0 stringlengths 12 494 | embeddings listlengths 384 384 |
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Treatment\tof\tthe\tprimary\tGI\tmanifestations\tappears\tto\tcorrect\tmost\tof\tthe\textraintestinal\tfeatures\tof\nthe\tdisease\tas\twell.\tThe\tmost\teffective\tmedical\tagents\tinclude\tcorticosteroids,\tantiinflammatory\nagents\t(aminosalicylates),\timmunosuppressive\tagents\t(cyclosporine,\tazathioprine,\n\tmerca... | [
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mercaptopurine),\nantibiotics\t(ciprofloxacin\tand\tmetronidazole),\tand\tmonoclonal\ttumor\tnecrosis\tfactor\tantagonists\n(anti-TNF),\tand\tinfliximab,\tadalimumab,\tcertolizumab,\tand\tnatalizumab,\tagents\tthat\tinactivate\tone\tof\nthe\tprimary\tinflammatory\tcytokines.\tAnti-TNF\thas\thistorically\tbeen\tused\tin... | [
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disease\tand\tfistulas,\tbut\tmore\trecently\tit\thas\tshown\tpromise\tin\tUC\tas\twell\t(\nMao\tet\tal,\t2017\n).\nInvestigations\tof\tvarious\ttreatment\tmodalities\tfor\tthe\tacute\tand\tchronic\tstages\tof\tIBD\tare\tongoing\nand\tinclude\tnew\tforms\tof\texisting\tdrugs\tas\twell\tas\tnew\tagents\ttargeted\tto\tre... | [
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activity\tof\tcytokines,\teicosanoids,\tor\tother\tmediators\tof\tthe\tinflammatory\tand\tacute-phase\tresponse\n(\nMonteleone\tet\tal,\t2014\n).\nSurgical\tmanagement\nIn\tCrohn’s\tdisease,\tsurgery\tmay\tbe\tnecessary\tto\n\trepair\tstrictures\t(narrowing\tof\tthe\tGI\tlumen)\tor\nremove\tportions\tof\tthe\tbowel\twh... | [
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with\tCrohn’s\tdisease\tundergo\tsurgery\trelated\tto\tthe\tdisease.\tSurgery\tdoes\tnot\tcure\tCrohn’s\tdisease,\nand\trecurrence\toften\toccurs\twithin\t1\tto\t3\tyears\tof\tsurgery.\tThe\tchance\tof\tneeding\tsubsequent\nsurgery\tin\tthe\tpatient’s\tlife\tis\tabout\t30%\tto\t70%,\tdepending\n\ton\tthe\ttype\tof\tsur... | [
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on\tthe\ttype\tof\tsurgery\tand\tthe\tage\tat\nthe\tfirst\toperation.\tMajor\tresections\tof\tthe\tintestine\tmay\tresult\tin\tvarying\tdegrees\tof\tmalabsorption\nof\tfluid\tand\tnutrients.\tIn\textreme\tcases\tpatients\tmay\thave\textensive\tor\tmultiple\tresections,\tresulting\nin\tshort-bowel\tsyndrome\t(SBS)\tand\... | [
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hydration\t(see\t\nChapter\t12\n).\nWith\tincreased\tefficacy\tof\tpharmaceutical\n\ttherapies\tfor\tUC,\tthe\tpercentage\tof\tpatients\twho\nundergo\ta\tcolectomy\tto\tremove\tthe\tcolon\tand\tresolve\tthe\tdisease\thas\tdecreased\tover\ttime\t(\nBarnes\tet\nal,\t2019\n).\tIf\tsurgery\tremains\tindicated,\tinflammatio... | [
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0.07893... |
Whether\ta\tcolectomy\tis\tnecessary\tdepends\ton\tthe\tseverity\tof\tthe\tdisease\tand\tindicators\tof\tincreased\ncancer\trisk.\tAfter\ta\tcolectomy\tfor\tUC,\tsurgeons\tmay\n\tcreate\tan\tileostomy\twith\tan\texternal\tcollection\npouch\tand\tan\tinternal\tabdominal\treservoir\tfashioned\twith\ta\tsegment\tof\tileum... | [
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which\tspares\tthe\trectum,\tto\tserve\tas\ta\treservoir\tfor\tstool.\tThe\tinternal\tKoch\tpouch\talso\tmay\tbe\tused\n(see\tlater\tin\tthis\tchapter\tfor\tmore\tdetailed\tdescription).\nMedical\tnutrition\ttherapy\nPersons\twith\tIBD\tare\tat\tincreased\trisk\tof\tnutrition\tproblems\n\tfor\ta\thost\tof\treasons\trel... | [
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for\ta\thost\tof\treasons\trelated\tto\tthe\ndisease\tand\tits\ttreatment.\tThus\tthe\tprimary\tgoal\tis\tto\trestore\tand\tmaintain\tthe\tnutrition\tstatus\tof\tthe\nindividual.\tFoods,\tdietary\tand\tmicronutrient\tsupplements,\tand\tenteral\tand\tparenteral\tnutrition\tmay\nbe\tused\tto\taccomplish\tthat\tmission.\t... | [
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during\tremissions\tand\texacerbations\tof\tthe\tdisease.\tDiet\tand\n\tspecific\tnutrients\tplay\ta\tsupportive\trole\nin\tmaintaining\tnutrition\tstatus\tand\tlimiting\tsymptom\texacerbations,\tas\twell\tas\tsupporting\tgrowth\tin\npediatric\tpatients.\nIn\tdaily\tlife\tpersons\twith\tIBD\tmay\thave\tintermittent\t“f... | [
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obstructions,\tnausea,\tabdominal\tpain,\tbloating,\tor\tdiarrhea.\tFoods\tthat\tare\tresponsible\tfor\tsome\tGI\nsymptoms\tin\ta\tnormal,\thealthy\tpopulation\n\t(gas,\tbloating,\tdiarrhea)\tare\tlikely\tto\tbe\ttriggers\tfor\tthe\nsame\tsymptoms\tin\tpatients\twith\tmild\tstages\tof\tIBD\tor\tthose\tin\tremission.\tM... | [
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individualized\tfood\tintolerances\t(\nHou\tet\tal,\t2014\n)\tand\tare\tsometimes\tadvised\tto\teliminate\tfoods\tthey\nsuspect\tare\tresponsible\tfor\tthe\tintolerance.\tOften,\tthe\tpatient\tbecomes\tincreasingly\tfrustrated\tas\tthe\ndiet\tbecomes\tprogressively\tlimited\tand\n\tsymptoms\tstill\tdo\tnot\tresolve.\tS... | [
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0.0383834... |
symptoms\tstill\tdo\tnot\tresolve.\tSince\tmalnutrition\tis\ta\nsignificant\trisk\tin\tpatients\twith\tIBD,\tan\toverly\trestrictive\tdiet\tonly\tincreases\tthe\tlikelihood\tof\nmalnutrition\tand\tweight\tloss.\nThere\tis\ta\tgreat\tdeficit\tof\tquality\tcontrolled\tdietary\tclinical\ttrials\tfor\tIBD.\tBecause\tof\tth... | [
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dietary\tregimen\tfor\treducing\tsymptoms\tor\tdecreasing\tflares\thas\tbeen\tfound\tto\tbe\tconclusively\neffective.\n\tThough\tlimited,\tcurrent\tdietary\tresearch\tis\texploring\tthe\tspecific\tcarbohydrate\tdiet,\nantiinflammatory\tdiet,\tlow\tFODMAPs\tdiet,\tand\tothers,\tand\tany\tpotential\tthey\tmay\thave\tto\t... | [
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patients\twith\tIBD\t(\nKakodkar\tet\tal,\t2015\n;\t\nOlendzki\tet\tal,\t2014\n;\t\nPrince\tet\tal,\t2016\n;\t\nBraly\tet\tal,\t2017\n;\nSuskind,\t2016\n).\tAn\timportant\taspect\tof\tdietary\tresearch\tis\tthe\timpact\tof\thow\tthe\tdiet\tacts\tas\tan\nenvironmental\tfactor\n\tthat\tcan\taffect\tthe\tmicrobiome\t(\nLe... | [
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0.07101... |
Lee\tet\tal,\t2015\n;\t\nNishida\tet\tal,\t2018\n).\tFar\tmore\ndietary\tresearch\tand\tclinical\ttrials\tare\tneeded\tto\tmake\tany\tspecific\tdietary\trecommendations\tfor\nIBD,\tbut\tthere\tis\tan\texciting\ttrend\tof\tinterest\tbrewing\tin\tthe\tscientific\tcommunity\t(\nLee\tet\tal,\t2016\n). | [
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Lee\tet\tal,\t2016\n).\nThe\tability\tof\tnutrition\tsupport\tas\teither\tPN\tor\tenteral\tnutrition\t(EN)\tto\tinduce\tremission\tof\tIBD\nhas\tbeen\tdebated\n\tfor\tseveral\tyears.\tEvaluation\tis\tconfounded\tby\tthe\tnatural\tcourse\tof\tIBD\twith\nexacerbations\tand\tremissions\tand\tby\tthe\tgenetic\tdiversity\to... | [
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0.02... |
corticosteroid\ttherapy\tto\tinduce\tremission\tin\tadults\twith\tCrohn’s\tdisease.\tFor\tchildren,\thowever,\tEN\nis\tfar\tmore\teffective\tthan\tthe\tplacebo\tand\tshould\tbe\tconsidered\tas\ta\tprimary\ttherapy.\tEN\tcan\talso\tbe\nused\tto\treverse\tmalnutrition\n\tthat\tcan\toccur\twith\tCrohn’s,\tand\tto\tencoura... | [
