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OTAR3088
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BioData-CellLine_annotated

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PMC11371627
For our patient, the onset of initially unspecific symptoms such as fatigue, decrease of physical performance and perception of unspecific muscle weakness was subjectively referred to COVID-19 disease.
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PMC7081114
First, data on the differential expression of KIF21B in patients with HCC from The Cancer Genome Atlas database was analyzed.
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PMC9429973
PBMC were separated from the whole blood by density gradient centrifugation and the CD4+ T-cells were separated using negative selection on magnetic beads.
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PMC11548041
PLD02 is 29 nucleotides and has a stem-loop structure with single-stranded segments at both termini (Figure 1D).
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PMC10538569
The trans-inhibitory activity requires cell-cell contact with GPI-scfv X5 transduced CD4 T cells.
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PMC10809689
Then 500 µl of methanol was added to each of the dried samples and were dissolved well.
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PMC9504875
To date, the OTU domain is the only known putative antagonist of host IFN system in nairoviruses.
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PMC9429973
Median age was 67 (range 30–84) years.
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PMC9429973
Additionally, we propose a novel three-tiered survival model based on response, ASXL1 mutation and karyotype.
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PMC11680982
This suggests that HER2 is an important mediator in the transition of tumor cells from G1 to the S phase and represents an upstream pathway affecting the Cyclin D1-CDK4/6 pathway in HR/HER2-low breast cancer.
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PMC9164404
For tumor inhibition study, Abplatin was i.v.
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PMC11733919
Thus, NRF2 is also considered a negative modulator of ferroptosis by GPX4-mediated attenuation of lipid peroxidation.
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PMC3995603
The data are expressed as the mean ± SEM and were analyzed using a one-way ANOVA followed by the Bonferroni multiple comparison test.
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PMC11128598
Cancer stands as a major health issue worldwide; the number of new cancer cases diagnosed in 2020 was 19.3 million, and almost 10.0 million people die every year due to this disease (1).
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PMC11322866
Therefore, we hypothesized that the homeostasis of Lamin B1 protein level is essential for maintaining normal cellular function.
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PMC11730311
K* refers to the lysine residue where the C20DA-γGlu is positioned.
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PMC10728200
but there was no significant difference in overall survival(OS) (Fig. S9).Fig.
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PMC11755624
They have the ability to induce changes in gene expression in a locus-specific manner through recruitment of chromatin modifying factors .
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PMC2193049
Digestion of peptide MAGE-3271–285 with trypsin completely abrogated recognition of the target cells by specific CTL.
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PMC11637284
Images were processed using Fiji software.
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PMC10142392
One of the main goals of nanocarrier-assisted drug administration is to improve the quality of life of patients through effective therapeutic interventions while seeking better management and treatment of high-risk and high-morbidity diseases in a broader perspective.
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PMC11092382
In the future, this protective effect will need to be further validated in various disease models.
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PMC11476004
Kamlesh et al. used the same test to study the frequency of genomic instability in oral squamous cell carcinoma, regarding it as a highly reliable biomarker.
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PMC9611901
Generally, the first step in the evaluation of potential toxic effects of unknown or poorly known mixtures of chemicals is selection of a suitable test model.
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PMC11734514
Visualization of protein expression was normalized with β-actin.
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PMC10094712
This increase in Ca ions in the cytosol leads to the activation of m-calpain which in turn leads to the activation of CAS-4 and the induction of apoptosis.
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PMC11194678
Left: Representative DIC images of the reaction mixtures with STAU1 WT or 5KE mutant after the in vitro translation assay.
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PMC8751435
Meanwhile, amount of shrinking cell and bubbling cells were reduced by CME combining AC‐Dc of 270pM. Effect of Cordyceps militaris extract (CME) on viability and morphology in the present of caspase‐3 inhibitor Ac‐DEVD‐CHO (Ac‐DC). (
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PMC8382973
Under the linear assumption, the standard error of IC50 can be estimated (31).
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PMC11506670
Two cell lines were used in this study, as follows: the NIH3T3 murine embryonic fibroblast cell line (Cat.
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PMC10809689
In the last step, the optical density (OD) of each sample against blank was read at a wavelength of 570 nm with a microplate reader (Hyperion, Germany) .
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PMC11789597
MM1S cells expressing shNC or shCAV1 were treated with bafilomycin A1 (Baf‐A1) at the indicated concentrations for 48 h and the cell viability was measured.
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PMC11747949
Data shown as Means +/− SD, n = 10 per experimental group. (
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PMC11551844
The hexane (JDH), ethyl acetate (JDE), sterols (JC-2) and jaspamide (1) (Fig. 1) were obtained from the marine sponge Jaspis diastra, whereas pure compounds contignasterol (2), ansellone A (3) and motuporamines A (4) (Fig. 1) were obtained from Petrosia contignata, Cadlina luteomarginata, Phorbas sp. and Xestospongia exigua respectively.
