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OTAR3088
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PMC9895440
All results unless indicated show integrated fluorescence area on a biexponential scale.
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PMC9429973
Josip Benčević, Slavonski Brod; School of Medicine, University of Osijek Josip Juraj Strossmayer, Osijek; Internal medicine department, General Hospital Šibenik- Knin county, Šibenik; Research Department, University Hospital for Infectious Diseases “Dr Fran Mihaljevic”, Zagreb; Microbiology Department, Institute of Public Health Osijek-Baranja County, Osijek; Department of Infectious Diseases, General Hospital dr.
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PMC11607764
Importantly, PTBP1 is abnormal in a variety of human cancers.
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PMC8662250
In theory, thus, the restoration of the mucosal permeability exerted by CBD would allow a possible inhibition of a pathway involved in the amplification of the SARS‐CoV‐2 infection toward the lung or CNS (Peyravian et al., 2020), beneficially impacting the clinical worsening and severity of COVID‐19 course observed in so many patients.
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PMC11632064
The RNA concentration was determined using a Varioskan LUX multimode microplate reader (Thermo Fisher Scientific) with a μDrop plate (Thermo Fisher Scientific).
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PMC11634794
However, it was not related to N stage, gender, age and other factors (all P values> 0.05).
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PMC11451829
A prospective study by Mushtaq et al., in which pterygium samples were collected after resection, revealed a correlation between lesion size and inflammation grade.
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PMC11767817
Moreover, Jiang and co-workers reported that MK-2206 at a dose of 5 µM effectively decreased Akt phosphorylation in 5637 cells after 15 h of incubation .
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PMC10522430
This treatment was executed across six replications.
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PMC11794847
Thus, in mechanistic terms, HVEM directly decreased FOXA2 expression which acted as the upstream transcription suppressor of GPT2.Fig.
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PMC11367146
Thirteen active components of Vanda tessellata were identified from the literature and the IMPPAT database.
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PMC2193049
After 20 min, the reaction was stopped by the addition of 5% TFA and lyophilized.
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PMC11711345
However, no compound decreased cell viability (≥ 97%) significantly (p ≥ 0.99, post-hoc Dunnett´s test) for HEK-293 and Caco-2.
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PMC11472639
Haemodynamic variables pre-exercise, post-exercise, and 30-min post-exercise with percentage change (%Δ) pre-to post-exercise and main effect from one-way repeated measures ANOVA in smouldering multiple myeloma.
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PMC11675244
The development of therapies that target CSCs and bulk tumors is both crucial and urgent.
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PMC9429973
Subsequently, T cell response was evaluated using a fluorospot assay assessing IFNg/IL-2 secretion upon re-exposure to S peptides (Mabtech).
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PMC9429973
Pts with B-cell recovery (<6 mo, n=10; 6-12 mo, n=4; >12 mo, n=7) experienced a 2y cumulative incidence of relapse of 25.2% (with SCT treated as a competing risk).
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PMC11711345
Several studies on p-cymene (4-isopropyltoluene, Compound 1 in Figure 1), a monoterpene with a p-menthane skeleton hydrocarbon structure, have reported its significant in vitro activity against specific cancer cells [1-3].
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PMC11472639
indicates a significant difference from post-exercise at p < 0.01.
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PMC9436459
Sanggenon G (124) had a certain inhibitory effect on influenza A virus (IC50 = 30.9 μM) .
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PMC8973085
Probit analysis was used to determine the IC50 values (IBM Corp., Armonk, NY).
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PMC10538569
The average values ± standard deviation (SD) are shown.
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PMC9429973
Consistently, a marked synergistic therapeutic response was found between the DNA damaging drug etoposide and the BCAT specific inhibitor ERG245 in numerous T-ALL models.
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PMC8750422
Compared to the LPA-treated cells, treatment with L-NAME notably reduced the LPA-induced intracellular NO production (Figure 4e).
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PMC11525028
Among the candidate target genes of ATF4, ASNS was found to be downregulated in both cell lines (Figure 4A).
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PMC11401350
In contrast to pan T cell targeted CARs such as anti-CD7 CARs, the CD8 T cell population is not targeted in our CAR therapy and their persistence might decrease the risk of infections compared to other total T-cell directed CAR strategies.
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PMC11785489
Consistent with other numerical representations of the TCR, we translated each amino acid residue in both the α and β chains of the TCR into five Atchley factors.