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0.0086... |
population\t(\nPalmer\tet\tal,\t2017\n).\tChildren\tcan\talso\tbenefit\tfrom\tEN,\teither\tas\tsole\tsource\tof\tnutrition\nor\tsupplemental\tto\tan\toral\tdiet,\tto\treduce\tdependence\ton\tsteroids\tthat\tmay\taffect\tgrowth\tand\tbone\ndisease.\tComplete\tbowel\trest\tusing\tPN\tis\tnot\tnecessarily\trequired\tbut\t... | [
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inadequate\tfunctioning\tbowel,\n\tor\tfor\t1\tto\t2\tweeks\tbefore\tsurgery\tin\tmalnourished\tpatients\t(\nPalmer\net\tal,\t2017\n).\tEN\thas\tthe\tpotential\tto\tfeed\tthe\tintestinal\tepithelium\tand\talter\tGI\tflora\tand\tis\tthe\npreferred\troute\tof\tnutrition\tsupport\tin\tpatients\twith\tadequate\tbowel\tleng... | [
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0.04339... |
elements\tof\tthe\tinflammatory\tprocess,\tserve\tas\ta\tvaluable\tsource\tof\tnutrients\tneeded\tfor\trestoration\nof\tGI\tdefects,\tand\tbe\tsteroid\tsparing\n\t(\nRichman\tand\tRhodes,\t2013\n).\tAvailable\tevidence\tdoes\tnot\nsupport\tthe\tuse\tof\tEN\tas\ta\tfirst-line\ttherapy\tin\tthose\twith\tUC,\tbut\ttoleran... | [
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... |
during\tacute\tflares\t(\nPalmer\tet\tal,\t2017\n).\nOverall,\tpatients\tand\tcaretakers\tmust\tbe\tvery\tcommitted\twhen\tusing\tEN\tformulas\tor\ttube\tfeeding\nbecause\tit\ttakes\t4\tto\t8\tweeks\tbefore\tone\tsees\tthe\tclinical\teffects.\tTimely\tnutritional\tsupport\tis\ta\tvital\ncomponent\tof\ttherapy\tto\trest... | [
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0.0... |
and\tabsorptive\tfunction\tby\tincreasing\tthe\tpermeability\tof\tthe\tGI\ttract\tto\tpotential\tinflammatory\nagents.\tEN\tis\talways\tthe\tpreferred\troute\tover\tPN\twhen\tnutrition\tsupport\tis\tmedically\tindicated\tin\nIBD.\tPN\tis\tnot\tas\tnutritionally\tcomplete,\thas\tincreased\trisk\tof\tinfectious\tcomplica... | [
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0.068600952... |
expensive\tthan\tEN.\tHowever,\tPN\tmay\tbe\trequired\tin\tpatients\twith\tpersistent\tbowel\tobstruction,\nfistulas,\tand\tmajor\tGI\tresections\tthat\tresult\tin\tSBS\twhere\tEN\tis\tnot\tpossible.\nEnergy\tneeds\tof\tpatients\twith\tIBD\tare\tnot\tincreased\t(unless\tweight\tgain\tis\tdesired).\tGenerally, | [
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0.05018885061144829,
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0.01773887127637863,
0.11564060300588608,
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0.0390... |
when\tdisease\tactivity\tincreases\tbasal\tmetabolic\trate,\tphysical\tactivity\tis\tgreatly\tcurtailed,\tand\noverall\tenergy\tneeds,\tare\tnot\n\tsubstantially\tchanged.\tProtein\trequirements\tmay\tbe\tincreased,\ndepending\ton\tthe\tseverity\tand\tstage\tof\tthe\tdisease\tand\tthe\trestoration\trequirements.\tInfla... | [
0.046188950538635254,
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0.0757075846195221,
-0.021055759862065315,
-0.10394591838121414,
0.03953952342271805,
0.12193479388952255,
0.0456603579223156,
0.006909482181072235,
0.058530863374471664,
0.07556004077196121,
-0.07587207853794098,
0.0070404913276433945,
0.0653258... |
and\ttreatment\twith\tcorticosteroids\tinduce\ta\tnegative\tnitrogen\tbalance\tand\tcause\ta\tloss\tof\tlean\nmuscle\tmass.\tProtein\tlosses\talso\toccur\tin\tareas\tof\tinflamed\tand\tulcerated\tintestinal\tmucosa\tvia\ndefects\tin\tepithelial\ttight\tjunctions\t(see\t\nChapter\t37\n).\tTo\tmaintain\tpositive\tnitroge... | [
0.02618550695478916,
-0.04629490524530411,
0.025437194854021072,
-0.015087755396962166,
-0.09429822117090225,
0.03634283319115639,
0.10268227756023407,
0.08426546305418015,
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0.09128837287425995,
0.10082939267158508,
-0.029117288067936897,
0.009299582801759243,
0.06366... |
1.5\tg/kg/day\tof\tprotein\tis\trecommended.\nSupplemental\tvitamins,\tespecially\tfolate,\tB\n6\n,\tand\tB\n12\n,\tmay\tbe\tneeded,\tas\twell\tas\tminerals\tsuch\tas | [
0.03437697887420654,
-0.020938435569405556,
0.04627487063407898,
-0.0023730220273137093,
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0.14130748808383942,
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0.03995584324002266,
0.0819377526640892,
-0.11927489936351776,
-0.018326718360185623,
-0.027... |
iron\tand\ttrace\telements\tto\treplace\tstores\tor\tfor\tmaintenance\tbecause\tof\tmaldigestion,\nmalabsorption,\tdrug-nutrient\tinteractions,\tor\tinadequate\tintake\t(\nOwczarek\tet\tal,\t2016\n).\tDiarrhea\tcan\naggravate\tlosses\tof\tzinc,\n\tpotassium,\tand\tselenium.\tPatients\twho\treceive\tintermittent\tcortic... | [
-0.035662971436977386,
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0.003112688660621643,
0.04555847495794296,
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0.09667641669511795,
0.06804883480072021,
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0.010199178010225296,
0.07743700593709946,
-0.008650335483253002,
0.029794232919812202,
0.0... |
may\tneed\tsupplemental\tcalcium\tand\tvitamin\tD.\tPatients\twith\tIBD\tare\tat\tincreased\trisk\tof\tosteopenia\nand\tosteoporosis;\t25-OH\tvitamin\tD\tlevels\tand\tbone\tdensity\tshould\tbe\tmonitored\troutinely\tand\nvitamin\tD\tsupplemented\tappropriately\t(\nHlavaty\tet\tal,\t2015\n).\tOmega-3\tfatty\tacid\tsuppl... | [
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0.07198193669319153,
0.002195599488914013,
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0.08888012170791626,
0.014074760489165783,
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0.0058587780222296715,
0.10158627480268478,
-0.023385990411043167,
0.021365385502576828,
-0... |
Crohn’s\tdisease\tsignificantly\treduce\n\tdisease\tactivity.\tUse\tof\tomega-3\tfatty\tacids\tor\tfish\toil\nsupplements\tin\tUC\tappears\tto\tresult\tin\ta\tsignificant\tmedication-sparing\teffect,\twith\treductions\tin\ndisease\tactivity\tand\tincreased\ttime\tin\tremission\treported\t(\nFarrukh\tand\tMayberry,\t201... | [
0.02203400619328022,
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0.0544523261487484,
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0.045085519552230835,
0.05574972555041313,
0.0008679704624228179,
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0.044285938143730164,
0.07982780039310455,
-0.06028708070516586,
-0.03590090572834015,
0.029056... |
Farrukh\tand\tMayberry,\t2014\n).\tUse\tof\nfoods\tand\tsupplements\tcontaining\tprebiotics\tand\tprobiotic\tsupplements\tcontinues\tto\tbe\tinvestigated\nfor\ttheir\tpotential\tto\talter\tthe\tgut\tmicrobiota;\n\tand\tfurther\tresearch\tis\tindicated\t(\nSinagra\tet\tal,\t2013\n;\nNishida\tet\tal,\t2018\n). | [
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0.0029618132393807173,
-0.03834405541419983,
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0.032295893877744675,
0.06906790286302567,
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0.019415438175201416,
0.1402699053287506,
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-0.008626656606793404,
... |
