OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC11461874	Consistently, overexpression of TRAF7 causing reduction of DBP levels (Fig. 4a) shortened the period length of the Bmal1-luc rhythms in cultured NIH3T3 cells (Fig. 5b).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", ...
PMC9429973	Methods: Peripheral blood (PB) and BM samples were collected from healthy individuals (n= 22) and lymphoma patients (n=50).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11538390	Real-time PCR was performed using SYBR Green qPCR mix (Bio-Rad) in Bio-Rad CFX Connect Real-Time System.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Real-time", "PCR", "was", "performed", ...
PMC11783017	Interleukin 11 receptor alpha (IL11Rα) is highly expressed in OS, especially in high-risk or advanced-stage patients, and its high expression is associated with poor prognosis in OS .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11740907	These results emphasize the possible influence of various therapies on the survival rates of mice with cancer and justify the need for more research on the mechanisms and efficacy of each therapeutic option in this experimental setting.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9503669	The YFP fragments were fused to Nef through its C-terminal tail to maintain N-myristoylation and membrane localization.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "YFP", "fragments", "were", "fused", ...
PMC11648299	Fig. 1Patients with Darier diseases a) Typical V-shaped notch at the free margin of the nail on a patient with Darier disease, b) Patient with Darier disease with acute worsening in his face due to eczema herpeticum, c) Red-scaly itching patches in the neck and face area on a patient with Darier disease, d) Red thick patches at the dorsal side of hand with red-white stripes on nails, e) Yellowish larger warty lesions covering the back of a patient with Darier disease, f) Oily crusted lesions on face, similar to seborrhoeic dermatitis, g-h) Small brown papules with a firm, harsh sandpaper-like texture on the back and neck of a patient with Darier disease, i) Patient with Darier disease who was initially misdiagnosed as having intertriginous eczema.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11300085	Moreover, the results of transwell and cell scratch also indicated that the silencing of CMKLR1 significantly (P < 0.0001) reduced invasion and migration of SK-OV-3 cells with less invading cells than chemerin treatment alone (Figure 4(d), 4(e), and 4(f)).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11127909	These results suggested that EFHD1 could promote mitochondrial functions to protect OS cells from chemotherapy stress.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "results", "suggested", "that", "EFHD1", "coul...
PMC9143157	Regarding the in vivo antitumor activity of P-THP, we adopted the dosage of 5 mg/kg for THP and 15 mg/kg (THP equivalent) for P-THP, because 15 mg/kg is almost the LD50 of free THP, of which 40% of the tumor-bearing mice died at this dose in our previous study , while the LD50 of the P-THP was reported to be higher than 60 mg/kg , and no apparent side effects were found at 15 mg/kg .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7053076	The transactivation domain is a C-terminal non-homologous domain that is important for NF-κB-mediated gene transactivation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "transactivation", "domain", "is", "a", "C-terminal", ...
PMC11098378	This mixture was incubated at room temperature for 20 min before adding dropwise to the well and incubating 48 h. The toxicity of the pIB/V5-His-based effector library was measured using a CyQUANT LDH Cytotoxicity assay (Invitrogen; S4 Table).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11765988	The development of HL seems to be the outcome of the interaction of genetics, environmental factors, and the likely impaired immune system.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC7823217	C. GFR Matrigel with formation of 3D acini ™.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "C.", "GFR", "Matrigel", "with", "formation", "of", "3D", "acini", "™", "." ] } ]
PMC10854447	Anal.	[ { "tags": [ "O", "O" ], "tokens": [ "Anal", "." ] } ]
PMC6222726	92 species) .	[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "92", "species", ")", "." ] } ]
PMC10571053	Inhibition of the antiporter leads to depletion of glutathione and inactivation of GPX4.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Inhibition", "of", "the", "antiporter", "leads", "to", "depletion", "of", ...
PMC10870498	p < 0.05 indicates that the difference is statistically significant.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "p", "<", "0.05", "indicates", "that", "the", "difference", "is", "statistically", "significant",...
PMC11766332	Of 64 studied miRNAs differently expressed and identified in at least two studies (ASD-miRNAs), we identified a subset of 25 ASD-miRNAs (39%) associated with glycosylation pathways and reported to be upregulated or downregulated in patients with ASD (Supplementary Table S1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9559528	Furthermore, syphilis should be considered as a potential precipitating or contributing factor in patients presenting with generalized EM, especially in those with HIV/AIDS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC7185206	Recombinant Fc-PD-L1 significantly reduced CD8 + T cell survival.10.1080/2162402X.2020.1744980-F0004Figure 4.Tumor-derived sPD-L1 induces activated human CD8 + T cell death and competes with PD-(l)1 inhibitors for effect on CD8 + T cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11271278	Then for every gene, two scores were calculated to account for the number and strength of interactions between a promoter and its enhancers.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11748618	Using chromatin states, regulatory motifs, and gene expression profiles, we tested the association of these variants in blood tissues from individuals of African ancestry.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC3274243	While the developments described in this publication have enhanced the potential of the technology in such fields, we recognise that further research and development is required to identify the mechanisms by which the OCP is generated and fully validate its efficacy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Summary/Conclusion: CAMMA 3 is a study of SC cevostamab monotherapy in patients with R/R MM.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Summary/Conclusion", ":", "CAMMA", "3", "is", "a", ...
