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•\t\nB\tComplex\t(B1-B2-B3-B5-B6-B9\t(folate)-B12-Biotin-Choline)\n•\t\nAntioxidants\t–\treactive\toxygen\tspecies\t(ROS)\n•\t\nAlbumin\t–\tglobulin\nSystem\tpartners\tand\trhythm\tcycles:\n•\t\nAutonomic\tNervous\tSystem:\tsympathetic\t–\tparasympathetic\n•\t\nCircadian\tRhythm:\t24-hour\tbalanced\trhythm\n•\t\nAcid-B... | [
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•\t\nCircadian\tRhythm:\t24-hour\tbalanced\trhythm\n•\t\nAcid-Base\tBalance\n•\t\nMicrobiome:\toral,\tnasal,\tskin,\tlung,\tvaginal,\tgastrointestinal\n•\t\nHormones-biochemistry\n•\t\nCortisol\t–\tinsulin\t–\tglucose\n•\t\nEstrogen\t–\tprogesterone\t–\ttestosterone\n•\t\nT4-T3\t(total\tand\tfree\tforms)\n•\t\nHPTA\tax... | [
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–\tThyroid\t–\tAdrenal\nTriage\ttheory\nThe\tconcept\tof\tnutrient\t\ntriage\ttheory\n\tstates\tthat\t“during\tpoor\tdietary\tsupply,\tnutrients\tare\npreferentially\tutilized\tfor\tfunctions\tthat\tare\timportant\tfor\tsurvival.”\tAs\ta\tconsequence,\tsome\ttissues\nmay\tbe\tlacking\tduring\ttimes\tof\tinsufficiency.\... | [
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nutrients/cofactors\ttriggers\ta\tbuilt-in\trationing\n\tmechanism\tthat\tfavors\tthe\tproteins\tneeded\tfor\nimmediate\tsurvival\tand\treproduction\t(survival\tproteins)\twhile\tsacrificing\tthose\tneeded\tto\tprotect\nagainst\tfuture\tdamage\t(longevity\tproteins).\tImpairment\tof\tthe\tfunction\tof\tlongevity\tprote... | [
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in\tan\tinsidious\tacceleration\tin\tthe\trisk\tof\tdiseases\tassociated\twith\taging.\tThis\tmay\tresult\tin\ta\tchronic\ndeficiency\tin\tthe\tperson\twith\tinadequate\tnutrient\n\tintake\tthat\toccurs\tfor\tyears\tand\toften\tfor\tdecades\n(\nAmes,\t2006\n;\t\nAmes,\t2010\n;\t\nMcCann\tand\tAmes,\t2011\n).\nTo\tsumma... | [
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;\t\nMaggio\tet\tal,\t2014\n):\n•\t\nMost\ttissues\tneed\tmost\tnutrients.\n•\t\nInadequate\tintakes\tof\tmost\tnutrients\timpair\tthe\tfunction\tof\tmost\tsystems.\n•\t\nThe\tclassical\tdeficiency\tdiseases\toccur\tat\tonly\tthe\textremes\tof\t“inadequacy”\t(see\t\nFig.\t5.2\n\tin\nChapter\t5\n).\n•\t\nThe\trole\tof\t... | [
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status\tas\ta\tkey\tfactor\tof\tsuccessful\taging\tis\tvery\twell\trecognized\n(\nMcCann\tand\tAmes,\t2011\n).\n•\t\n“Adequate”\tadult\tnutrition\tcan\tbe\tbest\tconceptualized\tas\tpreventive\tmaintenance. | [
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Inflammation:\tCommon\tdenominator\tof\tchronic\tdisease\nInflammation\tis\tthe\tnatural,\treaction\tof\ta\thealthy\timmune\tsystem\tas\tit\tresponds\tto\tinjury\tor\ninfection,\tor\tflight\tor\tfright\tscenarios.\tSee\t\nBox\t7.2\n\tfor\ta\tclassic\n\tdescription\tof\tinflammation.\nBOX\t7.2\nThe\tFive\tClassic\tSigns... | [
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BOX\t7.2\nThe\tFive\tClassic\tSigns\tof\tInflammation,\tFirst\tDescribed\tand\nDocumented\tby\tAulus\tCornelius\tCelsus\t(ca\t25\tBC-ca\t50),\ta\nRoman\tPhysician\tand\tEncyclopaedist\n•\t\nDolor\n\t-\t“pain”\n•\t\nCalor\n\t-\t“heat”\n•\t\nRubor\n\t-\t“redness”\n•\t\nTumor\n\t-\t“swelling”\n•\t\nFunctio\tlaesa\n\t-\t“in... | [
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•\t\nFunctio\tlaesa\n\t-\t“injured\tfunction”\tor\t“loss\tof\tfunction.”\nThe\timmune\tsystem’s\tresponse\tto\tphysiologic\tand\tmetabolic\n\tstress\tis\tto\tproduce\tproinflammatory\nmolecules\tsuch\tas\t\nadipokines\n\tand\t\ncytokines\n.\tThese\tcell-signaling\tmolecules\taid\tin\tcell-to-cell | [
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and\t\ncytokines\n.\tThese\tcell-signaling\tmolecules\taid\tin\tcell-to-cell\ncommunication\tand\tstimulate\tthe\tmovement\tof\tcells\ttoward\tsites\tof\tinflammation\tin\tconditions\tof\ninfection\tand\tinjury.\tThus\tthe\timmune\tsystem\tresponds\tand\tthe\tresulting\tinflammation\tis\tintimately\nconnected.\nAccordi... | [
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connected.\nAccording\tto\tUndurti\tN\tDas,\tMD,\tin\tthe\tMolecular\tBasis\tof\n\tHealth\tand\tDisease:\nInflammation\tis\tthe\tcomplex\tbiological\tresponse\tof\tvascular\ttissue\tto\tharmful\tstimuli\tsuch\tas\tpathogens,\ndamaged\tcells\tor\tirritants\tthat\tconsists\tof\tboth\tvascular\tand\tcellular\tresponses.\t... | [
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protective\tattempt\tby\tthe\torganism\tto\tremove\tthe\tinjurious\tstimuli\tand\tinitiate\tthe\thealing\tprocess\tand\nto\trestore\tboth\tstructure\tand\tfunction.\tInflammation\tmay\tbe\tlocal\n\tor\tsystemic.\tIt\tmay\tbe\tacute\tor\nchronic.\nOptimally,\tthe\timmune\tsystem’s\tfunction\tis\tto\tkeep\tthe\tbody\thea... | [
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an\tinflammatory\tresponse\tto\tenvironmental\tinfluences,\tsuch\tas\tshort-lived\tinfection\tand\tinjury,\tand\nthen\treturning\tthe\tbody\tto\tan\talert\tsystem\tof\tdefense.\tThis\tfunction\tdepends\ton\tthe\tbody’s\tability\tto\nrecognize\t“self”\tand\t“nonself.”\tWhen\tthe\timmune\tresponse\n\tis\tsuccessful,\tthe... | [
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is\tsuccessful,\tthe\ttissue\treturns\tto\ta\tstate\nof\twellness,\tor\tmetabolic\tstability\tdescribed\tas\tallostasis.\tIf\tmany\tareas\tof\tthe\tbody’s\tdefense\tsystem,\nsuch\tas\tthe\tgastrointestinal\tbarrier,\tstomach\tacidity,\tskin,\tor\tvarious\torifices\t(e.g.,\teye,\tear,\tnose, | [
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lung,\tvagina,\tuterus),\tare\tcompromised,\tthere\tis\tdiminishing\trecognition\tof\t“self”\tand\t“nonself”\tuntil\nthe\tbody\tis\trepaired.\tThe\tlonger\tthe\tphysiologic\n\tinjury\tcontinues,\tthe\tgreater\tthe\tloss\tof\tthe\tability\tto\nrecognize\t“self”\tand\t“nonself”\t(\nFasano,\t2012;\tWu\tet\tal,\t2014\n). | [
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recognize\t“self”\tand\t“nonself”\t(\nFasano,\t2012;\tWu\tet\tal,\t2014\n).\nIf\tthe\tunderlying\tcause\tis\tnot\tresolved,\tthe\timmune\tresponse\tcan\tget\t“stuck”\tin\ta\tstate\tof\nprolonged\tinflammation.\tLocked\tinto\tthis\tstate\tfor\ta\twhile,\tthe\timmune\tsystem\tloses\tits\tability\tto\nrecognize\t“self”\ta... | [
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Gonzalez\tet\tal,\n2011\n;\t\nPaul,\t2010\n).\nProlonged\tinflammation\nProlonged\tinflammation\n,\tknown\tas\tchronic\tinflammation,\tsustained\tinflammation,\tor\tnonresolving\ninflammation,\tleads\tto\ta\tprogressive\tshift\tin\tthe\ttype\tof\tcells\tpresent\tat\tthe\tsite\tof\tinflammation\tand | [
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is\tcharacterized\tby\tsimultaneous\tdestruction\tand\thealing\tof\tthe\ttissue\tfrom\tthe\tinflammatory\nprocess.\tMultiple\tstudies\thave\tsuggested\tthat\tprolonged\tinflammation\n\tplays\ta\tprimary\trole\tin\tthe\npathogenesis\tof\tchronic\tdiseases\t(e.g.,\tcardiovascular\tdisease,\tcancer,\tdiabetes),\twhen\tthe... | [