Sinagra\tet\tal,\t2013\n;\nNishida\tet\tal,\t2018\n).\nDuring\tacute\tand\tsevere\texacerbations\tof\tthe\tdisease,\tthe\tdiet\tis\ttailored\tto\tthe\tindividual\tbut\nusually\tincludes\treduced\tfiber\tintake\tand\tdecaffeinated,\tlow-sugar\tbeverages\tfor\tadequate\thydration\n(\nAcademy\tof\tNutrition\tand\tDietetic... | [
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0.007131990976631641,
0.059145309031009674,
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-0.06038409098982811,
0.02651262655854225,
0.11207672208547592,
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0.07192762196063995,
0.08098757266998291,
-0.04805110767483711,
0.03687131777405739,
-0.006... |
).\tIn\tpeople\twith\trapid\tintestinal\ttransit,\textensive\nbowel\tresections,\tor\n\textensive\tsmall\tbowel\tdisease,\tabsorption\tmay\tbe\tcompromised.\tHere,\texcessive\nintake\tof\tlactose,\tfructose,\tor\tsorbitol\tmay\tcontribute\tto\tabdominal\tcramping,\tgas,\tand\tdiarrhea;\tand | [
0.0433969683945179,
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0.04992168769240379,
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0.004051525145769119,
0.14484742283821106,
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0.004715318325906992,
0.060408614575862885,
0.0881151333451271,
-0.031698282808065414,
0.014164426364004612,
0.02091... |
high\tfat\tintake\tmay\tresult\tin\tsteatorrhea.\tHowever,\tthe\tincidence\tof\tlactose\tintolerance\tis\tno\tgreater\nin\tpatients\twith\tIBD\tthan\tin\tthe\tgeneral\tpopulation.\tPatients\twith\tIBD\twho\ttolerate\tlactose\tshould\nnot\tnecessarily\n\trestrict\tlactose-containing\tfoods\tbecause\tthey\tcan\tbe\ta\tva... | [
0.03370334580540657,
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0.05882978439331055,
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-0.1298995316028595,
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0.08671068400144577,
0.039660342037677765,
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0.021077901124954224,
0.101540207862854,
-0.014351901598274708,
0.03523293137550354,
0.017742816... |
quality\tprotein,\tcalcium,\tand\tvitamin\tD.\nPatients\twith\tstrictures\tor\tpartial\tbowel\tobstruction\tbenefit\tfrom\ta\treduction\tin\tdietary\tfiber\tor\nlimited\tfood\tparticle\tsize.\tSmall,\tfrequent\tfeedings\tmay\tbe\ttolerated\tbetter\tthan\tlarge\tmeals.\tSmall\namounts\tof\tisotonic\t(having\tthe\tsame\t... | [
0.010765100829303265,
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0.05150400847196579,
-0.03599299490451813,
-0.09879618883132935,
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0.0708756223320961,
0.014110876247286797,
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0.05789468064904213,
0.09902771562337875,
-0.030513359233736992,
0.0709332823753357,
0.01919... |
liquid\toral\tsupplements,\nmay\tbe\tvaluable\tin\trestoring\tintake\twithout\tprovoking\tsymptoms.\tIn\tcases\tin\twhich\tfat\nmalabsorption\tis\tlikely,\tsupplementation\twith\tfoods\tmade\twith\t\nmedium-chain\ttriglycerides\n(MCTs)\n\tmay\tbe\tuseful\tin\tadding\tcalories\tand\tserving\tas\ta\tvehicle\tfor\tfat-sol... | [
-0.021189305931329727,
-0.07527849823236465,
0.0709054097533226,
0.011977205984294415,
-0.015602457337081432,
0.015825705602765083,
0.09740395098924637,
0.060143571346998215,
-0.018799027428030968,
-0.0017238323343917727,
0.1212717667222023,
-0.0535895936191082,
0.023402521386742592,
0.001... |
be\tintroduced\tslowly\tto\tavoid\tGI\tdistress.\tHowever,\tthese\tproducts\tare\texpensive\tand\tmay\tbe\tless\neffective\tthan\tmore\tbasic\ttreatments.\nThe\tinformation\ton\tIBD\tavailble\tto\tthe\tgeneral\tpublic\tis\tsometimes\tinaccurate\tor\texaggerated,\tor\tit\nmay\tpertain\tonly\tto\tone\tindividual’s\tsitua... | [
-0.00007028361869743094,
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0.07897373288869858,
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0.008427604101598263,
0.07197889685630798,
-0.02035289630293846,
0.011785170994699001,
0.009548335336148739,
0.09787879884243011,
-0.024961652234196663,
0.04718702659010887,
0.0... |
education\tfor\tIBD\tpertains\tto\thelping\twith\tthe\tevaluation\tof\tnutrition\tinformation.\tPatients’\nparticipation\tin\tthe\tmanagement\tof\ttheir\tdisease\tmay\thelp\tto\treduce\n\tnot\tonly\tthe\tsymptoms\tof\tthe\ndisease\tbut\talso\tthe\tassociated\tanxiety\tlevel.\nMicrobiota.\nProbiotic\tfoods\tand\tsupplem... | [
0.04477056860923767,
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0.031827859580516815,
0.010654849000275135,
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0.06106668710708618,
0.027513111010193825,
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0.057630933821201324,
0.12108300626277924,
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0.04730087146162987,
0.0... |
because\tof\ttheir\tability\tto\tmodify\tthe\tgut\tmicrobiota\tand\tpotentially\tmodulate\tgut\tinflammatory\nresponse.\tMultistrain\tprobiotic\tsupplements\t(e.g.,\tVSL#3)\thave\tbeen\tshown\tto\tbe\tbeneficial\tin\nmaintaining\tdisease\n\tremission\tin\tpatients\twith\tUC\twho\thad\t\npouchitis\n,\tinflammation\tin\t... | [
0.011241651140153408,
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0.05441682040691376,
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0.040088411420583725,
0.07121746242046356,
0.0634336993098259,
0.036401864141225815,
0.08405508100986481,
0.006702857557684183,
0.03770213574171066,
0.063061... |
pouch\tsurgically\tformed\tafter\tcolectomy\t(\nShen\tet\tal,\t2014\n).\tSpecific\tprobiotic\tsupplements\tappear\tto\nbe\tuseful\tfor\tinduction\tand\textension\tof\tremissions\tin\tpediatric\tand\tadult\tUC\t(\nGhouri\tet\tal,\t2014\n;\nShen\tet\tal,\t2014\n).\nAlthough\tprobiotics\tappear\tuseful\tin\tUC,\tprobiotic... | [
-0.036214787513017654,
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0.03285650163888931,
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0.05523040145635605,
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0.010070268996059895,
0.14264461398124695,
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0.032564010471105576,
0.... |
improvement\n\tin\tCrohn’s\tdisease\tactivity\tin\tadults\tor\tpediatric\tpatients,\tnor\tdo\tprobiotic\tsupplements\nappear\tto\tprolong\tremission\tin\tCrohn’s\tdisease\t(\nGhouri\tet\tal,\t2014\n).\tDue\tto\tmany\tconfounding\nfactors\tto\tresearch\tincluding,\tbut\tnot\tlimited\tto,\tmedication\tuse\t(antibiotics,\... | [
-0.022618107497692108,
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0.06311537325382233,
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0.03192737698554993,
0.11493457108736038,
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0.05535966902971268,
0.026371629908680916,
0.04766831547021866,
0.06... |
antidiarrheals),\tvariability\tin\tprobiotic\tquality,\tand\tdifferences\tin\tdietary\tintake\tamong\tparticipants,\nit\thas\n\tyet\tto\tbe\testablished\twhether\tprobiotics\tcould\tbe\tof\tbenefit\tas\tpart\tof\tthe\troutine\ttreatment\tin\nIBD\t(\nAbraham\tand\tQuigley,\t2017\n).\nRegular\tintake\tof\tprebiotic\tfood... | [
-0.027752257883548737,
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0.031483422964811325,
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0.0453035943210125,