PMC11803149	All statistical analysis were calculated using GraphPad Prism 10.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "statistical", "analysis", "were", "calculated", "using", "GraphPad", "Prism", "10", "." ] } ]
PMC5925824	Data are representative of multiple independent experiments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "are", "representative", "of", "multiple", "independent", "experiments", "." ] } ]
PMC6133382	Although modern production technology provides the means to express and purify properly folded recombinant glycoproteins at a large scale, controlling the glycosylation has been a persistent problem for most glycoproteins because of the “non-templated” nature of glycosylation [30–32].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7305184	Cells from EP group were exposed to pulse treatment) and then transferred to the new growing flask.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "from", "EP", "group", "were",...
PMC11697189	A, B) The top 20 mutated genes in the high-risk group (A) and low-risk group (B). (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", ...
PMC11656657	Tumor growth was monitored by IVIS imaging until day + 29 post-treatment (day + 155 post-tumor inoculation) (Fig. 4L); we observed a significant tumor regression in all CAR.GD2 T-cells treated mice compared control NT T-cells mice group (Fig. 4M).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Fractional abundance of BCL2 mutations identified by NGS was assessed retrospectively in serial peripheral blood samples by ddPCR using custom-designed, allele-specific assays.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fractio...
PMC11488203	A breast cancer hybrid cell after spontaneous fusion of MDA-MB-231 with MSC060616 is documented by the white arrowhead (bar = 25 µm) (A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC11597291	The ζ-potential of the nCGO was highly negative (−50 mV) due to the presence of –COOH groups on the lattice.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "ζ-pot...
PMC9985266	The immunofluorescence assays showed that either DNMT1 overexpression or MEG3 silencing reversed the promotion of LC3 and Beclin1 fluorescence intensity by IL-27 compared with the IL-27 group (Fig. 6E; Additional file 1: Fig. S9B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9024365	Similar to the GluA1 chimeras, we used GluK2/GluA2 chimeras to identify the region sufficient for clustering with SD4.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Similar", "to", "the", "GluA1", ...
PMC9388315	Then agitated for 30 min at 4°C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Then", "agitated", "for", "30", "min", "at", "4", "°", "C", "." ] } ]
PMC11763111	We believe that CD38 represents a valuable, broadly applicable target, and that a universal CD38-targeting CAR construct holds promise for treating various hematologic malignancies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC10976516	injected A549 cell line) xenotransplanted NSCLC model, EphA2-TEA-VV was i.v.	[ { "tags": [ "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "injected", "A549", "cell", "line", ")", "xenotransplanted", "NSCLC", "model",...
PMC10808409	The anticancer activity of FA and Tocopheryl polyethylene glycol 1000 succinate (TPGS) mixed micelles formula (O2) was assessed by MTT and flow cytometry.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11092382	However, the toxicity and safety profile of sophocarpine have not been well characterized to date.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "the", "toxicity", "and", "safety", ...
PMC11697703	We confirmed that neurons in the heterotopic clusters have reduced MAPK8 signal compared to non-electroporated nearby/adjacent neurons, as we previously showed in miR-193b and -365 electroporated layer II-III neurons (Figures 3G–3I).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6600592	Succinic anhydride (1 equiv, 25 mmol) in 30 mL CH2Cl2 reacted with substituted benzenes (1, 25 mmol) under stirring for 0.5 h in ice-water bath, then anhydrous aluminum chloride (37.5 mmol) was added to the CH2Cl2 solution (Scheme 1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8540692	A mild increase in the permeability of bisdemethoxycurcumin through the BBB was recorded after using the combination of CCM:NaBu in the ratio 1:1000 (Papp 3.618 × 10 ± 1.963 × 10 cm s).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Subgroup analyses were planned.	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "Subgroup", "analyses", "were", "planned", "." ] } ]
PMC7762347	In this regard, a previous study suggested that CYN had a prominent role in the genotoxicity of CYN/MCLR combination by the comet assay, the micronucleus assay and target gene expression on HepG2 cells , but further research was required.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11746948	Scale bar, 4 μm.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bar", ",", "4", "μm", "." ] } ]
PMC7189327	Finally, ROC analysis revealed that CYFIP2, HOXB5, PTPN3, MARCKSL1, PTCH1, and CDC20 could distinguish BCC and healthy individuals.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11759543	The one-way ANOVA with Dunnett's multiple comparisons test was used when appropriate.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "one-way", "ANOVA", "with", "Dunnett", "'s", "multiple", "comparisons...
