0 stringlengths 12 494 | embeddings listlengths 384 384 |
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Finally,\tthe\tliver\nacts\tas\ta\tfilter\tand\tflood\tchamber\tby\tremoving\tbacteria\tand\tdebris\tfrom\tblood\tthrough\tthe\tphagocytic\taction\tof\nspecialized\tmacrophages\tcalled\t\nKupffer\tcells\n\tlocated\tin\tthe\tsinusoids\tand\tby\tstoring\tblood\tbacked\tup\tfrom\tthe\tvena\ncava\tas\tin\tright\theart\tfai... | [
0.027478866279125214,
-0.05392526462674141,
0.07484360039234161,
-0.06153920292854309,
-0.15070435404777527,
-0.0020217366982251406,
0.08613860607147217,
-0.00596707733348012,
0.010571854189038277,
0.06189208850264549,
0.091208815574646,
-0.051019277423620224,
0.021442953497171402,
0.03656... |
cava\tas\tin\tright\theart\tfailure.\nAssessment\tof\tliver\tfunction\nBiochemical\tmarkers\tare\tused\tto\tevaluate\tand\tmonitor\tpatients\thaving\tor\tsuspected\tof\thaving\n\tliver\tdisease.\tEnzyme\nassays\tmeasure\tthe\trelease\tof\tliver\tenzymes,\tand\tother\ttests\tmeasure\tliver\tfunction.\tScreening\ttests\t... | [
0.006506574805825949,
-0.05394066125154495,
0.05554060637950897,
-0.03973996639251709,
-0.09885832667350769,
0.01729428954422474,
0.08818752318620682,
0.03189079836010933,
0.01022562850266695,
0.0716588944196701,
0.08049599081277847,
-0.06683730334043503,
0.04077724367380142,
0.08559557795... |
hepatobiliary\tdisease\tinclude\tserum\tlevels\tof\tbilirubin,\talkaline\tphosphatase\t(Alk\tPhos),\taspartate\tamino\ttransferase\n(AST),\tand\talanine\taminotransferase\t(ALT).\t\nTable\t28.1\n\telaborates\tcommon\tlaboratory\ttests\tfor\tliver\tdisorders\t(see\nalso\t\nAppendix\t12\n).\nTABLE\t28.1\nCommon\n\tLabora... | [
-0.0197441503405571,
-0.0671900287270546,
-0.006793277803808451,
-0.049269288778305054,
-0.101584792137146,
-0.010477178730070591,
0.05318666622042656,
0.04806864634156227,
-0.000778847374022007,
0.05029667913913727,
0.13269707560539246,
-0.018624871969223022,
0.005959994159638882,
0.04610... |
Laboratory\tTests\tUsed\tto\tTest\tLiver\tFunction\nLaboratory\tTest\nComment\nHepatic\tExcretion\nTotal\tserum\tbilirubin\nWhen\tincreased,\tmay\tindicate\tbilirubin\toverproduction\tor\timpaired\thepatic\tuptake,\tconjugation,\tor\nexcretion\nIndirect\tserum\nbilirubin\nUnconjugated\tbilirubin;\tincreased\twith\texce... | [
-0.028141483664512634,
-0.0727781131863594,
-0.00074104341911152,
-0.039654385298490524,
-0.07856301963329315,
0.007546636741608381,
0.04516733065247536,
0.07176562398672104,
-0.00044653419172391295,
0.07593811303377151,
0.08890901505947113,
-0.03573853150010109,
0.026659836992621422,
0.06... |
enzyme\tsystems,\tinherited\tdefects,\tdrug\teffects\nDirect\tserum\tbilirubin\nConjugated\tbilirubin;\n\tincreased\twith\tdepressed\tbilirubin\texcretion,\thepatobiliary\tdisease,\nintrahepatic\tor\tbenign\tpostoperative\tjaundice\tand\tsepsis,\tand\tcongenital\tconjugated | [
-0.031208787113428116,
-0.09567420184612274,
-0.009751979261636734,
-0.03859592229127884,
-0.07089626044034958,
0.013527904637157917,
0.03894544765353203,
0.05700251832604408,
-0.03195641189813614,
0.05755002051591873,
0.10429025441408157,
0.020193809643387794,
-0.0070660170167684555,
0.09... |
hyperbilirubinemia\nCholestasis\nSerum\talkaline\nphosphatase\nEnzyme\twidely\tdistributed\tin\tliver,\tbone,\tplacenta,\tintestine,\tkidney,\tleukocytes;\tmainly\tbound\tto\ncanalicular\tmembranes\tin\tliver;\tincreased\tlevels\tsuggest\tcholestasis\tbut\tcan\tbe\tincreased\n\twith\nbone\tdisorders,\tpregnancy,\tnorma... | [
-0.036960188299417496,
-0.09474492073059082,
-0.02299155481159687,
-0.033325083553791046,
-0.08958299458026886,
-0.004105383064597845,
0.05750216171145439,
0.06678306311368942,
-0.04185192286968231,
0.05444721505045891,
0.07527941465377808,
-0.0012522374745458364,
-0.018276924267411232,
0.... |
γ-Glutamyl\ntranspeptidase\n(GGT)\nEnzyme\tfound\tin\thigh\tconcentrations\tin\tepithelial\tcells\tlining\tbile\tductules\tin\tthe\tliver;\talso\tpresent\nin\tkidney,\tpancreas,\theart,\tbrain;\tincreased\twith\tliver\tdisease,\tbut\talso\tafter\tmyocardial\ninfarction,\tin\tneuromuscular\tdisease,\tpancreatic\tdisease... | [
-0.03501645103096962,
-0.07142487913370132,
0.014609803445637226,
0.006030977237969637,
-0.09903115779161453,
-0.025426477193832397,
0.058999933302402496,
0.08843961358070374,
-0.04841412976384163,
0.030499987304210663,
0.07058847695589066,
0.017258435487747192,
0.029376955702900887,
0.032... |
and\n\tduring\talcohol\tingestion\nHepatic\tSerum\tEnzymes\nAlanine\naminotransferase\n(ALT,\tformerly\tSGPT,\nserum\tglutamic\npyruvic\ntransaminase)\nLocated\tin\tcytosol\tof\thepatocyte;\tfound\tin\tseveral\tother\tbody\ttissues\tbut\thighest\tin\tliver;\tincreased\nwith\tliver\tcell\tdamage\nAspartate\naminotransfe... | [
0.01566789299249649,
-0.12423840165138245,
0.030086426064372063,
-0.017752060666680336,
-0.1262158304452896,
-0.0051343305967748165,
0.04431349039077759,
-0.019331330433487892,
-0.031008005142211914,
0.04749320447444916,
0.1066882312297821,
-0.03623484447598457,
0.008254102431237698,
-0.00... |
(AST,\tformerly\nSGOT,\tserum\nglutamic\toxaloacetic\ntransaminase)\nLocated\tin\tcytosol\tand\tmitochondria\tof\thepatocyte;\n\talso\tin\tcardiac\tand\tskeletal\tmuscle,\theart,\nbrain,\tpancreas,\tkidney;\tincreased\twith\tliver\tcell\tdamage\nSerum\tlactic\ndehydrogenase\nLocated\tin\tliver,\tred\tblood\tcells,\tcar... | [
0.011141978204250336,
-0.08699356764554977,
0.03321535885334015,
-0.0012192442081868649,
-0.11382155120372772,
-0.001056290464475751,
0.07904035598039627,
-0.018709156662225723,
-0.001602521282620728,
0.061966992914676666,
0.10882902145385742,
-0.022409901022911072,
0.05591411516070366,
0.... |
sensitivity\tand\tspecificity\tbecause\tit\tis\tfound\tin\tmost\tother\tbody\ttissues\nSerum\tProteins\nProthrombin\ttime\t(PT)\nMost\tblood\tcoagulation\tfactors\tare\tsynthesized\tin\tthe\n\tliver;\tvitamin\tK\tdeficiency\tand\tdecreased\nsynthesis\tof\tclotting\tfactors\tincrease\tprothrombin\ttime\tand\trisk\tof\tb... | [
-0.007509348914027214,
-0.08733253926038742,
0.012321313843131065,
-0.03519152104854584,
-0.09147075563669205,
0.01939934305846691,
0.09324721246957779,
0.09754155576229095,
-0.021757090464234352,
0.06660338491201401,
0.09487905353307724,
-0.03265402466058731,
0.022369395941495895,
0.07724... |
International\nNormalized\tRatio\n(INR)\nA\tstandardized\tway\tto\treport\tPT\tlevels\tso\tthat\tlevels\tfrom\tdifferent\tlaboratories\tcan\tbe\tcompared\nSerum\talbumin\nMain\texport\tprotein\tsynthesized\tin\tthe\tliver\tand\tmost\timportant\tfactor\tin\tmaintaining\tplasma\noncotic\tpressure;\thypoalbuminemia\n\tcan... | [
0.01443491131067276,
-0.03923723101615906,
0.04172296077013016,
-0.041858550161123276,
-0.04457889497280121,
0.00903391558676958,
0.06463620066642761,
0.031445495784282684,
0.0047765993513166904,
0.07053205370903015,
0.11197327822446823,
-0.030591009184718132,
0.05759100988507271,
0.036753... |
can\tresult\tfrom\texpanded\tplasma\tvolume\tor\treduced\nsynthesis\tas\twell\tas\tincreased\tlosses\tas\toccurs\twith\tprotein-losing\tenteropathy,\tnephrotic\nsyndrome,\tburns,\tgastrointestinal\tbleeding,\texfoliative\tdermatitis\nSerum\tglobulin\nAlpha\n1\n\tand\talpha\n2\n-globulins\tare\tsynthesized\tin\tthe\tliv... | [
-0.0064621660858392715,
-0.08226335048675537,
0.03360375389456749,
-0.0057951402850449085,
-0.06163286790251732,
0.04495086520910263,
0.04356975108385086,
0.03321731835603714,
-0.059561606496572495,
0.08828660845756531,
0.10429695248603821,
-0.027615489438176155,
0.03422422334551811,
0.058... |
