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OTAR3088
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BioData-CellLine_annotated

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PMC11680049
By localizing as a dense continuous layer around the perimeter of the leaf and stem, polyphenols contribute to the resilience of Sequoia against viral and fungal diseases as well as damage from animals, thus playing a role in the mechanisms that ensure the remarkable longevity of these giant relict plants, as has been reported in the literature .
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PMC8658661
At the same time, the use of HepG2 cells to study the metabolism of anticancer drugs is acceptable because there is a similarity in the expression of phase I, II, and III drug metabolism/transport proteins in cells with HCC and HB.
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PMC11766174
On average, 194,581 ± 40,005 cells per dilution were scanned for CA-ICC analysis.
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PMC11615828
The addition of rapamycin (Rapa) immobilizes FKBP‐IFT88 onto FRB‐MAP4m‐labeled axonemes in cilia.
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PMC7081114
P < 0.05 was considered significant, P < 0.01.
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PMC8992508
Flavonoids and chromone derivatives The chromone derivative 3 (MBL-II-141) [Figure 3] is a potent and selective BCRP inhibitor endowed with excellent in vivo activity and very low toxicity.
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PMC11388384
Importantly, we found that SCUBE1 did not alter the receiver cell response threshold to SHH, suggesting that SCUBE1 modulation of SHH gradients was not mediated by heightened sensitivity or by changes to the stability of SHH in the cell culture (SI Appendix, Fig. S6A).
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PMC9080589
For migration assay, the transfected TPC-1 and BCPAP cells (5 × 10 cells per well) suspended in 100 μl serum-free medium were seeded in the upper compartment, while the lower chamber was filled with 500 μl of DMEM containing 10% FBS.
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PMC11525028
Zong et al. reported that NAT10 facilitates the ac4C modification of AXL mRNA, enhancing AXL mRNA stability and promoting the proliferation and metastasis of tumor cells.
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PMC11765988
Decreased sun exposure causing 1,25-hydroxyvitamin D deficiency (the biologically active form of vitamin D) has been interlinked to reduced production of cathelicidin, an antimicrobial peptide.
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PMC11768927
Similarly, Muscolini et al. identified SIRT1, a member of the sirtuin family that functions upstream of p53 to inhibit its apoptotic activity as a viral restriction factor that promotes resistance to VSV oncolysis.
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PMC11779876
Furthermore, our results are consistent with a recent flow cytometry investigation on T cell lymphomas with specific TRBC1 and TRBC2 directed antibodies.
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PMC11422497
Aberrant circRNA expression correlates with clinicopathological features, tumor stage, metastasis, and patient prognosis in GISTs, suggesting their utility as potential biomarkers for diagnosis, prognosis, and therapeutic response prediction.
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PMC9436459
Activity (inhibitory ratio)Positive control (vitamine E, inhibitory ratio)Mulberrofuran J (1)91.2% 66.7%Mongolicin F (2)86.0%, p < 0.05 Mulberrofuran Q (30)85.6% 66.7%Mulberrofuran F (32)100% 67%Mulberrofuran K (40)*92.1% 35.9%Yunanensin D (43)67.9% 70.1%Albanol B (46)*100.0% 35.9%Albafuran C (50)76.2% 33.5%Guangsangon J (51)91.1% 33.4%Guangsangon A (52)84.9% 33.5%Yunanensin B (54)57.1% 70.1%Guangsangon E (56)88.1% 33.5%Kuwanon X (58)80.8% 33.5%Kuwanon Y (61)70.9% 33.5%Sorocein A (68)100% 67%Cathayanon C (70)95% 62.6%Cathayanon D (71)103% 62.6%Guangsangon B (75)83.7% 33.5%Guangsangon C (91)81.7% 33.5%Guangsangon I (106)93.9% 33.4%Wittiorumin A (107)73.0% 62.5%Wittiorumin B (108)82.0% 62.5%Guangsangon O (111)94.8% 31.9%Wittiorumin C (112)82.0% 62.5%Guangsangon M (114)98.3% 18.2%Guangsangon N (115)100.0% 18.2%Kuwanon O (119)63.0%, p < 0.05 Guangsangon D (120)77.6% 33.5%Guangsangon H (121)93.1% 33.4%Guangsangon K (122)91.8% 18.2%Guangsangon L (145)97.6% 18.2%Mongolicin B (161)83.6%, p < 0.05 *The working concentration of these samples including positive control vitamine E was 10 mg/L Antioxidant activities of MDAAs at concentrations of 10 μM *The working concentration of these samples including positive control vitamine E was 10 mg/L Ten MDAAs, mulberrofuran J (1), mulberrofuran C (6), inethermulberrofuran C (20), mulberrofuran G (31), mulberrofuran K (40), albafuran C (50), isomulberrofuran G (57), kuwanol A (64), kuwanon G (92), and kuwanon H (93), were systematically screened for their anti-Alzheimer's disease (anti-AD) properties on different targets such as tau aggregation, Aβ self-aggregation, and ChEs.
