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OTAR3088
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BioData-CellLine_annotated

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PMC9429973
ScRNA-seq analysis revealed that transcription factor YY1 was significantly highly expressed in follicular helper T cells (Tfh) of RR-AITL patients, which promoted the proliferation and drug resistance of AITL cells (Fig A-D), consistent with the results of IMC (Fig E,F).
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PMC9429973
Chelation therapy had been utilized by 20/23 (87.0%) splenectomized adults and 2/4 (50.0%) non-splenectomized adults, while 15/15 (100%) splenectomized pediatric pts and 13/14 (92.9%) non-splenectomized pediatric pts had received chelation therapy.
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PMC9436459
0.5 μg/mL (5-FU)Morushalunin (4)P-3880.7 μg/mL –Chalcomoracin (5)A5495.5 μg/mL 0.2 μg/mL (5-FU)A27805.7 μg/mL 0.7 μg/mL (5-FU)Bel-74025.6 μg/mL 0.5 μg/mL (5-FU)BGC-8235.6 μg/mL 0.7 μg/mL (5-FU)HCT-87.0 μg/mL 0.5 μg/mL (5-FU)LNCaP8 μM –MDA-MB-2316 μM –PC-36 μM –P-3885.46 μM ; 1.7 μg/mL –Mulberrofuran E (9)A5495.8 μg/mL 0.2 μg/mL (5-FU)A27805.7 μg/mL 0.7 μg/mL (5-FU)Bel-74026.6 μg/mL 0.5 μg/mL (5-FU)BGC-8235.9 μg/mL 0.7 μg/mL (5-FU)HCT-86.7 μg/mL 0.5 μg/mL (5-FU)Mongolicin C (24)A5496.6 μg/mL 0.2 μg/mL (5-FU)A54916.8 μM –A27806.0 μg/mL 0.7 μg/mL (5-FU)AGS17.5 μM –Bel-74027.2 μg/mL 0.5 μg/mL (5-FU)BGC-8236.1 μg/mL 0.7 μg/mL (5-FU)HCT-86.7 μg/mL 0.5 μg/mL (5-FU)Hela17.1 μM –HepG217.4 μM –HL-6017.1 μM –Australisine B (25)A5495.8 μg/mL 0.2 μg/mL (5-FU)A27805.7 μg/m L 0.7 μg/mL (5-FU)Bel-74026.1 μg/mL 0.5 μg/mL (5-FU)BGC-8235.4 μg/mL 0.7 μg/mL (5-FU)HCT-86.8 μg/mL 0.5 μg/mL (5-FU)Mulberrofuran Q (30)A549n.a.
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PMC11190238
This could provide information to correlate between chromatin accessibility and gene expression in EMT models, as well as elucidate the possible TFs that orchestrate the accessibility changes at the EMT genes at different EMT states.
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PMC11078693
Combine the suspensions from all the 50 mL tubes into a single 15 mL conical tube (collecting about 10 mL of volume).e.
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PMC5839394
AgNPs-EPS treatment did not affect significantly the migratory capability of SKBR3 cells.
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PMC11537649
Expression of NEAT1 in Hacat (A) and A375 cells (B) was detected by qRT-PCR. (
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PMC11766350
A further category, short hairpin RNAs (shRNAs) are single-stranded RNAs with self-complementary ends; a hairpin loop at the center allows the molecule to fold back on itself into a double-stranded RNA.
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PMC9429973
All patient achieved early response (R or CR) with prednison and eltrombopag at 8 days, eight (72.7%) achieved CR, and three (40%) achieved R. CR at 1 months (platelets≥100×10/ L) was achieved in 81.8% of patients.
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PMC9512971
Considering the adherence of the target patient population, we assumed that qid administration of camostat mesilate (morning, midday, evening, and before bedtime) would be acceptable.
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PMC11721064
Data are from three independent experiments. *
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PMC8759873
The pl9 protein has a similar function to the p30 protein.
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PMC8427838
In an alternative approach, we used 786-0 cells expressing either empty vector (EV) or TMIGD1 and determined the binding of endogenously expressed moesin with TMIGD1 in 786-0 cells via immunoprecipitation with the anti-TMIGD1 antibody.
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PMC10170482
Indeed, comparative analysis of cells cultured in either stiff MC or soft 3D CS conditions revealed that cell growth in 3D CS conditions makes both cell lines more susceptible to HFLP laser-induced toxicity (Figure 5F).
