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PMC11194678
Lower: Statistic data for the sedimentation assay. (
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PMC10222971
Other mechanisms of action have also been described, including the regulation of the tumor suppressor factor p53, inhibition of topoisomerase II, induction of apoptosis via ERS (endoplasmic reticulum stress) or Aurora-kinase inhibitors .
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PMC6889484
Error bars represent SD. (
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PMC10196713
Collectively, these results indicated that Fdx1 may play a pivotal role in suppressing both the upregulated mitochondrial membrane potential and cisplatin-induced lipid peroxidation, thereby conferring cisplatin-resistant properties in OC cells.
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PMC8978939
The following secondary antibodies were used accordingly: anti-rabbit (Cell Signaling, #7074, diluted 1/5,000), anti-goat (Santa Cruz, sc 2020, diluted 1/2,000), and anti-mouse (Cell Signaling, #7076, diluted 1/2,000).
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PMC10849234
The goal of the work herein was to establish a genetically-tractable model of human neutrophil degranulation, in order to enable future studies to investigate molecular players in neutrophil degranulation and to understand the impacts of neutrophil degranulation on other cellular processes.
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PMC10040136
The findings revealed an augmentation in SDF-1 transcriptional expression in GIST cells following contact co-culture (Additional file 1: Fig. S3), which is likely to underlie the promotion of phenotypic transition in MSC and the secretion of TGF-β2.
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PMC11261875
As shown in Fig. 2, it is noteworthy that very few reports have demonstrated the efficacy of drugs targeting the glycolytic system in GIST.Fig.
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PMC11795610
In the intervention group with different concentrations of myricetin, spindle structures disappeared and the cells displayed oval shape, accompanied by tight junction formation between cells.
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PMC9429973
Their epidemiological, clinical, biological and radiological characteristics at admission as well as the therapeutic modality and clinical evolution were collected.
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PMC11726848
The processing and analysis of the results was carried out by the CytExpert 2.3 software (Beckman Coulter, USA).
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PMC9429973
The primary objective was to assess safety of 3 different drug sequencing regimens in cycle 1; the main secondary objective was to assess efficacy.
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PMC11694625
Further, the most potent compound 3c displayed stronger antiproliferative activity against all the selected cancer cell lines than the clinically used anticancer agent 5-FU.
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PMC7840816
Knockdown of SOX9 reversed EMT phenotype in PTC cells.
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PMC11063646
ANG 5, ANG 11 AND optimized emulgel ANG 12 (1 g) were placed on the skin surface (in the donor chamber) and carefully covered to avoid evaporation.
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PMC10852540
Complementary DNA synthesis was performed in order to ensure that the RNAs obtained after the synchronization process could be amplified by polymerase chain reaction (PCR).
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PMC8728081
The zebrafish experiment was done as per The Committee for the Purpose of Control and Supervision of Experiments on Animals (CPCSEA), India.
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PMC9429973
Image: Summary/Conclusion: CB-010, an allogeneic CD19-directed CAR-T cell therapy with a PD-1 KO, demonstrated promising preliminary safety and efficacy in pts with r/r B-NHL at the initial dose level.
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PMC9812014
Molecular docking further revealed that berberine interacts with the E2 protein of HCV—an important protein that facilitates viral entry.
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PMC9672323
The graphs show the mean ± SD.
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PMC10854447
On the other hand, the 2-naphthyl derivative 7n (R = 3,4-C4H4) demonstrated weak antiproliferative activity with a GI50 value of 77 nM, being 2.4-fold and 1.7-fold less potent than Erlotinib and the 1-naphthyl derivative 7m, respectively.
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PMC10998613
However, this earlier work did not characterize the physical properties of the receptor homomers and the CXCR4- β2AR heteromers nor the dependence on the cellular context.
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PMC10529414
In recent years, research on lncRNAs has highlighted their importance in the occurrence and progression of NSCLC.
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PMC10142392
In the work of D. Deokar et al. , it was noted that when PLA was present as the outer block, the sequenced copolymer presented two Tm and Tg, characteristic of each segment, one crystalline and the other amorphous.
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PMC10854447
Caspases are vital for the induction and maintenance of apoptosis.
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PMC11695623
This indicated that the expression level of DCUN1D5 may be associated with immune characteristics.
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PMC11507371
Similarly, the expression of SLC7A11, a cysteine in/glutamate out antiporter, was reduced after CAP treatment, while hydrogen peroxide treatment resulted in increased expression.
