OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC10887351	β3-ARs’ activation produced vasorelaxation, but the signaling was different in various cell types.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "β3-ARs", "’", "activation", "produced", "vasorelaxation", ",", ...
PMC11628309	While the BE (2)-M17 is commercially available, a review of the 107 publications retrieved from the PubMed search reveals that only 50.5% of the studies declared obtaining the cells from a formal cell bank (Figure 3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11740207	These ECCs arise from PGCs, which typically develop into gametes like sperm or eggs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "ECCs", "arise", "from", "PGCs", ",", "which", ...
PMC11723947	In contrast, HP1γ represses the TCR-induced expression of PD-1, LAG-3 and other immune checkpoints in differentiating Th cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "contrast", ",", ...
PMC10094992	The neutrophils were washed, pelleted, and resuspended in RPMI-1640 supplemented with 100 IU/mL penicillin, 0.1 mg/mL streptomycin and 0.25 µg/mL amphotericin B. The percentage of neutrophils was evaluated by cytofluorimetric analysis using anti CD14 (monocytes), CD3 (T lymphocytes), and CD66b (neutrophils) antibodies and was considered satisfactory when CD66b > 90%.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10165258	This enabled us to obtain IC50 values for both etoposide and cisplatin alone.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "enabled", "us", "to", "obtain", "IC50", "values", "for", "bot...
PMC11577421	FITC-labeled heparin and totally N,O-desulfated heparin were prepared as described in the Supporting Information.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "FITC-labeled", "heparin", "and", "totally", "N", ",", ...
PMC11806182	D Scatter plot of effects of cis-eQTL SNPs on AURKA expression and UCEC occurence.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "D", "Scatter", "plot", "of", "effects", "of", "cis-eQTL", "SNPs"...
PMC9596868	To study the anti-proliferative effects of quercetin and MST-312, PA-1, A2780 and HCT116 cells were seeded at a density of 8×103 cells/well,1×103 cells/well, 1×103 cells/well respectively in 6-well culture plates.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10988808	Box plots evaluating CCDC25 expression among different groups of tumor grade D, stage E and metastasis F of ccRCC patients based on clinical parameters of TCGA database.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7090062	c Flow cytometric analysis was employed to determine the effect of miR-30a on the apoptosis rates in GIST cells. *	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "c", "Flow", "cytometric", ...
PMC9776316	While the role of HR in platinum resistance is well studied, how NHEJ machinery affects platinum resistance in ovarian cancer remains largely unexplored.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11566417	A loss of telomeres leads to the cessation in replicative processes, limiting a cell’s ability to divide .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "loss", "of", "telomeres", ...
PMC11763111	The control group contained NK and CCRF-CEM cells in a 1:4 ratio.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "control", "group", "contained", "NK", "and", "CCRF-CEM", "cells", ...
PMC11092418	Combination Index < 0.9 = synergistic effect, 0.9 - 1.1 = additive effect, > 1.1 = antagonistic.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Combination", "Index", "<", "0.9"...
PMC8041314	A higher threshold would have led to a larger number of triple ABCB1, ABCC1, and ABCG2 inhibitors, but this would have led to the inclusion of rather inactive compounds.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11106977	As an important and dynamic post-translational modification in mammalian cells, O-GlcNAcylation plays a crucial role in the differentiation of cell lineages, such as bone marrow mesenchymal stromal cells (BMSCs), neural stem cells (NSCs) , and hematopoietic stem cells (HSCs) .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11481779	Fig. 5Loops called on example regions - Chr8:29 100 000–31 100 000 and chr8:123 380 000-125 380 000 - on the real and predicted values Loops called on example regions - Chr8:29 100 000–31 100 000 and chr8:123 380 000-125 380 000 - on the real and predicted values To see the behaviour of the model in the case of the mutations, we have simulated the event of transduplication of a region resembling a small TAD.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC3122064	After exposure of cells to 8 μM cisplatin, p53 became more nuclear localised, while MDM2 was observed in both the nucleus and cytoplasm of cisplatin-sensitive Tera (Figure 1a) and 833KE (data not shown) cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11267830	Through cross-analysis of RNA-seq and quantitative proteomics data, we found that the drug induced widespread RNA alternative splicing and downregulated the expression of related proteins, among which THOC1 and several other genes may be key factors involved in the antitumor effects of indisulam.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11267830	Additionally, previous research has shown that indisulam is a viable and safe therapeutic option for the treatment of AML .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additionally", ",", "previou...
PMC11775197	The first evidence linking PPARβ/δ to cancer was found in CRC .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "first", "evidence", "linking", "PPARβ/δ", "to", "cancer", "was", "found", "in"...
PMC9429973	Emerging evidence suggest myeloblasts could evolve multiple machineries to evade immune patrol and hinder immunotherapies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Emerging", "evidence", "suggest", "myeloblasts", "could", "evolve...
PMC3931643	a. Luciferase reporter assays in VAL and OCI-LY7 cells expressing 4EBP1.	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O" ], "tokens": [ "a.", "Luciferase", "reporter", "assays", "in", "VAL", "and", "OCI-LY7", "...
PMC11803918	To explore the antitumor effect of hybrid exosomes in vivo, the A375 xenograft tumor-bearing nude mice model was established.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "explore", "th...
