIDI': 2.169444e-07}, {'UUID': 'NDD_SMR_genes_all_update_text_1170877', 'Gene': 'LRRC37A', 'topRSID': 'rs7225002', 'p_SMR_multi': 8.264816e-11, 'Omic_tissue': 'Frontal Cortex', 'p_HEIDI': 1.034575e-09}, {'UUID': 'NDD_SMR_genes_all_update_text_1283708', 'Gene': 'LRRC37A', 'topRSID': 'rs7225002', 'p_SMR_multi': 1.3141e-10, 'Omic_tissue': 'Caudate Basal Ganglia', 'p_HEIDI': 1.557683e-08}, {'UUID': 'NDD_SMR_genes_all_update_text_1388485', 'Gene': 'LRRC37A', 'topRSID': 'rs7225002', 'p_SMR_multi': 4.23872e-09, 'Omic_tissue': 'Hippocampus', 'p_HEIDI': 3.860671e-06}, {'UUID': 'NDD_SMR_genes_all_update_text_1732400', 'Gene': 'LRRC37A', 'topRSID': 'rs7225002', 'p_SMR_multi': 6.077261e-09, 'Omic_tissue': 'Nucleus Accumbens Basal', 'p_HEIDI': 6.160242e-09}, {'UUID': 'NDD_SMR_genes_all_update_text_1452485', 'Gene': 'LRRC37A', 'topRSID': 'rs7225002', 'p_SMR_multi': 7.746512e-08, 'Omic_tissue': 'Substantia nigra', 'p_HEIDI': 1.483522e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_1596827', 'Gene': 'LRRC37A', 'topRSID': 'rs7225002', 'p_SMR_multi': 9.620429e-08, 'Omic_tissue': 'Putamen Basal Ganglia', 'p_HEIDI': 2.876041e-09}, {'UUID': 'NDD_SMR_genes_all_update_text_1478191', 'Gene': 'LRRC37A', 'topRSID': 'rs7225002', 'p_SMR_multi': 9.736924e-08, 'Omic_tissue': 'Liver', 'p_HEIDI': 1.539013e-10}, {'UUID': 'NDD_SMR_genes_all_update_text_1604717', 'Gene': 'LRRC37A', 'topRSID': 'rs7225002', 'p_SMR_multi': 2.042688e-07, 'Omic_tissue': 'Amygdala', 'p_HEIDI': 1.566424e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_1489542', 'Gene': 'LRRC37A', 'topRSID': 'rs7225002', 'p_SMR_multi': 2.235972e-07, 'Omic_tissue': 'Anterior Cingulate Cortex BA24', 'p_HEIDI': 7.500079e-09}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1166 | Q11 | Are there any RP1-229K20.5 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the RP1-229K20.5 gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs2263333
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.33e-06; HEIDI: 2.1413e-05 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'RP1-229K20.5' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1494873', 'Gene': 'RP1-229K20.5', 'topRSID': 'rs2263333', 'p_SMR_multi': 1.328557e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 2.14129e-05}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1471 | Q11 | Are there any CTBP2 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex, Multi Ancestry Whole Brain and Cerebellum samples tested there are no SNPs within the gene CTBP2 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'CTBP2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1913 | Q11 | Are there any AC078852.2 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain samples tested there are no SNPs within the gene AC078852.2 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'AC078852.2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1628 | Q11 | Are there any ADORA1 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene ADORA1 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'ADORA1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.943 | Q11 | Are there any SGMS2 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood and Cortex samples tested there are no SNPs within the gene SGMS2 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'SGMS2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1219 | Q11 | Are there any MVP SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the MVP gene has 2 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs12920760
• Whole Blood: Adjusted SMR multi-SNP P-value: 4.84e-08; HEIDI: 2.8017e-05
• rs10204
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.93e-06; HEIDI: 3.0162e-04
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'MVP' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_577401', 'Gene': 'MVP', 'topRSID': 'rs12920760', 'p_SMR_multi': 4.844785e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 2.80169e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_1501435', 'Gene': 'MVP', 'topRSID': 'rs10204', 'p_SMR_multi': 2.926878e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.000301623}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1074 | Q11 | Are there any STX4 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the STX4 gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs58726213
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.06e-07; HEIDI: 4.2023e-06 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'STX4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1501474', 'Gene': 'STX4', 'topRSID': 'rs58726213', 'p_SMR_multi': 1.063079e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 4.202335e-06}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.111 | Q11 | Are there any OR6B1 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Cerebellum, Spinalcord, Whole Brain, Whole Blood, Cortex and Prefrontal Cortex samples tested there are no SNPs within the gene OR6B1 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'OR6B1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1944 | Q11 | Are there any SLC45A3 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene SLC45A3 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'SLC45A3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.574 | Q11 | Are there any MCM9 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Cerebellum, Whole Blood, Cortex, Prefrontal Cortex, Tibial Nerve, Skeletal Muscle and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene MCM9 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'MCM9' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1177 | Q11 | Are there any NR1H2 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene NR1H2 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'NR1H2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1184 | Q11 | Are there any RP11-736G13.1 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Prefrontal Cortex samples tested there are no SNPs within the gene RP11-736G13.1 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'RP11-736G13.