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OTAR3088
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BioData-CellLine_annotated

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PMC9429973
Relapsed/refractory MM (r/r MM) is associated with particularly poor prognosis.
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PMC10759659
Therefore, we assessed whether the expression of galectin-9 could be upregulated in ARID1A knockout HCC cells.
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PMC11770130
Together, these data suggested that NTS-NTSR2 signaling regulated the C20–C24 ceramide synthesis, which affected the production of GDF15 and food intake in mice.
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PMC11718809
All experiments were conducted in accordance with the Guidelines for the Care and Use of Laboratory Animals (Approval No. 2006-398) formulated by the Ministry of Science and Technology, PRC.
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PMC11248911
The samples were analyzed by fluorescence-activated cell sorting (FACS) with a Gallios flow cytometer (Beckman Coulter, Brea, CA, USA) within 1 h after staining.
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PMC9429973
Thirty-eight (48.1%) died during follow-up (median 34 months; range 0-184).
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PMC10719213
All of the 11.1 kb amplicons passed the quality control for library generation.
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PMC11742431
Therefore, achieving targeted degradation in specific cells remains a considerable challenge. ,
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PMC9351137
A Histograms showing the quantitative analysis of cell division defects.
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PMC9436459
Mulberrofuran G (31), albanol B (46), and kuwanon G (92) displayed potent inhibitory activities against ChEs and β-site amyloid precursor protein cleaving enzyme 1 (BACE1) .
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PMC3931643
b. Propidium iodide staining to measure the percentage of cells with sub-diploid DNA content in the VAL cells expressing 4EBP1 upon treatment with 100 nM MLN0128 with and without doxycycline induction.
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PMC11544122
HEK293 cells deleted of SNX9 were transfected with LentiCRISPRv2 backbone that contained Cas9 gene and sgRNA against SNX9 with Lipofectamine 2000.
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PMC9014716
Zhao et al. found that miR-491-3p can inhibit the expression of ABCB1 at both the post-transcriptional and transcriptional levels.
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PMC10898159
In the setting of second and beyond, sunitinib had better inhibitory effect on KIT mutants with exon 9 or 11/13 or 14 double mutations than IM, but regorafenib, dasatinib, nilotinib and sorafenib was largely effective to inhibit the phosphorylation of KIT with secondary exon 17 mutation [217–219].
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PMC9429973
A single dose of 200 x10 CD19 CAR T-cells is delivered to patients with B-NHL.
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PMC10812665
Such approaches, called read-across strategies , may not always be feasible, but this situation is going to change as more data become available on a broad range of compounds (e.g., by large-scale screening programs).
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PMC11754094
Using an established method to increase pegRNA stability, we introduced PE3 with the engineered pegRNA (epegRNA) and found that this resulted in an increase in large-deletion frequencies (Fig. 5c).
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PMC8916024
Among the 6,233 OTUs, 1,452 (23.3%) were shared by three groups, and 434 (7.0%), 355 (5.7%), and 2,785 (44.7%) were unique in the adult and juvenile snail guts, and the sediment samples, respectively (Fig. 1A).
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PMC11719944
To determine serum concentrations, the samples were analyzed on an MACS Quant X cytometer (Myltenyi Biotech, Santa Barbara, CA, USA).
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PMC5415764
However, the frequent occurrence of multidrug resistance (MDR) is a common obstacle to effective chemotherapy, leading to chemotherapy failure in the majority of ovarian cancer patients.
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PMC10631132
A, D Undifferentiated iPSCs were used as a reference for marker expression.
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PMC9429973
As in patients, HPC-BCR/ABL cells show partial IM resistance and leads to the enrichment of undifferentiated LSK cells.
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PMC11789597
A circular heatmap representing the mRNA expression of NK‐related inhibitory or stimulatory molecules in MM cells expressing shNC or shCAV1.
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PMC11537649
Collectively, our findings might provide new information on melanoma treatment.
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PMC9065483
Using opaque white bottom 96-well microplates (Thermo Fisher, cat.
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PMC11543885
Note: In terms of epitope tagging, V5 and flag have been successfully used for APEX2 fusion proteins.
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PMC6600253
In pemetrexed-based chemotherapy, dexamethasone is co-administered to alleviate severe drug-induced and painful skin rashes .
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PMC10142392
Whereas solvophilic parts maximize their contact with solvent molecules, solvophobic parts minimize this contact.
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PMC11748363
Related to 1/MIC.