PMC10538569	These data provide further support that recombinant GPI-anchored proteins can be transferred from transduced T cells to untransduced iDCs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "data", "provide", "furth...
PMC11694066	B–E, Dose–response survival curves of JN1 or R cells exposed to PARPi talazoparib (B and C) or ATRi M4344 (D and E) for 7 days in the presence or absence of siRNA-mediated silencing of EWS–WT1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10813895	The interplay between hormonal dynamics, particularly elevated progesterone levels in BRCA1 mutation carriers, the RANK/RANKL signaling pathway, and ELF5 may provide a crucial mechanistic link to the increased breast cancer risk observed in these individuals.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11469524	Systematic perturbation data for BL-41 cells generated alike the procedure described in Fig 1A (mean, n = 3). (	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Systemati...
PMC11747467	Of note, consistent with previous studies (17), we found that many patients exhibit a mixture type of luminal and basal characteristics, suggesting that most MIBC patients could benefit from a combination approach (17).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11549612	The significant hypomethylation of BOLA1, BOLA2, and BOLA3 promoters in clinical and TCGA KIRC samples compared to normal samples suggests an epigenetic alteration that may influence gene expression levels.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11765879	Further, a migration assay was conducted to evaluate the effect of ZSC extract on preventing the migration of ZR-75-1 and SK-BR-3 cells, thus reflecting its anti-metastatic potential.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "O", "B-CellLine", ...
PMC6889484	First, it will be necessary to demonstrate that a sufficiently high proportion of primary CD4+ T cells, the target of HIV-1 infection, can be engineered to express A3G-D128K to effectively inhibit HIV-1 replication and spread.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11531735	Furthermore, our study extends its focus to the tumor inhibitory and cytotoxic potential of ER121 in comparison to the widely used drug Herceptin, targeting HER2-positive breast cancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Methods: We registered a clinical trial, which is CLAG plus liposomal adriamycin (CLAG+PLD) regimen for re-induction of r/r AML (ChiCTR1800017569), to observe the response, overall survival (OS) and disease free suivival (DFS) of the patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11194678	Representative EMSA assay image of MTOR 5′UTR RNA (20 ng) incubated with increasing amounts of STAU1 WT or 5KE mutant in 500 mM NaCl. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11731161	Collectively, these findings suggest that targeting USP7 could represent a promising therapeutic approach for enhancing the therapeutic efficacy of SEL in MM.Fig.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Collect...
PMC11279397	Apigenin, a flavonoid with low toxicity , exhibits diverse beneficial biological activities including anti-tumor , antioxidant , anti-inflammatory , and antiviral effects .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Apigeni...
PMC9812014	HSV-2 infections, on the other hand, can cause minor genital sores while significantly increasing the chance of contracting and transferring (HIV) and other opportunistic infections .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10994876	Notably, the OE-YAP5SA group consistently demonstrated a significantly higher VCD compared to both the Mock and NT control groups at all time points, except at 24 h (p > 0.05) (Fig. 4a).Fig.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11755519	It has been shown that lncRNA-UCA1 can promote migration and invasion of bladder cancer cells and EMT.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "has", "been", "shown", "that", "lncRN...
PMC11753949	The ER, which typically consists of tubules in dendrites, must expand into sheets.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "ER", ",", "which", "typically", "consists", "of", ...
PMC10237474	Expression titer and (B-C) purification yield for proteins 5 to 10 expressed in CHO-K1 stable pools (blue bars), HEK293S GnTI stable pools (red bars) and Expi293F GnTI stable pools (green bars).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11725127	The catalytic core of USP2, from Asn259 to Met605, was inserted into the pET28a vector.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "catalytic", "core", "of", "USP2", ",...
PMC10530622	Kidney stones were associated with increased cardiovascular risk including coronary heart disease and stroke in a meta-analysis performed in 2014 .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Kidney", "stones", "were", ...
PMC11371627	Results: A novel hemizygous frameshift deletion in the XK gene resulting in premature termination of the amino acid chain was identified in a 46-year old male presenting with decrease in physical performance and persisting fatigue after COVID-19 infection.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9516447	Table S1) were transfected with scramble control siRNA (siCtrl) or siRNA targeting GRP78 (si78).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Table", "S1", ")", "were", ...
PMC11419566	When the cellular FLICE (FADD-like IL-1beta-converting enzyme)-inhibitory protein is recruited at the death-inducing signal complex, caspase is triggered.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "When", "the", "cellular", ...
PMC11768927	Finally, Wollmann et al. explored a novel chimeric virus, VSV-LASV-GPC, which incorporates the glycoprotein precursor from the Lassa virus.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Finally", ",...
PMC11552389	Based on the formula volume (mm) = [length (mm) x width (mm)] / 2, a growth curve for the tumor was generated. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11740207	Studies have shown that these cells undergo ADs, leading to gamete differentiation (Surani et al., 2007; Perrett et al., 2008; Gkountela et al., 2013; Tang et al., 2016).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10440586	The P value was calculated by T-test. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "P", "value", "was", "calculated", "by", "T-test", ".", "(" ] } ]
PMC10565698	A and B. TCF12 mRNA and protein expression in response to TCF12 overexpression in HCCLM3 and BEL-7407 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O" ], "tokens": [ "A", "and", "B.", "TCF12", ...