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.897 | Q11 | Are there any OPN3 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain, Whole Blood, Tibial Nerve, Skeletal Muscle and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene OPN3 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'OPN3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.956 | Q11 | Are there any LRR1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene LRR1 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'LRR1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1057 | Q11 | Are there any LOC220429 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain samples tested there are no SNPs within the gene LOC220429 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'LOC220429' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1354 | Q11 | Are there any SLC25A41 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Cerebellum, Basal Ganglia, Whole Brain, Whole Blood, Cortex, Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Hippocampus, Liver, Anterior Cingulate Cortex BA24, Putamen Basal Ganglia, Amygdala and Nucleus Accumbens Basal samples tested there are no SNPs within the gene SLC25A41 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'SLC25A41' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1373 | Q11 | Are there any RP11-798G7.6 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | Yes, the RP11-798G7.6 gene has 3 SNPs that are statistically significant in Progressive supranuclear palsy. Here are the SNPs along with their adjusted SMR p-values:
• rs173365
• Whole Blood: Adjusted SMR multi-SNP P-value: 5.74e-14; HEIDI: -9.9990e+03
• rs169201
• Whole Brain: Adjusted SMR multi-SNP P-value: 2.68e-12; HEIDI: 4.1297e-12
• rs7220988
• Whole Blood: Adjusted SMR multi-SNP P-value: 8.96e-07; HEIDI: 1.0827e-04
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'RP11-798G7.6' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1579416', 'Gene': 'RP11-798G7.6', 'topRSID': 'rs173365', 'p_SMR_multi': 5.736935e-14, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1646039', 'Gene': 'RP11-798G7.6', 'topRSID': 'rs169201', 'p_SMR_multi': 2.68142e-12, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 4.129654e-12}, {'UUID': 'NDD_SMR_genes_all_update_text_1684930', 'Gene': 'RP11-798G7.6', 'topRSID': 'rs7220988', 'p_SMR_multi': 8.960125e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.0001082747}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1448 | Q11 | Are there any ACBD7 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex, Prefrontal Cortex and Tibial Nerve samples tested there are no SNPs within the gene ACBD7 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'ACBD7' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.891 | Q11 | Are there any GPR84 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene GPR84 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'GPR84' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1673 | Q11 | Are there any AMDHD1 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex, Tibial Nerve, Skeletal Muscle and Hippocampus samples tested there are no SNPs within the gene AMDHD1 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'AMDHD1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.857 | Q11 | Are there any ARHGEF26-AS1 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Prefrontal Cortex, Caudate Basal Ganglia, Tibial Nerve, Substantia nigra, Hypothalamus, Putamen Basal Ganglia, Cerebellum and Nucleus Accumbens Basal samples tested there are no SNPs within the gene ARHGEF26-AS1 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'ARHGEF26-AS1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.741 | Q11 | Are there any AC004899.1 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood and Prefrontal Cortex samples tested there are no SNPs within the gene AC004899.1 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'AC004899.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.724 | Q11 | Are there any RP11-296A18.3 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Prefrontal Cortex and Tibial Nerve samples tested there are no SNPs within the gene RP11-296A18.3 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'RP11-296A18.3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.460 | Q11 | Are there any CTD-3105H18.16 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood and Prefrontal Cortex samples tested there are no SNPs within the gene CTD-3105H18.16 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'CTD-3105H18.16' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.267 | Q11 | Are there any MCM7 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the MCM7 gene has 3 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs1527423
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.17e-12; HEIDI: 1.0939e-06
• Whole Brain: Adjusted SMR multi-SNP P-value: 7.92e-07; HEIDI: 5.7976e-05
• rs7807156
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.17e-10; HEIDI: 8.3545e-05
• rs3800951
• Whole Brain: Adjusted SMR multi-SNP P-value: 2.10e-09; HEIDI: 1.8532e-06