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PMC6835428
Due to their mechanism of action, siRNAs are particularly suited to targeting gene products of which the exuberant expression is responsible for increased cell growth, cell survival, migration, angiogenesis, and drug resistance (Table 2, Table 3 and Table 4).
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PMC11621493
Five hundred microliters of the TALON metal affinity resin (635501, Takara Bio, Kusatsu, Japan) were equilibrated by resuspending the beads in 10 ml of binding buffer twice.
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PMC9429973
Relative risks (RR) for DR, complete remission (CR) rates, and 30- and 90-day mortality were modeled, and OS and relapse-free-survival (RFS) were calculated and compared using the 5-year restricted mean survival time difference (Δ5y-RMST).
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PMC11773391
A strategy targeting the MEK–ERK–MDM2–p53 pathway combined with TMZ may be a novel and promising treatment for glioblastoma .
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PMC7570809
Here we demonstrated the ability of the peptide to diminish both adhesion and invasion of HepG2 cells, an in vitro model system for hepatocellular carcinoma, to reduce the cell proliferation through an apoptotic process, and to interfere with the PI3K pathway.
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PMC5025404
At the first step, the combination of selected genetic constructs was transfected into CHO-DG44 cells.
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PMC11653533
respiratory tract infections such as asthma, bronchitis, tuberculosis and emphysema(Bafor and Igbinuwen, 2009)chest pain(Bafor and Igbinuwen, 2009)Diarrhea(Mouho et al., 2018)to treat furred tongue, tonsillar, throat inflammation,(Chhabra et al., 1984)Plant tissueorms, hemorrhoids, unusual extension of the spleen and to relieve hackRootbarkasthmaViscid non-milky saptreatment of eye troubles and stomach torment(Bafor and Igbinuwen, 2009)to stop bleedingSteam barktreat wounds, boils and burns)Ficus microcarpadried leaves, airborne, roots, and barkcontrolling sweat, easing fever, calming torment, treat flu, jungle fever, intense enteritis, tonsillitis, bronchitis, rheumatism and type-2 diabetes(Chiang Chan et al., 2017)Leaves and fruitsallergic conditions, nausea and skin itching(Wangpan et al., 2019)Leaves, ethereal roots, and barkdecreasing fever, soothing pain, and the treatment of liver maladies(Rjeibi et al., 2017)Barkused in ulcers, burning sensation, hemorrhages, leprosy, itching, toothache(Gunasekaran and Balasubramanian, 2012)used to treat diabetes and liver malady(Nair and Mahesh, 2016;5(5):102.)to reduce fever and dysentery(Padal et al., 2013)Ficus racemosaBark, fruits, leaves, roots, latex and seedsutilized in disorders like diabetes, liver disorders, loose bowels, inflammatory conditions, hemorrhoids, respiratory and urinary maladies(Deep et al., 2013)Leavesutilized to treat wounds, ulcer, dysentery, loose bowels, bilious infection(Mandal et al., 2000)Barkcondition like threatened premature birth, urological disorders, diabetes, hiccough, leprosy, diarrhea, heaps and ulce(Deep et al., 2013)wounds, and in treatment of asthma, heaps and menorrhagia(Ferdous et al., 2008)Rootnflammatory glandular extensions, hydrophobia, mumps, loose bowels, pectoral complaints and diabetes(Gunasekaran and Balasubramanian, 2012)Latexhemorrhoids, the runs, diabetes, bubbles, traumatic swelling, toothache and vaginal maladies(Deep et al., 2013)Bark and leavesutilized in diarrhea, menorrhagia, compelling remedy in glandular swelling, boil, persistent wounds, cervical adenitis and hemoptysisFicus religiosaWhole plantasthma, hack, gonorrhea, loose bowels, dysentery, vermicide, ulcers, leucorrhea, molar torment, cardiac issue, menorrhagia, vaginal and other urogenital disorders,(Akhtar and Begum, 2009)hemorrhoids and a few central nervous systems (CNS) disorders, including epilepsy(Singh et al., 2012)Rootsexual disorders, arthritis, elephantiasis, stomatitis, leprosy, malarial fever, respiratory maladies, chicken pox, epilepsy, burns and wounds.(Khan et al., 2011)Barkutilized as astringent, love potion, antibacterial, anmd to treat gonorrhea, loose bowels, dysentery, hemorrhoids, gastrohelcosis, inflammation, burns, scabies, hiccup and heaving(Makhija et al., 2010)Leavesutilized in asthma, cough, sexual disorders, the runs, haematuria, toothache, migraine, eye troubles, gastric issues, scabies, tuberculosis, fever, loss of motion and hemorrhoidsFruitsasthma, purgative, digestive, tuberculosis, fever, paralysis and hemorrhoidLatexused in neuralgia, inflammations and hemorrhagesFicus sycomoruscough, loose bowels, skin infections, stomach disorders, liver malady, epilepsy, tuberculosis, lactation disorders, helminthiasis, barrenness, sterility and diabetes mellitus(Dluya et al., 2015)Steam barktreatment of sore throat, scrofula, respiratory and chest maladies,(Maregesi et al., 2007)to treat sore, boils, peptic ulcers, jaundice, vaginal or butt-centric and fungal infections of gut(Erhirhie et al., 2018)gastrointestinal tract issues, diabetic complications, infertility, low sperm count, human sterility, breast milk production, excessive menstrual and sometimes in treatment of cancer(Dluya et al., 2015)Leavesin jaundice and as an antidote for snakebite(Maregesi et al., 2007)Fruitsused in stomach pain and tuberculosisWhole plantin respiratory disorders and certain skin diseases(Erhirhie et al., 2018) Ethnophramacological utilization of different species of Ficus genus.
