OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC11629192	Protein A immunoadsorption (IA) was initiated, with four sessions every other day, followed by a second IVIG course.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Protein", "A...
PMC9429973	However, more studies are necessary for validating our data.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "more", "studies", "are", "necessary", "for", "validating", "our", "data", ...
PMC9786247	The differences in replication efficiencies that we observed in the present study were minor, even though strains of the MLVA genotype II, on average, replicated significantly better than genotype I strains.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11394227	For disulfide bond folding, HCs and LCs are translocated to the ER; HCs and LCs co-translate the translocations to the ER for disulfide bond folding .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11127909	The results showed that only the truncated form of EFHD1 that retained its N-terminal region interacted with ANT3, suggesting that the N-terminal region is crucial for binding (Fig. 5C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10522430	Furthermore, the study elucidated the underlying mechanism of GACP-induced apoptosis, particularly through the intrinsic pathway.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "the", "study", "elucidated", ...
PMC6461034	Add 1 ml cold IP buffer per 10 mg protein input to the bead pellet and mix by inverting five times.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Add", "1", "ml", ...
PMC11413393	In addition, DDR genes such as FANCM, FANCD2 and BRCA2 are decreased at both the transcriptional and protein level, thus DSBs that result from the presence of unresolved R-loops are not repaired.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10899471	As shown in Figure 4C , luciferase reporter assays confirmed that overexpression of miR-939-3p suppressed the luciferase activity of wild-type (WT) recombinant BATF2 3’ UTR.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7612475	Cells were resuspended in 10 mL Carnoy solution and cells left overnight at 4°C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "resuspended", "in", "10", "mL", ...
PMC10470467	Hence, these results enlighten us that CHMP7 plays a unique role in ES, which is worthy of our in-depth study.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Hence", ",",...
PMC10142392	Generally, structures with high curvature (such as spherical micelles) are formed when Cpp < 1/3, cylindrical micelles are formed when 1/3 ≤ Cpp < 1/2, and low curvature bilayer membranes are formed when 1/2 ≤ Cpp < 1 (Figure 11).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11727638	The medium was replaced every 2–3 days (Figure 1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "medium", "was", "replaced", "every", "2–3", "days", "(", "Figure", "1", ...
PMC10538569	at 6 hours, 1, 2, 3, 6, 9 and 12 days, small portions of cell suspension were harvested and replaced with fresh complete RPMI 1640 medium and human rIL-2 (100 IU/ml).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8557138	Ghosh et al., developed an in vitro melanoma angiogenesis model employing multicellular tumor spheroids arising from differentiated (HBL) or undifferentiated (NA8) melanoma cell lines with the aim to determine the correlation of expression with respect to the differentiation marker of cancer cells along with angiogenesis (Ghosh et al. 2007).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "B-CellLine", "...
PMC10048572	NGS also provides information about subclones of solid tumors and is used to study tumor metastatic patterns.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "NGS", "also", "provides", "information", "about",...
PMC10631132	In view of clinical translation, a fully defined differentiation process without the use of FBS for terminal OC differentiation will be needed .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", ...
PMC11387401	First of all, the interactome was determined in cell lines rather than primary CD4 + T-cells, to meet the large number of cells needed for nRIPseq.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11537649	Direct binding of the indicated molecules was verified by an RNA-binding protein immunoprecipitation assay and a dual luciferase reporter assay.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Direct", "binding", "of", ...
PMC11628309	Many of these models are derived from human cells, bridging the gap between animal studies and clinical trials on patients, thus contributing to the searching and understanding of the mechanisms associated with potential drugs (Slanzi et al., 2020).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11687663	There is very limited research on LC-MS profiling for A. helferiana.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "There", "is", "very", "limited", "research", "on", "LC-MS", "profiling", "for", "A.",...
PMC11045125	Thus, the tumor derived cell lines derived from ΔEBNA2 + Myc lymphomas (except for the LMP1-expressing R3 line) more closely resemble human EBV+ BLs in comparison to the P493-6 cell line.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8316344	TRIB2 has the capacity to reduce global Ub ; however, TRIB2 is upregulated in liver cancer cells .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "TRIB2", "has", "the", "capacity", "to"...
PMC11462673	Collectively, the findings of our research highlight the particular upregulation of the LDB1 gene in T-ALL, and an increased level of LDB1 is linked to a negative outlook, underscoring the significant pathogenic role of LDB1 in T-ALL patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11803149	GSEA was performed using scRNA-seq data obtained in Figure 4 .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "GSEA", "was", "performed", "using", "scRNA-seq", "data", "obtained", "in", "Figure", "4", ...
PMC11799620	This analysis demonstrates that the increment in the extraction time over 10 minutes lowers the phenolic content.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "analysis", "demonstrates", "that", "the",...
