OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC11347429	DEGs and their known functions.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "DEGs", "and", "their", "known", "functions", "." ] } ]
PMC11429241	Also, there were some minor deviations from the 3D models overall in a range of up to 10 m. This can be explained by the substantially lower viscosity of PEGDA (0.101 ± 0.03 Pa·s for PEGDA vs. 1.5 ± 0.3 Pa·s for OrmoClear ), allowing a lot more motion of the material in the vat during printing.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC3675084	Immunofluorescence staining shows the appearance of giant, multinucleated cells (Figure 4) following BPR0L075 treatment of the resistant cells, suggesting that chromosome segregation do occur at least to some extent in paclitaxel-resistant cells but cytokinesis failed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10329237	The cell lysates were combined with an equivalent volume of 2X Laemmli sample buffer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cell", "lysates", "were", "combined", "with", "an", "equi...
PMC11546117	A sample was taken from each dosing solution.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "sample", "was", "taken", "from", "each", "dosing", "solution", "." ] } ]
PMC11683240	Figure 13α1AT levels correlate with B. pertussis infection and leukocytosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Figure", "13α1AT", "levels", "correlate", "with", "B.", "pertussis", "infection", "and", "leukoc...
PMC9429973	Image: Summary/Conclusion: With limitations characteristic to any retrospective analysis, this real-life study demonstrated similar ORR in patients treated in first relapse with DRD or KRD,shorter time to best response with KRD but longer PFS with DRD.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	He was started on romiplostim, that was escalated weekly (Figure solid curves).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "He", "was", "started", "on", "romiplostim", ",", "that", ...
PMC11264242	As a specificity control, we examined the same FYN gene locus by ChIP-qPCR using the non-immune IgG antibody, but no signal was apparently enriched in the IgG-purified DNA product (Figure 2B, white bars).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11790599	Images were visualized through DAPI and FITC filters of fluorescence inverted microscope (Leica DM2500 Fluorescence Microscope) at 20 × objective.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Images", "we...
PMC11519788	The sustained STAT3 activation has been linked to the acquisition of CSC properties and the promotion of carcinogen-induced UBC progression 9,40.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "sustained", ...
PMC9024365	Transfection was performed with 2 μg of DNA using Lipofectamine 2000 (Invitrogen).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Transfection", "was", "performed", "with", "2", "μg", "of", "DNA...
PMC10728200	All samples were normalized based on their protein content.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "samples", "were", "normalized", "based", "on", "their", "protein", "content", "." ] } ]
PMC11277157	It is known that siRNA delivery reagents may induce stress in the subjected cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "is", "known", "that", "siRNA", "delivery", "reagents", "ma...
PMC11568601	Utilizing an EZ-press RNA Purification Kit (EZBioscience, Roseville, USA), total RNA was extracted following the producer’s protocol.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Utilizi...
PMC11509224	The literature has reported 138 bioactivity data entries for these compounds, with 17, 4, and 1 compounds exhibiting two, three, and four different types of bioactivities, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10976516	OVs as a platform for transgene delivery.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "OVs", "as", "a", "platform", "for", "transgene", "delivery", "." ] } ]
PMC11271278	D HiChIP, H3K27ac ChIP-seq (derived from HiChIP reads), and copy number profiles at DNA segments of the MYC ecDNA in NCIH2170 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", ...
PMC11190062	For analyses of TLR expression in primary myeloma cells from patients, RNA sequencing data from CD138 cells (MMRF_CoMMpass_IA14a_E74GTF_Salmon_Gene_Counts) were downloaded from the Multiple Myeloma Research Foundation CoMMpass IA14 release (https://research.themmrf.org/).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5535901	TRIzol, AffinityScript Multiple Temperature cDNA Synthesis kit, and TaqMan real-time PCR primers and probes were obtained from Life Technologies/ThermoFisher Scientific (Waltham, MA, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Results: As of 27 SEP 2021, 15 pts received PV and 10 pts received PVR.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", ":", "As", "of", "27", "SEP", ...
PMC11495567	These were then exposed to blocking buffer (1% BSA) solution for 30 mins on a shaker.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "were", "then", "exposed"...
PMC11225860	The ploidy classification performed by QuPath highlights normalploid cells in green and polyploid cells in blue (C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "ploidy", "classification", ...