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PMC5963610
The functional impact of such CD8T cell response, in the selection of tumor resistant variants of 3LLD12-cells, has been extensively studied .
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PMC10926885
We conducted a study using the TISMO database to determine whether the expression level of NDE1 has an effect on tumour immunotherapy.
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PMC11544122
Therefore, it is possible that SNX9 and β-arrestin recognition sites on CXCR4 are non-overlapping based on their ability to discriminate between different receptor phosphorylation states.
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PMC11759751
The killing ability of CD19 CAR T cells against three B-NHL cells in vitro under different effect target ratio (C) To investigate whether chidamide could improve the product function of CD19 CAR T cells, we transfected T cells with lentivirus with CD19 CAR on the second day, followed immediately by different concentrations chidamide (0.001 μM, 0.01 μM, 0.1 μM and 1 μM) (Fig. 2A).
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PMC11457557
Recently, using Mendelian Randomization (MR) methods, it was demonstrated the causal relationship between gut microbiome and microvascular complications in T2DM, providing a new strategy for the prevention and treatment of T2DM .
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PMC11502327
We reviewed the mechanism of action of natural drugs against OC, reviewed the morphological composition and delivery potential of drug nanocarriers based on the application of nanotechnology in the treatment of OC, and discussed the limitations of current NNDDS research.
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PMC10006224
Here we have examined the effect of reducing NIPBL levels on the behavior of the two cohesin variants carrying STAG1 or STAG2 by combining a flow cytometry assay to measure chromatin-bound cohesin with analyses of its genome-wide distribution and genome contacts.
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PMC11533140
First, the targeted compounds were assayed for their inhibitory activity against PI3Kα, and compounds with good inhibitory activity were further evaluated for their antiproliferative activity against A2780, U87MG, MCF7, and DU145 cancer cells, overexpressing PI3K, using BKM-120 as the positive control.
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PMC11412752
We found that STING knockout cells are more susceptible to Salmonella infection, with increased bacterial growth.
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PMC11753435
Protein concentration was quantified using the Pierce BCA Protein Assay Kit (Thermo Fisher Scientific, 23225).
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PMC11745600
The short-term transplantation of hSC β cells into Ins1 NOG mice.
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PMC11271278
Prostate cancer cell lines LNCaP, MDAPCA2B, 22Rv1, and VCaP, ERα-positive breast cancer cell lines ZR751 and MCF7, lymphoma cell lines REC1 and DOHH2, lung squamous cell line NCIH2170, and small cell lung cancer cell lines NCIH446 and NCIH1876 were obtained from the Cancer Cell Line Encyclopedia (CCLE).
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PMC11672142
Its cytotoxicity (IC50 0.77 ± 0.06 μM) is superior to that of unconjugated Def and Trp ligands (IC50 2.6 ± 0.15 μM and 1.1 ± 0.04 μM, respectively) in single-compound and combination treatments and is selective toward cancer cells.
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PMC6034753
Here, we report for the first time that Meq protein can physically interact with apoptin protein, with potential functional significance.