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PMC11787651
No additional significant change was observed.
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PMC10878518
Subsequently, primary cultures of normal fibroblasts were established, as reported previously .
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PMC9841531
For this purpose, a PI/Annexin V-FITC apoptosis detection kit (BD Biosciences, Franklin Lakes, NJ) was used following the manufacturer’s instructions.
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PMC11075223
Furthermore, macromolecular triterpenoid-chromone hybrids (341–348) were identified from C. foetida by Nuclear Magnetic Resonance (NMR) and high resolution electrospray ionization mass spectroscopy (HRESI-MS) shown in Fig. S5 .
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PMC9841531
Up to date, only compound 4 reached the clinical drug development stage (NCT01791595, completed 2022); the screening of chemical space as well as the exploration and exploitation of novel molecular–structural compound classes necessitates.
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PMC9031474
It was also shown, that the C9 configuration influences the anticancer activity but contradictory results are currently present .
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PMC11721064
6LNCs facilitate the transdifferentiation of KPCs towards corneal epithelial cells via the STAT3 signaling pathway.
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PMC11699178
The ultimate aim of this study is to extensively investigate the mechanism of GEM in ovarian cancer treatment, particularly its impact on the HIF-1α/VEGFB/FGF2/FGFR1 signaling pathway.
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PMC11206502
Therapeutic strategies for BC may cause unfavorable side effects and complications.
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PMC8623816
The 5′-terminal sequences of both dsRNAs have a high similarity, which might be involved in the replication cycle of the dsRNAs .
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PMC11470381
xh1, yh1): half-centers of front half; (xh2, yh2): half-centers of back half.
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PMC11653168
The ATG5 antibody used in the present study can detect the ATG5-ATG12 conjugate with a molecular weight of ~50 kDa.
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PMC11572213
In addition, P-AMPKα protein expression was increased in TET2-knockdown HL-60 cells in low glutamine-containing medium.
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PMC11704135
Pyrimidine is the parent ring system of numerous substances that are essential to biological functions.
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PMC11453018
Supernatant collected at 48 and 72 h post-infection, mixed with polybrene (10 µg/ml), was used to infect SKES1 cells.
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PMC11519077
A powerful proinflammatory cytokine called IL-1β is essential for the host's defense mechanisms in response to infection and damage.
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PMC11743414
These findings suggest that these genes may be involved in the occurrence and development of AML.Fig.
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PMC11629143
Production of mAb was quantified by ELISA.
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PMC11489351
These results include CA9, CCND1, and the differentiation regulatory protein cluster of differentiation 70 (CD70) (Fig. 2, A and B and Table S2).
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PMC11675244
Overexpressed β-catenin is phosphorylated and marked with ubiquitin for proteasomal digestion by a destruction complex.
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PMC11718031
The average VCC was 8–10 million cells/mL for other basal media tested in our study.
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PMC11628309
SH-SY5Y is a subline of the SK-N-SH cell line which was established in 1970 from a metastatic bone tumor of a 4-year-old female (ATCC- CRL-2266).
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PMC7334607
This relative sensitivity between experimental and control evolutionary replicates is visualized as a negative log2 fold change in Figure 2.
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PMC11574271
The mice in the control group (J82-RON, 5 mice per group) and mice from the J82-NC group, 5 mice per group) were administered with solvents.
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PMC7823217
Moreover, spatial control of matrix properties, ability to integrate perfusable vascular networks, automation and high-throughput testing abilities for determining metabolic, and toxicological properties are imperative features of bioprinted cancer models .
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PMC11078693
Permeabilization quenching buffer for 20 mL fixed cells Note: Permeabilization/quenching buffer was made fresh prior to use.
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PMC9429973
There were 2 early deaths, in the cohort, both in pts > 75 yo with high risk disease due to multi-organ failure and bleeding within 5 days of presentation.
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PMC11502066
There are approximately 800 distinct GPCR genes encoded by the human genome, constituting the largest family of druggable targets .
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PMC9429973
In this small cohort, 49% of patients developed a cellular response despite a severely abrogated humoral immunity.
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PMC9429973
Reasons for switching to BOS: intolerance 65%, resistance 35%.
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PMC9429973
African respondents were 3 times more likely to report lack of information (OR 3.1 CI 1.8-5.3, p<0.0001) and 5 times more likely to report malaria-related barriers than Caucasians (OR 5.1 CI 2.1-12.3, p=0.0002).
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PMC10761218
Indians have been using this herb for therapeutic purposes since time immemorial .
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PMC10582049
Single-cell RNA sequencing and histological assessment showed that aggressive LUADs are characterized by a decreased number of ADH1B CAFs in comparison to indolent tumors.
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PMC6034753
Meq and N-terminal FLAG tagged apoptin expression constructs were transfected into CEFs by Lipofectamine and DF-1 cells by Lipofectamine 2000 reagents respectively (Invitrogen, Karlsruhe, Germany).