PMC8164677	Figure 6Illustrates E-values (Kcal/mol) of best docked poses of wedelolactone and standard drugs with hepatocyte growth factor receptor (cMET), checkpoint kinase 1 (Chk1), ecto-5′-nucleotidase (CD73), mammalian target of rapamycin (mTOR1), nuclear factor erythroid 2–related factor 2 (Nrf2), hypoxia-inducible factor 2-alpha (HIF2α), with heat shock protein 60 (HSP60), insulin-like growth factor (IGF1), P300/CBP-associated factor (PCAF), bromodomain protein 1 (Brd1) and acetyl transferase tip (AT tip60).Figure 7Shows 2D best pose of (A) hepatocyte growth factor receptor (cMET) with wedelolactone; (B) hepatocyte growth factor receptor (cMET) with crozotinib; (C) checkpoint kinase 1 (Chk1) with wedelolactone; (D) checkpoint kinase 1 (Chk1) with anacardic acid.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11574271	E Transfection of 5637-shRON cells with a HIF-2α plasmid and J82-oeRON cells with HIF-2α-targeting siRNA was performed, followed by western blot analysis to assess the expression levels of HIF-2α and MMP12.	[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC8540611	When cells with complexes are incubated for a longer time, those that have undergone apoptosis will already have been destroyed, and the number of cells in which the necessary gene silencing process has not occurred will increase due to proliferation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC3675084	At present, few conventional anticancer treatments can overcome multidrug resistance by inducing cell death via mitotic catastrophe.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "At", "present", ",", "few", "conventio...
PMC11723947	P values were calculated using multiple unpaired t test with Holm-Šidák correction.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "P", "values", "were", "calculated", "using", "multiple", "unpaired", "t", "test"...
PMC11680578	The current treatment for ovarian cancer typically involves a combination of surgery and the use of drugs such as platinum-based cytotoxic agents, anti-angiogenic drugs, etc.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10976516	Other studies investigated the use of DCs as delivery vectors for OV.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Other", "studies", "investigated", "the", "use", "of", "DCs", "as", "delivery", ...
PMC8348645	The appearance of red colour in the lower layer of chloroform indicates the presence of steroids.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "appearance", "of", "red", "colour", "in", ...
PMC9429973	Treatment discontinuation occurred in 17pts (36%) – most commonly due to toxicity (n=8; 17%) and lack of efficacy (n=4; 8.5%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10587429	Experimental timeline showing that the non-humanized mice were injected with luciferase expressing A673 cells orthotopically into the tibia and the tumor bearing mice were treated with control IgG or magrolimab (MAG) (100 ug/animal, i.p.)	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11755519	In addition, the exosomes tested promoted the proliferation of normal fibroblasts in in vitro culture.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", ",", "the", "exosomes", "tested", ...
PMC11655498	Additionally, as a transcription activator, SM binds to and recruits cellular XPB (xeroderma pigmentosum group B-complementing protein, a subunit of TFII H), subsequently targeting the promoters of late genes (Verma et al., 2020).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10582049	Interestingly, we did not observe a significant difference in proportion between FAPACTA2 and CTHRC1FAP CAFs in the indolent and aggressive groups.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Interestingly", ...
PMC11389534	Functional regulation of UFMylation in innate immunity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Functional", "regulation", "of", "UFMylation", "in", "innate", "immunity", "." ] } ]
PMC11591794	In NucBlue staining, GA IC50 and DOX IC50 doses were determined to suppress cell proliferation and thus cause a decrease in cell number.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11714165	This co‐assembled fluorous‐tagged peptide nanoplatform provides a promising approach for developing the next generation of peptide‐based nanomedicines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "co‐assembled", "fluorous‐tagged", "peptide", ...
PMC11468365	For the metric, MultiComb outperforms DeepDSC by + 0.04, MatchMaker by + 0.03%, and DeepDSC by + 0.02.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "the",...
PMC11697189	N-O) Transwell migration and invasion were evaluated in the A498 cells (P-Q) Transwell migration and invasion were evaluated in the ORCS2 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "...
PMC9424261	Data were analyzed using Student’s t test and expressed as mean ± SD from three independent experiments. **	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "were", "analyzed", ...
PMC11750712	ICANS were graded according to grading criteria by ref. .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ICANS", "were", "graded", "according", "to", "grading", "criteria", "by", "ref", ".", "." ...
PMC11786704	Six-week-old male rats (C57BL/6, weighted about 20 g) were intraperitoneally injected with 100 mg/kg streptozotocin (STZ, Sigma-Aldrich) for seven consecutive days.	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10092581	Both Au(I) and Ag(I) complexes were markedly effective, without significant differences, in terms of antiproliferative activity and cellular redox state alterations, thus suggesting that the selenourea moiety plays a key role in cancer cell response to metal complexes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11697065	Map9 has been associated with chromosomal instability , whereas Tmem39b has been described as a cell proliferation regulator.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Map9", "has", "been", "associated", "w...
PMC11742047	The Lipid Annotator method was set as follows: ion species [M + H], [M + Na], and [M + NH4] for positive ESI mode; [M-H], [M + COOH], and [M + CH3COOH-H] for negative ESI mode.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11634794	The stable transfection strains were selected using purinomycin at a concentration of 2μg/ml (Sigma-Aldrich, St. Louis, MO, USA), which based on our previous experiments which found that 2μg/ml of puromycin can effectively kill non-transfected cells while allowing transfected cells to survive and proliferate.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10507284	Ranked dots and scatter plots showing the TROAP‐derived risk score distribution and patient survival statuses (n = 263). (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Ranked", "dots", ...