0.04682828113436699,
0.04787670075893402,
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0.03354189544916153,
0.11308890581130981,
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0.05985446274280548,
0.04829... |
starches\tcan\tbeneficially\taffect\tthe\tgut\tmicrobiota,\tfeeding\t\nLactobacillus\n\tand\t\nBifidobacteria\n,\tthus\nproviding\tcompetition\tto\tand\ttheoretically\tsuppression\tof\tpathogenic\tor\n\topportunistic\tmicrobiota.\tIn\naddition,\tfermentation\tof\tprebiotics\tleads\tto\tincreased\tproduction\tof\tSCFAs,... | [
-0.0015612044371664524,
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0.03687303885817528,
0.037891585379838943,
0.004786954261362553,
0.0028727613389492035,
0.1083841621875763,
0.11002505570650101,
-0.10243388265371323,
0.011594424955546856,
0.05... |
more\tacidic\tand\tless\tfavorable\tenvironment\tfor\topportunistic\tbacteria.\nUse\tof\tprobiotics\tand\tprebiotics\tmay\tprevent\tSIBO\tin\tpredisposed\tindividuals\tand\tmay\tbe\tused\tto\ntreat\tdiarrhea.\tAdditional\tstudy\tis\tneeded\tto\tidentify\tthe\tdose,\tthe\tmost\teffective\tprebiotic\tand | [
0.037628404796123505,
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0.04280295595526695,
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0.015293877571821213,
0.03083987347781658,
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0.06366407126188278,
0.13014551997184753,
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0.020817533135414124,
0.039... |
probiotic\tfoods,\tthe\tform\tin\twhich\tthey\tcan\tbe\tused\tfor\ttherapeutic\tand\tmaintenance\tpurposes,\tand\ntheir\trelative\tvalue\tcompared\twith\tother\ttherapies\t(\nGhouri\tet\tal,\t2014\n).\nMicroscopic\tcolitis\nInjury\tof\tthe\tcolon\tcaused\tby\tUC,\tCrohn’s\tdisease,\tinfections,\tradiation\tinjury,\tand... | [
-0.02676445245742798,
-0.05442096292972565,
0.02603563666343689,
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0.0015752949984744191,
0.09001437574625015,
0.023293038830161095,
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0.02422175370156765,
0.12114749103784561,
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0.06409776955842972,
0.0416... |
the\tcolon\tpresents\twith\tabnormalities\tsuch\tas\tedema,\tredness,\tbleeding,\tor\tulcerations\tthat\tare\nvisible\ton\tcolonoscopy\texamination.\tUnlike\tthe\tcolitis\tof\tIBD,\t\nmicroscopic\tcolitis\n\tis\tcharacterized\nby\tinflammation\tthat\tis\tnot\tvisible\tby\tinspection\tof\tthe\tcolon\tduring\tcolonoscopy... | [
-0.009786912240087986,
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0.07138090580701828,
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0.08828607201576233,
0.0136747807264328,
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0.01730445586144924,
0.048475828021764755,
0.010319977067410946,
0.028864676132798195,
0.066... |
when\tthe\tcolon’s\tlining\tis\tbiopsied\tand\tthen\texamined\tunder\ta\tmicroscope.\tPatients\twith\tmicroscopic\ncolitis\tcan\thave\tdiarrhea\tfor\tmonths\tor\tyears\tbefore\tthe\tdiagnosis\tis\tmade.\tThe\tcause\tof\tmicroscopic\ncolitis\tis\tunknown.\nPathophysiology\nThere\tare\ttwo\ttypes\tof\tmicroscopic\tcoliti... | [
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0.012206543236970901,
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0.07698670029640198,
0.06579908728599548,
0.026495687663555145,
0.011254632845520973,
0.05586502328515053,
0.010270446538925171,
0.04926826059818268,
0.07... |
lymphocytic\tcolitis\n,\tthere\tis\tan\taccumulation\tof\nlymphocytes\twithin\tthe\tlining\tof\tthe\tcolon.\tIn\t\ncollagenous\tcolitis\n,\tthere\tis\talso\ta\tlayer\tof\tcollagen\n(like\tscar\ttissue)\tjust\tbelow\tthe\tlining.\tSome\texperts\tbelieve\tthat\tlymphocytic\tcolitis\tand\tcollagenous\ncolitis\trepresent\t... | [
0.01493399403989315,
-0.0973975732922554,
0.008021797053515911,
-0.0331941694021225,
-0.08805840462446213,
0.04367675632238388,
0.06976567953824997,
0.06712391972541809,
-0.012747565284371376,
0.07964079082012177,
0.05611464008688927,
-0.010020812042057514,
0.03989090025424957,
0.099158748... |
colitis\trepresent\tdifferent\tstages\tof\tthe\tsame\tdisease.\n\tSymptoms\tinclude\tchronic,\twatery\tdiarrhea,\nmild\tabdominal\tcramps,\tand\tpain.\tMore\tthan\t30%\tof\tpatients\treport\tweight\tloss.\tMicroscopic\tcolitis | [
0.05982894450426102,
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0.0027389260940253735,
0.007154067512601614,
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0.026710761711001396,
0.0875183492898941,
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0.00019314544624648988,
0.026554573327302933,
0.011937310919165611,
0.021588178351521492,
0.1... |
appears\tmore\tfrequently\tin\tpatients\taged\t60\tto\t70\tyears,\tand\tcollagenous\tcolitis\toccurs\tmore\nfrequently\tin\tfemales\t(\nOhlsson,\t2015\n).\nMedical\tnutrition\ttherapy\nResearch\tis\tunderway\tto\tdetermine\tpossible\teffective\ttreatments\tfor\tmicroscopic\tcolitis,\tincluding | [
-0.006883425638079643,
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0.03197499364614487,
-0.02277272939682007,
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0.10372038185596466,
0.05989817902445793,
0.010673221200704575,
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0.10384418815374374,
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0.048716992139816284,
0.067... |
corticosteroids\tand\timmunosuppressive\tagents.\tMedical\tnutrition\ttherapy\tis\tsupportive\twith\tefforts\nto\tmaintain\tweight\tand\tnutrition\tstatus,\tavoid\tsymptom\texacerbation,\tand\tmaintain\thydration,\nsimilar\tto\tthat\tfor\tIBD.\nIrritable\tbowel\tsyndrome\nIrritable\tbowel\tsyndrome\t(IBS)\n\tis\ta\tfun... | [
0.044282589107751846,
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0.05607401207089424,
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-0.09491971880197525,
0.006875535473227501,
0.058665428310632706,
0.05230959504842758,
-0.049179479479789734,
0.05646812170743942,
0.08005775511264801,
0.008756688795983791,
0.001117964624427259,
0.02838... |
is\ta\tfunctional\tgastrointestinal\tdisorder\tdefined\tby\tthe\tAmerican\nCollege\tof\tGastroenterology\t(ACG)\tIBS\tTask\tForce\tas\t“abdominal\n\tdiscomfort\tassociated\twith\taltered\nbowel\thabits”\t(\nFord\tet\tal,\t2014\n).\tThe\t\nRome\tIV\tcriteria\n\tfor\tIBS\tand\tits\tsubtypes\tare\tused\tto\tdefine\nthe\td... | [
0.02128782868385315,
-0.07339485734701157,
0.035262253135442734,
-0.025165723636746407,
-0.08413010835647583,
-0.03024415299296379,
0.06430666893720627,
0.030486920848488808,
-0.0012808004394173622,
0.023193765431642532,
0.09144440293312073,
0.02022760920226574,
-0.019510947167873383,
0.08... |
the\tdiagnosis\tbased\ton\tthe\tpresence\tof\tGI\tsymptoms\t(\nBox\t27.10\n).\tIBS\tis\ta\tcondition\tcharacterized\tby\nunexplained\tabdominal\tdiscomfort\tor\tpain\tthat\tis\tassociated\twith\tchanges\tin\tbowel\thabits\n(\nSchoenfeld,\t2016\n).\tOther\tcommon\tsymptoms\tinclude\tgas,\tbloating,\tdiarrhea\n\tand\tcon... | [
0.042146530002355576,
-0.04771428182721138,
0.04647385701537132,
-0.016040168702602386,
-0.10352150350809097,
0.04991130530834198,
0.11359905451536179,
-0.001098460634239018,
-0.0007242269348353148,