limited\tdiagnostic\tuse\tin\thepatobiliary\tdisease,\talthough\tthe\tpattern\n\tmay\tsuggest\tunderlying\ncause\tof\tliver\tdisease\t(e.g.,\televated\timmunoglobulin\t[Ig]G\tsuggests\tautoimmune\thepatitis,\nelevated\tIgM\tsuggests\tprimary\tbiliary\tcirrhosis,\televated\tIgA\tsuggests\talcoholic\tliver\tdisease)\nMar... | [
0.027008961886167526,
-0.10118617862462997,
0.047989532351493835,
-0.005302491132169962,
-0.10273386538028717,
0.0012106739450246096,
0.05663427338004112,
0.0516410730779171,
-0.026617642492055893,
0.06330104917287827,
0.11694134026765823,
-0.004931435454636812,
0.0397719107568264,
0.06834... |
Markers\tof\tSpecific\tLiver\tDiseases\nSerum\tferritin\nMajor\tiron\tstorage\tprotein;\tincreased\tlevel\tsensitive\tindicator\tof\tgenetic\themochromatosis\nCeruloplasmin\nMajor\tcopper-binding\tprotein\n\tsynthesized\tby\tliver;\tdecreased\tin\tWilson’s\tdisease\nAlpha-fetoprotein\nMajor\tcirculating\tplasma\tprotei... | [
-0.024202970787882805,
-0.03828547149896622,
-0.034911684691905975,
-0.04940410330891609,
-0.04304904490709305,
0.03819296509027481,
0.03621279448270798,
0.10624422878026962,
-0.02553935907781124,
0.07520308345556259,
0.08884017914533615,
-0.02284669131040573,
0.031217724084854126,
0.08757... |
Alpha\n1\n-antitrypsin\nMain\tfunction\tis\tto\tinhibit\tserum\ttrypsin\tactivity;\tdecreased\tlevels\tindicate\talpha\n1\n-antitrypsin\ndeficiency,\twhich\tcan\tcause\tliver\tand\tlung\tdamage\nMarkers\tfor\tViral\nHepatitis\nAnti-HAV\tIgM\n(antibody\tto\nhepatitis\tA\tvirus)\nMarker\n\tfor\thepatitis\tA;\tindicates\t... | [
0.026203595101833344,
-0.054800163954496384,
-0.03826487436890602,
-0.03748751059174538,
-0.028193196281790733,
-0.008893131278455257,
0.0591440349817276,
0.07449058443307877,
-0.05827302485704422,
0.08104361593723297,
0.06458263099193573,
0.037607401609420776,
0.02510416880249977,
0.09425... |
HBsAg\t(hepatitis\tB\nsurface\tantigen)\nMarker\tfor\thepatitis\tB;\tpositive\tin\tmost\tcases\tof\tacute\tor\tchronic\tinfection\nAnti-HBc\t(antibody\tto\nhepatitis\tB\tcore\nantigen)\nAntibody\tto\thepatitis\tB\tcore\tantigen;\tmarker\tfor\thepatitis\tB;\tdenotes\trecent\tor\tpast\thepatitis\ninfection\nAnti-HBs\t(an... | [
0.015518352389335632,
-0.041430748999118805,
-0.011062129400670528,
-0.06032011657953262,
-0.025874193757772446,
0.02016928419470787,
0.005331800784915686,
0.07975202798843384,
-0.09244890511035919,
0.07232886552810669,
0.06132521852850914,
-0.018465746194124222,
0.018436606973409653,
0.04... |
infection\nAnti-HBs\t(antibody\tto\nhepatitis\tB\tsurface\nantigen)\nAntibody\tto\tHBsAg;\tmarker\tfor\thepatitis\tB;\tdenotes\tprior\thepatitis\tB\tinfection\tor\thepatitis\tB\nvaccine;\tprotective\nHBeAg\t(hepatitis\tBe\nantigen)\nMarker\tfor\thepatitis\tB;\ttransiently\tpositive\tduring\tactive\tvirus\treplication;\... | [
0.005395416170358658,
-0.045299042016267776,
-0.018596772104501724,
-0.07767864316701889,
-0.015517226420342922,
0.00832511018961668,
0.01337407249957323,
0.07948961108922958,
-0.08136339485645294,
0.07812371850013733,
0.06096750125288963,
0.0024191064294427633,
0.0697098895907402,
0.07108... |
and\tinfectivity\tof\tvirus\nAnti-HBe\t(antibody\tto\nhepatitis\tBe\nantigen)\nMarker\tfor\thepatitis\tB;\tpositive\tin\tall\tacute\tand\tchronic\tcases;\tpositive\tin\tcarriers;\n\tnot\tprotective\nHBV-DNA\t(hepatitis\tB\ndeoxyribonucleic\nacid)\nMeasures\thepatitis\tB\tviral\tload\nAnti-HCV\t(antibody\tto\nhepatitis\... | [
0.007139815948903561,
-0.02633216232061386,
-0.03958847373723984,
-0.07530882209539413,
-0.010183349251747131,
0.026314258575439453,
0.0014146043686196208,
0.08137907832860947,
-0.08269874006509781,
0.08446377515792847,
0.05652938410639763,
0.006217950023710728,
0.04014182463288307,
0.0825... |
Anti-HCV\t(antibody\tto\nhepatitis\tC\tvirus)\nMarker\tfor\thepatitis\tC;\tpositive\t5-6\tweeks\tafter\tonset\tof\thepatitis\tC\tvirus;\tnot\tprotective;\treflects\ninfectious\tstate\tand\tis\tdetectable\tduring\tand\tafter\ttreatment\nHCV-RNA\t(hepatitis\tC\nvirus\tribonucleic\nacid)\nMeasures\thepatitis\tC\tviral\tlo... | [
-0.009176773950457573,
-0.022990383207798004,
-0.01777832582592964,
-0.06693681329488754,
-0.005635194946080446,
0.022409221157431602,
0.0035174901131540537,
0.08364389091730118,
-0.07964137941598892,
0.08418901264667511,
0.02086835354566574,
-0.00019396109564695507,
0.04236219450831413,
0... |
acid)\nMeasures\thepatitis\tC\tviral\tload\nAnti-HDV\nMarker\n\tfor\thepatitis\tD;\tindicates\tinfection;\tnot\tprotective\nMiscellaneous\nAmmonia\nLiver\tconverts\tammonia\tto\turea;\tmay\tincrease\twith\thepatic\tfailure\tand\tportal-systemic\tshunts\nData\tfrom\tWedemeyer\tH,\tPawlotsky\tJM:\tAcute\tviral\thepatitis... | [
0.02546318620443344,
-0.07374083250761032,
0.010628032498061657,
-0.027498658746480942,
-0.022033916786313057,
0.012166982516646385,
0.011606523767113686,
0.10084421187639236,
-0.04191187769174576,
0.04239194095134735,
0.07057839632034302,
0.007595092058181763,
0.07098747789859772,
0.03611... |
Goldman’s\tCecil\tmedicine\n,\ted\t24,\tPhiladelphia,\t2012,\tElsevier\tSaunders.\nPawlotsky\tJM,\tMchuthinson\tJ:\tChronic\tviral\tand\tautoimmune\n\thepatitis.\tIn\tGoldman\tL\tet\tal,\teditors:\t\nGoldman’s\tCecil\tmedicine,\n\ted\t24,\tPhiladelphia,\t2012,\tElsevier\tSaunders.\nWoreta\tTA,\tAlqahtani\tSA:\tEvaluati... | [
-0.06609752774238586,
-0.037746552377939224,
0.0073541016317903996,
-0.004520809277892113,
-0.07910989969968796,
0.0379752516746521,
0.05901789292693138,
0.0235942080616951,
0.030033588409423828,
-0.003074747510254383,
0.03036968782544136,
0.05521830916404724,
-0.018438998609781265,
0.0054... |
Med\tClin\tNorth\tAm\n\t98:1,\t2014.\tMartin\tP,\tFriedman\tLS:\tAssessment\tof\tliver\tfunction\tand\tdiagnostic\tstudies.\tIn\nFriedman\tLS,\tKeeffe\tB,\teditors:\t\nHandbook\tof\tliver\tdisease\n,\ted\t3,\tPhiladelphia,\t2012,\tElsevier\tSaunders;\t2012.\tKhalili\n\tH\tet\tal:\tAssessment\tof\tliver\tfunction\tin\tc... | [
-0.05503162369132042,
-0.05154090374708176,
0.060843389481306076,
-0.06361641734838486,
-0.10516101866960526,
0.006071515381336212,
0.0874713659286499,
0.049231212586164474,
0.013392781838774681,
0.056056663393974304,
0.06019970029592514,
0.009593183174729347,
0.027596501633524895,
0.04082... |
In\tGines\tP\tet\tal,\teditors:\t\nClinical\tgastroenterology:\tchronic\tliver\tfailure\n,\tNew\tYork,\t2011,\tSpringer. | [
0.005992925260215998,
-0.03286746144294739,
0.02785801701247692,
-0.008508031256496906,
-0.1093226969242096,
-0.025076555088162422,
0.08763700723648071,
0.07632192224264145,
0.00697066355496645,
0.04041093587875366,
0.10965550690889359,
-0.029062749817967415,
0.005127611570060253,
0.059942... |
Physical\texamination\tas\twell\tas\tdiagnostic\tprocedures\t(e.g.,\tendoscopy)\tor\tabdominal\timaging\ttests\t(e.g.,\nabdominal\tultrasound,\tmagnetic\tresonance\timaging,\tor\tcomputed\ttomography\tscan)\tcan\tbe\tused\tto\tdiagnose\tor\nevaluate\tpatients\n\tfor\tliver\tdisease.\tA\tliver\tbiopsy\tis\tconsidered\tt... | [
-0.011632674373686314,
-0.04804546758532524,
0.027259711176156998,
-0.023108670487999916,
-0.1234276071190834,
-0.04098393768072128,
0.059697434306144714,
0.05267854034900665,
0.0042371139861643314,
-0.0250974390655756,
0.10020410269498825,
0.005021371878683567,
0.04284941032528877,
0.0509... |
inflammation\tand\tfibrosis\t(scar\ttissue).\nDiseases\tof\tthe\tliver\nDiseases\tof\tthe\tliver\tcan\tbe\tacute\tor\tchronic,\tinherited\tor\tacquired.\tThe\tfollowing\tsection\tprovides\ta\tbrief\toverview\nof\tviral\thepatitis,\tnonalcoholic\tfatty\tliver\tdisease\t(NAFLD),\talcoholic\tliver\tdisease,\tcholestatic\t... | [
0.03273404762148857,
-0.11628998816013336,
0.031632065773010254,