PMC11420784	The arrow indicates NDP52+ bacteria, and the square frame indicates NDP52 granules.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "arrow", "indicates", "NDP52", "+", "bacteria", ",", "and"...
PMC9429973	Typically diagnosed in childhood, β-thalassemia is marked by the inability to produce hemoglobin, which results in chronic anemia.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Typically", "diagnosed", "in...
PMC10048572	Oshima et al. studied paired tumor samples at the onset and recurrence of childhood ALL using whole exome and whole genome sequencing.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Oshima", "et...
PMC10578720	NF-κB P65 reportedly inhibits PGC-1α function and PGC-1α target gene transcription through protein-protein interactions, while SIRT3 functions as one of the downstream target genes of PGC-1α.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11247842	SCS from Holstein and Jersey phenotypes were DRP derived from a test-day evaluation model.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "SCS", "from", "Holstein", "and", "Jersey", "phenotypes", "were", ...
PMC7039683	We engineered a 606 bp element within IRF6-9.7 into the GFP reporter vector and injected it into wild-type embryos.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "engineered", ...
PMC6133382	Thus, differences in glycosylation between the vaccine immunogens from the RV144 trial and virus particles could, in part, explain the low efficacy of RV144 and other gp120-based vaccines and their inability to elicit bN-mAbs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11765988	M2 (“healer”) macrophages (CD163+) produce anti-inflammatory cytokines, such as IL-4, IL-10, and TGF-β, to modulate the inflammation and protect the organism .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11806106	Cells were tested on a regular basis for mycoplasma.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "tested", "on", "a", "regular", "basis", "for", "mycoplasma", "." ] } ]
PMC11772585	We initially found that the protein levels of METTL1 in the tumor tissues originating from METTL1-knockdown cells were significantly decreased than those originating from control cells (Supplementary Fig. S3A, B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7642379	Non-significant genes have gray bars.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Non-significant", "genes", "have", "gray", "bars", "." ] } ]
PMC11483468	With the forced exogenous expression of the LPTS/PinX1 gene in cancer cells, such as hepatocellular carcinoma (HCC) and urothelial carcinoma of the bladder cells, cellular telomerase activity and cells proliferation were inhibited in vitro and in vivo (10,21).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6889484	Replication kinetics from duplicate flasks are indicated. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Replication", "kinetics", "from", "duplicate", "flasks", "are", "indicated", ".", "(" ] } ]
PMC11040965	Data from real-time PCR and the 2 method, normalized to RNU44 (miR29b) and GAPDH (DNMT3B) and expressed as fold change relative to the average value for plasma cells from 10 controls (patients with benign hematological diseases).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Overall response rate (ORR) was estimated by both response definitions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Overall", "response", "rate", "(", "ORR", ")", "was", "estimated", "by", "...
PMC11252553	The percentages of apoptosis were higher at 48 hours compared to 72 hours post-irradiation (71.96, 66.77, and 62.73% for 48 hours, and 50.69, 42.92, and 45.85% for 72 hours post-irradiation at 4, 8, & 12 Gy, respectively).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7057940	Finally, the slides were evaluated using the G-banding protocol (20).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Finally", ",", "the", "slides", "were", "evaluated", "using", "the", ...
PMC11683240	FCS, fetal calf serum; Gαi, α-subunit of inhibitory G protein.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "FCS", ",", "fetal", "calf", "serum", ";", "Gαi", ",", "α-subunit", ...
PMC11711935	In melanocytes, sFRP2 acts as a melanogenic stimulator through β‐catenin signaling leading to the up‐regulation of MITF and TYR .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "melanocytes", ",", ...
PMC9429973	Death was principally attributable to COVID-19 in 58 patients (69.0%) and contributable by COVID-19 in 15 (17.9%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Death",...
PMC9429973	The median number of cycles to response was 1[1-4].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "median", "number", "of", "cycles", "to", "response", "was", "1[1", ...
PMC10158546	We found ReN cells within these thin 3D cultures to self-arrange into spheroid-like clusters of cells (Figure 1c), similar to 3D neurospheroids produced by culturing ReN cells in low-attachment round-bottomed plates or microwell chips .	[ { "tags": [ "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Bone marrow samples were collected at screening and C2D15 for immunohistochemistry.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Bone", "marrow", "samples", "were", "collected", "at", "screening", "and", "C2D15", "...
PMC10142392	The AB2-type miktoarm copolymer (PEG-PCL2) was synthesized using a "core-first" strategy, which involves functionalizing the end of the mPEG chain, leading to the formation of two initiation centers on the mPEG macroinitiator for PCL arm growth.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Treatment groups were comparable by sex and race.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Treatment", "groups", "were", "comparable", "by", "sex", "and", "race", "." ] } ]