0.028587467968463898,
0.07706433534622192,
-0.02043282799422741,
0.010383137501776218,
0.05... |
and\tconstipation,\tand\nincreased\tGI\tdistress\tassociated\twith\tpsychosocial\tdistress.\tThese\tsymptoms\tmay\tbe\tvague\tand\ntransient,\tmaking\tIBS\ta\tdiagnosis\tof\texclusion.\tIt\tis\tclassified\tas\ta\tfunctional\tdisorder\tbecause\ttests\nshow\tno\thistologic\tabnormalities\tand,\ttherefore,\tdiagnosis\tdep... | [
0.041681140661239624,
-0.05092209577560425,
0.05203695595264435,
-0.01238375622779131,
-0.10198254138231277,
-0.010156969539821148,
0.07672759890556335,
0.0017353238072246313,
-0.017473002895712852,
0.03701287880539894,
0.08959698677062988,
-0.0223830733448267,
0.05069594457745552,
0.02834... |
criteria\talso\tinclude\ta\trefining\tof\tsubtypes\tof\tIBS\tbased\ton\tpredominant\tstool\tpatterns\n\t(\nTable\t27.5\n).\nTABLE\t27.5\nSubtypes\tof\tIrritable\tBowel\tSyndrome\t(IBS)\tBased\ton\tStool\tPatterns\nType\nSymptoms\nIBS\twith\tpredominant\nconstipation\t(IBS-C)\nStool\ttype\t1\tand\t2\tmore\tthan\t25%\nSt... | [
-0.0060212742537260056,
-0.06248326599597931,
0.01242407038807869,
0.030411191284656525,
-0.08975351601839066,
0.043943509459495544,
0.044877789914608,
0.09317869693040848,
-0.024793092161417007,
0.006264215800911188,
0.04939395189285278,
-0.03947697579860687,
0.0030425749719142914,
0.0606... |
IBS\twith\tpredominant\tdiarrhea\n(IBS-D)\nStool\ttype\t1\tand\t2\tless\tthan\t25%\nStool\ttype\t6\tand\t7\tmore\tthan\t25%\nIBS\twith\tmixed\tbowel\thabits\t(IBS-\nM)\nStool\ttype\t1\tand\t2\tmore\n\tthan\t25%\nStool\ttype\t6\tand\t7\tmore\tthan\t25%\nUnsubtyped\tIBS\nMeet\tcriteria\tfor\tIBS\tbut\tbowel\thabits\tcann... | [
-0.02656763792037964,
-0.03715789318084717,
-0.0073309969156980515,
-0.021777808666229248,
-0.09854848682880402,
-0.014912073500454426,
0.09027976542711258,
0.011948422528803349,
-0.00262155057862401,
0.0416281595826149,
0.06589307636022568,
-0.03952393680810928,
0.048252400010824203,
0.05... |
IBS-C,\tD,\tor\tM\nData\tfrom\tLacy\tBE,\tet\tal.\tBowel\tDisorders,\t\nGastroenterology\n\t150:1393-1407,\t2016.\nBOX\t27.10\nRome\tIV\tCriteria\tfor\tDiagnosing\tIrritable\tBowel\tSyndrome\n(IBS)\nRome\tIV\tcriteria\tfor\tdiagnosing\tIBS\n*\n:\nRecurrent\tabdominal\tpain,\ton\taverage,\tat\tleast\t1\n\tday/week\tin\t... | [
0.04956196993589401,
-0.0440816804766655,
0.030486606061458588,
-0.004063514061272144,
-0.1390608847141266,
0.009113738313317299,
0.017251640558242798,
0.003947938326746225,
-0.0326533243060112,
-0.03125499561429024,
0.05796625837683678,
-0.08574318885803223,
0.0061989277601242065,
0.04424... |
two\tor\tmore\tof\tthe\tfollowing\tcriteria:\n•\t\nRelated\tto\tdefecation\n•\t\nAssociated\twith\ta\tchange\tin\tfrequency\tof\tstool\n•\t\nAssociated\twith\ta\tchange\tin\tform\t(appearance)\tof\tstool\n*Criteria\tfulfilled\tfor\tthe\tlast\t3\tmonths\twith\tsymptom\tonset\tat\tleast\t6\tmonths\tbefore\tdiagnosis.\t\n... | [
0.025046568363904953,
-0.052773360162973404,
0.08548488467931747,
-0.016864748671650887,
-0.13043223321437836,
-0.02358722686767578,
0.04517967626452446,
-0.0005377394263632596,
-0.014039215631783009,
0.027171332389116287,
0.08963234722614288,
-0.05790700763463974,
0.05982663482427597,
0.0... |
Data\tfrom:\tLacy\tBE,\tet\tal.\tBowel\tDisorders.\t\nGastroenterology\n.\t2016;150:1393-1407;\n\tRome\tIII\tDiagnostic\nCriteria\tfor\tFunctional\tGastrointestinal\tDisorders.\nhttp://www.romecriteria.org/assets/pdf/19_RomeIII_apA_885-898.pdf\n;\nhttps://irritablebowelsyndrome.net/clinical/new-rome-iv-diagnostic-crite... | [
0.019104275852441788,
-0.04408639669418335,
0.021977480500936508,
-0.0048524243757128716,
-0.13780376315116882,
-0.04422318935394287,
-0.024236764758825302,
0.1365131139755249,
-0.04075287654995918,
-0.020266227424144745,
0.07294848561286926,
-0.03062732331454754,
-0.047596827149391174,
0.... |
.\nResearch\tis\tunderway\tto\tbetter\tdefine\tIBS,\twhich\tmay\tbe\treflected\tin\ta\tnew\tname\tfor\tthis\nchallenging\tdisease\tprocess.\nAn\testimated\t10%\tto\t20%\tof\tthe\tUnited\tStates\tpopulation\n\thas\tIBS,\twith\ttwice\tas\tmany\twomen\tas\nmen\tbeing\taffected,\talthough\tthis\tmay\tbe\ta\tfactor\tof\trep... | [
0.011948985047638416,
-0.05671167001128197,
0.030608009546995163,
-0.06314791738986969,
-0.08709056675434113,
0.02787167951464653,
0.07152250409126282,
-0.004597477614879608,
-0.016811247915029526,
0.09446285665035248,
0.08223490417003632,
-0.017988454550504684,
0.07364624738693237,
0.0082... |
Koff\tand\tMullin,\t2012\n).\tThere\tare\nbetween\t2.4\tand\t3.5\tmillion\tannual\tphysician\tvisits\tfor\tIBS\tin\tthe\tUnited\tStates\talone.\tIBS\tis\tthe\nmost\tcommon\tdisorder\tdiagnosed\tby\tgastroenterologists\tand\taccounts\tfor\t20%\tto\t40%\tof\tvisits\n(\nInternational\tFoundation\tfor\tFunctional\tGastroin... | [
0.01748628541827202,
-0.026050932705402374,
0.0444907583296299,
-0.0164338406175375,
-0.07999736070632935,
-0.016662955284118652,
0.09814108908176422,
0.04382644221186638,
-0.02239808440208435,
-0.011912443675100803,
0.07654628157615662,
-0.027511321008205414,
0.009983347728848457,
0.04237... |
).\tPatients\twith\nIBS\toften\tmiss\tschool\tand\twork\tdays,\tresulting\tin\tdecreased\tproductivity,\tincreased\thealth\tcare\ncosts,\tand\tdecreased\tquality\tof\tlife\tas\ta\tresult\tof\ttheir\tsymptoms.\nEtiology\nNo\tspecific\tmarker\tor\ttest\tis\tdiagnostic\tfor\tIBS.\tLactulose\tbreath\ttesting\thas\tbeen\tus... | [
0.05413214862346649,
-0.05280187353491783,
0.019861914217472076,
-0.01688820868730545,
-0.1147855743765831,
0.0054459767416119576,
0.08056464791297913,
0.02493571676313877,
-0.0024318944197148085,
0.047928810119628906,
0.09215330332517624,
-0.011723806150257587,
0.03277349844574928,
0.0730... |
breath\thydrogen\tand\tmethane\tlevels\tresulting\tfrom\tan\tovergrowth\tof\tbacteria\tin\tthe\tsmall\tintestine,\nand\n\tthis\thas\tbeen\tcorrelated\twith\tsome\tcases\tof\tIBS\t(\nRezaie\tet\tal,\t2017\n).\tWhen\tassessing\ta\tpatient\nfor\tIBS,\tthe\tclinician\tmust\tcarefully\treview\tmedication\trecords\tbecause\t... | [
-0.026892639696598053,
0.0034145989920943975,
0.059774357825517654,
-0.05904962867498398,
-0.09240790456533432,
0.00749640166759491,
0.08246900141239166,
-0.019970998167991638,
0.002389160916209221,
0.03358113765716553,
0.10318517684936523,
-0.03898441046476364,
0.040230415761470795,
0.042... |
and\tprescribed\tmedications\tcan\tcause\tabdominal\tsymptoms\tsuch\tas\tpain\tand\tchanges\tin\tbowel\nhabits.\tIn\taddition,\tthe\tsymptoms\tof\tIBS\toverlap\twith\tor\tare\tsimilar\tto\tother\tGI\tdiseases\tsuch\tas\tCD,\nIBD,\tfunctional\n\tdyspepsia,\tand\tfunctional\tconstipation.\tIBS\tmay\tbe\tpresent\twith\tCD... | [
0.004671359434723854,
-0.0693020299077034,
0.0653778612613678,
-0.040559131652116776,
-0.0963532030582428,
-0.0042016287334263325,
0.10782641172409058,
0.027714507654309273,
0.00743696466088295,
0.050545625388622284,
0.07671184837818146,
-0.01775490678846836,
0.042148273438215256,
0.051005... |
bleeding,\tiron\tdeficiency\tanemia,\tunintentional\tweight\tloss,\tand\tfamily\thistory\tshould\talso\tbe\nconsidered\twhen\tassessing\tsymptoms\tas\tthey\tare\tnot\tcommon\tfor\tpatients\twith\tIBS\t(\nIreton-Jones,\n2017\n;\t\nChey\tet\tal,\t2015\n).\nPathophysiology\nThe\tpathophysiology\tof\tIBS\tis\tnot\tcomplete... | [
