0 stringlengths 12 494 | embeddings listlengths 384 384 |
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DGLA\ttoward\tconversion\tto\tthe\tPGE1\tprostanoids\tinclude\tweight\tmanagement,\timproving\tinsulin\nsensitivity,\tand\tadequate\tnutrient\tstores\tof\tvitamin\n\tD,\tEFA,\tzinc,\tmagnesium,\tB\n6\n,\tand\tothers,\tas\twell\nas\tincreased\tintake\tof\tGLA-rich\toils\t(evening\tprimrose,\tblack\tcurrant,\tborage).\tN... | [
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food\tsources\tstudied\tinclude\tGLA-rich\tplant\toils\tfrom\tevening\tprimrose,\tblack\tcurrant,\tand\tborage\n(\nPickens\tet\tal,\t2015\n).\nThe\tnutritionist\twho\tis\tskilled\tin\tassessing\tan\tindividual’s\tfatty\tacid\tbalance,\tby\tfirst\tperforming\ta\ndietary\tintake\tsurvey\t(see\n\t\nTable\t7.5\n),\tand\tmo... | [
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),\tand\tmore\tspecifically\tby\tobtaining\tan\tRBC\tfatty\tacid\tanalysis,\ncan\tmore\taccurately\ttarget\tinterventions\tto\tsee\timproved\toutcomes\tin\tmanaging\tinflammation.\tWith\nthe\tinformation\tfrom\tan\tRBC\tfatty\tacid\ttest,\tone\tcan\tcalculate\tan\tOmega-3\tIndex,\ta\tprognostic\nindicator\tof\teicosano... | [
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Harris\tet\tal,\t2012\n;\nvon\tSchacky,\t2014\n;\t\nFig.\t7.6\n).\nFIG.\t7.6\nHS-Omega-3\tIndex®\tTarget\tZones.\nThese\tassessment\tparameters\tprovide\ta\troadmap\tthat\tis\table\tto\tguide\tindividualized\tlipid\ninterventions.\tWith\tthis\tinformation,\tthe\tlevels\tof\tlipids\tin\tthe\tbody\tcan\tbe\tmanipulated\t... | [
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healthy\tcomposition,\trestoring\ta\tdegree\tof\toptimum\tinflammation-immune\tresponse\tin\tall\tsystems\tof\nthe\tbody.\tTargeted\tnutrient\ttherapy\tusing\tfood,\tdietary\tsupplements,\n\tand\tfunctional\tfoods\tcan\tbe\nmediators\tof\tthese\tmetabolic\tenzyme\tsystems\tand\thelp\ttake\tadvantage\tof\tthe\tmembrane\... | [
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malleability\taffected\tby\tdietary\tand\tlifestyle\tchanges.\tThese\ttherapies\tusually\trequire\t2\tto\t12\tmonths\nof\tnutrient\ttherapy\tto\tachieve\tsuccessful\toutcomes.\nCytochrome\tP450\tenzymes\nCytochrome\tP450\t(CYP450)\n\tenzymes\tare\tessential\tfor\tthe\tproduction\tof\tcholesterol,\tsteroids,\nprostacycl... | [
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prostacyclins,\tand\tthromboxane\tA\n2.\n\tThey\tare\talso\tinvolved\tin\tthe\tfirst-pass\thydroxylation\tof\nendogenous\tand\texogenous\ttoxic\tmolecules\tin\tthe\tbiotransformation\tand\ttransport\tof\ttoxins\tfor\nelimination\tvia\tthe\tfeces\tand\tbile,\turine,\tand\tsweat.\tIf\tthe\tenzyme\tfunction\tis\tsuppresse... | [
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integrity\tof\tthe\tenzyme\tstructure,\tabnormal\tpH\tmicroenvironment,\thepatic\tinflammation,\taltered\navailability\tof\n\tnutrient\tcofactors,\tor\tCYP450\tgenotypes,\tthen\tthere\tis\ta\tbackup\tof\ttoxins\tand\tan\nincrease\tin\tan\tindividual’s\ttoxic\tload.\tThese\tCYP450\tenzymes\tare\texpressed\tprimarily\tin... | [
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but\tthey\talso\toccur\tin\tthe\tsmall\tintestine,\tkidneys,\tlungs,\tand\tplacenta.\nMore\ttools\tfor\tassessment\tof\tall\tthe\tsystems\tof\tthe\tbody’s\tmetabolism\tare\tbecoming\tavailable.\nTesting\tfor\tthe\tCYP450\tSNP,\tfor\tinstance,\tallows\n\trecognition\tof\ta\tperson’s\tmetabolic\tstrengths\tand\nweaknesse... | [
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Chapter\t6\n).\tAlthough\tthe\tscience\tis\tstill\nevolving\tand\tbeing\tvalidated,\tnutrigenomic\ttesting\tmay\tbe\thelpful\tfor\tproviders\t(including\tdietitians)\nto\tpersonalize\tfood\tand\tnutrition\trecommendations.\nVitamin\tD\nVitamin\tD\t(cholecalciferol)\tactually\tfunctions\tas\ta\tprohormone\twith\tmultipl... | [
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roles,\tincluding\nhormone\tand\timmune\tmodulation,\tantiinflammatory\tand\tantitumor\teffects,\tand\tapoptosis\tsupport\n(Pfotenhauer\tand\tShubrook,\t2017).\tThis\tsuggests\tthat\tvitamin\tD\tis\table\tto\tphysiologically\tcontribute\nto\tthe\tregulation\tof\tall\timmune\tresponses,\tby\tmeans\tof\tthe\tvitamin\tD\t... | [
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the\tnucleus\tof\tthese\tcells.\tEpidemiologic,\tgenetic,\tand\tbasic\tstudies\tindicate\ta\tpotential\n\trole\tof\nvitamin\tD\tin\tthe\tpathogenesis\tof\tcertain\tsystemic\tand\torgan-specific\tautoimmune\tdiseases\t(\nAgmon-\nLevin\tet\tal,\t2013\n).\nVitamin\tD\tis\tactivated\tin\tthe\tskin\tupon\texposure\tto\tUV\t... | [
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used\tin\tnorthern\tand\tsouthern\textreme\tlatitudes),\tas\twell\tas\tobtained\tby\tdietary\tsources\t(fatty\tfish,\nfish\teggs\tor\tcaviar,\torgan\tmeats,\tegg\tyolk,\tand\tmushrooms;\tsee\t\nAppendix\t38\n).\tThe\tpast\tdecade\thas\nspotlighted\tattention\ton\tan\tapparent\tglobal\tepidemic\tof\tlow\tvitamin\tD\tsta... | [
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are\tassociated\twith\tincreased\tprevalence\tof\tlowered\tvitamin\tD\tlevels\tas\tvitamin\tD\t25-OH\tvit\tD\tlevels\nfall\tbelow\t30\tng/mL\t(75\tnmol/L)\t(see\t\nChapter\t5\n).\tRecommendations\tto\ttest\tfor\t25-OH\tvit\tD\tand\nsupplement\tvitamin\tD\tare\tcommon\tto\tincrease\tblood\tlevels\tto\ta\tgoal\tof\tat\tl... | [
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ng/mL\t(75\nnmol/L),\tbut\tsome\trecommend\thigher.\tOptimal\tserum\tlevels\tof\tvitamin\tD\thave\tnot\tbeen\tdefined\t(see\nChapter\t5\n).\tAn\testimate\tis\tthat\tfor\teach\tadditional\t1000\tIU/day\tof\tvitamin\tD\tintake,\tthe\tserum\n25(OH)\tvit\tD\tmay\tincrease\tby\t4\tto\t5\tng/mL\t(10\tto\t20\tnmol/L)\t(\nStip... | [
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).\nVitamin\tD\texhibits\tantiinflammatory\teffects\t(\nKhan,\tM\tet\tal,\t2014\n;\t\nKrishnan\tet\tal,\t2012\n;\t\nKrishnan\tet\nal,\t2013\n).\tAlso,\tas\ta\tnutrient\tpartner,\tvitamin\tA\t(retinol/retinyl\tpalmitate)\thas\ta\trelationship\twith\nvitamin\tD\tin\tthe\tsharing\tof\tthe\tretinoid\tX\treceptor\t(RXR)\twi... | [
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effect\tbetween\tthe\ttwo.\tIn\tnature,\tvitamins\tA\tand\tD\tare\talways\tfound\ttogether\t(e.g.,\tliver,\tegg\tyolk;\nsee\t\nAppendix\t38\n).\tBecause\tof\tthe\tclose\tproximity\tto\tthis\tRXR\tnuclear\treceptor\tin\tall\tcells,\tthere\tis\ta\nsynergistic\trelationship.\tIf\tone\tis\ttoo\thigh\tor\ttoo\tlow,\tit\tcan... | [
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optimal\thealth,\tit\tis\timportant\tto\thave\tadequate\tintake\tof\tvitamin\tA\tand\toptimal\tvitamin\tD\tstatus | [
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(\nSchmutz\tet\tal,\t2016\n).\nMinerals\nMagnesium\nMagnesium\tis\tinvolved\twith\tmore\tthan\t300\tidentified\tenzyme\tsystems\tin\tmetabolism\tand\tblood\nlevels\tare\tinversely\tcorrelated\twith\tC-reactive\tprotein\n\tblood\tvalues\t(\nDibaba\tet\tal,\t2015\n).\tNHANES\ndata\tinvolving\tover\t14,000\tpeople\tbetwee... | [
