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BioData-CellLine_annotated

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PMC4360730
As metadata from other experiments are annotated to terms in an ontology, those experiments become more accessible.
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PMC11604830
Three different nanosystems, namely lipid‐based micelles, liposomes, and perfluorocarbon‐based nanoemulsions, were synthesized, characterized by high resolution NMR and then visualized by H CSI at 300 MHz.
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PMC11281366
Accordingly, we document that enhancing miRNA-26a in HIV-1-infected cells reduces CD59 expression and packaging into virions, a condition that impacts their susceptibility to antibody-dependent complement-mediated lysis (ADCML).
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PMC11026382
Color coding follows from (a) with the addition that positions with strong positive epistasis are magenta.
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PMC11723947
k UMAP plot of tumor-infiltrating CD4 T lymphocytes from melanoma patients.
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PMC7348793
Human mtDNA manifests a minimal length heterogeneity of the control region, which has biased our views.
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PMC11697065
High and low IgG-expressing CHO clonal populations were identified from the preliminary titre screen (data not shown).
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PMC4270159
Please see Power Calculations for details.
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PMC11489351
We transfected a large pool of MCF10A cells with the reporter plasmid and then plated cells in triplicate on imaging dishes for 24 h to recover.
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PMC11782508
For the isolation of P. aeruginosa, Cetrimide agar plates (HiMedia, India) were used.
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PMC10578720
Our findings suggest that SIRT3, which agonizes macrophages and hepatocytes, has a synergistic effect on eliminating HBV.
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PMC11473843
After this step, the sections were pretreated for 30 min with 3% hydrogen peroxide (Sigma-Aldrich, 216763) in PBS, washed twice with 0.1 M Tris-Buffered Saline (TBS), blocked for 1 h in 2% bovine serum albumin (BSA) in TBS containing 0.1% Polysorbate 20 (TBS-T), followed by 10 min in 2.5% normal horse serum (Vector, S-2012) and finally incubated with primary antibodies in blocking solution.
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PMC11502443
Differences between the pharmacology of the GIP receptor variants may help to explain differences in the metabolic phenotypes observed and the effect of different GIP receptor agonists on metabolism.
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PMC11095939
Representative immunofluorescence (IF) staining of Mecp2 (red) and Alb (green), together with DAPI (blue) for nuclei in liver sections at different time points after PHx.
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PMC11792888
The culture medium was used as the negative control.
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PMC9429973
The first two authors contributed equally to this work.
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PMC9429973
Forty-six chromothriptic events were identified.
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PMC10850553
To induce rupture-prone IAs, 10 week-old female rats were subjected to the bilateral ovariectomy, the ligation of the left carotid artery, the right external carotid artery and the right pterygopalatine artery, and systemic hypertension achieved by the combination of a high salt diet and the ligation of the left renal artery under the general anesthesia as same.
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PMC6835428
As HGSOC is mostly confined to the peritoneal cavity, the IP route enables a higher local concentration .
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PMC9429973
At BL, 1 pt had thiamine below the 70 nmol/L lower limit of normal (LLN), which normalized before the pt received FEDR.
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PMC11361748
The source data used to derive the numerical values reported here can be found in S1 Data.
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PMC9583612
The significance of accounting for spatial and temporal variations in emissions through multiscale, contemporaneous measurements has been documented in the literature.
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PMC11680982
inhibited tumor growth in HR/HER2-low breast cancer xenografted mice, but the effect was not as significant as in the HR/HER2-0 subtype.
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PMC11536589
Distinct gene signatures of each cluster.
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PMC11519583
Transfected cells were selected using puromycin and assessed for mWnt11 expression to obtain cells expressing mWnt11 (Cos7-Wnt11).
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PMC11489351
We first identified culture conditions to raise and lower pHi in adherent MCF10A cells over 24 h. For all experiments, we measure pHi at the population level using the cell-permeable pH-sensitive dye 2′,7′-bis-(2-carboxyethyl)-5-(and-6)-carboxyfluorescein, acetoxymethyl ester in a plate reader assay as previously described (30, 31).
