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BioData-CellLine_annotated

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PMC10114490
Red line marks FDR = 0.05 hTERT-transduced cell lines are phenotypically stable without senescence traits.
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PMC11411131
On the basis of our initial results, we speculated that the compromised Sec incorporation caused by MeHg could be used to construct a sensor vector.
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PMC9429973
The study was approved by the local ethical committee.
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PMC11422150
These findings suggest potential benefits of hAMSC treatment for SCI patients in the future.
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PMC11593031
Finally, as highlighted in Table 1, Neuro-2a is well suited as a murine model for advanced NBs without MYCN amplification.
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PMC9429973
We report a series of four cases of acquired AA developing in patients, who had received an mRNA-based SARS-CoV-2 vaccine.
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PMC10507284
To construct a TROAP‐derived prognosis evaluation model, we first categorized STS patients into low and high TROAP expression groups.
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PMC10079526
Subsequently, cells were fixed, stained with crystal violet and quantified.
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PMC11599565
Some markers were not detected (red triangles): NeuroN, SOX2 in normal cells and CD24 and EpCAM in “twin” cells.
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PMC11673902
These applications demonstrate the important role of single-cell mechanical measurement techniques in advancing biomedical research and clinical practice.
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PMC11482552
The C-C Motif Chemokine Receptor 5 (CCR5) gene has been employed in the OncoPredict HPV assays (Hiantis Srl, Milan, Italy) as an independent Quality Control (QC) reaction to assess sample adequacy through the quantitative determination of the single-copy human CCR5 gene, also allowing a more reliable HPV viral load determination by normalization according to sample cellularity .
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PMC11747467
Recently, MIBC consensus subtypes were established based on a prior classification system, dividing MIBC into six subtypes: basal/squamous (Ba/Sq), luminal unstable (LumU), luminal nonspecified (LumNS), luminal papillary (LumP), neuroendocrine-like (NE-like), and stroma-rich (12).
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PMC5261804
Also, the smoothing can be seen as a denoising approach.
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PMC11271278
P values were derived from two-sided t-tests.
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PMC11777207
Monocytes traffic from the blood to inflamed tissue via CCR2, where they differentiate into monocyte-derived DCs (moDCs) (13).
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PMC11746948
Scale bar, 10 μm.
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PMC9429973
Newly diagnosed DLBCL patients over 60 years in 2008-2019 treated in the hematology department of Sfax were included.
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PMC11773391
The activities of Renilla luciferase in MGMT‐Luc were determined following the Renilla Luciferase Reporter Gene Assay Kit protocol (Beyotime, RG017) as previously reported .
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PMC11352877
The RL-95-2 epithelial cell line was obtained from a moderately differentiated grade 2 adenosquamous carcinoma of the endometrium.
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PMC3813807
To confirm the expression level of miR-373 in gastric adenocarcinoma tissue and normal gastric tissues, total RNA was extracted from 15 gastric adenocarcinoma samples, consisting of five grade I, five grade II and five grade III gastric adenocarcinoma tissues, 15 matched normal tissues and three human gastric carcinoma cell lines, and then qPCR was performed to analyze the expression profile.
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PMC11684821
We set out to generate further T cell clones that responded to cancer lines via MR1 to determine whether most donors had T cells with this property.
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PMC11453378
We have assessed the expression of 11bHSD1L in the non-human primate marmoset and show that 11bHSD1L mRNA and protein levels are highest in regions of the brain and reproductive organs, which parallels expression patterns in human tissues.
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PMC10900886
Immune cells are susceptible to infection of other members of Picornaviridae.
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PMC11252033
Also, a reduction in incidence of ovarian cancer has been observed in patients who take ASA regularly (Trabert et al., 2014).
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PMC11740907
Conserved H-bond interactions with L83 in the hinge region are crucial, with POM forming additional bonds with Q85 and D86 in the solvent-exposed region.
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PMC11064533
On LB agar plates, 20 µL spots of the dilutions were pipetted in triplicates for each well.
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PMC8143558
The antibacterial efficacy of saponins that were extracted from the leaves of Tephrosia vogelii Hook.