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'MCM7' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_585970', 'Gene': 'MCM7', 'topRSID': 'rs1527423', 'p_SMR_multi': 1.168901e-12, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 1.093887e-06}, {'UUID': 'NDD_SMR_genes_all_update_text_585969', 'Gene': 'MCM7', 'topRSID': 'rs7807156', 'p_SMR_multi': 1.165827e-10, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 8.354484e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_74026', 'Gene': 'MCM7', 'topRSID': 'rs3800951', 'p_SMR_multi': 2.098623e-09, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 1.853191e-06}, {'UUID': 'NDD_SMR_genes_all_update_text_74027', 'Gene': 'MCM7', 'topRSID': 'rs1527423', 'p_SMR_multi': 7.921772e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 5.797609e-05}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.78 | Q11 | Are there any RP11-120K24.3 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Cortex, Caudate Basal Ganglia, Whole Blood and Whole Brain samples tested there are no SNPs within the gene RP11-120K24.3 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'RP11-120K24.3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1785 | Q11 | Are there any OR2G3 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene OR2G3 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'OR2G3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.450 | Q11 | Are there any MS4A2 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the MS4A2 gene has 2 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs17528859
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.43e-16; HEIDI: 5.8711e-04
• rs540170
• Whole Brain: Adjusted SMR multi-SNP P-value: 2.63e-06; HEIDI: 1.7910e-02
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'MS4A2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1498260', 'Gene': 'MS4A2', 'topRSID': 'rs17528859', 'p_SMR_multi': 1.432735e-16, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.0005871116}, {'UUID': 'NDD_SMR_genes_all_update_text_91390', 'Gene': 'MS4A2', 'topRSID': 'rs540170', 'p_SMR_multi': 2.633968e-06, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.01790991}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.401 | Q11 | Are there any MOBKL2B SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | Yes, the MOBKL2B gene has 1 SNP that is statistically significant in Amyotrophic Lateral Sclerosis:
• rs10812605
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.86e-10; HEIDI: 3.3175e-03 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'MOBKL2B' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_745096', 'Gene': 'MOBKL2B', 'topRSID': 'rs10812605', 'p_SMR_multi': 2.860618e-10, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.003317498}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.179 | Q11 | Are there any RPL21 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain, Skeletal Muscle and Whole Blood samples tested there are no SNPs within the gene RPL21 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'RPL21' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1051 | Q11 | Are there any MYL9 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Tibial Nerve and Whole Blood samples tested there are no SNPs within the gene MYL9 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'MYL9' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1737 | Q11 | Are there any KRT79 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene KRT79 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'KRT79' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1609 | Q11 | Are there any AD000684.2 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Tibial Nerve and Whole Blood samples tested there are no SNPs within the gene AD000684.2 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'AD000684.2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1869 | Q11 | Are there any GPC2 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the GPC2 gene has 6 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs866500
• Whole Brain: Adjusted SMR multi-SNP P-value: 6.78e-09; HEIDI: 5.5705e-05
• rs3779045
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.22e-08; HEIDI: 5.6080e-03
• rs6943160
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.30e-08; HEIDI: 6.8966e-09
• rs34130487
• Whole Blood: Adjusted SMR multi-SNP P-value: 7.55e-08; HEIDI: 3.8575e-03
• rs17309333
• Cerebellum: Adjusted SMR multi-SNP P-value: 8.86e-07; HEIDI: 2.7250e-01
• rs6465765
• Whole Brain: Adjusted SMR multi-SNP P-value: 1.85e-06; HEIDI: 2.2932e-04
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'GPC2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_74045', 'Gene': 'GPC2', 'topRSID': 'rs866500', 'p_SMR_multi': 6.77721e-09, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 5.570468e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_585980', 'Gene': 'GPC2', 'topRSID': 'rs3779045', 'p_SMR_multi': 1.221726e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.005607984}, {'UUID': 'NDD_SMR_genes_all_update_text_585979', 'Gene': 'GPC2', 'topRSID': 'rs6943160', 'p_SMR_multi': 2.301873e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 6.896597e-09}, {'UUID': 'NDD_SMR_genes_all_update_text_1495799', 'Gene': 'GPC2', 'topRSID': 'rs34130487', 'p_SMR_multi': 7.549909e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.003857491}, {'UUID': 'NDD_SMR_genes_all_update_text_272', 'Gene': 'GPC2', 'topRSID': 'rs17309333', 'p_SMR_multi': 8.862247e-07, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': 0.2725038}, {'UUID': 'NDD_SMR_genes_all_update_text_74044', 'Gene': 'GPC2', 'topRSID': 'rs6465765', 'p_SMR_multi': 1.848751e-06, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.0002293151}, {'UUID': 'NDD_SMR_genes_all_update_text_74043', 'Gene': 'GPC2', 'topRSID': 'rs6465765', 'p_SMR_multi': 1.975338e-06, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 4.548647e-07}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.602 | Q11 | Are there any LOC154449 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene LOC154449 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'LOC154449' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.63 | Q11 | Are there any DCLRE1A SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Cortex, Prefrontal Cortex, Multi Ancestry Whole Brain, Whole Blood, Whole Brain and Nucleus Accumbens Basal samples tested there are no SNPs within the gene DCLRE1A that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'DCLRE1A' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1309 | Q11 | Are there any B4GALT1 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood and Skeletal