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OTAR3088
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PMC9428827
Tumor size was assessed using a microcaliper every 3 days, and the tumor volume was calculated using the following formula: (width × length)/2.
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PMC9429973
Aims: The aim of this study was to assess the impact of muscle and adipose tissue indexes in patients with CLL treated with targeted agents.
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PMC11638255
c Violin plots of gene expression levels associated with intracellular copper levels (Mt1, Mt2) and neuroblastoma oncogene Mycn, split by treatment group.
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PMC11746942
These findings provide new insights into the molecular mechanisms underlying psoriasis and identify S1PR3 as a promising therapeutic target.
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PMC7553912
In the kidneys of OSMRβ mice on day 3, the expressions of KIM-1, TGF-β, Col1a2, and αSMA were significantly suppressed compared with WT mice (Fig. 3h–k).
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PMC11093197
α‐tubulin was used as a loading control. (
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PMC11522251
Each cell was kept in an incubator set at 37°C, containing 5% CO2.
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PMC9429973
The mutation frequency of TP53 was significantly higher in LDH-high (>244 U/L) group than that in LDH-low (≤244 U/L) group (40% vs. 6.25%, P<0.05).
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PMC11343332
A scratch test was performed to evaluate the effect of pycnogenol on the migration of breast cancer cells.
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PMC11612508
Fig. 7Drug loading efficiency (A) Swelling characteristics (B) and Drug release of magnetic microspheres at various magnetic frequencies (C).
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PMC10652261
As presented in Table 1, compound 2h was more potent on the K562 cell line than bortezomib.
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PMC7823217
Ovarian cancer is the seventh most lethal cancer in women .
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PMC11544771
The next day, after pre-incubation with or without PRE (20 nM) for 2 h, the cells were treated with CPX (0, 5 μM) for 24 h. Then, the cells were trypsinized, washed with cold phosphate-buffered saline (PBS), and stained with the Cellular DNA Flow Cytometric Analysis Kit (Roche Diagnostics, Indianapolis, IN) following the supplier’s instruction.
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PMC11352877
TGF-β1 acts by binding to the ALK1 receptor (TGF-β1 receptor 1, TpRI).
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PMC6600253
In addition, S phase arrest is commonly observed in cells treated with RSV or PT to induce senescence, reflecting that replication stress was induced when replication forks were stalled .
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PMC9429973
Methods: Routine manual technique and column-agglutination technique for blood typing, screening and identification of anti-erythrocyte antibodies (agglutination, enzyme method, direct and indirect antiglobulin test), in vitro compatibility tests on all methods and techniques as necessary.
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PMC8345486
A comparison of the results for compounds 23 and 2 is shown in Figure S6 (Supplementary Materials).
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PMC11666785
The raw data is shown in Supplementary Video 1.
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PMC11665555
A diverse BCa cell panel helped support the correlative findings in patients whose HMGCS2 loss and OXCT1 gain were consequential to establishing gemcitabine resistance.
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PMC9429973
On this basis, to validate this protocol, we regisrered a voluntary single-arm, prospective multi-center clinical study in China.
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PMC11040965
The role of other molecules in influencing the reduction of miR29b could not be ruled out.
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PMC11769516
The results showed a significant improvement in cell viability in the strategy of pre- and co-treatment with Voghiera garlic extract (VGE), especially in the case of co-treatment with β-ZEL and then with α-ZEL and BEA.
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PMC11739504
After 24 h, cells were incubated under serum starvation conditions, followed by staining with endogenous acetylated α-tubulin for primary cilia (red) and pericentrin (PCNT) for centrosome and basal body (yellow).
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PMC11604768
Next, to replicate the promoter sequence of our TRE-minTK screening plasmids, annealed oligonucleotides containing restriction enzyme recognition sites were ligated to pGL4.R_minTK digested with KpnI (pGL4.R_TRE_minTK).
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PMC11740399
To examine the relationship between PMK2 and lipid metabolism, PMK2 and FASN were detected by western blot (Fig. 4D and E).
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PMC11476106
Since VN cross-linking increases matrix stiffness, promoting migration and proliferation , we hypothesized that cross-linking VN to the HGs would activate more mechanotransduction pathways in cells through ECM–cell interaction .
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PMC11489275
A, B The survival rate of patients within one month in different lymphocyte groups was obtained by log-rank test.
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PMC10729469
Reactive astrocytes were assessed by evaluating GFAP expression.
