PMCID
string
Title
string
Sentences
string
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
OE: OverExpression.
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
shRNA: short hairpin RNA.
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
NC: negative control.
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
OD, Optical Density.
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
circ_SMA4: circ_103870.
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
CircRNAs are known to function as miRNA sponges, regulating the expression of specific target genes.
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
In our study, we identified hsa-miR-494-3p, hsa-miR-1271-5p, hsa-miR-96-5p, hsa-miR-410-5p, and hsa-miR-661 as the top five targeted miRNAs for circ_SMA4 (Fig. 3A).
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
A schematic representation of the potential binding sites between op five targeted miRNAs and the circ_SMA4-3’-UTR is presented in Fig. 3B.
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
Among them, notably, hsa-miR-494-3p exhibited the highest binding score (Context score) with circ_SMA4, prompting the selection of miR-494-3p for further exploration in our study.
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
Fig. 3circ_SMA4 serves as an Efficient miRNA Sponge for miR-494-3p in GISTs. (
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
The top five targeted miRNAs by circ_SMA4. (
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
A schematic representation of the potential binding sites between op five targeted miRNAs and the circ_SMA4-3’-UTR. (
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
C-D) RT-qPCR analysis demonstrating the downregulation of miR-494-3p in GIST-T1 and GIST-882 cells lines and tissues, compared to HGSMC cells and adjacent tissues. (
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
Pearson’s correlation analysis showing a negative correlation between circ_SMA4 and miR-494-3p expression in GISTs tissues.
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
n = 20. (
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
Dual-luciferase reporter assay confirmed that miR-494-3p could competitively targeted circ_SMA4 (HEK-293T). (
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
RT-qPCR assay demonstrated that miR-494-3p expression was significantly and negatively regulated by circ_SMA4 expression in GISTs cells.
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
n = 3. *
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
P < 0.05, **P < 0.01, na: no statistical significance.
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
RT-qPCR, reverse transcription- quantitative PCR.
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
OE: OverExpression.
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
shRNA: short hairpin RNA.
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
NC: negative control.
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
OD, Optical Density.
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
circ_SMA4: circ_103870.
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
circ_SMA4 serves as an Efficient miRNA Sponge for miR-494-3p in GISTs. (
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
The top five targeted miRNAs by circ_SMA4. (
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
A schematic representation of the potential binding sites between op five targeted miRNAs and the circ_SMA4-3’-UTR. (
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
C-D) RT-qPCR analysis demonstrating the downregulation of miR-494-3p in GIST-T1 and GIST-882 cells lines and tissues, compared to HGSMC cells and adjacent tissues. (
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
Pearson’s correlation analysis showing a negative correlation between circ_SMA4 and miR-494-3p expression in GISTs tissues.
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
n = 20. (
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
Dual-luciferase reporter assay confirmed that miR-494-3p could competitively targeted circ_SMA4 (HEK-293T). (
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
RT-qPCR assay demonstrated that miR-494-3p expression was significantly and negatively regulated by circ_SMA4 expression in GISTs cells.
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
n = 3. *
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
P < 0.05, **P < 0.01, na: no statistical significance.
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
RT-qPCR, reverse transcription- quantitative PCR.
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
OE: OverExpression.
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
shRNA: short hairpin RNA.
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
NC: negative control.
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
OD, Optical Density.
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
circ_SMA4: circ_103870.
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
Subsequent assays, RT-qPCR assay demonstrated that miR-494-3p was significantly downregulated in GIST-T1 and GIST-882 cells (P < 0.05; Fig. 3C) and GISTs tissues (n = 20; P < 0.05; Fig. 3D), compared to HGSMC cells and adjacent tissues.
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
Pearson’s correlation analysis highlighted a negative correlation between circ_SMA4 and miR-494-3p expression in GISTs tissues (n = 20; r=-0.55, P = 0.01; Fig. 3E).
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
Additionally, a dual-luciferase reporter assay was performed to verify the respective binding sites (MRE)-based circ_SMA4-miR-494-3p interaction.
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
The results demonstrated a significant reduction in luciferase activity in HEK-293T cells co-transfected with pmirGLO-circ_SMA4-wt and miR-494-3p mimic compared to cells co-transfected with pmirGLO-circ_SMA4-wt and miR-494-3p NC (P < 0.05; Fig. 3F).
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
However, no significant change in luciferase activity was observed in cells co-transfected with pmirGLO-circ_SMA4-mut and miR-494-3p mimic or pmirGLO-circ_SMA4-mut and miR-494-3p NC (P > 0.05; Fig. 3F).
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
Moreover, miR-494-3p expression was found to be significantly and negatively regulated by circ_SMA4 expression in GIST-T1 and GIST-882 cells (P < 0.05; Fig. 3G).