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PMC11764090
Traditional plant cold tolerance identification is still mainly performed by traditional evaluation methods using cold damage classification, and individual physiological and biochemical indicators for cold tolerance identification, which is simple and easy to implement and is usually used for plant resources, cold resistance analysis and identification.
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PMC11742231
Linking Technical Innovation to Clinical Impact: Ablation studies confirm the efficacy of the attention and fusion modules, contributing to more accurate predictions.
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PMC11791264
∗∗∗∗p < 0.0001 (One-way ANOVA followed by Tukey’s multiple comparison).
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PMC9119314
Thermodenaturation studies showed that in contrast to 1, analogue 2 did not intercalate into DNA (ΔTm values of 4 and 9°C for 2 and 1, respectively), with values below 5°C, indicating non-specific binding to DNA, suggesting that DNA intercalation is not involved in the antiplasmodial action of 2.
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PMC11787651
The HeLa cell line was obtained from the American Type Culture Collection.
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PMC11720808
A diagram of the xenograft design is illustrated in Figure 6A.
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PMC11291697
A reduction in GTDC1 levels, as we observed in our proband, was found in another individual with signs of neurodevelopmental disorder .
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PMC11627398
Excessive NK cell activation could enhance inflammatory response during sepsis, eventually leading to organ injury .
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PMC11806613
The indicated TNBC cell lines (4T1, MDA-MB-231, and BT549) and the triple-positive BC cell line BT474 were treated with OST-01 in a dose-dependent manner for 24 h. Left: Lipid peroxide levels were measured using a lipid peroxidation assay.
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PMC10671321
Cells were infected with a first dose of virus at 20,000 CG/cell, incubated at 37 °C for 5 h. Then A second dose of virus at 20,000 CG/cell was added and incubated for 2 h. MLCLs were rinsed and further cultured in DM medium.
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PMC10698968
Immediately after, 150 µl of the mixture was dispensed in every single well.
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PMC11411004
The volumetric yield enhancement observed can be ascribed to the approximately 2.43-fold increase in qmAb.
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PMC9874064
The anti-tumor effect of NP-Pt-USP1i via semi-quantitative analysis of bioluminescence intensity, ∗∗∗p ​< ​0.001 (ordinary two-way ANOVA).
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PMC9429973
F. Kapsouli, E. Sanidas, M. Mantzourani First Department of Internal Medicine, Laiko Hospital, Athens, National and Kapodistrian University of Athens; Department of Cardiology, Laiko Hospital, Athens, Greece Background: Immune thrombocytopenia (ITP) is an acquired thrombocytopenia caused by autoantibodies against platelet antigens.
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PMC11583010
As a means to reduce on-target skin toxicity observed with enfortumab vedotin (EV), an anti–nectin-4–monomethyl auristatin E (MMAE) antibody–drug conjugate (ADC) approved for patients with advanced urothelial cancer, 15A7.5, an anti–nectin-4 mAb that exhibited differential nectin-4–binding between tumors and primary keratinocytes, was selected for the development of ETx-22.
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PMC9611901
The effects measured in the exposed cells indicate that the leaching of potentially genotoxic chemicals from the same surface is variable and was highest after vegetable tanning, followed by synthetic tanning and chrome tanning.