0.028503932058811188,
-0.059778206050395966,
0.030680319294333458,
0.046529363840818405,
0.05973551422357559,
-0.005522164981812239,
0.0597631074488163,
0.06868667900562286,
0.02785901352763176,
0.03469259664416313,
0.0877594... |
inherited\tdisorders,\tand\tother\tliver\tdiseases.\nViral\thepatitis\nViral\t\nhepatitis\n\tis\ta\twidespread\tinflammation\tof\tthe\tliver\tand\tis\tcaused\tby\tvarious\thepatitis\tviruses,\tincluding\tA,\tB,\tC,\nD,\tand\tE\t(\nFig.\t28.1\n\tand\t\nTable\t28.2\n).\tHepatitis\tA\tand\tE\tare\tthe\tinfectious\tforms,\... | [
-0.0137004554271698,
-0.052921026945114136,
0.06456661969423294,
-0.03031451813876629,
-0.12904341518878937,
0.004778695292770863,
0.0640576183795929,
0.048136889934539795,
-0.047430142760276794,
0.05507113039493561,
0.07130195200443268,
-0.025941288098692894,
-0.015935420989990234,
0.0534... |
Hepatitis\tB,\tC,\tand\tD\texist\tin\tthe\tserum\tand\tare\tspread\tby\tblood\tand\tbody\tfluids\t(\nPawlotsky,\t2016\n).\tInfectious\tagents\nsuch\tas\tEpstein-Barr\tvirus,\tcytomegalovirus,\tand\therpes\tsimplex\tvirus\talso\tcan\tcause\tan\tacute\thepatitis.\nFIG.\t28.1\nA,\n\tNormal\tliver.\t\nB,\n\tLiver\twith\tda... | [
-0.0036679874174296856,
-0.022646816447377205,
0.0051621971651911736,
-0.05364977568387985,
0.0016070050187408924,
0.004804334603250027,
0.04642356187105179,
0.07044754922389984,
-0.07578076422214508,
0.060123808681964874,
0.04788987338542938,
0.013487225398421288,
0.03286534175276756,
0.0... |
B,\n\tLiver\twith\tdamage\tfrom\tchronic\tactive\thepatitis.\t\nC,\n\tLiver\twith\tdamage\tfrom\tsclerosing\tcholangitis.\t\nD,\nLiver\twith\tdamage\tfrom\tprimary\tbiliary\tcirrhosis.\t\nE,\n\tLiver\twith\tdamage\tfrom\tpolycystic\tliver\tdisease\t\n(background)\n\tand\tnormal\tliver\n(foreground)\n.\n\t\nSource: | [
-0.0002323713997611776,
-0.05630866810679436,
0.05884777754545212,
-0.0335969477891922,
-0.05148552358150482,
0.02077576145529747,
0.10346262156963348,
0.01833876222372055,
0.02684834972023964,
0.04811813682317734,
0.07674121111631393,
-0.028853151947259903,
0.06636691093444824,
0.07635009... |
(background)\n\tand\tnormal\tliver\n(foreground)\n.\n\t\nSource:\n\t(Courtesy\tBaylor\tSimmons\tTransplant\tInstitute,\tBaylor\tUniversity\tMedical\tCenter,\tDallas,\tTX.) | [
-0.0010129273869097233,
-0.016430364921689034,
0.018478240817785263,
-0.034081652760505676,
-0.001336598303169012,
-0.02611692249774933,
0.13119487464427948,
0.023241247981786728,
0.03425834700465202,
-0.003981404472142458,
0.0878678411245346,
-0.042132552713155746,
-0.02565804123878479,
0... |
TABLE\t28.2\nTypes\tof\tViral\tHepatitis\nVirus\nTransmission\nComments\nHepatitis\tA\nFecal-oral\troute;\tis\tcontracted\tthrough\ncontaminated\tdrinking\twater,\tfood,\nand\tsewage.\nAnorexia\tis\tthe\tmost\tfrequent\tsymptom,\tand\tit\tcan\tbe\tsevere.\tOther\ncommon\tsymptoms\tinclude\tnausea,\tvomiting,\tright\tup... | [
0.03210087865591049,
-0.06306738406419754,
0.012683598324656487,
-0.04179826006293297,
-0.14436779916286469,
-0.026249969378113747,
0.0705491378903389,
0.05963808298110962,
-0.023537548258900642,
0.09011794626712799,
0.07884661108255386,
-0.02629111334681511,
0.03410158306360245,
0.0467297... |
quadrant\tabdominal\tpain,\tdark\turine,\tand\tjaundice\t(icterus).\nRecovery\tis\tusually\tcomplete,\tand\tlong-term\tconsequences\n\tare\nrare.\tSerious\tcomplications\tmay\toccur\tin\thigh-risk\tpatients;\nsubsequently,\tgreat\tattention\tmust\tbe\tgiven\tto\tadequate\nnutritional\tintake.\nHepatitis\tB\nand\tC\nHBV... | [
0.03226536139845848,
-0.017232149839401245,
0.05299867317080498,
-0.03737742081284523,
-0.1437292993068695,
-0.016468772664666176,
0.07450107485055923,
0.0537157766520977,
-0.015119700692594051,
0.055202506482601166,
0.0904102548956871,
-0.010808143764734268,
0.0306931734085083,
0.04390378... |
Hepatitis\tB\nand\tC\nHBV\tand\tHCV\tare\ttransmitted\tvia\tblood,\nblood\tproducts,\tsemen,\tand\tsaliva.\nFor\texample,\tthey\tcan\tbe\tspread\tfrom\ncontaminated\tneedles,\tblood\ntransfusions,\topen\tcuts\tor\twounds,\nsplashes\tof\tblood\tinto\tthe\tmouth\tor\neyes,\tor\tsexual\tcontact.\nHBV\tand\tHCV\tcan\tlead\... | [
-0.0064307451248168945,
-0.028126567602157593,
0.02728263847529888,
-0.08125881850719452,
-0.048510413616895676,
0.034836169332265854,
0.03681662678718567,
-0.0003096117579843849,
-0.08827697485685349,
0.06679803133010864,
0.07065204530954361,
-0.043801646679639816,
0.007547886110842228,
0... |
HBV\tand\tHCV\tcan\tlead\tto\tchronic\tand\tcarrier\tstates.\tChronic\tactive\nhepatitis\talso\tcan\tdevelop,\tleading\tto\tcirrhosis\tand\tliver\tfailure.\nHepatitis\tD\nHDV\tis\trare\tin\tthe\tUnited\tStates\tand\ndepends\ton\tHBV\tfor\tsurvival\tand\npropagation\tin\thumans.\nHDV\tmay\tbe\ta\tcoinfection\t(occurring... | [
-0.0008014414343051612,
0.010945992544293404,
0.044593822211027145,
-0.03522408753633499,
-0.07024277001619339,
0.011121353134512901,
0.0717015340924263,
-0.00042057791142724454,
0.03738740459084511,
0.08721093833446503,
0.09269837290048599,
-0.016005612909793854,
0.028888652101159096,
0.0... |
HDV\tmay\tbe\ta\tcoinfection\t(occurring\tat\tthe\tsame\ttime\tas\tHBV)\tor\ta\nsuperinfection\t(superimposing\titself\ton\tthe\tHBV\tcarrier\tstate).\nThis\tform\tof\thepatitis\tusually\n\tbecomes\tchronic.\nHepatitis\tE\nHEV\tis\ttransmitted\tvia\tthe\toral-fecal\nroute.\nHEV\tis\trare\tin\tthe\tUnited\tStates\t(typi... | [
0.010206658393144608,
-0.06920697540044785,
0.042882367968559265,
-0.03873654454946518,
-0.11211087554693222,
0.03164844959974289,
0.034624628722667694,
0.02985856868326664,
-0.0004867429961450398,
0.09559084475040436,
0.074805349111557,
-0.004316010512411594,
0.04415687918663025,
0.057399... |
route.\nHEV\tis\trare\tin\tthe\tUnited\tStates\t(typically\tonly\toccurs\twhen\nimported),\tbut\tit\tis\treported\tmore\tfrequently\tin\tmany\tcountries\nof\tsouthern,\teastern,\tand\tcentral\tAsia;\tnorthern,\teastern,\tand\nwestern\tAfrica;\tand\tMexico.\tContaminated\twater\tappears\tto\tbe\nthe\tsource\tof\tinfecti... | [
0.057648543268442154,
-0.07319760322570801,
0.07856538146734238,
-0.007472219876945019,
-0.1135813444852829,
0.00588624132797122,
0.09578746557235718,
-0.05469299107789993,
-0.01931622438132763,
0.06235906481742859,
0.09898092597723007,
-0.05172821506857872,
0.032392486929893494,
0.0241081... |
crowded\n\tand\tunsanitary\tconditions.\tHEV\tis\tgenerally\tacute\nrather\tthan\tchronic.\nHepatitis\nG/GB\nHGV\tand\ta\tvirus\tlabeled\tGBV-C\tappear\nto\tbe\tvariants\tof\tthe\tsame\tvirus.\nAlthough\tHGV\tinfection\tis\tpresent\tin\ta\tsignificant\tproportion\tof\nblood\tdonors\tand\tis\ttransmitted\tthrough\tblood... | [
0.03629374876618385,
-0.08919328451156616,
0.0593554750084877,
-0.04746650159358978,
-0.06867831945419312,
0.011076605878770351,
0.11824922263622284,
-0.0075985160656273365,
-0.013686154969036579,
0.07866017520427704,
0.07602256536483765,
-0.0231701098382473,
0.0283912755548954,
0.04504988... |
does\tnot\tappear\tto\tcause\tliver\tdisease.\nHBV\n,\tHepatitis\tB\tvirus;\t\nHCV\n,\thepatitis\tC\tvirus;\t\nHDV\n,\thepatitis\tD\tvirus;\n\t\nHEV\n,\thepatitis\tE\tvirus;\t\nHGV,\n\thepatitis\tG\tvirus.\nThe\tclinical\tmanifestations\tof\tacute\tviral\thepatitis\tare\tdivided\tinto\tfour\tphases.\tThe\tfirst\tphase,... | [
0.011709185317158699,
-0.0842411145567894,
0.026332959532737732,
-0.060008008033037186,
-0.0690867006778717,
0.0020748653914779425,
0.03036518022418022,
0.04250480979681015,
-0.027861572802066803,
0.08047442883253098,
0.07764233648777008,
0.000992881483398378,
0.0584041103720665,
0.0719493... |
