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OTAR3088
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BioData-CellLine_annotated

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PMC11754094
The canonical ABE (ABEmax) had a large-deletion frequency maximum of 1.42% but the large-deletion frequency was slightly reduced when UGI was added to ABE, with maximum frequency of 0.89%.
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PMC11144200
CD8 T cells cultured without DC/tumor fusion vaccine as the T cells group.
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PMC11626627
The plate was placed in a 37 °C incubator.
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PMC7342409
Despite the finding of ubiquitous MAPK activation in primary GISTs and GIST cell lines, targeted inhibition of MAPK with a MEK1 and MEK2 inhibitor (U0126) had inconsistent effects on GIST cell line proliferation (5–40% inhibition) and did not induce apoptosis.
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PMC11756514
When cultivated in THB, none of the three serotypes produced detectable amounts of CP ( Figure 2B ).
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PMC9792775
In existing studies, the endogenous mitochondrial apoptotic pathway, the most important apoptotic pathway, has been demonstrated by increasing the disruption of caspase-3 protein or by inhibiting the level of Bcl-2 protein (Wang et al., 2019).
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PMC11127909
Specifically, 143B and 143BR cells were seeded in six-well plates and cultured overnight.
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PMC11496728
As shown in Fig. 4A, knocking out the Apaf1 gene in CHO cells had no effect on cell growth compared with the cell density of wild-type CHO cells.
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PMC10047551
We used clustered regularly interspaced short palindromic repeats-associated protein 9 (CRISPR-Cas9) to modify PD-L1 genetic contexts and endonuclease deficient Cas9 (dCas9) fusions with ten-eleven translocation methylcytosine dioxygenase 1 (TET1) and DNA (cytosine-5)-methyltransferase 3A (DNMT3A) to manipulate PD-L1 DNA methylation.
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PMC9684669
Notably, in resistant cells, the synergy score reached 49.80 when resistant cells were treated with 3.33 µM terfenadine and 1.11 µM doxorubicin, which was higher than the highest score of 22.39 in sensitive cells, showing a greater synergistic effect in MDR cells than in their parental cells, indicating that terfenadine will target the abnormally activated pathway associated with ABCB1 overexpression in MDR cells.
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PMC8992508
In this paper, both selective BCRP inhibitors and dual P-gp/BCRP inhibitors reported in the literature in the last five years were analysed and reviewed.
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PMC11548041
The 3D folded structures of the seed aptamers were generated using the 3dRNA/DNA server (Xiao Lab) .
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PMC9429973
The best therapeutic strategy for PVRL without CNS involvement remains undefined due to the paucity of high-quality trials in this rare disorder.
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PMC11063646
The utilization of nanotechnology in dermatological formulations offers a promising platform for topical drug delivery.
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PMC11786704
2Cell viability and ROS scavenging capacity of PC capsules. (
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PMC10243817
In addition, we found an upregulation of mRNA expression of TGFBR1 and TGFBR2 in nasal epithelial cells from patients with CRSsNP, but no change was found in epithelial cells from patients with eosinophilic or noneosinophilic CRSwNP, compared with controls (Supplemental Figure 8).
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PMC8427838
Cell migration was carried out using Boyden Chamber assay as previously described .
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PMC9429973
The criterion for the neutropenia was the absolute number of neutrophils less than 1.5 thousand in 1 μl of peripheral blood.
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PMC7759933
Evaluation of the spheroid growth was determined three times independently.
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PMC11725127
It can be observed that USP2 knockout resulted in cell proliferation inhibition and increased cell death, as evidenced by the decrease of Ki-67-positive and increase of TUNEL-positive cells, respectively.
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PMC10178190
Results shown in Figure 3D indicate that SuPAR (soluble receptor), IL-6, and hepatocyte growth factor (HGF) were enriched in the active CM, and they correlate with chemoresistance induction.
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PMC9429973
Several studies observed that differences in blood groups may be linked to COVID-19 susceptibility and clinical outcomes; however, the results are controversial and there is a need for further research and validation.
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PMC11204465
The discovery of AF came about as a result of the first occurrence of “Turkey X Disease” (the cause of which was unknown at the time, hence the name) in 1960 in a suburb of London, England .