PMC10631132	Mononuclear cells with some degree of Cathepsin K expression can be seen throughout all groups (empty arrows in A, D, E, H).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8875242	The hPCIS-based model was previously also found to be less sensitive than the Caco-2 system when measuring the inhibitory potency of maraviroc and ledipasvir .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11775197	This will facilitate the identification of efficacious targets for the prevention and treatment of cancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "will", "facilitate", "the", "identification", "of", ...
PMC11687167	④ JAK/STAT signaling pathway.	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "④", "JAK/STAT", "signaling", "pathway", "." ] } ]
PMC11700247	Using CD3 T cells from mice with rejected CT26 tumors after combined RT and CART-19 therapy, we cocultured them with irradiated A20 cells and CART-19 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "...
PMC11394112	The U2932 and VAL DLBCL cell lines were maintained in RPMI 1640 medium supplemented with 15% fetal bovine serum (FBS), 1× penicillin/streptomycin, and 1× Glutmax (Gibco, Life Technologies, Carlsbad, CA, USA) at 37 °C in an atmosphere of 5% CO2.	[ { "tags": [ "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC9275501	Mechanism of natural active ingredients reversing MDR of chemotherapy drugs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mechanism", "of", "natural", "active", "ingredients", "reversing", "MDR", "of", "chemotherapy", ...
PMC9509578	Several nonionic surfactants (Tween 80, vitamin E/TPGS, Brij 35, Pluronic, PEG and PEO, etc.)	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Several", "nonionic", ...
PMC11597291	In the FTIR spectra of the nCGO-PEG particles (Figure 1A, Table 1), all the characteristic peaks of nCGO were observed, including the broad band around 3400 cm attributed to the stretching vibrations of -OH groups, the peak at 1630 cm ascribed to the stretching vibrations of -C=O, the peak at 1386 cm denoting the deformation vibrations of the C-OH groups, and the band at 1061 cm ascribed to the stretching vibrations of the C-O-C. Moreover, the main peaks of PEG polymers were recognized at 2883 cm attributed to the stretching vibration of methylene (-CH2-) groups, and the peak at 1100 cm was ascribed to the stretching vibrations of C-O-C groups.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11607321	First, following a late integration approach, we trained a separate encoder for each dataset to derive latent embeddings specific to each omic layer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC10965315	First, we investigated the antitumor activities of harmaline in ovarian cell line A2780 which is characterized by its ability to invade surrounding tissues as a key feature of cancer metastasis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9268183	The International Agency for Research on Cancer estimates an incidence of 30 million people and more than 16 million deaths directly linked to this illness by 2040 .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11795610	Keratinocyte medium-defined (KM-d) medium was purchased from ScienCell (Carlsbad, California, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Keratinocyte", "medium-defined", "(", "KM-d", ")"...
PMC8557138	The 3D spatial arrangement of organoid is due to its ability to self-organize by cell sorting and in a spatially confined lineage commitment (Takebe et al. 2017).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11638255	Abbreviations: IP intraperitoneal, p.o.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Abbreviations", ":", "IP", "intraperitoneal", ",", "p.o", "." ] } ]
PMC11155445	Almost all compounds showed inhibition activity at a concentration of 100 mg L. Amongst the series compounds (157b and 157f) were found most potent inhibitors with % inhibition of 36.17% and 37.08%, respectively (Fig. 84).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11568601	Data are denoted as the mean ± SD (n = 3). *	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "are", "denoted", "as", "the", "mean", "±", "SD", "...
PMC8916024	Gut microbes have been proved to play an important role in nutrient absorption, physiological metabolism and immune defense, and are essential factors for maintaining the health of aquatic animals (Mitev & Taleski, 2019; Yadav & Jha, 2019).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10870498	The cells were seeded into a 96-well plate at the density of 1 × 10 cells/well.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cells", "were", "seeded", "into", "a", "9...
PMC10631132	In addition to image acquisition using the phase-contrast mode, images for resorption area quantification were taken using the yellow channel in fluorescence mode in order to facilitate differentiation between resorbed and unresorbed areas in ImageJ. RNA extraction and isolation throughout the differentiation process for both iPSC lines using either the EB or the MB method was performed using a RNeasy kit (Qiagen, Hilden, Germany) according to the manufacturer’s protocol.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11713679	The cell viability results indicate a substantial impact of bilobalide in mitigating the amylopathic changes induced by the amyloid beta insult.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cell", "vi...