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PMC9429973
In the pediatric cohort, 8/24 (33.3%) pts had been regularly transfused and 16/24 (66.7%) had not.
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PMC11711871
Intraarterial blood pressure and heart rate were recorded between 2 and 4 pm as previously described .
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PMC8992508
Several models have been proposed for the efflux mechanism, as the “alternating site” model, the “switch” model, and the “constant contact” model, based on the biochemical and structural data obtained by multidrug resistance pumps of prokaryotes (Sav1866 from Staphylococcus aureus, MsbA in gram-negative bacteria) and eukaryotes (P-gp, MRP1 and TAP).
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PMC11546117
Breastfeeding is associated with health benefits for mothers and infants.
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PMC11406030
Using Microsoft Excel, a plot of the relationship between the increasing concentration of the labeled peptide with a fixed amount of protein was constructed, and the Kd was extrapolated from the tangents. (
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PMC11599565
HERV3.1 was also upregulated in cisplatin resistant cells.
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PMC11638255
The analysis consisted of two main steps: Gene Set Enrichment Analysis (GSEA) using the fgsea function and Over-Representation Analysis (ORA) using the clusterProfiler package.
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PMC8345486
Sterile DMSO for cell freezing medium was purchased from BioSchop Canada Inc. (Burlington, ON, Canada).
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PMC7961460
Therefore, we cultured the epithelial breast cancer cell line 8701-BC, an estrogen receptor negative (ER-) with intermediate aggressiveness cell line derived from a primary ductal infiltrating carcinoma , in their specific M199 medium.
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PMC9429973
The safety run-in will evaluate safety across 2 siremadlin dose levels (20 or 30 mg) from Day (D)1 to D5 in each 28-d treatment cycle in combination with venetoclax and azacitidine.
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PMC11682224
This vesicle-depleted fetal bovine serum was used for cell culture.
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PMC11476264
Human lung adenocarcinoma cell line H1299 cells were grown in RPMI-1640 (Gibco) with 10% FBS.
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PMC11737091
Almost 30% of patients have metastases at the time of diagnosis of ccRCC because some ccRCC patients are asymptomatic .
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PMC9429973
T cell-mediated activity was assessed using an engineered Jurkat T cell line, and in TDCC assays with primary healthy donor T cells.
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PMC5311252
Sequencing indexes and miR-Vec sequences were segregated and deconvoluted from each sequencing read.
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PMC9429973
Enhanced pharmacovigilance (PV) was performed for four weeks following the first induction course.
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PMC8751435
Consistently, cell bubbling is induced by CME in our research.
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PMC11317131
By pre-inserting the att site into cell lines, hyperactive integrases could mediate highly efficient gene insertion to a single known locus.
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PMC11538390
Data are represented as mean values +/− s.d.
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PMC11583010
As indicated, the DAR was stable up to 48 hours (7.8) and started to decrease by 72 hours (7.3) to 5.9 by day 7 and 5.2 by day 15.
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PMC11754436
Cells in the mimic NC group (mNC) underwent the same treatment without miR-362-5p overexpression.
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PMC11612794
Quantification of GFP-Dsn1 signals at kinetochores in mitotic cells shown in (A).
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PMC11615828
The enlarged mean speed trajectories of LAMP1‐mCh‐Cry2‐labeled lysosomes before, during, and after light stimulation in light‐illuminated and non‐stimulated regions, are shown.
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PMC11721064
However, the expression of ΔNP63α did not significantly differ between P0 SKCs and P1 SKCs.
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PMC9429973
During 2 lockdown only 68 diagnoses were captured (Q4 2020/21 – 74% of the Autumn/Winter average).
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PMC9429973
Positive bacterial cultures from venous blood were detected in 92 cases, and 12 blood probes of them had mixed infection (2 or 3 bacterial pathogens).
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PMC7351993
To evaluate the sort yield and purity of sorted cells, we constructed a centrifugation-based cell counting device.
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PMC5925824
Finally, LY3300054 was also shown to enhance T cell activity in the tetanus-toxoid recall assay (TTRA) which measures the ability to stimulate antigen-specific memory T cells in PBMC. (
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PMC11612626
Effect of compound A on proteasomal catalytic activities.
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PMC5854676
The Raman spectra were gathered in the 50–4000 cm range.
