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PMC9429973
Our results suggest that novel targeted therapies may mitigate the adverse risk profile of IGLV3-21 CLL.
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PMC9509578
The hydrophobic core has the advantage of being able to entrap hydrophobic drugs within its core.
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PMC8009078
The 5 hydroxyl functional groups present in the chromone ring in Sanggenol L were found to form two H bonds with amino residues such as Lys449 and Gln377, respectively.
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PMC9429973
Median (range) hemoglobin (g/dl), platelet countx10/L, total leucocyte count x10/, monocytes x10/ and blast (%) was 9.3(5.7-14.2), 2(2-249), 35.2(3.4-145.8), 6.5(1.3-26.1) and 6(1-19) respectively.
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PMC11683130
Therefore, we speculate that similar to SerpinA3, SerpinA1 is involved in the pathogenesis of GPP through loss-of function mutations, but further studies are needed to confirm it ( Figure 2 ).
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PMC11400680
The range of spherical values that our model can segment is (from ~0.1 to ~0.92) for cells and (from ~0.3 to ~0.98) for the nucleus.
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PMC11655498
For instance, a combined analysis of metabolomics and transcriptomics has identified IDO1 as a critical host factor for establishing EBV latency in B cells; inhibiting IDO1 disrupts EBV-induced B cell transformation (Müller-Durovic et al., 2024).
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PMC10747160
In short, B cells engage in numerous different functions and roles within the mammalian body, and so there are many confounding variables that could explain why Raji cells—as a B-cell-derived cell line—could undergo Griffithsin-enhanced trans-infectivity of SARS-CoV-2 pseudotyped virions .
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PMC9532503
The glycoengineering process used for the generation of second and third generation antibodies is time consuming, tedious and needs more resources.
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PMC11770130
Adipose tissue-derived secretary proteins, from either the adipocytes or stromal vascular fraction (SVF), tightly modulate the metabolic activity in many organs.
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PMC10667689
Since metabolic reprogramming in AML is a dynamic object of interest and several therapies are based on metabolic inhibitors (27), checking over the basics of these alterations, and particularly, identifying the upstream molecules that manipulate metabolic pathways in AML should be carried out to determine the role of leukemia-related markers.
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PMC9429973
RBC show aberrant morphology and aggregation of b-globin tetramers on RBC membranes.
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PMC11803918
DCFH-DA was purchased from MedChemExpress (Shanghai, China).
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PMC11244823
The plate was sealed as described above and incubated on a plate shaker for 1 h at 4°C.
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PMC11394227
The fluorescence of PE was detected in the FL2 channel, and the fluorescence of 7-AAD was detected in the FL3 channel.
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PMC7642379
These results indicate a genomic divergence of the clonal lineages compared to the parental HEK293 and suggest the presence of similar transcriptomic traits between HEK293 progeny cell lines individually selected for during the isolation of each clone.
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PMC11745823
For IHC, formalin‐fixed, paraffin‐embedded tissue slices with a thickness of 4 μm were produced.
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PMC10988555
Cells were seeded at a density of 2 × 10 cells/well in 6-well plates and incubated for 24 h. Posteriorly, the medium was replaced by medium with DMSO 0.1% (v/v), vehicle control, 0.4 μM DOX and 5 μM cisplatin, positive controls, or IC50 of the complexes 2–4.
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PMC10507284
In the cohort that received immunotherapy (Imvigor210), the CR/PR and SD/PD proportions in the low TROAP expression group were 21 and 79%, respectively.
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PMC9878562
By contrast, IF analysis of axillary lymph node sections from mice bearing VAL-wt:Val-ko tumors revealed striking differences in the distribution of the two cell populations.
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PMC11543853
d Virions are released into the cytoplasm.
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PMC11536589
Scale bar: 100 μm.
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PMC11015054
The tissue sections were observed under a laser confocal microscope.
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PMC9545474
Evaluation of efficacy in s.c.
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PMC7602170
The pathological feature of spindle cell type is a spiral or palisading arrangement, in which the nuclei of tumor cells are fat to slender or fusiform with perinuclear vacuolization, and the cytoplasm of the tumor cells is eosinophilic or light-stained with mild atypia (Figure 1A).
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PMC10329074
The YBX3 mRNA expression were examined through qRT-PCR. (
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PMC11541409
At the molecular level, inhibition of relevant membrane receptor tyrosine kinases (RTKs) such as VEGFR, KIT, PDGFR, FGFR, MET, FLT3, and AXL offers the potential to reverse the resistance phenotype in advanced GIST by inhibiting activation and re-activation of MAPK/ERK and PI3K/AKT pathways.
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PMC11538390
Transgenic embryos were assayed at embryonic day 13.5.