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PMC11746948
A total of 50 µL of the RKO cancer cell mixture was slowly injected into the cecal wall using an insulin needle, and the injection site was inspected to ensure that the mixture did not leak into the cecal lumen or around the cecum.
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PMC8469018
The results of the first published phase I study showed that the use of leflunomide resulted in low toxicity with simultaneous stable disease in over 90% of patients .
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PMC11026382
e Correlation between intracellular TYMS concentrations determined by model fit and lysate assay.
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PMC10933092
All mA methylated transcripts were divided into seven groups based on the number of peaks per transcript.
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PMC11650848
Analysis of published genome-wide studies indicated other SNPs in linkage disequilibrium with the mQTL were also associated with neurodevelopmental outcomes.
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PMC11128598
Our data provide a rationale for the clinical investigation of CQ in combination with DSB inhibitors for the treatment of different solid tumors.
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PMC9429973
Infection caused by herpes viruses was detected in 5 patients (6%).
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PMC11730320
The variant was also validated in a clinical laboratory (Fulgent Genetics).
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PMC11092382
Many modern pharmacological studies have revealed its multiple bioactive effects, such as anticancer (Luo et al., 2019), anti-inflammatory (Gao et al., 2012), antiviral (Gao et al., 2013; Sang et al., 2017), analgesic (Wang et al., 2021b), and organ protection (Li et al., 2014; Hou et al., 2020) or addressing vessel dysfunction (Fang et al., 2020) effects.
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PMC9429973
This pathway of degradation is the target of proteasome inhibitors.
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PMC11290772
The remaining live cells were then incubated with 10 μl CCK-8 solution per well at 37 °C for 2 h. The absorbance, indicating the optical density (OD) value, was measured at 450 nm using a Microplate Reader (PT-3502B, Potenov, Beijing, China).
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PMC11656657
However, this tumor control was still statistically significant compared to the un-transduced (NT) T-cell condition.
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PMC9429973
Haematologica (2019) 104(4):749).
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PMC11683240
A–B, for the competition study based on the sequential ADP-ribosylation of Gαi six different treatment options using PT (10 ng/ml) and α1AT (100 μM) or the respective amount of solvent (H2O) were performed in parallel.
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PMC11489351
Scatter plot (mean ± SEM) from five biological replicates.
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PMC11765988
In patients undergoing long-term immunosuppressive treatment, such as those with organ transplants, viral and non-viral agents elevate the risk of virus-related cancers and B-cell non-Hodgkin lymphoma.
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PMC9429973
WVT078 demonstrated potent anti-MM activity and efficient T-cell activation in preclinical models, and was well tolerated in cynomolgus monkeys.
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PMC10125312
We also studied liver and kidney derived cells as key tissues that, as part of the mononuclear phagocytic system and renal clearance, respectively, will be responsible for a high sequestration of nanoparticles after intravenous administration.
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PMC11201989
Third, both primary cilia and immune synapse formation involve actin reorganization.
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PMC5810978
Primary intestinal epithelial cells were seeded into T25 flasks.
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PMC11779605
Furthermore, we demonstrated that higher FGF7 levels in serum were associated with worse ovarian cancer patient outcome.
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PMC10809689
a.) Displays changes in glutamate concentration (µmol/L) in control, PMA, and PG24 groups in the THP-1 cell line. (
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PMC9646302
However, the specific molecular mechanisms underlying ccRCC have not been fully studied or demonstrated.
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PMC9872547
The results showed that the E7 protein level was reduced in nano-curcumin-treated HeLa cancer cells after 48 hours (P < 0.05).
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PMC10938377
More recently, we demonstrated that conjugating a RAPTA group to an auranofin-like group, ([Au(4-diphenylphosphanyl-benzoic acid)X], AuDPPBX; where X = Cl), via a long polyethylene glycol (PEG) linker yields a potent heterobimetallic compound that crosslinks the H2A–H2B dimer with the H3–H4 tetramer in chromatin.
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PMC9429973
These results show that epcoritamab + R-CHOP has a manageable safety profile.
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PMC11787381
2Effects of bambuterol after treatment with AβO in a primary culture of hippocampal neurons on survival of MAP-2 neurons, neurite network, and phosphorylation of Tau.