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PMC11705862
IRIS-2 (Ref.
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PMC10999934
For example, Liao et al. stated that ovarian cancer stem cells have the ability to endure stressful situations, specifically low oxygen levels, and could play a role in chemoresistance .
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PMC11317131
We demonstrated activity in diverse cultured cell lines and primary human fibroblasts.
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PMC9964635
Various N-arylated 5-(1-(4-isobutylphenyl)ethyl)-1,2,4-triazole-2-yl-2-sulfanyl-coupled acetamide compounds were prepared in good yield by thoroughly mixing 4 (0.02 mol) with an equimolar amount of N-alkyl/aryl 2-bromoacetamides 6a–f using DMF and NaH (0.01 mol).
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PMC10079526
In a Namalwa orthotopic xenograft model, significant in vivo tumor outgrowth reduction was obtained with 5-Aza-2’ and TAK981 combination therapy.
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PMC11541409
: p. 3918-3928.This reference is of outstanding importance because it reports that ripretinib has the similar effcicay with sunitinib as a second line therapy drug for GIST patients after imatinib failure.
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PMC10723784
The cells were grown in complete media, RPMI and maintained with 5% CO2 at 37°C under humidified conditions.
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PMC11672881
To validate the RNAseq data, we performed qPCR analyses for the GPX3, CYP4F11, CASP-3, H1F1, and HSPB8 genes (Figure 6B).
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PMC7504302
Included among the mutated genes in these pathways are APC, ARID1A, BMPR1A, CHEK2, DVL1, EPHB1, FBXW7, KDR, MAP2K1, PDGFRA, PTEN, RB1, SMARCA4, SMARCB1, HRAS, NRAS, and WRN , whose genetic alterations have also been found in lung adenocarcinomas , colorectal , and breast cancers .
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PMC11638255
TGF-β serum and TME data are presented as mean ± SEM, n = 7 (both groups) biological replicates, two independent experiments.
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PMC11612626
Proteasome subunit α type-1, encoded by PSMA1, is essential to the assembly of 20S proteasomes.
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PMC11409031
Subsequently, the optical density (O.D) of 450 was determined using a microplate reader from BioTek (USA).
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PMC11078693
Using the cut Pasteur pipette, position the glass horizontally in the tilted tube, while still submerged in the liquid (Figure 1).Figure 1Stepwise demonstration of removal of a 25 mm cover glass from a flat bottom 50 mL tube(A) 25 mm cover glass stained purple for visualization purposes at the bottom of a tube.(B) Plastic transfer pipette tip before (center) and after (right) being cut with scissors (left) to create a tool for gentle detachment of the cover glass from the bottom of the tube.(C) After slow decanting of 40–45 mL of the liquid, the cut pipette is used to grab the edge of the glass.(D) Cover glass is repositioned by the cut pipette to make it accessible to the tweezers.(E) The tweezers gently engage the cover glass.(F) The cover glass is lifted out of the tube by the tweezers.d.
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PMC6102174
Hepatitis B infection caused by the hepatitis B virus (HBV) can become either acute or chronic diseases.
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PMC11802855
C Probability of pathological fracture in patients with different CXCL7 expression levels.
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PMC9429973
Approximately 346 patients will be randomized (1:1) to magrolimab+AZA (experimental arm) or physician’s choice of VEN+AZA or 7 + 3 chemotherapy, based on patient fitness.
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PMC3813807
One notable point observed in this study was that the upregulation of miR-373 and the downregulation of TNFAIP1 was all in grade I, II and III gastric adenocarcinoma tissues.
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PMC11754291
Microscopic images of keratinocyte cultures seeded on a feeder layer of mitotically inactivated fibroblasts, captured at 10X magnification.
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PMC11200978
As such, further investigation is necessary to determine if different modes of cell death are active at other time points post freeze.
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PMC9429973
Similar 5-year cumulative incidences in validation dataset were 66% (61, 71%), 45% (38, 52%) and 21% (12, 30%) (p for trend<0.001, Figure D).
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PMC11519567
B Representative images of BJ fibroblasts expressing SS18-EGFP and SS18-SSX1-EGFP for immunofluorescence detection of H2AK119ub after 3 h treatment with DMSO and 37.5 μM PRT4165.
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PMC11578343
To create the PDMS mold, standard soft‐lithography was employed.
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PMC11474209
90 % of untreated sewage is thrown into bodies of waterbodies, resulting in the annual death toll from illnesses carried by tainted water of almost 5 million people, hurting the ecosystem.