Muscle samples tested there are no SNPs within the gene B4GALT1 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'B4GALT1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.879 | Q11 | Are there any ZNF708 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Cerebellum, Cerebellar Hemisphere, Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain, Liver and Whole Blood samples tested there are no SNPs within the gene ZNF708 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'ZNF708' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1491 | Q11 | Are there any NAT8B SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain samples tested there are no SNPs within the gene NAT8B that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'NAT8B' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1880 | Q11 | Are there any WNT3 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the WNT3 gene has 2 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs199520
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.34e-06; HEIDI: 7.0511e-05
• rs199523
• Tibial Nerve: Adjusted SMR multi-SNP P-value: 2.44e-06; HEIDI: 3.2390e-02
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'WNT3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1502460', 'Gene': 'WNT3', 'topRSID': 'rs199520', 'p_SMR_multi': 1.344385e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 7.051058e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_1291771', 'Gene': 'WNT3', 'topRSID': 'rs199523', 'p_SMR_multi': 2.436028e-06, 'Omic_tissue': 'Tibial Nerve', 'p_HEIDI': 0.03239027}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.282 | Q11 | Are there any JMJD1C SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene JMJD1C that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'JMJD1C' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.37 | Q11 | Are there any RP11-526A4.1 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene RP11-526A4.1 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'RP11-526A4.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1517 | Q11 | Are there any ZBTB7A SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene ZBTB7A that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'ZBTB7A' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.669 | Q11 | Are there any HOXC-AS1 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Tibial Nerve and Skeletal Muscle samples tested there are no SNPs within the gene HOXC-AS1 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'HOXC-AS1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1829 | Q11 | Are there any BYSL SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene BYSL that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'BYSL' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1446 | Q11 | Are there any MAPT SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the MAPT gene has 13 SNPs that are statistically significant in Alzheimer's Disease. Here are the top 10 SNPs along with their adjusted SMR p-values:
• rs2532276
• Prefrontal Cortex: Adjusted SMR multi-SNP P-value: 2.59e-08; HEIDI: 5.8909e-03
• rs55825513
• Whole Brain: Adjusted SMR multi-SNP P-value: 1.52e-07; HEIDI: 1.2041e-04
• rs62055936
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 2.03e-07; HEIDI: -9.9990e+03
• rs17689882
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.53e-07; HEIDI: 2.7233e-02
• rs111541901
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.69e-07; HEIDI: 7.3061e-02
• rs111751251
• Whole Blood: Adjusted SMR multi-SNP P-value: 3.08e-07; HEIDI: 7.3187e-02
• rs62056790
• Whole Blood: Adjusted SMR multi-SNP P-value: 3.12e-07; HEIDI: 9.0657e-02
• rs17650872
• Whole Brain: Adjusted SMR multi-SNP P-value: 4.32e-07; HEIDI: 6.4037e-01
• rs2532233
• Whole Blood: Adjusted SMR multi-SNP P-value: 4.34e-07; HEIDI: 4.9996e-01
• rs117646503
• Whole Blood: Adjusted SMR multi-SNP P-value: 6.88e-07; HEIDI: 2.2072e-01
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'MAPT' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1203008', 'Gene': 'MAPT', 'topRSID': 'rs2532276', 'p_SMR_multi': 2.589915e-08, 'Omic_tissue': 'Prefrontal Cortex', 'p_HEIDI': 0.0058909}, {'UUID': 'NDD_SMR_genes_all_update_text_1610864', 'Gene': 'MAPT', 'topRSID': 'rs55825513', 'p_SMR_multi': 1.518612e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.0001204107}, {'UUID': 'NDD_SMR_genes_all_update_text_1396748', 'Gene': 'MAPT', 'topRSID': 'rs62055936', 'p_SMR_multi': 2.02904e-07, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_591203', 'Gene': 'MAPT', 'topRSID': 'rs17689882', 'p_SMR_multi': 2.532079e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.02723276}, {'UUID': 'NDD_SMR_genes_all_update_text_591210', 'Gene': 'MAPT', 'topRSID': 'rs111541901', 'p_SMR_multi': 2.691411e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.07306081}, {'UUID': 'NDD_SMR_genes_all_update_text_591189', 'Gene': 'MAPT', 'topRSID': 'rs111751251', 'p_SMR_multi': 3.078484e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.07318684}, {'UUID': 'NDD_SMR_genes_all_update_text_591209', 'Gene': 'MAPT', 'topRSID': 'rs62056790', 'p_SMR_multi': 3.119546e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.09065659}, {'UUID': 'NDD_SMR_genes_all_update_text_591191', 'Gene': 'MAPT', 'topRSID': 'rs17689882', 'p_SMR_multi': 3.968428e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.0158721}, {'UUID': 'NDD_SMR_genes_all_update_text_115183', 'Gene': 'MAPT', 'topRSID': 'rs17650872', 'p_SMR_multi': 4.321768e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.6403735}, {'UUID': 'NDD_SMR_genes_all_update_text_591204', 'Gene': 'MAPT', 'topRSID': 'rs2532233', 'p_SMR_multi': 4.340116e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.4999633}, {'UUID': 'NDD_SMR_genes_all_update_text_591202', 'Gene': 'MAPT', 'topRSID': 'rs111751251', 'p_SMR_multi': 6.759956e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.04804293}, {'UUID': 'NDD_SMR_genes_all_update_text_591192', 