PMC11760643	The original study of Buell et al. demonstrated an IC50 of 0.0008 µg/mL for 2′,3′‐(4‐benzoyl)‐benzoyl‐ATP‐induced nucleotide currents into HEK‐P2X7 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "The", "original", "...
PMC9429973	S. Sciabolacci, L. Ruggeri, V. Cardinali, L. Brunetti, S. Tricarico, S. Saldi, F. Marzuttini, M. Griselli, G. Perta, V. Viglione, G. Cimino, A. Osmani, M. Caridi, R. Sembenico, A. Terenzi, T. Zei, R. Iacucci Ostini, M. F. Martelli, B. Falini, A. Velardi, C. Aristei, C. Mecucci, A. Carotti, M. P. Martelli, A. Pierini Division of Hematology and Clinical Immunology; Department of Surgical and Biomedical Science, Perugia General Hospital, Perugia, Italy Background: Patients with newly diagnosed acute myeloid leukemia with myelodysplasia-related changes (MRC-AML) or therapy-related AML (t-AML) have an extremely poor prognosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10589262	The H-score method, which assigns an IHC H-score to each case on a continuous scale of 0–300 based on the percentage of cells at different staining intensities, was used for the interpretation of KIT and ATF6 results.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Median CD8+ >200 (200-1300/μL) was first observed 4 months post BMT in Sib and Haplo and 7 months in MUD.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC10588957	Proteins were separated by SDS-polyacrylamide gel electrophoresis (SDS-PAGE) and transferred to a polyvinylidene fluoride (PVDF) membrane.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Proteins", "were", "separate...
PMC9429973	Annual prevalence analysis of cohort 1 AEs showed reduced prevalence of hemorrhage over time and lower prevalence with ZANU vs IBR at all intervals.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9429973	The nucleotide sequence of CRBN and amino acid sequence were downloaded from NCBI and UniProt respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "nucleotide", "sequence", "of", "CRBN", "and", ...
PMC11583690	BPMO@DTX, MSN@DTX, and pure DTX (same amount as the amount loaded onto the nanomaterials) samples were dispersed via ultrasonication in 10 mL of a release medium containing PBS + 0.1 % (v/v) tween 80 (pH 7.4) and then placed into the diffusion cells and sealed tightly at both ends.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC3675084	BPR0L075 blocks cell cycle at the G2/M phase in paclitaxel-resistant cells while equal concentration of paclitaxel treatment was ineffective.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "BPR0L075", "blocks", "cell", "cyc...
PMC9429973	Non-haematological toxicity was reported in 19 (43%) patients (most commonly fatigue (n=4), insomnia (n=3), bone pain (n=2), back pain (n=2), nausea (n=2), fluid retention (n=2)), with only 2 (4%) patients experiencing grade 3-4 toxicity (fatigue in both cases).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10994876	Subsequently, the cells were suspended again in 500 mL of PBS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Subsequently", ",", "the", "cells", "were", "suspended", "again", "in", "500", ...
PMC11607638	No difference in SKR mRNA expression was found between SK‐injected experimental groups and DEPC water‐injected control (Figure 3D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "No", "difference", "in", ...
PMC6267596	Time-lapse imaging of single viable polyploid cells demonstrated that DIAP cells divide by reductive cell divisions in the absence of drug.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Time-lapse", "imaging",...
PMC11767817	The assay was performed for compounds 2a and 2a-B under normoxic conditions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "assay", "was", "performed", "for", "compounds", "2a", "and", "2a-B", ...
PMC5386478	However, the regulatory mechanisms of TG2 in cell death require additional studies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "the", "regulatory", "mechanisms", "of", "TG2", "in", ...
PMC11754784	Therefore, macrophages that phagocytosed cancer cells will be stained by Far Red and exhibit enhanced fluorescence in Far Red channel.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", ...
PMC11621493	Primary cells were isolated from the epidermis of two-day-old neonatal mice and cultured for four days in the presence of low CaCl2 concentrations (0.06 mM).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11718817	He et al. used three-dimensional tumor cultures seeding human primary monocytes into the spheroid upon formation .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "He", "et", "al.", "used", "three-dimensional", "tumor"...
PMC11739670	This observation is consistent with the suggestion that MHCI alleles with higher affinity for CD8 will result in the selection of TCRs with a correspondingly lower affinity for pMHCI of that particular allele.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10976516	NCT01766739GL-ONC1GL-ONC1 aloneISystemic application for NSCLC patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "NCT01766739GL-ONC1GL-ONC1", "aloneISystemic", "application", "for", "NSCLC", "patients", "." ] } ]
PMC11727306	Abrin’s inhibition of protein synthesis was demonstrated with Vero (kidney) cells and milk was observed to competitively reduce this effect.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11739504	NIH/3T3 cells were transfected with the GFP-tagged Kat2b construct for 48 h, and the harvested cells were immediately separated into cytosolic and nuclear fractions.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ],...
PMC11670954	In healthy individuals, the physiological concentration of LPS is typically very low, generally less than 1 endotoxin unit (EU)/mL. However, certain conditions, such as impaired intestinal barrier function or bacterial infections, can lead to elevated levels of LPS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11209164	HSV.n212 titers were determined by a standard plaque assay on the Vero cells according to a previously published protocol .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "HSV.n212", "titers", "were", ...