PMC9429973	A. Sehgal, D. Hoda, P. A. Riedell, N. Ghosh, M. Hamadani, G. C. Hildebrandt, J. E. Godwin, P. Reagan, N. Wagner-Johnston, J. Essell, R. Nath, S. R. Solomon, R. Champion, E. Licitra, S. Fanning, N. Gupta, R. Dubowy, A. D’Andrea, L. Wang, L. I. Gordon University of Pittsburgh Medical Center, Hillman Cancer Center, Pittsburgh; Intermountain Healthcare, Loveland Clinic for Blood Cancer Therapy, Salt Lake City; University of Chicago Comprehensive Cancer Center, Chicago; Levine Cancer Institute, Atrium Health, Charlotte; BMT & Cellular Therapy Program, Medical College of Wisconsin, Milwaukee; Markey Cancer Center, University of Kentucky, Lexington; Providence Cancer Center, Earle A. Chiles Research Institute, Portland; University of Rochester Medical Center, Rochester; Johns Hopkins Hospital, Baltimore; Oncology Hematology Care, Cincinnati; Banner MD Anderson Cancer Center, Gilbert; Northside Hospital Cancer Institute, Atlanta; Norton Cancer Institute, Louisville; Astera Cancer Care, East Brunswick; Prisma Health, Greenville; Stanford Cancer Genetics Clinic, Palo Alto; Bristol Myers Squibb, Seattle, United States of America; Celgene, a Bristol-Myers Squibb Company, Boudry, Switzerland; Northwestern University, Feinberg School of Medicine, Robert H. Lurie Comprehensive Cancer Center, Chicago, United States of America Background: Patients with relapsed or refractory (R/R) LBCL after first-line treatment who are unable to undergo high-dose chemotherapy (HDCT) and hematopoietic stem cell transplantation (HSCT) have poor outcomes and limited treatment options.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11637284	S3 Fig shows a plot depicting the Shannon’s entropy, a measure for the divergence of each position, of a multiple sequence alignment of TAC60 and p166 orthologues from a phylogenetically broad and balanced selection of 12 and 11 Kinetoplastid species, respectively. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11740907	The cells were then subjected to varying doses of P5W30 and P5W30-BW-SLNs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cells", "were", "then", "subjected", "to", "varying", "doses", "of", ...
PMC11775197	Developing new PPAR agonists or antagonists and exploring their potential role in the clinical setting are necessary.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Developing", "new", "PPAR", "agonists", "or", ...
PMC9429973	Yet, there are no reports on the prevalence of thromboembolism in CDA-I patients, with only one case of pulmonary embolism reported in an adult patient Aims: This study sought to evaluate prevalence of thromboembolic events in a group of CDA-I patients, and try to ascertain if this group of patients is at an increased risk of thromboembolism requiring a special follow-up.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11697703	This is likely due to intrinsic differences between the experimental systems used.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "is", "likely", "due", "to", "intrinsic", "differences", "between", "the"...
PMC7039683	Lateral view, anterior to the right, of an embryo at 48 hpf injected at the one cell stage with the PPL-8.3kb:gfp reporter construct. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11696576	These agents were shown to induce mitochondrial ROS-dependent cell death and were reported to synergize based on the ability of venetoclax to suppress the Nrf2-dependent antioxidant response.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6889484	Normalized virus from day 28, round 1, 20% CEMSS:80% CEMSS/D128K cells (low and medium, indicated by blue and red stars, as also shown in the lower panel of F) was used to infect 100% CEMSS/D128K or 100% CEMSS cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11361748	TAR may serve the purpose of transiently protecting skin against additional stress exposures during a period of enhanced keratinocyte vulnerability.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "TAR", "may", "serve", ...
PMC11753435	After an additional three washes with 1× PBST, 100 μl of 3,3′-5,5′-tetramethylbenzidine substrate (1-Step Ultra TMB-ELISA; Thermo Fisher Scientific, 34029) was added to each well, and the plates were incubated at RT in darkness.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9516401	The volume of the mixture was adjusted to 2 ml with deionized water.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "volume", "of", "the", "mixture", "was", "adjusted", "to", "2",...
PMC10777969	The Molinspiration Galaxy3D structures of FCP23 and FCP26, (Figure 3) as generated below, clearly show the differences in the molecular properties.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC5035325	Scale bars = 100 µm. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bars", "=", "100", "µm", ".", "(" ] } ]
PMC10936243	It doesn’t cost much.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "does", "n’t", "cost", "much", "." ] } ]
PMC11707577	Unbound agents were removed by washing thrice with PBS and cells were detached using trypsin 1x.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Unbound", "agents", "were", "removed", "by", "washing"...
PMC11107915	Additionally, for this evaluation, all MCQs on multiple cases available in the test series have been included.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additionally", ",", "for", "this"...
PMC9429973	Statistical analysis was performed with t-test and ANOVA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Statistical", "analysis", "was", "performed", "with", "t-test", "and", "ANOVA", "." ] } ]
PMC9874064	Among them, IC50 of NP-Pt-USP1i was 16.4 μM. However, the IC50 of NP-Pt is > 40 μM (Fig. 3B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11638288	Therefore, the use of HA-deficient VV variants in oncolytic therapy for poxvirus is a promising treatment strategy .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "the", "use", "of", ...
PMC11644761	In conclusion, our findings contribute to the growing body of knowledge on pterostilbene, highlighting its ability to regulate the cell division cycle and induce beneficial changes in DNA methylation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7452526	This small size has confirmed the effective role of AEECL as capping agent.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "small", "size", "has", "confirmed", "the", "effective", "role", ...
PMC11701801	The cells were then reseeded again and treated for 4 days with CP-C27, and IC50 values were calculated based on cell viability.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC7840816	Previous studies reported that EMT occurs during the progression of epithelial tumors to increase the motility and invasiveness of cancer cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Previous", "studies", ...
PMC11711345	Furthermore, sodium cuminate has demonstrated to be a preferable drug candidate for controlled volume intermittent infusions as delivery strategy because of being less toxic, of low BBB permeability, susceptible to Pgp efflux from the CNS, and its acid form showing similar activity to p-cymene against six of nine promising HCCLs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11365427	The BM samples were centrifuged and separated into BM supernatant and BM cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "BM", "samples", "were", "centrifuged", "and", "separated", "into", ...