PMC11700523	The 5/6 Nx group in this study showed decreased plasma aldosterone levels compared with the sham group.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "5/6", "Nx", "group", "in", "this", ...
PMC9351137	Scale bar = 10 μm.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bar", "=", "10", "μm", "." ] } ]
PMC9429973	Proteomic analysis by proximity-dependent Biotin Identification (BioID) was used to assess affinity of mutant Helios to its interaction partners, while single-cell RNA sequencing was applied to peripheral blood mononuclear cells (PBMCs) of two patients to study the transcriptional effect of the truncating and biallelic IKZF2 mutations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11769516	Mycotoxins’ neurotoxicity and cytotoxicity have been demonstrated by the impairment of gene expression, cell proliferation and the induction of oxidative stress.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mycotox...
PMC11568601	To explore the underlying mechanisms, 4-phenylbutyric acid (4-PBA) was selected as a specific endoplasmic reticulum (ER) stress inhibitor.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", ...
PMC9429973	Results: In the first patient, four variants affecting the genes CBL (VAF =7.4%), MPL (50%), JAK2 (51.5%) and ETV6 (10,6%) were detected at diagnosis in BM.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Cancer cells catabolize glucose to lactate in aerobic conditions: a sharp time dependent increase in extracellular lactate release was observed in MM cells over time which was suppressed by YKL-5-124 treatment via regulation of lactate dehydrogenase A (LDHA) expression and enzymatic activity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	In addition, MF pts with history of thrombocytopenia continued RUX treatment at lower doses compared with those without a history of thrombocytopenia.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", ...
PMC11461874	Statistical analysis of the data was performed with one-way ANOVA with Tukey’s correction.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Statistical", "analysis", "of", "the", "data", "was", "performed", ...
PMC10135767	As for the mechanical regulation of cellular calcium signaling, the effect of external force on the calcium bursting of T cells is induced by the TCR-pMHC complex .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11474209	The mitochondrial abnormalities in the etiology of several human illnesses linked to MC-LR exposure underline the translational relevance of innovative pharmacological treatments targeted at selective mitochondrial engineering, which might open new opportunities for developing novel therapies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11683240	α1AT, α1-antitrypsin; PT, pertussis toxin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "α1AT", ",", "α1-antitrypsin", ";", "PT", ",", "pertussis", "toxin", "." ] } ]
PMC11564322	The c-SRC inhibitor I alone increased the c-SRC kinase protein expression by 14.10%, compared to the control.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "c-SRC", "inhibitor", "I", ...
PMC11459296	with 1×10 A673 Ewing sarcoma cells (ATCC).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "with", "1", "×", "10", "A673", "Ewing", "sarcoma", "cells", "(", "ATCC", ")", ...
PMC11574271	B The IHC analysis revealed distinct staining patterns of RON protein expression in bladder cancer and adjacent normal tissues, with a total of 119 samples analyzed, including 26 normal tissues and 93 bladder cancer tissues.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9841531	The data was processed using GraphPad Prism version 8.4.0, and IC50 values were determined, applying three- or four-parameter logistic equations, whatever was statistically preferred.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11806106	Increasing concentrations of nociceptin were applied followed by a saturating concentration of nociceptin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Increasing", "concentrations", "of", "nociceptin", "were", "applied", "followed",...
PMC11779960	c Alternative mature TCL origin proposed by Thiele et al., derived from immature progenitor cells not committed on TCRβ and displaying polyclonal TCRαβ clonotypes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11755519	Tumors rapidly develop a new vascular network to promote a high proliferation rate of tumor cells (Figure 4, Table 2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Tumors"...
PMC9684669	Gene ontology (GO) enrichment analysis revealed that 13 calcium-related biological pathways were activated in the A2780-ADR cell when compared to its parental A2780 cell. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "B-CellLine", "...
PMC11786704	The results of Masson's trichrome staining and immunohistochemistry staining, including the expression of IL-6, TNF-α, and MnSOD in wound tissue were shown in Fig. 4F.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11757131	The cells were seeded in six-well plates and treated with different concentrations of 3-HIB (0, 0.2, 0.4, 0.8, and 1.6 mM) for 48 h. After treatment, cell samples were collected using a cell lysis buffer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11719944	Immune system activation is essential for pathogen control and disease prevention, but regulatory mechanisms are required to avoid immunopathology caused by overactive immune responses.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11281366	Site-directed mutagenesis of the 3′ UTR of CD59 was performed via PCR to generate mutations (see Mut (mutation) primers in Table S1) and cloned into pMIR-REPORT-Luc using the same strategy described above.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Grade (G) 1 to 2 neuropathy occurred in 19% (5/26) of evaluable patients but did not result in treatment cessation in any case.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11538390	Briefly, cells were sheared using PIXUL to obtain genomic DNA fragments averaging 300–600 bp.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Briefly", ",", "cells", "were", "sheared", "using", "PIXUL"...