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PMC9429973
Summary/Conclusion: Molecular profiling of KMT2A-rearranged AML in Russian Federation reveals the highest incidence of KMT2A-MLLT3 fusion gene and KMT2A intron 9 involvement.
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PMC9454178
The tumour inhibitory effect of THZ1 in vivo was assessed in a subcutaneous xenograft model of GIST-T1.
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PMC10818573
The target bands were weakly amplified when the amplification system contained nfo buffer, but the target fragments could be amplified under other conditions (Figure 2D).
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PMC11423992
This unique feature makes CD20 an optimal target for therapeutic antibodies in tumor immunotherapy.
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PMC9368503
Here, we present and characterise a new synovial sarcoma cell line ICR-SS-1, which has been established from a PDX model held in The Jackson Laboratory biorepository.
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PMC3164356
The two most abundant sialic acids are Neu5Ac and Neu5Gc.
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PMC11530949
The observed ROS level in the nanoparticle-treated group was approximately 1.5 times higher than that in the extract-treated group. *
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PMC10291556
Therefore, it was attractive to test whether the new Pt(IV) prodrugs 2–4 could stimulate biochemical processes characteristic of ICD.
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PMC11204465
It is a class of compounds containing a difuran ring and coumarin (oxonaphthoquinone) in their basic structure.
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PMC9429973
To identify high-confidence MDS variants, we attributed an internal deleteriousness score to define variants, from “of uncertain significance” to “pathogenic” (ACMG guidelines).
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PMC11753435
Notably, SS_PpC_4 peptide overexpression led to a strong reduction in SS18-SSX1 protein levels (>40%) as assessed by immunoblotting with a fusion-specific antibody (Fig. 5C).
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PMC9910796
According to its predicted topology, most of its C-terminal half, which contains two 21 aa-long hydrophobic α-helical segments, would be embedded in the lipid bilayer while the N-terminal half (30 aa) and a short (4 aa) C-terminal tail would face the cytosol (Fig 1B). (
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "According", "to", "its", "predicted", "topology", ",", "most", "of", "its", "C-terminal", "half", ",", "which", "contains", "two", "21", "aa-long", "hydrophobic", "α-helical", "segments", ",", "would", "be", "embedded", "in", "the", "lipid", "bilayer", "while", "the", "N-terminal", "half", "(", "30", "aa", ")", "and", "a", "short", "(", "4", "aa", ")", "C-terminal", "tail", "would", "face", "the", "cytosol", "(", "Fig", "1B", ")", ".", "(" ] } ]
PMC6799808
Representative images of the flow cytometry results are shown in (f), and the quantitative data are presented in (g).
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PMC11791478
The data on 25A3 reported here confirm and expand on these prior findings (16).
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PMC10142392
Depending on the topology, micellar structures can include sphere, lamella, worm-like, and disk shapes .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Depending", "on", "the", "topology", ",", "micellar", "structures", "can", "include", "sphere", ",", "lamella", ",", "worm-like", ",", "and", "disk", "shapes", "." ] } ]
PMC10578720
Second, the present study focused on TCA cycle dysregulation in HBV-induced M2-like polarization.
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PMC11641630
M. bovis BCG Connaught (ATCC 35745) and M. brumae (ATCC 51384T) were grown on Middlebrook 7H10 medium (Difco Laboratories, Detroit, MI, USA) supplemented with 10% oleic acid-albumin-dextrose-catalase (OADC) enrichment for 3 weeks and 1 week, respectively, at 37 °C.
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PMC8973725
Ectopic expression of ZNF677 suppresses invasion and EMT of 786–0 cells through the inactivation of the PI3K/AKT signaling pathway. (
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PMC7351993
ImageJ (NIH) was used to produce colored images and merged images shown in Fig. 2b, Fig. 3, Fig. 4b, Fig. 4d, and Fig. 4 f from the decomposed images.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ImageJ", "(", "NIH", ")", "was", "used", "to", "produce", "colored", "images", "and", "merged", "images", "shown", "in", "Fig.", "2b", ",", "Fig.", "3", ",", "Fig.", "4b", ",", "Fig.", "4d", ",", "and", "Fig.", "4", "f", "from", "the", "decomposed", "images", "." ] } ]
PMC7961460
Considering the role of HA in tumour progression, it is known that MDA-MB-231 cells synthesize constitutively high amounts of HA .
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PMC8992508
Compounds 107, 108 and 109 are triple inhibitors with IC50s in the single-digit micromolar range.
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PMC11461874
After being gently mixed at 4 °C for 1 h, the suspension was centrifuged (18,000 × g for 30 min), and the supernatant was used as the nuclear fraction.
