Hugging Face's logo

Datasets:
Nason
/
clinicaltrials-database

Tasks:
Tabular Classification
Tabular Regression
Size:
10M<n<100M
Tags:
clinical-trials
clinicaltrials-gov
aact
duckdb
medical
health
License:
Dataset card Files
xet
 Community
clinicaltrials-database / README.md
Nason's picture
Nason
Upload README.md with huggingface_hub
6a09837 verified
preview code
|
raw
history blame contribute delete
5.97 kB
metadata 
license: cc0-1.0
task_categories:
  - tabular-classification
  - tabular-regression
tags:
  - clinical-trials
  - clinicaltrials-gov
  - aact
  - duckdb
  - medical
  - health
  - government-data
pretty_name: ClinicalTrials.gov Database
size_categories:
  - 10M<n<100M

ClinicalTrials.gov Database (AACT)

A clean, queryable DuckDB database built from the AACT flat files -- the most comprehensive structured export of ClinicalTrials.gov data.

56,397,018 rows across 48 tables covering every registered clinical trial.

Built with clinicaltrials-database.

Quick Start

DuckDB CLI 

INSTALL httpfs;
LOAD httpfs;
ATTACH 'https://huggingface.co/datasets/Nason/clinicaltrials-database/resolve/main/clinicaltrials.duckdb' AS ct (READ_ONLY);

-- Trials by phase
SELECT overall_status, COUNT(*) as n
FROM ct.studies
GROUP BY overall_status
ORDER BY n DESC;

Python 

import duckdb
con = duckdb.connect()
con.sql("INSTALL httpfs; LOAD httpfs;")
con.sql("""
    ATTACH 'https://huggingface.co/datasets/Nason/clinicaltrials-database/resolve/main/clinicaltrials.duckdb'
    AS ct (READ_ONLY)
""")
con.sql("SELECT * FROM ct.studies LIMIT 5").show()

DuckDB uses HTTP range requests, so only the pages needed for your query are downloaded.

Tables

Table Description Rows
reported_events Summary of reported adverse events 11,446,277
outcome_measurements Summary data for outcome measures by study group 4,777,352
browse_conditions NLM-generated MeSH terms for study conditions 4,194,046
design_outcomes Planned outcome measures and observations 3,566,612
facilities Facility names, addresses, and recruiting status 3,410,973
baseline_measurements Demographic and baseline measures by group 2,808,533
browse_interventions NLM-generated MeSH terms for study interventions 2,480,003
result_groups Aggregate list of group titles/descriptions for results reporting 2,120,694
outcome_counts Sample sizes for each outcome by study group 1,537,817
keywords Investigator-provided keywords describing the study 1,523,516
design_group_interventions Cross-reference mapping design groups to interventions 1,283,125
study_references Citations to publications related to the study 1,078,399
design_groups Protocol-specified groups or cohorts assigned to interventions 1,056,031
conditions Disease or condition names studied in each trial 1,025,650
interventions Interventions or exposures: drugs, devices, procedures, vaccines 973,952
sponsors Sponsor and collaborator names and types 920,618
milestones Participant progress through each stage of the study 855,865
countries Countries where the study has sites 783,722
id_information Identifiers other than NCT ID (org study IDs, secondary IDs) 748,312
outcomes Outcome measure descriptions and time frames 638,016
outcome_analysis_groups Groups involved in each outcome analysis 609,509
drop_withdrawals Summary of participant withdrawals: counts and reasons 577,923
reported_event_totals Totals of reported adverse events by category 577,536
calculated_values AACT-computed fields: months to report results, facilities count, etc. 576,029
studies Core study record: title, status, phase, type, dates, enrollment, and regulatory info 576,029
brief_summaries Brief text summary of the study protocol 575,064
detailed_descriptions Detailed text description of the study protocol 575,064
eligibilities Participant eligibility criteria (inclusion/exclusion, age, sex) 575,064
designs Study design details: allocation, masking, assignment, purpose 571,286
responsible_parties Parties responsible for submitting study information 557,553
overall_officials People responsible for overall scientific leadership 519,601
search_term_results 494,618
intervention_other_names Synonymous names for interventions 470,456
facility_contacts Contact information at each study facility 409,886
outcome_analyses Statistical analyses performed on outcomes 315,026
baseline_counts Sample sizes at baseline for each study group 230,199
facility_investigators Investigator names at each study facility 223,509
central_contacts Primary and backup contacts for enrollment questions 217,960
ipd_information_types Individual participant data sharing information types 87,849
provided_documents Protocol, SAP, and informed consent form documents 78,018
result_contacts Points of contact for scientific information about results 76,963
result_agreements Agreements between sponsor and principal investigators about results 76,963
participant_flows Recruitment and pre-assignment details 76,963
links Web links relevant to the study 74,921
pending_results Events related to submission of results for QC review 32,304
documents Full study protocol and statistical analysis plan 10,692
retractions Retraction notices for study results or publications 334
search_terms 186

Data Source

AACT (Aggregate Analysis of ClinicalTrials.gov) -- maintained by the Clinical Trials Transformation Initiative (CTTI). Updated daily from ClinicalTrials.gov. This is public domain U.S. government data.

License

Database build code: MIT. Underlying data: public domain (U.S. government work).

GitHub

Full source code, build instructions, and data dictionary: github.com/ian-nason/clinicaltrials-database