PMC7334607	Point-Range Plots Demonstrating EC50 Changes in A673 Experimental and Control Replicates Over Time Bottom: Point-range plots representing the changes in drug response to a panel of nine drugs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The urgent need for the development of tailored treatments requires a better understanding of the effects of NUP98-KDM5A on the deregulation of gene expression programs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9985266	However, the underlying mechanism by which IL-27 attenuates PF is not fully clear.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "the", "underlying", "mechanism", "by", "which", ...
PMC7802142	Subsequently, the library preparations were sequenced on an Illumina Hiseq 2500 platform and paired-end reads were generated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Subsequently", ",", "the", "library", ...
PMC9261184	The figure indicates the cause of some of this variation: the split between CO2 and methane emissions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "figure", "indicates", "the", "c...
PMC10993311	T test for independent samples.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "T", "test", "for", "independent", "samples", "." ] } ]
PMC10969097	The administration of cisplatin was conducted at concentrations of 40 μM for SKOV3 and 200 μM for SKOV3/DDP, while SBSGL was given at a concentration of 200 μM. Regarding tumour volume and weight, the group that received the combination of cisplatin and SBSGL showed more pronounced inhibitory effects on tumour growth compared to the group that received treatment with cisplatin alone.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11790971	Plots were generated using Matplotlib (version 3.2.2) and Seaborn (version 0.11.0).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Plots", "were", "generated", "using", "Matplotlib", "(", "v...
PMC10728200	Significance denoted by: ns not significant, P < 0.05, P < 0.01, and **P < 0.001.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9429973	The median age at diagnosis was 54 (aged 21-65).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "median", "age", "at", "diagnosis", "was", "54", "(", "aged", ...
PMC6835428	Thus, the development of novel strategies is of the utmost urgency.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ",", "the", "development", "of", "novel", "strategies", "is", "of", ...
PMC9143157	However, pembrolizumab monotherapy has shown less activity , and chemotherapy using cytotoxic drugs remains the first-line dominant treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "pembrolizumab", "...
PMC11001582	Peaks correspond to physiological recruitment of motor units following electrical stimulation; n mice = 5 WT, 6 (GR)400 and 6 (PR)400; n muscles = 8 WT, 12 (GR)400 and 9 (PR)400.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11506670	The signaling cascade commences with the binding of epithelial growth factor (EGF) to EGFR, which sets in motion a sequential activation of downstream effectors, including RAS, RAF, MEK, and ERK.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11394112	Here, we evaluated DLBCL colonization and expansion in NSG mice expressing human IL3, CSF2, and KITLG with and without human IL6 co-expression and also in IL6-only-expressing NSG mice.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6684588	The knee was immobilized using a 27 gauge needle inserted through the knee joint and clamped to the platform (Fig. 4) or by a silk suture passed beneath the patellar tendon used to securely fasten the knee against a stationary horizontal rod (Figs. 3, 5).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10748106	For that reason, an iso-surface of −10 kcal/mol value of MEP was obtained (see Figure 3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "that", "reason", ",", ...
PMC11218145	with Ren cells.	[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "with", "Ren", "cells", "." ] } ]
PMC10976516	In addition, it became clear that systemic anticancer treatment efficacies of OV platforms derived from measles virus, vesicular stomatitis virus (VSV), reovirus, HSV, adenovirus, and parvovirus are significantly hampered or eliminated by pre-existing or therapy-induced neutralizing antibodies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11659921	Our functional analysis revealed that these genes were associated with several biological processes, including cell cycle inhibition, DNA damage response, epithelial‐mesenchymal transition (EMT) activation, androgen receptor inhibition, and RAS/MAPK pathway activation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11727062	Additionally, the study elucidated that dihydroartemisinin modulates the differentiation and expansion of immune cells within the tumor microenvironment, including CD8+ cytotoxic T lymphocytes (CTLs), CD4+ T helper cells, and regulatory T cells (Tregs), thereby augmenting the antitumor immune response in mice.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11704834	The authors are currently performing molecular genetic studies to determine which of these TFs contributes to the elevated TLE1 expression in EGFR-TKI resistant cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9577200	It is essential to mention that a high concentration of GO may be toxic to bacteria, but we want to inhibit bacteria by using low concentrations rather than high concentrations to avoid any damage.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11628904	At right, representative images show a tailfin pre‐ and post‐burn in the presence of cell impermeable FM dye.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "At", "right", ",", "representativ...
PMC8526701	In the current study, we investigated the correlation between the expression of BRD9 and the inhibition of cellular proliferation by promoting apoptosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", ...