PMC10887351

β3-ARs’ activation produced vasorelaxation, but the signaling was different in various cell types.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "β3-ARs", "’", "activation", "produced", "vasorelaxation", ",", ...

PMC11628309

While the BE (2)-M17 is commercially available, a review of the 107 publications retrieved from the PubMed search reveals that only 50.5% of the studies declared obtaining the cells from a formal cell bank (Figure 3).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11740207

These ECCs arise from PGCs, which typically develop into gametes like sperm or eggs.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "ECCs", "arise", "from", "PGCs", ",", "which", ...

PMC11723947

In contrast, HP1γ represses the TCR-induced expression of PD-1, LAG-3 and other immune checkpoints in differentiating Th cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "contrast", ",", ...

PMC10094992

The neutrophils were washed, pelleted, and resuspended in RPMI-1640 supplemented with 100 IU/mL penicillin, 0.1 mg/mL streptomycin and 0.25 µg/mL amphotericin B. The percentage of neutrophils was evaluated by cytofluorimetric analysis using anti CD14 (monocytes), CD3 (T lymphocytes), and CD66b (neutrophils) antibodies and was considered satisfactory when CD66b > 90%.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10165258

This enabled us to obtain IC50 values for both etoposide and cisplatin alone.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "enabled", "us", "to", "obtain", "IC50", "values", "for", "bot...

PMC11577421

FITC-labeled heparin and totally N,O-desulfated heparin were prepared as described in the Supporting Information.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "FITC-labeled", "heparin", "and", "totally", "N", ",", ...

PMC11806182

D Scatter plot of effects of cis-eQTL SNPs on AURKA expression and UCEC occurence.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "D", "Scatter", "plot", "of", "effects", "of", "cis-eQTL", "SNPs"...

PMC9596868

To study the anti-proliferative effects of quercetin and MST-312, PA-1, A2780 and HCT116 cells were seeded at a density of 8×103 cells/well,1×103 cells/well, 1×103 cells/well respectively in 6-well culture plates.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10988808

Box plots evaluating CCDC25 expression among different groups of tumor grade D, stage E and metastasis F of ccRCC patients based on clinical parameters of TCGA database.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC7090062

c Flow cytometric analysis was employed to determine the effect of miR-30a on the apoptosis rates in GIST cells. *

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PMC9776316

While the role of HR in platinum resistance is well studied, how NHEJ machinery affects platinum resistance in ovarian cancer remains largely unexplored.

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PMC11566417

A loss of telomeres leads to the cessation in replicative processes, limiting a cell’s ability to divide .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "loss", "of", "telomeres", ...

PMC11763111

The control group contained NK and CCRF-CEM cells in a 1:4 ratio.

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PMC11092418

Combination Index < 0.9 = synergistic effect, 0.9 - 1.1 = additive effect, > 1.1 = antagonistic.

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PMC8041314

A higher threshold would have led to a larger number of triple ABCB1, ABCC1, and ABCG2 inhibitors, but this would have led to the inclusion of rather inactive compounds.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11106977

As an important and dynamic post-translational modification in mammalian cells, O-GlcNAcylation plays a crucial role in the differentiation of cell lineages, such as bone marrow mesenchymal stromal cells (BMSCs), neural stem cells (NSCs) , and hematopoietic stem cells (HSCs) .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11481779

Fig. 5Loops called on example regions - Chr8:29 100 000–31 100 000 and chr8:123 380 000-125 380 000 - on the real and predicted values Loops called on example regions - Chr8:29 100 000–31 100 000 and chr8:123 380 000-125 380 000 - on the real and predicted values To see the behaviour of the model in the case of the mutations, we have simulated the event of transduplication of a region resembling a small TAD.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC3122064

After exposure of cells to 8 μM cisplatin, p53 became more nuclear localised, while MDM2 was observed in both the nucleus and cytoplasm of cisplatin-sensitive Tera (Figure 1a) and 833KE (data not shown) cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11267830

Through cross-analysis of RNA-seq and quantitative proteomics data, we found that the drug induced widespread RNA alternative splicing and downregulated the expression of related proteins, among which THOC1 and several other genes may be key factors involved in the antitumor effects of indisulam.