PMC11773391	Immunofluorescence staining results suggested sequential increases in γ‐H2AX levels in the control group, 1 mM TMZ group and 1 mM TMZ + 1 μM vMF group.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11609529	YAP1 is a transcriptional co-activator in the Hippo pathway, which controls cell proliferation, apoptosis, and organ size, and is strongly linked to the development and progression of various cancers.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11803918	Flow cytometry measurement and quantification analysis of Ce6 cellular uptake levels in A375 cells treated with hybrid γδ-T exosomes with different functional antibodies (n = 4). (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11683130	Decreased expression of SerpinB3/4 inhibits the expression of immune cell chemokine (CXCL1,5,8) in keratinocytes (76).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Decreased", "expression", "of", "...
PMC10114490	RT-qPCR, immunofluorescence and PAS staining were performed as previously described .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "RT-qPCR", ",", "immunofluorescence", "and", "PAS", "staining", "were", "performed", "as", ...
PMC9429973	Mesenchymal stromal cells (MSC) represent one of the key cellular elements in this context.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mesenchymal", "stromal", "cells", "(", "MSC", ")", ...
PMC11792090	NK cells were labeled with CellTrace CFSE and co-cultured with CAR-T cells at a 1:1 ratio in 200 μL of medium containing an anti-CD107a antibody.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11705630	Antibodies: β-actin (4967S, Cell Signaling, Massachusetts, USA), GAPDH (GTX627408, GeneTex, CA,USA), GLDC (PA5-22102, Thermo Fisher, MA, USA), IRF9 (76684, Cell Signaling, MA, USA), STAT2 (44-362G, Thermo Fisher, MA, USA), STAT1 (AHO0832, Thermo Fisher, MA, USA), SETD2 (PA5-34934, Thermo Fisher, MA, USA), H3K36me3 (ab9050, Abcam, Cambridge, UK), H3 (4620, Cell Signaling, MA, USA), and p-H2AX (9718, Cell Signaling, MA, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11352311	After categorizing the pathways, they were mainly found to be related to metabolism, environmental information processing, cellular processes, organismal systems, and human diseases.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11727000	Due to its importance in DNA damage repair and transcription, and its general importance as a tumor suppressor gene, we sought to validate the interaction between USP44 and BRCA2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11730305	In the FTIR band related to the Co3O4@Glu-Ellagic acid NPs, the wavelengths at 669, 1067, and 1407 correspond to C-H, C-O, and C-C bonds, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9844987	Percentage of variation accounted for by each principal component is shown in brackets with the axis label.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Percentage", "of", "variation", "accounted", "for...
PMC11607764	PTBP1 genetic alterations were related to amplification and mutation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PTBP1", "genetic", "alterations", "were", "related", "to", "amplification", "and", "mutation", "." ] ...
PMC9429973	Whereas UCD is a localized reversible disease, the other three are systemic diseases with multiple lymphadenopathies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Whereas", "UCD", "is", "a", "localized", "r...
PMC11377827	F, G) USP43 depletion in 786-0 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "O", "O" ], "tokens": [ "F", ",", "G", ")", "USP43", "depletion", "in", "786", "-", ...
PMC11487720	In contrast, UV/cold shock-treated cells, which underwent BCD, had reduced levels of α-tubulin and the α-tubulin appears to be depolymerized (Fig. 5E).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11394730	Parthenolide treatment increased E-cadherin protein levels and decreased those of N-cadherin, vimentin, and snail.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Parthenolide", "treatment", "increased", "E-cadherin", "prot...
PMC9429973	In each cell division a reduction of telomeres occurs, until the Hayflick limit is reached and the cell is led to apoptosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", ...
PMC11583690	Docetaxel (DTX), a semi-synthetic anticancer agent belonging to the taxane family, is extracted from the European yew tree (Taxus baccata) and has applications in the treatment of various cancers, including prostate, ovarian, and breast cancers .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10936243	Certain specific barriers were identified by veterinarians as to why their use of bedding was limited and not provided to all cats in practices.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11082662	Our data thus indicate that SMPDL3B may serve as a robust prognostic indicator and potential therapeutic target for human cancers.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "data", "thus", ...
PMC9429973	DAC can inhibit the proliferation of SKO-007, H929, U266 cells in a dose-dependent manner.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O" ], "tokens": [ "DAC", "can", "inhibit", "the", "p...
PMC11129910	Up to 19% of women diagnosed with TNBC carry BRCA1 and BRCA2 germline mutations .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Up", "to", "19", "%", "of", "women", "diagnosed", "wi...
PMC10114490	Red dots correspond to features differentially abundant defined as FDR < 0.05 and fold change > 2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Red", "dots", "correspond", "to", "features", ...
PMC10747160	This variant (heretofore referred to as GLG-3A) was produced with M78Q mutations on both domains of the Griffithsin dimer, and after its size was verified by SDS-PAGE, its structure was verified to be similar to both WT-Grft and Q-Grft by NMR HSQC (Figure 3B and Figure S2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7229095	The rest are recent commercial CHO media according to our classificationThe cell lines tested here are developed from our CLD platform using CDM1, the results of each media here may be different in other cell linesTable 3Productivities after transfectionCDM1CDM2CDM348 h after transfection0.4–7.9 mg/L1.0–9.2 mg/L0.2–4.3 mg/LAdapted pool batch (day 3)8.5–12.6 mg/L12–13.5 mg/L5.3–10.2 mg/LAdapted pool batch (day 7)24.7–37.5 mg/L86–88 mg/L86–102 mg/LAdapted pool batch (day 11)Not detected90–110 mg/L175–210 mg/LNot detected at the indicated time point because the CDM1-adapted pool batch culture was terminated on day 7 Evaluation of media performance based on platform media Expected ranges are from internal amino acid analysis and/or references (Reinhart et al. 2015; Carrillo-Cocom et al. 2015; Pan et al. 2017).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Median WBC count 44.500/µL (0.4-395.000).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Median", "WBC", "count", "44.500/µL", "(", "0.4", "-", "395.000", ")", "." ] } ]