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PMC9429973
Results: Trial in progress.
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PMC10748106
Simple iridoids are iridoids that have a simple modification of the cyclopentane ring, and such modifications could be hydroxyl, acyloxy, keto, epoxy, chlorine, and olefins.
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PMC11574271
Migration through the extracellular matrix is an essential component of cell migration, with matrix metalloproteinases (MMPs) playing a crucial role in degrading the matrix to promote tumor cell metastasis .
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PMC9429973
Summary/Conclusion: N/A Y. Zhang, Y. Hou, X. Zhou, L. Sun, W. Wang, Y. Wo, Y. Sun, Q. Xu, P. Liu Department of Hematology, Zhongshan Hospital, Fudan University; Department of Hematology and Oncology, Minghang Hospital, Fudan University, Shanghai; Department of Hematology, Wuxi People′s Hospital Affiliated to Nanjing Medical University, Wuxi; Department of Hematology, Zhongshan Hospital Qingpu Branch, Fudan University; BeiGene, Shanghai; Canhelp Genomics Research Center, Hangzhou, China Background: Diffuse large B-cell lymphoma (DLBCL) shows remarkable molecular heterogeneity that can demonstrates different clinical outcomes.
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PMC11348300
The second major finding is that contrast decreases with ALA incubation time, accompanied by a decline in sensitivity to palpation.
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PMC10734950
After screening 1300 compounds, a novel thiophene compound was found to elicit potent cytotoxicity on the Acute Lymphoblastic Leukemia (ALL) CCRF-CEM cell line using the Differential Nuclear Staining (DNS) assay .
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PMC9429973
The distribution of the top 10 out of the 21 common haplotypes in the combined cohort was 0.63%-1.38%.
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PMC11269792
Although this study has partially elucidated the function of circAPP in GIST, further research is required in order to develop effective GIST treatments.
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PMC3931643
Several studies have shown growth-suppressive effects of rapamycin, PI3K inhibitors or dual PI3K/mTOR inhibitors in B lymphoma cell lines –. However, the effects of selective mTOR kinase inhibitors (asTORi) on DLBCL have not been reported.
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PMC10317042
SOX10 regulates the expression of EWSR1::ATF1.
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PMC8427838
B Cell lysates from the same cell groups were blotted for acetylated-α-tubulin, total α-tubulin and TMIGD1.
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PMC10203589
Regarding the mechanism of action of FGF18 with FGFR.
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PMC11754436
The cells to be tested (~ 1,000 cells/well) were inoculated in 96-well plates (three replicate wells per group), with a total medium volume of 100 µl.
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PMC10798140
C NMR (126 MHz, DMSO-d6) δ 156.85, 155.20, 153.30, 138.48, 133.71, 133.01, 130.65, 127.13, 124.80, 124.26, 123.44, 119.95, 119.36, 114.70, 85.35, 65.94, 47.08.
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PMC9917080
Necrosis was registered only in single astrocytes at a SeNPs concentration of 5 μg/mL (Figure 4B,E; Supplementary Figure S8).
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PMC11434983
After thorough shaking, the absorbance of each well was measured in an ELISA reader, as previously described.
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PMC11486946
For example, oxidative processes in cells are induced by various compounds (e.g., broxyquinoline) and have been suggested to affect EGFR signaling.
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PMC10589262
Sections were incubated with individual primary antibodies at 4 °C overnight and with the appropriate secondary antibody at room temperature for 1 h. Peroxidase activity was revealed using 3,3-diaminobenzidine (Vector Laboratories), and sections were counterstained with hematoxylin (Vector Laboratories).
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PMC11190238
Lastly, the formation of EMT-TF centric enhancer-promoter interactions, via loop extrusion model, within the TADs is required for activation of EMT gene transcription.
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PMC9429973
CALR type 1 mutation was detected only in 12%, while any high-molecular risk (HMR) mutation was present in 31% (8% for ≥2 HMR mutations).
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PMC9792775
Cell viability of A-204 cells treated with PTX. (
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PMC11615828
The red, green, and blue lines represent the percentage of LAMP1‐vesicles with confined behavior, directed movement, and free diffusion, respectively.