PMC6182045	The efficiency of the recovery process for the purification of TZ97008-rgp120 produced in CHO-S cells and MGAT1- CHO cells were compared.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "B-CellLine", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC10877303	Preliminary, the first drug candidate, Kihadanin B expressed six interactions with 3CL where one Pi-Alkyl bond at HIE194, two Conventional Hydrogen bonds at GLU169, and GLY146, and three Carbon Hydrogen bonds at MET168, HIS166, and CYS145 was observed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	С. 63-68].	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "С.", "63", "-", "68", "]", "." ] } ]
PMC8633974	Although concurrent viral elimination strategies that include broadly neutralizing antibodies (bnAbs) , immune modulation , and chimeric antigen receptor (CAR)-T cells show promise in mice, selection for bnAb resistant strains , viral rebound , and adverse side effects have been reported in monkeys and humans.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	E. Uppal, A. Otamas, J. Khwaja, H. McCarthy, J. Kothari, A. Rismani, D. El-Sharkawi, C. Kyriakou, S. D’Sa Department of Haematology, University College London Hospitals NHS Foundation Trust, London; Department of Haematology, Royal Bournemouth Hospital, Bournemouth; Department of Haematology, Oxford University Hospitals NHS Foundation Trust, Oxford; Department of Haematology, The Royal Marsden Hospital NHS Foundation Trust, London, United Kingdom Background: Waldenström’s Macroglobulinaemia (WM) is a rare B-NHL, with an incidence of 0.55 per 100,000 per year in the UK (1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10940855	These results suggest that EFNB2 expression is a poor prognostic marker in patients with multiple myeloma.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "results", "suggest", "that", "EFNB2", "expres...
PMC6461034	In the “kinome” analysis, CDK1, CDK2, and CDK3 share a second place, based on phosphopeptides that cannot be unequivocally assigned to either of them.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10170482	However, how ECM-derived mechanical cues regulate tumor cell metabolism and support dormancy of HCC cell is largely unknown.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "how", "ECM-derive...
PMC10674574	Permeability tests are generally performed in at least three repetitions .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Permeability", "tests", "are", "generally", "performed", "in", "at", "least", "three", "repetiti...
PMC9587298	On the other hand, co-incubation treatment did not show significant protection against MGO (Jiménez-Aspee et al., 2016).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "On", "the", "othe...
PMC9429973	The decline in BM blasts was slower in the placebo+AZA arm (53.7%, 34.6% and 19.6% at baseline, week 9 and week 17, respectively).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11803918	These results indicated the successful DAMP release and hybrid exosome-mediated ICD effect inside A375 cancer cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O" ], "tokens": [ "These", "results", "indicated", "the", "successful"...
PMC8875242	The inhibitory effects of atazanavir, darunavir, ritonavir, and saquinavir are consistent with results from previous studies using other in vitro experimental models and with reported increases in the AUC of digoxin and dabigatran etexilate in vivo .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11799978	Our data show that the 4T1 CM had a promigratory effect on CAFs (Figure 3F).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "data", "show", "that", "the", "4T1",...
PMC8164677	indicates P <0.001. ###	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "indicates", "P", "<", "0.001", ".", "#", "#", "#" ] } ]
PMC9429973	Methods: Patients referred to a hematological department in Denmark with suspicion of MN (excluding myeloproliferative disorders) were included in the study.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11367146	MMP2 (B) MMP9 in IL-1β induced SW-982 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "MMP2", "(", "B", ")", "MMP9", "in", "IL-1β", "induced", "SW-982", "cells", "." ...
PMC11680982	combined with endocrine therapy (fulvestrant, 100 mg/kg, i.m.),	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "combined", "with", "endocrine", "therapy", "(", "fulvestrant", ",", "100", ...
PMC11640555	To study the influence of GBM-secreted factors on human brain endothelial cells, brain microvascular endothelial cells (hCMEC/D3) were used.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O" ], "tokens": [ "To", ...
PMC11541241	The Rheb GTPase protein functions as a conserved TOR kinase regulator, is controlled by the TSC complex, and can activate TORC1 (Yang et al., 2021).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11644761	This is a technique that involves the methylation-sensitive restriction of genomic DNA, coupled with two consecutive PCR reactions to identify altered methylation patterns at different sites with a preference for those rich in GC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11424574	A, B) Stable MTA2 knockdown in HOS and 143B cells was ascertained by western blot and RT-qPCR assay. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "...
PMC11047729	It was found that the inhibition grows in a dose- and time-dependent manner.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "was", "found", "that", "the", "inhibition", "grows", "in", "a",...
PMC11794847	Furthermore, in our co-culture system, we established three groups: a control group (without jurkat cells), an activated jurkat group (with PMA + ionomycin), and a jurkat group (without PMA + ionomycin activation).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "B-CellLine", "O", "...
PMC9910796	After PCR amplification, melting curve analysis was performed for each reaction to verify PCR specificity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "PCR", "amplification", ",", "melting", "curve...
PMC8389560	Selenium (Se) is present as selenocysteine in 25 human proteins and enzymes and plays a protective role in several disease conditions, e.g., hypercholesterolemia, some cancers, and cardiovascular disorders .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11347429