PMC11461874

Consistently, overexpression of TRAF7 causing reduction of DBP levels (Fig. 4a) shortened the period length of the Bmal1-luc rhythms in cultured NIH3T3 cells (Fig. 5b).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", ...

PMC9429973

Methods: Peripheral blood (PB) and BM samples were collected from healthy individuals (n= 22) and lymphoma patients (n=50).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC11538390

Real-time PCR was performed using SYBR Green qPCR mix (Bio-Rad) in Bio-Rad CFX Connect Real-Time System.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Real-time", "PCR", "was", "performed", ...

PMC11783017

Interleukin 11 receptor alpha (IL11Rα) is highly expressed in OS, especially in high-risk or advanced-stage patients, and its high expression is associated with poor prognosis in OS .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11740907

These results emphasize the possible influence of various therapies on the survival rates of mice with cancer and justify the need for more research on the mechanisms and efficacy of each therapeutic option in this experimental setting.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9503669

The YFP fragments were fused to Nef through its C-terminal tail to maintain N-myristoylation and membrane localization.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "YFP", "fragments", "were", "fused", ...

PMC11648299

Fig. 1Patients with Darier diseases a) Typical V-shaped notch at the free margin of the nail on a patient with Darier disease, b) Patient with Darier disease with acute worsening in his face due to eczema herpeticum, c) Red-scaly itching patches in the neck and face area on a patient with Darier disease, d) Red thick patches at the dorsal side of hand with red-white stripes on nails, e) Yellowish larger warty lesions covering the back of a patient with Darier disease, f) Oily crusted lesions on face, similar to seborrhoeic dermatitis, g-h) Small brown papules with a firm, harsh sandpaper-like texture on the back and neck of a patient with Darier disease, i) Patient with Darier disease who was initially misdiagnosed as having intertriginous eczema.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11300085

Moreover, the results of transwell and cell scratch also indicated that the silencing of CMKLR1 significantly (P < 0.0001) reduced invasion and migration of SK-OV-3 cells with less invading cells than chemerin treatment alone (Figure 4(d), 4(e), and 4(f)).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11127909

These results suggested that EFHD1 could promote mitochondrial functions to protect OS cells from chemotherapy stress.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "results", "suggested", "that", "EFHD1", "coul...

PMC9143157

Regarding the in vivo antitumor activity of P-THP, we adopted the dosage of 5 mg/kg for THP and 15 mg/kg (THP equivalent) for P-THP, because 15 mg/kg is almost the LD50 of free THP, of which 40% of the tumor-bearing mice died at this dose in our previous study , while the LD50 of the P-THP was reported to be higher than 60 mg/kg , and no apparent side effects were found at 15 mg/kg .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC7053076

The transactivation domain is a C-terminal non-homologous domain that is important for NF-κB-mediated gene transactivation.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "transactivation", "domain", "is", "a", "C-terminal", ...

PMC11098378

This mixture was incubated at room temperature for 20 min before adding dropwise to the well and incubating 48 h. The toxicity of the pIB/V5-His-based effector library was measured using a CyQUANT LDH Cytotoxicity assay (Invitrogen; S4 Table).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11765988

The development of HL seems to be the outcome of the interaction of genetics, environmental factors, and the likely impaired immune system.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC7823217

C. GFR Matrigel with formation of 3D acini ™.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "C.", "GFR", "Matrigel", "with", "formation", "of", "3D", "acini", "™", "." ] } ]

PMC10854447

Anal.

[ { "tags": [ "O", "O" ], "tokens": [ "Anal", "." ] } ]

PMC6222726

92 species) .

[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "92", "species", ")", "." ] } ]

PMC10571053

Inhibition of the antiporter leads to depletion of glutathione and inactivation of GPX4.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Inhibition", "of", "the", "antiporter", "leads", "to", "depletion", "of", ...