phase,\toften\tis\tcharacterized\tby\tnonspecific\tsymptoms\tsuch\tas\tmalaise,\tloss\tof\tappetite,\tnausea,\tand\tright\tupper\nquadrant\tpain\t(\nPawlotsky,\t2016\n).\tThis\tis\tfollowed\tby\tthe\tpreicteric\tphase,\tin\twhich\tthe\tnonspecific\tsymptoms\ncontinue.\n\tIn\taddition,\tabout\t10%\tto\t20%\tof\tpatients... | [
-0.007256573997437954,
-0.07994399964809418,
0.007259206380695105,
-0.017163775861263275,
-0.13849228620529175,
-0.0010994443437084556,
0.04966025426983833,
0.06959941238164902,
0.014493007212877274,
0.03825229033827782,
0.08070776611566544,
-0.0037635217886418104,
0.052591387182474136,
0.... |
arthritis,\trash,\tand\tangioedema\tin\tthe\tpreicteric\tphase.\tThe\tthird\tphase\tis\tthe\t\nicteric\n\tphase,\tin\twhich\t\njaundice\n\t(a\nyellowing\tof\tthe\tskin,\tmucous\tmembranes,\tand\tthe\teyes)\tappears\tand\tthe\tnonspecific\tsymptoms\tworsen\tand\tweight\nloss,\tdysgeusia\t(distortion\tof\ttaste),\tand\tp... | [
0.010810385458171368,
-0.07296927273273468,
0.07364986836910248,
-0.00003621734140324406,
-0.10431917756795883,
0.0021998300217092037,
0.10176432877779007,
0.023492002859711647,
-0.012292472645640373,
0.04159627482295036,
0.06678161770105362,
-0.009250165894627571,
0.05734289065003395,
0.0... |
develop.\tFinally,\tduring\tthe\tconvalescent\tor\nrecovery\tphase,\tjaundice\tand\tother\tsymptoms\tbegin\tto\tsubside.\nComplete\tspontaneous\trecovery\tis\texpected\tin\tall\tof\thepatitis\tA\tcases,\tin\tnearly\t99%\tof\tacute\thepatitis\tB\tcases\nacquired\tas\tan\tadult,\tbut\tin\tonly\t20%\tto\t50%\tof\tacute\th... | [
0.04262041300535202,
-0.08188048005104065,
0.04457041621208191,
0.0019703858997672796,
-0.09993763267993927,
-0.00725996308028698,
0.05250927805900574,
0.05403641238808632,
-0.054265208542346954,
0.08763035386800766,
0.09376625716686249,
-0.0525093600153923,
0.014665789902210236,
0.0841132... |
with\thepatitis\tE\t(\nPawlotsky,\t2016\n).\tVaccines\texist\tonly\tfor\n\thepatitis\tA\tand\tB;\thowever,\trecent\tadvances\thave\tresulted\nin\teffective\tantiviral\tdrugs\tto\ttreat\tchronic\thepatitis\tB\tand\tC.\nNonalcoholic\tfatty\tliver\tdisease\nNonalcoholic\tfatty\tliver\tdisease\t(NAFLD)\n\tis\ta\tspectrum\t... | [
0.04310014843940735,
-0.13060720264911652,
0.02994154393672943,
0.0037781172432005405,
-0.09177453815937042,
0.010948363691568375,
0.021989239379763603,
0.023299185559153557,
-0.019149256870150566,
0.02967901900410652,
0.0474206879734993,
-0.005252385977655649,
0.031516119837760925,
0.0764... |
and\tcirrhosis.\tIt\tinvolves\tthe\taccumulation\tof\tfat\tdroplets\tin\tthe\thepatocytes\tand\tcan\tlead\tto\tinflammation,\tfibrosis,\ncirrhosis,\n\tand\teven\thepatocellular\tcarcinoma.\tCauses\tof\tNAFLD\tcan\tinclude\tdrugs,\tinborn\terrors\tof\tmetabolism,\tand | [
-0.026211721822619438,
-0.06264086067676544,
-0.008499146439135075,
-0.013498186133801937,
-0.12279340624809265,
-0.031250715255737305,
0.058370329439640045,
0.050706107169389725,
0.05154074355959892,
0.07933638989925385,
0.07737774401903152,
-0.014735736884176731,
0.03740615025162697,
0.0... |
acquired\tmetabolic\tdisorders\t(type\t2\tdiabetes\tmellitus,\tlipodystrophy,\tjejunal\tileal\tbypass,\tobesity,\tand\tmalnutrition).\nHowever,\tNAFLD\tis\tassociated\tmost\tcommonly\twith\tobesity,\ttype\t2\tdiabetes\tmellitus,\tdyslipidemia,\tand\tmetabolic\nsyndrome\t(\nChalasani,\t2016\n).\tInsulin\tresistance\twit... | [
-0.005160011816769838,
-0.0016181356040760875,
-0.0012084315530955791,
0.024227622896432877,
-0.06932350993156433,
-0.021044278517365456,
0.03533124178647995,
0.0875692144036293,
-0.0262571070343256,
-0.00606786273419857,
0.10130485892295837,
0.03675968572497368,
0.012928755953907967,
0.02... |
syndrome\t(\nChalasani,\t2016\n).\tInsulin\tresistance\twith\thyperinsulinism\n\tand\televated\tnonesterified\tfatty\tacid\tlevels\tin\nhepatocytes\tcharacterize\tmetabolic\tdefects\tassociated\twith\tNAFLD.\nThe\tinitial\tstage\tof\tNAFLD\tis\tsteatosis,\twhich\tis\tcharacterized\tby\tthe\tsimple\taccumulation\tof\tfa... | [
-0.030542662367224693,
-0.025334514677524567,
0.009199336171150208,
-0.019776875153183937,
-0.11941257864236832,
-0.03333216533064842,
0.06802854686975479,
0.08650875091552734,
-0.02453777939081192,
0.027141649276018143,
0.0800648108124733,
-0.005954338237643242,
0.029603494331240654,
0.05... |
Some\tpatients\twill\tprogress\tto\t\nnonalcoholic\tsteatohepatitis\t(NASH)\n,\twhich\tis\tan\tinflammatory\tcondition\nassociated\twith\thepatocyte\tinjury\twith\tor\twithout\tfibrous\ttissue\n\tin\tthe\tliver.\tNASH\tcan\tdevelop\tinto\tchronic\tliver\ndisease\tand\tNASH\tcirrhosis\tup\tto\t20%\tof\tthe\ttime.\tThe\t... | [
0.010852848179638386,
-0.04643736779689789,
0.040144432336091995,
0.025522561743855476,
-0.1296875923871994,
-0.002709498628973961,
0.11639487743377686,
0.06448997557163239,
0.0519593209028244,
0.013959684409201145,
0.08493132889270782,
0.011451123282313347,
0.040992628782987595,
0.0684344... |
variable\tdepending\ton\tage\tand\tthe\tpresence\tof\tobesity\tand\ttype\t2\tdiabetes\tmellitus,\twhich\tcontribute\tto\ta\tworsening\nprognosis\t(\nChalasani,\t2016\n).\nThe\ttreatment\tsuggestions\tfor\tNAFLD\tfrom\tthe\tAmerican\tAssociation\tfor\tthe\tStudy\tof\tLiver\n\tDiseases\t(AASLD) | [
0.03781929612159729,
-0.01728055812418461,
0.02261253632605076,
-0.01222277618944645,
-0.1050429567694664,
0.007080430630594492,
0.08894496411085129,
-0.029677018523216248,
0.0066028074361383915,
0.07077567279338837,
0.13121570646762848,
-0.04639535769820213,
0.032274842262268066,
0.042873... |
Diseases\t(AASLD)\ninclude\tlifestyle\tchange\t(diet\tand\texercise),\tweight\tloss,\tinsulin-sensitizing\tdrugs\tsuch\tas\tthiazolidinediones,\tand\nvitamin\tE\t(\nChalasani,\t2016\n).\tBased\ton\tthe\tAASLD\tpanel,\ta\t3%\tto\t5%\tweight\tloss\tcan\timprove\tsteatosis,\tbut\tup\tto\t10% | [
-0.048726871609687805,
-0.0517403706908226,
0.016885578632354736,
0.04138604551553726,
-0.06748249381780624,
-0.021908799186348915,
0.07675562053918839,
0.07635057717561722,
-0.053098998963832855,
0.013843466527760029,
0.0913475975394249,
-0.02138318121433258,
0.002757507609203458,
-0.0122... |
weight\tloss\tmay\tbe\tneeded\tto\timprove\tNASH\tand\tfibrosis.\tThe\tAASLD\trecommendations\tstate\tthat\tpioglitazone\t(an\noral\tantihyperglycemia\tmedication\tused\n\tto\ttreat\tdiabetes\tmellitus)\tmay\tbe\tconsidered\tfor\tNASH\ttreatment,\tbut\tnot\nNAFLD.\tVitamin\tE\t(800\tIU/day\tof\talpha-tocopherol)\tis\tc... | [
-0.03837088122963905,
-0.033657703548669815,
0.03373559191823006,
0.03737499564886093,
-0.10710566490888596,
-0.018144438043236732,
0.10504455119371414,
0.08567332476377487,
-0.03518490865826607,
-0.005489293020218611,
0.04204754903912544,
-0.0324409082531929,
0.018086200580000877,
0.00192... |
patients\twithout\tdiabetes\tmellitus\t(\nChalasani,\t2016\n).\tBecause\tdisease\tprogression\tand\thepatocellular\tinjury\tappears\nto\tbe\tlinked\tto\toxidative\tstress,\tVitamin\tE,\tas\tan\tantioxidant,\tis\tthought\tto\tbe\tbeneficial\t(\nChalasani\tet\tal,\t2018\n).\nOmega-3\tfatty\tacids\tcould\tbe\tconsidered\t... | [
-0.03333815932273865,
-0.02627451717853546,
0.018763259053230286,
-0.006514757871627808,
-0.08746544271707535,
-0.023622997105121613,
0.10715700685977936,
0.09003574401140213,
-0.005356372334063053,
0.010533305816352367,
0.08482050895690918,
0.008961259387433529,
0.024763312190771103,
0.05... |
Chalasani\tet\tal,\n2018\n).\tEmerging\tdata\tsuggest\tdrinking\tmoderate\tamounts\tof\tunsweetened\tcoffee\tis\tprotective\tagainst\tchronic\tliver\ndisease,\tNAFLD,\tand\thepatocellular\tcarcinoma\t(\nMorisco\tet\tal,\t2014\n;\t\nChen\tet\tal,\t2014\n;\t\nSetiawan\tet\tal,\t2015\n).\nAlcoholic\tliver\tdisease\nAlcoho... | [