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PMC8164677
Obesity is also a risk factor while results on consumption of meat and alcohol appear to be contradictory.
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PMC11591794
In this study, GA, which has been revealed to have anticancer properties in many types of cancer, was preferred as an alternative product that would reduce the side effects of an effective and highly cytotoxic agent such as DOX in the treatment of cervical cancer.
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PMC11448304
In addition, subcellular localization of the DEPs was performed (Fig. 3g), and most upregulations in RA549 occurred in cytoplasm and on plasma membrane, while downregulations occurred in the nucleus.
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PMC11578343
The data was transferred by USB to a PC running a custom MATLAB data acquisition interface, available on GitHub (https://github.com/sohnlab/mz‐visco‐NPS).
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PMC11188874
E.G7-Ova or EL.4 cells were incubated with drugs as indicated for up to 72 hours.
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PMC10317042
The calculated combination index values are shown in the histogram.
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PMC9621239
Indeed, this study also showed that wild-type HBx could inhibit HCC cell proliferation compared with the control group in vivo and in vitro.
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PMC11194678
In sharp contrast, expression of the LLPS-deficient STAU1 5KE mutant or the RNA-binding-deficient STAU1 HKΔRBD4 mutant exhibited no observable impact on mTOR and autophagic pathways (Fig. 4 D and Fig. S3, B and C).
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PMC11435360
The gold-standard treatment for MIBC involves neoadjuvant chemotherapy followed by radical cystectomy.
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PMC8996378
Some compounds from other species, such as Pseudolarix, Taxus, Briareum, Sindora species and so on, also have shown certain reversal activity.
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PMC11623887
In this pathway activation of signal transducer and activator of transcription 5 (STAT5) plays a direct role in B19V DNA replication.
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PMC11047729
Cis-fatty acids surpass trans-fatty acids in effectivity and their inhibitory abilities increase with the number of double bonds, which makes docosahexaenoic acid (DHA) the most effective of them all .
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PMC11575040
A Real-time PCR analysis of LINC00094 expression in five melanoma cell lines.
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PMC10093184
400 µm) and cell density, the central zone did not show signs of necrosis.
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PMC11676169
Interestingly, the acetylation status of α-tubulin was not significantly altered under these experimental conditions (differently from what was observed using the Class I/II HDAC inhibitor trichostatin A/TSA; Figure 4E).
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PMC9429973
There were no substantial differences between the machine learning methods in the validation set; we chose the nearest neighbor technique as the simplest alternative.
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PMC8073654
In a study on the evaluation of solvent fractions of Z. cassumunar on in vitro antioxidant and α-glucosidase inhibitory assay , the chloroform fraction showed 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity with an IC50 value of 78.19 μg/mL, while the hexane fraction demonstrated H2O2 scavenging activity with an IC50 value of 34.40 μg/mL and α-glucosidase inhibitory activities with an IC50 value of 61.02 μg/mL. The ethanol extract of the Z. cassumunar rhizome with 7% curcumin content was evaluated for its effect on superoxide dismutase (SOD) enzyme activity in rats fed a high-fat diet (HFD), which resulted in increased SOD activity upon oral administration of the extract (400 mg/kg, o.p.)
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PMC10362265
First row in both (a) and (b) illustrates the crystal complex, and the second and third rows show the computational models.
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PMC10656496
Thus, we lack adequate clinical endpoints and methods to identify all efficacious second strikes.
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PMC8009078
In the above study, the average RoG of ligand1 and ligand2 was found to be 20.63 and 20.32 Å, respectively.
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PMC8992508
Chemical stability both in phosphate buffer solution and in human plasma was evaluated, indicating that most of the obtained molecules were stable in both matrices.