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PMC5261804
Here, we have developed cell-line specific network topologies by removing PPIs in which one partner gene is deleted, mutated, or not expressed.
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PMC7215832
RX-3117 treatment leads to DNA hypomethylation and overexpression of proteins, such MGMT, E-cadherin, and p16, normally down-regulated by promoter hypermethylation.
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PMC11766332
Several findings suggest that B4GALT1 may be a susceptibility candidate gene related to glycobiology in ASD patients.
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PMC11216402
For COL1A1, we found the upstream distal peaks COL1A1_E1 and COL1A1_E2 differentially active in Mes-like and Epi-like GC cell lines and in primary TCGA-STAD tumors compared with normal stomach (Fig. 6D).
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PMC9429973
At the end of the follow-up Tfr2/Hbb animals had lower hepatic iron content than Hbb controls, showing that BM Tfr2 deletion may prevent secondary iron-loading in these mice.
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PMC9622879
Trade-off between benefits of homes in community with our proposed CEMS under different values of .
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PMC11732635
All procedures performed in this study were in accordance with the ethical standards of the institutional and/or national research committee(s) and with the Helsinki Declaration (as revised in 2013).
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PMC11574271
B The migratory capacity was assessed through a wound-healing assay.
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PMC9352806
Survivals were recorded every other day until all of the worms died.
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PMC10204952
Data of the MTT assay were calculated from three independent experiments (n = 3) with each experiment containing six replicates.
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PMC9429973
Patients after infection before the start of special treatment required a recovery period, which averaged 21.7 days, ranging from 7 to 60 days.
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PMC11743316
Hypoxia, which is a major characteristic of solid tumor cells in vivo, is caused by an imbalance between the tumor cells' rapid rate of reproduction and the blood's capacity to give oxygen and other nutrients.
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PMC11286266
Downstream analyses to obtain sgRNA read counts, gene rankings, and statistics were performed with MAGeCK software (Li et al., 2014).
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PMC11747467
P-value < 0.05; **, P-value < 0.01; ***, P-value < 0.001; ****, P-value < 0.0001; ns, not significant.
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PMC9429973
Here, we present initial results from the first 2 patients treated with RM-001.
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PMC11792766
Acetic acid interfered with the function of the LDH assay showing negative cytotoxicity values.
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PMC11701801
Finally, the expression of the KREMEN2 gene in deficient/fusion and nondeficient cell lines was compared.
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PMC9844987
As expected, the effect size for the most significant prQTL variant (lead SNP) for each promoter was positively associated with the expression variability of the promoter (Spearman’s rank correlation ρ = 0.16, p< 2.2 × 10, Figure 5—figure supplement 1A).
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PMC11190538
The amide I band arises principally from the C <svg xmlns="http://www.w3.org/2000/svg" version="1.0" width="20.666667pt" height="16.000000pt" viewBox="0 0 20.666667 16.000000" preserveAspectRatio="xMidYMid meet"><metadata> Created by potrace 1.16, written by Peter Selinger 2001-2019 </metadata><g transform="translate(1.000000,15.000000) scale(0.019444,-0.019444)" fill="currentColor" stroke="none"><path d="M0 440 l0 -40 480 0 480 0 0 40 0 40 -480 0 -480 0 0 -40z M0 280 l0 -40 480 0 480 0 0 40 0 40 -480 0 -480 0 0 -40z"/></g></svg> O stretching vibration of the peptide group.
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PMC9429973
Aims: We studied AIHA impact on pregnancy focusing on disease severity, treatment need and maternal/foetal outcome.
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PMC5916734
ELISA-determined specific productivity is shown as bars (left axis).
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PMC11317131
The gIII promoter strength was decreased by switching to host cells containing sequentially weaker promoters: ProB, ProA, Pro3 and Pro1.
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PMC11656048
The protein concentrations were determined using BCA protein assays.
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PMC11543885
Note: In the case of Flp-In T-REx HEK293, the concentration of hygromycin B is 300 μg/mL. For other cell lines, the minimum concentration is to be determined by testing a range of concentrations.
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PMC11013014
Following general procedure, the crude residue was purified by silica gel column chromatography, using DCM/EtOAc, 3:2 (v/v) as eluent, to obtain the expected product 17b as a white solid with a yield of 68%.