-0.02764519304037094,
-0.041774217039346695,
0.032634105533361435,
-0.03073001466691494,
-0.08574182540178299,
0.007708714343607426,
0.09432393312454224,
-0.0205957293510437,
0.015290291979908943,
0.09380955994129181,
0.1219550147652626,
-0.042700883001089096,
0.01316380687057972,
0.028719... |
).\nAlcoholic\tliver\tdisease\nAlcoholic\tliver\tdisease\n\tis\tone\n\tof\tthe\tmost\tcommon\tliver\tdiseases\tin\tthe\tUnited\tStates,\twith\t1%\tof\tNorth\tAmericans\nhaving\talcoholic\tliver\tdisease.\tForty\tpercent\tof\tdeaths\tfrom\tcirrhosis\tare\tattributed\tto\talcohol\t(\nChalasani,\t2016\n). | [
0.06236042082309723,
-0.0808272734284401,
0.06085105985403061,
-0.02618296816945076,
-0.09176025539636612,
0.025793014094233513,
0.04836826026439667,
-0.06842848658561707,
-0.007465324364602566,
0.04751887172460556,
0.10840503871440887,
-0.06483938544988632,
0.0009061646996997297,
0.023517... |
Chalasani,\t2016\n).\nAcetaldehyde\tis\ta\ttoxic\tbyproduct\tof\talcohol\tmetabolism\tthat\tcauses\tdamage\tto\tmitochondrial\tmembrane\tstructure\nand\tfunction.\tAcetaldehyde\tis\tproduced\tby\tmultiple\tmetabolic\tpathways,\tone\tof\twhich\tinvolves\n\talcohol\ndehydrogenase\t(see\t\nFocus\tOn:\n\tMetabolic\tConsequ... | [
-0.020173586905002594,
-0.11858949065208435,
0.0024373414926230907,
-0.014017937704920769,
-0.01950901560485363,
0.036508817225694656,
0.061949025839567184,
0.027406401932239532,
-0.022120803594589233,
0.025808047503232956,
0.08807646483182907,
-0.012223745696246624,
-0.035650935024023056,
... |
Metabolic\tConsequences\tof\tAlcohol\tConsumption\n).\n\t\nFocus\tOn\nMetabolic\tConsequences\tof\tAlcohol\tConsumption | [
-0.028987644240260124,
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0.0... |
Ethanol\tis\tmetabolized\tprimarily\tin\tthe\tliver\tby\talcohol\tdehydrogenase.\tThis\tresults\tin\tacetaldehyde\tproduction\nwith\tthe\ttransfer\tof\thydrogen\tto\tnicotinamide\tadenine\tdinucleotide\n\t(NAD),\treducing\tit\tto\tNADH.\tThe\tacetaldehyde\nthen\tloses\thydrogen\tand\tis\tconverted\tto\tacetate,\tmost\t... | [
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... |
Many\tmetabolic\tdisturbances\toccur\tbecause\tof\tthe\texcess\tof\tNADH,\twhich\toverrides\tthe\tability\tof\tthe\tcell\tto\nmaintain\ta\tnormal\tredox\tstate.\tThese\tinclude\thyperlacticacidemia,\tacidosis,\thyperuricemia,\tketonemia,\tand\nhyperlipemia.\tThe\ttricarboxylic\tacid\t(TCA)\tcycle\n\tis\tdepressed\tbeca... | [
0.019530750811100006,
-0.05516660958528519,
0.030765868723392487,
-0.01427324116230011,
-0.08974190801382065,
0.013123917393386364,
0.06870321184396744,
0.013242069631814957,
0.011110593564808369,
0.0687030479311943,
0.09675459563732147,
-0.051943518221378326,
0.0807410329580307,
-0.002154... |
is\tdepressed\tbecause\tit\trequires\tNAD.\tThe\tmitochondria,\tin\tturn,\nuse\thydrogen\tfrom\tethanol\trather\tthan\tfrom\tthe\toxidation\tof\tfatty\tacids\tto\tproduce\tenergy\tvia\tthe\tTCA\tcycle,\nwhich\tleads\tto\ta\tdecreased\tfatty\tacid\toxidation\tand\taccumulation\tof\ttriglycerides.\tIn\taddition,\tNADH\tm... | [
0.038950853049755096,
-0.06637167185544968,
0.042152222245931625,
-0.022638538852334023,
-0.07716861367225647,
0.02639031782746315,
0.0606326162815094,
0.008018295280635357,
-0.025330714881420135,
0.07285292446613312,
0.10667872428894043,
-0.05053550750017166,
0.060907650738954544,
0.03998... |
promote\tfatty\tacid\tsynthesis.\tHypoglycemia\talso\tcan\toccur\tin\tearly\talcoholic\tliver\tdisease\tsecondary\tto\tthe\nsuppression\tof\tthe\tTCA\tcycle,\tcoupled\twith\tdecreased\tgluconeogenesis\tresulting\tfrom\tethanol.\nSeveral\tvariables\tpredispose\tsome\tpeople\tto\talcoholic\tliver\tdisease.\tThese\tinclud... | [
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0.049292173236608505,
-0.008116738870739937,
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0.05084022134542465,
0.052134737372398376,
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0.08180250972509384,
0.13218675553798676,
-0.04284850135445595,
0.0056490167044103146,
0.0... |
intake,\tgenetic\tpolymorphisms\tof\talcohol-metabolizing\tenzymes,\tgender\t(females\tmore\tthan\tmales),\tsimultaneous\nexposure\tto\tother\tdrugs,\tinfections\twith\thepatotropic\tviruses,\timmunologic\n\tfactors,\tobesity,\tand\tpoor\tnutrition\tstatus.\nThe\tpathogenesis\tof\talcoholic\tliver\tdisease\tprogresses\... | [
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0.0025772221852093935,
-0.03268396854400635,
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0.040265824645757675,
0.10514752566814423,
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0.04121772199869156,
0.06698084622621536,
-0.04282029718160629,
0.036646753549575806,
0.0639... |
Fig.\t28.2\n):\thepatic\tsteatosis\t(\nFig.\t28.3\n),\nalcoholic\thepatitis,\tand\tfinally\tcirrhosis.\nFIG.\t28.2\nComplications\tof\texcessive\talcohol\tconsumption\tstem\tlargely\tfrom\texcess\thydrogen\tand\tfrom\tacetaldehyde.\tHydrogen\nproduces\tfatty\tliver\tand\thyperlipemia,\thigh\tblood\tlactic\tacid,\tand\t... | [
0.020868537947535515,
-0.09574717283248901,
0.05335480347275734,
0.014705836772918701,
0.00015438605623785406,
0.03490915521979332,
0.01573987677693367,
0.04758922755718231,
-0.02857474610209465,
0.05215730145573616,
0.07469385862350464,
-0.0034820400178432465,
0.002873325487598777,
0.0003... |
on\tliver\tcells,\tand\tother\tfactors\tas\tyet\tunknown\tlead\tto\talcoholic\thepatitis.\tThe\tnext\tstep\tis\tcirrhosis.\tThe\tconsequent\timpairment\tof\nliver\n\tfunction\tdisturbs\tblood\tchemistry,\tnotably\tcausing\ta\thigh\tammonia\tlevel\tthat\tcan\tlead\tto\tcoma\tand\tdeath.\tCirrhosis\talso\tdistorts | [
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0.07672661542892456,
-0.010268033482134342,
-0.1108991876244545,
-0.024261094629764557,
0.12505117058753967,
0.008029377087950706,
0.02763752080500126,
0.04250721260905266,
0.070065438747406,
-0.025670206174254417,
0.038683004677295685,
0.0519292... |
liver\tstructure,\tinhibiting\tblood\tflow.\tHigh\tpressure\tin\tvessels\tsupplying\tthe\tliver\tmay\tcause\truptured\tvarices\tand\taccumulation\tof\nfluid\tin\tthe\tabdominal\tcavity.\tResponse\tto\talcohol\tdiffers\tamong\tindividuals;\tin\tparticular,\tnot\tall\theavy\tdrinkers\tdevelop\thepatitis\n\tand\ncirrhosis... | [
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0.05995606258511543,
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0.05596066638827324,
0.05710854381322861,
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0.06530279666185379,
0.04040077328681946,
-0.02461371012032032,
0.011007440276443958,
0.044841... |
and\ncirrhosis.\nFIG.\t28.3\nA,\n\tMicroscopic\tappearance\tof\ta\tnormal\tliver.\tA\tnormal\tportal\ttract\tconsists\tof\tthe\tportal\tvein,\thepatic\tarteriole,\tone\tto\ttwo\ninterlobular\tbile\tducts,\tand\toccasional\tperipherally\tlocated\tductules.\t\nB,\n\tAcute\tfatty\tliver.\tThis\tphotomicrograph\ton\tlow\tp... | [
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0.03305518999695778,
-0.016846677288413048,
-0.11392845958471298,
-0.05824519693851471,
0.04326912388205528,
0.03738362342119217,
-0.007003806997090578,
0.04411349073052406,
0.11905781179666519,
-0.010748287662863731,
0.010188470594584942,
0.04192... |
B,\n\tAcute\tfatty\tliver.\tThis\tphotomicrograph\ton\tlow\tpower\texhibits\nfatty\tchange\tinvolving\tvirtually\tall\tthe\thepatocytes,\twith\tslight\tsparing\tof\tthe\tliver\tcells\timmediately\tadjacent\tto\tthe\tportal\n\ttract\n(\ntop\n).\n\t\nSource:\n\t(From\tKanel\tG,\tKorula\tJ,\teditors:\t\nAtlas\tof\tliver\t... | [
-0.020644046366214752,