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low\tserum\tlevels\t(\nZhang\tet\tal,\t2018b\n).\tThe\tpotential\tbeneficial\teffect\tof\tmagnesium\tintake\ton\nchronic\tdisease\tmay\tbe,\tat\tleast\tin\tpart,\texplained\tby\tits\tinhibition\tof\tinflammation\t(\nDibaba\tet\tal,\n2015\n).\nThe\tNHANES\t1999\tto\t2000\tstudy\trevealed\tthat\t60%\tof\tthe\tU.S.\n\tpop... | [
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population\tconsumed\tinadequate\ndietary\tmagnesium\tfrom\tlow\tvegetable\tand\twhole\tgrain\tintake.\tLow\tdietary\tmagnesium\tintake\thas\nbeen\trelated\tto\tseveral\thealth\toutcomes,\tincluding\tthose\trelated\tto\tmetabolic\tand\tinflammatory\nprocesses\tsuch\tas\thypertension,\tmetabolic\tsyndrome\t(\nDiNicolant... | [
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DiNicolantonio\tet\tal,\t2017\n),\ttype\t2\tdiabetes\n(\nHruby\tet\tal,\t2017\n),\tcardiovascular\tdiseases\t(\nLiu\tand\tChacko,\t2013\n;\t\nStevanovic\tet\tal,\t2011\n),\nosteoporosis,\tand\tsome\tcancers\t(e.g.,\tcolon,\tbreast)\t(\nNielsen,\t2010\n).\nMagnesium\trequires\tthe\tmicroenvironment\tof\tother\tessential... | [
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partners,\tcalcium\tand\tzinc.\tDietary\tintake\tof\tchlorophyll-rich\tvegetables,\tnuts,\tand\tseeds\tand\twhole\ngrains\tprovides\tadequate\tmagnesium\tif\tdigestion\tand\tabsorption\tare\tfunctioning\twell\t(see\t\nAppendix\n43\n).\tRecently\tLópez-Alarcón\tand\n\tcolleagues,\tin\ttheir\tstudy\tlinking\tlow-grade\ti... | [
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colleagues,\tin\ttheir\tstudy\tlinking\tlow-grade\tinflammation\twith\nobesity\tin\tchildren,\tlooked\tat\tseveral\tinflammation-related\tbiomarkers\tand\tconcluded\tthat\tthe\tmost\nsignificant\tdeterminants\tof\tinflammation\twere\ta\tmagnesium-deficient\tdiet\tand\tcentral\tobesity\n(\nLópez-Alarcón\tet\tal,\t2014\n... | [
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0.046... |
(\nLópez-Alarcón\tet\tal,\t2014\n).\nZinc\nZinc\tis\ta\tprimary\tcofactor\tfor\tmore\tthan\t300\tenzymes,\tmany\tof\twhich\tare\tinvolved\tin\tinflammatory\nprocesses.\n\tSee\t\nAppendix\t47\n\tfor\tfood\tsources\tof\tzinc.\tIntracellular\tzinc\tis\trequired\tfor\tcell\tsignaling\nwithin\tthe\tintestinal\ttissue\ttrigg... | [
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Ranaldi\tet\tal,\t2013\n).\tZinc\ndeficiency\tleads\tto\tthymic\tatrophy\tand\tdecreased\tfunction.\tThe\tthymus\tgland\tis\tresponsible\tfor\tthe\nproduction\tof\tT-lymphocytes,\ta\tcritical\tpart\tof\timmunity.\nZinc\tis\tthe\tnutrient\tpartner\tto\tcopper,\tso\twhen\n\tassessing\tzinc\tstatus,\tcopper\talso\tshould\... | [
-0.021958002820611,
-0.032097943127155304,
0.05093839019536972,
-0.05559634044766426,
-0.12505722045898438,
0.028775949031114578,
0.10569129139184952,
0.04803032428026199,
-0.049172937870025635,
0.08893726766109467,
0.07811586558818817,
-0.06123727932572365,
0.03205738216638565,
0.04431382... |
assessing\tzinc\tstatus,\tcopper\talso\tshould\tbe\nconsidered.\tGibson\tand\tcolleagues\t(2008)\thave\tdescribed\tloss\tof\ttaste\t(especially\tin\tthe\telderly)\twith\nzinc\tdeficiency,\tand\tthis\tshould\tbe\tnoted\twhen\ttaking\ta\thistory\tfrom\tan\tindividual.\tBecause\talkaline\nphosphatase\t(Alk\tPhos)\tis\ta\t... | [
-0.05449816584587097,
-0.011029454879462719,
0.05787009373307228,
0.0154262725263834,
-0.015833130106329918,
-0.0031589576974511147,
0.07705514132976532,
0.03882597014307976,
-0.019485339522361755,
0.0504821352660656,
0.06278795748949051,
-0.02986389771103859,
0.02828960306942463,
0.059984... |
further\tinvestigation\tis\tneeded\tfor\tzinc\tdeficiency.\n\tSerum\tzinc\tlevels\tonly\tprovide\tinformation\tabout\nfrank\tzinc\tdeficiency\tand\tare\tnot\treliable\tto\tassess\tfor\tmarginal\tstatus.\tCurrently,\tassessing\tfor\ndietary\tintake\tis\tthe\tmost\tefficient\tway\tto\testimate\tzinc\tadequacy.\nMethylati... | [
0.03998316079378128,
-0.0599835030734539,
0.061150841414928436,
-0.05486392602324486,
-0.11057072132825851,
0.0023986627347767353,
0.07061982899904251,
-0.008151102811098099,
-0.005768906325101852,
0.07592806220054626,
0.10584121197462082,
-0.044195227324962616,
0.015012525953352451,
0.057... |
Methylation\nMethylation\tis\tuniversal\tthroughout\tmetabolism,\tand\tmethyl\tdonors\tare\tprimary\tpromoters\tof\nhealthy\tmethylation.\tThe\tB\tcomplex\tvitamins\twork\tsynergistically\tand\tare\n\tcritical\tto\tthe\tmethylation\nprocess.\tFolate,\tB\n6\n,\tB\n2\n,\tand\tB\n12\n\thave\tbeen\tshown\tto\tbe\tthe\tmost... | [
0.02643507905304432,
-0.012781786732375622,
-0.0009526083013042808,
-0.059334646910429,
-0.04373212531208992,
0.025057103484869003,
0.03279845044016838,
0.02511265128850937,
-0.011465920135378838,
0.05136324465274811,
0.11956872791051865,
-0.08059331774711609,
-0.010588676668703556,
0.0166... |
12\n\thave\tbeen\tshown\tto\tbe\tthe\tmost\trate-limiting\twhen\tinsufficient.\nAlthough\tthe\tresults\tare\tpreliminary,\tthere\tmay\tbe\tmetabolic\tadvantages\tto\tsupplementing\twith\nmethylated\tforms\tof\tB\tvitamins.\tThis\tis\ttrue,\tfor\texample,\twith\tthe\tmethylation\tdefect\tSNPs\tMTHFR\n677C\tor\tMTHFR\t12... | [
0.002641411265358329,
-0.02940443530678749,
0.0034964410588145256,
-0.07148891687393188,
-0.05793492868542671,
-0.02264637127518654,
0.03669356927275658,
-0.005581606645137072,
-0.02878265082836151,
0.0631500706076622,
0.09815719723701477,
0.0007671257480978966,
0.06751377135515213,
-0.011... |
acid\tis\tused\n(\nBailey\tet\tal,\t2010\n;\t\nManshadi\tet\tal,\t2014\n;\t\nMiller,\t2010\n;\t\nVollset,\t2013\n)\t(see\t\nClinical\tInsight\n:\tSynthetic\nand\tBioactive\tB-Complex\tVitamins\n).\nCLINICAL\tINSIGHT\nSynthetic\tand\tBioactive\tB-Complex\tVitamins | [
-0.014364738017320633,
-0.05737874656915665,
0.006622781977057457,
0.0028899800963699818,
-0.00552004249766469,
0.059583090245723724,
0.042473286390304565,
0.03343798965215683,
-0.02249850519001484,
0.049965184181928635,
0.14023813605308533,
-0.04230288416147232,
-0.014910000376403332,
0.0... |
B-Complex\tVitamins\nSynthetic\tForm/Common\nName\nBioactive\tNatural\tForm\tin\tFoods\nB1\nThiamin\tmononitrate\nThiamin\thydrochloride\nThiamin\t(benfotiamine)\nB2\nRiboflavin\nRiboflavin-5-phosphate\nB3\nNicotinic\tacid\nNiacin\t(generic\tterm)\nNicotinamide\tadenine\tdinucleotide\t(NAD)\nNAD\tphosphate\t(NADP)\nNia... | [
-0.055398017168045044,
-0.061247918754816055,
-0.03293842077255249,
-0.05982799082994461,
-0.025645786896348,
0.04614802077412605,
0.005996963009238243,
0.11022379249334335,
-0.0009205886162817478,
0.06711239367723465,
0.04947597533464432,
-0.0473346933722496,
0.03236584737896919,
0.055059... |