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PMC11286266
Frequency distribution of sgRNA in each sample, showing the median-normalised read counts.
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PMC9429973
Aims: To evaluate the role of CTPS1 as a novel target in myeloma, elucidate the molecular consequences of CTPS1 inhibition and test rationally designed combination therapy.
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PMC10938336
By graphing percent survival vs concentrations, IC50 values for various compounds were determined.
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PMC11539788
Briefly, cells from different groups were treated with CHX (20 µg/ml) for the indicated durations (0, 2, 4, and 8 h).
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PMC11655498
BPLF1 also deubiquitinates TOP2, inhibiting the DNA damage response induced by TOP2 and promoting viral production (Li et al., 2021).
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PMC10719213
Cladribine treatment at concentrations up to 10 nM in CCRF-CEM and 100 nM in Jurkat cells did not induce significant increase in mitochondrial DNA mutations.
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PMC11470381
Note: Perform the above analysis steps for both fluorescent channels to obtain polarization angles of both Piezo1 mCherry and actin-GFP across all time frames.
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PMC11699178
A, B qPCR and WB analysis of HIF-1α, VEGF-B, FGF2, and FGFR1 expression levels in ISsh-80, SK-OV-3, and SK-OV-3/GEM cells; C, D qPCR and WB analysis of HIF-1α, VEGF-B, FGF2, and FGFR1 expression levels in the control (SK-OV-3), GEM, oe-NC + GEM, oe-HIF-1α + GEM, and oe-HIF-1α + sh-FGFR1 + GEM groups; E CCK-8 assay measuring the differences in proliferation across groups; F Scratch assay measuring the differences in migration across groups; G Transwell assay measuring the differences in invasion across groups; H Angiogenesis assay measuring the formation of tubular structures across groups.
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PMC9429973
Aims: The aim is to evaluate the outcome of FL pts in maintenance with antiCD20-MoAb during SARS-Cov2 pandemic and how suspension of therapy affected lymphoma outcome and the risk of SARS-Cov2 infection and its morbidity and mortality.
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PMC11471176
Measurement Sample Size (N) = 3 for each time point, x is the time point and y is the fluorescence reading, actual slopes and intercepts were divided by 1000 and rounded to the nearest integer. %
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PMC10606998
The results are presented in Figure 3.
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PMC9243326
.
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PMC5025404
It is known that one disadvantage of this approach is the possible survival of non-expressing clones during selection (Steven et al. 2013; Bardor et al. 2012; Schlatter et al. 2005).
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PMC6222726
The authors found growth inhibition, with IC50 values in the order of 0.05 mg/mL. The ODC activity was inhibited by 12% at 4.0 mg/mL. Gutiérrez-Gutiérrez et al., considering the use in Mexican traditional medicine of B. fagaroides as an antidiarrheic, investigated the in vitro anti-giardial activities of four podophyllotoxin-type lignans from Bursera fagaroides var.
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PMC9429973
Pharmacokinetic (PK) analyses, including Cmax and Tmax of CAR+ T-cell transgene levels in blood are being performed.
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PMC9065483
Furthermore, we consider that this aspect could potentially be exploited to control immune adverse events during oncolytic VSV clinical trials.
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PMC10125312
Uptake (AuNR-PEG/cell) was measured over a fixed incubation time and increasing AuNR concentrations.
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PMC11461025
This decrease in MMP-9 levels in cells treated with isoginkgetin was attributed to a concentration dependent downregulation in the activation of the PI3K/AKT signaling pathway (Yoon et al. 2006) .
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PMC10873328
The prognosis Index of prognosis model was showed in Supplementary Table 1.[12pt] $$ Prognosis\;Index & = ( }\;}\;}\;}} ) + ( \;}\;}\;}\;}1}} ) \\ & + ( }\;}\;}\;}12} ) + ( }\;}\;}\;}1} ) \\ & + ( }\;}\;}\;}2} ) + ( }\;}\;}\;}4} ) \\ $$=0.005*expressionlevelofTGFBI+0.020∗expressionlevelofCDKN1B+0.023*expressionlevelofAKAP12+0.010*expressionlevelofGPC1+0.005*expressionlevelofTGM2+0.017*expressionlevelofANGPTL4Figure 1Prognostic value of the hypoxia risk signature in OC. (
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PMC6799808
However, the molecular mechanism underlying the anticancer action of G. lucidum extracts remains to be investigated.