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PMC11792766
The novelty of this study lies in its comprehensive analysis of the compatibility and limitations of organic solvents in regulatory food simulants and their impact on the performance and efficiency of in vitro biological screening.
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PMC9429973
Results: In band 4.2 mice, splenectomy resulted in (i) amelioration of anemia with reduced reticulocyte count (Hb 13.3 ±0.5 g/dL, n=3 vs 11.9±0.6 g/dL, n=8; P<0.05; retics: 4.9±0.5%, n=3 vs 10.0±1.4%, n=8 P<0.05) and reduced hemolytic indices (LDH, total bilirubin) when compared to non-splenectomized 4.2 mice.
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PMC9429973
Summary/Conclusion: Consistent with the high expression of HES6 in MEPs, we observed significantly reduced cell proliferation upon HES6 knockdown during erythroid/mekaryocyte differentiation, with the most distinct effect on erythroblasts.
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PMC11697703
This coordination is critical to establish the distinct inputs, outputs, and therefore the distinct functions of each neuron subtype.
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PMC11055510
The results of CCK8 showed that the OD value in the si-IL1RAP group was significantly lower than that in the si-nc group at 72 h. The OD value in the si-IL1RAP+inhibitor group was significantly higher than that in the si-IL1RAP+inhibitor nc group (Fig. 8B).
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PMC6642070
Statins inhibit the rate-limiting enzyme, HMG-CoA reductase (HMGCR), in the cholesterol synthesis pathway.
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PMC9516447
These results indicate that the reduction in KRAS expression is not at the transcript level.
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PMC10421378
This damage can expose inner components or disrupt the integrity of the cell surface, affecting the interaction between probiotic cells and Caco-2 cells.
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PMC11791203
One of the modalities for cancer treatment is to induce apoptosis in cancer cells.
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PMC9031474
9-epipolygodial (49) shows high antiproliferative effects against several cancer cell lines.
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PMC11033180
We found that 49.8 ± 8.4%, 12.4 ± 6.5%, and 16.0 ± 4.1% of total Plexin A2 neurons also express ChAT, nNOS, and calbindin, respectively.
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PMC11519583
Consistent herewith, treatment with SB203580, a specific inhibitor of p38 , resulted in a significant suppression of Wnt5b-induced proliferation of MPs (Fig. 3f).
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PMC10900886
Susceptibility and permissiveness of B cell-rich models to EV-D68 infection.
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PMC11745600
These mice have been widely used in regeneration medicine for the xenotransplantation of human embryonic stem cells or induced pluripotent stem cells and in transplantation experiments involving tumor cells.
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PMC11791264
A2780 and SKOV3 cells (3–5 × 10) were inoculated in 12-well plates and cultivated for the allotted time.
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PMC9429973
The difference between the two is that in the first model, the nurse usually goes to the patient’s home on a daily basis to administer medication, health care, and take blood tests, and in the second model, the patient goes to the hospital on certain days to receive this care and medical visits.
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PMC11317131
Flow rates were increased incrementally each day (black solid line). (
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PMC11764090
tAPX-mediated thylakoid protection serves as a priming hub, which stores information on priming over time .
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PMC8557138
As endothelial cells are one of the primary components of the blood vessels, most of the in vitro model systems of angiogenesis focus on endothelial cell proliferation, migration, and tubule formation assays.
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PMC7841067
The absorbance at 570 nm was determined using a Dynex microplate reader.
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PMC9429973
Indeed, studies of RBC cation content revealed high intracellular Na and low intracellular K, with increased leak flux at 37°C, suggesting a FP.
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PMC10123657
Mass-spectrometry-based shotgun proteomics allows the identification of individual proteins in complex mixtures by measuring the mass-to-charge ratio (m/z) of peptide ions to partially reconstruct their amino acid sequence .
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PMC11597291
The nCGO-PEG(2 kDa) particles exhibited the lowest PCT release at both pH environments (Figure 4).
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PMC9429973
According to the IPSS-R classification included: very high risk (23 pats), high risk (17 pats), intermediate (14 pats), low risk (12 pats), very low risk (2 pats).
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PMC9429973
Complete response (CR)/CR with incomplete hematologic recovery (CRi) rates were higher with A+O (29%/3%) vs O+Clb (13%/1%); 13%/1% had CR/CRi with A; CR increased since the interim analysis (previously 21% [A+O] and 7% [A]).