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PMC9429973
For the specimen with mutational HbH, the initial b/aR matches that of healthy controls, as the mutations do not eliminate the ability for the gene to produce aberrant mRNA transcripts, and decreased with increasing VCN.
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PMC9429973
Study quality was assessed with a version of the GRADE (Grading of Recommendations, Assessment, Development and Evaluations) framework, adapted to observational studies.
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PMC11046454
Remarkably, in groups treated with either ATP-AptPTK7-CAR-T or AptPTK7-CAR-T, we observed a substantial presence of CD3 T cells deep within the tumor sections (Figure 5D).
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PMC7171147
The mRNA expression of FAO enzymes was increased in ES2 cells co-cultured with scrambled CAFs (Fig. 1B) or supplemented with recombinant COL11A1 protein (Fig. S1D).
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PMC5925824
The combination of LY3300054 and ipilimumab further upregulated T-cell specific genes reflecting a Th1 response (IFNG, IL2, TBX21), T-cell activation (IL2, IFNG, ICOS) and downregulation of myeloid genes (CD68, CD14, HLA-DRA).Fig.
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PMC11095939
Data are presented as means ± SEM.
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PMC11786767
To visualize both proteins and lipids of cultured mammalian cells at a super-resolution scale, we established a modified protocol called TT-ExM (expansion microscopy with trypsin digestion and tyramide signal amplification) that involves application of trypsin and tyramide signal amplification (TSA) technologies.
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PMC10745221
Because arginine methylation on histones can affect gene expression, we wanted to analyze any differences in SDMA and ADMA modifications on histones between each cell line.
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PMC11438317
Although these amino acids are also common between -7 and + 7, they are most noticeable in positions −2 and −3.
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PMC11680982
The mammary fat pad of each mouse was injected with 5 × 10 human ZR-75-1 cells in 150 µL PBS.
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PMC9429973
All patients received at least 1 InO course.
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PMC11216402
We calculated CN differences between the 15 Epi-like GC cell lines and the combined five Mes-like and five Intermediate cell lines, and we plotted the average CN differences for each gene in the two groups, that is, mean(NonEpi CN) − mean(Epi CN).
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PMC6379402
The siRNA mixture was added dropwise to the cells.
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PMC10604092
Values of p < 0.05 were considered statistically significant.
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PMC6803987
The expression of antigen in cell supernatant was detected by ELISA kits.
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PMC9545474
For doing so, we take advantage of the vacant coordination site on the 16‐electron complex 3 to add hydrophilic ligands and to synthesise the 18‐electron adducts.
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PMC10047551
NSCLC patients having developed resistance to anti-PD-1 therapy showed increased PD-L1 methylation and reduced mRNA and protein expression in the recurred tumor tissue .
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PMC10170482
F-actin tension was visualized using the look-up table Physics in the ImageJ software (NIH).
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PMC11451829
The eyes were topically anesthetized with a drop of tetracaine (5 mg/mL, Sophia, Mexico City, Mexico), and a wire lid speculum was inserted to retract the lid for conjunctival exposure.
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PMC11790971
Nonetheless, findings from this study, particularly the significance of correlation features, will inspire the design of more efficient pipelines.
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PMC9429973
Disease- or treatment-related factors did not significantly associate with any of the other comorbidities we studied.
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PMC6642070
As shown in Fig. 5c, the luciferase reporter construct containing three point mutations in p53RRE3 (RRE3-MUT) displayed significant higher activity than the wild type construct (RRE3-WT).
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PMC8873393
Nuclear DNA was counterstained with DAPI.
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PMC11787355
Similarly, in our own cohort, we found higher PTPRZ1 expression levels in AC-like and OPC-like glioblastoma cells (Fig. 1i–k).
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PMC9910796
African swine fever virus (ASFV) causes a devastating hemorrhagic disease in both domestic pigs and Eurasian wild boars, whose control is currently based on culling and strict containment measures due to the absence of widely available vaccine or other therapeutic tools available [1–5].
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PMC10926885
A combination of protease, phosphatase inhibitor and RIPA lysis solution was used to lyse T24 and 5637 cells.
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PMC11476222
While Li et al. were able to identify 165 gangliosides and 100 isomers using this method, this requires not only multiple instruments (GC-MS and LC-MS) but also advanced instrumental expertise to couple mass spectrometry instruments together .
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PMC10812665
For all three compounds, we identified concentrations at which respiration was inhibited, but ATP did not drop.
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PMC11082662
Taken together, these data strongly support the notion that SMPDL3B is upregulated in ovarian cancer.
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PMC7215722
Every 30 min, 200 µl of PBS from the bottom of each well was collected, followed by the addition of new PBS (200 µl) for 2 h. Optic densities were measured at 630 nm, and concentrations of Evans blue were calculated.
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PMC11269933
However, there is currently no relevant report regarding PK phosphorylation-mediated activity regulation in marine animals.
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PMC9429973
The median CR duration was short at 7.3 months.
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