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PMC11623887
Pimozide, an FDA-approved drug that dephosphorylates STAT5, inhibits B19V replication in EPCs and can be used for the virus-related diseases.
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PMC11779960
Diamond indicates % of patients with TCRβ negative cells above the threshold.
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PMC11640419
5Z,9Z-dienoic acids demonstrate considerable potential for biological activity against the primary enzymes that relieve torsional stress from the DNA molecule during its biosynthesis.
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PMC11012012
In many types of B-CLPD, their expression patterns have not been analyzed yet.
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PMC9024365
We noted a distribution of GluA1 or GluA2 cluster sizes in SD4 co-expressing cells.
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PMC11787651
Treatment with each of these drugs is expected to produce large global changes in histone modifications.
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PMC10810426
It is well-established that the HIV PIC relies on the nuclear pore for entry into the nucleus of quiescent cells.
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PMC9878562
BLT1R (mAb 203/14F11) surface expression on VAL-wt (upper panels) and VAL-ko (lower panel) cultured in vitro (left panels) or ex vivo (right panels).
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PMC10529414
Methods: We performed ChIP-seq analysis of tumor samples from a patient diagnosed with lung adenocarcinoma to evaluate the target genes of the RUNX2 TF.
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PMC5925824
Human IgG1 LY3300054 In MLR assays, LY3300054 also displayed biological activity in combination with the anti-CTLA4 antibody ipilimumab.
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PMC10530622
Bifidobacterium spp.
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PMC11706297
In addition, thiazole, a versatile scaffold in medicinal chemistry, has an electron-donating sulfur atom and an electron-withdrawing nitrogen atom (–C=N).
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PMC11637716
, a head circumference of 30.5 cm (6.
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PMC10988555
To the best of our knowledge, these are the first examples of half-sandwich complexes of Co(III) bearing an unsubstituted cyclopentadienyl and containing a monodentate phosphane and bidentate N,N-heteroaromatic ligands ever reported in the literature.
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PMC11774747
Indeed, CD19.CAR-CMVST, when stimulated through their native TCR with pp65pepmix-loaded autologous PBMCs, exhibited higher expression of genes linked to persistence and memory, such as KLF2, TCF7, and Lef1, compared to CAR stimulation alone (93).
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PMC11087055
Scale bars: 500μm.
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PMC8662250
Our data indicate, in conclusion, that CBD is a powerful inhibitor of SP protein enterotoxicity in vitro.
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PMC9220170
Next, lentiviral particles containing the SELENOM-KD and SELENOT-KD were prepared.
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PMC5415764
The PTX and TET co-loaded LPNs with a core-shell lipid-polymeric structure and iRGD peptides on the surface were formulated by nanoprecipitation and self-assembly (Fig. 1C).
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PMC3734024
Grey histograms represent isotype control antibody staining. (
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PMC11591030
Specifically, the LPS + PDTC + AOP group showed no significant changes in all the indicators.
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PMC11536589
Yellow and purple represent high and low expression, respectively. (
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PMC9429973
First, we designed, cloned, and purified RAP-GRL from a mammalian cell line.
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PMC11477621
The mixture was stirred for 30 min at 0 °C.
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PMC11597291
= 495 nm, λem.
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PMC11055323
One of the consequences of HDAC exclusion may be the accumulation of acetylated histones.
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PMC5308810
During our studies, we observed significant differences in the morphology between the isolated CXCR4 and CXCR4 clones (Fig 2E), suggesting that chemotherapy might also induce the EMT of a small population of OVC cells.
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PMC11719944
The significance level of the correlation was assessed using the Bonferroni-adjusted statistical test.
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PMC10588957
Based on the results, DATS treatment significantly increased the protein expression level of the LC3II-LC3I ratio (Fig. 3).
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PMC9516447
To test this, we utilized the PERK inhibitor GSK2606414 to block eIF2α phosphorylation.