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PMC11267830

Additionally, previous research has shown that indisulam is a viable and safe therapeutic option for the treatment of AML .

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PMC11775197

The first evidence linking PPARβ/δ to cancer was found in CRC .

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PMC9429973

Emerging evidence suggest myeloblasts could evolve multiple machineries to evade immune patrol and hinder immunotherapies.

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PMC3931643

a. Luciferase reporter assays in VAL and OCI-LY7 cells expressing 4EBP1.

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PMC11803918

To explore the antitumor effect of hybrid exosomes in vivo, the A375 xenograft tumor-bearing nude mice model was established.

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PMC10538569

These data provide further support that recombinant GPI-anchored proteins can be transferred from transduced T cells to untransduced iDCs.

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PMC11694066

B–E, Dose–response survival curves of JN1 or R cells exposed to PARPi talazoparib (B and C) or ATRi M4344 (D and E) for 7 days in the presence or absence of siRNA-mediated silencing of EWS–WT1.

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PMC10813895

The interplay between hormonal dynamics, particularly elevated progesterone levels in BRCA1 mutation carriers, the RANK/RANKL signaling pathway, and ELF5 may provide a crucial mechanistic link to the increased breast cancer risk observed in these individuals.

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PMC11469524

Systematic perturbation data for BL-41 cells generated alike the procedure described in Fig 1A (mean, n = 3). (

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PMC11747467

Of note, consistent with previous studies (17), we found that many patients exhibit a mixture type of luminal and basal characteristics, suggesting that most MIBC patients could benefit from a combination approach (17).

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PMC11549612

The significant hypomethylation of BOLA1, BOLA2, and BOLA3 promoters in clinical and TCGA KIRC samples compared to normal samples suggests an epigenetic alteration that may influence gene expression levels.

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PMC11765879

Further, a migration assay was conducted to evaluate the effect of ZSC extract on preventing the migration of ZR-75-1 and SK-BR-3 cells, thus reflecting its anti-metastatic potential.

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PMC6889484

First, it will be necessary to demonstrate that a sufficiently high proportion of primary CD4+ T cells, the target of HIV-1 infection, can be engineered to express A3G-D128K to effectively inhibit HIV-1 replication and spread.

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PMC11531735

Furthermore, our study extends its focus to the tumor inhibitory and cytotoxic potential of ER121 in comparison to the widely used drug Herceptin, targeting HER2-positive breast cancer.

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PMC9429973

Methods: We registered a clinical trial, which is CLAG plus liposomal adriamycin (CLAG+PLD) regimen for re-induction of r/r AML (ChiCTR1800017569), to observe the response, overall survival (OS) and disease free suivival (DFS) of the patients.

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PMC11194678

Representative EMSA assay image of MTOR 5′UTR RNA (20 ng) incubated with increasing amounts of STAU1 WT or 5KE mutant in 500 mM NaCl. (

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PMC11731161

Collectively, these findings suggest that targeting USP7 could represent a promising therapeutic approach for enhancing the therapeutic efficacy of SEL in MM.Fig.

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PMC11279397

Apigenin, a flavonoid with low toxicity , exhibits diverse beneficial biological activities including anti-tumor , antioxidant , anti-inflammatory , and antiviral effects .

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PMC9812014

HSV-2 infections, on the other hand, can cause minor genital sores while significantly increasing the chance of contracting and transferring (HIV) and other opportunistic infections .

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PMC10994876

Notably, the OE-YAP5SA group consistently demonstrated a significantly higher VCD compared to both the Mock and NT control groups at all time points, except at 24 h (p > 0.05) (Fig. 4a).Fig.

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PMC11755519

It has been shown that lncRNA-UCA1 can promote migration and invasion of bladder cancer cells and EMT.

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PMC11753949

The ER, which typically consists of tubules in dendrites, must expand into sheets.

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PMC10237474

Expression titer and (B-C) purification yield for proteins 5 to 10 expressed in CHO-K1 stable pools (blue bars), HEK293S GnTI stable pools (red bars) and Expi293F GnTI stable pools (green bars).

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PMC11725127

The catalytic core of USP2, from Asn259 to Met605, was inserted into the pET28a vector.

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PMC10530622

Kidney stones were associated with increased cardiovascular risk including coronary heart disease and stroke in a meta-analysis performed in 2014 .

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PMC11371627

Results: A novel hemizygous frameshift deletion in the XK gene resulting in premature termination of the amino acid chain was identified in a 46-year old male presenting with decrease in physical performance and persisting fatigue after COVID-19 infection.

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PMC9516447

Table S1) were transfected with scramble control siRNA (siCtrl) or siRNA targeting GRP78 (si78).

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PMC11419566

When the cellular FLICE (FADD-like IL-1beta-converting enzyme)-inhibitory protein is recruited at the death-inducing signal complex, caspase is triggered.

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PMC11768927

Finally, Wollmann et al. explored a novel chimeric virus, VSV-LASV-GPC, which incorporates the glycoprotein precursor from the Lassa virus.