DEGs and their known functions.

[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "DEGs", "and", "their", "known", "functions", "." ] } ]

PMC11429241

Also, there were some minor deviations from the 3D models overall in a range of up to 10 m. This can be explained by the substantially lower viscosity of PEGDA (0.101 ± 0.03 Pa·s for PEGDA vs. 1.5 ± 0.3 Pa·s for OrmoClear ), allowing a lot more motion of the material in the vat during printing.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC3675084

Immunofluorescence staining shows the appearance of giant, multinucleated cells (Figure 4) following BPR0L075 treatment of the resistant cells, suggesting that chromosome segregation do occur at least to some extent in paclitaxel-resistant cells but cytokinesis failed.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10329237

The cell lysates were combined with an equivalent volume of 2X Laemmli sample buffer.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cell", "lysates", "were", "combined", "with", "an", "equi...

PMC11546117

A sample was taken from each dosing solution.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "sample", "was", "taken", "from", "each", "dosing", "solution", "." ] } ]

PMC11683240

Figure 13α1AT levels correlate with B. pertussis infection and leukocytosis.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Figure", "13α1AT", "levels", "correlate", "with", "B.", "pertussis", "infection", "and", "leukoc...

PMC9429973

Image: Summary/Conclusion: With limitations characteristic to any retrospective analysis, this real-life study demonstrated similar ORR in patients treated in first relapse with DRD or KRD,shorter time to best response with KRD but longer PFS with DRD.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

He was started on romiplostim, that was escalated weekly (Figure solid curves).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "He", "was", "started", "on", "romiplostim", ",", "that", ...

PMC11264242

As a specificity control, we examined the same FYN gene locus by ChIP-qPCR using the non-immune IgG antibody, but no signal was apparently enriched in the IgG-purified DNA product (Figure 2B, white bars).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11790599

Images were visualized through DAPI and FITC filters of fluorescence inverted microscope (Leica DM2500 Fluorescence Microscope) at 20 × objective.

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PMC11519788

The sustained STAT3 activation has been linked to the acquisition of CSC properties and the promotion of carcinogen-induced UBC progression 9,40.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "sustained", ...

PMC9024365

Transfection was performed with 2 μg of DNA using Lipofectamine 2000 (Invitrogen).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Transfection", "was", "performed", "with", "2", "μg", "of", "DNA...

PMC10728200

All samples were normalized based on their protein content.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "samples", "were", "normalized", "based", "on", "their", "protein", "content", "." ] } ]

PMC11277157

It is known that siRNA delivery reagents may induce stress in the subjected cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "is", "known", "that", "siRNA", "delivery", "reagents", "ma...

PMC11568601

Utilizing an EZ-press RNA Purification Kit (EZBioscience, Roseville, USA), total RNA was extracted following the producer’s protocol.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Utilizi...

PMC11509224

The literature has reported 138 bioactivity data entries for these compounds, with 17, 4, and 1 compounds exhibiting two, three, and four different types of bioactivities, respectively.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10976516

OVs as a platform for transgene delivery.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "OVs", "as", "a", "platform", "for", "transgene", "delivery", "." ] } ]

PMC11271278

D HiChIP, H3K27ac ChIP-seq (derived from HiChIP reads), and copy number profiles at DNA segments of the MYC ecDNA in NCIH2170 cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", ...

