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OTAR3088
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PMC6835428
As this protein is overexpressed in many tumors compared to their normal tissue counterparts, it represents an attractive target for siRNA tumor-specific effects.
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PMC9429973
Evaluation of the DDR following DNA damage, disclosed that BCAT1 deficient cells present an accentuated but defective DDR which translates into marked DNA damage leading to pronounced cell death.
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PMC10988555
Relevant distances are given in Angstrom.
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PMC11757131
Only 60% of the ingested valine is exported in the form of milk, whereas up to 40% is involved in the internal physiological metabolism of the mammary gland (6).
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PMC11144382
These findings suggest that defects in NFIX generally lead to increased CRABP2 expression.
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PMC11758416
Optional: Rinse the wells with 1 mL of fresh complete media to maximize cell count.
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PMC11389534
UFL1 ablation in T cells reduces PD‐1 UFMylation, destabilising PD‐1 and enhancing CD8 T‐cell‐mediated anti‐tumour response.
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PMC10329074
Clone formation ability of A498 cells was investigated through clone formation assay. (
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PMC11755519
These results suggest that overexpression of exosomal BCYRN1 promotes bladder cancer lymphangiogenesis in vitro.
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PMC10135767
The fluorescence intensity of signaling activation has a typical plateau, a rising stage, and then a decreasing phase in firmly adhered cells.
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PMC11767725
In vitro, S. aureus began re-emerging after 14 h, which may reflect the development of phage resistance; however, adding S. epidermidis alongside SaGU1 prevented this bacterial rebound, highlighting a potential synergy between beneficial skin flora and phage therapy.
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PMC9429973
Overall, 51% of pts managed their VOCs at home.
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PMC10887351
D’Agostino et al. proved that β3-AR activation, after electrical field stimulation in human detrusor bladder strips, clearly inhibited contraction and acetylcholine (Ach) release from cholinergic nerves in a concentration-dependent manner .
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PMC11656048
The half maximal inhibitory concentration (IC50) values were calculated using GraphPad Prism 8.0 software (GraphPad Software Inc., San Diego, CA, United States).
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PMC11657744
P < 0.05; **, P < 0.01; ***, P < 0.001. (
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PMC11301095
High levels of IFN-γ in the early stages of infection activate macrophages, enhancing their pathogen phagocytosis and elimination efficacy.
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PMC6684588
Our findings complement those of an earlier study and collectively provide a strong rationale for evaluating follistatin-based interventions such as ACE-083 in disorders with focal muscle weakness.
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PMC9429973
D. A. Pereira-Martins, N. I. Noguera, T. Ottone, A. Diepstra, C. Ortiz, I. Weinhauser, G. Huls, J. J. Schuringa, E. M. Rego, E. Ammatuna Center for Cell Based Therapy, University of Sao Paulo, Ribeirao Preto, Brazil; Department of Experimental Hematology, Cancer Research Centre Groningen, University Medical Center Groningen, Groningen, Netherlands; Department of Biomedicine and Prevention, University of Tor Vergata; Neuro-Oncohematology, Santa Lucia Foundation, I.R.C.C.S., Rome, Italy; Department of Pathology and Medical Biology, Cancer Research Centre Groningen, University Medical Center Groningen, Groningen, Netherlands Background: Although acute promyelocytic leukemia (APL) is the most favorable subtype of acute myeloid leukemia, it remains a life-threating disease for high-risk patients.
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PMC11612508
Resection has drawbacks, including potential harm to brain tissue and cognitive function.
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PMC10810426
In NIH3T3 cells, siRNA knockdown of these 5 nucleoporins had no effect on MLV infection at 24 hpi, as integrated provirus levels were equal to cells treated with the control siRNA (Fig 5A).
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PMC11704135
The MCF-7 cell line, a representative model of human breast cancer cells, was cultured in RPMI-1640 medium supplemented with 10% inactivated fetal calf serum and 50 µg/ml gentamycin.
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PMC9100622
One hypothesis to account for the better rescue effect of GGpp as compared with Fpp is that isopentenyl-pp, an end product of the MVA pathway, is required for the conversion of Fpp to GGpp.
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PMC11659921
Our results revealed significant differences in the expression of immune‐related checkpoint genes between high‐risk and low‐risk groups.