PMC10870498

p < 0.05 indicates that the difference is statistically significant.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "p", "<", "0.05", "indicates", "that", "the", "difference", "is", "statistically", "significant",...

PMC11766332

Of 64 studied miRNAs differently expressed and identified in at least two studies (ASD-miRNAs), we identified a subset of 25 ASD-miRNAs (39%) associated with glycosylation pathways and reported to be upregulated or downregulated in patients with ASD (Supplementary Table S1).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9559528

Furthermore, syphilis should be considered as a potential precipitating or contributing factor in patients presenting with generalized EM, especially in those with HIV/AIDS.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC7185206

Recombinant Fc-PD-L1 significantly reduced CD8 + T cell survival.10.1080/2162402X.2020.1744980-F0004Figure 4.Tumor-derived sPD-L1 induces activated human CD8 + T cell death and competes with PD-(l)1 inhibitors for effect on CD8 + T cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11271278

Then for every gene, two scores were calculated to account for the number and strength of interactions between a promoter and its enhancers.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC11748618

Using chromatin states, regulatory motifs, and gene expression profiles, we tested the association of these variants in blood tissues from individuals of African ancestry.

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PMC3274243

While the developments described in this publication have enhanced the potential of the technology in such fields, we recognise that further research and development is required to identify the mechanisms by which the OCP is generated and fully validate its efficacy.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Summary/Conclusion: CAMMA 3 is a study of SC cevostamab monotherapy in patients with R/R MM.

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PMC11803149

All statistical analysis were calculated using GraphPad Prism 10.

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PMC5925824

Data are representative of multiple independent experiments.

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PMC6133382

Although modern production technology provides the means to express and purify properly folded recombinant glycoproteins at a large scale, controlling the glycosylation has been a persistent problem for most glycoproteins because of the “non-templated” nature of glycosylation [30–32].

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PMC7305184

Cells from EP group were exposed to pulse treatment) and then transferred to the new growing flask.

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PMC11697189

A, B) The top 20 mutated genes in the high-risk group (A) and low-risk group (B). (

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PMC11656657

Tumor growth was monitored by IVIS imaging until day + 29 post-treatment (day + 155 post-tumor inoculation) (Fig. 4L); we observed a significant tumor regression in all CAR.GD2 T-cells treated mice compared control NT T-cells mice group (Fig. 4M).

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PMC9429973

Fractional abundance of BCL2 mutations identified by NGS was assessed retrospectively in serial peripheral blood samples by ddPCR using custom-designed, allele-specific assays.

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PMC11488203

A breast cancer hybrid cell after spontaneous fusion of MDA-MB-231 with MSC060616 is documented by the white arrowhead (bar = 25 µm) (A).

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PMC11597291

The ζ-potential of the nCGO was highly negative (−50 mV) due to the presence of –COOH groups on the lattice.

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PMC9985266

The immunofluorescence assays showed that either DNMT1 overexpression or MEG3 silencing reversed the promotion of LC3 and Beclin1 fluorescence intensity by IL-27 compared with the IL-27 group (Fig. 6E; Additional file 1: Fig. S9B).

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PMC9024365

Similar to the GluA1 chimeras, we used GluK2/GluA2 chimeras to identify the region sufficient for clustering with SD4.

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PMC9388315

Then agitated for 30 min at 4°C.

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PMC11763111

We believe that CD38 represents a valuable, broadly applicable target, and that a universal CD38-targeting CAR construct holds promise for treating various hematologic malignancies.

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PMC10976516

injected A549 cell line) xenotransplanted NSCLC model, EphA2-TEA-VV was i.v.

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PMC10808409

The anticancer activity of FA and Tocopheryl polyethylene glycol 1000 succinate (TPGS) mixed micelles formula (O2) was assessed by MTT and flow cytometry.

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PMC11092382

However, the toxicity and safety profile of sophocarpine have not been well characterized to date.

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PMC11697703

We confirmed that neurons in the heterotopic clusters have reduced MAPK8 signal compared to non-electroporated nearby/adjacent neurons, as we previously showed in miR-193b and -365 electroporated layer II-III neurons (Figures 3G–3I).

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PMC6600592

Succinic anhydride (1 equiv, 25 mmol) in 30 mL CH2Cl2 reacted with substituted benzenes (1, 25 mmol) under stirring for 0.5 h in ice-water bath, then anhydrous aluminum chloride (37.5 mmol) was added to the CH2Cl2 solution (Scheme 1).

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PMC8540692

A mild increase in the permeability of bisdemethoxycurcumin through the BBB was recorded after using the combination of CCM:NaBu in the ratio 1:1000 (Papp 3.618 × 10 ± 1.963 × 10 cm s).