-0.023585079237818718,
-0.027040917426347733,
0.02405383065342903,
0.007505415938794613,
-0.0635276660323143,
0.012177539989352226,
0.06383953988552094,
0.0675695613026619,
-0.013900588266551495,
0.04410377889871597,
0.028924182057380676,
-0.013139339163899422,
-0.0426432229578495,
0.06164... |
to\tplay\ta\nrole\tin\tthe\tetiology\tof\tIBS,\tincluding\tnervous\tsystem\talterations\t(abnormal\tGI\tmotility\tand\tvisceral\nhypersensitivity),\tgut\tflora\talterations,\tgenetics,\tand\tpsychosocial\tstress\t(\nChey\tet\tal,\t2015\n).\tResearch\ntraditionally\thas\tfocused\ton\tintestinal\tmotility;\thowever,\tstu... | [
0.028814444318413734,
-0.0783444344997406,
0.0646337941288948,
-0.002613345393911004,
-0.11369631439447403,
0.0047354609705507755,
0.09370770305395126,
0.024202963337302208,
0.01265717949718237,
0.04618678614497185,
0.11025457084178925,
-0.014140353538095951,
0.019176680594682693,
0.064153... |
show\tinconsistent\tresults\twith\tchanges\tin\tthe\tintestinal\tmicrobiome\tplaying\ta\n\tlarge\trole\tin\tthe\ndevelopment\tof\tIBS\t(\nDupont,\t2014\n).\nSensation\tin\tthe\tGI\ttract\tresults\tfrom\tstimulation\tof\tvarious\treceptors\tand\tsensory\tnerves\tin\tthe\ngut\twall,\twhich\ttransmit\tsignals\tto\tthe\tsp... | [
0.03274109587073326,
-0.044900473207235336,
0.05400148779153824,
-0.0802358090877533,
-0.09667312353849411,
0.04348263889551163,
0.0811818465590477,
-0.0006708194850943983,
0.004323157016187906,
0.06831427663564682,
0.10000753402709961,
-0.05195148289203644,
0.0530097633600235,
0.057249657... |
involved\tin\tpain\tmodulation,\tautonomic\tnervous\tsystem\tdysregulation,\tand\timpaired\tbrain-gut\ncommunication\tresult\tin\thyperalgesia\t(increased\tsensation\n\tto\tpain\tin\tthe\tgut),\tvisceral\nhypersensitivity,\tand\taltered\tmotility\t(\nChey\tet\tal,\t2015\n;\t\nAnastasi\tet\tal,\t2013\n).\tDysregulation\... | [
0.0124032748863101,
-0.0705450177192688,
0.019178319722414017,
-0.006308430340141058,
-0.09195391833782196,
0.03778897970914841,
0.04012264683842659,
0.04648841172456741,
0.01826067827641964,
0.053685691207647324,
0.09404437988996506,
-0.022768856957554817,
0.0136664267629385,
0.0630770027... |
Chey\tet\tal,\t2015\n;\t\nAnastasi\tet\tal,\t2013\n).\tDysregulation\tof\nserotonin\tconcentrations\tin\tthe\tGI\ttract\thas\tbeen\tcorrelated\twith\tthe\ttype\tof\tIBS\ta\tpatient\nexperiences;\tlow\tserotonin\tconcentrations\tare\tassociated\twith\tconstipation\tor\ta\tsluggish\tgut\tand\nhigher\tserotonin\tconcentra... | [
0.006651873234659433,
-0.06651481986045837,
0.018751826137304306,
-0.013383971527218819,
-0.08961106091737747,
-0.004806543234735727,
0.09687539935112,
0.028135448694229126,
-0.003606344573199749,
0.0139226745814085,
0.09423506259918213,
-0.02578800544142723,
0.045177336782217026,
0.038078... |
in\tthe\tintestine\n(\nKanazawa\tet\tal,\t2011\n;\t\nStasi\tet\tal,\t2014\n).\nOften\tSIBO\tis\tseen\twith\tIBS;\thowever,\tadditional\tstudies\tare\tneeded\tto\tunderstand\twhether\tSIBO\nis\tdirectly\tconnected\tto\tIBS\tor\tis\ta\tseparate\tentity.\tAlthough\ttreatment\tof\tSIBO\tusually\tincludes\nantibiotic\tand\t... | [
-0.015258053317666054,
-0.02825881354510784,
0.05027978494763374,
-0.04622975364327431,
-0.09240268170833588,
-0.0003011433582287282,
0.09595372527837753,
-0.018055321648716927,
0.007926888763904572,
0.059146516025066376,
0.08860819041728973,
-0.002473961329087615,
0.08694547414779663,
0.0... |
Psychological\tconditions,\tsuch\tas\tdepression\tand\tanxiety,\n\toften\tare\tobserved\tin\tpatients\twith\tIBS.\nAlthough\tit\tis\tunclear\twhether\tstress\tis\ta\tcause\tof\tIBS,\tit\tis\tknown\tto\ttrigger\tand\texacerbate\nsymptoms\t(\nStaudacher,\t2017\n).\tIt\tis\tnot\tunusual\tfor\tpatients\twith\tIBS\tto\tlink... | [
0.013712427578866482,
0.005365183111280203,
0.05996374040842056,
0.02489970251917839,
-0.03297528252005577,
0.033321112394332886,
0.07829183340072632,
0.021440671756863594,
0.024784574285149574,
0.00903585460036993,
0.10567667335271835,
0.011910374276340008,
0.04365561157464981,
0.04794272... |
lifetime\tor\tdaily\tstress\t(\nFadgyas-Stanculete\tet\tal,\t2014\n).\nMedical\tmanagement\nThe\tfirst\tstep\tin\tthe\tmanagement\tof\tIBS\tand\tother\tfunctional\tGI\tdisorders\tincludes\n\tvalidating\tthe\nreality\tof\tthe\tpatient’s\tcomplaints\tand\testablishing\tan\teffective\tclinician-patient\trelationship.\tCar... | [
-0.03297317400574684,
0.0036174259148538113,
0.06607992202043533,
0.012460914440453053,
-0.08787275105714798,
0.030202778056263924,
0.09247361868619919,
0.02100079134106636,
0.011555350385606289,
0.007869606837630272,
0.10102342814207077,
-0.009833939373493195,
0.03996800631284714,
0.02367... |
should\tbe\ttailored\tto\thelp\tthe\tpatient\tmanage\tthe\tsymptoms\tand\tthe\tfactors\tthat\tmay\ttrigger\tthem.\nNutrition\ttherapy\tusing\tthe\tFODMAP\telimination\tdiet\tshould\tbe\ta\tprimary\tconsideration\tfor\tIBS.\nGibson\tnoted\tthat\tthe\thigh\tquality\tof\tevidence\tfor\tthe\tFODMAP\telimination\tdiet\tsupp... | [
-0.01167844794690609,
-0.021020222455263138,
0.043416377156972885,
-0.0624450147151947,
-0.09291478246450424,
-0.012557195499539375,
0.05751316249370575,
0.01238970272243023,
-0.026033470407128334,
0.03308555483818054,
0.10133174061775208,
0.001526507898233831,
0.06323803961277008,
0.04987... |
its\tuse\tas\nfirst-line\ttherapy\t(\nGibson,\t2017b\n).\tDrug\ttherapy\tis\taimed\tat\tmanagement\tof\tsymptoms\tassociated\nwith\tGI\tmotility,\tvisceral\thypersensitivity,\tor\tpsychological\tissues.\tCombination\therbal\tremedies\tmay\nbe\temployed\tas\twell\tand\thave\tbeen\tfound\tto\tbe\tas\teffective\tas\tantib... | [
0.01907172054052353,
-0.05781657621264458,
0.03407495096325874,
-0.03833342343568802,
-0.09418948739767075,
0.03148933872580528,
0.04380094259977341,
0.0363507941365242,
-0.0028834594413638115,
0.06318480521440506,
0.08947819471359253,
-0.012823199853301048,
0.038726773113012314,
0.0504496... |
Mullin\tet\tal,\n2014\n).\tThe\ttreatment\toption\tis\tusually\tdetermined\tby\tthe\tpredominant\tbowel\tpattern\tand\tthe\nsymptoms\tthat\tmost\tdisrupt\tthe\tpatient’s\tquality\tof\tlife\t(\nTable\t27.6\n).\nTABLE\t27.6\nMedical\tand\tHerbal\tTreatment\tOptions\tfor\tIrritable\tBowel\tSyndrome\t(IBS)\tSymptoms\nSympt... | [
-0.007012801710516214,
-0.04194153472781181,
0.07355541735887527,
-0.028865674510598183,
-0.08436640352010727,
0.0014769668923690915,
0.06835102289915085,
0.09835565090179443,
-0.0023426765110343695,
-0.017891578376293182,
0.06362787634134293,
0.034363530576229095,
0.005110418424010277,
0.... |
Symptom\nTreatment\nAbdominal\tpain\tand\ndiscomfort\nAntispasmodic\tagents\nTricyclic\tantidepressants\nSerotonin-directed\tagents\t(selective\tserotonin\treuptake\tinhibitors,\nserotonin-3\treceptor\tantagonists,\tor\tserotonin-4\treceptor\n\tagonists)\nDigestive\tenzymes\nPeppermint\toil\nMelatonin\nConstipation\nFi... | [
0.0350332073867321,
-0.08985967189073563,
0.019720135256648064,
0.017241451889276505,
-0.03654245287179947,
0.041639216244220734,
0.12337473034858704,
0.07389678806066513,
-0.0014466370921581984,
0.04652061313390732,
0.07660212367773056,
-0.04022195562720299,
0.004172057379037142,
0.069896... |