PMC8708099	When we analyzed the correlations after histamine treatment, IL-1β, IL-6, IL-8, TNF-α, IL1R1 and COX-2 tended to positively correlate with each other (r = 1.00, p = 0.083), and negatively correlate with IL-4, IL-10, and IL-13 (r = −1.00, p = 0.083; Figure 5A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11290772	These PBMCs were then utilized to transduce NK cells with a ROBO1 chimeric antigen receptor (CAR), resulting in the generation of ROBO1-targeted CAR NK cells (ROBO1-NK).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11529598	IHC scoring was based on the percentage of positively stained cells, and staining intensity was assessed by Image Scope software (Aperio Technologies, Inc.).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11670407	k Graphical abstract.	[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "k", "Graphical", "abstract", "." ] } ]
PMC11225860	U2932 cells treated for five days with 1uM alisertib or DMSO, were fixed onto microscope slides using 5% paraformaldehyde solution, and treated with a nuclear extraction buffer (10mM PIPES,100mM NaCl, 300mM sucrose, 3mM MgCl2,1mM EGTA, 0.5% tritionx-100) to remove the cell membrane and cytoplasm.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11534377	After analyzing the transcriptional alterations in the A549 cell line post-treatment with 5-Aza, as evidenced through microarray analysis, we identified a subset of ten genes for subsequent validation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11657744	Quantification of ciliary length Cep89 and Cep89 MEFs is shown.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Quantification", "of", "ciliary", "length", "Cep89", "and", "Cep89", "MEFs", "is", "shown", ...
PMC11705547	In addition, CAFs can also induce cisplatin resistance in bladder cancer cells by activating IGF-1/ERβ signaling and upregulating the anti-apoptotic gene Bcl-2 .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", ...
PMC11599565	This relevant observation resulting from transcriptome analysis clearly indicates the neuronal or neuroepithelial origin of some ovarian cancers and possibly of several tumor types.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11792888	Fetal bovine serum (FBS) was purchased from Biological Industries.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fetal", "bovine", "serum", "(", "FBS", ")", "was", "purchased", "from", "Biological",...
PMC11394730	PTL has been used in combination with several anticancer drugs, including inducers of reactive oxygen species (ROS), tubulin-directed medicines, anthracyclines, antimetabolites, histone deacetylase inhibitors, and mTOR inhibitors, as reviewed by Malgorzata et al. .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	SNORD3A (U3) and SNORD118 (U8) were C/D box snoRNAs ranked top by the number of their associated interactions in MV4-11 cells as well as in other cell types.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5916734	These vectors allow one to perform the methotrexate- driven amplification of the genome-integrated target genes and co-transfect auxiliary genes linked to various resistance markers.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11127909	As the cell viability assay data showed, 143B-EFHD1 cells exhibited a higher IC50 than 143B-V cells regardless of whether they were treated with ADR or MTX.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC11792090	Additionally, replacing IL-2 with IL-7 and IL-15 in the culture media showed beneficial effects for the long-term survival and anti-tumor function of UCAR-T cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11300639	Data are presented as the mean ± SEM of three replicates for in vitro assay and fix replicates for in vivo assay. ***,	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC7642379	In line with this, retinol metabolism was found to be down-regulated in suspension cells in the metabolic gene set analysis (Fig. 4b).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9429973	Image: Summary/Conclusion: The high frequency of CD319-positive patients was not accompanied by detection of sSLAMF7 in 61% of patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Image", ":",...
PMC10237474	The gel was visualized by stain-free imaging. *	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "gel", "was", "visualized", "by", "stain-free", "imaging", ".", "*" ] } ]
PMC11566417	Future work should focus on exploring potential storage methods specifically for MDEC CM, evaluating all the observed functional properties after long-term storage by either ultra-freezing or lyophilization.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The PKDD is a self-administered, 7-item daily diary to assess the signs and symptoms of PK deficiency (including jaundice, tiredness, and shortness of breath), while the PKDIA is a 12-item weekly measure assessing the impacts of PK deficiency (pts rated the frequency of occurrence or difficulty of various activities).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10380508	RCC has the highest mortality rate amongst the urogenital cancers, with kidney renal clear cell carcinoma (KIRC), kidney renal papillary cell carcinoma (KIRP), and kidney chromophobe carcinoma (KICH) being the most common subtypes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9250505	A NPB and PARP inhibitor combination efficacy in PDOs: effect of NPB (N), PARP inhibitors (Olaparib (O), Rucaparib (R), Talazoparib (T)) or combination treatment for 9 days in 4 EOC patient-derived organoids (PDOs), namely PDO1-4 were evaluated using the ApoTox-Glo Triplex Assay Kit for survival fraction (SF) and caspase3/7 activity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11629192