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PMC11747467
Immunostaining for luminal markers (GATA3 and KRT20) and basal markers (KRT5/6 and CD44) was performed on 100 MIBC samples to identify luminal and basal bladder cancer subtypes (17).
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PMC10092581
Briefly, H157 cells (8×10 per well) were seeded in 96‐well plates; after 24 h, cells were washed with PBS and loaded with Mito‐ID Detection Reagent for 30 min at 37 °C in the dark.
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PMC9119314
Solutions of 3–6 were concentrated using a rotary evaporator and crystallized at −18°C for 24–48 h. H-NMR spectra at 400 MHz and C NMR spectra at 100.6 MHz and correlation experiments were acquired using a Bruker DP 400 MHz NMR spectrometer.
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PMC10808409
The in-vitro release of FA from O1 and O2 was studied adopting the dialysis method.
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PMC11794847
Fig. 2Activated T cells can suppress the malignant biological behavior of NSCLC cells.
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PMC10079526
K Bar-graph visualizes Gene Ontology enrichment analysis of proteins SUMOylated upon 20 h of 5-Aza-2’ treatment, for GO molecular functions.
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PMC10747160
After cells had recovered, the 96-well plate was retrieved from the incubator, and the media were gently pipetted out of wells.
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PMC9917080
The concentration of sorafenib colloidal solution is 30 mg/mL. The concentration of nanoparticles is 10 mL. The citrate buffer had a molarity of 0.1 M. The average particle size was measured using dynamic light scattering (DLS) and transmission electron microscopy (TEM) methods.
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PMC11621565
LPS is the endotoxin of Gram-negative bacteria.
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PMC5386478
TG2 catalyses the Ca-dependent post-translational modifications of proteins by introducing covalent bonds between free primary amine groups and peptide bound glutamine residues.
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PMC11770199
Therefore, we propose introducing a novel cell-killing mechanism, cell–cell fusion, to develop an antitumor cell therapy aimed at broadly and distantly killing tumor cells, thereby improving therapeutic efficacy against solid tumors.
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PMC11448304
a Immunoprecipitation results of overexpression of EGFR wild-type (WT) and lysine 716 to arginine mutation (K716R) in HEK293T cell line, respectively.
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PMC11727145
Sample collection began when the patient was first admitted to the burn center, and a negative pressure dressing was used to collect fluid into a reservoir bottle.
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PMC11591038
Salidroside also promoted the secretion of sAPPα in hypoxic condition without affecting APP, ADAM10, and ADAM17; the latter two are considered α-secretases, suggesting that heightened sAPPα secretion may be the consequences of decreased β-secretase activity.
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PMC10748106
Finally, we include a third set of three iridoids, which are derived from glycosylated iridoids (D60-D62), that have shown inhibitory activity against Taq DNA polymerase .
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PMC10142392
As their capacity can be adapted, the encapsulation and controlled administration of drugs in self-assembled structures should be more versatile .
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PMC11437637
The data were compared using a t-test or a Mann-Whitney U test for normally distributed and non-normally distributed data, respectively.
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PMC9429973
Summary/Conclusion: The datasets generated from these models enable deeper insights into the epigenetic and transcriptomic changes that depend on CEBPA and TET2 mutations in a physiologically relevant mutational context.
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PMC11656048
Shikonin is a kind of active ingredient extracted from comfrey, which has many pharmacological activities such as anti-inflammation and potent anti-cancer activities.
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PMC11787381
BRET curves and area under the curve (insert) are presented.
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PMC6222635
Then, 50 g of the powder was weighed, 500 mL of petroleum ether was added to remove the lipids, and 500 mL of 80% ethanol was added to remove low polarity substances.
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PMC10698968
Similarly, Tsuchiya et al. tested cell viability after exposure to different concentrations of doxorubicin in five MFS-derived cell lines .
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PMC11756514
MBL and SP-D are soluble highly oligomerized proteins ( Figure 1A ); thus, multivalency is especially important for their efficient binding.
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PMC11476004
Only sex chromosomes have two arms, while autosomal chromosomes are acrocentric.
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PMC10523483
Cells were transfected with indicated plasmids using Lipo3000 (Invitrogen).
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PMC11694066
Here, we show that preclinical models of DSRCT are selectively sensitive to clinical PARPi and ATRi.
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PMC11790971
To compare the cell line classification of different passages, the same number of cells (i.e., 2915 cells) were randomly sampled from passage 0, passage 1, and passage 2, individually.