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PMC11300639
Given that CDK4/6 inhibitors regulate the stability of TSC1 (Fig. 1) and that CDK4-mediated phosphorylation of RNF26 promotes RNF26 binding with TSC1 in ccRCC cells (Fig. 2), we showed that knockdown of RNF26 diminished the TSC1 protein level change induced by overexpression/knockdown of CDK4 or treatment with CDK4/6 inhibitors in 786-O and A498 cells (Fig. 6m, Supplementary Fig. 3a, b).
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PMC9429973
In addition, various biomarker studies are planned to investigate the differential mode of action of Anbal-cel during phase 2 study.
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PMC11792766
Food simulant E, PPPO, is in the form of an insoluble powder, and, as such, it does not allow for the homogeneous dissolution in exposure medium.
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PMC11629192
Serum anti-NMDAR antibody was negative.
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PMC11796104
BP, biological process; B) CC, cellular component; C) MF, molecular function; D) KEGG pathways Significantly enriched GO terms and KEGG pathways of common gene found in host genes and DEmRNAs.
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PMC11680562
The distribution of particle size of CuO NPs Morphology of the CuO NPs through TEM (a) CuO NPs in lower resolution (scale 200 nm); (b) CuO NPs in higher resolution focussing on single NPs (Scale 20 nm); (c) CuO NPs in higher resolution focussing on single NPs surface along with SEAD pattern; (d) the elemental analysis of CuO NPs through EDX. (
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PMC10723784
The results correlated with greater cytotoxic effects of CBD and CBG on cisplatin‐sensitive cells compared to cisplatin‐resistant cells.
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PMC7553912
The mRNA expressions of OPN, ANXA1, and ANXA2 were increased by stimulation with OSM in both RTECs (Fig. 7b) and renal fibroblasts (Fig. 7c).
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PMC11775197
Can PPAR expression levels be used as a screening and prognostic indicator for CRC and indicate patient condition?
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PMC11551844
The common pathway for AuNPs with functionalized, charged or neutral charge is by clathrin-mediated endocytosis (i.e. binding of AuNPs to specific receptors on the surface of the cells).
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PMC11461833
The data were normalized to -Actin. (
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PMC9429973
The role of TP53 in prognosis of MF has long been unclear, but recent first studies suggested worse survival for patients harboring this mutation.
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PMC8097906
The red underlined concentrations of VSM, Geni, LW and Jaspl.
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PMC5415764
Finally, each sample was analyzed by using a flow cytometer (BD Biosciences, California, USA).
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PMC11406030
Total body weight, liver and spleen weight, and general mouse behavior were monitored during treatment.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Total", "body", "weight", ",", "liver", "an...
PMC7757104
Statistical analysis was performed using Microsoft Excel 2010 (Microsoft Corporation).
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PMC11388384
Without such understanding, it is impossible to understand how physical and evolutionary constraints affect animal morphogenesis.
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PMC11519583
To examine the proportion of Ki-67-positive MPs, MPs were transfected with the indicated siRNAs (siRNA sequences are listed in Supplementary Table 2) and cultured in DMEM containing 10% (v/v) FBS for 3 days.
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PMC11711871
Fig. 1GR rats presented adrenal hyperplasia of the cortex and the medulla accompanied by a trend toward an increase in the plasma glucocorticoid concentration under standard diet.
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PMC11085211
Analogously, although with faster kinetics, an increase in early and late apoptotic cells was also observed in GIST-T1 after 6 h of treatment (Figure 2—lower panel).
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PMC11301095
A 45-day comprehensive treatment regimen was administered, encompassing anti-amebic medications, anticonvulsant therapy, management of brain edema, and intracranial pressure reduction.
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PMC11708541
Yet there is no cure for multiple sclerosis.
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PMC11451829
After the procedure, postoperative antibiotic-corticosteroid eye drops (dexamethasone 1 mg/mL + tobramycin 3 mg/mL, Sophia) were administered three times daily for 1 day.
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PMC4659567
The crystal data and structure refinements are given in S1 Table.
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PMC9429973
34 PPGV carriers had serial NGS tests available (range 2-5 reports); in these patients, VAF standard deviation across serial measurements was <5% in 89% of cases.
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PMC11726848
LDR irradiation was performed at doses of 12 Gy (LD50 MTT assay) and 36 Gy (>D37 MTT assay).
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PMC11803918
After three freeze–thaw cycles, the mixture was diluted in the flow buffer and run under NovoCyte Quanteon (Agilent) following the manufacturer’s protocol.
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PMC11285179
C Diagram of the metabolic conversion process in the retinoic acid metabolic signaling pathway.