Protein A immunoadsorption (IA) was initiated, with four sessions every other day, followed by a second IVIG course.

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PMC9429973

However, more studies are necessary for validating our data.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "more", "studies", "are", "necessary", "for", "validating", "our", "data", ...

PMC9786247

The differences in replication efficiencies that we observed in the present study were minor, even though strains of the MLVA genotype II, on average, replicated significantly better than genotype I strains.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11394227

For disulfide bond folding, HCs and LCs are translocated to the ER; HCs and LCs co-translate the translocations to the ER for disulfide bond folding .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11127909

The results showed that only the truncated form of EFHD1 that retained its N-terminal region interacted with ANT3, suggesting that the N-terminal region is crucial for binding (Fig. 5C).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10522430

Furthermore, the study elucidated the underlying mechanism of GACP-induced apoptosis, particularly through the intrinsic pathway.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "the", "study", "elucidated", ...

PMC6461034

Add 1 ml cold IP buffer per 10 mg protein input to the bead pellet and mix by inverting five times.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Add", "1", "ml", ...

PMC11413393

In addition, DDR genes such as FANCM, FANCD2 and BRCA2 are decreased at both the transcriptional and protein level, thus DSBs that result from the presence of unresolved R-loops are not repaired.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10899471

As shown in Figure 4C , luciferase reporter assays confirmed that overexpression of miR-939-3p suppressed the luciferase activity of wild-type (WT) recombinant BATF2 3’ UTR.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC7612475

Cells were resuspended in 10 mL Carnoy solution and cells left overnight at 4°C.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "resuspended", "in", "10", "mL", ...

PMC10470467

Hence, these results enlighten us that CHMP7 plays a unique role in ES, which is worthy of our in-depth study.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Hence", ",",...

PMC10142392

Generally, structures with high curvature (such as spherical micelles) are formed when Cpp < 1/3, cylindrical micelles are formed when 1/3 ≤ Cpp < 1/2, and low curvature bilayer membranes are formed when 1/2 ≤ Cpp < 1 (Figure 11).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11727638

The medium was replaced every 2–3 days (Figure 1).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "medium", "was", "replaced", "every", "2–3", "days", "(", "Figure", "1", ...

PMC10538569

at 6 hours, 1, 2, 3, 6, 9 and 12 days, small portions of cell suspension were harvested and replaced with fresh complete RPMI 1640 medium and human rIL-2 (100 IU/ml).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC8557138

Ghosh et al., developed an in vitro melanoma angiogenesis model employing multicellular tumor spheroids arising from differentiated (HBL) or undifferentiated (NA8) melanoma cell lines with the aim to determine the correlation of expression with respect to the differentiation marker of cancer cells along with angiogenesis (Ghosh et al. 2007).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "B-CellLine", "...

PMC10048572

NGS also provides information about subclones of solid tumors and is used to study tumor metastatic patterns.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "NGS", "also", "provides", "information", "about",...

PMC10631132

In view of clinical translation, a fully defined differentiation process without the use of FBS for terminal OC differentiation will be needed .

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PMC11387401

First of all, the interactome was determined in cell lines rather than primary CD4 + T-cells, to meet the large number of cells needed for nRIPseq.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11537649

Direct binding of the indicated molecules was verified by an RNA-binding protein immunoprecipitation assay and a dual luciferase reporter assay.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Direct", "binding", "of", ...

PMC11628309

Many of these models are derived from human cells, bridging the gap between animal studies and clinical trials on patients, thus contributing to the searching and understanding of the mechanisms associated with potential drugs (Slanzi et al., 2020).

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PMC11687663

There is very limited research on LC-MS profiling for A. helferiana.

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PMC11045125

Thus, the tumor derived cell lines derived from ΔEBNA2 + Myc lymphomas (except for the LMP1-expressing R3 line) more closely resemble human EBV+ BLs in comparison to the P493-6 cell line.

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PMC8316344

TRIB2 has the capacity to reduce global Ub ; however, TRIB2 is upregulated in liver cancer cells .