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PMC9429973

Subgroup analyses were planned.

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PMC7762347

In this regard, a previous study suggested that CYN had a prominent role in the genotoxicity of CYN/MCLR combination by the comet assay, the micronucleus assay and target gene expression on HepG2 cells , but further research was required.

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PMC11746948

Scale bar, 4 μm.

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PMC7189327

Finally, ROC analysis revealed that CYFIP2, HOXB5, PTPN3, MARCKSL1, PTCH1, and CDC20 could distinguish BCC and healthy individuals.

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PMC11759543

The one-way ANOVA with Dunnett's multiple comparisons test was used when appropriate.

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PMC11700523

The 5/6 Nx group in this study showed decreased plasma aldosterone levels compared with the sham group.

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PMC9351137

Scale bar = 10 μm.

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PMC9429973

Proteomic analysis by proximity-dependent Biotin Identification (BioID) was used to assess affinity of mutant Helios to its interaction partners, while single-cell RNA sequencing was applied to peripheral blood mononuclear cells (PBMCs) of two patients to study the transcriptional effect of the truncating and biallelic IKZF2 mutations.

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PMC11769516

Mycotoxins’ neurotoxicity and cytotoxicity have been demonstrated by the impairment of gene expression, cell proliferation and the induction of oxidative stress.

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PMC11568601

To explore the underlying mechanisms, 4-phenylbutyric acid (4-PBA) was selected as a specific endoplasmic reticulum (ER) stress inhibitor.

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PMC9429973

Results: In the first patient, four variants affecting the genes CBL (VAF =7.4%), MPL (50%), JAK2 (51.5%) and ETV6 (10,6%) were detected at diagnosis in BM.

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PMC9429973

Cancer cells catabolize glucose to lactate in aerobic conditions: a sharp time dependent increase in extracellular lactate release was observed in MM cells over time which was suppressed by YKL-5-124 treatment via regulation of lactate dehydrogenase A (LDHA) expression and enzymatic activity.

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PMC9429973

In addition, MF pts with history of thrombocytopenia continued RUX treatment at lower doses compared with those without a history of thrombocytopenia.

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PMC11461874

Statistical analysis of the data was performed with one-way ANOVA with Tukey’s correction.

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PMC10135767

As for the mechanical regulation of cellular calcium signaling, the effect of external force on the calcium bursting of T cells is induced by the TCR-pMHC complex .

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PMC11474209

The mitochondrial abnormalities in the etiology of several human illnesses linked to MC-LR exposure underline the translational relevance of innovative pharmacological treatments targeted at selective mitochondrial engineering, which might open new opportunities for developing novel therapies.

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PMC11683240

α1AT, α1-antitrypsin; PT, pertussis toxin.

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PMC11564322

The c-SRC inhibitor I alone increased the c-SRC kinase protein expression by 14.10%, compared to the control.

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PMC11459296

with 1×10 A673 Ewing sarcoma cells (ATCC).

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PMC11574271

B The IHC analysis revealed distinct staining patterns of RON protein expression in bladder cancer and adjacent normal tissues, with a total of 119 samples analyzed, including 26 normal tissues and 93 bladder cancer tissues.

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PMC9841531

The data was processed using GraphPad Prism version 8.4.0, and IC50 values were determined, applying three- or four-parameter logistic equations, whatever was statistically preferred.

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PMC11806106

Increasing concentrations of nociceptin were applied followed by a saturating concentration of nociceptin.

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PMC11779960

c Alternative mature TCL origin proposed by Thiele et al., derived from immature progenitor cells not committed on TCRβ and displaying polyclonal TCRαβ clonotypes.

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PMC11755519

Tumors rapidly develop a new vascular network to promote a high proliferation rate of tumor cells (Figure 4, Table 2).

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PMC9684669

Gene ontology (GO) enrichment analysis revealed that 13 calcium-related biological pathways were activated in the A2780-ADR cell when compared to its parental A2780 cell. (

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PMC11786704

The results of Masson's trichrome staining and immunohistochemistry staining, including the expression of IL-6, TNF-α, and MnSOD in wound tissue were shown in Fig. 4F.

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PMC11757131

The cells were seeded in six-well plates and treated with different concentrations of 3-HIB (0, 0.2, 0.4, 0.8, and 1.6 mM) for 48 h. After treatment, cell samples were collected using a cell lysis buffer.

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PMC11719944

Immune system activation is essential for pathogen control and disease prevention, but regulatory mechanisms are required to avoid immunopathology caused by overactive immune responses.