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PMC10808409
IC50 values were calculated showing a prominent IC50 for them against Caco-2.
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PMC11371747
In general l-LV acts similar to the dl-LV formulations, however disparate effects were observed when d-LV and l-LV were used in combination, conceivably by d-LV affecting (anti)folate transport and intracellular metabolism.
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PMC11012012
Up to 60% specific cell lysis was observed with cHuLym3 in ADCC assays.
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PMC8193046
Compounds 7–11 were derived from C@PA as reported by Namasivayam et al. in 2021 .
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PMC11499381
The CLR-C-V1–154/RAMP1 receptor showed significantly less HA and myc immunoreactivity than the WT CGRP receptor in both cell lines (Figure 3B,C, Supplementary Figure S5B,C), suggesting reduced cell surface expression.
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PMC11075223
In addition to the above compounds, phenolic glycosides , aromatic carboxylic acids, quinone compound, flavonoids and oligosaccharides were reported from Cimicifugae Rhizoma.
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PMC11594641
The supernatant was collected and stored at −20 °C until further use.
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PMC8751435
The cell lysates were collected and centrifuged at 12,000 g at 4℃ for 10 min.
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PMC9895440
Low passage T2 cells (source DSMZ) were electroporated with crRNA-tracrRNA-Cas9 complexes targeting human CD80 and CD86 (see sequences above) using the CA148 program in SE buffer at 0.4 Mio cells / 20 μl in a 16-well strip cuvette.
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PMC9964635
IR: ν (cm): 3370, 1670, 1528, 1470, 1306, 659.93.
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PMC9429973
Mortality in the group who did not receive CT was 35.7%, and in the group who received CT - 22.2%.
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PMC3035438
Reactivity of the chimeric IgG of apoferritin-specific clone #12 to different antigens before and after purification with a protein G affinity chromatography column. (
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PMC9429973
Methods: The planned 6 patients were enrolled: 5 in 1 CHR and 1 in 2 CHR.
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PMC9581083
Yu Xing Cao (Cynoglossum austroafricanum Hilliard and B.L. Burtt), Mai Men Dong (Ophiopogon japonicus (Thunb.)
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PMC10125312
Quantification of AuNR-PEG in different cell types and tissues was performed to detect uptake performance differences.
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PMC8358006
Fig. 2The distribution of grand H3K27me3 silencer domains is correlated with the 3D genome organization.a Example of Hi-C contact maps at 15-kb resolution of the genomic region Chr.17 49.3–50.1 Mb in normal lung fibroblast cell line IMR90.
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PMC11453018
C Annexin V staining (histogram) of SKES1 cells in the condition described above.
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PMC11738017
∗∗∗P ≤ .001; ∗∗∗∗P ≤ .0001.
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PMC9429973
Methods: This is a prospective, multicenter data-based platform.
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PMC11486946
For the compound-dose dependent assay shown in Fig. 2d and e, cells were treated with 100 µL of 10 µM, 1 µM, 0.1 µM, 0.01 µM, and 0.001 µM compound solution for 1 h before single-molecule imaging.
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PMC6442998
To test if KIT or PDE3A inhibition influence YAP activity, we assessed YAP localization by immunofluorescence in GIST882 and GIST48 cells treated with imatinib, cilostazol and combination of the two drugs for 72h (Figure 4A).
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PMC11126803
Related research by Yu et al. (46) showed that estrogen can inhibit the progression of renal cell cancer cells, but an increasing number of other studies have found that the role of ERβ in promoting the progression of renal cancer is more significant (25).
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PMC9429973
A. Bessudo, D. Greenwald, M. H. Kazemi, A. Mahindra, L. Shunyakov, M. Sondhi, H. O’Connor, Y. Chen, J. Yang, G. Salles cCare, Encinitas; UCLA, Santa Barbara; Astera Cancer Care, East Brunswick; Scripps MD Anderson Cancer Center, La Jolla; Central Care Cancer Center, Bolivar; Epizyme, Inc., Cambridge; Memorial Sloan Kettering Cancer Center, New York, United States of America Background: Enhancer of zeste homolog 2 (EZH2), an epigenetic regulator, suppresses key cellular checkpoints and differentiation pathways to maintain the oncogenic characteristics of germinal center B cells.
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PMC10729469
Table contains p-values for slopes and intercepts of Treg functions compared by linear regression analysis, n = 3.
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PMC10142392
Additionally, functional and intelligent fabrics can be made by blending two different materials and electrospinning composite fibers.
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PMC10079526
To investigate proteins that can serve as predictive biomarkers for successful combination treatment, we evaluated protein expression levels of candidate biomarkers including DNMT1, MYC, SUMO E1 enzyme UBA2 and SUMO E2 enzyme UBC9 as well as conjugation levels of SUMO1 and SUMO2/3 by immunoblotting (Fig. 4F).