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PMC11462673

Collectively, the findings of our research highlight the particular upregulation of the LDB1 gene in T-ALL, and an increased level of LDB1 is linked to a negative outlook, underscoring the significant pathogenic role of LDB1 in T-ALL patients.

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PMC11803149

GSEA was performed using scRNA-seq data obtained in Figure 4 .

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PMC11799620

This analysis demonstrates that the increment in the extraction time over 10 minutes lowers the phenolic content.

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PMC11760643

The original study of Buell et al. demonstrated an IC50 of 0.0008 µg/mL for 2′,3′‐(4‐benzoyl)‐benzoyl‐ATP‐induced nucleotide currents into HEK‐P2X7 cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "The", "original", "...

PMC9429973

S. Sciabolacci, L. Ruggeri, V. Cardinali, L. Brunetti, S. Tricarico, S. Saldi, F. Marzuttini, M. Griselli, G. Perta, V. Viglione, G. Cimino, A. Osmani, M. Caridi, R. Sembenico, A. Terenzi, T. Zei, R. Iacucci Ostini, M. F. Martelli, B. Falini, A. Velardi, C. Aristei, C. Mecucci, A. Carotti, M. P. Martelli, A. Pierini Division of Hematology and Clinical Immunology; Department of Surgical and Biomedical Science, Perugia General Hospital, Perugia, Italy Background: Patients with newly diagnosed acute myeloid leukemia with myelodysplasia-related changes (MRC-AML) or therapy-related AML (t-AML) have an extremely poor prognosis.

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PMC10589262

The H-score method, which assigns an IHC H-score to each case on a continuous scale of 0–300 based on the percentage of cells at different staining intensities, was used for the interpretation of KIT and ATF6 results.

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PMC9429973

Median CD8+ >200 (200-1300/μL) was first observed 4 months post BMT in Sib and Haplo and 7 months in MUD.

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PMC10588957

Proteins were separated by SDS-polyacrylamide gel electrophoresis (SDS-PAGE) and transferred to a polyvinylidene fluoride (PVDF) membrane.

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PMC9429973

Annual prevalence analysis of cohort 1 AEs showed reduced prevalence of hemorrhage over time and lower prevalence with ZANU vs IBR at all intervals.

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PMC9429973

The nucleotide sequence of CRBN and amino acid sequence were downloaded from NCBI and UniProt respectively.

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PMC11583690

BPMO@DTX, MSN@DTX, and pure DTX (same amount as the amount loaded onto the nanomaterials) samples were dispersed via ultrasonication in 10 mL of a release medium containing PBS + 0.1 % (v/v) tween 80 (pH 7.4) and then placed into the diffusion cells and sealed tightly at both ends.

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PMC3675084

BPR0L075 blocks cell cycle at the G2/M phase in paclitaxel-resistant cells while equal concentration of paclitaxel treatment was ineffective.

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PMC9429973

Non-haematological toxicity was reported in 19 (43%) patients (most commonly fatigue (n=4), insomnia (n=3), bone pain (n=2), back pain (n=2), nausea (n=2), fluid retention (n=2)), with only 2 (4%) patients experiencing grade 3-4 toxicity (fatigue in both cases).

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PMC10994876

Subsequently, the cells were suspended again in 500 mL of PBS.

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PMC11607638

No difference in SKR mRNA expression was found between SK‐injected experimental groups and DEPC water‐injected control (Figure 3D).

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PMC6267596

Time-lapse imaging of single viable polyploid cells demonstrated that DIAP cells divide by reductive cell divisions in the absence of drug.

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PMC11767817

The assay was performed for compounds 2a and 2a-B under normoxic conditions.

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PMC5386478

However, the regulatory mechanisms of TG2 in cell death require additional studies.

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PMC11754784

Therefore, macrophages that phagocytosed cancer cells will be stained by Far Red and exhibit enhanced fluorescence in Far Red channel.

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PMC11621493

Primary cells were isolated from the epidermis of two-day-old neonatal mice and cultured for four days in the presence of low CaCl2 concentrations (0.06 mM).

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PMC11718817

He et al. used three-dimensional tumor cultures seeding human primary monocytes into the spheroid upon formation .

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PMC11739670

This observation is consistent with the suggestion that MHCI alleles with higher affinity for CD8 will result in the selection of TCRs with a correspondingly lower affinity for pMHCI of that particular allele.

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PMC10976516

NCT01766739GL-ONC1GL-ONC1 aloneISystemic application for NSCLC patients.

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PMC11727306

Abrin’s inhibition of protein synthesis was demonstrated with Vero (kidney) cells and milk was observed to competitively reduce this effect.

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PMC11739504

NIH/3T3 cells were transfected with the GFP-tagged Kat2b construct for 48 h, and the harvested cells were immediately separated into cytosolic and nuclear fractions.

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PMC11670954

In healthy individuals, the physiological concentration of LPS is typically very low, generally less than 1 endotoxin unit (EU)/mL. However, certain conditions, such as impaired intestinal barrier function or bacterial infections, can lead to elevated levels of LPS.