Niacinamide\nB5\nPantothenic\tacid\nD-pantothenate\nPanthenol\nPantothenate\nB6\nPyridoxine-HCl\nPyridoxine-5-phosphate\t(P5P)\nB12\nCyanocobalamin\nMethylcobalamin\nHydroxycobalamin\nAdenosylcobalamin\nB9\nFolic\tAcid\nFolinic\tAcid\n5-Methyltetrahydrofolate\n5-Formyltetrahydrofolate\nB7\nBiotin\nBiotin\n(Biocytin) | [
-0.06022055819630623,
-0.014987953938543797,
-0.025130875408649445,
-0.037564124912023544,
-0.002821150003001094,
0.040688175708055496,
-0.052652690559625626,
0.05360069125890732,
-0.005926977377384901,
-0.0043363734148442745,
0.014178895391523838,
-0.06602789461612701,
0.06082793325185776,
... |
5-Formyltetrahydrofolate\nB7\nBiotin\nBiotin\n(Biocytin)\nTo\tdate,\tthe\tmethylation\tsystem\tmost\tassociated\twith\tinflammation\tof\tchronic\tdisease\tis\tthe\nmethylation\tof\tDNA,\twhich\tis\tespecially\tsensitive.\tChronic\tdiseases\trelated\tto\tmethylation\tfrom\nepigenetic\tinfluences\tfrom\tthe\tenvironment\... | [
-0.011129029095172882,
-0.07437233626842499,
0.03146012872457504,
-0.053645797073841095,
-0.06516221910715103,
0.04625234007835388,
0.035607773810625076,
0.0490100271999836,
-0.01043661218136549,
0.09024810791015625,
0.11286800354719162,
-0.0951867401599884,
-0.017216304317116737,
0.078424... |
(\nEhrlich,\t2002\n),\tinflammatory\tbowel\tdisease\n\tsuch\tas\tCrohn’s\tdisease\t(\nKaratzas\tet\tal,\t2014\n),\tcognitive\ndysfunction,\tmood\tdisorders\t(\nHing\tet\tal,\t2014\n),\tand\tcardiovascular\tdisease\t(\nDelbridge\tet\tal,\t2015\n).\nThe\tmechanisms\tsupporting\tmethylation\thave\timportant\timplications\... | [
-0.04882221296429634,
-0.02487100660800934,
0.04645086079835892,
-0.004761260002851486,
-0.08454504609107971,
0.0004885201342403889,
0.010869753547012806,
0.06151234358549118,
0.03185921907424927,
0.06786008924245834,
0.08149674534797668,
-0.023978592827916145,
-0.021913882344961166,
0.073... |
response\t(\nKominsky\tet\tal,\t2010\n).\tThese\tmechanisms\trely\ton\tB\tvitamin\tcofactors\tand\tthe\trole\tthey\nplay\tin\thomocysteine\tmetabolism\tas\twell\tas\tthe\teicosanoid\n\tcascade\twhich\tproduces\tthe\tinflammation\nreducing\tprostaglandins\t(\nNazki\tet\tal,\t2014\n).\tThese\tmethyl\tfactors\tare\tinvolv... | [
-0.05658966302871704,
-0.014402136206626892,
0.023554254323244095,
-0.023304959759116173,
-0.06046268343925476,
0.002463460201397538,
0.03175213560461998,
0.038959261029958725,
0.03699305281043053,
0.039772871881723404,
0.06742940098047256,
-0.007009793538600206,
0.023840755224227905,
0.00... |
).\tThese\tmethyl\tfactors\tare\tinvolved\tin\tturning\ton\tgene\nexpression\tassociated\twith\tneurotransmitters,\tnitric\toxide\t(NO),\tand\tmethionine\tmetabolism,\twhich\nare\tprecursors\tto\tantiinflammatory\tcompounds\tthat\tprotect\tagainst\toxidative\tstress.\nThe\tmethylation\tgenes\tare\tcurrently\tthe\tmost\... | [
0.019996797665953636,
-0.01462359819561243,
0.025480011478066444,
-0.023848993703722954,
-0.07821143418550491,
0.016433384269475937,
0.07183389365673065,
0.0008128021145239472,
0.028720205649733543,
0.08101747184991837,
0.11691354215145111,
-0.08009914308786392,
0.029081907123327255,
0.011... |
provide\tdata\tfor\nclinical\tapplication.\tMost\tnational\tlaboratories\tprovide\ttesting\tfor\tthe\tgenes\tMTHFR\tC667T,\tMTHFR\n1298C,\tand\tCOMT.\tOthers\tare\tavailable\tat\tspecialty\tlabs\t(see\t\nChapter\t6\n\tand\t\nFig.\t7.7\n).\nFIG.\t7.7\nMethylation\tMechanism.\nFlavonoids\tand\tantioxidant\tnutrients | [
-0.056841108947992325,
-0.022854428738355637,
-0.007466113194823265,
-0.02321666106581688,
-0.031435925513505936,
0.019823113456368446,
0.0656295195221901,
0.028503699228167534,
-0.02734331786632538,
0.010159362107515335,
0.10889941453933716,
-0.04092125967144966,
-0.008040539920330048,
0.... |
FIG.\t7.7\nMethylation\tMechanism.\nFlavonoids\tand\tantioxidant\tnutrients\nFlavonoids\tor\tbioflavonoids\tare\tphytonutrients\tassociated\twith\tthe\tvaried\tcolors\tfound\tin\tfruits\tand | [
-0.03147689625620842,
-0.03453223779797554,
0.027694866061210632,
0.06307147443294525,
-0.0140455923974514,
0.08300410956144333,
0.08220423758029938,
0.029152529314160347,
-0.011531783267855644,
0.046648841351270676,
0.1030878946185112,
-0.08753632009029388,
-0.020140808075666428,
-0.00777... |
vegetables.\tThese\tphytonutrients\tprovide\tantiinflammatory\tantioxidant\tfunctions\tbeneficially\nmessaging\tthe\timmune\tsystem\t(\nIslam\tet\tal,\t2016\n;\t\nJeena\tet\tal,\t2013\n).\tThey\tprovide\tprotection\tagainst\nfree\tradical\tand\treactive\n\toxygen\tspecies\t(ROS)\tactivity\tthat\tcause\tinflammation,\ta... | [
-0.031801145523786545,
-0.06101156398653984,
0.01599264331161976,
0.03591256961226463,
0.0032282210886478424,
0.07695089280605316,
0.0842738226056099,
0.046011511236429214,
-0.03864547237753868,
0.04612889140844345,
0.14885500073432922,
-0.04282631725072861,
0.011306033469736576,
-0.034103... |
epigenetic\teffects\tby\tinteracting\twith\tthe\tfatty\tacid\tand\tprostaglandin\tstatus\tof\ta\tperson.\nWhen\tthe\tantioxidant\tand\tflavonoid\tstatus\tis\tinadequate\tto\tprotect\tcells\tand\ttissues,\taccelerated\ndamage\toccurs,\tpromoting\tdegeneration,\tand\tdepleting\tthe\thealth\tof\tthe\tindividual.\tThe\tmos... | [
-0.011974642984569073,
-0.05885348096489906,
0.02258601039648056,
-0.038385260850191116,
-0.09911411255598068,
0.05870627984404564,
0.07124695181846619,
-0.010885588824748993,
-0.011703252792358398,
0.09040661156177521,
0.12185951322317123,
-0.06060417741537094,
0.0026370282284915447,
0.00... |
studied\tflavonoid\tcompound\tresearched\tto\n\tdate\tis\t\ncurcumin\n,\ta\tcomponent\tof\tthe\tspice\tturmeric\n(\nAgrawal\tet\tal,\t2015\n;\t\nTuorkey,\t2014\n).\tAnother\texample\tis\t\nquercetin\n,\ta\tcomponent\tof\tcitrus\tpulp,\napples,\tand\tonions,\twhich\tis\ta\tyellow\tflavonoid\twith\tantiinflammatory\tacti... | [
-0.0032390833366662264,
-0.0032841102220118046,
0.0406566746532917,
-0.03222860395908356,
-0.12629209458827972,
0.05724355950951576,
0.06814868003129959,
-0.0013429030077531934,
0.040844716131687164,
0.025126183405518532,
0.06799432635307312,
-0.03621642291545868,
0.014275187626481056,
0.0... |
Quercetin-rich\tfoods\tare\thelpful\tin\tquelling\tallergic\tor\tsensitivity\treactions\t(\nKim\tet\tal,\t2014\n;\t\nLee\tet\nal,\t2013\n).\tBoth\tof\tthese\tflavonoid\tcompounds,\tas\n\twell\tas\tothers,\tare\talso\tavailable\tin\tsupplemental\nform\tfor\ttargeted\tnutritional\ttherapy\twhen\tindicated\t(\nBox\t7.5\n)... | [
-0.01544920727610588,
-0.06631596386432648,
0.010749143548309803,
0.018427034839987755,
-0.0688592717051506,
0.06246654689311981,
0.06310448050498962,
0.0012454383540898561,
-0.006050655618309975,
0.024404188618063927,
0.09366727620363235,
-0.0285637266933918,
0.0066440049558877945,
-0.031... |
BOX\t7.5\nSelected\tFlavonoid\tAntioxidants\nAlpha\tLipoic\tAcid\nAstaxanthin\nCitrus\tBioflavonoids\nCoQ10\nCurcumin\nEpigallocatechin\t3\tGallate\t(EGCG)\nGlutathione\nLutein\nLycopene\nQuercetin\nResveratrol\nZeaxanthin\nSeveral\tantioxidant\tsystems\tare\tinvolved\tin\tprotection\n\tagainst\tthese\tROS—especially\t... | [