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PMC9812014
It can be inferred that this alkaloid is more potent than the anti-retroviral drug lamivudine used in this experiment as a positive control .
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PMC11792888
Bar graph from cleaved caspase 3/total caspase 3 ratio.
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PMC10213179
Aptamer treatment in an in vivo orthotopic mouse model: animal models for tumor growth or metastatic detection were performed as described by López-Alemany and Tirado.
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PMC9429973
Measuring MRD <10 could help to further distinguish between CLL patients with durable remission and those at risk of early relapse.
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PMC11730311
Cells were incubated with 24 pM hαCGRP (EC90) and increasing concentrations of antagonist.
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PMC9429973
A total of 17 SAEs (CTC grade 3 or greater) were reported (GO1, n=11, GO2 n= 6).
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PMC9429973
Ibrutinib resistance in 50-80% of cases is associated with the C481S mutation in exon 15 of the BTK gene (Ahn et al, 2017; Woyach et al, 2017), which corresponds to the c.1441T>A and c.1442G>C substitutions, still, other variants of gene mutations at this position are also reported.
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PMC11359735
The level of myo-inositol content in strips 4 and 5 was lower than for strip 3 but remained higher than for strips 1 and 2 (Fig. 3B).
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PMC9712534
Effects of etoposide on the viabilities of H58Y/WT and WT/WT cells.
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PMC11747949
To describe cell phenotype comparing mono‐ and co‐cultures, we performed multiple variables analysis of surface protein expression changes in hypoxia.
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PMC11699178
In tumor tissues, VEGFB prevents excessive angiogenesis by inhibiting the FGF2/FGFR1 pathway .
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PMC10114490
We seeded 240 wells rendering a total of 57 grown clones and 13 of them were above 90% GFP-positive after a 48-h Dox pulse (i.e., Dox responsive).
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PMC5916734
The objective of this study was to produce and characterize these cell lines that secrete FIX.
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PMC11046454
To generate a human xenograft tumor mouse model, female NOD/ShiLtJGptPrkdIl2/Gpt (NCG) mice were subcutaneously (s.c.)
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PMC9919300
A rodent model of NAFLD has shown that an analog of andrographolide, isoandrographolide, ameliorates the hepatic parameters with a reduction in the transaminases and the lipid profile reducing the storage and serum lipid content .
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PMC10421378
In conclusion, the cells that sustained membrane damage were divided into three groups (mid-active I, mid-active II, and dead) using IFC on the basis of the severity of the damage.
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PMC9429973
Association between categorical variables was observed using the chi-square test or Fisher’s exact test.
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PMC10170482
It is known that the accumulation of collagen types I and III is associated with liver ECM reorganization during the course of various pathologies, including liver cancer.
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PMC11803918
Human PBMCs were isolated from buffy coats of healthy donors from the Hong Kong Red Cross through a Ficoll-Hypaque gradient centrifugation.
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PMC11412721
Thus, the biological importance of many p53 isoforms remains elusive.
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PMC9847912
Because infectious virus production and virus-induced syncytia formation can vary markedly between different HIV and SIV molecular clones, it was necessary in some cases to dilute the 293T/17 supernatants prior to their use in infecting the MAGIC-5A cells to avoid syncytial lysis.
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PMC9429973
Median time to neutrophil engraftment was 21 days [range 15-24].
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PMC11049548
A2780 and A2780is cells were purchased from Creative Bioarray, Frankfurt, Germany, (A2780: human ovarian carcinoma; catalogue no.: CSC-C9491J, passage no.: P + 8.
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PMC11155445
Three novel acyl thioureas (171a–c) were synthesized and investigated as extractants for the removal of Cu(ii) ions from water.
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PMC7039683
We found a third periderm enhancer 8.3 kb upstream of the transcriptional start site of PPL (encoding Periplakin) (PPL-8.3), whose mouse ortholog is highly expressed in periderm (Li et al., 2019) and contributes to epidermal barrier formation (Sevilla et al., 2007).
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PMC9920575
This study shows that S. chinantlense extract inhibits proliferation in the cancer cell line HeLa and in the nontumorigenic cell line HaCaT. Additionally, the extract increased the percentage of cells in the SubG1 phase, translocation of phosphatidylserine (PS), release of cytochrome-c, and activation of p53 and caspase-3 (Figure 2, Figure 3, Figure 4 and Figure 6; Table 2.
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PMC11766174
For the detection of HIV-p24, two anti-CA mAbs (anti-CA HIV-018-48304 and anti-CA 801136; Table 3) were combined to increase the staining sensitivity.