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PMC10761571
Finally, apoptosis level in the control and nanoparticle-treated cells was evaluated by a flow cytometry device (BIO-RAD, USA).
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PMC10589262
Quantification of immunofluorescence intensity further demonstrated that MT-KIT evidently colocalized to the Golgi complex (Supplementary Fig. S1).
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PMC10698968
Three-dimensional aggregates started to be visible to the naked eye after 1 week and passaged every 2 weeks.
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PMC11045125
Protein extracts were harvested from tumors infected with ΔEBNA2 EBV alone, or co-infected with ΔEBNA2 EBV and Myc vector, and immunoblot analysis was performed to examine expression of various cellular proteins known to be highly expressed in GC B cells and/or BL tumors as indicated.
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PMC11588008
We designed to use CTX to make a granulocyte chemotherapy damage model in the experimental design phase.
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PMC11587541
In highly inbred regions, the homogeneity of the population might restrict the variation in genetic and environmental factors, affecting the extrapolation of results to more diverse populations.
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PMC9429973
Pharmacological inhibition of glycolysis by targeting 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3(PFKFB3) ameliorates aGvHD.
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PMC6892818
Bcl-2 family proteins Bak/Bax form oligomers to induce MOMP and subsequently apoptosis.
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PMC7553912
The full-length blots are presented in Supplementary Fig. S5.
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PMC11127909
We observed that EFHD1-overexpressing cells exhibited decreased mPTP opening compared with 143B-V cells and significantly decreased mPTP opening after treatment with cisplatin.
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PMC9622879
Let be the input power of the HVAC system in time slot t at home i. This variable can be adjusted continuously within a certain range.1[12pt] $$ 0 p_(t) P_, $$0≤pi(t)≤Pmax,where is the rating power of the HVAC system, and the HVAC energy that is required in time slot t at home i can be calculated as follows:2[12pt] $$ E_(t) = p_(t) t. $$,HVAC(t)=pi(t)·Δt.
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PMC7504302
Second, SFRPs are antagonistic modulators of the Wnt signaling, and their downregulation via hypermethylation could, in part, explain the aberrant activation of the Wnt pathway in MPMs.
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PMC7185206
In the eight samples stained from different patients with melanoma, PD-L1 and ADAM10 or ADAM17 staining were mutually exclusive.
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PMC11015054
At the same time, we have discovered that METTL5 in HCC may be involved in the regulation of tumor immunity, which has not been reported before.
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PMC9429973
Results: A total of 60 consecutive AML patient treated with venetoclax-based combinations were considered in the study.
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PMC9878278
Our previous transcriptomics data showed that ZIKV can trigger an innate immune response through predicted activation of multiple PRR pathways in SC (Strange et al., 2018a) leading to other important questions as to which virus sensing pathways play an active role in controlling ZIKV replication in SC and whether immunosuppressive pathways in SC dampen this effect.
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PMC9429973
Pre-transfusion tests included indirect anti-globulin test (IAT) with gel centrifugation among ABO Rh blood grouping and cross-match.
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PMC11676169
T-ALL cells were seeded on Shi-fix coverslips (Shikhar Biotech, Nepal) according to the manufacturer’s instructions.
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PMC11575040
It is also downregulated in the pulmonary SCC tissues of smoking patients, with statistical analysis indicating an association between LINC00094 dysregulation and poor prognosis .
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PMC9429973
However the GI bleeding significantly reduced the efficacy and survival.
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PMC11615828
In NIH3T3 fibroblasts, kymographs revealed that mNeon‐IFT88 processively moved in anterograde and retrograde directions along CFP‐FRB‐MAP4m‐labeled axonemal MTs.
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PMC11354239
The random nonamers (cat. #
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PMC4360730
The integration of the three ontologies uses three relationships: is_a, part_of and derives_from.
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PMC11611077
However, NLC was not detected in some clones (e.g., EF1α4E10 and CMV 1D5) even though high fluorescent intensities were observed.
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PMC9429973
The mean eculizumab serum trough concentrations and the mean terminal complement activities in both treatment sequences were comparable.
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PMC10998613
In this study, we first employed an agnostic approach to CXCR4 heteromer pair detection with bimolecular fluorescence complementation (BiFC) and found CXCR4-β2AR as a significant interaction pair.
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PMC11767793
A detailed examination of the biological activity mechanism was beyond the scope of this work and could be addressed in subsequent studies.