-0.02618996985256672,
-0.050091907382011414,
-0.037424325942993164,
0.03825528547167778,
-0.003876602044329047,
0.048535458743572235,
0.09570184350013733,
0.0802387148141861,
0.010748305357992649,
0.0009751924080774188,
0.06320451200008392,
-0.01162533275783062,
-0.017852647230029106,
0.01... |
against\tthese\tROS—especially\twithin\tthe\nelectron\ttransport\tsystem\tin\tthe\tmitochondria.\tAmong\tthe\t80\tor\tmore\tknown\tantioxidants,\tascorbate\n(vitamin\tC)\thas\tbeen\tshown\tto\treact\twith\tother\tbiologic\tantioxidants\treferred\tto\tas\tthe\t“antioxidant\nnetwork.”\tAscorbate\tacts\tas\ta\tcentral\tre... | [
0.006077725440263748,
-0.014559591189026833,
0.03386933356523514,
-0.002867461647838354,
-0.02707529626786709,
0.030899174511432648,
0.08824224025011063,
0.027009770274162292,
-0.01660274527966976,
0.04722025245428085,
0.09878996759653091,
-0.024134917184710503,
0.039343804121017456,
-0.00... |
(\nStipanuk\tand\tCaudill,\t2013\n).\tAscorbate\tinteracts\twith\tthe\tvitamin\n\tE\tcomplex\tto\tprovide\tprotection\nto\twater-\tand\tlipid-soluble\tsurfaces\tin\tmembranes.\tOther\tkey\tmembers\tof\tthe\tantioxidant\tnetwork\nare\t\nglutathione\n,\tanother\twater-soluble\tantioxidant\tthat\tis\tsynthesized\tin\tall\... | [
-0.046564795076847076,
-0.0598943866789341,
0.03215218707919121,
-0.019683290272951126,
0.012149620801210403,
0.03688447177410126,
0.11381205171346664,
0.024653179571032524,
-0.021227285265922546,
0.00217061722651124,
0.07523799687623978,
-0.04727031663060188,
0.026310548186302185,
0.02341... |
supports\tthe\tcentral\trole\tof\tascorbate\tand\tvitamin\tE;\t\nlipoic\tacid\n\twith\tits\twater\tand\tlipid\tmolecular\ncomponents\tand\tsometimes\tconsidered\tthe\t“universal\tantioxidant”;\tand\t\ncoenzyme\tQ\n10\n\tthat\nfunctions\tin\tprotecting\tlipid\tstructures,\tespecially\tin\tcardiac\tmuscle\tand\tmitochond... | [
-0.05336134880781174,
-0.07122905552387238,
0.01345418393611908,
-0.04022872447967529,
-0.022910114377737045,
0.01165965385735035,
0.09215255081653595,
0.05607936158776283,
-0.02614731155335903,
0.009218045510351658,
0.07387334108352661,
-0.03820208087563515,
-0.04778365045785904,
0.082735... |
Antioxidants\twork\tsynergistically\tto\tquell\tROS\tactivity.\tThese\tnutrients\tare\tnatural\tmetabolites\tin\nhealthy\tindividuals\tand\tcan\tbe\tused\tas\tsupplements\tfor\thealth-compromised\tindividuals\tif\tindicated.\nGut\tecology\tand\tthe\tmicrobiome\nThe\tgastrointestinal\ttract\thas\tmany\tfunctions\tin\tth... | [
0.012770751491189003,
-0.035629045218229294,
0.01954413391649723,
0.022141695022583008,
-0.033302098512649536,
0.04032029211521149,
0.09614457190036774,
0.017549758777022362,
-0.03841237351298332,
0.07153115421533585,
0.12648051977157593,
-0.0609462596476078,
0.010560005903244019,
-0.00944... |
of\tan\tindividual,\tand\tone\tof\tthem\tis\tin\nimmune\tintegrity.\tThis\tis\tbecause\tthe\tlargest\timmune\torgan\tis\tlocated\twithin\tthe\tgastrointestinal\ntract\tas\tgut-associated\tlymphoid\ttissue\t(GALT)\tand\tmucosa-associated\tlymphoid\ttissue\t(MALT),\ncontaining\tinnate\tand\tacquired\timmune\tsystems\tas\... | [
0.03826526552438736,
-0.06013927236199379,
0.03153262287378311,
-0.008126922883093357,
-0.08065417408943176,
0.0048490725457668304,
0.08746645599603653,
0.02690175361931324,
0.013871029950678349,
0.06865312904119492,
0.1045122742652893,
-0.04334148392081261,
-0.002688238862901926,
0.045142... |
organisms.\tThe\tcondition\tof\tthe\tgut\tlymphoid\ttissue\tand\tthe\tmicrobial\n\tecology\thas\ta\tlarge\tinfluence\non\tthe\tbody’s\tinflammatory\tstate\t(\nLewis,\t2014\n).\tThe\tinverse\trelationship\tof\tgut\tbarrier\tintegrity\tand\necology\twith\torgan\tspecific\tor\tsystemic\tinflammation\tis\twell\tdocumented\... | [
0.02267286740243435,
-0.05523522570729256,
0.044778551906347275,
-0.05620934069156647,
-0.11347512155771255,
0.0028028436936438084,
0.023580310866236687,
-0.022669697180390358,
0.02521904930472374,
0.11367861181497574,
0.10688068717718124,
-0.10773145407438278,
0.001960506197065115,
0.0656... |
Goldman\tand\tSchafer,\n2012\n;\t\nHold\tet\tal,\t2014\n;\t\nKinnebrew\tand\tPamer,\t2012\n;\t\nPastorelli\tet\tal,\t2013\n;\t\nRuth\tand\tField,\t2013\n).\nMedical\tnutrition\ttherapy\trecommendations\tto\tsupport\tthe\tmicrobial\tecology\n\tinclude\tincreasing\nintake\tof\tfermented\tfoods\tand\tfiber,\tdecreasing\th... | [
-0.03910868242383003,
-0.07194246351718903,
0.006186032667756081,
0.027641108259558678,
-0.03021465428173542,
0.005796070676296949,
0.0955556184053421,
0.010169579647481441,
-0.015187468379735947,
-0.031867366284132004,
0.0718623474240303,
0.008950332179665565,
-0.033903978765010834,
0.007... |
antigens,\tespecially\tthose\tthat\taffect\tthe\tgastrointestinal\ttract\t(such\tas\tfood\tallergens).\tTherapeutic\nuse\tof\tfunctional\tfoods\t(\nAbuajah,\t2015\n),\tpre-\tand\tprobiotics\t(\nIsolauri\tand\tSalminen,\t2015\n),\tand\tfiber\nsupplements\tcan\tsometimes\tbe\tused\tto\trestore\toptimum\tgut\tfunction\tan... | [
0.0052141910418868065,
-0.08302929997444153,
0.024277476593852043,
-0.08232506364583969,
-0.050116781145334244,
0.03398405760526657,
0.06830081343650818,
0.05453018844127655,
-0.03516469895839691,
0.045883022248744965,
0.12134412676095963,
-0.05238834396004677,
0.013749634847044945,
0.0714... |
inflammation\n(\nLuoto\tet\tal,\t2013\n;\tsee\t\nChapters\t25\n\tand\t\n27\n).\nLifestyle\nLifestyle\tfactors\tsuch\tas\tpoor\tsleep,\tphysical\tinactivity,\tand\tsmoking\tcontribute\tto\tinflammation\tand\nchronic\tdisease.\tToxic\tenvironmental\texposures,\tstress,\tsocial\tisolation\tand\tpoor\tinterpersonal\nrelati... | [
0.0006742983823642135,
-0.08969654142856598,
0.065891794860363,
0.01867169886827469,
-0.038410406559705734,
0.029403572902083397,
0.09821539372205734,
0.056568119674921036,
-0.014989078044891357,
0.048362813889980316,
0.054909951984882355,
-0.029741711914539337,
0.029757047072052956,
0.073... |
relationships\thave\talso\tbeen\tidentified\tas\tinfluencing\tfactors\t(\nTay\tet\tal,\t2013\n;\t\nUmberson\tand\tMontez,\n2010\n).\nSleep:\tCircadian\n\trhythm\nThe\tCDC\ttargets\tsleep\tinsufficiency\tas\tan\timportant\tpublic\thealth\tchallenge\twith\t50\tto\t70\tmillion\nU.S.\tadults\tdiagnosed\twith\tsleep\tdisord... | [
-0.04523598030209541,
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-0.11625568568706512,
0.020952928811311722,
0.025781260803341866,
-0.030725963413715363,
0.05980628356337547,
-0.003296460257843137,
0.10811600089073181,
-0.050919659435749054,
0.06605029851198196,
0... |
CDC,\t2018\n;\t\nCDC\t2014a\n).\tSleep\tquality\tand\tduration,\n“feeling\trefreshed”\tupon\tawaking,\tand\thaving\tgood\tenergy\tthroughout\tthe\tday\tuntil\tbedtime\tare\tthe\nsigns\tof\tadequate\tsleep.\tGood-quality\tsleep\thelps\treduce\tblood\tmarkers\tof\tinflammation\tincluding | [
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0.06425568461418152,
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0.029421072453260422,