-0.059766754508018494,
0.06376201659440994,
-0.038657091557979584,
-0.1300627440214157,
-0.009525087662041187,
0.06934892386198044,
0.01915312185883522,
0.0015315843047574162,
0.05442105978727341,
0.14402316510677338,
-0.05313074588775635,
0.037901878356933594,
0.020... |
,\tPhiladelphia,\t1992,\tSaunders.)\nFatty\tinfiltration,\tknown\tas\t\nhepatic\tsteatosis\n\tor\t\nfatty\tliver\n,\tis\tcaused\tby\ta\tculmination\tof\tthese\tmetabolic\ndisturbances:\t(1)\tan\tincrease\tin\tthe\tmobilization\tof\tfatty\tacids\tfrom\tadipose\ttissue;\t(2)\tan\tincrease\tin\thepatic\nsynthesis\tof\tfat... | [
-0.007980041205883026,
-0.0956764668226242,
0.03029553033411503,
-0.004817658104002476,
-0.11700967699289322,
0.01942262426018715,
0.07357054948806763,
0.01998225413262844,
-0.006903795525431633,
0.06385806202888489,
0.14042548835277557,
-0.06352093070745468,
0.009390858933329582,
0.050346... |
synthesis\tof\tfatty\tacids;\t(3)\ta\tdecrease\tin\tfatty\tacid\toxidation;\n\t(4)\tan\tincrease\tin\ttriglyceride\tproduction;\tand\t(5)\ta\ntrapping\tof\ttriglycerides\tin\tthe\tliver.\tHepatic\tsteatosis\tis\treversible\twith\tabstinence\tfrom\talcohol.\tConversely,\tif | [
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0.036613162606954575,
0.031115232035517693,
0.03212720528244972,
0.0019350077491253614,
0.059009090065956116,
0.04910755157470703,
-0.04868581146001816,
-0.04041871428489685,
0.02... |
alcohol\tabuse\tcontinues,\tcirrhosis\tcan\tdevelop.\tPatients\twith\talcoholic\tfatty\tliver\tdisease\tusually\tare\tasymptomatic\nbut\tcan\thave\tsymptoms\tsuch\tas\tfatigue,\tpoor\tappetite,\tright\tupper\tquadrant\tdiscomfort,\tor\thepatomegaly.\nAlcoholic\n\thepatitis\tgenerally\tis\tcharacterized\tby\tan\tenlarge... | [
0.012421755120158195,
-0.07362811267375946,
0.03274363651871681,
0.0012031239457428455,
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-0.0009193368605338037,
0.0650225356221199,
0.02515164017677307,
-0.008824455551803112,
0.0030761943198740482,
0.10522186756134033,
-0.00967694167047739,
-0.0023824498057365417,
0.... |
transaminase\tlevels\t(ALT\tand\tAST),\tincreased\tserum\tbilirubin\tconcentrations,\tnormal\tor\tdepressed\tserum\talbumin\nconcentrations,\tor\tanemia.\tPatients\talso\tmay\thave\tabdominal\tpain,\tanorexia,\tnausea,\tvomiting,\tweakness,\tdiarrhea,\nweight\tloss,\tor\tfever.\tSome\tpatients\tcan\tdevelop\tjaundice,\... | [
0.04964741691946983,
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0.004792477004230022,
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0.03354617953300476,
0.07333017885684967,
-0.07537658512592316,
-0.007913503795862198,
0.040137629956007004,
0.01944858767092228,
0.035176556557416916,
0.02340... |
ascites\n\t(abdominal\tfluid\tretention),\tor\nmental\timpairment\t(\nencephalopathy\n).\tIf\tpatients\tdiscontinue\talcohol\tintake,\thepatitis\tmay\tresolve;\thowever,\tthe\ncondition\toften\tprogresses\tto\tthe\tthird\tstage. | [
0.010344927199184895,
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0.03421325981616974,
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0.07360498607158661,
0.10549017786979675,
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0.06161828711628914,
-0.004668065346777439,
0.0007806547218933702,
0.09... |
Clinical\tfeatures\tof\talcoholic\tcirrhosis,\tthe\tthird\tstage,\tvary.\tSymptoms\tcan\tmimic\tthose\tof\talcoholic\thepatitis;\tor\npatients\tcan\tdevelop\tcomplications\tof\tcirrhosis\tsuch\tas\tgastrointestinal\tbleeding,\n\thepatic\tencephalopathy,\tor\t\nportal\nhypertension\n\t(elevated\tblood\tpressure\tin\tthe... | [
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0.021036691963672638,
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0.0020331067498773336,
0.09105799347162247,
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0.02615024708211422,
0.05843234807252884,
0.0063819498755037785,
0.045690666884183884,
0.0... |
the\tliver).\tPatients\twith\talcoholic\tcirrhosis\toften\tdevelop\tascites,\tthe\taccumulation\tof\tfluid,\tserum\tprotein,\tand\nelectrolytes\twithin\tthe\tperitoneal\tcavity\tcaused\tby\tincreased\tpressure\tfrom\tportal\thypertension\tand\tdecreased\nproduction\tof\talbumin\t(which\n\tmaintains\tserum\tcolloidal\to... | [
0.008430673740804195,
-0.0839071273803711,
0.034823495894670486,
0.008250344544649124,
-0.09026934206485748,
0.0019080834463238716,
0.09570471197366714,
0.03408007696270943,
0.029583824798464775,
0.016821859404444695,
0.09338659048080444,
-0.008495621383190155,
0.05803907662630081,
0.04581... |
micronodular\tcirrhosis,\tbut\tit\tcan\tbe\tmacronodular\tor\tmixed.\tPrognosis\tdepends\ton\tabstinence\tfrom\talcohol\tand\tthe\ndegree\tof\tcomplications\talready\tdeveloped.\tEthanol\tingestion\tcreates\tspecific\tand\tsevere\tnutritional\tabnormalities\n(see\t\nClinical\tInsight:\n\tMalnutrition\tRelated\tto\tAlco... | [
0.009675178676843643,
-0.10831037908792496,
0.05664907768368721,
-0.00037637329660356045,
-0.08077847212553024,
-0.00410305242985487,
0.09251608699560165,
0.059351176023483276,
-0.041502371430397034,
0.07547499239444733,
0.10051333904266357,
-0.0014638141728937626,
0.007132496684789658,
0.... |
Malnutrition\tRelated\tto\tAlcoholic\tLiver\tDisease\n).\nCLINICAL\tINSIGHT\nMalnutrition\tRelated\tto\tAlcoholic\tLiver\tDisease\nSeveral\tfactors\tcontribute\tto\tthe\tmalnutrition\tcommon\tin\tindividuals\twith\tchronic\talcoholic\tliver\tdisease:\n1.\t\nAlcohol\tcan\treplace\tfood\tin\tthe\tdiet\tof\tmoderate\tand\... | [
0.06157364696264267,
-0.0881340503692627,
0.05244789645075798,
0.03022082708775997,
-0.09378557652235031,
0.05532752722501755,
0.08778481185436249,
0.02831491269171238,
-0.05772029981017113,
0.029565652832388878,
0.1167326271533966,
-0.03838406503200531,
0.011926705949008465,
0.02535027265... |
calories\tand\tnutrients.\tIn\tlight\tdrinkers,\tit\tis\tusually\tan\tadditional\tenergy\tsource,\tor\tempty\tcalories.\nAlthough\talcohol\tyields\n\t7.1\tkcal/g,\twhen\tit\tis\tconsumed\tin\tlarge\tamounts\tit\tis\tnot\tused\tefficiently\tas\ta\tfuel\nsource.\tWhen\tindividuals\tconsume\talcohol\ton\ta\tregular\tbasis... | [
-0.006820349488407373,
-0.06400226056575775,
0.04267099127173424,
0.060315974056720734,
-0.08314330875873566,
0.04210638627409935,
0.14089247584342957,
-0.006139625795185566,
-0.035093456506729126,
0.016000522300601006,
0.09789080917835236,
-0.06817546486854553,
-0.02251185104250908,
-0.01... |
they\tare\toften\toverweight\tbecause\tof\tthe\tincreased\tcalories\t(alcohol\taddiction).\tThis\tis\tdifferent\tfrom\tthe\nheavy\tdrinker\twho\treplaces\tenergy-rich\tnutrients\twith\talcohol\t(alcohol\tsubstitution).\n2.\t\nIn\tthe\n\tperson\twith\talcoholism,\timpaired\tdigestion\tand\tabsorption\tare\trelated\tto\t... | [
0.04210813716053963,
-0.09639307111501694,
0.012887917459011078,
0.07045980542898178,
-0.04849523305892944,
0.0414498969912529,
0.10401584208011627,
0.04351801052689552,
-0.03766384720802307,
-0.001690270728431642,
0.10177797824144363,
-0.04340638592839241,
-0.023415228351950645,
0.0245691... |
well\tas\tmorphologic\tand\tfunctional\talterations\tof\tthe\tintestinal\tmucosa.\tAcute\tand\tchronic\talcohol\tintake\nimpairs\thepatic\tamino\tacid\tuptake\tand\tsynthesis\tinto\tproteins,\treduces\tprotein\tsynthesis\tand\tsecretion\nfrom\tthe\tliver,\tand\tincreases\ttissue\tcatabolism\tin\tthe\tgut.\n3.\t\nUse\to... | [
0.027554746717214584,
-0.06009684503078461,
0.05600305274128914,
-0.01897341012954712,
-0.08311545103788376,
0.007069759536534548,
0.07593317329883575,
-0.010299770161509514,
-0.005438370630145073,
0.11023441702127457,
0.09084592014551163,
-0.06957921385765076,