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PMC10969097
Clinical trial NCT00779168 was a non-randomised clinical trial and for this reason the quality analysis of this study was judged according to the ROBINS-I tool (Figure 3B).
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PMC7612475
This is particularly important for diseases such as MDS, where up to 30% of patients carry the SF3B1 mutation.
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PMC11723947
It finally defines clusters using hierarchical clustering with the average method.
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PMC9848491
It has been shown that cancer is closely related to genes associated with ER stress (15).
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PMC11748335
RNA-seq data revealed that upon ETS1 knockdown, these genes were downregulated (Fig. S7B).
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PMC9429973
Furthermore, the clinical GVHD scores were also lower in the forodesine group vs control (4.9 vs 0.6 points, p = 0.001).
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PMC3730428
Treatment of MPM cell lines with cisplatin resulted in significant (>4-fold) downregulation of FLIP(S) in REN and MM98 cell lines after treatment with 5 μM drug for 48 h, whereas a more modest (∼2-fold) downregulation of FLIP(S) was observed in Ju77 and H28 cells and only after treatment with 10 μM cisplatin (Figure 5a).
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PMC9516447
All graphs were presented as the mean ± Standard Deviation (S.D.).
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PMC9621239
Data on the right of the panel in (A and B) are presented as mean ± standard error of mean (SEM); Unpaired t test; n = 3. (
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PMC11754432
In the skin, arachidonate 5-lipoxygenase (ALOX5) expression is restricted to Langerhans’s and infiltrating immune cells along with some fibroblasts .
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PMC11155445
Hussain et al. synthesized 1,3-disubstituted thiourea (144a–j) derivatives and evaluated them for their carbonic anhydrase inhibiting ability against CA-II, hCA IX, and hCA-XII.
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PMC11543853
The highest cross-correlation was obtained for a pixel size of 1.324 Å. Previously determined PDB structures of the rhinovirus 2 virion (PDB: 1FPN), activated particle (PDB: 4L3B), and empty particle (PDB: 3TN9) were converted to maps.
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PMC9429973
Pancreatitis was identified in 2 subjects (1%) (both Grade 4).
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PMC11638288
Additionally, research has found that a low proportion of NKp46 CD56 CD16 NK cells in non-small cell lung cancer (NSCLC) patients is significantly associated with better OS.
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PMC11532793
For a typical RNA-seq library with 50 million read pairs, the average time for a single bootstrap resample to be drawn was approximately eight times the time for Salmon to draw a single resample using the Gibbs sampling algorithm.
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PMC11772585
HSC-1 or A431 cells were co-transfected with OE-Ctrl, OE METTL1+siCtrl or OE METTL1+siATF4 and pGL3-HK2 promoter.
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PMC11587606
Either two-tailed Student’s t-test or one-way ANOVA was used as needed.
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PMC11335267
Representative spectra from which measurements were carried out.
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PMC11774112
This result was also confirmed by the difference in the mean weight of the tumors isolated on Day 32 (Figure 6B) (P < 0.05).
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PMC11075223
Furthermore, it effectively removed foreign objects from the wound and improved the healing ability (healing rate = 97.75 ± 0.76%) in skin injury mice .
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PMC9429973
Paeoniflorin could effectively improve the behavior of nerve injury in BIPN mice, improve the sciatic nerve damage in mice, and increase the expression of LC3 Ⅱ/I, beclin1 and Parkin proteins related to autophagy in the sciatic nerve of mice. (
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PMC11457557
The fibrotic role of TGF-β1 is mainly due to the Smad-dependent pathway after the phosphorylated SMAD2 and SMAD3 bind to SMAD4 to form a complex.
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PMC11407042
Preheat a water bath to 37°C.b.
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PMC11694346
In contrast, the introduction of biothiols resulted in a pronounced turn-on fluorescence response, highlighting a notably strong and observable orange fluorescence signal.
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PMC6684588
Human FST291 was cloned by PCR using FST315.hFc as template and ligated in the vector pAID4.hFc upstream of, and in-frame with, a sequence encoding human IgG2 Fc.
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PMC11244823
Despite of interesting trends, “true positive” and “true negative” reactors were found among all age groups as well as among mares and geldings.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Despite", "of", "interesting", "trends", ",", "“", "true", "positive", "”", "and", "“", "true", "negative", "”", "reactors", "were", "found", "among", "all", "age", "groups", "as", "well", "as", "among", "mares", "and", "geldings", "." ] } ]
PMC11549612
These investigations are vital for advancing our understanding, ultimately paving the way for enhanced early diagnosis and treatment strategies.