'Gene': 'MAPT', 'topRSID': 'rs117646503', 'p_SMR_multi': 6.883101e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.2207176}, {'UUID': 'NDD_SMR_genes_all_update_text_591197', 'Gene': 'MAPT', 'topRSID': 'rs111751251', 'p_SMR_multi': 9.450977e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.02969893}, {'UUID': 'NDD_SMR_genes_all_update_text_115191', 'Gene': 'MAPT', 'topRSID': 'rs17651483', 'p_SMR_multi': 1.259526e-06, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.1842054}, {'UUID': 'NDD_SMR_genes_all_update_text_591187', 'Gene': 'MAPT', 'topRSID': 'rs17689882', 'p_SMR_multi': 1.798894e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.04451087}, {'UUID': 'NDD_SMR_genes_all_update_text_591196', 'Gene': 'MAPT', 'topRSID': 'rs111751251', 'p_SMR_multi': 1.805779e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.03870612}, {'UUID': 'NDD_SMR_genes_all_update_text_115166', 'Gene': 'MAPT', 'topRSID': 'rs2435204', 'p_SMR_multi': 1.808054e-06, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_591201', 'Gene': 'MAPT', 'topRSID': 'rs112572874', 'p_SMR_multi': 2.076175e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.02802182}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.986 | Q11 | Are there any RP11-156K13.3 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Frontal Cortex, Substantia nigra and Whole Blood samples tested there are no SNPs within the gene RP11-156K13.3 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'RP11-156K13.3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1572 | Q11 | Are there any HCG4P8 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene HCG4P8 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'HCG4P8' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.745 | Q11 | Are there any SALL4 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain, Whole Blood and Tibial Nerve samples tested there are no SNPs within the gene SALL4 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'SALL4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.194 | Q11 | Are there any PNISR SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain and Skeletal Muscle samples tested there are no SNPs within the gene PNISR that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'PNISR' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.927 | Q11 | Are there any AC104534.2 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene AC104534.2 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'AC104534.2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.462 | Q11 | Are there any SPAG7 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the SPAG7 gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs67501853
• Whole Blood: Adjusted SMR multi-SNP P-value: 3.95e-07; HEIDI: 2.4764e-05 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'SPAG7' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1501918', 'Gene': 'SPAG7', 'topRSID': 'rs67501853', 'p_SMR_multi': 3.950234e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 2.47639e-05}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.682 | Q11 | Are there any APOC1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the APOC1 gene has 2 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs1064725
• Whole Blood: Adjusted SMR multi-SNP P-value: 7.25e-07; HEIDI: -9.9990e+03
• rs892101
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 1.57e-06; HEIDI: 1.8286e-04
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'APOC1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_637428', 'Gene': 'APOC1', 'topRSID': 'rs1064725', 'p_SMR_multi': 7.245738e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1397647', 'Gene': 'APOC1', 'topRSID': 'rs892101', 'p_SMR_multi': 1.565257e-06, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'p_HEIDI': 0.0001828557}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.767 | Q11 | Are there any KCTD21 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Cerebellum, Basal Ganglia, Spinalcord, Whole Brain, Whole Blood, Cortex, Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Hippocampus, Multi Ancestry Whole Brain, Substantia nigra, Hypothalamus, Anterior Cingulate Cortex BA24, Putamen Basal Ganglia, Amygdala and Nucleus Accumbens Basal samples tested there are no SNPs within the gene KCTD21 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'KCTD21' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1809 | Q11 | Are there any ARL17B SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the ARL17B gene has 2 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs538628
• Cortex: Adjusted SMR multi-SNP P-value: 6.60e-08; HEIDI: 6.7381e-01
• rs7225002
• Cerebellum: Adjusted SMR multi-SNP P-value: 4.20e-07; HEIDI: 5.9375e-01
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'ARL17B' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1106832', 'Gene': 'ARL17B', 'topRSID': 'rs538628', 'p_SMR_multi': 6.598205e-08, 'Omic_tissue': 'Cortex', 'p_HEIDI': 0.6738135}, {'UUID': 'NDD_SMR_genes_all_update_text_2659', 'Gene': 'ARL17B', 'topRSID': 'rs7225002', 'p_SMR_multi': 4.203789e-07, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': 0.5937533}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1603 | Q11 | Are there any RP11-259G18.2 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | Yes, the RP11-259G18.2 gene has 2 SNPs that are statistically significant in Progressive supranuclear palsy. Here are the SNPs along with their adjusted SMR p-values:
• rs169201
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.48e-35; HEIDI: 7.0229e-07
• Whole Brain: Adjusted SMR multi-SNP P-value: 5.61e-32; HEIDI: 1.8215e-09
• Tibial Nerve: Adjusted SMR multi-SNP P-value: 1.67e-23; HEIDI: 8.4617e-08
• Caudate Basal Ganglia: Adjusted SMR multi-SNP P-value: 4.03e-18; HEIDI: 1.8063e-11
• Nucleus Accumbens Basal: Adjusted SMR multi-SNP P-value: 9.38e-18; HEIDI: 1.6104e-13
• Hippocampus: Adjusted SMR multi-SNP P-value: 8.32e-17; HEIDI: 6.7185e-13