PMC11190062

For analyses of TLR expression in primary myeloma cells from patients, RNA sequencing data from CD138 cells (MMRF_CoMMpass_IA14a_E74GTF_Salmon_Gene_Counts) were downloaded from the Multiple Myeloma Research Foundation CoMMpass IA14 release (https://research.themmrf.org/).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC5535901

TRIzol, AffinityScript Multiple Temperature cDNA Synthesis kit, and TaqMan real-time PCR primers and probes were obtained from Life Technologies/ThermoFisher Scientific (Waltham, MA, USA).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Results: As of 27 SEP 2021, 15 pts received PV and 10 pts received PVR.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", ":", "As", "of", "27", "SEP", ...

PMC11495567

These were then exposed to blocking buffer (1% BSA) solution for 30 mins on a shaker.

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PMC11225860

The ploidy classification performed by QuPath highlights normalploid cells in green and polyploid cells in blue (C).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "ploidy", "classification", ...

PMC8164677

Figure 6Illustrates E-values (Kcal/mol) of best docked poses of wedelolactone and standard drugs with hepatocyte growth factor receptor (cMET), checkpoint kinase 1 (Chk1), ecto-5′-nucleotidase (CD73), mammalian target of rapamycin (mTOR1), nuclear factor erythroid 2–related factor 2 (Nrf2), hypoxia-inducible factor 2-alpha (HIF2α), with heat shock protein 60 (HSP60), insulin-like growth factor (IGF1), P300/CBP-associated factor (PCAF), bromodomain protein 1 (Brd1) and acetyl transferase tip (AT tip60).Figure 7Shows 2D best pose of (A) hepatocyte growth factor receptor (cMET) with wedelolactone; (B) hepatocyte growth factor receptor (cMET) with crozotinib; (C) checkpoint kinase 1 (Chk1) with wedelolactone; (D) checkpoint kinase 1 (Chk1) with anacardic acid.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11574271

E Transfection of 5637-shRON cells with a HIF-2α plasmid and J82-oeRON cells with HIF-2α-targeting siRNA was performed, followed by western blot analysis to assess the expression levels of HIF-2α and MMP12.

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PMC8540611

When cells with complexes are incubated for a longer time, those that have undergone apoptosis will already have been destroyed, and the number of cells in which the necessary gene silencing process has not occurred will increase due to proliferation.

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PMC3675084

At present, few conventional anticancer treatments can overcome multidrug resistance by inducing cell death via mitotic catastrophe.

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PMC11723947

P values were calculated using multiple unpaired t test with Holm-Šidák correction.

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PMC11680578

The current treatment for ovarian cancer typically involves a combination of surgery and the use of drugs such as platinum-based cytotoxic agents, anti-angiogenic drugs, etc.

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PMC10976516

Other studies investigated the use of DCs as delivery vectors for OV.

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PMC8348645

The appearance of red colour in the lower layer of chloroform indicates the presence of steroids.

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PMC9429973

Treatment discontinuation occurred in 17pts (36%) – most commonly due to toxicity (n=8; 17%) and lack of efficacy (n=4; 8.5%).

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PMC10587429

Experimental timeline showing that the non-humanized mice were injected with luciferase expressing A673 cells orthotopically into the tibia and the tumor bearing mice were treated with control IgG or magrolimab (MAG) (100 ug/animal, i.p.)

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PMC11755519

In addition, the exosomes tested promoted the proliferation of normal fibroblasts in in vitro culture.

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PMC11655498

Additionally, as a transcription activator, SM binds to and recruits cellular XPB (xeroderma pigmentosum group B-complementing protein, a subunit of TFII H), subsequently targeting the promoters of late genes (Verma et al., 2020).

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PMC10582049

Interestingly, we did not observe a significant difference in proportion between FAPACTA2 and CTHRC1FAP CAFs in the indolent and aggressive groups.

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PMC11389534

Functional regulation of UFMylation in innate immunity.

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PMC11591794

In NucBlue staining, GA IC50 and DOX IC50 doses were determined to suppress cell proliferation and thus cause a decrease in cell number.

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PMC11714165

This co‐assembled fluorous‐tagged peptide nanoplatform provides a promising approach for developing the next generation of peptide‐based nanomedicines.

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PMC11468365

For the metric, MultiComb outperforms DeepDSC by + 0.04, MatchMaker by + 0.03%, and DeepDSC by + 0.02.

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PMC11697189

N-O) Transwell migration and invasion were evaluated in the A498 cells (P-Q) Transwell migration and invasion were evaluated in the ORCS2 cells.

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PMC9424261

Data were analyzed using Student’s t test and expressed as mean ± SD from three independent experiments. **

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PMC11750712

ICANS were graded according to grading criteria by ref. .