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PMC11552389

Based on the formula volume (mm) = [length (mm) x width (mm)] / 2, a growth curve for the tumor was generated. (

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PMC11740207

Studies have shown that these cells undergo ADs, leading to gamete differentiation (Surani et al., 2007; Perrett et al., 2008; Gkountela et al., 2013; Tang et al., 2016).

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PMC10440586

The P value was calculated by T-test. (

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PMC10565698

A and B. TCF12 mRNA and protein expression in response to TCF12 overexpression in HCCLM3 and BEL-7407 cells.

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PMC10631132

Mononuclear cells with some degree of Cathepsin K expression can be seen throughout all groups (empty arrows in A, D, E, H).

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PMC8875242

The hPCIS-based model was previously also found to be less sensitive than the Caco-2 system when measuring the inhibitory potency of maraviroc and ledipasvir .

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PMC11775197

This will facilitate the identification of efficacious targets for the prevention and treatment of cancer.

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PMC11687167

④ JAK/STAT signaling pathway.

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PMC11700247

Using CD3 T cells from mice with rejected CT26 tumors after combined RT and CART-19 therapy, we cocultured them with irradiated A20 cells and CART-19 cells.

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PMC11394112

The U2932 and VAL DLBCL cell lines were maintained in RPMI 1640 medium supplemented with 15% fetal bovine serum (FBS), 1× penicillin/streptomycin, and 1× Glutmax (Gibco, Life Technologies, Carlsbad, CA, USA) at 37 °C in an atmosphere of 5% CO2.

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PMC9275501

Mechanism of natural active ingredients reversing MDR of chemotherapy drugs.

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PMC9509578

Several nonionic surfactants (Tween 80, vitamin E/TPGS, Brij 35, Pluronic, PEG and PEO, etc.)

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PMC11597291

In the FTIR spectra of the nCGO-PEG particles (Figure 1A, Table 1), all the characteristic peaks of nCGO were observed, including the broad band around 3400 cm attributed to the stretching vibrations of -OH groups, the peak at 1630 cm ascribed to the stretching vibrations of -C=O, the peak at 1386 cm denoting the deformation vibrations of the C-OH groups, and the band at 1061 cm ascribed to the stretching vibrations of the C-O-C. Moreover, the main peaks of PEG polymers were recognized at 2883 cm attributed to the stretching vibration of methylene (-CH2-) groups, and the peak at 1100 cm was ascribed to the stretching vibrations of C-O-C groups.

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PMC11607321

First, following a late integration approach, we trained a separate encoder for each dataset to derive latent embeddings specific to each omic layer.

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PMC10965315

First, we investigated the antitumor activities of harmaline in ovarian cell line A2780 which is characterized by its ability to invade surrounding tissues as a key feature of cancer metastasis.

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PMC9268183

The International Agency for Research on Cancer estimates an incidence of 30 million people and more than 16 million deaths directly linked to this illness by 2040 .

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PMC11795610

Keratinocyte medium-defined (KM-d) medium was purchased from ScienCell (Carlsbad, California, USA).

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PMC8557138

The 3D spatial arrangement of organoid is due to its ability to self-organize by cell sorting and in a spatially confined lineage commitment (Takebe et al. 2017).

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PMC11638255

Abbreviations: IP intraperitoneal, p.o.

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PMC11155445

Almost all compounds showed inhibition activity at a concentration of 100 mg L. Amongst the series compounds (157b and 157f) were found most potent inhibitors with % inhibition of 36.17% and 37.08%, respectively (Fig. 84).

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PMC11568601

Data are denoted as the mean ± SD (n = 3). *

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PMC8916024

Gut microbes have been proved to play an important role in nutrient absorption, physiological metabolism and immune defense, and are essential factors for maintaining the health of aquatic animals (Mitev & Taleski, 2019; Yadav & Jha, 2019).

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PMC10870498

The cells were seeded into a 96-well plate at the density of 1 × 10 cells/well.

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PMC10631132

In addition to image acquisition using the phase-contrast mode, images for resorption area quantification were taken using the yellow channel in fluorescence mode in order to facilitate differentiation between resorbed and unresorbed areas in ImageJ. RNA extraction and isolation throughout the differentiation process for both iPSC lines using either the EB or the MB method was performed using a RNeasy kit (Qiagen, Hilden, Germany) according to the manufacturer’s protocol.

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PMC11713679

The cell viability results indicate a substantial impact of bilobalide in mitigating the amylopathic changes induced by the amyloid beta insult.

