PMCID string | Title string | Sentences string |
|---|---|---|
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | Dual-luciferase reporter assay confirmed that miR-494-3p could competitively targeted wt 3’UTR sequence of KIT (HEK-293T). |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | RT-qPCR (G) and Western-blot (H) assay demonstrated that KIT mRNA and protein expression was significantly and negatively regulated by miR-494-3p expression in GISTs cells. |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | n = 3. * |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | P < 0.05, **P < 0.01, na: no statistical significance. |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | RT-qPCR, reverse transcription- quantitative PCR. |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | OE: OverExpression. |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | shRNA: short hairpin RNA. |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | NC: negative control. |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | OD, Optical Density. |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | circ_SMA4: circ_103870. |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | In subsequent assays, RT-qPCR analysis revealed a significant upregulation of KIT mRNA in GIST-T1 and GIST-882 cells (P < 0.05; Fig. 5C) and GISTs tissues (n = 20; P < 0.05; Fig. 5D), compared to HGSMC cells and adjacent tissues. |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | Pearson’s correlation analysis highlighted a negative correlation between miR-494-3p and KIT mRNA expression in GISTs tissues (n = 20; r=-0.51, P = 0.02; Fig. 5E). |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | Additionally, a dual-luciferase reporter assay was conducted to confirm the KIT -miR-494-3p interaction based on the respective binding sites (MRE). |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | The results showed a significant reduction in luciferase activity in HEK-293T cells co-transfected with pmirGLO-KIT-wt and miR-494-3p mimic compared to cells co-transfected with pmirGLO-KIT-wt and miR-494-3p NC (P < 0.05; Fig. 5F). |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | However, no significant change in luciferase activity was observed in cells co-transfected with pmirGLO-KIT -mut and miR-494-3p mimic or pmirGLO-circ_SMA4-mut and miR-494-3p NC (P > 0.05; Fig. 5F). |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | Furthermore, both KIT mRNA and protein expression were found to be significantly and negatively regulated by miR-494-3p in GIST-882 and GIST-T1 cells (P < 0.05; Fig. 5G-H). |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | Moreover, to explore the impact of KIT on GISTs, we successfully constructed lentiviral vector-mediated cellular models with KIT overexpression (KIT OE) and silencing (sh-KIT) (P < 0.05; Fig. 6A). |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | The CCK-8 assay revealed that KIT overexpression significantly enhanced GISTs cell proliferation, while KIT knockdown markedly inhibited GISTs cell proliferation (P < 0.05; Fig. 6B). |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | The Annexin V-FITC/PI assay demonstrated that KIT overexpression significantly suppressed GISTs cell apoptosis, whereas KIT knockdown significantly promoted GISTs cell apoptosis (P < 0.05; Fig. 6C). |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | The cumulative evidence supports KIT as a functional target gene for miR-494-3p and further substantiates the oncogenic role of KIT in GISTs. |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | Fig. 6KIT act as oncogenic role in GISTs. ( |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | Successful establishment of KIT overexpression and knockdown cellular models. |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | The transfection efficiency was assessed by RT-qPCR. ( |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | Cell counting kit-8 (CCK8) assay and (C) Annexin V-FITC/PI assay was performed to analyze the effect of KIT on GISTs cell proliferation and apoptosis. |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | n = 3. * |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | P < 0.05, **P < 0.01. |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | RT-qPCR, reverse transcription- quantitative PCR. |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | OE: OverExpression. |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | shRNA: short hairpin RNA. |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | NC: negative control. |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | OD, Optical Density. |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | circ_SMA4: circ_103870. |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | KIT act as oncogenic role in GISTs. ( |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | Successful establishment of KIT overexpression and knockdown cellular models. |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | The transfection efficiency was assessed by RT-qPCR. ( |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | Cell counting kit-8 (CCK8) assay and (C) Annexin V-FITC/PI assay was performed to analyze the effect of KIT on GISTs cell proliferation and apoptosis. |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | n = 3. * |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | P < 0.05, **P < 0.01. |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | RT-qPCR, reverse transcription- quantitative PCR. |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | OE: OverExpression. |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | shRNA: short hairpin RNA. |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | NC: negative control. |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | OD, Optical Density. |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | circ_SMA4: circ_103870. |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | Rescue experiments were conducted to authenticate the role of the circ_SMA4/miR-494-3p/KIT axis in GISTs. |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | Findings from CCK-8 assays revealed that circ_SMA4 overexpression enhanced GISTs cell proliferation, which was counteracted by treatment with miR-30a-3p mimic. |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | Conversely, circ_SMA4 silencing restrained GISTs cell proliferation, but this inhibition was reversed following treatment with KIT overexpression (P < 0.05; Fig. 7A). |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | KIT mRNA and protein expression, assessed by RT-qPCR and Western blot assays, respectively, significantly increased in the circ_SMA4 overexpression group, but these effects were counteracted by miR-30a-3p mimic treatment (P < 0.05; Fig. 7B-C). |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | Conversely, KIT mRNA and protein expression markedly decreased in the sh-circ_SMA4 group, and these effects were mitigated by KIT