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PMC9429973
G. Paterno, R. Palmieri, V. Forte, F. Bonanni, L. Guarnera, F. Mallegni, M. R. Pascala, B. Elisa, F. Moretti, A. Savi, L. Maurillo, F. Buccisano, A. Venditti, M. I. Del Principe Department of Biomedicine and Prevention, Tor Vergata University, Rome, Italy Background: The International Society of Thrombosis and Haemostasis (ISTH) disseminated intravascular coagulation (DIC) score is widely used to predict mortality in critically ill - typically septic - patients.
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PMC11700247
These outcomes align with studies demonstrating that RT can augment the infiltration and activation of T cells within certain TMEs.
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PMC9429973
Summary/Conclusion: This is the only registrational RCT Phase 3 study in Ph+ ALL, and it compares efficacy and safety of the only third-generation pan-inhibitor BCR::ABL1 TKI PON with first-generation imatinib in combination with chemotherapy in the first-line setting for adult patients with Ph+ ALL.
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PMC11803149
Right graph shows results of tumor volume measurements.
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PMC11025866
EBV infection of B cells caused increased levels of lipid reactive oxygen species that would lead to ferroptosis, an iron-dependent programmed cell death pathway, unless mitigated by cystine transport by xCT .
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PMC11740207
Furthermore, understanding the characteristics of VSELSCs as precursors to CSCs and LSCs could lead to the development of new biomarkers for earlier detection of leukemia and other cancers.
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PMC11640555
Glioblastoma (GBM) is a malignant and aggressive form of cancer among brain tumors, with a low survival rate.
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PMC11248911
for C18H19N3S (309.43): C, 69.87; H, 6.19; N, 13.58; S, 10.36.
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PMC10850553
Secondary antibodies used were as follows; Alexa Fluor 488-conjugated donkey anti-mouse IgG H&L antibody (#A21202, Thermo Fisher Scientific), Alexa Fluor 488-conjugated donkey anti-rabbit IgG H&L antibody (#A21206, Thermo Fisher Scientific), Alexa Fluor 594-conjugated donkey anti-mouse IgG H&L antibody (#A21203, Thermo Fisher Scientific), and Alexa Fluor 594-conjugated donkey anti-rabbit IgG H&L antibody (#A21207, Thermo Fisher Scientific).
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PMC7759933
The cell cycle distribution of the solvent control and treated samples and KI67-positive cells for each day was compared to the first day of the measurements.
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PMC11628309
The search was filtered starting from 1989, the year the BE (2)-M17 cell line was first reported.
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PMC10887351
At the same time, the β3-AR agonists did not increase the urinary retention rate or adverse events rates.
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PMC9672323
The effect of dexamethasone and piroxicam was measured on the cell cycle phase of A-172 cells in non-treated, and treated with 30 μM piroxicam or with 1 μM dexamethasone (n = 3).
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PMC9429973
All the pts had a positive DAT.
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PMC9275501
A summary of the researches of other nanocarriers used to co-deliver chemotherapy drugs and natural active ingredients is shown in Table 9.
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PMC10788478
Upon comparing matched NSCLC tumors and normal tissues, LGR6 expression was found to be significantly higher in lung adenocarcinoma tumors than in paired normal tissues (Figure 2a), whereas there was no significant difference in LGR6 expression levels between squamous cell lung carcinoma tumors and paired normal tissues (Figure 2b).
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PMC5839394
NPs-EPS, diluted to the desiderated concentrations in culture medium, were added to the wells with respective vehicle control (H2O).
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PMC11040965
miR29b has been shown to enhance bortezomib-induced apoptosis in MM plasma cells .
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PMC10538569
RLU detected in mock-, GPI-scFv X5 or AB65-transduced CEMss-CCR5 cells trans-infected with or without HIV-1 pseudotyped AD8, Bru-3, Yu2, CNE3, CNE11, Con B, Con C or JRFL-captured mDCs at 48 hours post co-culture.
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PMC11344246
Epithelial ovarian cancers account for approximately 90–92% of all ovarian malignancies (4), with the most common epithelial histological subtype being high-grade serous ovarian cancer (HGSOC), accounting for approximately 65% of epithelial cases (5); other epithelial histotypes include low-grade serous, endometrioid, clear-cell and mucinous ovarian carcinomas (MOC) (3).
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PMC10873328
Cell adhesion assay was measured according to the manufacturers protocol.
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PMC10728200
Our study highlights that IM could induce ferroptosis in GIST through GPX4, yet GPX4 expression is heterogeneous in patients with GIST.
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PMC11525028
Approximately 35% of patients develop recurrence and metastasis during treatment, leading to an unfavorable prognosis.