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PMC9429973

A. Sehgal, D. Hoda, P. A. Riedell, N. Ghosh, M. Hamadani, G. C. Hildebrandt, J. E. Godwin, P. Reagan, N. Wagner-Johnston, J. Essell, R. Nath, S. R. Solomon, R. Champion, E. Licitra, S. Fanning, N. Gupta, R. Dubowy, A. D’Andrea, L. Wang, L. I. Gordon University of Pittsburgh Medical Center, Hillman Cancer Center, Pittsburgh; Intermountain Healthcare, Loveland Clinic for Blood Cancer Therapy, Salt Lake City; University of Chicago Comprehensive Cancer Center, Chicago; Levine Cancer Institute, Atrium Health, Charlotte; BMT & Cellular Therapy Program, Medical College of Wisconsin, Milwaukee; Markey Cancer Center, University of Kentucky, Lexington; Providence Cancer Center, Earle A. Chiles Research Institute, Portland; University of Rochester Medical Center, Rochester; Johns Hopkins Hospital, Baltimore; Oncology Hematology Care, Cincinnati; Banner MD Anderson Cancer Center, Gilbert; Northside Hospital Cancer Institute, Atlanta; Norton Cancer Institute, Louisville; Astera Cancer Care, East Brunswick; Prisma Health, Greenville; Stanford Cancer Genetics Clinic, Palo Alto; Bristol Myers Squibb, Seattle, United States of America; Celgene, a Bristol-Myers Squibb Company, Boudry, Switzerland; Northwestern University, Feinberg School of Medicine, Robert H. Lurie Comprehensive Cancer Center, Chicago, United States of America Background: Patients with relapsed or refractory (R/R) LBCL after first-line treatment who are unable to undergo high-dose chemotherapy (HDCT) and hematopoietic stem cell transplantation (HSCT) have poor outcomes and limited treatment options.

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PMC11637284

S3 Fig shows a plot depicting the Shannon’s entropy, a measure for the divergence of each position, of a multiple sequence alignment of TAC60 and p166 orthologues from a phylogenetically broad and balanced selection of 12 and 11 Kinetoplastid species, respectively. (

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PMC11740907

The cells were then subjected to varying doses of P5W30 and P5W30-BW-SLNs.

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PMC11775197

Developing new PPAR agonists or antagonists and exploring their potential role in the clinical setting are necessary.

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PMC9429973

Yet, there are no reports on the prevalence of thromboembolism in CDA-I patients, with only one case of pulmonary embolism reported in an adult patient Aims: This study sought to evaluate prevalence of thromboembolic events in a group of CDA-I patients, and try to ascertain if this group of patients is at an increased risk of thromboembolism requiring a special follow-up.

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PMC11697703

This is likely due to intrinsic differences between the experimental systems used.

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PMC7039683

Lateral view, anterior to the right, of an embryo at 48 hpf injected at the one cell stage with the PPL-8.3kb:gfp reporter construct. (

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PMC11696576

These agents were shown to induce mitochondrial ROS-dependent cell death and were reported to synergize based on the ability of venetoclax to suppress the Nrf2-dependent antioxidant response.

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PMC6889484

Normalized virus from day 28, round 1, 20% CEMSS:80% CEMSS/D128K cells (low and medium, indicated by blue and red stars, as also shown in the lower panel of F) was used to infect 100% CEMSS/D128K or 100% CEMSS cells.

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PMC11361748

TAR may serve the purpose of transiently protecting skin against additional stress exposures during a period of enhanced keratinocyte vulnerability.

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PMC11753435

After an additional three washes with 1× PBST, 100 μl of 3,3′-5,5′-tetramethylbenzidine substrate (1-Step Ultra TMB-ELISA; Thermo Fisher Scientific, 34029) was added to each well, and the plates were incubated at RT in darkness.

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PMC9516401

The volume of the mixture was adjusted to 2 ml with deionized water.

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PMC10777969

The Molinspiration Galaxy3D structures of FCP23 and FCP26, (Figure 3) as generated below, clearly show the differences in the molecular properties.

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PMC5035325

Scale bars = 100 µm. (

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PMC10936243

It doesn’t cost much.

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PMC11707577

Unbound agents were removed by washing thrice with PBS and cells were detached using trypsin 1x.

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PMC11107915

Additionally, for this evaluation, all MCQs on multiple cases available in the test series have been included.

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PMC9429973

Statistical analysis was performed with t-test and ANOVA.

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PMC9874064

Among them, IC50 of NP-Pt-USP1i was 16.4 μM. However, the IC50 of NP-Pt is > 40 μM (Fig. 3B).

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PMC11638288

Therefore, the use of HA-deficient VV variants in oncolytic therapy for poxvirus is a promising treatment strategy .

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PMC11644761

In conclusion, our findings contribute to the growing body of knowledge on pterostilbene, highlighting its ability to regulate the cell division cycle and induce beneficial changes in DNA methylation.

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PMC7452526

This small size has confirmed the effective role of AEECL as capping agent.

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PMC11701801

The cells were then reseeded again and treated for 4 days with CP-C27, and IC50 values were calculated based on cell viability.

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PMC7840816

Previous studies reported that EMT occurs during the progression of epithelial tumors to increase the motility and invasiveness of cancer cells.

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PMC11711345

Furthermore, sodium cuminate has demonstrated to be a preferable drug candidate for controlled volume intermittent infusions as delivery strategy because of being less toxic, of low BBB permeability, susceptible to Pgp efflux from the CNS, and its acid form showing similar activity to p-cymene against six of nine promising HCCLs.

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PMC11365427

The BM samples were centrifuged and separated into BM supernatant and BM cells.

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