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PMC11209164

HSV.n212 titers were determined by a standard plaque assay on the Vero cells according to a previously published protocol .

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PMC11773391

Immunofluorescence staining results suggested sequential increases in γ‐H2AX levels in the control group, 1 mM TMZ group and 1 mM TMZ + 1 μM vMF group.

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PMC11609529

YAP1 is a transcriptional co-activator in the Hippo pathway, which controls cell proliferation, apoptosis, and organ size, and is strongly linked to the development and progression of various cancers.

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PMC11803918

Flow cytometry measurement and quantification analysis of Ce6 cellular uptake levels in A375 cells treated with hybrid γδ-T exosomes with different functional antibodies (n = 4). (

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PMC11683130

Decreased expression of SerpinB3/4 inhibits the expression of immune cell chemokine (CXCL1,5,8) in keratinocytes (76).

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PMC10114490

RT-qPCR, immunofluorescence and PAS staining were performed as previously described .

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PMC9429973

Mesenchymal stromal cells (MSC) represent one of the key cellular elements in this context.

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PMC11792090

NK cells were labeled with CellTrace CFSE and co-cultured with CAR-T cells at a 1:1 ratio in 200 μL of medium containing an anti-CD107a antibody.

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PMC11705630

Antibodies: β-actin (4967S, Cell Signaling, Massachusetts, USA), GAPDH (GTX627408, GeneTex, CA,USA), GLDC (PA5-22102, Thermo Fisher, MA, USA), IRF9 (76684, Cell Signaling, MA, USA), STAT2 (44-362G, Thermo Fisher, MA, USA), STAT1 (AHO0832, Thermo Fisher, MA, USA), SETD2 (PA5-34934, Thermo Fisher, MA, USA), H3K36me3 (ab9050, Abcam, Cambridge, UK), H3 (4620, Cell Signaling, MA, USA), and p-H2AX (9718, Cell Signaling, MA, USA).

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PMC11352311

After categorizing the pathways, they were mainly found to be related to metabolism, environmental information processing, cellular processes, organismal systems, and human diseases.

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PMC11727000

Due to its importance in DNA damage repair and transcription, and its general importance as a tumor suppressor gene, we sought to validate the interaction between USP44 and BRCA2.

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PMC11730305

In the FTIR band related to the Co3O4@Glu-Ellagic acid NPs, the wavelengths at 669, 1067, and 1407 correspond to C-H, C-O, and C-C bonds, respectively.

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PMC9844987

Percentage of variation accounted for by each principal component is shown in brackets with the axis label.

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PMC11607764

PTBP1 genetic alterations were related to amplification and mutation.

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PMC9429973

Whereas UCD is a localized reversible disease, the other three are systemic diseases with multiple lymphadenopathies.

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PMC11377827

F, G) USP43 depletion in 786-0 cells.

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PMC11487720

In contrast, UV/cold shock-treated cells, which underwent BCD, had reduced levels of α-tubulin and the α-tubulin appears to be depolymerized (Fig. 5E).

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PMC11394730

Parthenolide treatment increased E-cadherin protein levels and decreased those of N-cadherin, vimentin, and snail.

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PMC9429973

In each cell division a reduction of telomeres occurs, until the Hayflick limit is reached and the cell is led to apoptosis.

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PMC11583690

Docetaxel (DTX), a semi-synthetic anticancer agent belonging to the taxane family, is extracted from the European yew tree (Taxus baccata) and has applications in the treatment of various cancers, including prostate, ovarian, and breast cancers .

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PMC10936243

Certain specific barriers were identified by veterinarians as to why their use of bedding was limited and not provided to all cats in practices.

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PMC11082662

Our data thus indicate that SMPDL3B may serve as a robust prognostic indicator and potential therapeutic target for human cancers.

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PMC9429973

DAC can inhibit the proliferation of SKO-007, H929, U266 cells in a dose-dependent manner.

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PMC11129910

Up to 19% of women diagnosed with TNBC carry BRCA1 and BRCA2 germline mutations .

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PMC10114490

Red dots correspond to features differentially abundant defined as FDR < 0.05 and fold change > 2.

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PMC10747160

This variant (heretofore referred to as GLG-3A) was produced with M78Q mutations on both domains of the Griffithsin dimer, and after its size was verified by SDS-PAGE, its structure was verified to be similar to both WT-Grft and Q-Grft by NMR HSQC (Figure 3B and Figure S2).

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PMC7229095

The rest are recent commercial CHO media according to our classificationThe cell lines tested here are developed from our CLD platform using CDM1, the results of each media here may be different in other cell linesTable 3Productivities after transfectionCDM1CDM2CDM348 h after transfection0.4–7.9 mg/L1.0–9.2 mg/L0.2–4.3 mg/LAdapted pool batch (day 3)8.5–12.6 mg/L12–13.5 mg/L5.3–10.2 mg/LAdapted pool batch (day 7)24.7–37.5 mg/L86–88 mg/L86–102 mg/LAdapted pool batch (day 11)Not detected90–110 mg/L175–210 mg/LNot detected at the indicated time point because the CDM1-adapted pool batch culture was terminated on day 7 Evaluation of media performance based on platform media Expected ranges are from internal amino acid analysis and/or references (Reinhart et al. 2015; Carrillo-Cocom et al. 2015; Pan et al. 2017).