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PMC11732635
We determined the lymphocyte subtypes of EBV infection by fluorescence quantitative polymerase chain reaction and the expression of EBV envelope glycoprotein 350 (gp350) in peripheral blood lymphocytes.
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PMC10454535
BTZ as well as RES and its derivatives pinostilbene (PIN) and piceatannol (PIC) decreased MM cell viability in a dose- and time-dependent manner and increased expression of cleaved proapoptotic proteins poly(ADP-ribose) polymerase 1 (PARP1) and caspase-3 in a dose-dependent manner.
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PMC11599565
The EpCAM negative cells, which have a stemness/neuronal phenotype revealed no expression of MGMT whereas the EpCAM positive cells (epithelial) exposed an upregulation of this enzyme.
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PMC7987994
DMEM also contains additional non-essential amino acids which are missing in MEM.
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PMC10006224
For calibration, 5% of chromatin from mouse ES cells was added to the human chromatin.
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PMC10748106
Figure 12 displays the descriptive and predictive ability of the QSAR model, according to the squared regression coefficient (R)–that corresponds to the value of the explained variance in the description and the prediction (Q)–our model has an acceptable ability to predict biological activity.
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PMC11337594
This process can be likened to the flow of water in a river.
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PMC11787651
This instrument is also designed to excel at analytical flow rates without losing quantitative sensitivity, enabled by the Zeno-trapping technology (51, 52, 53, 54, 55, 56).
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PMC9532503
The binding affinity of the test anti-CD20 antibody (P2-CRD-1508) and the control antibody samples (RS-03-25) for FcγRIIIa receptors V158 and F158 (Acro Biosystems, USA) was determined by the SPR method using Biacore T200 (GE Healthcare, USA) as per manufacturer’s recommendations using immobilized anti-histidine CM5 sensor chip (GE healthcare, USA) and His-tagged FcγRIIIa receptors.
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PMC11342785
We sought a nonessential condensate-regulatable MAP with a simplified domain architecture that could provide a starting point for assembling and exploring synthetic MT architectures from the bottom-up.
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PMC10607604
We developed isogenic clones of OVCAR-8 cells that overexpress PTPN13 using the Flp-In system, and KURAMOCHI cell clones that do not express PTPN13 using the CRISPR-Cas9 method (Figure 2A).
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PMC11683240
For this, three different approaches were used, (i) mutate all residues simultaneously to alanine, (ii) cluster-based mutations: residues were separated into specific clusters and mutated each cluster, (iii) individual mutations.
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PMC11742047
Putative annotated features of both cell lines and both polarities were reprocessed using MassHunter Workstation Profinder software, version B.10.0.2 (Agilent Technologies, Santa Clara, United States) to clean the background noise and unrelated ions.
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PMC9429973
Participants were satisfied with the preparatory course enhancing their role preparation as peer supporters and 14 caregiver ambassadors attended the available support network meetings (n = 6).
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PMC7053076
The human leukemia cell line, HL-60 was purchased from the European Collection of Authenticated Cell Cultures (ECACC) and was cultured in RPMI 1640 plus GlutaMax I medium (Invitrogen, Grand Island, NY, USA) containing 10% fetal bovine serum (FBS) and antibiotics (100 μg/mL streptomycin and 100 U/mL penicillin).
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PMC10728200
Subsequently, correlations between STUB1 and GPX4 expression and clinicopathological features in the 418 patients with GIST were analyzed.
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PMC9429973
Fine-Gray and Cox proportional hazards regressions were fitted, and corresponding Kaplan-Meier curves computed.
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PMC11803149
Thus, it is possible that age-related downregulation of E2F is responsible for decreased expression of Epas1 in aged CD8 T cells.
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PMC2196094
Filters were washed at low or medium stringency (6× SSC, 0.5% SDS or 2× SSC, 0.5% SDS).
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PMC4369959
According to Indian Ayurvedic medicinal system, ginger is recommended to enhance the digestion of food .
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PMC6181431
Alternatively, tumor heterogeneity or sampling issues may account for these PBRM1 mutations seen only in the post-treatment samples.
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PMC5673955
In this report, we demonstrated that the immortal phenotype of blood cancer cells Jurkat can be reversed by continuous exposure to RrA. A potential side effect that could limit the clinical value of RrA due to its possible activity against normal telomerase‐positive cells such as proliferating lymphocytes.