0.09205727279186249,
0.027669163420796394,
0.03221423178911209,
0.04081939533352852,
0.059572283178567886,
-0.06438855826854706,
0.031647056341171265,
0.0288... |
CRP-hs\n\t(\nIrwin\tet\tal,\t2016\n).\tCommon\thabits\tthat\tdisrupt\tsleep\tinclude\twatching\tTV\tor\tlooking\tat\ncomputers\tand\tcell\tphones.\tElectronic\tdevices\tproduce\tpenetrating\tlight\tthat\treduces\tthe\tbody’s\nproduction\tof\tmelatonin\t(the\tnatural\tsleep\thormone\tresponding\tto\tdarkness).\tSleep\ta... | [
-0.015684176236391068,
-0.07965131103992462,
0.07398782670497894,
-0.06314024329185486,
-0.05164780467748642,
0.027732377871870995,
0.10369211435317993,
0.005150944925844669,
-0.009642301127314568,
0.05713498964905739,
0.10316577553749084,
-0.04494764655828476,
0.035486768931150436,
0.0239... |
and\tfor\tsome,\tconsumption\tof\tcaffeinated\tfood\tand\tdrinks\talso\tcontribute\tto\tpoor\tsleep\tquality.\tThe\ncumulative\teffects\n\tof\tpoor\tsleep\taffect\tmetabolic\tactivities\tthat\tmay\tlead\tto\tweight\tgain,\tmood\ndisorders,\tand\tfeelings\tof\tstress\t(\nHeaney,\t2012\n).\tSleep\tproblems\tcan\tcontribu... | [
0.010425211861729622,
-0.08952388912439346,
0.03586961701512337,
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0.13303811848163605,
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0.01928410492837429,
0.039380740374326706,
0.07604723423719406,
-0.03874702379107475,
0.06971341371536255,
0.03239... |
Heaney,\t2012\n).\tSleep\tproblems\tcan\tcontribute\tto\tdiseases\tsuch\tas\nhypertension,\theart\tdisease,\tdepression,\tand\tdiabetes.\nClinical\tinsight\nThe\trole\tof\tthe\tvagus\tnerve\tin\tinflammation\nThe\tstatus\tof\ta\tperson’s\tvagus\tnerve\tis\toften\tnot\tconsidered\tin\tassessing\tchronic\tinflammation.\n... | [
0.028275711461901665,
-0.0796579048037529,
0.042024388909339905,
-0.04544737935066223,
-0.0887765884399414,
0.04349146783351898,
0.11073922365903854,
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0.069842629134655,
0.05218382924795151,
-0.04703159257769585,
0.03370828181505203,
0.0121277756... |
The\nvagus\tnerve\tthe\tlongest\tcranial\tnerve\tconnecting\tthe\tbrain\tto\tthe\tbody,\tand\tregulating\tmany\nsystems,\tespecially\tgastrointestinal\tfunction\tand\tinflammation.\tPoor\tvagal\ttone\tinhibits\tthe\tability\tto\nachieve\tparasympathetic\tfunction\tinfluencing\toptimum\tdigestion\t(\nYuen\tet\tal,\t2017... | [
0.025127001106739044,
-0.06705265492200851,
0.053447969257831573,
0.017843127250671387,
-0.13258448243141174,
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0.0511137917637825,
0.041614830493927,
0.021509433165192604,
0.022607609629631042,
0.08440975099802017,
-0.028798123821616173,
0.035882726311683655,
0.0336... |
Yuen\tet\tal,\t2017\n;\t\nGerritsen\tet\tal,\n2018\n).\tDuring\ta\tphysical\texamination\ta\tsimple\tscreening\tfor\tvagal\ttone\tis\thaving\ta\tpatient\tperform\n\ta\ngag\treflex\tstatus\tby\tusing\ta\ttongue\tdepressor\tpushing\tdown\ton\tthe\ttongue\tstarting\tat\tthe\ttip\tand\nincrementally\tproceeding\ttoward\tth... | [
-0.003516663797199726,
-0.05216153711080551,
0.06507786363363266,
-0.03300965577363968,
-0.14656305313110352,
0.0364028662443161,
0.06527474522590637,
0.01725861057639122,
0.01537358108907938,
-0.02547757513821125,
0.10427790135145187,
-0.057960499078035355,
0.021764593198895454,
0.0112353... |
healthy\tvagal\ttone\tshould\tproduce\ta\tgag\tresponse\twithin\t1\tto\t2\tcm\tof\tdepressing\tthe\ttip\tof\tthe\ntongue.\tAn\timportant\trole\tof\tthe\t\nvagal\tnerve\n\tis\tcontrolling\tthe\tpromotion\tof\tSPM\tand\tresolution\tof\ninflammation.\n\tThis\twould\tbe\timportant\tif\ta\tpatient\thistory\tincludes\ta\tvag... | [
0.0038154367357492447,
-0.031863801181316376,
0.050470177084207535,
-0.006200911942869425,
-0.10251494497060776,
0.0336073562502861,
0.10593897849321365,
0.01180566381663084,
-0.022430190816521645,
0.011397586204111576,
0.0987996757030487,
0.0005398340290412307,
0.04471677169203758,
0.0238... |
Mirakaj\tet\tal,\t2014\n).\nLifestyle\tinterventions\tcan\tbe\trecommended\tthat\thave\tstrong\tevidence\tto\timproving\tvagal\ttone\tand\nfunction,\teffecting\tcontrol\tof\tinflammation\t(e.g.,\tmeditation,\tyoga,\tlaughing,\tgargling)\t(\nGerritsen\tet\nal,\t2018\n;\t\nLoizzo,\t2016\n).\nPhysical\tactivity\nIn\tthe\t... | [
0.02842051349580288,
-0.07922579348087311,
0.09092304855585098,
-0.0032132561318576336,
-0.11046545207500458,
0.03648935258388519,
0.09403263032436371,
0.012751209549605846,
0.0009191518765874207,
0.06331200152635574,
0.08880532532930374,
-0.06739398092031479,
0.001984555274248123,
0.05012... |
In\tthe\tmedical\tliterature,\tphysical\tactivity\tis\toften\tassociated\n\twith\tan\timprovement\tin\tinflammatory\nmarkers.\tParticipants\tin\tthe\tMulti\tEthnic\tStudy\tof\tAtherosclerosis\t(mean\tage\t64)\twho\texercised\tfrom\na\tmoderate\tto\tvigorous\tlevel\thad\treduced\tblood\tlevels\tof\tmultiple\tinflammator... | [
0.03135775402188301,
-0.08466089516878128,
0.05848821625113487,
0.00683311652392149,
-0.12286101281642914,
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0.06321903318166733,
0.05551307648420334,
0.018062718212604523,
0.05041094124317169,
0.07068140059709549,
-0.06992029398679733,
0.028950894251465797,
0.086753107... |
IL-6,\tleptin,\tand\tresistin\t(an\tadipocyte\tspecific\thormone\tassociated\twith\tinsulin\tresistance).\tThese\nresults\twere\tfound\tin\tall\tethnicities\tand\twere\tnot\tdiminished\n\tby\tthe\tpresence\tof\tobesity\tor\tother\ncardiometabolic\trisk\tfactors\t(\nVella\tet\tal,\t2016\n).\tMultiple\tstudies\thave\tsho... | [
-0.03936588019132614,
-0.01814793236553669,
0.06713943183422089,
-0.04721993952989578,
-0.09518620371818542,
0.0332416407763958,
0.054777227342128754,
0.00592813128605485,
0.013439277186989784,
0.06512673944234848,
0.09616024047136307,
-0.031195009127259254,
-0.004698184784501791,
0.017431... |
).\tMultiple\tstudies\thave\tshown\tan\tinverse\trelationship\nbetween\tphysical\tactivity\tand\tinflammatory\tmarkers\tsuch\tas\tCRP-hs\tand\tTNF-α\t(\nWoods\tet\tal,\t2012\n).\nIn\tyoung\tsedentary\tadults,\t12\tweeks\tof\taerobic\ttraining\timproved\taerobic\tcapacity\tbut\tdid\tnot\nreduce\tinflammatory\tmarkers.\t... | [
-0.016065161675214767,
-0.07698217779397964,
0.061692629009485245,
-0.006168641149997711,
-0.06251006573438644,
0.005743693094700575,
0.13049067556858063,
0.027315247803926468,
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0.03982431814074516,
0.08590617775917053,
-0.050956279039382935,
0.04047133028507233,
0.044... |
increased\tleading\tthe\nauthors\tto\tconclude\tthat\tthe\tantiinflammatory\tpotential\tof\tphysical\tactivity\tmay\tbe\tpopulation\tand\nsituationally\tspecific\t(\nSloan\tet\tal,\t2018\n).\tAlthough\tstudies\ton\tthe\teffect\ton\tinflammation\tare\tmixed,\nthe\toverall\thealth\tbenefit\tof\tphysical\tactivity\tin\tmo... | [
0.005592915695160627,
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0.06324189901351929,