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PMC7215832
RX-3117 induced PCFT functionality (increased gene and protein expression and increased transmembrane transport) which is likely the result of hypomethylation of the PCFT promoter as was also seen in earlier studies with DAC, which was included as a positive control in our studies.
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PMC11423992
Scale bar, 20μm. (
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PMC11740207
Cellular debris, comprising fragments resulting from cellular disintegration, apoptosis, or other cellular activities, can be mistakenly identified as living cells during flow cytometry analysis.
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PMC11361748
The “innate immune system” and “neutrophil degranulation” were the pathways most significantly enriched in a K17-dependent fashion; moreover, virtually all other pathways showing significant enrichment relate to neutrophil or innate immune processes (Figs 2I and S2G).
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PMC11754432
The enhanced cytokine secretion from ALOX15B silencing keratinocytes implies a role in immune cell chemotaxis, which should be explored in the future.
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PMC11572213
In further studies, TET2 expression can be completely silenced by the CRISPR/Cas9 gene editing method, and the mRNA expression and protein levels of genes related to glutamine metabolism, such as GLUL, GLS1, GLS2, and GLUD1, can also be examined.
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PMC9581083
LHC has proven effective in the treatment of seasonal influenza.
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PMC9219615
To monitor the mitochondrial integrity of cells exposed to Tpz-1, changes in mitochondrial membrane potential were studied via MitoProbe JC-1 Assay Kit (Molecular Probes, M34152).
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PMC11240448
We showed that cSTAR copes with these challenges by providing a classification of both the BC and non-malignant breast tissue cell lines, while also suggesting interventions to normalize DPD scores.
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PMC9429973
Baseline characteristics were balanced between MajesTEC-1 and DREAMM-2 after reweighting the MajesTEC-1 cohort.
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PMC11763111
7LLT1-overexpressing UCAR-T cells demonstrate potent anti-tumor activity in humanized T-ALL models.
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PMC9429973
A. H. Wei, H. Döhner, H. Sayar, F. Ravandi, P. Montesinos, H. Dombret, D. Selleslag, K. Porkka, J.-H. Jang, B. Skikne, C. Beach, T. Prebet, G. Zhang, A. Risueño, M. Ugidos Guerrero, W. L. See, D. Menezes, G. J. Roboz Department of Clinical Haematology, Alfred Hospital, and the Australian Centre for Blood Diseases, Monash University, Melbourne, Australia; Department of Internal Medicine III, Ulm University Hospital, Ulm, Germany; Indiana University Cancer Center, Indianapolis; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, United States of America; Hospital Universitario y Politécnico La Fe, Valencia, Spain; Hematology, Hôpital Saint-Louis, Assistance Publique – Hôpitaux de Paris (AP-HP), and Institut de Recherche Saint-Louis, Université de Paris, Paris, France; AZ Sint-Jan Brugge-Oostende AV, Bruges, Belgium; HUS Comprehensive Cancer Center, Hematology Research Unit Helsinki and iCAN Digital Precision Cancer Center Medicine Flagship, University of Helsinki, Helsinki, Finland; Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea; Bristol Myers Squibb, Princeton, United States of America; BMS Center for Innovation and Translational Research Europe (CITRE, a Bristol-Myers Squibb Company), Seville, Spain; Weill Cornell Medicine and New York Presbyterian Hospital, New York, United States of America Background: In the randomized, phase 3 QUAZAR AML-001 trial, oral azacitidine (Oral-AZA) significantly prolonged overall survival (OS) compared with placebo (PBO) (median OS 24.7 vs 14.8 months [mo], respectively) in older patients (pts) with AML in first remission after intensive chemotherapy (IC).
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PMC11629192
In our study, one patient had mild allergic reactions and liver enzyme increased after the first dose of OFA, and one patient had liver enzyme increased after the second dose of OFA.
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PMC10502403
Sixty days after NE1-GMC infusion, peripheral blood was obtained from 3 mice, as shown in Figure 2A, and examined.(G) Frequencies of IFN-γ-secreting NGMC Vδ2, NE1-GMC Vδ2CD8 and NE1-GMC Vδ2CD8 cells: no stimulation (white), stimulated with PTA (gray), or NE1-pMHC (black).
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PMC9918897
The steps for preparing the solutions, and the XN and alcohol contents for each sample, are shown in Figure 5.
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PMC11468365
The model demonstrated a 7.2% improvement in predicting drug combination synergy compared to five established machine learning techniques.
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PMC11127909
Cell cycle analysis was performed by a FACSort Flow Cytometer.
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PMC9429973
Two-sided nominal p-values are reported.
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PMC11638288
3The molecular mechanism and function of NKp46 in antitumor activity.
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