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response\tis\tto\tincrease\tthe\tratio\tof\tproinflammatory\tto\tantiinflammatory\tcytokines\t(\nBauer\tet\tal,\n2014\n;\t\nFranceschi\tand\tCampisi,\t2014\n).\nIn\tthe\tchronology\tof\tchronic\tdisease\tprogression,\tinflammation\tis\tat\tfirst\tsubclinical,\toften\treferred\nto\tas\t“silent\tinflammation.”\tThis\n\ti... | [
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insidious\tinflammation\tremains\tbelow\tthe\tthreshold\tof\tclinical\ndiagnosis.\tCellular\tand\ttissue\tdamage\tcan\toccur\tin\tthe\tbody\tfor\tyears\tbefore\tbeing\tnoticed.\tIt\tis\tlike\na\t“smoldering”\tfire\twith\ta\tsmall\twhiff\tof\tsmoke\tand\theat\tbeing\tevident\tbefore\tit\tfinally\tbursts\tinto\ta\nflame.... | [
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Noland,\t2013\n).\tInflammation\nin\tchronic\tdisease\tis\tdescribed\n\tas:\nLow-grade,\tchronic,\tsystemic\tinflammation\tmay\tbe\tdefined\tas\ta\t2-\tto\t3-fold\televation\tof\tcirculating\ninflammatory\tmediators,\tusually\tassociated\twith\tthe\tinnate\tarm\tof\tthe\timmune\tsystem.\tIt\tis\ta\tstate\tthat | [
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develops\tslowly\t(in\tcontrast\tto\tpathologic\tacute\tinflammatory\tresponses,\tto\tsepsis\tfor\texample),\tand\tits\norigin\tcannot\tbe\teasily\tidentified\t(in\tcontrast\tto\tchronic\tinflammatory\tdiseases\n\tsuch\tas\trheumatoid\narthritis\tand\tinflammatory\tbowel\tdisease,\twhere\tadditional\tsymptoms\tidentify... | [
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inflammation).\tThis\tmakes\tit\tdifficult\tto\tdevelop\tappropriate\ttherapeutic\tstrategies\tthat\ttarget\tboth\ncause\tand\tsymptom\t(inflammation)\tin\ta\tconcerted\tfashion\t(\nCalçada\tet\tal,\t2014\n).\nOf\tconcern\tis\tthe\tinitiation\tof\tprolonged\tinflammation\tin\tutero\tfrom\tthe\tmaternal\tinflammatory\ne... | [
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environment,\n\tthereby\tprogramming\tthe\tfetus\tfor\ta\tlifetime\tof\tchronic\tdisease\t(\nEuropean\tFoundation\nfor\tthe\tCare\tof\tNewborn\tInfants\t[EFCNI],\t2015\n;\t\nLane,\t2014\n;\t\nFisher\tet\tal,\t2012\n;\t\nFleisch\tet\tal,\t2012\n;\nsee\t\nChapter\t14\n). | [
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0.02... |
Inflammation\tis\ta\tvery\tcomplex\tcondition,\tand\tthere\tare\tmany\tprotein\tbiomarkers\tthat\tare\tacute\nphase\treactants.\tClinical\televations\tof\tinflammatory\tbiomarkers,\tsuch\tas\tCRP-hs\t(plasma),\nsedimentation\trate\n,\t\ninterleukin-6\t(IL-6)\n,\tand\t\ntumor\tnecrosis\tfactor\talpha\t(TNF-α)\n,\trepres... | [
-0.030368223786354065,
-0.05526822432875633,
0.031664300709962845,
-0.016780739650130272,
-0.05419934168457985,
0.06440435349941254,
0.05151452496647835,
0.11881048232316971,
-0.0005277973832562566,
0.08800587058067322,
0.009664474986493587,
-0.012967199087142944,
0.04184328764677048,
0.06... |
,\tand\t\ntumor\tnecrosis\tfactor\talpha\t(TNF-α)\n,\trepresent\nsystemic\tmarkers\tof\tinflammation\tthat\tare\texacerbated\tby\tinsulin\tresistance\t(IR)\tand\nhyperinsulinemia\n\t(\nDas,\t2010,\t2011\n;\tsee\t\nTable\t7.1\n).\tDiseases\tassociated\twith\tincreased\tlevels\tof\ninflammatory\tmarkers\tinclude\theart\t... | [
-0.02006801962852478,
-0.07661443203687668,
0.022100703790783882,
-0.008222775533795357,
-0.05819912999868393,
0.02754986844956875,
0.08390512317419052,
0.09875894337892532,
-0.024700213223695755,
0.0784594938158989,
0.04064060002565384,
0.013741490431129932,
0.031180741265416145,
0.083638... |
autoimmune\n\tdiseases,\tand\tpossibly\tcancer\nand\tAlzheimer’s\tdisease\t(\nBirch\tet\tal,\t2014\n;\t\nLuevano-Contreras\tet\tal,\t2017\n;\t\nWu,\t2013\n).\tSee\t\nTables\t7.2\nthrough\t\n7.4\n\tand\t\nBoxes\t7.3\n\tand\t\n7.4\n\tfor\tmore\texamples\tof\tcommon\tdisease\tspecific\tbiomarkers.\nTABLE\t7.1\nBiomarkers\... | [
-0.05543392524123192,
-0.06146343797445297,
0.04492214694619179,
-0.015621360391378403,
-0.06159580498933792,
0.03824009373784065,
0.10389284789562225,
0.09430570155382156,
-0.03120247833430767,
0.026329314336180687,
0.07205583155155182,
-0.04205922409892082,
0.0029063657857477665,
0.05718... |
Test\nReference\nAssociation\nBlood\tSpecimen\n8-hydroxy-2-\ndeoxyguanosine\n<\t7.6\tng/mL\nDNA\tincreased\tROS\tand\tcell\tproliferation\n*\nAsymmetric\ndimethylarginine\n(ADMA)\n<18\tyears:\tnot\nestablished\n≥18\tyears:\t63-137\nng/mL\nInhibitor\tof\tl-arginine\t(Arg)-derived\tnitric\toxide\n(NO)\nC-reactive\tprotei... | [
-0.0991043895483017,
-0.06408650428056717,
-0.01990470290184021,
-0.034001149237155914,
-0.0009670568397268653,
-0.035229068249464035,
0.01516726240515709,
0.0660582184791565,
-0.06742337346076965,
0.06158667802810669,
0.122107595205307,
-0.05111870542168617,
-0.03357351943850517,
0.065302... |
(NO)\nC-reactive\tprotein\nsensitivity\n≤3.0\tmg/L\nSystemic\tinflammation\trelated\tto\tbacterial\ninfection,\ttrauma,\tVAT,\tneoplastic\tactivity\nCA-125\n0-35\tU/mL\nInflammation\tin\tabdomen\nOvarian\tcancer\nUterine\tfibroids\nCA\t15-3/CA\t27-29\n<32\tU/mL\nBreast\tcancer,\tadvanced\nCA-19-9\nCarbohydrate\tAg\t19-... | [
-0.023574573919177055,
-0.08498519659042358,
-0.06701045483350754,
-0.00334226549603045,
-0.07093049585819244,
-0.02648666873574257,
0.05693366751074791,
0.15342949330806732,
-0.03741595521569252,
0.06361608952283859,
0.07285141199827194,
-0.02423897013068199,
-0.009826337918639183,
0.1015... |
(screening\ttest)\n<55\tU/mL\nUp\tto\t20%\tof\nindividuals\tdo\tnot\nexpress\tCA\t19-9.\nPancreatic\tcancer\nInfections\tin\tliver,\tgallbladder,\tand\tpancreas.\nCEA\n(other\tspecimens\talso)\n12-100\tyears:\t0-5.0\nng/mL\nCancer\nCD4\tLymphocyte\nCD4%\nHIV\tinfections,\tautoimmune\nCD8\tCount\nInfections\nLymphoma\nC... | [
0.04490035027265549,
-0.04006379842758179,
-0.056842342019081116,
-0.057895250618457794,
-0.08789371699094772,
-0.05489148199558258,
0.0704328641295433,
0.12680362164974213,
-0.054425474256277084,
0.06442666053771973,
0.06252928078174591,
-0.014913261868059635,
0.032441847026348114,
0.0824... |
Ceruloplasmin\n(bound\tcopper/\tacute\nphase\treactant)\n18-46\tmg/dL\nAcute\tphase\treactant\nCancer\t(elevated)\nWilson’s\tDisease\t(low)\nMenkes\n\tsyndrome\t(low)\nEosinophils\n1%-4%\nElevated\tinflammatory\tmarker\tof\tallergies\t/\nsensitivities,\thelminthic,\tparasites,\tautoimmune,\nneoplasms\nFerritin\t(storag... | [
0.006116852164268494,
-0.09102236479520798,
0.014906653203070164,
-0.0018280136864632368,
-0.06972504407167435,
-0.025333933532238007,
0.03898077830672264,
0.18962888419628143,
-0.026233049109578133,
0.04052858054637909,
0.08144707977771759,
-0.051113251596689224,
0.07260703295469284,
0.10... |
Males\t≥5\tyears:\t24-\n150\tng/mL\nFemales\t≥5\tyears:\t12-\n150\tng/mL\nAcute\tPhase\tReactant\nHemochromatosis\t(genetic)\nIron\tToxicity\nFibrinogen\t/\tPlatelets\n150-450\tmg/dL\t/\t150-\n450\tbillion/L\nDisseminated\tintravascular\tcoagulation\n\t(DC)\nLiver\tdisease\nHomocysteine\t(Hcy)\n0-15\tµmol/L\nBlock\tin\... | [