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0.09064269065856934,
0.0359741635620594,
0.017857514321804047,
0.07327979058027267,
0.09966277331113815,
-0.056507792323827744,
0.03379431366920471,
0.03659... |
Stress\tof\tlife\nSome\thealth\tprofessionals\tand\tresearchers\thave\ttheorized\tthat\tprolonged\n\tunresolved\tstress\ton\tthe\nbody\tis\tone\tof\tthe\tprimary\tpromoters\tof\tearly\taging\tand\tchronic\tdisease.\tThe\tunresolved\tstate\tof\nstress,\twhether\temotional,\tphysical,\tor\tperceived,\tor\tfrom\tinfection... | [
0.0012377422535791993,
-0.027511371299624443,
0.04504008963704109,
0.03330721706151962,
-0.07128599286079407,
0.040687188506126404,
0.09933394938707352,
-0.008723591454327106,
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0.06135585904121399,
0.08793888241052628,
-0.05732230842113495,
0.0293933916836977,
0.00985... |
system\tto\trespond\twith\tmore\tinflammatory\tcytokines.\tThe\tanalogy\tused\tto\tdescribe\tunrelenting\nstress\tis\tgetting\tready\tfor\tthe\t“fight\tor\tflight”\tresponse,\twith\tnowhere\tto\trun.\tUnder\n\tthe\tinfluence\tof\na\tshort-term\tstressor,\tthe\tbody\tis\table\tto\tclear\tthe\tinflammatory\tand\tstress\t... | [
-0.01377404760569334,
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0.012625409290194511,
0.11279857158660889,
0.011344565078616142,
0.03686222806572914,
0.08950714766979218,
0.08723770081996918,
-0.019910726696252823,
0.10286517441272736,
-0.0057... |
happen\twith\tunrelenting\tchronic\tstress\t(\nLiu\tet\tal,\t2017\n)\nToxin\tload\nToxins\tare\tendogenous\tand\texogenous\t\nxenobiotics\n,\ttoxic\tsubstances\twithin\ta\tbiologic\torganism,\nthat\tdamage\tthe\tmetabolism.\nIn\tthe\tmodern\tworld,\tsince\tWorld\tWar\tII,\tthere\thave\tbeen\t80,000\tor\tmore\tsynthetic... | [
-0.031957585364580154,
-0.025715157389640808,
0.05849158763885498,
-0.02130676619708538,
-0.05205356702208519,
0.01526194903999567,
0.045517366379499435,
-0.0015067767817527056,
0.06880837678909302,
0.06469903141260147,
0.14140331745147705,
-0.06768786907196045,
0.026000728830695152,
0.055... |
and\nmany\ttoxic\tmetals\treleased\tinto\tthe\tenvironment,\tincreasing\tthe\texposure\tof\tplant\tand\tanimal\tlife\tto\nan\tunprecedented\tlevel\t(\nNRDC,\t2019\n).\tAlthough\tmany\thistorical\tcompounds\tsuch\tas\tsmoking\tare\ntoxic\t(\nAdams\tet\tal,\t2015\n),\tmany\ttoxic\tcompounds\tare\t“new-to-nature”\tmolecul... | [
-0.022518817335367203,
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0.07362096011638641,
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0.02439754083752632,
0.04007110744714737,
-0.038616713136434555,
0.005961010232567787,
0.08343006670475006,
0.10109487920999527,
-0.07363820821046829,
0.027580944821238518,
0.037... |
in\tthe\tenvironment\t(\nAris\tand\tLeblanc,\t2011\n;\t\nBland,\t2007\n).\tAn\texample\tis\ttrans\tfatty\tacids\t(\nGanguly\nand\tPierce,\t2015\n).\nThe\tmetabolisms\tof\tplants\tand\tanimals\tusually\thave\tdifficulty\tproviding\tthe\tsystems\tto\tprocess\tand\neliminate\tthese\ttoxins\twhen\tincorporated\tinto\tthe\t... | [
0.013563757762312889,
-0.0018209019908681512,
0.05505518615245819,
-0.033538833260536194,
-0.060648396611213684,
0.0031033020932227373,
0.09533713012933731,
-0.030035873875021935,
0.011606110259890556,
0.05524892359972,
0.11173693835735321,
-0.07570970058441162,
0.04161025211215019,
0.0295... |
have\tchallenged\tattempts\tat\tgovernmental\tregulation\tof\tthese\ttoxic\tcompounds.\tThe\tresult\thas\tbeen\nincreasing\ttissue\tlevels\tof\tsome\tof\tthese\ttoxins\twhen\ttissue\ttesting\tis\tperformed.\tExamples\tof\tthese\nincreased\tlevels\tare\tshown\tin\tstudies\tof\tnewborn\tcord\tblood,\twhich\thave\tfound\t... | [
0.037529025226831436,
-0.03385004773736,
0.062321946024894714,
-0.040232881903648376,
-0.07549583911895752,
0.026197833940386772,
0.031147371977567673,
-0.094725102186203,
-0.01632370986044407,
0.07892634719610214,
0.02192915789783001,
-0.04197423532605171,
0.09969937801361084,
-0.02396117... |
environmental\tchemicals\tin\ta\tpopulation\tof\turban\tU.S.\tnewborns\t(\nMorello-Frosch\tet\tal,\t2016\n).\nAnother\texample\tis\tstudies\tof\ttoxic\tcadmium\tand\tlead\tmetals\tin\tKorean\tpopulations\tresiding\tnear\nabandoned\tmetal\tmines.\tA\tstudy\tof\tmore\tthan\t5000\tKoreans\tfound\tnotably\thigher\ttoxic\tm... | [
0.006714478135108948,
-0.009148543700575829,
0.042132895439863205,
-0.028798220679163933,
-0.06456971168518066,
-0.031697120517492294,
0.060676299035549164,
-0.013118451461195946,
-0.010226654820144176,
0.0906110629439354,
0.13482312858104706,
-0.06277402490377426,
0.04008708521723747,
-0.... |
in\tthose\tresiding\twithin\n\ta\t2-km\tradius\tof\tthe\tmines\tthan\tin\tthe\tgeneral\tpopulation\tin\tKorea\tand\tother\ncountries\t(\nPark\tet\tal,\t2014\n).\tCadmium\tand\tlead\tare\tknown\tcarcinogens\tand\tare\trelated\tto\tcentral\nnervous\tsystem\t(CNS)\tdisturbances\tand\tcardiovascular\tand\trenal\tdiseases\t... | [
0.003402132773771882,
-0.012669275514781475,
0.06492137908935547,
-0.022912586107850075,
-0.060309600085020065,
-0.01534960325807333,
0.08716319501399994,
0.04894731566309929,
0.009001370519399643,
0.06152575463056564,
0.10459335148334503,
-0.047322530299425125,
0.017575012519955635,
0.044... |
prolonged\tinflammation.\nA\tstudy\ton\thermetic\t(low-level)\texposure\tto\tcadmium\tand\tarsenic\trelated\tto\tclinical\tsymptoms\nfound\tthat\tlow\n\tdietary\tprotein\tintake\taffected\tenzyme\tactivity\tsuch\tthat\tdepressed\tbiologic\tsystems\nand\tlong-term\tadaptations\twere\tinadequate\t(\nDudka\tet\tal,\t2014\... | [
0.02453196607530117,
-0.054194070398807526,
0.07732602953910828,
0.0011679197195917368,
-0.09023083746433258,
0.0076683275401592255,
0.06358248740434647,
0.07628859579563141,
-0.028581850230693817,
0.05160089582204819,
0.09328629076480865,
-0.04965592920780182,
0.034569159150123596,
0.0334... |
Dudka\tet\tal,\t2014\n).\tLack\tof\tdietary\tvegetable\nmicronutrient\tand\tphytonutrient\tintake\thas\trepeatedly\tbeen\tshown\tto\tincrease\tthe\tinflammatory\neffects\tof\ttoxins\tsuch\tas\ttoxic\tmetals,\tchemicals,\tand\tpesticides\t(\nBakırcı\tet\tal,\t2014\n,\t\nJeena\tet\tal, | [
-0.0324554406106472,
-0.04564104229211807,
-0.01639244146645069,
0.010455073788762093,
-0.08576377481222153,
0.05710712447762489,
0.08952073007822037,
0.03391610458493233,
0.05071287602186203,
-0.0022004004567861557,
0.09478608518838882,
-0.04193622246384621,
0.0006585009396076202,
0.03136... |
2013\n).\tAdequate\tintake\tof\tmacro-\n\tand\tmicronutrients\tmay\tprovide\tprotection\tfrom\ttoxin\texposures\nsuch\tas\tfrom\thigh\tintake\tof\tvegetables\tand\tadequate\tprotein.\nAssessment\tand\treducing\tprolonged\tinflammation\tin\tchronic\tdiseases\nThe\tpatient’s\tstory\nNutrition\tassessment\tincludes\tgathe... | [
0.009613902308046818,
-0.018030699342489243,
0.07412984222173691,
-0.015696877613663673,
-0.11316917836666107,
0.04124317690730095,