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PMC11281366

Site-directed mutagenesis of the 3′ UTR of CD59 was performed via PCR to generate mutations (see Mut (mutation) primers in Table S1) and cloned into pMIR-REPORT-Luc using the same strategy described above.

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PMC9429973

Grade (G) 1 to 2 neuropathy occurred in 19% (5/26) of evaluable patients but did not result in treatment cessation in any case.

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PMC11538390

Briefly, cells were sheared using PIXUL to obtain genomic DNA fragments averaging 300–600 bp.

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PMC7334607

Point-Range Plots Demonstrating EC50 Changes in A673 Experimental and Control Replicates Over Time Bottom: Point-range plots representing the changes in drug response to a panel of nine drugs.

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PMC9429973

The urgent need for the development of tailored treatments requires a better understanding of the effects of NUP98-KDM5A on the deregulation of gene expression programs.

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PMC9985266

However, the underlying mechanism by which IL-27 attenuates PF is not fully clear.

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PMC7802142

Subsequently, the library preparations were sequenced on an Illumina Hiseq 2500 platform and paired-end reads were generated.

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PMC9261184

The figure indicates the cause of some of this variation: the split between CO2 and methane emissions.

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PMC10993311

T test for independent samples.

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PMC10969097

The administration of cisplatin was conducted at concentrations of 40 μM for SKOV3 and 200 μM for SKOV3/DDP, while SBSGL was given at a concentration of 200 μM. Regarding tumour volume and weight, the group that received the combination of cisplatin and SBSGL showed more pronounced inhibitory effects on tumour growth compared to the group that received treatment with cisplatin alone.

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PMC11790971

Plots were generated using Matplotlib (version 3.2.2) and Seaborn (version 0.11.0).

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PMC10728200

Significance denoted by: ns not significant, *P < 0.05, **P < 0.01, and ***P < 0.001.

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PMC9429973

The median age at diagnosis was 54 (aged 21-65).

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PMC6835428

Thus, the development of novel strategies is of the utmost urgency.

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PMC9143157

However, pembrolizumab monotherapy has shown less activity , and chemotherapy using cytotoxic drugs remains the first-line dominant treatment.

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PMC11001582

Peaks correspond to physiological recruitment of motor units following electrical stimulation; n mice = 5 WT, 6 (GR)400 and 6 (PR)400; n muscles = 8 WT, 12 (GR)400 and 9 (PR)400.

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PMC11506670

The signaling cascade commences with the binding of epithelial growth factor (EGF) to EGFR, which sets in motion a sequential activation of downstream effectors, including RAS, RAF, MEK, and ERK.

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PMC11394112

Here, we evaluated DLBCL colonization and expansion in NSG mice expressing human IL3, CSF2, and KITLG with and without human IL6 co-expression and also in IL6-only-expressing NSG mice.

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PMC6684588

The knee was immobilized using a 27 gauge needle inserted through the knee joint and clamped to the platform (Fig. 4) or by a silk suture passed beneath the patellar tendon used to securely fasten the knee against a stationary horizontal rod (Figs. 3, 5).

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PMC10748106

For that reason, an iso-surface of −10 kcal/mol value of MEP was obtained (see Figure 3).

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PMC11218145

with Ren cells.

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PMC10976516

In addition, it became clear that systemic anticancer treatment efficacies of OV platforms derived from measles virus, vesicular stomatitis virus (VSV), reovirus, HSV, adenovirus, and parvovirus are significantly hampered or eliminated by pre-existing or therapy-induced neutralizing antibodies.

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PMC11659921

Our functional analysis revealed that these genes were associated with several biological processes, including cell cycle inhibition, DNA damage response, epithelial‐mesenchymal transition (EMT) activation, androgen receptor inhibition, and RAS/MAPK pathway activation.

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PMC11727062

Additionally, the study elucidated that dihydroartemisinin modulates the differentiation and expansion of immune cells within the tumor microenvironment, including CD8+ cytotoxic T lymphocytes (CTLs), CD4+ T helper cells, and regulatory T cells (Tregs), thereby augmenting the antitumor immune response in mice.

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PMC11704834

The authors are currently performing molecular genetic studies to determine which of these TFs contributes to the elevated TLE1 expression in EGFR-TKI resistant cells.

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PMC9577200

It is essential to mention that a high concentration of GO may be toxic to bacteria, but we want to inhibit bacteria by using low concentrations rather than high concentrations to avoid any damage.

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PMC11628904

At right, representative images show a tailfin pre‐ and post‐burn in the presence of cell impermeable FM dye.

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PMC8526701

In the current study, we investigated the correlation between the expression of BRD9 and the inhibition of cellular proliferation by promoting apoptosis.

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