-0.015486633405089378,
-0.07190056890249252,
-0.03565279394388199,
-0.026866260915994644,
-0.07801316678524017,
-0.034597255289554596,
-0.0249800868332386,
0.11363492906093597,
-0.06961024552583694,
0.03350503742694855,
0.08363722264766693,
-0.016673974692821503,
0.010557718575000763,
0.08... |
cystathionine\trelate\tto\tB\n6\n,\tB\n12\n,\tfolate,\tbetaine\ncofactors\nIgA\tTotal\tor\tIgA\nspecific\n50-350\tmg/dL\nElevated\tin\tlymphoproliferative\tdisorders;\tchronic\ninfections;\tautoimmune;\tceliac\tdisease\nIgE\tTotal\tor\tIgE\nspecific\n800-1500\tmg/dL\nElevated\timmediate-response\tinflammatory\nallergic... | [
-0.0632658526301384,
-0.07603468745946884,
0.009260794147849083,
-0.08086897432804108,
-0.10176840424537659,
-0.007435493171215057,
0.05147254094481468,
0.12207601964473724,
-0.05867037922143936,
0.04011527821421623,
0.08085978031158447,
-0.029811648651957512,
0.06325319409370422,
0.058884... |
allergic\tdisorders;\tparasitic\n\tinfections\nIgG\tTotal\tor\tIgG\nspecific\n800-1500\tmg/dL\nElevated\tinflammation\tmarker\tof\tdelayed\nsensitivities;\tchronic\tinfections\nInterleukin-1\t(IL-1)\n<3.9\tpg/mL\nBone\tformation,\tinsulin\tsecretion,\tappetite\nregulation,\tfever\treduction,\tneuronal\ndevelopment\nInt... | [
-0.024839473888278008,
-0.022400517016649246,
0.06454399228096008,
-0.04999379813671112,
-0.035652924329042435,
-0.0028222473338246346,
0.037340570241212845,
0.17976534366607666,
-0.07366753369569778,
0.045950859785079956,
0.039101455360651016,
-0.017654620110988617,
0.06557230651378632,
0... |
development\nInterleukin\t8\t(IL-8)\n<17.4\tpg/mL\n<\tor\t=\t5\tpg/mL\n(2014)\nNeoplasms\t/\tpromotes\tangiogenesis\nObesity\nOxidative\tstress\nInsulin\t(Korkmaz,\n2014)\n2.0-12.0\tµlU/mL\nElevated\tinflammatory\tinsulin\tresistance\nLipid\tPeroxides\n<2.60\tnmol/mL\nInflammatory\televation\twhen\trisk\tof\toxidative\... | [
-0.055003583431243896,
-0.07592858374118805,
-0.001267578569240868,
-0.00805623084306717,
-0.040474992245435715,
-0.000777411216404289,
-0.00906867254525423,
0.16491708159446716,
-0.021626174449920654,
0.038994744420051575,
0.07616297900676727,
-0.011126194149255753,
-0.02284223400056362,
... |
Liver\tenzyme:\tALT\n0-35/U/L\nInflammatory\televation\tin\tliver\tdisease\nLiver\tenzyme:\tAST\n0-35\tU/L\nInflammatory\televation\twith\tliver,\tkidney,\tmuscle\ninfection,\tor\tinjury\nLiver\tenzymes:\tAlk\nPhos\n30-120\tU/L\nInflammatory\n\televation\trelated\tto\tliver,\tbone,\nplacenta\nLiver\tenzyme:\tGGT\n0-30\... | [
-0.026928288862109184,
-0.09424658119678497,
0.030867688357830048,
-0.07530832290649414,
-0.0823129341006279,
-0.05429932475090027,
0.08130153268575668,
0.06592392921447754,
-0.07885241508483887,
0.009918313473463058,
0.11061237752437592,
-0.06789791584014893,
0.009252834133803844,
0.06804... |
Elevated\tinflammatory\tmarker\tof\tliver\tdisease,\nneoplasms,\ttoxicity\nLiver\tenzyme:\tLDH\n50-150\tU/L\nProstate\tSpecific\nAntigen\t(PSA)\nTotal\tPSA\t≤4.0\tng/mL\n%\tFree\tPSA\t>25\t%\n(calc)\nProstate\tinflammation\nProstate\tcancer\nRheumatoid\tFactor\n(RF)\nLess\tthan\t40-60\tU/mL\nLess\tthan\t1:80\t(1-80)\nt... | [
0.008575363084673882,
-0.042838435620069504,
-0.037440188229084015,
0.029686816036701202,
-0.048339392989873886,
-0.0339387021958828,
-0.008979243226349354,
0.16633349657058716,
-0.042321622371673584,
0.058809179812669754,
-0.003481865394860506,
0.00008565908501623198,
0.0671824961900711,
... |
titer\nRheumatoid\tarthritis\nSjogren’s\nAutoimmune\tdisease\nSedimentation\tRate\n(ESR)\nWestergren\nMale\t<50\tyears\told:\n<15\tmm/hr\nMale\t>50\tyears\told:\n<20\tmm/hr\nFemale\t<50years\told:\n<20\tmm/hr\nFemale\t>50\tyears\told:\n<30\tmm/hr\nSystemic\tinflammation\tmarker\trelated\tto\nautoimmune;\tviral\tinfecti... | [
0.011171882972121239,
0.011095232330262661,
0.019988037645816803,
-0.002677659969776869,
-0.06256517022848129,
-0.013084321282804012,
0.013259762898087502,
0.13473904132843018,
-0.050778377801179886,
0.05676400661468506,
0.05090014636516571,
0.010667756199836731,
0.06317660212516785,
0.050... |
carcinoid\tinfluence\nTotal\tProtein\n60-80\tg/L\t(6.0-8.0\ng/dL)\nTotal\tprotein\tin\tserum\nAlbumin\n35\t-\t50\tg/L\t(3.5-5.0\ng/dL)\n(half-life\t∼\t20\tdays)\nAcute\tphase\treactant\nGlobulin\n2.6-4.6\tg/dL\nChronic\tinflammation,\tlow\talbumin\tlevels,\tand\nother\tdisorders\nTH17\nInterleukin\t17\t(IL-17)\n0.0-1.9... | [
-0.03099597990512848,
-0.048597656190395355,
-0.005518811754882336,
-0.06876484304666519,
-0.025440625846385956,
-0.01504063606262207,
0.05705384537577629,
0.11816232651472092,
-0.008442303165793419,
0.03964987397193909,
0.0891476720571518,
-0.03608491271734238,
0.04036844149231911,
0.0627... |
Fungal,\tbacterial,\tviral\tinfections,\tautoimmune\nconditions\nTNF-α\n1.2-15.3\tpg/mL\nSystemic\tinflammation\nAcute\tphase\treactant\nAlzheimer’s,\tinfection,\tdepression,\tIBD,\tcancer\nUric\tAcid\n2-7\tmg/dL\nAntioxidant,\n\televated\tin\tabnormal\turate\tcycle\nexacerbated\tby\tprotein\tin\tdiet,\tgout,\tother\nV... | [
-0.04389534145593643,
-0.07161320000886917,
-0.025680091232061386,
-0.09062634408473969,
-0.00769732054322958,
0.0035994781646877527,
0.03070719726383686,
0.05345028638839722,
-0.031417686492204666,
0.06904046982526779,
0.12843045592308044,
-0.07340168952941895,
0.008139990270137787,
0.074... |
VEGF\n31-86\tpg/mL\nCancer,\tangiogenesis\nWhite\tblood\tcell\tcount\n4.5-\t11\tx\t10\n3\n/µL\n(Elevated)\tLeukocytosis,\tbacterial\tinfections,\nanemia,\tcigarette\tsmoking\n(Low)\tCancer,\tradiation,\tsevere\tinfection\nStool\tSpecimen\nCalprotectin\n2-9\tyears\t166\tµg/g\tof\nfeces\n10-59\tyears\t51\tµg/g\tof\nfeces... | [
-0.057180847972631454,
-0.07336363941431046,
-0.03693636506795883,
-0.030306287109851837,
-0.03271929919719696,
-0.05178053304553032,
0.01548012439161539,
0.1582263857126236,
-0.08296318352222443,
0.0507156178355217,
0.06348782032728195,
-0.009740250185132027,
0.003065693425014615,
0.05117... |
feces\n≥\t60\tyears\t112\tµg/g\nof\tfeces\nInflammatory\tbowel\tdisease\nIntestinal\tinflammation\nNeoplasms\nLactoferrin\nNegative\nIntestinal\tinflammation\nPancreatic\telastase\tI\n>\t200\tµg/g\nExocrine\tpancreatic\tfunction\nUrine\n5-\nhydroxyindoleacetate\n(5-HIAA)\n1.6-10.9\tµg/mL\ncreatinine\nElevated\twith\tin... | [
-0.007405193522572517,
-0.11508267372846603,
0.001317489193752408,
-0.00037633784813806415,
-0.12366504967212677,
-0.023746682330965996,
0.03299695625901222,
0.10833030939102173,
-0.04852692410349846,
0.046388860791921616,
0.04445885866880417,
0.02875843085348606,
-0.0016092006117105484,
0... |
serotonin\np-\nhydroxyphenyllactate\n(HPLA)\n<1.45\tµg/mL\ncreatinine\nInverse\trelationship\tto\n\tdepletion\tof\tascorbic\tacid\n*\nNormal\tvalue\tranges\tmay\tvary\tslightly\tamong\tdifferent\tlabs\nTABLE\t7.2\nAutoimmune\tSpecific\tInflammatory\tMarkers\nBiomarker\tTest\nReference\nRange\nSpecimen\nAssociation\nSed... | [
0.020098190754652023,