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PMC9429973

Median WBC count 44.500/µL (0.4-395.000).

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PMC8708099

When we analyzed the correlations after histamine treatment, IL-1β, IL-6, IL-8, TNF-α, IL1R1 and COX-2 tended to positively correlate with each other (r = 1.00, p = 0.083), and negatively correlate with IL-4, IL-10, and IL-13 (r = −1.00, p = 0.083; Figure 5A).

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PMC11290772

These PBMCs were then utilized to transduce NK cells with a ROBO1 chimeric antigen receptor (CAR), resulting in the generation of ROBO1-targeted CAR NK cells (ROBO1-NK).

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PMC11529598

IHC scoring was based on the percentage of positively stained cells, and staining intensity was assessed by Image Scope software (Aperio Technologies, Inc.).

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PMC11670407

k Graphical abstract.

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PMC11225860

U2932 cells treated for five days with 1uM alisertib or DMSO, were fixed onto microscope slides using 5% paraformaldehyde solution, and treated with a nuclear extraction buffer (10mM PIPES,100mM NaCl, 300mM sucrose, 3mM MgCl2,1mM EGTA, 0.5% tritionx-100) to remove the cell membrane and cytoplasm.

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PMC11534377

After analyzing the transcriptional alterations in the A549 cell line post-treatment with 5-Aza, as evidenced through microarray analysis, we identified a subset of ten genes for subsequent validation.

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PMC11657744

Quantification of ciliary length Cep89 and Cep89 MEFs is shown.

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PMC11705547

In addition, CAFs can also induce cisplatin resistance in bladder cancer cells by activating IGF-1/ERβ signaling and upregulating the anti-apoptotic gene Bcl-2 .

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PMC11599565

This relevant observation resulting from transcriptome analysis clearly indicates the neuronal or neuroepithelial origin of some ovarian cancers and possibly of several tumor types.

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PMC11792888

Fetal bovine serum (FBS) was purchased from Biological Industries.

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PMC11394730

PTL has been used in combination with several anticancer drugs, including inducers of reactive oxygen species (ROS), tubulin-directed medicines, anthracyclines, antimetabolites, histone deacetylase inhibitors, and mTOR inhibitors, as reviewed by Malgorzata et al. .

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PMC9429973

SNORD3A (U3) and SNORD118 (U8) were C/D box snoRNAs ranked top by the number of their associated interactions in MV4-11 cells as well as in other cell types.

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PMC5916734

These vectors allow one to perform the methotrexate- driven amplification of the genome-integrated target genes and co-transfect auxiliary genes linked to various resistance markers.

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PMC11127909

As the cell viability assay data showed, 143B-EFHD1 cells exhibited a higher IC50 than 143B-V cells regardless of whether they were treated with ADR or MTX.

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PMC11792090

Additionally, replacing IL-2 with IL-7 and IL-15 in the culture media showed beneficial effects for the long-term survival and anti-tumor function of UCAR-T cells.

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PMC11300639

Data are presented as the mean ± SEM of three replicates for in vitro assay and fix replicates for in vivo assay. ***,

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PMC7642379

In line with this, retinol metabolism was found to be down-regulated in suspension cells in the metabolic gene set analysis (Fig. 4b).

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PMC9429973

Image: Summary/Conclusion: The high frequency of CD319-positive patients was not accompanied by detection of sSLAMF7 in 61% of patients.

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PMC10237474

The gel was visualized by stain-free imaging. *

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PMC11566417

Future work should focus on exploring potential storage methods specifically for MDEC CM, evaluating all the observed functional properties after long-term storage by either ultra-freezing or lyophilization.

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PMC9429973

The PKDD is a self-administered, 7-item daily diary to assess the signs and symptoms of PK deficiency (including jaundice, tiredness, and shortness of breath), while the PKDIA is a 12-item weekly measure assessing the impacts of PK deficiency (pts rated the frequency of occurrence or difficulty of various activities).

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PMC10380508

RCC has the highest mortality rate amongst the urogenital cancers, with kidney renal clear cell carcinoma (KIRC), kidney renal papillary cell carcinoma (KIRP), and kidney chromophobe carcinoma (KICH) being the most common subtypes.

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PMC9250505

A NPB and PARP inhibitor combination efficacy in PDOs: effect of NPB (N), PARP inhibitors (Olaparib (O), Rucaparib (R), Talazoparib (T)) or combination treatment for 9 days in 4 EOC patient-derived organoids (PDOs), namely PDO1-4 were evaluated using the ApoTox-Glo Triplex Assay Kit for survival fraction (SF) and caspase3/7 activity.

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