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PMC11388384
In primary limb tissue, SHH-Halo diffused in four discrete populations with similar diffusion rates compared to SHH-Halo diffusing among NIH3T3 mouse embryonic fibroblasts, suggesting diffusion as discrete membrane-confined and membrane-unconfined populations is a natural feature of SHH (Fig. 2F).
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PMC5535901
Total protein was extracted in a lysis buffer (RIPA) containing protease and phosphatase inhibitors for preparation of whole cell lysates by centrifugation at 14,000 rpm at 4 °C for 15 min.
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PMC9599726
YAP is located downstream of the Hippo pathway, which responds to diverse stimuli including cell–cell interaction, cellular stress, extracellular signals, cell polarity, and mechanical signals .
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PMC11748618
Table 1Genetic variants in the chromosome 1 region with the strongest association to HIV set-point viral load in a multi-SNP model using BIMBAM.VariantHIV spVL BetaHIV spVL P-Valuer to rs59784663rs72999655-A-G− 0.309.09 × 100.99rs7525622-G-A− 0.213.98 × 100.46rs73004025-C-T− 0.296.36 × 100.90Direction corresponds to the effect of the minor allele.
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PMC9872547
The reaction was accomplished at 25°C for four hours.
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PMC11604830
The first demonstration of possible in vivo application of H‐CSI using PFCE‐NE was obtained by direct intratumor injection of PFCE‐NE followed by H‐CSI of the tumor, displaying a clear accumulation of the nanoemulsion in the tumor rim.
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PMC3203927
The focus on cytokines in this study was based on previous proteomic and transcriptomic evidences from other 3D culture studies indicating that cytokines' expression levels are altered by culture conditions –. The list of cytokines analyzed was obtained from the Immunology Database and Analysis Portal (ImmPort) (https://www.immport.org/immportWeb/queryref/geneListSummary.do).
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PMC9429973
Tolinapant is a potent, non-peptidomimetic antagonist of cIAP1, cIAP2 and XIAP.
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PMC4360730
For example, we have begun working with the developers of the CL to define rules that can help automate identifying and validating ontology relationships between new and existing ontology terms.
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PMC11518702
HGAL promotes DLBCL and Burkitt lymphoma cell line tumorigenesis—in vivo outcomes of xenograph studies (NOD/SCID mice) are summarized.
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PMC2193049
Analysis of the enzymatic activity of the proteasome in the presence of the proteasome inhibitor supported this discrepancy.
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PMC9429973
9 FL pts (60%) were ≥80 and 5 (30%) 70-80 years.
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PMC9429973
Several components of different DNA repair pathways have been recently identified to play critical role in ALL pathophysiology and drug resistance.
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PMC11802929
We perform GLIPH2 analysis on SARS-CoV-2 specific TCRs identified in this study that assigned with antigen specificity, and TCRs from the longitudinal dataset with unknown antigen specificity.
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PMC11543885
For complete details on the use and execution of this protocol, please refer to Liang et al.Defining the molecular environment of dynamic protein interaction networks at a molecular level is experimentally challenging due to frequent weak and transient interaction stoichiometries between proteins, adaptor molecules, enzymes and substrates.
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PMC11126803
Furthermore, we mutated this key sequence of ERE#2 and replaced it with the BamH1 restriction site, then inserted the WT promoter and the mutant promoter region of ZEB1 into the pGL3 luciferase plasmid (Fig. 5E) sequences are shown in Fig. S7, A–C. As we expected, luciferase reporter assay results revealed that overexpressing ERβ in the A498 cells led to increasing the luciferase reporter activity in WT, but not the ERE-mutated promoter (Fig. 5F).
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PMC6461034
For tumor biopsy phosphoproteomics in this study, needle biopsies from a patient with advanced head and neck squamous cell carcinoma, obtained in an Institutional Review Board‐approved molecular profiling study before and after 2 weeks of treatment with erlotinib (NCT clinical trials identifier 01636908; www.clinicaltrials.gov), were processed as described elsewhere (Labots et al, 2017).
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PMC11541241
Targeted mutagenesis of the pathogen TOR pathway may result in the inhibition of fungal development and pathogenicity.
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PMC11222184
HSP27 is known to perform a cytoprotective effect by directly suppressing cell death via interactions with key proteins in the apoptotic cascade .
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PMC11033180
The distribution of synapsin 1 was assessed by immunofluorescence (F) and the number and size of synapsin 1 clusters were measured (D and E).
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