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PMC11612508
As the temperature was increased to 25 ℃, a sodium hydroxide solution (1 mol L) was slowly introduced to adjust the pH to a range of 9–10, and the reaction was allowed to proceed for another 4 h. Finally, the resulting black products (GO/CS/IO microspheres) were gathered using a magnet, washed multiple times with petroleum ether, deionized water, and ethanol in that order, and then dried in a vacuum.
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PMC11045125
The extracts used are the same as those in Fig 5A with the same actin blot.
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PMC11488203
GOseq-based Wallenius non-central hyper-geometric distribution which could adjust for gene length bias, was implemented for GO enrichment analysis.
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PMC9118379
Thus, it is essential to exclude variant peptides that do not contain the variant event.
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PMC9581083
Substances found in I. indigotica root include indican (indoxyl-β-d-glucoside), indigo, indirubin, β-sitosterol, γ-sitosterol and sinigrin.
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PMC11585254
Membranes were blocked with 5% (w/v) milk in Tris-buffered saline (TBS, 20 mM Tris-Cl, pH 7.5, 150 mM NaCl) containing 0.05% (v/v) Tween-20 (RPI, 9005-64-5) (TBS-T).
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PMC7887261
i Representative histograms of (g). *
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PMC10213179
Ethics approval was provided by Catalan Government Animal Care Committee (permit no. 9745).
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PMC11461833
Our study demonstrated that the overexpression or knockdown of STXBP5 in HA-progerin-expressing HEK293 cells caused changes in TEs.
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PMC4112127
CpGenome™ Universal Methylated bisulfite-treated human genomic DNA DNA (Chemicon, Billerica, MA) was used as a positive control for MSP.
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PMC11407042
Seed 5×10 cells into a 10 cm dish with a total volume of 8 mL.Note: A seeding density of 6 × 10–7×10 cells/cm is recommended.
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PMC6133382
Based on PG9 binding studies, the MGAT genes from selected cell lines were amplified by PCR and sequenced. (
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PMC9693627
The selected sgRNA spacer cDNA sequences (5′-CACCGCAAAATCTGCAGCGCCTGCG-3′ and 5′-AAACGCAGGCGCTGCAGATTTTGCG-3′ for sgRNA1 and 5′-CACCGGCCCTCTCGGAGGTATCCG-3′ and 5′-AAACCGGATACCTCCGAGAGGGCC-3′ for sgRNA2) were synthesized (Evrogen, Moscow, Russia) and inserted between BbsI sites in the pU6-gRNA vector containing sgRNA scaffold (kindly provided by Dr. Boris Skryabin, University of Munster).
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PMC9429973
J. M. Bergua-Burgues, R. Rodríguez-Veiga, I. Cano, F. Vall-llovera, A. García-Guiñon, J. Gómez-Estruch, M. Colorado, I. Casas-Avilés, J. Esteve-Reyner, M. V. Verdugo, F. Ramos, M. Valero, E. Acuña-Cruz, B. Boluda, L. Torres-Miñana, J. Martínez-López, E. Barragán, R. Ayala, D. Martínez-Cuadrón, P. Montesinos Hospital San Pedro de Alcántara, Cáceres; Hospital Universitari i Politècnic La Fe, Valencia; Hospital Universitari Mútua Terrassa, Barcelona; Hospital Arnau de Vilanova, Lleida; Hospital Clinico Universitario Virgen de la Arrixaca, Murcia; Hospital Marqués de Valdecilla, Santander; Hospital Clinic Barcelona, Barcelona; Hospital de Jerez, Jerez de la Frontera; Hospital Clinico de León, León; Hospital Arnau de Vilanova, Valencia; Hospital 12 de Octubre, Madrid, Spain Background: Venetoclax (VEN) combined with Azacitidine (AZA) or Low Dose Cytarabine (LDAC) has emerged as new therapeutic option for unfit acute myeloid leukemia (AML) patients (pts), but primary resistance is observed in roughly 40% of them, while relapses occur in the vast majority.
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PMC11001582
e, Quantification of Nissl-stained motor neurons in lumbar spinal cord region L3–L5 in WT, (GR)400 and (PR)400 mice at 12 months of age.
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PMC11588008
Gently disperse the cell suspension, transfer it to 10 mL centrifuge tubes using a pipette, centrifuge at 1,000 rpm for 5 min, and discard the supernatant.