0.0929822102189064,
0.01984214223921299,
-0.005239139776676893,
0.02813110128045082,
0.10015571862459183,
-0.01749775931239128,
0.02506917156279087,
0.0270615... |
the\tpatient’s\tstory\tand\tforming\tthe\ttherapeutic\trelationship\tthat\tis\tfoundational\n\tfor\tthe\tmost\neffective\toutcomes.\tIt\tis\ta\ttype\tof\tdetective\twork\tpartnering\twith\tthe\tclient\tto\tuncover\troot\tcauses\tof\nunderlying\tphysiologic\timbalances,\tincluding\tinflammation\tthat\tframe\tthe\tinterv... | [
0.030740870162844658,
-0.04191296175122261,
0.0619896836578846,
-0.020127233117818832,
-0.13468730449676514,
0.014796318486332893,
0.07772589474916458,
0.022029072046279907,
0.06004364788532257,
0.023110706359148026,
0.08271803706884384,
-0.021223966032266617,
0.04344044625759125,
0.021902... |
The\t\npatient’s\tstory\n\tis\ta\tterm\tinclusive\tof\tthe\twhole\tof\tthe\tpatient’s\thistory\tand\tcurrent\tstate\tof\nhealth;\tit\tis\ta\tcollection\tof\tall\tdata\tthat\tpotentially\tcan\tcontribute\tto\tthe\tindividual’s\thealth.\n\tIn\tthe\ntherapeutic\tencounter\tthe\tdata\tis\tcollected\tfrom\tthe\tpersonal\tin... | [
0.02320210076868534,
-0.012308090925216675,
0.03137977048754692,
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0.048289693892002106,
0.04347753897309303,
0.09400960057973862,
-0.008924001827836037,
0.03764215111732483,
0.022461... |
family\thistory\tfrom\tmultiple\tgenerations\tif\tpossible,\tclinical\tobservation,\tand\tcurrent\tlaboratory\nrecords.\tMost\toften\ta\tpattern\tsuggesting\tmetabolic\tgenotypes\tcan\tbe\trecognized.\tExamples\tlike\ncardiovascular,\tautoimmune,\tor\tneurologic\tevents\trepeated\tin\tfamily\tmembers,\tespecially\tat\t... | [
0.01331371907144785,
-0.03316590562462807,
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0.05872894451022148,
0.11590966582298279,
-0.05607279762625694,
0.0017580658895894885,
-0.... |
ages\tor\tin\tmultiple\trelatives,\tshould\tprompt\tthe\tnutritionist\tto\tinvestigate\tpossible\tmetabolic\nmechanisms\tand\tSNPs.\tQuantitative\tlaboratory\tor\tclinical\tconfirmation\tof\tan\taltered\tmetabolism\nmay\tbe\tappropriate\tbefore\tplanning\tan\tintervention.\nPersonal\thealth\thistory,\tfrom\tgestation\t... | [
0.030042970553040504,
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0.08002844452857971,
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0.06528475880622864,
0.10173935443162918,
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0.03765911981463432,
0.022869... |
timeline\tof\tmajor\tlife\tevents\tand\thealth\tchallenges.\tThis\n\tcan\tgive\tinsight\tinto\tpatterns\tthat\thave\ncontributed\tto\ta\tperson’s\tcurrent\tstate\tof\thealth\tor\tdisease.\tFor\texample,\tinfants\tnot\tbreastfed\tare\nfound\tto\thave\tmore\tdifficulty\tin\tmaintaining\thealthy\tgut\tmicrobiota,\tand\tin... | [
-0.013241524808108807,
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0.02847908064723015,
0.09503486007452011,
-0.061743106693029404,
0.019902680069208145,
-0.0... |
allergies\tand\tasthma.\tThese\tinfants\tmay\tbenefit\tfrom\tprobiotic\tsupplementation\t(\nPrescott\tand\nNowak-Wegrzyn,\t2011\n).\nMedical\thistory\tand\tdata\nInflammation\tis\n\ta\tcommon\tdenominator\tin\tnearly\tevery\tchronic\tdisease.\tMost\tevidence\tof\tthis\nphenotype\tamong\thumans,\tcenters\taround\tvariou... | [
0.02418069913983345,
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0.09135410934686661,
0.12044557183980942,
-0.07292591780424118,
0.0015817106468603015,
0.0394... |
metabolic\tsyndrome\n\tdescribed\tas\npresenting\twith\ta\tcluster\tof\trisk\tfactors\tincluding\tinsulin\tresistance\t(IR)/\nhyperinsulinemia\n,\nincreased\tVAT\t(increased\tbody\tfat\tpercentage\tand\twaist\tcircumference),\televated\tblood\ttriglycerides\n(TG)/lowered\thigh-density\tcholesterol\n\t(HDL-chol),\thyper... | [
-0.03763594105839729,
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0.03163798898458481,
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0.02901727519929409,
0.10664303600788116,
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0.019230561330914497,
0.02216276153922081,
0.023067403584718704,
-0.066... |
(dysglycemia)\t(\nWatson,\t2014\n).\tAn\tadditional\tbiomarker\tis\tseen\tcommonly\tas\televated\tCRP-hs\tblood\nvalues\tgreater\tthan\t1.0.\tIncreased\tunderstanding\tof\tdysregulation\tof\tglucose\tmetabolism\tand\tits\nvarious\tcauses\thelps\tdefine\tthe\tcomplex\tcondition\tof\tprolonged\tinflammation\t(\nPatel\tan... | [
-0.04778604954481125,
-0.08906291425228119,
0.06125544384121895,
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0.046745385974645615,
0.07125517725944519,
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-0.006985433865338564,
0.0569... |
).\nBiochemical\tmarkers\talso\tcan\tbe\timportant\tfactors\n\tin\tpersonalizing\tan\tindividual’s\t“total\ninflammatory\tload.”\tInflammatory\tmarkers\tsuch\tas\tsedimentation\trate\t(blood)\tare\tsignificant\tin\nmonitoring\tthe\tprogression\tof\tchronic\tinflammatory\tprocesses\t(see\t\nChapter\t5\n). | [
0.0021538464352488518,
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0.050482574850320816,
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0.08301086723804474,
0.07100564986467361,
-0.08814582973718643,
-0.039975110441446304,
0.06880... |
Chapter\t5\n).\nPredictive\tgenomic\ttesting\thas\tprovided\tnew\ttools\tfor\tpersonalizing\tassessment\tof\tindividual\nmetabolism.\tThe\tuse\tof\tSNP\ttesting\tis\tgrowing\tat\ta\trapid\tpace.\tIt\tis\timportant\tto\tappreciate\n\tthe\tSNP\nas\ta\t“predictive”\tvalue\tand\tnot\tas\ta\t“diagnostic”\ttool.\tAn\texample... | [
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0.08360190689563751,
0.08894164115190506,
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0.030372176319360733,
0.... |
association\tbetween\ta\tvitamin\tD\treceptor\tSNP\twith\tbreast\tcancer\t(VDR\tgenes\tsuch\tas\tCDX2\tand\nBGL)\t(\nKhan,\tM\tet\tal,\t2014\n).\tThe\tVDR\tgene\tmay\tinfluence\trisks\tof\tsome\tcancers\tand\ttheir\tprognosis.\nThis\tencourages\tcloser\tmonitoring\tof\tvitamin\tD\tstatus\tin\tcancer\tpatients\t(\nHuss\... | [
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0.12431281805038452,
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0.06116678938269615,
0.058... |
Huss\tet\tal,\t2019\n).\nVitamin\tD\n\tis\tinvolved\tin\tenhancing\tthe\tmanagement\tof\tmetabolic\tinflammation\tbecause\tof\tits\n“prohormone”\tand\timmune\tmodulating\teffects.\tThis\tcomprehensive\tcandidate-gene\tanalysis\ndemonstrates\tthat\tthe\trisk\tof\tmultiple\tVDR\tpolymorphisms\tresults\tin\tlower\tVDR\tmR... | [
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0.01207045279443264,
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0.016408344730734825,
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0.061285413801670074,
0.0825500413775444,
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0.011615005321800709,
-0.00... |