-0.031280502676963806,
0.030... |
3.\t\nUse\tof\tlipids\tand\tcarbohydrates\n\tis\tcompromised.\tAn\texcess\tof\treduction\tequivalents\t(e.g.,\tnicotinamide\nadenine\tdinucleotide\tphosphate\t[NADH])\tand\timpaired\toxidation\tof\ttriglycerides\tresult\tin\tfat\tdeposition\tin\nthe\thepatocytes\tand\tan\tincrease\tin\tcirculating\ttriglycerides.\tInsu... | [
-0.012299529276788235,
-0.08643578737974167,
0.023036843165755272,
-0.040791597217321396,
-0.08761478215456009,
0.034328289330005646,
0.10017994791269302,
0.04628817364573479,
0.0013637804659083486,
0.10455000400543213,
0.07240917533636093,
-0.04155530408024788,
-0.039237551391124725,
0.04... |
4.\t\nVitamin\tand\tmineral\tdeficiencies\toccur\tin\talcoholic\tliver\tdisease\tas\ta\tresult\tof\treduced\tintake\tand\nalterations\tin\tabsorption,\n\tstorage,\tand\tability\tto\tconvert\tthe\tnutrients\tto\ttheir\tactive\tforms.\tSteatorrhea\nresulting\tfrom\tbile\tacid\tdeficiency\tis\talso\tcommon\tin\talcoholic\... | [
0.021907376125454903,
-0.1208106279373169,
0.044845420867204666,
0.001250127679668367,
-0.05140461027622223,
0.03505219519138336,
0.07282696664333344,
0.05310416966676712,
-0.058443110436201096,
0.01559815276414156,
0.08328153938055038,
-0.030276373028755188,
0.005002415273338556,
0.048831... |
absorption.\tVitamin\tA\tdeficiency\tcan\tlead\tto\tnight\tblindness.\tThiamin\tdeficiency\tis\tthe\tmost\tcommon\nvitamin\tdeficiency\tin\tpeople\twith\talcoholism\tand\tis\tresponsible\tfor\tWernicke\tencephalopathy.\tFolate\ndeficiency\tcan\toccur\tas\ta\tresult\tof\tpoor\tintake,\timpaired\tabsorption,\taccelerated... | [
0.03451593220233917,
-0.1235479861497879,
0.06715112924575806,
0.04542289674282074,
-0.05657748505473137,
-0.03993222489953041,
0.13144855201244354,
0.041436612606048584,
-0.05500536784529686,
0.03263130784034729,
0.08842243999242783,
-0.03549312800168991,
0.025014234706759453,
0.027688315... |
storage\tand\tmetabolism.\tInadequate\tdietary\tintake\tand\tinteractions\tbetween\tpyridoxal-5-phosphate\t(active\ncoenzyme\tof\tvitamin\tB\n6\n)\tand\talcohol\treduce\tvitamin\tB\n6\n\tstatus.\tDeficiency\tof\tall\tB\tvitamins\tand\tvitamins\tC,\nD,\tE,\tand\tK\tis\talso\tcommon.\tHypocalcemia,\thypomagnesemia,\tand\... | [
-0.020604761317372322,
-0.09414972364902496,
0.033244501799345016,
-0.011842114850878716,
-0.004337134771049023,
0.05237247049808502,
0.09646943211555481,
0.04756886884570122,
-0.028499018400907516,
0.08064566552639008,
0.08601268380880356,
0.00562297273427248,
0.03734474256634712,
0.03499... |
are\tnot\tuncommon\namong\tpeople\twith\talcoholism;\tfurthermore,\tzinc\tdeficiency\tand\talterations\tin\tother\tmicronutrients\tcan\naccompany\tchronic\talcohol\tintake.\nCholestatic\tliver\tdiseases\nCholestatic\tliver\tdiseases\trefer\tto\tconditions\taffecting\tthe\tbile\tducts.\nPrimary\tbiliary\tcirrhosis\nPrim... | [
0.011586712673306465,
-0.1219257116317749,
0.028518397361040115,
0.011848969385027885,
-0.10186700522899628,
0.028356878086924553,
0.09772184491157532,
0.019795633852481842,
-0.009744757786393166,
0.052908383309841156,
0.09947097301483154,
-0.06314516067504883,
-0.0017659348668530583,
0.05... |
Primary\tbiliary\tcirrhosis\nPrimary\tbiliary\tcirrhosis\t(PBC)\n\tis\ta\tchronic\tcholestatic\tdisease\tcaused\tby\tprogressive\tdestruction\tof\tsmall\n\tand\nintermediate-size\tintrahepatic\tbile\tducts.\tThe\textrahepatic\tbiliary\ttree\tand\tlarger\tintrahepatic\tducts\tare\tnormal. | [
0.0026489591691643,
-0.08785500377416611,
0.009090796113014221,
-0.024630028754472733,
-0.10645843297243118,
-0.010409487411379814,
-0.001837440999224782,
0.09179516136646271,
-0.003552378388121724,
0.08072506636381149,
0.0671643614768982,
-0.030717289075255394,
-0.04552162066102028,
0.056... |
Ninety-five\tpercent\tof\tpatients\twith\tPBC\tare\twomen.\tThe\tdisease\tprogresses\tslowly,\teventually\tresulting\tin\tcirrhosis,\nportal\thypertension,\tthe\tneed\tfor\tliver\ttransplantation,\tor\tdeath\t(\nFogel\tand\tSherman,\t2016\n).\nPBC\tis\tan\tautoimmune\tdisorder\tthat\ttypically\tpresents\twith\tan\telev... | [
0.0075347512029111385,
-0.01231242436915636,
0.04952076077461243,
-0.05271797999739647,
-0.11338651925325394,
0.003921356052160263,
0.07579435408115387,
0.034386903047561646,
0.022122154012322426,
0.03376104682683945,
0.08815206587314606,
0.002464874414727092,
0.040279969573020935,
0.03566... |
of\tserum\tlevels\tof\tAlk\tPhos\tand\tgamma\nglutamyl\ttransferase\t(GGT)\twith\tphysical\tsymptoms\tof\tpruritus\tand\tfatigue.\tSeveral\tnutritional\tcomplications\tfrom\ncholestasis\n\t(a\tblockage\tof\tbile\tflow)\tcan\toccur\twith\tPBC,\tincluding\tosteopenia,\thypercholesterolemia,\tand\tfat-\nsoluble\tvitamin\t... | [
-0.01704331487417221,
-0.05216142535209656,
0.006886604707688093,
-0.013095961883664131,
-0.09239574521780014,
-0.02382126823067665,
0.01782791130244732,
0.09585791826248169,
-0.020360149443149567,
0.012216398492455482,
0.0650109350681305,
0.010698980651795864,
0.028217807412147522,
0.0368... |
soluble\tvitamin\tdeficiencies.\nPrimary\tsclerosing\tcholangitis\nPrimary\tsclerosing\tcholangitis\t(PSC)\n\tis\tcharacterized\tby\tfibrosing\tinflammation\n\tof\tsegments\tof\tintra-\tand\nextrahepatic\tbile\tducts.\tThis\tprogressive\tdisease\tcan\tbe\tcharacterized\tby\tthree\tsyndromes.\tThe\tfirst\tis\tcholestasi... | [
-0.023808926343917847,
-0.09444738179445267,
0.0069576832465827465,
0.01579783856868744,
-0.07137298583984375,
-0.010180863551795483,
0.004202579613775015,
0.10871074348688126,
-0.07401682436466217,
0.03475232422351837,
0.054526567459106445,
0.037260692566633224,
0.03596578910946846,
0.088... |
with\tbiliary\tcirrhosis,\tfollowed\tby\trecurrent\t\ncholangitis\n\t(inflammation\tof\tthe\tbile\tducts)\twith\tlarge\tbile\tduct\nstrictures,\tand\tfinally\tcholangiocarcinoma\t(gall\tbladder\tcancer)\t(\nFogel\tand\tSherman,\t2016\n).\tLike\tPBC,\tPSC\tis\nconsidered\tan\tautoimmune\tdisorder.\n\tIn\tpatients\twith\... | [
0.005437949206680059,
-0.07463435083627701,
0.016342012211680412,
-0.025434628129005432,
-0.1010463759303093,
-0.03851769119501114,
0.05629440397024155,
0.07907716929912567,
0.0007756024715490639,
0.005842375103384256,
0.062039148062467575,
0.03639243170619011,
0.06693083047866821,
0.07627... |
(especially\tulcerative\tcolitis),\tand\tmen\tare\tmore\tlikely\tthan\twomen\t(2:1)\tto\thave\tPSC\t(\nFogel\tand\tSherman,\t2016\n).\nPatients\twith\tPSC\tare\talso\tat\tincreased\trisk\tof\tfat-soluble\tvitamin\tdeficiencies\tresulting\tfrom\tsteatorrhea\tassociated\nwith\tthis\tdisease.\t\nHepatic\tosteodystrophy\n\... | [
-0.010014171712100506,
-0.06410156935453415,
0.05737164616584778,
-0.00796038843691349,
-0.10673597455024719,
-0.00960307102650404,
0.045393314212560654,
0.056004077196121216,
-0.06136547029018402,
0.03637556731700897,
0.08928205817937851,
-0.001513442606665194,
0.010176264680922031,
0.021... |
may\toccur\tfrom\tvitamin\tD\tand\tcalcium\tmalabsorption,\n\tresulting\tin\nsecondary\thyperparathyroidism,\tosteomalacia,\tor\trickets.\tKnown\tfat-soluble\tvitamin\tdeficiencies\tshould\tbe\ttreated,\nand\tcalcium\tsupplementation\tcould\tbe\tconsidered.\tTreatment\tof\tPSC\tis\tmoderately\tsuccessful\twith\tadminis... | [
-0.022923555225133896,
-0.05539395660161972,
0.07152213156223297,
-0.0353829562664032,
-0.05527820810675621,
-0.008663559332489967,
0.0842093750834465,
0.017424724996089935,
-0.031924884766340256,
0.040010739117860794,
0.11052963882684708,
-0.03000618703663349,
0.049283575266599655,
0.0365... |