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PMC6889484
Potential benefits of gene therapy with Vif-resistant A3G-D128K are that CCR5-tropic as well as CXCR4-tropic viruses will be inhibited, and that it is possible to express more than one Vif-resistant A3 protein to inhibit viral replication and spread.
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PMC8526701
Therefore, our findings suggest that BRD9 inhibition-induced PUMA upregulation via the TUFT1/AKT/GSK-3β/p65 signaling pathway.
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PMC10955424
Human A2780cisR cells were plated at 25 × 10 cells/cm in 25 cm cell-culture flasks and incubated in 2.5 mL culture medium (#118,750,939, Thermo Fisher Scientific, MA, USA) for 24 h. 50 % conditioned medium (CM) taken from tumor activated HS-5, was used as positive control for chemoresistance induction.
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PMC11696576
We found that AVX420 was a potent inducer of ROS-dependent cell death and hypothesize that it targets a hitherto unexplored function of cPLA2α in the epigenetic adaptation to ROS.
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PMC10218459
The 20 s CPP treatment led to an almost complete reduction in cell viability.
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PMC11739504
Western blot data showing an increase in Kat2b protein expression during ciliogenesis. (
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PMC8068766
The last two comparisons aimed to answer the question of which gene expressions were altered within a cell line in the presence or absence of Se for HepG2 (Se–HepG2 vs. Se+ HepG2) or HepG2-2.2.15 (Se–HepG2-2.2.15 vs. Se+ HepG2-2.2.15) and called “within cell line” comparisons.
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PMC6364197
With the prolongation of culture time, more cells adhere to the scaffold surface, divide and migrate into the scaffold and get adapted to the new culture environments.
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PMC11743975
The COS-7 cells were transfected either with Tom20-CIBN-GFP (Control group) or with both Tom20-CIBN-GFP and mCherry-CRY2clust (Opto-MitoA group). (
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PMC11549612
786-O control and transfected cells were analyzed for colony formation.
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PMC11545737
OMVs are implicated in cell–cell communication, quorum sensing, stress responses and pathogenesis .
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PMC7185206
Enzyme-linked immunosorbent assay (ELISA) was performed as previously published.
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PMC11237030
Representative bright field images of untransfected (left panel) vs transfected (right panel) CHO-K1 cells at day 0, day 3, day 5, day 7 and day 11 post-transfection with a human AQP5 plasmid.
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PMC10631132
An abundance of ALP-negative cells can be observed following hematopoietic differentiation (empty arrows).
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PMC9429973
MRD was assessed in patients who achieved in stringent complete response (sCR) or CR, and who maintained VGPR over 6 months, with EuroFlow-based next-generation flow (NGF).
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PMC11569208
Secondly, we found that knockdown of both regulatory and catalytic subunits of the phosphoprotein phosphatases family (PP1R16A, PPP4R1, PPP4C, PPP1R10, PPP1R14A, PPP4R1L, and PPP2R2C) conferred VSV∆51 enhancing activity.
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PMC9268620
Most of the cells in treatments with higher doses of 10 and 30 µg/mL were in the later stages of apoptosis.
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PMC11754094
Although most deletions generated by CRISPR nucleases are shorter than 20 base pairs (bp), it was observed that more than 20% of the mutations in mouse embryos induced by CRISPR-Cas9 were unintended deletions longer than 250 bp.
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PMC11391695
The compartments were extracted following a 48-h incubation period, followed by fixation in a 4% solution of paraformaldehyde and staining with a 0.1%ssa solution of crystal violet.
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PMC11754291
This diversity ensures a broader representation of human skin biology and exceeds the standard for comparable studies.
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PMC9429973
Aims: To evaluate tumor and peripheral blood (PB) biomarkers associated with clinical response to glofitamab in the pivotal Phase II expansion.
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PMC8913139
These studies suggest that dysregulation of miRNAs is involved in the pathogenesis of GBM.
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PMC9429973
HR was defined by presence of either del(17p) and/or t(4;14) at diagnosis or study entry.
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PMC11711345
Staurosporine (1 µM in 0.4% DMSO) was applied as a positive control.
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PMC11322866
EZH2 reduction was significantly mitigated by treatment with the proteasome inhibitor MG132 ( Figure 2F).