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PMC11575040
In addition, in the DM group, the OS of the high LINC00094 expression group was shorter after 750 days than that of the low LINC00094 expression group, albeit without statistical significance.
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PMC11389534
The UFM1 system is highly conserved across all eukaryotic organisms, with the exception of yeast or other fungi.
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PMC5941560
Our final comparison to previously identified variants focused on rare, pathogenic variants from the ClinVar database.
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PMC11317131
Different patterns of activity were observed for the combination mutants between experiments performed with and without PE.
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PMC9429973
Nineteen (79%) patients were refractory to their most recent regimen.
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PMC11761919
However, the expression levels of heterologous proteins in host probiotic bacteria remain low, which limiting the application of recombinant probiotic bacteria.
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PMC11248911
for C14H15N3OS (273.35): C, 61.51; H, 5.53; N, 15.37; S, 11.73.
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PMC11541241
To identify the evolutionarily conserved TOR signalling pathway components in fungal pathogens, the amino acid sequences of corresponding components of the TOR signalling pathway for Saccharomyces cerevisiae, Schizosaccharomyces pombe, Homo sapiens, and Arabidopsis thaliana were used to BLAST search for the homologous sequences in the genomes of the 10 fungal pathogens mentioned above (Table 1, Table S1).
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PMC9429973
Aims: We applied a next-generation sequencing (NGS) based method to comprehensively screen for recurrent, disease-relevant CNAs in a cohort of Hungarian patients, allowing us to establish novel patient risk stratification approaches.
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PMC11541241
MoGAP1 deletion affected the conidial development, altered sensitivity to RAP, and increased the level of autophagy in M. oryzae.
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PMC6114978
Mutations in the upstream Hippo kinases, MST1, MST2, LATS1, and LATS2 have also been rare.
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PMC11514418
For elderly patients, impaired physiological function, lower drug tolerance, and chronic diseases may affect the implementation of chemotherapy.
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PMC11794847
These inhibitors work by releasing the brakes on T cells, enabling them to more effectively attack tumors.
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PMC10335954
The downregulation of TRIP13 promoted apoptosis and inhibited tumor growth.
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PMC7504302
Because of its limited expression in normal tissues, mesothelin exhibits high specificity for malignancy.
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PMC5386478
Next, we cultured MSTO-211H cells, for 24, 48 or 72 h, as multicellular 3D spheroids.
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PMC11261875
The author is not an Editorial Board Member/Editor-in-Chief/Associate Editor/Guest Editor for Neoplasia and was not involved in the editorial review or the decision to publish this article.
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PMC9429973
The conformity of the quantitative data to the normal distribution was tested with the Shapiro-Wilk test and graphical examinations.
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PMC9844987
Changes in promoter shape in flies thus likely recapitulates the plasticity in TSS usage across human LCLs, despite apparent differences in core promoter elements, promoter nucleotide content, and regulatory features between flies and humans.
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PMC9429973
Siremadlin (HDM201) is a novel investigational MDM2 inhibitor with single-agent (SA) anti-AML activity.
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PMC10589262
Error bars represent the SD of the mean of three independent experiments.
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PMC10748106
D61 and D62 also present a higher electron density over the hydroxymethyl at C8 (Figure S8I,J).
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PMC9429973
Methods: The inhibitory and apoptotic effect of As2O3 on human MM cells was monitored by a CCK-8 method.
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PMC10170482
Moreover, developed and metastatic tumor tissues possess a high degree of mechanical heterogeneity bearing stiffer edges compared to the core of the tumor.
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PMC11723210
The light beam is transmitted through the objective lens (UPLanSAPO × 20/0.5NA, Olympus, Tokyo, Japan) and recorded by a camera (Imaging Source DMK 23 U274, 1600 × 1200, 4.4 µm).
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