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PMC10154097
Gene level was determined using the 2 method.
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PMC11787651
This method allows for fast and reproducible analysis of hundreds of modified histone peptides, capable of analyzing three times more samples per day compared with previous approaches.
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PMC9429973
Summary/Conclusion: Long-term survival of AML is seen in a distinct demographic and biologic patient subset.
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PMC11306331
We benchmarked our results to a gold standard by comparing the extent of MBP-induced dissolution to 1,6-hexanediol-induced dissolution, a chemical that has been frequently used to disperse a variety of condensates.
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PMC11653533
Additionally, its steam is utilized for stomach clutter (Kala, 2005), as well as, the entire plant is used for blood purification (Hussain et al., 2010, Arshad et al., 2011).
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PMC11066331
TUSC3 is involved in co-translational N-glycosylation of proteins with well-known global impact on cell phenotype.
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PMC11301242
Beyond its role in enhancing oncogene expression, as previously mentioned, ecDNA lacks native chromosomal features such as centromeres and telomeres.
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PMC11766332
Most of the evidence has focused on cancer, which has been associated with aberrant glycosylation associated with both genetic and epigenetic modifications of glycogenes .
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PMC10092581
The calibration curve was obtained using known concentrations of standard solutions purchased from Sigma Chemical Co. The assay was performed in 0.2 M Na‐K‐phosphate buffer pH 7.4, containing 5 mM EDTA, 0.250 mM nicotinamide adenine dinucleotide phosphate (NADPH) and 75 nmol of TrxR1 (IMCO, Sweden).
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PMC9429973
After a median FU of 11.7 months (95% CI, 10.5-12.0 months) the 1-yr PFS was 33% for tisa-cel and 47% for axi-cel (HR=1.65, 95% CI 1.26-2.18, P=0.0003).
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PMC11247842
The third strongest association was located on BTA9: 10,451,705 (rs210770707), with an intergenic variant near OGFRL1 as the lead SNP.
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PMC11792090
Levels of IFN-γ, TNF-α, and IL-6 released into the blood of mice. (
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PMC11607764
Furthermore, we revealed the frequent amplification, immune infiltration and significant prognostic value of PTBP1 in pan-cancer, based on a comprehensive analysis of the data.
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PMC11023271
In our study, we show that LPA promoted cell cycle progression of the HaCaT cell line and the SCC cell line, A431, at least partly via down-regulating RIPK4.
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PMC11530949
The assessment of cell cycle and apoptosis is crucial in evaluating the effectiveness of anticancer systems.
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PMC11731161
p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001 Targeting USP7 potentiates the cytotoxic effects of SEL in MM cells in vitro.
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PMC5963610
This behavior is similar to what happens in the clinic with some anti-EGFR mAbs.
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PMC9429973
Furthermore, the probability of NRM was significantly lower in the low-mEASIX group compared to high-mEASIX group (44.8% vs 61.4%; p=0.005; HR: 2.551; 95% CI: 1.318-4.941).
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PMC11787651
Peptides were eluted with two rounds of 80 μl of 80% ACN with centrifugation at 2000g for 1 min.
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PMC9479186
The supernatant was transferred to another centrifugal tube and centrifuged at 11,000g at 4°C for 15 min.
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PMC4112127
DNA from the KMC-1, Mz-ChA-1, and H-69 cell lines was bisulfite treated.
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PMC10777969
Cytotoxicity was analyzed via colorimetric assay.
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PMC7759933
The most important advantages of culturing cells in the form of 3D are increased cell–cell and cell–matrix interactions and higher expression of liver-specific functions (albumin content, urea synthesis, and expression of cytochromes), thus providing a physiologically more relevant model in vivo .
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PMC11240052
no. ab 4051), Anti-Beta actin (1:1000 dilution; cat.
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PMC10092581
On the other hand, mechanistic studies in cancer cells revealed their ability to strongly and selectively inhibit the redox‐regulating enzyme Thioredoxin Reductase (TrxR), being even more effective than auranofin, a well‐known TrxR inhibitor, without affecting other redox enzymes such as Glutathione Reductase (GR).
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PMC11791203
Results are reported as mean values with standard error of the mean (SEM), derived from the observations obtained from four separate experiments, with each experiment conducted in triplicates.
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PMC7612475
Fold change from initiation of treatment was calculated for each tumor per mouse, with mean tumor volumes per group reported.