Fiber\tsupplements:\tpsyllium\thusk,\tsoluble,\tnonfermentable\nStool\tsofteners\nLaxatives\t(osmotic,\ti.e.,\tMg;\tstimulant,\ti.e.,\tsenna)\nDiarrhea\nAntidiarrheal\tagents\t(loperamide,\tdiphenoxylate\twith\tatropine)\nSoluble\tfiber\tsupplements\nSmall\tintestinal\tbacterial\novergrowth\t(SIBO)\nAntibiotics\nHerbal... | [
-0.04148106276988983,
-0.13183994591236115,
0.020145751535892487,
0.017085518687963486,
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0.01924055814743042,
0.0740283653140068,
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0.02353493683040142,
0.14792367815971375,
0.003573009744286537,
-0.019105395302176476,
0.08908... |
Antibiotics\nHerbal\ttreatments\tincluding\tberberine\n\tand\toregano\nElemental\tdiet\t(2-week\ttherapy)\nDigestive\tenzymes\nGlobal\tsymptoms\tand/or\noverall\twell-being\nPsychotherapy\t(cognitive\tbehavioral\ttherapy,\trelaxation\ttherapy,\tgut-directed\nhypnotherapy)\nComplementary\tand\tintegrative\tmedicine\t(ac... | [
0.03082018531858921,
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0.04409782961010933,
0.031516801565885544,
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0.01798602193593979,
0.030742652714252472,
0.0844988077878952,
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0.008551825769245625,
0.03392922878265381,
0.022641116753220558,
0.008093235082924366,
0.08046949... |
reduction)\nProbiotics\nPrebiotics\t(use\twith\tcaution\tif\tbloating\tis\tpresent)\nData\tfrom\tChey\tW,\tKurlander\tJ,\tEswaran\tS:\n\tIrritable\tbowel\tsyndrome:\ta\tclinical\treview,\t\nJAMA\n\t313(9):949–958,\t2015;\tMullin\tG,\tShepherd\tSJ,\nRoland\tCB,\tet\tal:\tIrritable\tbowel\tsyndrome:\tcontemporary\tnutrit... | [
0.020255429670214653,
0.036824632436037064,
0.08873284608125687,
-0.04862070456147194,
-0.06845227628946304,
0.004250968806445599,
0.022499827668070793,
0.0403730534017086,
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0.06889751553535461,
0.07506716251373291,
0.0005431684548966587,
0.03967000171542168,
0.077762... |
JPEN\tJ\tParenter\tEnteral\tNutr\n\t38(7):781–799,\t2014. | [
-0.018720153719186783,
0.04439196363091469,
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0.024315500631928444,
0... |
Medical\tnutrition\ttherapy\nThe\tgoals\tof\tnutrition\ttherapy\tfor\tIBS\tare\tto\tensure\tadequate\tnutrient\tintake\tand\texplain\tthe\npotential\troles\tof\tfoods\tin\tthe\tmanagement\n\tof\tsymptoms.\tFirst-line\ttherapy\tto\ttreat\tIBS\tis\tthe\nimplementation\tof\tthe\tFODMAP\telimination\tdiet\tor\tlow\tFOODMAP... | [
-0.015266417525708675,
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0.03198898211121559,
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0.036873482167720795,
0.10318093746900558,
-0.007584179751574993,
0.04668276011943817,
0.033... |
chapter.\tBecause\tthe\tsymptoms\tmay\thave\tbeen\tongoing\tfor\ta\tperiod\tof\ttime,\ta\tthorough\tnutrition\nassessment\tshould\tbe\tcompleted\tinitially.\tThis\tshould\tinclude\t(1)\tassessment\tof\tnutritional\tstatus-\nbody\tweight\tstatus,\tloss\tor\tgain,\tand\tfood\tintake;\n\t(2)\treview\tof\tcurrent\tmedicati... | [
0.014430852606892586,
0.007014835253357887,
0.05806345120072365,
-0.035245854407548904,
-0.06639095395803452,
0.03647203370928764,
0.0658201202750206,
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0.06231871619820595,
0.10120287537574768,
-0.01708812266588211,
0.0728834718465805,
-0.018065... |
(2)\treview\tof\tcurrent\tmedications\tfor\tIBS\tand\tother\nmedications;\t(3)\treview\tof\tGI\tsymptoms\t(duration,\tseverity,\tfrequency);\t(4)\treview\tof\tsupplement\nintake\t(vitamins,\tminerals,\tfats,\tpre-\tand\tprobiotics,\therbals);\tand\t(5)\treview\tof\tuse\tof\tmind-body\ntherapies\tand\tthe\tresults\tachi... | [
0.002112869406118989,
-0.06965678185224533,
0.03659447655081749,
-0.04297669976949692,
-0.06017797440290451,
0.02587139420211315,
0.08019951730966568,
0.023454157635569572,
0.0017360018100589514,
0.03603494539856911,
0.09816189110279083,
-0.035344526171684265,
0.011431187391281128,
0.01117... |
Ireton-Jones,\t2017\n;\t\nMullin\tet\tal,\t2014\n).\tPresence\tof\tCD\tshould\tbe\nruled\tout\tas\twell\tas\tany\tdisease\tassociated\twith\n\tsymptoms\tsuch\tas\tdelayed\tgastric\temptying\tor\nbleeding,\twhich\tare\tnot\tkey\tsigns\tof\tIBS.\nThe\tFODMAPs\telimination\tdiet\nA\tdiet\tlow\tin\t\nf\nermentable\t\no\nli... | [
-0.030833952128887177,
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0.0033463917206972837,
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0.1224408820271492,
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0.07041699439287186,
0.09347685426473618,
-0.013503765687346458,
0.051748085767030716,
0.... |
d\ni,\t&\t\nm\nonosaccharides\tand\t\np\nolyols\t(FODMAP)\thas\tbeen\tshown\tto\tbe\nan\teffective\ttherapy\tin\tthe\tmanagement\tof\tGI\tsymptoms\tin\tpatients\twith\tIBS.\tFODMAPs\tare\tmade\tup\nof\tthe\tfermentable\tcarbohydrate\tportion\tof\tplant\tbased\tfoods.\tWhen\tmetabolized\tby\n\tgut\tbacteria,\nFODMAPs\ti... | [
-0.04159458726644516,
-0.03258195146918297,
0.030449209734797478,
0.0018246595282107592,
-0.06214921176433563,
0.01037251390516758,
0.07147889584302902,
0.03775729238986969,
0.002470749896019697,
0.04992391914129257,
0.1350812017917633,
-0.015939079225063324,
0.03247929364442825,
0.0445829... |
Ireton-Jones,\t2017\n;\t\nChey\tet\nal,\t2015\n;\t\nMullin,\t2014\n;\t\nShepherd\tand\tGibson,\t2006\n).\tIn\taddition,\tthese\tfoods\tincrease\tluminal\twater\ncontent\tand\tfluid\tstatus\tin\tthe\tGI\ttract.\tWhen\tthese\tare\tlimited\tor\teliminated,\tsymptoms\tare\talso\nreduced\tor\teliminated\tin\tup\tto\t70%\tof... | [
-0.03249543160200119,
0.0014362663496285677,
0.006667332258075476,
-0.03252864256501198,
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-0.028283948078751564,
0.10365781933069229,
-0.0016361793968826532,
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0.03497439995408058,
0.12947548925876617,
-0.04754801094532013,
0.050418220460414886,
0... |
Gibson,\t2017a\n).\tThis\thas\tbeen\tdemonstrated\nin\tchildren\tas\twell\t(\nChumpitazi\tet\tal,\t2015\n).\nThe\tlow\t\nFODMAPs\n\tdiet\tlimits\tfoods\tthat\tcontain\tlactose,\tfructose,\tfructo-oligosaccharides\n(fructans),\tgalacto-oligosaccharides\t(galactans),\tand\tpolyols\tor\tsugar\talcohols\t(sorbitol,\txylito... | [
-0.03371205925941467,
-0.061048880219459534,
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0.002382214879617095,
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0.041411884129047394,
0.05230081081390381,
0.023344382643699646,
0.034933172166347504,
0.02654404193162918,
0.13296405971050262,
-0.05707285925745964,
-0.025205548852682114,
0.01... |
mannitol,\tisomaltase,\tand\tmaltitol).\tThese\tshort-chain\tcarbohydrates\tare\tpoorly\tabsorbed\tin\tthe\nsmall\tintestine,\tare\thighly\tosmotic,\tand\tare\trapidly\tfermented\n\tby\tbacteria\tin\tthe\tsmall\tand\tlarge\nintestine,\tresulting\tin\tgas,\tpain,\tand\tdiarrhea\tin\tsensitive\tindividuals.\tFODMAPs\thav... | [
0.035155054181814194,
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0.06658533960580826,
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0.07694905996322632,
0.003853597678244114,
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0.08964481204748154,