-0.14608758687973022,
0.020955383777618408,
0.003713538171723485,
-0.13464835286140442,
0.03240324556827545,
0.05068802088499069,
0.07924684882164001,
-0.019680969417095184,
0.05604204908013344,
0.029450086876749992,
-0.022837361320853233,
0.001973421312868595,
0.0387... |
Sedimentation\tRate\n(ESR)\nMen:\t0-15\tmm/h\nWomen:\t0-20\nmm/h\nBlood\nserum\nCollagen\tdiseases\nInflammatory\tdiseases\nInfections\nToxicity,\theavy\tmetals | [
-0.007134987507015467,
-0.10232782363891602,
0.024566147476434708,
-0.04262220859527588,
-0.02393515408039093,
-0.032936159521341324,
0.05797308310866356,
0.11808092892169952,
-0.024345815181732178,
0.01234287116676569,
0.05559035763144493,
-0.07288139313459396,
-0.03256357088685036,
0.070... |
C-Reactive\tProtein-\nhs\t(CRP-hs)\n<1.0\tmg/dL\nBlood\nSystemic\tinflammation\nMetabolic\tSyndrome\nRheumatoid\tFactor\n(RF)\n0-39\tIU/mL\nnonreactive\n40-79\tIU/mL\nweakly\nreactive\n>80\n\treactive\nBlood\nRheumatoid\tarthritis\nSjögren’s\tsyndrome\nJoint\tpain\nRheumatoid\tconditions\nAntigliadin\tAntibody\nDeamida... | [
-0.006853062193840742,
-0.047564905136823654,
-0.007956488057971,
0.034156277775764465,
-0.07345188409090042,
-0.015094463713467121,
-0.020857878029346466,
0.15899138152599335,
-0.06325744837522507,
0.06477990001440048,
-0.037350237369537354,
0.033554550260305405,
0.05545629933476448,
0.03... |
Antibody,\tIgA,\nIgG\n0-19\tNegative\n20-30\tWeak\nPositive\n>30\tModerate\tto\nStrong\npositive\nBlood\nserum\nCeliac\tdisease\nDermatitis\therpetiforme\nNon-Celiac\tgluten\tsensitivity\nEndomysial\tantibody\ntest\t(IgA-EMA)\nNegative\tnormal\nindividuals\nNegative\tGluten-\nfree\n\tdiet\nDermatitis\therpetiforme,\tce... | [
0.0013367310166358948,
-0.08644446730613708,
-0.0015477898996323347,
-0.0252403374761343,
-0.10965320467948914,
-0.03655796870589256,
0.044521305710077286,
0.11587309837341309,
-0.06688819825649261,
0.06823454797267914,
0.06830131262540817,
-0.012342117726802826,
-0.0005403783870860934,
0.... |
Tissue\nTransglutaminase\nIgA/IgG\t(tTG-IgA)\n<4.0\tU/mL\n(negative)\n4.0-10.0\tU/mL\n(weak\npositive)\n>10.0\tU/mL\n(positive)\nReference\tvalues\napply\tto\tall\nages.\nBlood\nserum\nCeliac\tdisease\t(indicates\tRx\tbiopsy,\ngene\tHLA_DQ2/DQ8)\nDermatitis\therpetiforme\nVilli\tAtrophy\nSS-A\tSjögren’s/Ro\nIgG\n<1.0\t... | [
-0.0407295897603035,
-0.1079762876033783,
0.00961318053305149,
-0.03411240875720978,
-0.10951248556375504,
-0.04390925541520119,
0.009030435234308243,
0.1472138613462448,
-0.05119645968079567,
0.0768154188990593,
0.07726173102855682,
0.001985152019187808,
0.04509411379694939,
0.11617614328... |
(negative)\n>\tor\t=\t1.0\tU\n(positive)\nReference\tvalues\napply\tto\tall\nages.\nBlood\nConnective\ttissue\tdisease\t(Systemic\nlupus\terythematosus,\tSjögren’s,\nRheumatoid\tarthritis)\nSS-B\tSjögren’s\n<1.0\tU\n(negative)\n>\tor\t=\t1.0\tU\n(positive)\nReference\tvalues\napply\tto\tall\nages.\nBlood\nConnective\tt... | [
-0.041376084089279175,
-0.010959187522530556,
0.027385318651795387,
0.038016293197870255,
-0.10710122436285019,
0.034163523465394974,
-0.007080280687659979,
0.11897895485162735,
0.020096953958272934,
0.06078349053859711,
0.06310638785362244,
0.019540080800652504,
0.07962008565664291,
0.057... |
Sjögren’s\tsyndrome,\tsystemic\tlupus\nerythematosus\t(SLE)\nANA\tantibody\ttiter\n<1:40\tnormal\t(or\n<\t1/0\tIU)\tis\nnegative\nBlood\nserum\nMultiple\n\tautoimmune\tconditions,\nsystemic\tlupus\terythematosus\t(SLE)\nAnti-dsDNA\tTest\tIgG\n<30.0\tIU/mL\n(negative)\n30.0-75.0\tIU/mL\n(borderline)\n>75.0\tIU/mL\n(posi... | [
-0.013469433411955833,
-0.0587005577981472,
0.016143914312124252,
-0.0073169837705791,
-0.10162987560033798,
0.0025557298213243484,
-0.023819927126169205,
0.14940360188484192,
-0.05060669779777527,
0.06114912033081055,
0.08562867343425751,
-0.02248855121433735,
0.03312717005610466,
0.02557... |
Negative\tis\nconsidered\nnormal.\nReference\tvalues\napply\tto\tall\nages.\nBlood\nCyclic\tCitrullinated\nPeptide\tAntibody\n(Anti-CCP)\n<20.0\tU\n(negative)\n20.0-39.9\tU\n(weak\npositive)\n40.0-59.9\tU\n(positive)\n>\tor\t=\t60.0\tU\n(strong\npositive)\nReference\tvalues\napply\tto\tall\nages.\nBlood\nRheumatoid\tar... | [
0.00457624951377511,
-0.008213656954467297,
0.008503375574946404,
0.04500741511583328,
-0.08472184836864471,
0.00389255047775805,
0.0034230132587254047,
0.15899816155433655,
-0.03981584683060646,
0.04595204442739487,
0.08868899941444397,
0.017361657693982124,
0.05499288812279701,
0.0835995... |
Arthritis\nAnti-Desmoglein\t1/3\nIgG\tantibody\nBlister\tbiopsy\nnegative\nBlood\nSkin\ttissue\nPemphigus\tvulgaris\nPemphigus\tfoliaceus\nEpidermolysis\tbullosa\tacquisita | [
0.01824580691754818,
-0.05304032191634178,
0.011230659671127796,
0.05132635682821274,
-0.10467612743377686,
-0.027601074427366257,
0.06810745596885681,
0.015926625579595566,
-0.044377733021974564,
0.06576965749263763,
0.07569058984518051,
-0.039717018604278564,
0.026404058560729027,
0.0024... |
TABLE\t7.3\nNeurologic\tSpecific\tInflammatory\tMarkers\nBiomarker\tTest\nReference\nSpecimen\nAssociation\nRBC\tFatty\tAcid\nAnalysis\nMean\t+/−\tSD\nBlood\nMembrane\tintegrity\nLipid\tPanel\nTriglycerides\nTotal\tCholesterol\nHDL\nLDL\n170-200\tmg/dL\n50-80\tmg/dL\nMen:\t37-40\tmg/dL\nWomen:\t40-85\tmg/dL\nAdult\t<13... | [
-0.029513176530599594,
-0.10531887412071228,
-0.015090311877429485,
-0.013061766512691975,
-0.12165963649749756,
-0.07469897717237473,
0.020834000781178474,
0.125422403216362,
-0.04189245402812958,
-0.023059776052832603,
0.051331277936697006,
-0.06764036417007446,
0.019924787804484367,
0.0... |
mmol/L\nChild\t<110\tmg/dL\tor\t<2.8\nmmol/L\nBlood\nBlood\nBlood\nCHD\trisk\nAdult:\tCHD\trisk\nChild:\tabnormal\tcholesterol\nmetabolism\nCREATINE\tKINASE\nCreatinine\nBUN\nGFR\n0.76-1.27\tmg/dL\n8-27\tmg/dL\n>60\tmL/min/BSA\nBlood\nKidney\tfunction\nGlucose,\tfasting\n65-99\tmg/dL\nBlood,\nurine\nGlucose\tstatus\nIn... | [
-0.04775845631957054,
-0.11163006722927094,
-0.020846692845225334,
-0.005991681944578886,
-0.1317279189825058,
-0.06008736789226532,
-0.040967535227537155,
0.1350867748260498,
-0.06339016556739807,
-0.04445122554898262,
0.029725758358836174,
-0.07031647115945816,
0.04759546369314194,
-0.01... |
2.0-19.6\tµIU/mL\nBlood\nInsulin\tstatus\nHgbA1C\n4.8%-6.4%\nBlood\nAverage\tBS\tover\t120\tdays\n25OH\tvit\tD\n30-150\tng/mL\nBlood,\nsaliva\nVitamin\tD\tstatus\nTABLE\t7.4\nEndocrine\t(noncancer)\tSpecific\n\tInflammatory\tMarkers\nBiomarker\tTest\n(Mother)\nReference\nSpecimen\nAssociation\nRBC\tFatty\tAcid\tAnalysi... | [
-0.026979083195328712,
-0.16302290558815002,
-0.010583939962089062,
0.014898679219186306,
-0.07610350102186203,
-0.05707141011953354,
0.033845365047454834,
0.08879461139440536,
-0.061053723096847534,
-0.014852115884423256,
0.09959877282381058,
-0.09209296107292175,
-0.026777023449540138,
0... |