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PMC11790971
After imaging each replicate, FAD (5 mM) and NADH (10 mM) solution samples were prepared and imaged, which were later used in intensity normalization and illumination correction of 2PF and 3PF channels, mitigating potential variability caused by fluorescence signal fluctuations and inhomogeneous background illumination.
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PMC7823217
Tumor constructs can also be printed on microfluidic chips or integrated with similar platforms to automate the screening assay and perform the analysis of a number of drugs simultaneously as well as determine the response and mechanism in real-time .
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PMC7348793
To that end, we emulated the total cellular DNA from the COS-7 cell line by mixing the genomic DNA from a human osteosarcoma cell line 143B ρ that lacked mtDNA with plasmid DNA that contained cloned C. aethiops control regions with three, four or five 108 bp repeats in a molar ratio 1:20 (mtDNA in COS-7 cells is present at approximately 20 copies per cell, results not shown).
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PMC9429973
MVA showed Black race (HR 1.5, 95% CI 1.4 – 1.6) as the strongest independent prognostic variable for worse OS controlling for year of diagnosis, suggesting race was a significant factor in OS in the era of modern therapies.
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PMC9341513
DNA was fluorescently labeled by nick translation.
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PMC9429973
Briefly, patients with untreated DLBCL were randomized 1:1 using the same stratification factors to receive six cycles of Pola-R-CHP or R-CHOP, plus two cycles of rituximab alone.
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PMC11449273
Immunoblots representative of the nuclear distribution of β-catenin (a) and NPM (b) in various transfectants.
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PMC9429973
200μl /20g), and subjected to daily restraint; (3) CLOD group, treated with clodronate liposomes only; (4) CTRL + R received control liposomes (i.p.
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PMC11365427
Flow cytometry analyzes the effects on the cell cycle of MM cell lines after 48 h of phenylalanine deprivation. (
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PMC11790971
b Schematic of the multimodal nonlinear optical microscopy system.
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PMC11740207
The precursor stages of MSCs have garnered significant interest, particularly in exploring the mechanisms of carcinogenesis (Bhartiya et al., 2023b).
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PMC11509224
The compound hamigeran R (117) was the first benzonitrile-based marine natural product, while the compound hamigeran S (118) was the first dimeric structure in the series.
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PMC9429973
The most common (>10%) grade 3/4 TEAEs were febrile neutropenia (36%) and thrombocytopenia (18%).
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PMC11731614
Several microRNAs have been associated with pain in diabetic neuropathy (Fan et al., 2020), but the KDEV microRNA content has not yet been identified in the context of PDN.
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PMC8345486
The m/z was measured in a positive and negative modes.
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PMC9429973
Summary/Conclusion: Rather than gedatolisib, omipalisib could significantly inhibit mitochondrial biogenesis and suppress the respiration of mitochondria in myeloid leukemia cells.
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PMC10810426
Recently, there has been debate as to where in the cell HIV reverse transcription occurs.
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PMC6102174
Two xanthones, 1,8-dihydroxy-3,5-dimethoxyxanthone and norswertianolin displayed remarkable inhibition on HBV DNA replication with IC50 values of 0.07 (SI > 71.4) and 0.01 (SI > 269.0) mM, respectively.
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PMC11763111
E Flow plots showing the efficiency of CD38 CAR and LLT1 overexpression in CAR-T cells Additionally, the TRAC, B2M, CIITA, and CD38 genes in primary human T cells were disrupted using the CRISPR/Cas9 technology to prevent GVHD .
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PMC9429973
The independent hazard elements for sPGF were a history of refractory CMViremia and grade 3-4 aGvHD.
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PMC6034753
Bound protein were resolved on an SDS Bis-Tris gel along with 10% of input protein and western blotted with HA-HRP direct conjugate antibodies.
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PMC11537649
Take logarithmic growth stage cells and evenly lay them on a 6-well plate.
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PMC11754094
The whiskers extend down to the minimum and up to the maximum value.
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