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PMC11786704

Six-week-old male rats (C57BL/6, weighted about 20 g) were intraperitoneally injected with 100 mg/kg streptozotocin (STZ, Sigma-Aldrich) for seven consecutive days.

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PMC10092581

Both Au(I) and Ag(I) complexes were markedly effective, without significant differences, in terms of antiproliferative activity and cellular redox state alterations, thus suggesting that the selenourea moiety plays a key role in cancer cell response to metal complexes.

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PMC11697065

Map9 has been associated with chromosomal instability , whereas Tmem39b has been described as a cell proliferation regulator.

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PMC11742047

The Lipid Annotator method was set as follows: ion species [M + H], [M + Na], and [M + NH4] for positive ESI mode; [M-H], [M + COOH], and [M + CH3COOH-H] for negative ESI mode.

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PMC11634794

The stable transfection strains were selected using purinomycin at a concentration of 2μg/ml (Sigma-Aldrich, St. Louis, MO, USA), which based on our previous experiments which found that 2μg/ml of puromycin can effectively kill non-transfected cells while allowing transfected cells to survive and proliferate.

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PMC10507284

Ranked dots and scatter plots showing the TROAP‐derived risk score distribution and patient survival statuses (n = 263). (

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PMC11420784

The arrow indicates NDP52+ bacteria, and the square frame indicates NDP52 granules.

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PMC9429973

Typically diagnosed in childhood, β-thalassemia is marked by the inability to produce hemoglobin, which results in chronic anemia.

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PMC10048572

Oshima et al. studied paired tumor samples at the onset and recurrence of childhood ALL using whole exome and whole genome sequencing.

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PMC10578720

NF-κB P65 reportedly inhibits PGC-1α function and PGC-1α target gene transcription through protein-protein interactions, while SIRT3 functions as one of the downstream target genes of PGC-1α.

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PMC11247842

SCS from Holstein and Jersey phenotypes were DRP derived from a test-day evaluation model.

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PMC7039683

We engineered a 606 bp element within IRF6-9.7 into the GFP reporter vector and injected it into wild-type embryos.

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PMC6133382

Thus, differences in glycosylation between the vaccine immunogens from the RV144 trial and virus particles could, in part, explain the low efficacy of RV144 and other gp120-based vaccines and their inability to elicit bN-mAbs.

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PMC11765988

M2 (“healer”) macrophages (CD163+) produce anti-inflammatory cytokines, such as IL-4, IL-10, and TGF-β, to modulate the inflammation and protect the organism .

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PMC11806106

Cells were tested on a regular basis for mycoplasma.

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PMC11772585

We initially found that the protein levels of METTL1 in the tumor tissues originating from METTL1-knockdown cells were significantly decreased than those originating from control cells (Supplementary Fig. S3A, B).

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PMC7642379

Non-significant genes have gray bars.

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PMC11483468

With the forced exogenous expression of the LPTS/PinX1 gene in cancer cells, such as hepatocellular carcinoma (HCC) and urothelial carcinoma of the bladder cells, cellular telomerase activity and cells proliferation were inhibited in vitro and in vivo (10,21).

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PMC6889484

Replication kinetics from duplicate flasks are indicated. (

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PMC11040965

Data from real-time PCR and the 2 method, normalized to RNU44 (miR29b) and GAPDH (DNMT3B) and expressed as fold change relative to the average value for plasma cells from 10 controls (patients with benign hematological diseases).

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PMC9429973

Overall response rate (ORR) was estimated by both response definitions.

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PMC11252553

The percentages of apoptosis were higher at 48 hours compared to 72 hours post-irradiation (71.96, 66.77, and 62.73% for 48 hours, and 50.69, 42.92, and 45.85% for 72 hours post-irradiation at 4, 8, & 12 Gy, respectively).

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PMC7057940

Finally, the slides were evaluated using the G-banding protocol (20).

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PMC11683240

FCS, fetal calf serum; Gαi, α-subunit of inhibitory G protein.

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PMC11711935

In melanocytes, sFRP2 acts as a melanogenic stimulator through β‐catenin signaling leading to the up‐regulation of MITF and TYR .

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PMC9429973

Death was principally attributable to COVID-19 in 58 patients (69.0%) and contributable by COVID-19 in 15 (17.9%).

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PMC9429973

The median number of cycles to response was 1[1-4].

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PMC10158546

We found ReN cells within these thin 3D cultures to self-arrange into spheroid-like clusters of cells (Figure 1c), similar to 3D neurospheroids produced by culturing ReN cells in low-attachment round-bottomed plates or microwell chips .

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PMC9429973

Bone marrow samples were collected at screening and C2D15 for immunohistochemistry.