Polymorphisms\tof\tthe\tvitamin\tD\treceptor\tgene\t(VDR)\thave\tbeen\tshown\tto\tbe\tassociated\twith\tseveral\ncomplex\tdiseases,\tincluding\tosteoporosis.\tThis\n\tcould\taffect\tthe\tvitamin\tD\tsignaling\tefficiency\tand\nmay\tcontribute\tto\tthe\tincreased\tfracture\trisk\tin\tsome\tpopulations\t(\nZhang\tet\tal,... | [
0.022040432319045067,
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0.061056844890117645,
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0.05336619168519974,
0.015741189941763878,
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0.05255937576293945,
0.11702059209346771,
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0.034774... |
Zhang\tet\tal,\t2018a\n).\nGathering\tthe\tpatient’s\tstory\tand\tcombining\tit\twith\tother\tdata\tlike\tanthropometrics,\tmedical\nhistory,\tand\tthe\tnutrition\tfocused\tphysical\texamination\t(see\t\nAppendix\t11\n)\tallows\ta\tpattern\tto\temerge\nof\tnutritional\tand\tmetabolic\tpriorities.\tThis\tprovides\tthe\t... | [
0.0008130403584800661,
0.005542605649679899,
0.0694093257188797,
0.025447867810726166,
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0.12901662290096283,
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0.008608738891780376,
0.04... |
with\timportant\tinformation\tto\ndevelop\ta\tnutrition\tintervention\tto\tpromote\toptimal\thealth\tand\twellness.\nDevelopmental\tinflammatory-related\tconditions\nDevelopmental\tinflammatory-related\tconditions\tbring\ta\tfocus\tto\tthe\tuterine\tenvironment,\twhere\nthere\tis\trecognition\tof\tthe\timportance\tof\t... | [
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0.09400112181901932,
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0.08556729555130005,
0.09493133425712585,
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0.051... |
fetus\tcan\timpact\tlong-term\thealth\tand\trisk\tof\tdisease.\n\tIn\tthe\tinfant\tand\ttoddler\tyears,\tnegative\nphysical\tand\tpsychosocial\texposures,\tincluding\tviolence,\tabuse,\tbullying\tand\tracism,\tcan\talso\ninfluence\thealth\tinto\tadulthood.\tIf\tthe\tfetus\tand\tyoung\tchild\tdo\tnot\tgrow\tin\ta\thealt... | [
0.009081253781914711,
0.011923140846192837,
0.056358061730861664,
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0.025929588824510574,
0.09068356454372406,
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0.12145131081342697,
0.10609043389558792,
-0.08154896646738052,
-0.013510297052562237,
-0.0... |
the\tinflammatory\tprocesses\tof\tchronic\tdisease\ttake\troot\tand\twill\tchallenge\tthe\tindividual\tthroughout\ntheir\tlife\t(\nClaycomb\tet\tal,\t2015\n;\t\nEFCNI,\t2015\n;\t\nLane,\t2014\n;\n\tsee\t\nChapters\t15\n\tand\t\n16\n).\nSummary\nChronic\tdisease\tis\tan\tepidemic\tthat\tis\taffected\tby\tdiet\tand\tlife... | [
0.006312597543001175,
-0.022493792697787285,
0.05698796361684799,
-0.04758007451891899,
-0.11335251480340958,
0.0213468074798584,
0.08682598918676376,
-0.022182883694767952,
0.021164225414395332,
0.06882742047309875,
0.11448802053928375,
-0.0695437639951706,
0.0008086886373348534,
0.056200... |
pathophysiology\tis\tthe\tresult\tof\tgenetics\tand\tepigenetic\tinfluences.\tSustained\tinflammation\tis\tthe\ncommon\tdenominator\tin\tmost\tchronic\tdisease.\tNutrition\tand\tlifestyle\tare\tmodulators\tof\tsustained\ninflammation\t(\nBox\t7.6\n).\nBOX\t7.6 | [
0.0136543745175004,
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0.05610958859324455,
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0.07343326508998871,
0.029530411586165428,
0.021547861397266388,
0.07721584290266037,
0.07223853468894958,
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-0.07849912345409393,
0.070272780... |
Food,\tNutraceuticals,\tand\tLifestyle\tas\n\t\nMedicine\tto\tManage\nInflammation\nFood\nWhole\tFoods\tDiet\nMediterranean\tDiet\nMed-Asian\tDiet\nNordic\tDiet\nFruits\tand\tvegetables\nBeneficial\tfats\nPure\twater\nTargeted\tnutrients\nLow-antigen\tfoods\tfor\tthe\tindividual\nLow\ttoxin–containing\tfoods | [
0.004106211941689253,
-0.03668486699461937,
0.0463450625538826,
0.014747262001037598,
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0.035734064877033234,
0.09557592123746872,
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0.17017419636249542,
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-0.0... |
Low-antigen\tfoods\tfor\tthe\tindividual\nLow\ttoxin–containing\tfoods\nFoods\tand\tcookware\ttoxin-free\t(aluminum,\tBPA,\tperfluorooctanoic\tacid\t[PFOA]-free)\nNutraceuticals\nQuercetin\nRutin\nCurcumin\nProteolytic\tenzymes\nEnzyme\ttherapy\nRx\tnutrition\ttherapy\nGuidance\tfor\tdietary\tsupplements\nLifestyle\nSl... | [
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0.033275194466114044,
0.16162636876106262,
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0.008405664935708046,
0.0... |
Lifestyle\nSleep\nPhysical\tactivity\nBeliefs\nCommunity\nThe\tnutritionist\thas\tan\timportant\trole\tin\tthe\tinterdisciplinary\tmanagement\tof\tchronic\tdisease.\nHaving\tthe\tskills\tto\trecognize\tearly\tsigns\tand\tsymptoms\tof\tinflammation\tenable\tthe\tnutritionist\tto\nidentify\tnutritional\tpriorities\tand\t... | [
0.05648176372051239,
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0.05944105610251427,
0.056663841009140015,
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0.016112983226776123,
0.11113516986370087,
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0.07459957897663116,
0.10212269425392151,
-0.05102456733584404,
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0.0035... |
identify\tnutritional\tpriorities\tand\tindividual\tstrategies\n\tto\treduce\tinflammation\tand\trestore\thealth\tand\nwell-being.\nWhole\tfoods,\t“functional\tfoods,”\ttargeted\tdietary\tsupplements\twhen\tindicated,\tand\tlifestyle\nchanges\tcan\tbe\tfoundational\tin\tachieving\twellness.\tDietitians\twith\tan\tunder... | [
0.041189540177583694,
0.010909505188465118,
0.0643569827079773,
0.024187816306948662,
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0.006925029680132866,
0.1294713169336319,
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0.0406070277094841,
0.1190962865948677,
-0.11060342192649841,
-0.01910773478448391,
0.0102086076... |
and\tinflammatory\tresponse\tand\tits\trelationship\tto\tchronic\tdisease\twill\thave\tthe\tcapacity\tfor\tmore\neffective\tnutrition\tassessments\tand\tinterventions.\nUseful\twebsites\nAmerican\tAcademy\tof\tSleep\tMedicine\nAngiogenesis\tFoundation\nDietitians\tin\tIntegrative\tand\tFunctional\tMedicine\nInflammatio... | [
0.04104313999414444,
-0.046253908425569534,
0.04798676446080208,
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0.00775559525936842,
0.10404108464717865,
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0.025580106303095818,
0.08525247126817703,
0.08442811667919159,
-0.06210208684206009,
0.01704527623951435,
0.0169125... |
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