• Hypothalamus: Adjusted SMR multi-SNP P-value: 8.20e-16; HEIDI: 1.1141e-12
• Frontal Cortex: Adjusted SMR multi-SNP P-value: 9.06e-16; HEIDI: 1.6176e-12
• Anterior Cingulate Cortex BA24: Adjusted SMR multi-SNP P-value: 3.00e-15; HEIDI: 7.4656e-10
• Amygdala: Adjusted SMR multi-SNP P-value: 1.89e-14; HEIDI: 2.7618e-11
• rs1981997
• Cerebellum: Adjusted SMR multi-SNP P-value: 4.56e-19; HEIDI: 1.1130e-20
• Liver: Adjusted SMR multi-SNP P-value: 1.47e-18; HEIDI: 3.2680e-15
• Cerebellar Hemisphere: Adjusted SMR multi-SNP P-value: 6.14e-18; HEIDI: 2.4119e-16
• Cortex: Adjusted SMR multi-SNP P-value: 2.16e-17; HEIDI: 8.8225e-18
• Putamen Basal Ganglia: Adjusted SMR multi-SNP P-value: 1.56e-15; HEIDI: 2.0031e-15
• Substantia nigra: Adjusted SMR multi-SNP P-value: 5.15e-11; HEIDI: 2.2018e-08
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'RP11-259G18.2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1579423', 'Gene': 'RP11-259G18.2', 'topRSID': 'rs169201', 'p_SMR_multi': 2.477035e-35, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 7.022902e-07}, {'UUID': 'NDD_SMR_genes_all_update_text_1684936', 'Gene': 'RP11-259G18.2', 'topRSID': 'rs169201', 'p_SMR_multi': 3.800151e-33, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 4.935575e-18}, {'UUID': 'NDD_SMR_genes_all_update_text_1646045', 'Gene': 'RP11-259G18.2', 'topRSID': 'rs169201', 'p_SMR_multi': 5.608603e-32, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 1.82152e-09}, {'UUID': 'NDD_SMR_genes_all_update_text_1336292', 'Gene': 'RP11-259G18.2', 'topRSID': 'rs169201', 'p_SMR_multi': 1.674611e-23, 'Omic_tissue': 'Tibial Nerve', 'p_HEIDI': 8.461725e-08}, {'UUID': 'NDD_SMR_genes_all_update_text_1714157', 'Gene': 'RP11-259G18.2', 'topRSID': 'rs1981997', 'p_SMR_multi': 4.556951e-19, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': 1.112994e-20}, {'UUID': 'NDD_SMR_genes_all_update_text_1478188', 'Gene': 'RP11-259G18.2', 'topRSID': 'rs1981997', 'p_SMR_multi': 1.474329e-18, 'Omic_tissue': 'Liver', 'p_HEIDI': 3.267957e-15}, {'UUID': 'NDD_SMR_genes_all_update_text_1283704', 'Gene': 'RP11-259G18.2', 'topRSID': 'rs169201', 'p_SMR_multi': 4.029124e-18, 'Omic_tissue': 'Caudate Basal Ganglia', 'p_HEIDI': 1.80629e-11}, {'UUID': 'NDD_SMR_genes_all_update_text_1194218', 'Gene': 'RP11-259G18.2', 'topRSID': 'rs1981997', 'p_SMR_multi': 6.139863e-18, 'Omic_tissue': 'Cerebellar Hemisphere', 'p_HEIDI': 2.411918e-16}, {'UUID': 'NDD_SMR_genes_all_update_text_1732396', 'Gene': 'RP11-259G18.2', 'topRSID': 'rs169201', 'p_SMR_multi': 9.380474e-18, 'Omic_tissue': 'Nucleus Accumbens Basal', 'p_HEIDI': 1.610369e-13}, {'UUID': 'NDD_SMR_genes_all_update_text_1264983', 'Gene': 'RP11-259G18.2', 'topRSID': 'rs1981997', 'p_SMR_multi': 2.1609260000000002e-17, 'Omic_tissue': 'Cortex', 'p_HEIDI': 8.822478e-18}, {'UUID': 'NDD_SMR_genes_all_update_text_1388483', 'Gene': 'RP11-259G18.2', 'topRSID': 'rs169201', 'p_SMR_multi': 8.322895e-17, 'Omic_tissue': 'Hippocampus', 'p_HEIDI': 6.718483e-13}, {'UUID': 'NDD_SMR_genes_all_update_text_1464419', 'Gene': 'RP11-259G18.2', 'topRSID': 'rs169201', 'p_SMR_multi': 8.195379e-16, 'Omic_tissue': 'Hypothalamus', 'p_HEIDI': 1.114055e-12}, {'UUID': 'NDD_SMR_genes_all_update_text_1170874', 'Gene': 'RP11-259G18.2', 'topRSID': 'rs169201', 'p_SMR_multi': 9.064537e-16, 'Omic_tissue': 'Frontal Cortex', 'p_HEIDI': 1.617579e-12}, {'UUID': 'NDD_SMR_genes_all_update_text_1596823', 'Gene': 'RP11-259G18.2', 'topRSID': 'rs1981997', 'p_SMR_multi': 1.562688e-15, 'Omic_tissue': 'Putamen Basal Ganglia', 'p_HEIDI': 2.003077e-15}, {'UUID': 'NDD_SMR_genes_all_update_text_1489539', 'Gene': 'RP11-259G18.2', 'topRSID': 'rs169201', 'p_SMR_multi': 3.003994e-15, 'Omic_tissue': 'Anterior Cingulate Cortex BA24', 'p_HEIDI': 7.465588e-10}, {'UUID': 'NDD_SMR_genes_all_update_text_1604714', 'Gene': 'RP11-259G18.2', 'topRSID': 'rs169201', 'p_SMR_multi': 1.88641e-14, 'Omic_tissue': 'Amygdala', 'p_HEIDI': 2.761821e-11}, {'UUID': 'NDD_SMR_genes_all_update_text_1452483', 'Gene': 'RP11-259G18.2', 'topRSID': 'rs1981997', 'p_SMR_multi': 5.151064e-11, 'Omic_tissue': 'Substantia nigra', 'p_HEIDI': 2.201778e-08}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.735 | Q11 | Are there any GRAMD4P7 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Prefrontal Cortex, Hypothalamus and Nucleus Accumbens Basal samples tested there are no SNPs within the gene GRAMD4P7 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'GRAMD4P7' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.418 | Q11 | Are there any AC051649.6 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Frontal Cortex, Cortex and Cerebellum samples tested there are no SNPs within the gene AC051649.6 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'AC051649.6' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1107 | Q11 | Are there any CAMLG SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Cerebellum, Basal Ganglia, Hippocampus, Cortex, Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain, Substantia nigra, Hypothalamus, Anterior Cingulate Cortex BA24, Whole Blood, Putamen Basal Ganglia, Amygdala, Whole Brain and Nucleus Accumbens Basal samples tested there are no SNPs within the gene CAMLG that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'CAMLG' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.832 | Q11 | Are there any BTG4 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene BTG4 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'BTG4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1498 | Q11 | Are there any TMEM99 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain and Liver samples tested there are no SNPs within the gene TMEM99 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'TMEM99' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.623 | Q11 | Are there any APP SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the APP gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs2830076