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PMC10719213
In this experiment, 10 nM cladribine in CCRF cells resulted in extensive cell death, and immunoblot was not performed. (
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PMC9429973
For group B: OR and CR rates were 36.7% and 23%, respectively; the side effects rate is 10%.
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PMC11476264
After 16 h, transfected cells were treated with 10 μM MG132 or 20 μM Chloroquine (MedChemExpress, Monmouth Junction, NJ, USA, HY-17589) for 8 h and collected with ice-cold whole-cell extraction buffer (25mM β-Glycerophospholipids PH 7.3, 2 mM EGTA, 10 mM EDTA, 10 mM β-mercaptoethanol, 0.1 M NaCl, 1% Triton X-100, protease inhibitor cocktail) for Western blot analysis.
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PMC11680049
FetMSC cells were cultured in F12/DMEM medium (“PanEco”, Moscow, Russia) supplemented with 10% fetal calf serum (“BioWest”, Nuaillé, France), 50 U/mL penicillin, and 50 mg/mL streptomycin.
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PMC10452486
To determine whether the HLA-B27-Face-2 reached the cell surface in B2m−/− HLA-B27 mice, they stimulated the splenocytes in vitro with Con-A. Low-level expression of HLA-B27-Face-2 was detected on the cell surface of Con A-stimulated splenocytes.
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PMC9429973
Aims: To increase understanding of differences in childbearing patterns among male and female HL survivors treated with ABVD and BEACOPP in a study combining population-based register data from Sweden, Denmark, and Norway.
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PMC8973085
Found: C, 70.27; H, 4.44; N, 8.51.
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PMC9429973
Leukemias of patients with type-1 relapses were often characterized by upregulation of the IL7R pathway, whereas type-2 relapses were characterized by (i) an enrichment of TAL-1 fusion, (ii) and of constitutional mutations in CPG, (iii) divergent genetic and epigenetic remodeling, and (iv) an enrichment of somatic hypermutator phenotypes.
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PMC9429973
Peripheral blood samples were collected to detect KITD816V mutation, using both RT-PCR and ddPCR techniques, and to investigate other molecular mutations using NGS panels for rare and myeloid genes.
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PMC11610461
The results of GSVA and correlation analysis. “*”, “**”
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PMC11047729
O. Cogulu et al. examined the impact of propolis on four childhood leukemia cases—three of which were acute lymphoid leukemia and one was chronic myeloid leukemia.
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PMC10506676
Also, in agreement with our results, a study performed in 2012 on nasopharyngeal carcinoma (NPC) determined that the expression level of the STMN1 gene increased threefold in the presence of EBV-EBNA1 (43).
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PMC11569208
B–E) Human 786-0 cells were seeded in 96-well plates, transfected with RNA from the MISSION silencing RNA (siRNA) Human Phosphatase Library or corresponding controls for 48 h. Cells were then infected with VSV∆51 tagged with firefly luciferase (VSV∆51-fluc) at a multiplicity of infection of 0.05.
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PMC2777936
Antibodies used and dilutions were FZD5, 1:500 (06-756 Upstate, NY), FZD7, 1:250 (AF198 R&D Systems, MN), active-β-catenin (ABC) 1:500 (05-665, Upstate, NY), β-catenin 1:2000 (MD, 610153, BD Transduction Laboratories), JNK and phospho-JNK 1:1000 (9258 and 9251, Cell Signaling Technology, Inc. MA), Oct3/4/POU5F1, 1:750 (H-134, Santa Cruz, CA), α-tubulin 1:1000 (CP06, Calbiochem, CA) and actin 1:2000 (C11, Santa Cruz, CA).
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PMC9436459
A hydrolysis of the MOM-protected S141 delivered a polyphenol, which then gave the acetyl-protected dienophile S142 under the presence of acetic anhydride.
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PMC11626627
The cells were treated with 4 % formaldehyde for 10 min to crosslink the protein-genomic DNA complexes.
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PMC9429973
Aims: To investigate how a lenalidomide-based therapy impact hematopoietic clones in patients with malignant lymphoproliferative disease.
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PMC7612475
Untreated cells were labeled with CldU for 20 minutes, after which, CldU was removed and the cells washed before labeling with IdU for a further 20 minutes.
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PMC11721096
This fishing technique was employed to identify tyrosinase inhibitors from A. sparsifolia and C. arabica.
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