cholestyramine,\tursodeoxycholic\tacid,\trifampin,\tor\tphenobarbital\t(\nFogel\tand\tSherman,\t2016\n).\nInherited\tdisorders\nInherited\tdisorders\tof\tthe\tliver\tinclude\n\themochromatosis,\tWilson’s\tdisease,\talpha\n1\n-antitrypsin\tdeficiency,\tand\tcystic\nfibrosis.\tPorphyria,\tglycogen\tstorage\tdisease,\tand... | [
-0.004264327231794596,
-0.1008865088224411,
0.0033733060117810965,
-0.03917589783668518,
-0.09507032483816147,
0.005229527596384287,
0.006158243399113417,
0.11318265646696091,
-0.031596243381500244,
0.06453855335712433,
0.07931113988161087,
0.027144471183419228,
0.001887813676148653,
0.041... |
Hemochromatosis\nAlthough\tiron\toverload\tcan\tbe\tassociated\twith\tother\tconditions,\thereditary\t\nhemochromatosis\n\tis\tan\tinherited\ndisease\tof\tiron\toverload\tusually\tassociated\twith\tthe\tgene\tHFE\t(\nMartin,\t2015\n;\t\nBacon,\t2015\n).\tPatients\twith\thereditary | [
-0.026482481509447098,
-0.0008008957956917584,
0.009672531858086586,
-0.022516677156090736,
-0.10592751950025558,
0.017092276364564896,
0.05284184589982033,
0.11554303765296936,
-0.0004942457308061421,
-0.00027923195739276707,
0.06138080731034279,
0.0021115224808454514,
-0.024717193096876144... |
Martin,\t2015\n;\t\nBacon,\t2015\n).\tPatients\twith\thereditary\nhemochromatosis\tabsorb\tand\tstore\texcessive\tiron\tfrom\tthe\tgut\tin\tthe\tliver\theart,\tpancreas,\tjoints,\tand\tendocrine\norgans\t(\nBacon,\t2015\n;\tsee\t\nChapter\t30\n).\tIncreased\ttransferrin\tsaturation\t(at\tleast\t45%)\tand\tferritin\t(mo... | [
-0.03807075321674347,
-0.05160413309931755,
-0.021534744650125504,
-0.021459205076098442,
-0.10007639229297638,
0.003275930415838957,
0.10186226665973663,
0.09719472378492355,
0.021903622895479202,
0.0036957557313144207,
0.09109176695346832,
-0.0024759278167039156,
-0.0023277399595826864,
... |
times\tnormal)\tsuggest\themochromatosis.\tHepatomegaly,\tesophageal\tbleeding,\tascites,\timpaired\thepatic\tsynthetic\nfunction,\tabnormal\tskin\tpigmentation,\n\tglucose\tintolerance,\tcardiac\tinvolvement,\thypogonadism,\tarthropathy,\tand\nhepatocellular\tcarcinoma\tmay\tdevelop.\tEarly\tdiagnosis\tincludes\tclini... | [
-0.009075922891497612,
-0.057905107736587524,
0.05558446794748306,
-0.03831518813967705,
-0.09285401552915573,
-0.003073068568482995,
0.04245268553495407,
0.09318225830793381,
-0.03936151787638664,
0.07323317229747772,
0.06677309423685074,
-0.0506778359413147,
0.028730854392051697,
0.02959... |
elevated\tserum\ttransferrin\tlevels.\tLife\texpectancy\tis\tnormal\tif\tphlebotomy\t(or\tregular\tblood\tdonation)\tis\tinitiated\nbefore\tthe\tdevelopment\tof\tcirrhosis\tor\tdiabetes\tmellitus.\tPatients\twith\themachromotosis\n\tshould\tavoid\tdietary\nsupplements\tthat\tcontain\tiron,\tavoid\tcooking\tin\tcast\tir... | [
-0.010385669767856598,
-0.03297983482480049,
0.06380445510149002,
-0.004949973430484533,
-0.09563755989074707,
-0.019934507086873055,
0.07483983784914017,
0.0850549265742302,
-0.040525179356336594,
0.013657276518642902,
0.09870858490467072,
0.0014991123462095857,
0.06081070750951767,
0.074... |
red\tmeats\t(see\t\nAppendix\t42\n). | [
0.022459877654910088,
-0.0021930132061243057,
-0.03883051127195358,
0.036060888320207596,
-0.014638995751738548,
0.02257164753973484,
0.11976270377635956,
0.03778256103396416,
0.038160763680934906,
-0.00981724914163351,
0.04468175023794174,
-0.024702521041035652,
-0.008999725803732872,
0.0... |
Wilson’s\tdisease\nWilson’s\tdisease\n\tis\tan\tautosomal-recessive\tdisorder\tassociated\twith\timpaired\tbiliary\tcopper\texcretion\t(\nKaler\tand\nSchilsky,\t2015\n).\tCopper\taccumulates\tin\tvarious\ttissues,\tincluding\tthe\tliver,\tbrain,\tcornea,\tand\n\tkidneys.\t\nKayser-\nFleischer\trings | [
0.0006453046225942671,
-0.05851297453045845,
0.07337981462478638,
-0.04438326880335808,
-0.09581799060106277,
0.03294943645596504,
0.07064443081617355,
-0.03974895924329758,
-0.004043207038193941,
0.08060946315526962,
0.08513382822275162,
-0.05053766071796417,
-0.03430453687906265,
0.04019... |
kidneys.\t\nKayser-\nFleischer\trings\n\tare\tgreenish-yellow\tpigmented\trings\tencircling\tthe\tcornea\tjust\twithin\tthe\tcorneoscleral\tmargin,\nformed\tby\tcopper\tdeposits.\tPatients\tcan\tpresent\twith\tacute,\tfulminant\t(occurring\tsuddenly\twith\tgreat\tseverity),\tor | [
-0.03284047171473503,
-0.016750462353229523,
0.09587907046079636,
-0.04099657014012337,
-0.1363179087638855,
-0.05100403353571892,
0.09556574374437332,
0.022881656885147095,
0.028409553691744804,
0.01637556590139866,
0.06301858276128769,
-0.024816662073135376,
0.02563420683145523,
0.030810... |
chronic\tactive\thepatitis\tand\tneuropsychiatric\tsymptoms.\tLow\tserum\tceruloplasmin\tlevels,\televated\tcopper\nconcentration\tin\ta\tliver\tbiopsy,\tand\thigh\turinary\n\tcopper\texcretion\tconfirm\tthe\tdiagnosis.\nCopper-chelating\tagents\t(such\tas\td-penicillamine,\ttrientine,\tor\ttetrathiomolybdate)\t(\nKale... | [
0.000698365387506783,
-0.03667319193482399,
0.02912248857319355,
0.00243394891731441,
-0.06465382128953934,
-0.014657178893685341,
0.09005438536405563,
0.10723288357257843,
-0.013020994141697884,
0.016812248155474663,
0.05977321416139603,
0.0010973786702379584,
0.03356301411986351,
0.04960... |
Kaler\tand\tSchilsky,\t2015\n)\tand\nzinc\tsupplementation\t(150\tmg\telemental\tzinc\tdaily\tgiven\tin\tthree\tdivided\tdoses\tto\tinhibit\tintestinal\tcopper\nabsorption\tand\tbinding\tin\tthe\tliver)\tare\tused\tto\ttreat\tWilson’s\tdisease\tonce\tit\tis\tdiagnosed\t(\nSchilsky,\t2017\n).\tVitamin\nB\n6\n\tsupplemen... | [
-0.03847994655370712,
-0.05515556409955025,
0.060268569737672806,
-0.06255485117435455,
-0.10645667463541031,
0.015102695673704147,
0.1246950551867485,
0.026984870433807373,
0.008769961073994637,
0.07654019445180893,
0.08507148176431656,
-0.026232143864035606,
-0.0108273234218359,
0.030784... |
Schilsky,\t2017\n).\tVitamin\nB\n6\n\tsupplementation\n\tshould\tbe\tconsidered\twhen\tpenicillamine\tis\tgiven\tto\tprevent\tvitamin\tB\n6\n\tdeficiency\t(\nKaler\tand\nSchilsky,\t2015\n).\tOngoing\tintravenous\tcopper\tchelation\tis\trequired\tto\tprevent\trelapses\tand\tliver\tfailure;\tliver | [
-0.004014564678072929,
-0.06907790154218674,
0.03865276649594307,
-0.028324341401457787,
-0.058420293033123016,
0.10407859086990356,
0.09796508401632309,
-0.00019972393056377769,
0.009067216888070107,
0.05982033535838127,
0.06797116994857788,
-0.020454566925764084,
0.01932285726070404,
0.0... |
transplantation\tcorrects\tthe\tmetabolic\tdefect.\tA\tlow-copper\tdiet\tis\tno\tlonger\trequired\tbut\tmay\tbe\thelpful\tin\tthe\ninitial\tphase\tof\ttreatment.\tHigh-copper\tfoods\tinclude\torgan\tmeats,\tshellfish,\tchocolate,\n\tnuts,\tand\tmushrooms.\tFor\ta\ncomprehensive\tlist\tof\tcopper\tcontent\tof\tfood,\tre... | [
-0.06096630170941353,
-0.0644734650850296,
0.04924957826733589,
-0.014925310388207436,
-0.0778796374797821,
-0.029316142201423645,
0.09278177469968796,
0.016326040029525757,
-0.05007457733154297,
0.03310812637209892,
0.1060299202799797,
-0.08268643915653229,
0.03976791724562645,
-0.0166882... |
Database.\tIf\tthis\tdisease\tis\tnot\tdiagnosed\tuntil\tonset\tof\tfulminant\tfailure,\tsurvival\tis\tnot\tpossible\twithout\tliver\ntransplantation.\nAlpha\n1\n-antitrypsin\tdeficiency\nAlpha\n1\n-antitrypsin\tdeficiency\tis\tan\tinherited\tdisorder\tthat\tcan\tcause\tliver\tand\tlung\tdisease.\n\tAlpha\n1\n-antitryp... | [
0.038581281900405884,
-0.04886660724878311,
-0.017387421801686287,
-0.023513777181506157,
-0.10299446433782578,
-0.0019143898971378803,
0.08988033980131149,
0.04441531002521515,
-0.014580829069018364,
0.0793100893497467,
0.11348465830087662,
-0.005953716114163399,
0.05022616311907768,
0.04... |
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