• Whole Blood: Adjusted SMR multi-SNP P-value: 3.19e-07; HEIDI: 5.2864e-05 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'APP' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1504767', 'Gene': 'APP', 'topRSID': 'rs2830076', 'p_SMR_multi': 3.194649e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 5.286428e-05}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.117 | Q11 | Are there any GALNT7 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Multi Ancestry Whole Brain and Substantia nigra samples tested there are no SNPs within the gene GALNT7 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'GALNT7' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.423 | Q11 | Are there any AC108488.3 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Frontal Cortex, Cerebellar Hemisphere, Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Hippocampus, Substantia nigra, Hypothalamus, Liver, Anterior Cingulate Cortex BA24, Putamen Basal Ganglia, Amygdala, Whole Brain, Whole Blood, Cerebellum and Nucleus Accumbens Basal samples tested there are no SNPs within the gene AC108488.3 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'AC108488.3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1911 | Q11 | Are there any RP11-889D3.1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene RP11-889D3.1 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'RP11-889D3.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.978 | Q11 | Are there any EEF1A1P6 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene EEF1A1P6 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'EEF1A1P6' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.611 | Q11 | Are there any SLC23A3 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Tibial Nerve and Whole Blood samples tested there are no SNPs within the gene SLC23A3 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'SLC23A3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1919 | Q11 | Are there any RP11-261P9.4 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Tibial Nerve and Whole Blood samples tested there are no SNPs within the gene RP11-261P9.4 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'RP11-261P9.4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.92 | Q11 | Are there any RP11-134D3.1 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood and Tibial Nerve samples tested there are no SNPs within the gene RP11-134D3.1 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'RP11-134D3.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.855 | Q11 | Are there any C10orf90 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood and Cortex samples tested there are no SNPs within the gene C10orf90 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'C10orf90' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1521 | Q11 | Are there any TAOK1 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Tibial Nerve samples tested there are no SNPs within the gene TAOK1 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'TAOK1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1918 | Q11 | Are there any CTPS SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene CTPS that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'CTPS' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.760 | Q11 | Are there any LRRC37A SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the LRRC37A gene has 7 SNPs that are statistically significant in Parkinson's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs566238830
• Prefrontal Cortex: Adjusted SMR multi-SNP P-value: 1.88e-15; HEIDI: 5.5367e-03
• rs62641967
• Whole Brain: Adjusted SMR multi-SNP P-value: 5.76e-15; HEIDI: 4.7220e-09
• rs3874943
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 5.88e-15; HEIDI: 6.9730e-08
• Tibial Nerve: Adjusted SMR multi-SNP P-value: 1.43e-11; HEIDI: 9.4368e-06
• Cerebellum: Adjusted SMR multi-SNP P-value: 8.21e-11; HEIDI: 2.0266e-06
• Cerebellar Hemisphere: Adjusted SMR multi-SNP P-value: 8.91e-11; HEIDI: 2.9617e-05
• Skeletal Muscle: Adjusted SMR multi-SNP P-value: 1.14e-09; HEIDI: 1.7772e-10
• Cortex: Adjusted SMR multi-SNP P-value: 3.90e-09; HEIDI: 2.9968e-05
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.07e-08; HEIDI: 7.0452e-07
• Frontal Cortex: Adjusted SMR multi-SNP P-value: 1.18e-08; HEIDI: 2.4963e-05
• Hypothalamus: Adjusted SMR multi-SNP P-value: 1.24e-08; HEIDI: 5.1999e-05
• Caudate Basal Ganglia: Adjusted SMR multi-SNP P-value: 2.09e-08; HEIDI: 4.8238e-07
• Nucleus Accumbens Basal: Adjusted SMR multi-SNP P-value: 5.67e-08; HEIDI: 1.2239e-08
• Hippocampus: Adjusted SMR multi-SNP P-value: 6.24e-08; HEIDI: 3.0075e-06
• Putamen Basal Ganglia: Adjusted SMR multi-SNP P-value: 1.70e-07; HEIDI: 1.9863e-09
• Substantia nigra: Adjusted SMR multi-SNP P-value: 3.86e-07; HEIDI: 4.7798e-04
• Amygdala: Adjusted SMR multi-SNP P-value: 8.27e-07; HEIDI: 1.4250e-04
• rs2696466
• Cortex: Adjusted SMR multi-SNP P-value: 1.76e-14; HEIDI: 3.9588e-11
• Basal Ganglia: Adjusted SMR multi-SNP P-value: 1.31e-09; HEIDI: 6.0723e-05
• Hippocampus: Adjusted SMR multi-SNP P-value: 1.75e-08; HEIDI: 7.1288e-05
• rs4510068
• Cerebellum: Adjusted SMR multi-SNP P-value: 1.71e-11; HEIDI: 3.2704e-07
• rs62055516
• Spinalcord: Adjusted SMR multi-SNP P-value: 1.66e-08; HEIDI: -9.9990e+03
• rs17698176
• Whole Blood: Adjusted SMR multi-SNP P-value: 9.68e-07; HEIDI: 5.9146e-05