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PMC11578343
Notches in the boxplots represent the 95% confidence interval of the median.
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PMC11787381
Control: white.
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PMC11723947
a Representative dot-plots showing 21 days after engraftment the percentage of WT and HP1α KO TCR Vβ6CD4 T cells producing IFN-γ and IL-17A.
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PMC11541241
Abbreviations: At, Arabidopsis thaliana; Bc, Botrytis cinerea; Bgt, Blumeria graminis f. sp. tritici; Cg, Colletotrichum graminicola; Fg, Fusarium graminearum; Fo, Fusarium oxysporum; Hs, Homo sapiens; Mo, Magnaporthe oryzae; Pi, Phytophthora infestans; Pst, Puccinia striiformis f. sp. tritici; Sc, Saccharomyces cerevisiae; Sp, Schizosaccharomyces pombe; Um, Ustilago maydis; Vd, Verticillium dahliae.
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PMC10723784
Figure 5 shows the effects of cannabinoids in inducing apoptotic cells in both A2780 and A2780/CP70 cells.
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PMC11626627
The tumor weight of each group was measured in situ within 4 weeks after injection.
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PMC11790599
This phenomenon can also be explained that chronic or excessive NRF2 activation may interfere with normal metabolic pathways (He et al., 2020), including those related to lysosomal biogenesis and functional maintenance (Kim et al., 2024; Ong et al., 2023), indirectly affecting lysosomal activity.
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PMC8524093
Epithelial fibroblast is also an interesting primary cell line to evaluate first steps of CHIKV infection and the mechanisms that trigger cartilage damage (Ekchariyawat et al., 2015).
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PMC9429973
Ž. Antić, P. Chouvarine, J. Lentes, C. Schröder, J. Alten, A. Möricke, M. Brüggemann, E. Carrillo-de Santa Pau, T. Illig, T. Laguna, D. M. Schewe, M. Stanulla, M. Tang, M. Zimmermann, M. Schrappe, B. Schlegelberger, G. Cario, A. K. Bergmann Institute of Human Genetics, Hannover Medical School, Hannover; Berlin-Frankfurt-Münster ALL Study Group Germany (BFM-G), Department of Pediatrics; Department of Hematology, University Medical Center Schleswig-Holstein, Campus Kiel, Kiel, Germany; Computational Biology Group, Precision Nutrition and Cancer Research Program, IMDEA Food Institute, Madrid, Spain; University Children’s Hospital, Medical Faculty, Otto-von-Guericke-University-Magdeburg, Magdeburg; Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany Background: B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is the most common childhood malignancy.
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PMC9429973
We are therefore currently extending our research to investigate the effects of nutritional cues on HSCs, and the metabolic changes that are critical to mount appropriate stress responses.
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PMC6684588
Weight of injected gastrocnemius muscle after ACE-083 treatment compared to uninjected, contralateral gastrocnemius.
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PMC9429973
In the phase 1b TRIMM-2 study (NCT04108195), teclistamab plus daratumumab (tec-dara) provided promising efficacy and was also well tolerated.
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PMC9429973
The survival without switching was similar for patients on imatinib, dasatinib or nilotinib in first line as in second line.
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PMC11483468
Therefore, combining TAT-LPTS39 polypeptide with other drugs can be considered to improving anticancer activity.
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PMC7553912
WT and OSMRβ mice were given intraperitoneal injection of GOx (80 mg/kg) once daily for three or six days. (
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PMC11643361
Further studies were conducted to assess the metabolic stability and protein interactions of complexes 66 and 69.
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PMC2196094
The results show multiple bands in the size range of 3–20 kb after cleavage with Bam HI, BglII, or EcoRI.
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PMC11539788
The qRT‒PCR assay was conducted on a LightCycler96 using SYBR qPCR SuperMix Plus (Novo Protein: Shanghai, China).
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PMC9429973
Summary/Conclusion: The is the largest retrospective analysis of real-world clinical practice outside of a clinical trial in BPDCN pts treated with TAG.
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PMC11297139
Scale bars: 5 μm.
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PMC11700340
This kinase is a considerably preserved serine-threonine protein kinase categorized as a constituent of the Aurora family and has a crucial role in regulating mitosis , Aurora kinase B is raised in pleomorphic gliomas, malignant mesothelioma, and hematological malignancies.
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PMC11733919
The black product was dissolved in hexane, precipitated with ethanol, and magnetically separated again.
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