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PMC9341513
With this information, we could then perform simulations of the rearranged genome, which we denote hg19_z138.
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PMC11271800
Similarly, CCL2 activation and upregulation in GIST lead to TAM recruitment, which in turn affects the TME and promotes tumor progression and metastasis.
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PMC11740508
The second allele had a 33 base pair deletion that removed aa 86–96 from the transactivation domain.
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PMC11026382
Each curve represents the mean of three replicates,the shaded region describes standard deviation.
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PMC11267830
h Hematoxylin and eosin staining assessment of bone marrow, liver, and spleen in the two groups In vivo experiments validated the role of RBM39 in T-ALL.
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PMC10006224
Then, each barcoded sample was blocked in flow buffer (0.1% Igepal CA-630, 6.5 mM Na2HPO4, 1.5 mM KH2PO4, 2.7 mM KCl, 137 mM NaCl, 0.5 EDTA pH 7.5, 4% non-fat milk) for 5 min and consecutively incubated with primary and secondary antibodies, also diluted in flow buffer, for 1 h each.
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PMC9429973
Image: Summary/Conclusion: We found a combination of epigenetic and transcriptomic changes associated with Ven resistance development in MCL cell lines; however, the observed epigenetic alterations might not drive Ven resistance alone, since pretreatment with epigenetic drugs did not affect Ven sensitivity.
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PMC10538569
Migration of GPI-GFP from GPI-GFP transduced CEMss cells to iDCs. (
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PMC8557138
Nude mouse strains expressing GFP under various endothelial-specific gene promoters such as Nestin regulatory protein, endothelial nitric oxide synthase (eNOS), and Tie2 have been successfully developed and are widely being used to study tumor vessel characteristics and screening anti-angiogenic drugs (Okabe et al. 1997; Staton et al. 2009).
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PMC11765879
It triggers apoptosis in cancer cells and suppresses the generation of cancer stem cells, which are mainly involved in the recurrence of the disease .
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PMC10956161
In conclusion, this current study found that the PRDX6 gene is highly expressed in lung adenocarcinoma and that it can promote the proliferation of NCI-H1395 cells.
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PMC11604768
We detail how this tool isolates and defines discrete signaling pathways associated with specific GPCRs, elucidating their transcriptional signatures.
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PMC11786156
The mean extravascular Ki-67 index (87.0 ± 6.5%) was significantly higher than the mean intravascular Ki-67 index (72.2 ± 20.5%) among concordant double-positive cases (P = 0.021, corrected P = 0.047, Student’s t-test with Holm correction) (Figure 3a).
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PMC11549062
Immunohistochemistry of PDGFR‐β and Caspase‐3 was performed, and the results showed higher expressions of PDGFR‐β and Caspase‐3 in vulnerable plaque compared to stable plaque (Figure 1A,B).
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PMC5854676
The prime focus of the presented research is to investigate the toxicity caused by morphologically different MgO nanostructures obtained by annealing at various annealing temperatures.
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PMC9429973
None did prophylactic antiviral for CMV reactivation.
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PMC10965315
In addition, we evaluated the mRNA expression of MMP‐2 and MMP‐9, in order to further evaluate the antitumor activity of harmaline.
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PMC10454535
The RPMI-1640 medium for RPMI 8226 and HS-5 cells was supplemented with 10% FBS and 1% penicillin-streptomycin.
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PMC7582629
On the other hand, TEM imaging offers high-resolution images down to the nanoscale, but it is a time-consuming and destructive technique.
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PMC6114978
No genomic deletions of the Hippo kinases were identified by FISH in the sarcoma cell lines, with the exception of the RD cell line.
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PMC11612508
In accordance, Hc =|Hc1-Hc2|/2 defines coercivity.
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PMC11684269
Given the heterogeneity of partial renal cells, lactate is an indispensable factor in exploring the pathogenic mechanisms of T cell metabolism in the kidney.
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PMC9429973
3.
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PMC9429973
Methods: Group of patient without combined NS group received nutritional support using parenteral nutrition in case of a decrease in the level of total protein or albumin, which was assessed by a biochemical blood test.
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