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PMC11357960
Patients were enrolled from conventional treatments at the First Hospital of Jilin University, Changchun, China, from January 2023 to December 2023.
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PMC11352666
Membranes were stripped and reprobed for total protein or loading control.
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PMC11394112
Although the second-week bioluminescence imaging confirmed DLBCL cell engraftment, the mice were continuously imaged once a week.
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PMC10914904
It has been proposed that small fragments derived from vtRNAs are involved in neurodevelopment.
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PMC3730428
Cellular IAP 1 (cIAP1), cIAP2 and X-linked IAP (XIAP) are the cellular targets for SMAC mimetic compounds (SMCs), which mimic the functions of the endogenous IAP antagonist SMAC.
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PMC10891340
Based on above experiment, 20 μM CCCP was selected as the main working concentration for research.
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PMC9429973
The most common reasons for dose modifications were DS 12(19%), QTc prolongation 10 (15%) & hepatotoxicity 8 (12%).
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PMC11321678
To fill those gaps, here, we performed single‐cell Assay for Transposase‐Accessible Chromatin sequencing (scATAC‐seq) on 11 frozen MB samples of varying ages and mapped the chromatin accessibility landscape of 59015 cells.
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PMC10565698
P < 0.05 indicates statistical significance.
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PMC11323699
c Evaluation of TAX2 biodistribution in healthy C57BL/6 J mice using FMT after IV administration of a dose range of TAX2-Cy5 (1, 5, 10, or 20 mg/kg, 2–6 mice/group).
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PMC9429973
Summary/Conclusion: The national multicenter study allowed characterization of HL in patients with HIV and evaluation of the efficacy of first-line therapy, which was found to be lower than in the general population.
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PMC11723947
Source data are provided in the Source data file.
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PMC8143558
were extracted with a range of solvents before being tested for their hemolytic activity.
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PMC11257988
Meanwhile, Zhou et al. discovered an effective, selective, biologically stable, and cell-permeable peptide drug, NKTP-3, which targets NRP1 and KRASG12D.
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PMC10656496
Unexpectedly, eliminating glutamine reduced the sensitivity of 143B cells to treatment (Fig. 4).
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PMC10344560
Eight patients out of 11 cases reported with Rhodotorula peritonitis in PD patients were treated with Amphotericin B. We did not use Amphotericin B due to its nephrotoxic effect and intravenous administration, while our patient was stable therefore no need for the hospital stay.
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PMC11470381
Figure 5.Measuring live-cell polarity of Piezo1 mCherry and actin-GFP in chemokine-stimulated Jurkat cells.
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PMC11321678
The cells were allowed to form spheres for 7–10 days or until fully formed spheres were observed in the control group.
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PMC11730320
500 ng of RNA was used to synthesize cDNA using Superscript IV Vilo master mix (Invitrogen cat# 11756050) and 100 ng of cDNA from the patient and control, was used for PCR of PTCRA using the following primer pairs: Exon 1 to Exon 4 (Ex1-4) fwd 5ʹ -CCGGTACATGGCTGCTACTT-3ʹ, Ex1-4 rev, 5ʹ -AGGTCAGGAGCAGGTCAAAC- 3ʹ and Exon 2 to Exon 4 (Ex2-4) fwd 5ʹ -CTGGATGCCTTCACCTATGG- 3ʹ, (Ex2-4) rev 5ʹ -AGGTCAGGAGCAGGTCAAAC-3ʹ. GAPDH PCR using cDNA from the patient and control was used as an internal control for the cDNA.
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PMC11583010
Concentration and the dye to antibody ratio were calculated at A280 and A532, as recommended.
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PMC9261184
Methane emissions contribute 35% of the total GHG using GWP100.
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PMC9727330
Oligonucleotides sequences used for mRNA Quantification of Indicated Genes Cell Viability Rate of Treated Caco-2 Cells ¥, DMSO; *, Indicates significant P values ≤ 0.05; **, Indicates high significant P values ≤0.01 Cell Viability and Cytotoxic Effect of Asp and NNDAsp Treatment. (
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PMC9429973
Unprecedentedly in AML, maintenance treatment with Oral-AZA was associated with significantly longer overall survival and relapse-free survival compared with placebo.
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PMC10761571
Due to the strong oxidation potential, the generation of ROS can damage cell structures leading to protein oxidative carbonylation, lipid peroxidation, nucleic acid breakage, and destruction of membrane structure .
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