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PMC11730305
Compared to the normal cells, we observed that Co3O4@Glu-Ellagic acid NPs were more toxic for cancer cells, which can be related to high nutritional requirements and higher metabolic activity of cancer cells.
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PMC10604092
We observed that SLC-transplanted rats had dramatically lower body weights compared with the control rats approximately 15 days after transplantation (Figure 1A; p < 0.01).
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PMC10940855
Multiple myeloma is one of the most common hematologic malignancies (1), and although patient survival has increased over the past two decades as a result of modern therapies, multiple myeloma remains an incurable disease (2).
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PMC11001582
Graph, mean ± s.e.m.,
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PMC11718274
Skin cancer is one of the most prevalent forms of cancer globally, with a significant impact on public health due to its high incidence and associated morbidity.
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PMC11348300
Tissue palpation, a prevalent method for surgeons to assess resection, underscores the well-established concept that compromised neoplastic tissue exhibits poor vascular reactivity.
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PMC11733919
Figure 2e shows the hydrodynamic size distributions of the MNPs after each functionalization step.
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PMC11783017
The antitumor efficacy was studied by assessing tumor growth in terms of the tumor volume, tumor weight, histological staining and so on.
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PMC11224020
Hence, ARP2/3 activity controlled by WASp and Arpin finely tunes the number of DCs that migrate to lymph nodes at steady state, possibly by controlling the cPLA2 activation threshold and downstream CCR7 expression in response to shape sensing.
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PMC8303372
Polymeric nanoparticles (NPs) have attracted interest as delivery vehicles for different compounds, with the potential to overcome issues such as poor drug solubility, cell permeability and unspecific cytotoxicity .
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PMC8143558
It was concluded from the study that the saponin-incorporated vaccine protected the mice models from lethal exposure to rabies .
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PMC11413393
Tumors were allowed to grow to 100–200 mm then randomized into each treatment group of 5 mice per arm.
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PMC11777207
Together, these findings reveal that blocking cis PD-L1:CD80 interactions through PD-L1 antibodies can limit DC migration to the dLN, decrease the amount of IL-17–producing CD4 T cells, and decrease the extent of chronic inflammatory skin disease.
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PMC10565698
Yao Xu: Conceptualization, Investigation, Methodology, Software, Validation, Writing – original draft.
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PMC8609870
Using the TRIzol Reagent (Thermo Fisher Science, USA), we extracted total RNA from the villus tissue samples.
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PMC11785489
While thymic selection imposes a minimum threshold for pMHC reactivity, TCRs that survive this threshold by a wider margin appear more likely to reach a memory T cell state in the periphery.
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PMC10958426
Density plot of the positioning of cells from each tumor subclone on pseudotime trajectories. (
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PMC10745221
Upon histone enrichment in the HCT116 and H460 cells, a histone with SDMA with a molecular weight slightly above 15 kDa was observed (Fig 7 and S5 Fig).
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PMC9429973
The 24 miRNAs signature included underexpressed miRNAs known to act as tumor suppressors regulating cell proliferation or apoptosis (hsa-miR-223-3p, hsa-miR-193a-3p, hsa-miR-181a-5p, hsa-miR-181b-5p, hsa-miR-181c-5p, hsa-miR-708-5p, hsa-miR-34b-5p, and hsa-miR-22-3p).
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PMC11519583
Briefly, 1 μM SPiDER-βGal working solution was added to an MP culture, which was then incubated at 37 °C for 30 min.
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PMC11228511
The meshwork in ~80% of progerin-expressing SMCs appeared indistinguishable from lamin A–expressing cells; however, ~20% of the progerin-expressing cells exhibited an abnormal meshwork with irregularities and large gaps (Fig. 1 B and C).
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PMC8382973
Cytotoxicity of HEC on TZM-bl cells. *
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PMC10253973
Econazole (Ec) release was induced by irradiation with green light and terminated the luminescence.
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PMC11732628
To investigate the role of miR-490-3p in osteosarcoma, miR-490-3p expression in osteosarcoma cells, and hFOB1.19 cells, was initially examined by RT-qPCR.
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PMC5173112
Our data revealed that knockdown of USP21 markedly reduced invasiveness of 786-O (Figure 2E and 2F).
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PMC10213199
Top 20 pathways in KEGG enrichment by Q-Value.
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PMC11560255
They were then blocked with a background sniper and incubated with a 1:50 anti-caspase-9 antibody in a dark room for 1 hour.
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