0.08560876548290253,
-0.044231705367565155,
0.012631353922188282,
0.0... |
impact\ton\tGI\tsymptoms.\tA\tthreshhold\tlevel\tfor\tacceptable\tamounts\tof\tFODMAPs\thas\tnot\tbeen\twell\ndefined\tand\tis\tlikely\tpatient\tspecific.\tPatients\tmay\ttolerate\tsmall\tamounts,\tbut\tsymptoms\tcan\tdevelop\nif\tthey\tconsume\tquantities\tthat\tsurpass\ttheir\tthreshold.\tLactulose\tbreath\n\ttesting... | [
0.06119643896818161,
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0.05226609483361244,
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-0.0946931466460228,
0.02735336683690548,
0.07003758102655411,
0.05337914824485779,
0.025741098448634148,
0.009619398973882198,
0.13667283952236176,
0.028982220217585564,
0.031263213604688644,
0.0471165... |
testing,\tordered\tby\ta\nphysician,\tcan\tbe\tuseful\tto\tdemonstrate\tthe\tpresence\tof\tSIBO\tby\tmeasuring\tincreases\tin\tbreath\nhydrogen\tand\tmethane\t(\nRezaie\tet\tal,\t2017\n).\tThese\tgases\tare\tincreased\twhen\tgut\tbacteria\tmetabolize\nFODMAPs,\tespecially\tin\tthe\tsmall\tintestine. | [
-0.012291652150452137,
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0.04412830248475075,
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0.07360081374645233,
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0.07620124518871307,
0.13176970183849335,
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0.... |
FODMAPs,\tespecially\tin\tthe\tsmall\tintestine.\nNutrition\tintervention\tbegins\twith\telimination\tof\tall\thigh\tFODMAPs\tfoods\tfrom\tthe\tdiet\tfor\ta\ttrial\nperiod\tof\tapproximately\t6\tweeks\talthough\n\tsymptoms\tmay\timprove\twithin\t2\tweeks\t(\nIreton-Jones,\n2017\n;\t\nBarrett,\t2017\n;\t\nCatsos,\t2017\... | [
0.011119339615106583,
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0.03765304759144783,
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0.008023704402148724,
0.057112932205200195,
0.021922312676906586,
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0.06423234194517136,
0.08895168453454971,
-0.045938640832901,
0.04407138004899025,
-0.01050... |
;\t\nGibson,\t2011\n).\tThe\tchallenge\tor\treintroduction\tphase\tbegins\tafter\nthe\telimination\tphase\twith\ta\tslow,\tmethodical,\tor\tcontrolled\treintroduction\tof\tone\tFODMAPs\ncategory\tat\ta\ttime\tto\tobserve\tfor\tsymptoms\tand\tidentify\tthe\tmost\tchallenging\tfoods\t(\nVakil,\t2018\n).\nThe\tgoal\tis\tt... | [
0.006387871224433184,
-0.017791422083973885,
0.023132359609007835,
-0.07204724103212357,
-0.12269095331430435,
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0.03359042853116989,
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0.023837612941861153,
0.07213472574949265,
0.11021792143583298,
-0.024890705943107605,
0.06090690195560455,
-0.... |
).\nThe\tgoal\tis\tto\teventually\treduce\tor\teliminate\tGI\tsymptoms\n\tby\tcreating\ta\tdiet\tthat\tincludes\tFODMAPs\nat\tthe\tmost\ttolerable\tintake\tlevel,\tand\twith\tuse\tof\talternative\tfoods.\tIt\tdoes\tnot\tpresent\ta\tcure\tbut\ta\ndietary\tapproach\tto\timprove\tsymptoms\tand\tquality\tof\tlife.\nThe\tke... | [
0.031222863122820854,
-0.06708811968564987,
0.042660702019929886,
-0.03246227651834488,
-0.10546469688415527,
-0.017464235424995422,
0.10698392242193222,
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0.013934032060205936,
0.06882771104574203,
0.1328594982624054,
-0.024122577160596848,
0.0539293996989727,
0.01380... |
knowledgeable\tof\tthe\tdiet\tprinciples.\tThere\tare\tmany\t“lists”\tof\tlow\tFODMAP\tfoods\tavailable,\tand\nthey\tcan\tbe\n\tconfusing\tand\tchallenging\tfor\tthe\tpatient\twho\tis\ttrying\tto\tfollow\tthe\tlow\tFODMAP\tdiet\non\ttheir\town.\tFor\tthis\treason,\tno\tspecific\tlist\tof\tlow\tFODMAP\tfoods\tis\tprovid... | [
-0.01241039764136076,
-0.010057848878204823,
-0.007050635758787394,
-0.020980875939130783,
-0.0479576401412487,
-0.002801631111651659,
0.11069540679454803,
0.0025130894500762224,
-0.032051797956228256,
0.019709527492523193,
0.09559645503759384,
0.014367494732141495,
0.07377296686172485,
0.... |
Monash\tUniversity\tis\ta\treliable\tsource\tfor\tFODMAP\tcontent\tof\tfoods\t(\nGibson,\t2017b\n).\tThe\tMonash\nFODMAPs\tapp,\tavailable\ton\tboth\tiPhone\tand\tAndroid,\tis\tconstantly\tbeing\tupdated\tand\tan\texcellent\nresource\tfor\tclinicians\n\tand\tclients.\tMonash\tUniversity\thas\tother\tresources\ton\tthe\... | [
0.017231673002243042,
-0.10708516091108322,
0.04603032395243645,
-0.04378732666373253,
-0.12758786976337433,
-0.018756259232759476,
0.05250690504908562,
-0.0020171410869807005,
-0.03636248782277107,
0.01685243658721447,
0.1215582937002182,
-0.09595902264118195,
-0.004688727203756571,
0.031... |
as\twell.\nNutritional\tdeficiencies\tthat\tcan\tarise\twith\tthe\tlow\tFODMAPs\tdiet\tinclude\tfolate,\tthiamin,\tvitamin\nB\n6\n,\tand\tfiber\t(from\tlimiting\tcereals\tand\tbreads),\tas\twell\tas\tcalcium\tand\tvitamin\tD\t(if\tavoiding\tall\ndairy\tproducts\tin\taddition\tto\tlactose).\tAn\tRDN\tcan\tprovide\tappro... | [
0.003186824731528759,
-0.026714518666267395,
0.057295698672533035,
-0.029666051268577576,
-0.05921052023768425,
0.018426353111863136,
0.08464062213897705,
0.0191718228161335,
-0.05031845346093178,
0.03793931007385254,
0.11482583731412888,
-0.054736606776714325,
0.043985120952129364,
0.0122... |
an\tadequate\tdiet.\n\tPatients\tmay\twish\tto\tstay\ton\ta\tlow\tFODMAP\tdiet\tto\tmanage\ttheir\tsymptoms;\nhowever,\tit\tis\timportant\tto\tadd\tother\tfoods\tin\tthe\treintroduction\tphase,\tas\tthese\tmay\thave\tfibers\tand\nother\tkey\tnutrients\twhich\twill\tenhance\toverall\thealth.\nSeveral\tqualified\tdietiti... | [
0.0257918369024992,
-0.039341993629932404,
0.04515732824802399,
-0.021583901718258858,
-0.12126324325799942,
0.0075728087686002254,
0.09642013907432556,
-0.0005870210006833076,
0.020264165475964546,
0.04464321956038475,
0.15184088051319122,
-0.019431905820965767,
0.07117781788110733,
-0.00... |
clients\twith\tthe\tlow\tFODMAP\tdiet.\tTwo\tof\tthese\tare\tPatsy\tCatsos,\tMS,\tRDN\n\tand\tKate\tScarlata,\tRDN.\nA\ttraining\tcourse\thas\tbeen\testablished\tat\tthe\tUniversity\tof\tMichigan\tcalled\tFOOD:\tThe\tMain\tCourse\nto\tDigestive\tHealth,\tand\talso\tat\tMonash\tUniversity\t(available\tonline).\nDivertic... | [
0.018385807052254677,
-0.03706762194633484,
0.009516650810837746,
-0.009434046223759651,
-0.1209229975938797,
-0.04649626836180687,
0.09110003709793091,
0.03994656726717949,
0.022742200642824173,
-0.013154242187738419,
0.11760744452476501,
0.0052843946032226086,
0.049704406410455704,
0.023... |
Diverticular\tdisease\nDiverticular\tdisease\tis\tone\tof\tthe\tmost\tcommon\tmedical\tconditions\tamong\tindustrialized\tsocieties.\nDiverticulosis\n\tis\tcharacterized\tby\tthe\tformation\tof\tsac-like\toutpouchings\tor\tpockets\n\t(diverticula)\nwithin\tthe\tcolon\tthat\tform\twhen\tcolonic\tmucosa\tand\tsubmucosa\t... | [
0.02730013243854046,
-0.047549061477184296,
0.08291725069284439,
-0.03287426382303238,
-0.13842475414276123,
0.0012372155906632543,
0.0323457270860672,
0.004835382103919983,
0.03312450274825096,
0.07614906877279282,
0.11130829155445099,
-0.027605175971984863,
0.003689385252073407,
0.037725... |
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