Mean\t+/−\tSD\nBlood\nMembrane\tintegrity\nLipid\tPanel\nTotal\tCholesterol\nHDL-chol\nLDL-chol\nTriglycerides\n170-200\tmg/dL\nMen:\t37-40\tmg/dL\nWomen:\t40-85\tmg/dL\nAdult\t<130\tmg/dL\tor\t<3.4\nmmol/L\nChild\t<110\tmg/dL\tor\t<2.8\nmmol/L\n<150\tmg/dL\nBlood\nCHD\nCholesterol/lipid\nmetabolism\nLiver\tstress\nCHD... | [
-0.01805942691862583,
-0.10746482759714127,
-0.007105693686753511,
0.018137747421860695,
-0.12459411472082138,
-0.11237824708223343,
-0.00434378907084465,
0.11144960671663284,
-0.045437417924404144,
-0.04621502384543419,
0.07564812153577805,
-0.053056906908750534,
-0.008495408110320568,
-0... |
CHD\trisk\nCHD\trisk\nAbnormal\tcholesterol\nMetabolic\tsyndrome\nCarnitine\tinsufficiency\nHigh\tsimple\nsugar/alcohol\tdiet\nCHD\trisk\nCeliac\tPanel\ntTG\tIgG/IgA\nAnti-Gliadin\tantibody\ntissue\tTransglutaminase\nIgG/IgA\n<4\tU/mL\tno\tantibody\ndetected\n<20\tUnits\tantibody\tnot\ndetected\nSmall\tintestine\tvilli... | [
-0.03449688106775284,
-0.05344708636403084,
-0.019707411527633667,
0.02723451517522335,
-0.09141842275857925,
-0.034238699823617935,
0.03839462623000145,
0.07793495804071426,
-0.06538984179496765,
-0.020545119419693947,
0.10199941694736481,
-0.06109774857759476,
-0.014066255651414394,
-0.0... |
Small\tintestine\tvilli\natrophy\nGluten\tsensitivity\nGluten-free\tdiet\nAntigen\t(Food\tIgG/IgE)\nPer\tlaboratory\nInsulin,\tfasting\n2.0-19.6\tμIU/mL\nBlood\nInsulin\tstatus\nHgbA1C\n4.8%-6.4%\nBlood\nAverage\tBS\tover\t120\ndays\nTSH\nAdult\t0.2-5.4\tmU/L\tblood\nBlood\nThyroid\tfunction\nVitamin\tD\n2\n5-OH\n30-15... | [
-0.03373196721076965,
-0.10435095429420471,
0.011525599285960197,
0.05054603889584541,
-0.032518383115530014,
-0.04251900687813759,
0.06098892167210579,
0.09588262438774109,
-0.06874459981918335,
-0.016035567969083786,
0.06333798170089722,
0.006549977231770754,
0.010070347227156162,
-0.017... |
Vitamin\tD\n2\n5-OH\n30-150\tng/mL\nBlood,\nsaliva\nVitamin\tD\tstatus\nBOX\t7.3\nCardiometabolic\tSpecific\tInflammatory\tMarkers\n•\t\nIncreased\tbody\tfat\t%,\tmost\toften\twith\televated\tBMI\tand\tVAT.\n•\t\nBMI\n•\t\nWaist\tCircumference\n•\t\nWaist/Height\n\tRatio\n•\t\nWaist/Hip\tRatio\n•\t\nBody\tfat\t%\t(bioele... | [
-0.028259219601750374,
-0.06429378688335419,
0.044478725641965866,
-0.03282950073480606,
-0.04741448536515236,
-0.05257587134838104,
0.05141419544816017,
0.09091222286224365,
-0.09174390882253647,
-0.0025957366451621056,
0.040928710252046585,
-0.04368337243795395,
0.02016819268465042,
-0.0... |
calipers)\n•\t\nBlood\tBiomarkers\tof\tprolonged\tinflammation\tin\tCVD/cardiometabolic\tsyndrome\twith\ndiabetes\n•\t\nHyperlipidemia/Hypertriglyceridemia\n•\t\nTotal\tCholesterol/HDL\tRatio\n•\t\nFasting\tGlucose/Fasting\tInsulin\n•\t\nHgbA1C\n•\t\nC-Reactive\tProtein-high\tsensitivity\t(CRP-hs\tor\tCRP-cardio)\n•\t\... | [
-0.0354883037507534,
-0.09795921295881271,
-0.03153706714510918,
0.013927465304732323,
-0.08729451149702072,
-0.03252473473548889,
0.015744373202323914,
0.10984674841165543,
0.020931681618094444,
-0.03354668989777565,
0.01026942115277052,
-0.012721040286123753,
0.042120687663555145,
0.0432... |
•\t\nHomocysteine\n•\t\nImaging:\tCoronary\tcalcium\tscan\n•\t\nMyeloperoxidase\t(blood)\n•\t\nOther\tassociations\tfor\tCVD/cardiometabolic\tsyndrome/diabetes:\n•\t\nSympathetic\tdominant\tmetabolism\t(metabolic\tstress)\n•\t\nStress\t(biochemical,\tglandular,\temotional,\tenvironmental,\tsmoking)\n•\t\nPoor\tsleep\n•... | [
-0.02109677344560623,
-0.084579236805439,
-0.02957097813487053,
0.018934259191155434,
-0.04789188504219055,
-0.003037596121430397,
0.03569209948182106,
0.10127248615026474,
-0.005380520597100258,
0.027299977838993073,
0.033282142132520676,
-0.020891057327389717,
0.021034501492977142,
0.035... |
•\t\nPoor\tsleep\n•\t\nApnea\nBOX\t7.4\nCancer-Specific\tInflammatory\tMarkers\n•\t\nVarious\tmetabolic\tmarkers\tmeasuring\tinflammatory\n\thallmarks\tof\tcancer\n•\t\nAdhesion:\tFibrinogen\tand\tplatelets\t(blood)\n•\t\nMetastasis\tpromoters:\n•\t\nCopper\t(Cu):\tZinc\tRatio\t1.0\tor\tless\t(rate\tlimiting\tto\tmetasta... | [
-0.03145420178771019,
-0.08955998718738556,
0.011202655732631683,
-0.018700208514928818,
-0.05438278988003731,
0.011553906835615635,
0.08014658838510513,
0.11040040105581284,
0.009104564785957336,
0.03495896980166435,
0.08990716934204102,
-0.025401674211025238,
0.02359410561621189,
0.06624... |
•\t\nCeruloplasmin\t(contributes\tto\tthe\ttotal\tCu\tload)\n•\t\nAngiogenesis\tpromoters\t(\nDai\tet\tal,\t2014\n):\tVEGF,\tadhesion\tfactors.\n•\t\nTumor-promoting\tinflammation:\tSpecific\ttype\tof\tcancer\tmarkers\t(examples:\tovarian\tcancer\nCA\t125,\tbreast\n\tcancer\tCA\t15-3,\tprostate\tcancer\tPSA).\tVarious\... | [
-0.07391542941331863,
-0.08338187634944916,
-0.009345721453428268,
-0.06264834851026535,
-0.04227446764707565,
0.024743327870965004,
0.10625682771205902,
0.08836161345243454,
0.020236128941178322,
0.02896551974117756,
0.10098420083522797,
-0.05604212358593941,
0.02061738446354866,
0.064480... |
and\tchemokines:\tTNF-α,\tIL-8,\tIL-6,\tetc.\n•\t\nGlycolysis\t(Warburg\tEffect:\tsugar\tis\tprimary\tfuel\tof\tcancer\tcells)\n•\t\nGrowth\tfactors\n•\t\nGenome\tinstability/mitochondrial\tDNA\n•\t\nLoss\tof\tapoptosis/cell\timmortality\nOther\tcommon\tphysiologic\tchanges\tshared\tby\tthese\tinflammatory\tconditions\... | [
-0.057186804711818695,
-0.08860417455434799,
-0.0355597659945488,
0.009605062194168568,
-0.06193865090608597,
0.018490564078092575,
0.025327427312731743,
0.036725182086229324,
0.020836692303419113,
0.06421999633312225,
0.0987752377986908,
-0.07677574455738068,
0.013961583375930786,
0.02616... |
nutrient\ttissue\n\tpools,\tplasma,\tand\tred\tblood\tcell\t(RBC)\tmembrane\tcomposition\tof\tpolyunsaturated\nfatty\tacids\tand\tantioxidants.\tThis\tmultifactorial\tsyndrome\t(referred\tto\tas\t\nmetabolic\tsyndrome\n)\tis\nrelated\tto\tobesity,\tand\tmore\timportantly,\tinsulin\tresistance\tand\t\nvisceral\tadipose\... | [
-0.019776195287704468,
-0.0760626271367073,
0.024881282821297646,
-0.016095180064439774,
-0.0837756022810936,
-0.003327709622681141,
0.08890122175216675,
0.05023116618394852,
-0.01074586994946003,
0.012439894489943981,
0.08420877903699875,
-0.0417400524020195,
0.012581552378833294,
0.03538... |
as\nevidenced\tby\tcentral\tadiposity.\t(See\t\nChapter\t29\n\tfor\tdiscussion\tof\tthe\tmetabolic\tsyndrome).\tHowever,\nthe\texpression\tof\tprolonged\n\tinflammation\tis\tindividual\tand\tdoesn’t\tnecessarily\tmanifest\tin\tall\tthe\ncharacteristics\tdescribed\tabove.\nFor\tthe\tnutritionist\tand\tdietitian\tto\tinc... | [
0.028633154928684235,
-0.038614071905612946,
0.05694034323096275,
0.003616528818383813,
-0.10723936557769775,
0.009838392026722431,
0.08790905028581619,
-0.016088061034679413,
-0.0017425997648388147,
0.06583479046821594,
0.11041116714477539,
-0.03464537858963013,
0.008160296827554703,
0.02... |
the\tnutrition\tassessment,\tit\tis\tuseful\tto\tconceptualize\tan\toverview\tof\ta\tperson’s\t\ntotal\tinflammatory\nload\n\t(\nFig.\t7.1\n).\tIt\tis\ta\tcompilation\tof\tevery\tfactor\tin\tthe\tpatient’s\thistory\tor\tstory\tthat\n\tcontributes\tto\nthe\tinflammation\tthat\ta\tperson\tcarries. | [