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PMC10142392

The AB2-type miktoarm copolymer (PEG-PCL2) was synthesized using a "core-first" strategy, which involves functionalizing the end of the mPEG chain, leading to the formation of two initiation centers on the mPEG macroinitiator for PCL arm growth.

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PMC9429973

Treatment groups were comparable by sex and race.

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PMC6182045

The efficiency of the recovery process for the purification of TZ97008-rgp120 produced in CHO-S cells and MGAT1- CHO cells were compared.

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PMC10877303

Preliminary, the first drug candidate, Kihadanin B expressed six interactions with 3CL where one Pi-Alkyl bond at HIE194, two Conventional Hydrogen bonds at GLU169, and GLY146, and three Carbon Hydrogen bonds at MET168, HIS166, and CYS145 was observed.

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PMC9429973

С. 63-68].

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PMC8633974

Although concurrent viral elimination strategies that include broadly neutralizing antibodies (bnAbs) , immune modulation , and chimeric antigen receptor (CAR)-T cells show promise in mice, selection for bnAb resistant strains , viral rebound , and adverse side effects have been reported in monkeys and humans.

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PMC9429973

E. Uppal, A. Otamas, J. Khwaja, H. McCarthy, J. Kothari, A. Rismani, D. El-Sharkawi, C. Kyriakou, S. D’Sa Department of Haematology, University College London Hospitals NHS Foundation Trust, London; Department of Haematology, Royal Bournemouth Hospital, Bournemouth; Department of Haematology, Oxford University Hospitals NHS Foundation Trust, Oxford; Department of Haematology, The Royal Marsden Hospital NHS Foundation Trust, London, United Kingdom Background: Waldenström’s Macroglobulinaemia (WM) is a rare B-NHL, with an incidence of 0.55 per 100,000 per year in the UK (1).

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PMC10940855

These results suggest that EFNB2 expression is a poor prognostic marker in patients with multiple myeloma.

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PMC6461034

In the “kinome” analysis, CDK1, CDK2, and CDK3 share a second place, based on phosphopeptides that cannot be unequivocally assigned to either of them.

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PMC10170482

However, how ECM-derived mechanical cues regulate tumor cell metabolism and support dormancy of HCC cell is largely unknown.

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PMC10674574

Permeability tests are generally performed in at least three repetitions .

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PMC9587298

On the other hand, co-incubation treatment did not show significant protection against MGO (Jiménez-Aspee et al., 2016).

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PMC9429973

The decline in BM blasts was slower in the placebo+AZA arm (53.7%, 34.6% and 19.6% at baseline, week 9 and week 17, respectively).

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PMC11803918

These results indicated the successful DAMP release and hybrid exosome-mediated ICD effect inside A375 cancer cells.

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PMC8875242

The inhibitory effects of atazanavir, darunavir, ritonavir, and saquinavir are consistent with results from previous studies using other in vitro experimental models and with reported increases in the AUC of digoxin and dabigatran etexilate in vivo .

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PMC11799978

Our data show that the 4T1 CM had a promigratory effect on CAFs (Figure 3F).

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PMC8164677

indicates P <0.001. ###

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PMC9429973

Methods: Patients referred to a hematological department in Denmark with suspicion of MN (excluding myeloproliferative disorders) were included in the study.

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PMC11367146

MMP2 (B) MMP9 in IL-1β induced SW-982 cells.

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PMC11680982

combined with endocrine therapy (fulvestrant, 100 mg/kg, i.m.),

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PMC11640555

To study the influence of GBM-secreted factors on human brain endothelial cells, brain microvascular endothelial cells (hCMEC/D3) were used.

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PMC11541241

The Rheb GTPase protein functions as a conserved TOR kinase regulator, is controlled by the TSC complex, and can activate TORC1 (Yang et al., 2021).

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PMC11644761

This is a technique that involves the methylation-sensitive restriction of genomic DNA, coupled with two consecutive PCR reactions to identify altered methylation patterns at different sites with a preference for those rich in GC.

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PMC11424574

A, B) Stable MTA2 knockdown in HOS and 143B cells was ascertained by western blot and RT-qPCR assay. (

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PMC11047729

It was found that the inhibition grows in a dose- and time-dependent manner.

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PMC11794847

Furthermore, in our co-culture system, we established three groups: a control group (without jurkat cells), an activated jurkat group (with PMA + ionomycin), and a jurkat group (without PMA + ionomycin activation).

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PMC9910796

After PCR amplification, melting curve analysis was performed for each reaction to verify PCR specificity.

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PMC8389560

Selenium (Se) is present as selenocysteine in 25 human proteins and enzymes and plays a protective role in several disease conditions, e.g., hypercholesterolemia, some cancers, and cardiovascular disorders .

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