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PMC9429973
The main event of interest was the occurrence of death.
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PMC10958426
After quality control, we obtained a total of 101,065 cells, among which 52,063 cells in-house data and 49,002 cells are from public data (Fig. S1A).
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PMC9429973
As expected, HJB score was significantly higher at check-ups in splenectomized than in non-splenectomized SCA-patients, P<0.001 (Figure 2).
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PMC11541409
These mutations confer resistance to imatinib, with both in vitro studies and clinical data supporting this observation.
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PMC11482552
In their study, CCR5 as a single-copy human gene was used to determine the cellularity of human cells from clinical samples to achieve the absolute quantification of proviral HIV-1 DNA .
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PMC11098378
Strikingly, we found the codon-optimized IpgD expressed in immunoblots (Fig 3B) and enhanced the replication of all four arboviruses (Fig 3C–3F).
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PMC11621493
Statistical comparison in (A, B, E, F, G, H) was performed with multiple unpaired two-tailed Student’s t test followed by Bonferroni posthoc analysis.
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PMC10094992
An amount of 20 ng of cDNA was used to perform RT-PCR amplification of mRNA.
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PMC11578343
Intriguingly, we observed that a significant fraction of single cells had an elastic G′ that mirrored the average G′ of untreated cells, possibly indicating that these cells recovered more quickly from actin depolymerization.
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PMC10452486
They point out that such covalent crosslinking within and between HCs plays a role in determining structural configurations and ligand-receptor interactions of the proteins.
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PMC6803987
Slightly modified from the method of Huang et al. , short-term toxicity studies were conducted in ducks.
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PMC8735881
Therefore, the results suggested that GPI-10E8 can impair HIV-1 Env processing and viral infectivity in transduced cells, consistent with the effect of GPI-m36.4 described previously.
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PMC6222726
Most of these compounds were fatty acids and fatty acid esters, but they revealed the presence of podophyllotoxin (19) (Figure 3) .
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PMC11082662
Our findings further show that SMPDL3B may be involved in the signaling pathway upstream of ACER2.
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PMC11794568
Subsequently, the cells were washed twice, analyzed under a fluorescence microscope and images were captured.
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PMC9878562
In line with this, VAL-ko cells, which do not express CCR7 ( Figure 1A ) did not migrate towards CCL19 ( Figure S1G ).
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PMC2614416
Number of microscans: 4; Maximum Injection Time (ms): 200; Isolation width (m/z): 3; Normalized Collision Energy (%): 35; Activation Q: 0.250; Activation Time (msec): 30.00; Scan Range: 300–1800 m/z.
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PMC10380508
The role of PAX6 expression in RCC remains unclear, although its expression in normal brain tissue is associated with cell differentiation and migration .
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PMC8751435
However, its clinic application is still controversial due to the concern that cytotoxic effect and targets of CME are not validated.
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PMC11351758
The MPT pore is a mega channel complex that contains an adenine nucleotide translocase (ANT), cyclophilin-D (CyP-D), and a voltage-dependent anion channel (VDAC).
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PMC11731614
Isolated extracellular vesicles from SEC fraction 2/3 are functionally retrogradely trafficked by DRG neurons in vitro.
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PMC11240052
For example, circ-NOLC1 promotes ovarian cancer tumorigenesis and development by binding and modulating ESRP1, CDK1, and RhoA levels (19).
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PMC11532793
Illumina short-read paired-end RNA-seq libraries were obtained from NCBI Gene Expression Omnibus (GEO) series GSE172421.
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PMC8414691
These bands may be compatible with the three predicted SRCAP isoforms of 343, 337, and 327 kD. In fact, although proteins with minimal size differences should not be separated at high molecular weights, it is well known that the predicted molecular weight of a given protein not always corresponds to that found experimentally by SDS-PAGE.
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PMC6442998
RNA was reverse transcribed with 200 units of M-MLV Reverse Transcriptase (Invitrogen, Eugene, Oregon, USA) in a reaction containing 1μg of random primers (Amersham Bioscience, Piscataway, NJ, USA), 0.01M each dNTP, 1x First-Strand buffer and 0.1M dithiothreitol followed by heat deactivation.
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PMC10813895
Tumor development in BRCA1 knockout mice was reduced by inhibiting RANK/RANKL signaling using Rank:Brca1:p53 triple-knockout mice , indicating that activation of the RANK/RANKL signal promotes tumor development.