0.009356886148452759,
-0.022186074405908585,
0.05060237646102905,
-0.025429001078009605,
-0.10715644806623459,
0.037642352283000946,
0.08874119073152542,
-0.012880757451057434,
0.029412848874926567,
0.06885889172554016,
0.0770784318447113,
-0.026098918169736862,
-0.003484862856566906,
0.02... |
FIG.\t7.1\nTotal\tInflammatory\tLoad.\nAs\tvarious\tfactors\tare\tidentified\twithin\tdiet,\tlifestyle,\tenvironment,\tand\tgenetics,\tthe\tpattern\tof\nwhere\tthe\tmost\tinflammatory\trisk\tis\tbeing\tgenerated\tbecomes\tclear\tand\tgives\ta\tbasis\tof\thow\tto\nintervene\twith\ta\tplan\tfor\tmedical\tnutrition\tthera... | [
0.020863810554146767,
-0.021090513095259666,
0.09419792145490646,
-0.04459317401051521,
-0.03349689021706581,
0.021966973319649696,
0.07092427462339401,
0.012792583554983139,
-0.003112037433311343,
0.09687289595603943,
0.09402678161859512,
-0.07134191691875458,
0.038447774946689606,
0.0569... |
intervene\twith\ta\tplan\tfor\tmedical\tnutrition\ttherapy\t(MNT).\nAntigens\nAntigens\tare\ta\tsource\tof\tinflammation\tthat\tbecome\tamplified\twith\tchronic\texposure\t(see\t\nChapter\n25\n).\tDuring\tassessment\tof\tthe\ttotal\tinflammatory\tload\tof\tan\tindividual,\tthe\t“antigenic\tload”\tis | [
0.01157995406538248,
0.022295687347650528,
0.08632619678974152,
-0.062478769570589066,
-0.04573749750852585,
0.06492654979228973,
0.07890692353248596,
0.06722754240036011,
-0.05985463410615921,
0.07843687385320663,
0.10400622338056564,
-0.030382558703422546,
0.0032078793738037348,
0.093010... |
important.\tAntigens\tusually\tare\tthought\tto\tcome\tfrom\tfoods\tto\twhich\tone\tis\teither\tallergic\tor\nsensitive,\tbut\talso\tcan\tbe\tderived\tfrom\tcosmetics,\tclothing,\tinhalants,\tfurniture,\thousehold\tbuilding\nmaterials,\tand\tother\tsubstances\tin\tthe\tenvironment.\tAntigens\tfrom\tfood\tare\tmuch\tmor... | [
0.039072491228580475,
-0.020893491804599762,
0.07595757395029068,
-0.01178099773824215,
-0.06569240242242813,
0.028427274897694588,
0.09994986653327942,
-0.017101235687732697,
-0.03825640305876732,
0.07813713699579239,
0.08541901409626007,
-0.05856003984808922,
0.01203224342316389,
-0.0146... |
significant\n\twhen\ta\tperson\thas\tlost\tgut\tbarrier\tintegrity\tand\ta\tsituation\tof\tintestinal\tpermeability,\nsometimes\treferred\tto\tas\t“leaky\tgut”\texists\t(\nFasano,\t2012\n).\tThis\tcondition\tprovides\taccess\tfor\tlarger\nmolecules\tto\tenter\tthe\tinternal\tmicroenvironment,\tsetting\toff\ta\tcascade\... | [
0.07198154926300049,
-0.022267350926995277,
0.08558229357004166,
-0.0044919769279658794,
-0.01748574525117874,
0.007123623043298721,
0.058734066784381866,
0.039514441043138504,
-0.017563439905643463,
0.09214965254068375,
0.10315370559692383,
-0.078148253262043,
-0.03728943690657616,
0.0275... |
(see\t\nChapters\t25\n\tand\t\n27\n).\nGenomics\nPredictive\tgenomic\ttesting,\tfamily\thistory,\tand\tpersonal\thistory\tare\n\tgathered\tas\tthe\tpractitioner\nhears\tthe\tpatient’s\tstory\tduring\tan\tassessment.\tThis\tinformation\thelps\tpaint\ta\tpicture\tof\nbiochemical\tindividuality\n,\tthat\teach\tperson\thas... | [
0.028621241450309753,
0.006325565744191408,
0.07004554569721222,
0.013966778293251991,
-0.07789032906293869,
0.02606685273349285,
0.06363408267498016,
0.0023607625626027584,
-0.0053846100345253944,
0.07502514868974686,
0.08721692860126495,
-0.05353767052292824,
-0.040917400270700455,
0.039... |
,\tthat\teach\tperson\thas\tgenetic\tand\tchemical\tuniqueness,\twhich\ninfluences\tthe\tresponse\tto\tinflammation.\tSince\tthe\tcompletion\tof\tthe\tHuman\tGenome\tProject\t(2003),\nthe\trapid\tdevelopment\tof\tgenomic\ttesting\tfor\tclinical\tapplication\thas\tgreatly\tenhanced\tthe\ttoolbox\n\tof | [
-0.012579541653394699,
-0.014439158141613007,
0.048018526285886765,
-0.021041087806224823,
-0.07430929690599442,
0.021235164254903793,
0.00274606142193079,
-0.014960113912820816,
0.01088964194059372,
0.09255349636077881,
0.08490348607301712,
-0.04655555635690689,
-0.01452978141605854,
-0.0... |
of\nthe\tnutrition\tpractitioner.\tNutrigenomics,\tnutrigenetics,\tand\tepigenetics\tare\tnew\tfields\tof\tstudy\nabout\tthe\tway\tthe\tindividual\tmetabolically\tinteracts\twith\ttheir\tenvironment\t(\nDick,\t2015\n;\tsee\t\nChapter\n6\n).\nBody\tcomposition\nChronic\tdiseases\tare\trelated\tdirectly\tto\t\nincreased\... | [
-0.014582186937332153,
-0.030613012611865997,
0.049518000334501266,
-0.060845695436000824,
-0.061324089765548706,
0.0043007140047848225,
0.03454812616109848,
0.013228575699031353,
-0.010407410562038422,
0.06294971704483032,
0.061677005141973495,
-0.0453624427318573,
0.020518625155091286,
0... |
increased\tbody\tfat\texacerbated\tby\tphysical\tinactivity,\tpoor\ndiet,\t\nlack\tof\trestorative\tsleep,\tand\timmune\tstress,\tall\tof\twhich\n\tdrive\t\nincreased\tinflammation.\tOf\nequal\timportance\twith\tincreased\tbody\t\nfat\tpercentage\tis\tthe\tfat\tdistribution.\tCentral\tadiposity\tat\tall | [
0.036913082003593445,
-0.09658138453960419,
0.08899465203285217,
0.007914041168987751,
-0.06408767402172089,
0.013520204462110996,
0.08429516106843948,
0.0163672287017107,
-0.011185591109097004,
0.039698194712400436,
0.06424637883901596,
-0.045946817845106125,
0.016211867332458496,
0.03404... |
fat\tpercentage\tis\tthe\tfat\tdistribution.\tCentral\tadiposity\tat\tall\nages\tis\tthe\tmost\tserious\thealth\tconcern.\tVAT\thas\tbeen\tdiscovered\tto\thave\tendocrine\tfunctions\twith\nthe\tsecretion\tof\tseveral\tknown\tinflammatory\tadipokines,\tsuch\tas\tresistin,\tleptin,\tand\tadiponectin,\nand\tTNF-α—all\tcon... | [
-0.027090638875961304,
-0.10529378056526184,
0.04177163168787956,
-0.016351526603102684,
-0.05960271880030632,
-0.01806103251874447,
0.0794130265712738,
0.06960602104663849,
0.0024859034456312656,
0.04566581919789314,
0.09966980665922165,
-0.04374368116259575,
0.01260896772146225,
0.038144... |
and\tTNF-α—all\tcontributing\tto\tthe\tsystemic\ttotal\tinflammatory\n\tload\t(\nHughes-Austin\tet\tal,\t2014\n).\nSarcopenia\n\tresults\tfrom\ta\twasting\tof\tlean\tbody\tmass\tand\tmuscle\tstrength\tfrom\tthe\tongoing\ninflammatory\tburden\tand\tis\texacerbated\tby\tdecreased\tphysical\tactivity\t(\nda\tSilva\tet\tal... | [
0.03730335831642151,
-0.12532931566238403,
0.033279918134212494,
0.018114062026143074,
-0.09111258387565613,
0.01429725345224142,
0.07069601863622665,
0.024135494604706764,
0.012056758627295494,
0.06278250366449356,
0.07782872766256332,
-0.03864100202918053,
0.011462138034403324,
0.0791851... |
da\tSilva\tet\tal,\t2019\n).\nSarcopenic\tobesity\n\tis\taccompanied\tby\tincreased\tbody\tfat\tpercentage,\tespecially\tthe\tdeposit\tof\tVAT\nwith\tincreasing\twaist\tcircumference,\tbut\tfor\tsome\tindividuals\tthe\tloss\tof\tmuscle\n\tand\tincreased\tfat\nmass\tpercentage\tcan\texist\tfor\tany\tbody\tmass\tindex\t(... | [
-0.023101067170500755,
-0.05436064675450325,
0.042132265865802765,
0.04124470800161362,
-0.08998705446720123,
-0.021236544474959373,