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
Furthermore, in order to investigate the impact of miR-494-3p on GISTs, we successfully constructed miR-494-3p mimic and inhibitor and subsequently stably transfected them into GIST-T1 and GIST-882 cells using Lipofectamine (P < 0.05; Fig. 4A).
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
The ensuing CCK-8 assay revealed that miR-494-3p overexpression significantly inhibited the proliferation of GISTs cells, while miR-494-3p knockdown markedly promoted GISTs cell proliferation (P < 0.05; Fig. 4B).
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
The Annexin V-FITC/PI assay demonstrated that miR-494-3p overexpression significantly promoted GISTs cell apoptosis, whereas miR-494-3p knockdown significantly suppressed GISTs cell apoptosis (P < 0.05; Fig. 4C).
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
The cumulative evidence indicates that miR-494-3p serves as one of the functional target miRNAs of circ_SMA4, manifesting a miRNA sponge effect.
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
Moreover, miR-494-3p assumes the role of a tumor suppressor in GISTs.
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
Fig. 4miR-494-3p plays a tumor suppressor role in GISTs. (
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
Successful establishment of miR-494-3p overexpression and knockdown cellular models: miR-494-3p mimic and inhibitor and subsequently stably transfected them into GIST-T1 and GIST-882 cells, respectively.
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
The transfection efficiency was assessed by RT-qPCR. (
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
Cell counting kit-8 (CCK8) assay and (C) Annexin V-FITC/PI assay was performed to analyze the effect of miR-494-3p on GISTs cell proliferation and apoptosis.
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
n = 3. *
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
P < 0.05, **P < 0.01.
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
RT-qPCR, reverse transcription- quantitative PCR.
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
OE: OverExpression.
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
shRNA: short hairpin RNA.
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
NC: negative control.
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
OD, Optical Density.
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
circ_SMA4: circ_103870.
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
miR-494-3p plays a tumor suppressor role in GISTs. (
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
Successful establishment of miR-494-3p overexpression and knockdown cellular models: miR-494-3p mimic and inhibitor and subsequently stably transfected them into GIST-T1 and GIST-882 cells, respectively.
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
The transfection efficiency was assessed by RT-qPCR. (
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
Cell counting kit-8 (CCK8) assay and (C) Annexin V-FITC/PI assay was performed to analyze the effect of miR-494-3p on GISTs cell proliferation and apoptosis.
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
n = 3. *
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
P < 0.05, **P < 0.01.
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
RT-qPCR, reverse transcription- quantitative PCR.
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
OE: OverExpression.
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
shRNA: short hairpin RNA.
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
NC: negative control.
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
OD, Optical Density.
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
circ_SMA4: circ_103870.
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
The potential targets of miR-494-3p were predicted through three miRNA target gene databases (miRBase, TargetScan, and miRanda), KIT, a well-known proto-oncogene, is simultaneously predicted by three miRNA databases (as shown in Fig. 5A).
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
Based on microRNA Response Element (MRE) analysis, miR-494-3p was found to have potential binding sites within the 3’-UTR region of KIT (as shown in Fig. 5B).
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
Fig. 5KIT identified as a functional target gene for miR-494-3p in GISTs. (
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
KIT was simultaneously predicted by three miRNA databases (miRBase, TargetScan, and miRanda). (
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
Schematic representation of potential binding sites between miR-494-3p and KIT. (
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
C-D) RT-qPCR analysis demonstrating the upregulation of KIT mRNA in GIST-T1 and GIST-882 cells lines and tissues, compared to HGSMC cells and adjacent tissues. (
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
Pearson’s correlation analysis showing a negative correlation between KIT mRNA and miR-494-3p expression in GISTs tissues.
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
n = 20. (
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
Dual-luciferase reporter assay confirmed that miR-494-3p could competitively targeted wt 3’UTR sequence of KIT (HEK-293T).
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
RT-qPCR (G) and Western-blot (H) assay demonstrated that KIT mRNA and protein expression was significantly and negatively regulated by miR-494-3p expression in GISTs cells.
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
n = 3. *
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
P < 0.05, **P < 0.01, na: no statistical significance.
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
RT-qPCR, reverse transcription- quantitative PCR.
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
OE: OverExpression.
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
shRNA: short hairpin RNA.
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
NC: negative control.
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
OD, Optical Density.
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
circ_SMA4: circ_103870.
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
KIT identified as a functional target gene for miR-494-3p in GISTs. (
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
KIT was simultaneously predicted by three miRNA databases (miRBase, TargetScan, and miRanda). (
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
Schematic representation of potential binding sites between miR-494-3p and KIT. (
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
C-D) RT-qPCR analysis demonstrating the upregulation of KIT mRNA in GIST-T1 and GIST-882 cells lines and tissues, compared to HGSMC cells and adjacent tissues. (
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
Pearson’s correlation analysis showing a negative correlation between KIT mRNA and miR-494-3p expression in GISTs tissues.
PMC11422497
circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway
n = 20. (