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'LRRC37A' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1242281', 'Gene': 'LRRC37A', 'topRSID': 'rs566238830', 'p_SMR_multi': 1.879442e-15, 'Omic_tissue': 'Prefrontal Cortex', 'p_HEIDI': 0.005536709}, {'UUID': 'NDD_SMR_genes_all_update_text_1640226', 'Gene': 'LRRC37A', 'topRSID': 'rs62641967', 'p_SMR_multi': 5.760995e-15, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 4.722009e-09}, {'UUID': 'NDD_SMR_genes_all_update_text_1435919', 'Gene': 'LRRC37A', 'topRSID': 'rs3874943', 'p_SMR_multi': 5.879623e-15, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'p_HEIDI': 6.97304e-08}, {'UUID': 'NDD_SMR_genes_all_update_text_1147257', 'Gene': 'LRRC37A', 'topRSID': 'rs2696466', 'p_SMR_multi': 1.755785e-14, 'Omic_tissue': 'Cortex', 'p_HEIDI': 3.958793e-11}, {'UUID': 'NDD_SMR_genes_all_update_text_1328939', 'Gene': 'LRRC37A', 'topRSID': 'rs3874943', 'p_SMR_multi': 1.429027e-11, 'Omic_tissue': 'Tibial Nerve', 'p_HEIDI': 9.436828e-06}, {'UUID': 'NDD_SMR_genes_all_update_text_19648', 'Gene': 'LRRC37A', 'topRSID': 'rs4510068', 'p_SMR_multi': 1.713765e-11, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': 3.270415e-07}, {'UUID': 'NDD_SMR_genes_all_update_text_1710355', 'Gene': 'LRRC37A', 'topRSID': 'rs3874943', 'p_SMR_multi': 8.213472e-11, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': 2.026554e-06}, {'UUID': 'NDD_SMR_genes_all_update_text_1191177', 'Gene': 'LRRC37A', 'topRSID': 'rs3874943', 'p_SMR_multi': 8.908998e-11, 'Omic_tissue': 'Cerebellar Hemisphere', 'p_HEIDI': 2.961702e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_1370550', 'Gene': 'LRRC37A', 'topRSID': 'rs3874943', 'p_SMR_multi': 1.141873e-09, 'Omic_tissue': 'Skeletal Muscle', 'p_HEIDI': 1.777155e-10}, {'UUID': 'NDD_SMR_genes_all_update_text_27183', 'Gene': 'LRRC37A', 'topRSID': 'rs2696466', 'p_SMR_multi': 1.310623e-09, 'Omic_tissue': 'Basal Ganglia', 'p_HEIDI': 6.072306e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_1262230', 'Gene': 'LRRC37A', 'topRSID': 'rs3874943', 'p_SMR_multi': 3.901188e-09, 'Omic_tissue': 'Cortex', 'p_HEIDI': 2.996761e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_1679570', 'Gene': 'LRRC37A', 'topRSID': 'rs3874943', 'p_SMR_multi': 1.073486e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 7.045197e-07}, {'UUID': 'NDD_SMR_genes_all_update_text_1168840', 'Gene': 'LRRC37A', 'topRSID': 'rs3874943', 'p_SMR_multi': 1.177239e-08, 'Omic_tissue': 'Frontal Cortex', 'p_HEIDI': 2.496281e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_1462900', 'Gene': 'LRRC37A', 'topRSID': 'rs3874943', 'p_SMR_multi': 1.237554e-08, 'Omic_tissue': 'Hypothalamus', 'p_HEIDI': 5.199905e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_30029', 'Gene': 'LRRC37A', 'topRSID': 'rs62055516', 'p_SMR_multi': 1.664021e-08, 'Omic_tissue': 'Spinalcord', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_33015', 'Gene': 'LRRC37A', 'topRSID': 'rs2696466', 'p_SMR_multi': 1.74889e-08, 'Omic_tissue': 'Hippocampus', 'p_HEIDI': 7.12884e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_1281360', 'Gene': 'LRRC37A', 'topRSID': 'rs3874943', 'p_SMR_multi': 2.0939e-08, 'Omic_tissue': 'Caudate Basal Ganglia', 'p_HEIDI': 4.823831e-07}, {'UUID': 'NDD_SMR_genes_all_update_text_1730070', 'Gene': 'LRRC37A', 'topRSID': 'rs3874943', 'p_SMR_multi': 5.67403e-08, 'Omic_tissue': 'Nucleus Accumbens Basal', 'p_HEIDI': 1.223912e-08}, {'UUID': 'NDD_SMR_genes_all_update_text_1386995', 'Gene': 'LRRC37A', 'topRSID': 'rs3874943', 'p_SMR_multi': 6.237411e-08, 'Omic_tissue': 'Hippocampus', 'p_HEIDI': 3.007496e-06}, {'UUID': 'NDD_SMR_genes_all_update_text_1594929', 'Gene': 'LRRC37A', 'topRSID': 'rs3874943', 'p_SMR_multi': 1.697834e-07, 'Omic_tissue': 'Putamen Basal Ganglia', 'p_HEIDI': 1.986333e-09}, {'UUID': 'NDD_SMR_genes_all_update_text_1451666', 'Gene': 'LRRC37A', 'topRSID': 'rs3874943', 'p_SMR_multi': 3.857246e-07, 'Omic_tissue': 'Substantia nigra', 'p_HEIDI': 0.0004779751}, {'UUID': 'NDD_SMR_genes_all_update_text_1603780', 'Gene': 'LRRC37A', 'topRSID': 'rs3874943', 'p_SMR_multi': 8.273576e-07, 'Omic_tissue': 'Amygdala', 'p_HEIDI': 0.0001425027}, {'UUID': 'NDD_SMR_genes_all_update_text_1564789', 'Gene': 'LRRC37A', 'topRSID': 'rs17698176', 'p_SMR_multi': 9.67693e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 5.914575e-05}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.504 | Q11 | Are there any TMPRSS4 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene TMPRSS4 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'TMPRSS4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1287 | Q11 | Are there any RP11-703I16.1 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Tibial Nerve, Skeletal Muscle and Whole Blood samples tested there are no SNPs within the gene RP11-703I16.1 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'RP11-703I16.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1340 | Q11 | Are there any AC026954.6 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene AC026954.6 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'AC026954.6' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.12 | Q11 | Are there any TTC29 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood and Cortex samples tested there are no SNPs within the gene TTC29 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'TTC29' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.402 | Q11 | Are there any BLOC1S3 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Blood, Cortex, Prefrontal Cortex, Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain and Whole Brain samples tested there are no SNPs within the gene BLOC1S3 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'BLOC1S3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.288 | Q11 | Are there any AC006994.2 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene AC006994.2 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'AC006994.2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1075 | Q11 | Are there any MOBKL2B SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene MOBKL2B that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'MOBKL2B' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1201 | Q11 | Are there any HIST1H4D SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood and Prefrontal Cortex samples tested there are no SNPs within the gene HIST1H4D that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'HIST1H4D' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
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