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PMC7039683
Raw data were aligned to the danRer7 reference genome using Bowtie 2, and peaks were called using MACS2.
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PMC11750161
Gαs and Gαi stimulate and inhibit adenylate cyclase, respectively, thereby regulating cyclic AMP responsiveness.
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PMC9436459
A., Artocarpus; B., Brosimopsis; B.*, Brosimum; C., Chlorophora; D., Dorstenia; M., Morus; S., Sorocea.
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PMC11045125
Cells isolated from primary tumors were initially cultured for 5 days on the irradiated YK6-CD40lg-IL21 feeder layer and then reintroduced as above into NSG mice.
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PMC9250505
E Kaplan–Meier curve: Kaplan–Meier survival curves showed median survival to the humane endpoint and surrogate survival rate in the vehicle (V), NPB (N), Olaparib (O), or a combined NPB-Olaparib-treated group.
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PMC11026382
In the case where a sample did not produce an amplicon, the first round PCR was repeated with 2 µL of the supernatant rather than 1 µL, with the remaining preparation identical.
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PMC11746948
These findings suggest that APT2 depletion leads to increased GPX4 protein levels and aggravates CRC progression.
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PMC9429973
Methods: Pts with previously untreated intermediate, high, or very high–risk MDS per the Revised International Prognostic Scoring System (IPSS-R) received magrolimab IV as a priming dose (1 mg/kg) followed by ramp-up to a 30-mg/kg QW or Q2W maintenance dose.
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PMC9412887
Bera et al. constructed a kind of hypoxia-responsive copolymer (CMP-HA-NI-PEI-NBA) containing nitroaromatic subunits, which could self-assemble into nanomicelles to efficiently deliver erlotinib into cancer cells.
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PMC7642379
The black line indicates the centromere position of each chromosome. (
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PMC11451940
m/z)): 485.27 m/z [Zn(Lap)(phen)] (485.08); 665.35 m/z [Zn(Lap)(phen)2] (665.15).
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PMC3203927
Briefly, the assay samples were re-iteratively reassigned randomly to the classification label (2D, 3D or NS).
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PMC11448304
The bound peptides were eluted from the beads with 0.1% trifluoroacetic acid.
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PMC11476264
After 18 h, transfected cells were combined with 10 μM proteasome inhibitor MG132 for 6 h. The experimental manipulations were continued according to immunoprecipitation and Western blot analysis with indicated with Flag and HA (Proteintech, #81290-1-RR) antibodies.
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PMC11055323
We used PRT4165 (TargetMol T3110) and A485 (MCE HY-107455) to block the H2AK119ub and H3K27ac modification, respectively.
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PMC7685376
Our previous studies demonstrated that Huaier enhanced chemotherapy sensitivity and restrained HCC proliferation.
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PMC10419319
Among these enzymes, HK2-encoding gene is commonly upregulated in cisplatin-resistant cell lines used in experiments.
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PMC9429973
Results: Principal component analysis of the top 100 variable genes revealed 2 major subgroups among patients with PCDs (Fig. 1a).
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PMC8922418
The authors declare that they have no potential conflict of interests.
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PMC10604092
However, IL-1β was elevated in sera of the SLC-transplanted rats (Figure 4C).
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PMC11680578
After pouring off ethanol, a barely visible pellet was found of RNA.
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PMC11487720
5Downregulation of housekeeping proteins and leaking of cytosolic α-tubulin to the enlarging nuclear bubbles during BCD.
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PMC8633974
We posit that clustered regularly interspaced short palindromic repeat (CRISPR) approaches can meet the challenge of viral diversity.
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PMC11767582
H NMR (300 MHz, CDCl3) δ 7.86 (s, 1H), 7.52 (d, J = 8.6 Hz, 1H), 7.15 (d, J = 8.6 Hz, 2H), 6.55 (s, 2H), 3.89 (s, 3H), 3.74 (s, 6H).
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PMC5535901
Data are representative of 3 independent experiments.
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PMC11740207
EnthPCs are characterized by the expression of markers such as CD34, vascular endothelial growth factor receptor 2 (VEGFR2), CD133 antigen, and other markers that are associated with endothelial cells (Aprile et al., 2024).
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PMC11095939
AAV production was performed according to our previous method (Cao et al., 2022).
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