overexpression (P < 0.05; Fig. 7B-C). |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | Fig. 7circ_SMA4 promotes GISTs progression by sponging miR-494-3p and activating KIT/JAK/STAT pathway. |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | GIST-T1 cells were co-transfected with the circ_SMA4 OE vector and miR-494-3p mimics. |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | GIST-882 cells were also co-transfected with sh-circ_SMA4 and KIT OE. ( |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | Cell counting kit-8 (CCK8) and (B) RT-qPCR and (C) Western-blot assay showed the effects of circ_SMA4/miR-494-3p/KIT axis on cell proliferation and KIT mRNA and protein expression in GISTs. ( |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | D-E) JAK/STAT signaling pathway can activated by the circ_SMA4/miR-494-3p/KIT axis in GISTs. |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | n = 3. * |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | P < 0.05, **P < 0.01, na: no statistical significance. |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | RT-qPCR, reverse transcription- quantitative PCR. |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | OE: OverExpression. |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | shRNA: short hairpin RNA. |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | NC: negative control. |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | OD, Optical Density. |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | circ_SMA4: circ_103870. |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | circ_SMA4 promotes GISTs progression by sponging miR-494-3p and activating KIT/JAK/STAT pathway. |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | GIST-T1 cells were co-transfected with the circ_SMA4 OE vector and miR-494-3p mimics. |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | GIST-882 cells were also co-transfected with sh-circ_SMA4 and KIT OE. ( |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | Cell counting kit-8 (CCK8) and (B) RT-qPCR and (C) Western-blot assay showed the effects of circ_SMA4/miR-494-3p/KIT axis on cell proliferation and KIT mRNA and protein expression in GISTs. ( |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | D-E) JAK/STAT signaling pathway can activated by the circ_SMA4/miR-494-3p/KIT axis in GISTs. |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | n = 3. * |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | P < 0.05, **P < 0.01, na: no statistical significance. |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | RT-qPCR, reverse transcription- quantitative PCR. |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | OE: OverExpression. |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | shRNA: short hairpin RNA. |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | NC: negative control. |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | OD, Optical Density. |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | circ_SMA4: circ_103870. |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | Moreover, our investigation focused on the downstream JAK/STAT signaling pathway regulated by the KIT gene. |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | Western blot assay results indicated a significant increase in p-JAK and p-STAT protein expression in the circ_SMA4 overexpression group, which was reversed by miR-30a-3p mimic treatment (P < 0.05; Fig. 7D-E). |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | Conversely, p-JAK and p-STAT protein expression notably decreased in the sh-circ_SMA4 group, and these effects were mitigated by KIT overexpression (P < 0.05; Fig. 7D-E). |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | Notably, these alterations did not impact the expression of JAK and STAT proteins. |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | The cumulative evidence suggests that circ_SMA4 promotes GISTs progression by sponging miR-494-3p and activating the KIT/JAK/STAT pathway. |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | The in vivo mice xenograft tumor model, as depicted in Fig. 8A, was established to delve deeper into the oncogenic role of circ_SMA4 in GISTs. |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | Following this, 1 × 106 GIST-T1 and GIST-882 cells, fluorescently labeled, were subcutaneously injected into the armpits of nude mice. |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | Upon comparative analysis with the control group, noteworthy increases were observed in the tumor growth rate, tumor weight, and tumor volume in the circ_SMA4 overexpressing group, whereas these parameters experienced a significant reduction in the sh-circ_SMA4 group (P < 0.05; Fig. 8B-C). |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | The proliferative index of GIST-T1 and GIST-882 cells in vivo was assessed using Ki-67 staining in xenograft tumor samples. |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | The results highlighted a substantial increase in the percentage of Ki-67-positive cells in the circ_SMA4 overexpressing group and a corresponding decrease in the sh-circ_SMA4 group (P < 0.05; Fig. 8D). |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | Fig. 8Oncogenic role of circ_SMA4 in GISTs progression in vivo. ( |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | Establishment of xenograft tumor model in nude mice. |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | After 5 weeks of feeding, the mice were euthanized, and nude mice were taken out to measure their size and weighed. ( |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | Xenograft tumor growth curves and (C) Xenograft tumor weight revealed that circ_SMA4 promotes GISTs cell proliferation in vivo. ( |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | The percentage of Ki67-positive cells in xenograft tumors was measured. ( |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | TUNEL assay was performed to determine the cell apoptosis rate in Xenograft tumors. |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | The expression of circ_SMA4 (F), miR-494-3p (G) and KIT mRNA (H) in Xenograft tumors were detected by RT-qPCR assay.n = 3. * |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | P < 0.05, **P < 0.01, na: no statistical significance. |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | RT-qPCR, reverse transcription- quantitative PCR. |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | OE: OverExpression. |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | shRNA: short hairpin RNA. |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | NC: negative control. |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | OD, Optical Density. |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | circ_SMA4: circ_103870. |
PMC11422497 | circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway | Oncogenic role of circ_SMA4 in GISTs progression in vivo. ( |
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