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PMC9429973
Also, MRD-negativity status can be considered more valuable on prognosis than CR.
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PMC11474209
Abbreviations: ATP: Adenosine triphosphate; Bax: Bcl-2-associated X protein; Bcl-2: B-cell leukemia/lymphoma 2 protein; Bid: BH3 Interacting-domain death agonist; cGAS: Cyclic GMP-AMP synthase; Cyt C: Cytochrome complex; DNA: Deoxyribonucleic acid; DNA-PK: DNA-dependent protein kinase; ETC: Electron transport chain; HRR: Homologous recombination repair; IFN β: Interferon beta-1; IFS: Intermediate filaments; IRF3: Interferon regulatory factor 3; MCLR: Microcystin-Leucine arginine; MC-LR: Microcystin-Leucine Arginine; MFS: Microfilaments; MMP: Mitochondrial membrane potential; MPT: Membrane-permeabilization transition; MTs: Microtubules; NAD+: Nicotinamide adenine dinucleotide; NADH: Nicotinamide adenine dinucleotide; NF-kβ: Nuclear factor kappa-light-chain-enhancer of activated B cells; OATP: Organic anion transporter peptides; OATP: Organic anion transporter peptides; OS: Oxidative stress; PARP1: Poly (ADP-ribose) polymerase 1; PP1: Protein phosphatase-1; PP2A: Protein phosphatase 2A; ROS: Reactive oxygen species; STING: Stimulator of interferon genes.
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PMC8916024
This finding confirmed that C. chinensis can ingest cyanobacteria, which provides possibilities for water purification and bloom control in the future.
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PMC11354225
However, EGCG at 40 µM significantly increased cell proliferation percentage.
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PMC11277157
Total RNA was extracted from cell culture with TRIzol (Thermo-Fisher Scientific, Waltham, MA, USA), and RT was performed using a Ready-To-Go first-strand synthesis kit (Cytiva, Marlborough, MA, USA) according to the manufacturer’s instructions.
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PMC11541409
In imatinib-resistant GIST 48R cells with secondary mutations in KIT (V560D + D820A), overexpression of fatty acid synthase (FASN) plays a critical role in promoting growth and migration, as well as sustaining resistance to imatinib.
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PMC11138140
Consistent with this, direct stimulation of isolated primary rat cardiomyocytes with the sympathetic neurotransmitter norepinephrine induces hypertrophy in serum-free culture .
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PMC11727062
Artemisinin exhibits a range of pharmacological effects, including anti-inflammatory, antimicrobial, antiparasitic, antiviral, and antitumor activities (Guo et al. 2023).
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PMC11471157
Yumeka Mine: Investigation.
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PMC9429973
The median age of patients was 17.1 years (range from 3.5 years to 34.1 years).
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PMC11429241
By day 4, the best 3D cultures were observed with a scaffold pore size of 55 µm, as cells fully covered the scaffold, indicating that this pore size was ideal for the SKOV3 cell line.
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PMC9479186
Multiply the intensity score and the percentage of positively stained cells to get the overall score.
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PMC11306019
Since it is known that PGG and EGCG do not have antagonistic activity against non-boronic acid–based PIs (Modernelli et al., 2015; Tseeleesuren et al., 2018b), our research collectively suggests that patients undergoing treatment with IXZ or BTZ should be cautious about their intake of foods rich in gallotannins or polyphenols.
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PMC11731161
As illustrated in Fig. 1D, MG-132 effectively reversed the SEL-induced degradation of XPO1 in a dose-dependent manner.
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PMC11782508
Emerging chemotherapeutic approaches include utilizing bacteria and their metabolites for cancer treatment.
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PMC11786704
CLSM images of PC capsules. (
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PMC9428827
No-alpha mutein induces a potent antitumor effect in four different tumor models and is able to change CD8MP/Treg balance in tumor-bearing mice in the spleens.
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PMC11676674
In Sardinian folk medicine, a compress created from fresh leaves is externally applied for healing wounds, skin disorders, and pain relief; the infusion is also employed for addressing tick bites .
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PMC7840816
In addition, knockdown of SOX9 significantly inhibited PTC proliferation, colony formation, migration, and invasion, as well as epithelial–mesenchymal transition (EMT) phenotype in TPC-1 and BCPAP cells.
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PMC11763111
Viable donor CAR-T cells were mixed with fourfold alloreactive PBMC cells.
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PMC11467964
Locations of CNV alterations in BMRGs on 23 chromosomes. (
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