0.10196978598833084,
0.01560714840888977,
-0.06935644149780273,
-0.002242558402940631,
0.09346877038478851,
-0.07341569662094116,
0.009591998532414436,
0.012... |
overweight\tand\tobesity.\tThis\tunderscores\tthe\timportance\tof\tassessing\tmore\tdetail\tthan\tonly\tBMI\n(\nGonzalez\tet\tal,\t2017\n;\t\nNorman\tand\tMatthews,\t2008\n).\tThe\tBMI\talone\tdoes\tnot\tadequately\ncharacterize\tthe\tdistribution\tof\tadipose\ttissue\tand\trecommendations\texist\tfor\tmore\tspecific\n... | [
-0.023444006219506264,
-0.032863494008779526,
0.0647149458527565,
0.008923538960516453,
-0.06149179860949516,
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0.09996778517961502,
-0.025856835767626762,
-0.03500206768512726,
0.03859454393386841,
0.07308007031679153,
-0.0614173598587513,
0.028246236965060234,
-0.0083... |
measures\twith\n\tbetter\tpredictive\tvalue\t(\nGonzalez\tet\tal,\t2017\n).\tThe\tnutritionist’s\ttools\tfor\tassessing\nsarcopenia\tvary\tfrom\tusing\tthe\twaist-to-hip\tratio,\twaist-to-height\tratio,\tbioelectric\timpedance\nanalysis\t(BIA),\thandgrip\tstrength\t(dynamometer),\tor\tdual-energy\tx-ray\tabsorptiometry... | [
-0.019662393257021904,
-0.002277151681482792,
0.029799552634358406,
0.010181877762079239,
-0.0720735490322113,
-0.03410392254590988,
0.04523978754878044,
0.03525925055146217,
0.04881642758846283,
0.024856025353074074,
0.09559033066034317,
-0.06256387382745743,
0.062294505536556244,
0.04378... |
available\t(\nSpringstroh\tet\tal,\t2016\n)\t(see\t\nChapter\t5\n\tand\t\nClinical\tInsight\n:\tSarcopenic\tObesity\n).\nCLINICAL\tINSIGHT\nSarcopenic\tObesity | [
-0.015066935680806637,
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0.0007476107566617429,
-0.02372741512954235,
0.061318885535001755,
0.07746592164039612,
0.04569205641746521,
0.016789207234978676,
0.03928641602396965,
0.06800857186317444,
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0.0... |
In\tthis\tfigure,\tbody\tcomposition\tis\tdepicted\tby\ta\tspectrum\tof\tASMI\tand\tFMI\t(low\tto\thigh).\tOn\tthe\nbasis\tof\tthe\tBaumgartner\tmodel\t(Waters\tand\tBaumgartner,\t2011),\tthese\tphenotypes\tcan\tbe\ndepicted\tas\tfollows:\nLA-HM\t=\tlow\tadiposity\twith\thigh\tmuscle\tmass\t(individuals\twith\tlow\tFMI... | [
0.04051997885107994,
-0.0258176289498806,
0.07649125158786774,
-0.013056480325758457,
-0.08287947624921799,
-0.027707071974873543,
0.060219552367925644,
-0.024306559935212135,
0.017229409888386726,
0.028669917955994606,
0.08859063684940338,
-0.05628011003136635,
0.0454879067838192,
0.01264... |
HA-HM\t=\thigh\tadiposity\twith\thigh\tmuscle\tmass\t(individuals\twith\thigh\tFMI\tand\tASMI)\nLA-LM\t=\tlow\tadiposity\n\twith\tlow\tmuscle\tmass\t(individuals\twith\tlow\tASMI\tand\tFMI)\nHA-\tLM\t=\thigh\tadiposity\twith\tlow\tmuscle\tmass\t(individuals\twith\thigh\tFMI\tand\tlow\tASMI).\nThose\twith\t\nLA-HM\twoul... | [
0.031812481582164764,
0.04649443179368973,
0.06595657020807266,
-0.027914095669984818,
-0.07519908994436264,
-0.04751821979880333,
0.11038697510957718,
-0.03890020400285721,
-0.0396714024245739,
0.05420592054724693,
0.1257745772600174,
-0.06900230050086975,
0.0542164072394371,
-0.021557332... |
Those\twith\t\nLA-HM\twould\tbe\tthe\tleast\thealthy.\nCutoffs\twere\tdefined\taccording\tto\tthe\tfollowing\tdeciles:\nLA-HM\t(ASMI:\t50-100;\tFMI:\t0-49.99)\nHA-HM\t(ASMI:\t50-100;\tFMI:\t50-100)\nLA-LM\t(ASMI:\t0-49.99;\tFMI:\t0-49.99)\nHA-LM\t(ASMI:\t0-49.99;\tFMI:\t50-100).\nASMI\n,\tAppendicular\tskeletal\t\nmusc... | [
-0.07278111577033997,
-0.010580861009657383,
0.014421050436794758,
-0.027009963989257812,
-0.10312019288539886,
-0.110012948513031,
0.07256190478801727,
0.03227602317929268,
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-0.018093695864081383,
0.12376761436462402,
-0.07990743219852448,
0.029007604345679283,
0.0551... |
,\tAppendicular\tskeletal\t\nmuscle\tmass\tindex;\t\nFMI\n,\tfat\tmass\tindex.\nCarla\tMM\tPrado\tet\tal:\tA\tpopulation-based\tapproach\tto\tdefine\tbody-composition\tphenotypes,\t\nAm\tJ\tClin\nNutr\n,\t99:1369,\t2014.\nBody\tcomposition\tcan\tbe\tassessed,\tand\tif\tfound\tto\tbe\tabnormal\tbased\tan\tindividual’s\t... | [
0.0049183424562215805,
-0.035771694034338,
0.07729978859424591,
-0.04625603184103966,
-0.11480336636304855,
-0.014423295855522156,
0.0992119312286377,
0.00028261865372769535,
-0.029770977795124054,
0.027109164744615555,
0.12304000556468964,
-0.04178496450185776,
-0.004385356791317463,
0.01... |
mass\t(LBM)\tand\tfat\tmass\t(FM),\tit\tshould\tbe\tconsidered\ta\tprimary\tmarker\tfor\tmonitoring\tprolonged\ninflammation\n\t(\nBiolo\tet\tal,\t2015\n;\t\nJuby,\t2014\n).\nAccording\tto\t\nKhan,\tS\tet\tal,\t(2014):\nObesity\ttoday\tstands\tat\tthe\tintersection\tbetween\tinflammation\tand\tmetabolic\tdisorders\tcau... | [
-0.054093342274427414,
-0.0014110207557678223,
0.07645825296640396,
0.00998918991535902,
-0.04931925982236862,
-0.0014949665637686849,
0.04102366417646408,
0.0368366464972496,
0.015112734399735928,
-0.0039052143692970276,
0.07897190004587173,
-0.04660814255475998,
-0.0012404199223965406,
0... |
aberration\tof\timmune\tactivity,\tand\tresulting\tin\tincreased\trisk\tfor\tdiabetes,\tatherosclerosis,\tfatty\tliver,\nand\tpulmonary\tinflammation\tto\tname\ta\tfew.\nEnergy\tdysregulation\nAnother\tunderlying\tphysiologic\tsystem\tinvolved\tin\n\tinflammation\tis\tcompromised\tmitochondrial\nproduction\tof\tadenosi... | [
-0.01558111235499382,
-0.07434885203838348,
0.058770108968019485,
-0.009489553980529308,
-0.11305973678827286,
-0.012696132995188236,
0.08065399527549744,
0.043658237904310226,
-0.006055596750229597,
0.0756235122680664,
0.07791866362094879,
-0.04826272279024124,
0.01202361285686493,
0.0739... |
Cherry\tand\tPiantadosi,\t2015\n).\tAssessment\tof\nmitochondrial\tfunction\tfocuses\ton\tstructure\tand\tfunction\tby\tconsidering\tconutrients\tsuch\tas\ncoenzyme\tQ\n10\n,\tand\talpha-\nlipoic\tacid\n\tand\tgamma(γ)-linolenic\tacid\t(GLA)\t(already\tproduced\tby\tthe\nbody),\tand\ttheir\tprotective\teffects\tagainst... | [
-0.02322244457900524,
-0.08845894038677216,
0.06143801286816597,
-0.00015751604223623872,
-0.08175064623355865,
0.030073104426264763,
0.11863081902265549,
0.06129841133952141,
-0.030273832380771637,
0.04490923881530762,
0.1400156319141388,
-0.06520996987819672,
-0.005755298770964146,
0.009... |
Quelling\tsystemic\nprolonged\tinflammation\tpromotes\ta\thealthier\tmicroenvironment\tfor\timproved\tmitochondrial\tfunction\nand\tenergy\tproduction.\nMitochondrial\tdisease\tor\tdysfunction\tis\tan\tenergy\tproduction\tproblem.\tAlmost\tall\tcells\tin\tthe\tbody\nhave\tmitochondria\tthat\tproduce\ta\tbody’s\tessenti... | [
0.02866402082145214,
-0.056800726801157,
0.08369463682174683,
-0.0015022975858300924,
-0.05337386205792427,
0.026270337402820587,
0.09893770515918732,
0.06779302656650543,
-0.03125122934579849,
0.0904616042971611,
0.08822561055421829,
-0.05932990461587906,
0.06285732239484787,
0.0289704035... |
cellular\tfunction\tand\treduce\tmitochondrial\tenergy\toutput.\tWhen\tthat\n\thappens,\tsome\tbody\tsystems\nmay\tbe\timpaired\tcausing\tmuscle\tweakness,\torgan\tdysfunction,\thormone\timbalance,\tdisrupted\ncognition,\tand\tlowered\timmunity\t(\nMiller\tet\tal,\t2018\n).\tThe\tcomplaint\tof\tfatigue\tis\tthe\tmost\t... | [
-0.023489663377404213,
-0.05222724378108978,
0.0652669221162796,
-0.05187489092350006,
-0.11973512172698975,
-0.013578124344348907,
0.0843355655670166,
0.06485018134117126,
0.03224082663655281,
0.07783130556344986,
0.09558253735303879,
-0.025389989838004112,
0.05304451286792755,
0.03493924... |
phenotypic\texpression\tof\tmitochondrial\tdysfunction\t(see\t\nClinical\tinsight\n:\tInflammaging\n).\nCLINICAL\tINSIGHT\nInflammaging | [
0.015677418559789658,
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0.023121561855077744,
0.019465504214167595,
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0.021709943190217018,
0.10262556374073029,
0.038712695240974426,
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0.07935306429862976,
0.10551044344902039,
-0.0841464251279831,
-0.0301751047372818,
0.05250... |
Aging\tis\ta\tubiquitous\tcomplex\t\nphenomenon\tthat\tresults\tfrom\n\tenvironmental,\tgenetic,\tand\nepigenetic\tevents\tin\tdifferent\tcell\ttypes\tand\ttissues\tand\ttheir\tinteractions\tthroughout\tlife.\tA\npervasive\tfeature\tof\taging\ttissues\tand\tmost,\tif\tnot\tall,\tage-related\tdiseases\tis\tchronic | [
0.0367012619972229,
0.0014783093938603997,
0.1017870306968689,
0.028432736173272133,
-0.05308609828352928,
0.010980166494846344,
0.06954405456781387,
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0.09144150465726852,
0.10509120672941208,
-0.08868417888879776,
-0.01249144971370697,
0.00075377... |
inflammation.\t“Inflammaging”\tdescribes\tthe\tlow-grade,\tchronic,\tsystemic\tinflammation\tin\taging,\nin\tthe\tabsence\tof\tovert\tinfection\t(“sterile”\tinflammation)\tand\tis\ta\thighly\tsignificant\n\trisk\tfactor\tfor\nmorbidity\tand\tmortality\tin\tthe\telderly\t(\nFranceschi\tand\tCampisi,\t2014\n). | [
-0.01044660247862339,
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0.01157659012824297,
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0.1238003596663475,
0.11341309547424316,
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0.10339590162038803,
0.04521271586418152,
-0.024241002276539803,
-0.012245181947946548,
0.096... |
Franceschi\tand\tCampisi,\t2014\n).\nThe\tratios\tof\tcarbohydrate,\tfat,\tand\tprotein\tinfluence\tmitochondrial\tfunction,\tprimarily\taffecting\nglucose-insulin\tregulation.\tDuring\teach\tassessment,\tdetermination\tof\tthe\tmost\tfavorable\nmacronutrient\tratios\tand\tindividual\tnutrient\trequirements\tprovides\t... | [
0.030842293053865433,
-0.06222504377365112,
0.03599465265870094,
0.01567927934229374,
-0.0784013643860817,
0.025220444425940514,
0.11771049350500107,
0.026034919545054436,
0.019836638122797012,
0.04765879735350609,
0.10022412985563278,
-0.04238399490714073,
-0.008388852700591087,
0.0058793... |
effective\tinterventions\n\tfor\trestoring\tmitochondrial\thealth\tand\tgeneral\twellness.\tThere\tis\tan\nincreasing\tpopularity\tand\tevidence\tbase\tfor\tlow-carbohydrate,\tpaleo,\tand\tketogenic\tdiets\tfor\nmitochondrial\tsupport\tfor\tsome\tconditions,\tsuch\tas\tepilepsy,\tneurodegenerative\tdiseases,\tand\nonco... | [
0.049674585461616516,
-0.024416547268629074,
0.06884230673313141,
0.010956375859677792,
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0.012706219218671322,
0.09520673006772995,
0.04731655865907669,
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0.055588435381650925,
0.08891662210226059,
0.025491813197731972,
-0.0011608462082222104,
0.0... |
oncology\t(\nAllen\tet\tal,\t2014\n).\tIt\tis\tworth\tnoting\tthat\tthe\tnutritional\tassessment\tof\tan\tindividual\tshould\ninclude\ta\tdiet\thistory\tto\tevaluate\tthe\n\tmacronutrients\tconsumed.\tBecause\tof\tthe\tcommon\ttendency\nfor\ta\thigh\tprotein\tintake\tas\tpart\tof\ta\tlow-carbohydrate\tdiet,\tthe\texces... | [
0.02066347934305668,
-0.03997138515114784,
0.023394383490085602,
0.0018840202828869224,
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0.013624065555632114,
0.0685822144150734,
0.06251302361488342,
0.022219998762011528,
0.03476112335920334,
0.0677136555314064,
0.03286562114953995,
0.016642272472381592,
0.00289176590... |
increase\tgluconeogenesis,\tthus\tthwarting\tthe\tbenefit\tof\tlow\tcarb\tby\tincreasing\tavailable\tmetabolic\nglucose.\tThe\tprinciple\tof\tthe\tketogenic\tdiet\t(KD)\treplaces\tall\tbut\tlow\tand\tnonstarchy\tvegetable\ncarbohydrates\t(20\tto\t100\tg\tcholesterol\t[CHO])\twith\n\tlow\tto\tmoderate\tamounts\tof\tprot... | [
-0.05491790920495987,
-0.07732333987951279,
-0.008565090596675873,
0.00870189443230629,
-0.12480754405260086,
-0.008024576120078564,
0.02594958245754242,
0.11817909777164459,
-0.01993440091609955,
-0.009072276763617992,
0.08180695027112961,
0.003881324315443635,
0.0018847647588700056,
-0.0... |
low\tto\tmoderate\tamounts\tof\tproteins\t(0.8\tto\t1.0\ng\tprotein/kg\tideal\tbody\tweight)\tand\thigh\tamounts\tof\tshort-chain,\tmedium\tchain\tand\nmonounsaturated,\tand\tpolyunsaturated\tfats,\tpreferably\tfrom\twhole\tand\tunprocessed\tfoods\t(\nMiller\tet\nal,\t2018\n;\tsee\t\nAppendix\t19\n).\nMicrobiome | [
-0.01045142114162445,
-0.054543688893318176,
0.04030422121286392,
0.03319014608860016,
-0.05045638605952263,
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0.06396061927080154,
0.09195034205913544,
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-0.012702200561761856,
0.11083139479160309,
-0.06991320848464966,
0.016055544838309288,
-0.0035... |
Miller\tet\nal,\t2018\n;\tsee\t\nAppendix\t19\n).\nMicrobiome\nAfter\tthe\tHuman\tGenome\tProject,\tthe\tNational\tInstitutes\tof\tHealth\t(NIH)\tlaunched\tstudies\tfor\ngenomic\tidentification\tand\tcharacterization\n\tof\tthe\tmicroorganisms\tassociated\twith\thealthy\tand\ndiseased\thumans.\tThe\texciting\tfindings\... | [
-0.014095107093453407,
-0.054145414382219315,
-0.010090515948832035,
-0.036364536732435226,
-0.0830615758895874,
0.04109768941998482,
0.054386287927627563,
0.0047768219374120235,
0.015985505655407906,
0.05010941997170448,
0.10170529037714005,
-0.04033424332737923,
-0.01761302538216114,
0.0... |
the\tgastrointestinal\t[GI]\ttract).\tThe\ttotal\tnumber\tof\tgenes\tin\tthe\thuman\tmicrobiome\tis\t10\ttimes\ngreater\tthan\tthe\thuman\tgenome.\tWhen\tthe\tdelicate\tmicrobiome\tcommunity\tin\tand\ton\tthe\tbody\tis\ndisturbed\tand\taltered\tfrom\thealthy\tbaseline,\n\tit\tbecomes\ta\tfactor\tin\tpromoting\tprolonge... | [
-0.011212418787181377,
-0.03776869177818298,
0.03689130023121834,
-0.008673937059938908,
-0.10424058884382248,
0.010793186724185944,
0.05976836755871773,
0.02510983869433403,
-0.008232004940509796,
0.069505974650383,
0.14366310834884644,
-0.06509134918451309,
-0.019570739939808846,
0.04942... |
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